DOI: 10.1016/s1097-2765(03)00053-4. Functional Diversity and Regulation of Different Interleukin-1 Receptor-Associated Kinase (IRAK) Family Members

Functional Diversity and Regulation of Different Interleukin-1 Receptor-Associated Kinase (IRAK) Family Members

10.1016/s1097-2765(03)00053-4

Crossref journal-article

Elsevier BV

Molecular Cell (78)

Bibliography

Janssens, S., & Beyaert, R. (2003). Functional Diversity and Regulation of Different Interleukin-1 Receptor-Associated Kinase (IRAK) Family Members. Molecular Cell, 11(2), 293â302.

Authors 2

Sophie Janssens (first)
Rudi Beyaert (additional)

References 72 Referenced 461

10.1101/gad.13.10.1297 / Genes Dev. / Signaling by pro-inflammatory cytokines by Baud (1999)
10.1016/S0014-5793(00)01759-2 / FEBS Lett. / Translocation of the interleukin-1 receptor-associated kinase-1 (IRAK-1) into the nucleus by Böl (2000)
10.1038/35014038 / Nat. Cell Biol. / Tollip, a new component of the IL-1R pathway, links IRAK to the IL-1 receptor by Burns (2000)
10.1084/jem.20021790 / J. Exp. Med. / Inhibition of IL-1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4 by Burns (2003)
10.1126/science.271.5252.1128 / Science / Irak by Cao (1996)
10.1038/383443a0 / Nature / TRAF6 is a signal transducer for interleukin-1 by Cao (1996)
10.1042/0264-6021:3590403 / Biochem. J. / Functional analysis of the interleukin-1-receptor-associated kinase (IRAK-1) in interleukin-1 beta-stimulated nuclear factor kappa B (NF-κB) pathway activation by Cooke (2001)
10.1074/jbc.270.28.16514 / J. Biol. Chem. / NF-κB activation by interleukin-1 (IL-1) requires an IL-1 receptor-associated protein kinase activity by Croston (1995)
10.1074/jbc.274.12.7724 / J. Biol. Chem. / Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif by Darnay (1999)
10.1016/S0092-8674(00)00126-4 / Cell / Activation of the IκB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain by Deng (2000)
10.1038/35092578 / Nature / Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction by Fitzgerald (2001)
10.1016/S0092-8674(02)00703-1 / Cell Suppl. / Missing pieces in the NF-κB puzzle by Ghosh (2002)
10.1128/MCB.14.6.3559 / Mol. Cell. Biol. / Dorsal, a Drosophila Rel-like protein, is phosphorylated upon activation of the transmembrane protein Toll by Gillespie (1994)
10.1016/S0925-4773(98)00236-6 / Mech. Dev. / Oligomerisation of Tube and Pelle leads to nuclear localisation of dorsal by Grosshans (1999)
10.1038/ni0901-835 / Nat. Immunol. / Tirap by Horng (2001)
10.1038/nature01180 / Nature / The adaptor molecule TIRAP provides signaling specificity for Toll-like receptors by Horng (2002)
10.1016/S0968-0004(02)02145-X / Trends Biochem. Sci. / A universal role for MyD88 in TLR/IL-1R-mediated signaling by Janssens (2002)
10.1016/S0960-9822(02)00712-1 / Curr. Biol. / Regulation of interleukin-1 and lipopolysaccharide-induced NF-κB activation by alternative splicing of MyD88 by Janssens (2002)
10.1074/jbc.M103815200 / J. Biol. Chem. / IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability by Jensen (2001)
10.1128/MCB.22.20.7158-7167.2002 / Mol. Cell. Biol. / Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol by Jiang (2002)
{'key': '10.1016/S1097-2765(03)00053-4_BIB21', 'article-title': 'Pellino 1 is required for IL-1-mediated signaling through its interaction with IRAK4-IRAK-TRAF6', 'volume': 'in press.', 'author': 'Jiang', 'year': '2003', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. / Pellino 1 is required for IL-1-mediated signaling through its interaction with IRAK4-IRAK-TRAF6 by Jiang (2003)
10.1016/S0092-8674(00)81092-2 / Cell / Active and inactive protein kinases by Johnson (1996)
10.1084/jem.187.12.2073 / J. Exp. Med. / Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production by Kanakaraj (1998)
10.1084/jem.189.7.1129 / J. Exp. Med. / Defective interleukin (IL)-18-mediated natural killer and T helper cell type 1 responses in IL-1 receptor-associated kinase (IRAK)-deficient mice by Kanakaraj (1999)
10.1016/S0014-5793(99)00322-1 / FEBS Lett. / Effects of IL-1 receptor-associated kinase (IRAK) expression on IL-1 signaling are independent of its kinase activity by Knop (1999)
10.1002/(SICI)1521-4141(199810)28:10<3100::AID-IMMU3100>3.0.CO;2-7 / Eur. J. Immunol. / Effects of overexpression of IL-1 receptor-associated kinase on NFκB activation, IL-2 production and stress-activated protein kinases in the murine T cell line EL4 by Knop (1998)
10.1093/emboj/20.6.1271 / EMBO J. / Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis by Kobayashi (2001)
10.1016/S0092-8674(02)00827-9 / Cell / IRAK-M is a negative regulator of Toll-like receptor signaling by Kobayashi (2002)
10.1101/gad.13.16.2059 / Genes Dev. / ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway by Kopp (1999)
10.1152/physrev.2001.81.2.807 / Physiol. Rev. / Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation by Kyriakis (2001)
10.1016/S1097-2765(01)00361-6 / Mol. Cell / Targeted disruption of the ζPKC gene results in the impairment of the NF-κB pathway by Leitges (2001)
10.1128/MCB.19.7.4643 / Mol. Cell. Biol. / Mutant cells that do not respond to interleukin-1 (IL-1) reveal a novel role for IL-1 receptor associated kinase by Li (1999)
10.1073/pnas.071054198 / Proc. Natl. Acad. Sci. USA / IL-1-induced NF-κB and c-Jun N-terminal kinase (JNK) activation diverge at IL-1 receptor-associated kinase (IRAK) by Li (2001)
10.1073/pnas.082100399 / Proc. Natl. Acad. Sci. USA / IRAK-4 by Li (2002)
10.1101/gad.13.8.1015 / Genes Dev. / TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling by Lomaga (1999)
10.1074/jbc.M109730200 / J. Biol. Chem. / Identification of interleukin 1 receptor-associated kinase as a conserved component in the p75-neurotrophin receptor activation of nuclear factor-κB by Mamidipudi (2002)
10.1002/1615-4061(200111)1:1/2<37::AID-SITA37>3.0.CO;2-K / Signal Transduction / Interleukin-1 receptor-associated kinase-1 (IRAK-1) by Martin (2001)
10.1002/eji.1830240717 / Eur. J. Immunol. / Interleukin-1-induced activation of a protein kinase co-precipitating with the type I interleukin-1 receptor in T cells by Martin (1994)
10.1042/0264-6021:3390227 / Biochem. J. / Overexpression of an enzymatically inactive interleukin-1-receptor-associated kinase activates NF-κB by Maschera (1999)
10.1038/35100529 / Nat. Rev. Immunol. / Toll-like receptors and innate immunity by Medzhitov (2001)
10.1126/science.278.5343.1612 / Science / IRAK (Pelle) family members IRAK-2 and MyD88 as proximal mediators of IL-1 signaling by Muzio (1997)
10.1038/18465 / Nature / The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway by Ninomiya-Tsuji (1999)
{'key': '10.1016/S1097-2765(03)00053-4_BIB43', 'series-title': 'The interleukin-1 receptor/Toll-like receptor superfamily', 'author': "O'Neill", 'year': '2000'} / The interleukin-1 receptor/Toll-like receptor superfamily by O'Neill (2000)
10.1074/jbc.M102262200 / J. Biol. Chem. / IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFκB by Qian (2001)
10.1159/000056895 / Cytogenet. Cell Genet. / Assignment of homologous genes, Peli1/PELI1 and Peli2/PELI2, for the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14 and human chromosomes 2p13.3 and 14q21, respectively, by physical and radiation mapping by Resch (2001)
10.1007/s002510000249 / Immunogenetics / Pellino-related sequences from Caenorhabditis elegans and Homo sapiens by Rich (2000)
10.1016/S0006-291X(02)00411-4 / Biochem. Biophys. Res. Commun. / Identification and characterization of murine IRAK-M by Rosati (2002)
10.1093/emboj/19.7.1576 / EMBO J. / The atypical PKC-interacting protein p62 channels NF-κB activation by the IL-1-TRAF6 pathway by Sanz (2000)
10.1002/jlb.67.6.767 / J. Leukoc. Biol. / Toll receptors by Schuster (2000)
10.1016/S0952-7915(01)00306-5 / Curr. Opin. Immunol. / IL-1 and IL-18 receptors, and their extended family by Sims (2002)
10.1038/nature736 / Nature / Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4 by Suzuki (2002)
10.4049/jimmunol.164.8.4301 / J. Immunol. / IL-1 receptor-associated kinase modulates host responsiveness to endotoxin by Swantek (2000)
10.1016/S1097-2765(00)80244-0 / Mol. Cell / TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway by Takaesu (2000)
10.1128/MCB.21.7.2475-2484.2001 / Mol. Cell. Biol. / Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway by Takaesu (2001)
10.4049/jimmunol.163.2.978 / J. Immunol. / Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase by Thomas (1999)
10.1074/jbc.271.30.17609 / J. Biol. Chem. / Developmental and tissue-specific expression of mouse pelle-like protein kinase by Trofimova (1996)
10.1074/jbc.274.19.13077 / J. Biol. Chem. / Modulation of tumor necrosis factor and interleukin-1-dependent NF-κB activity by mPLK/IRAK by Vig (1999)
10.1074/jbc.M010399200 / J. Biol. Chem. / SIMPL is a tumor necrosis factor-specific regulator of nuclear factor-κB activity by Vig (2001)
10.1038/35085597 / Nature / TAK1 is a ubiquitin-dependent kinase of MKK and IKK by Wang (2001)
10.1016/S0968-0004(01)01905-3 / Trends Biochem. Sci. / The death domain superfamily by Weber (2001)
10.1016/S1074-7613(00)80402-1 / Immunity / MyD88 by Wesche (1997)
10.1074/jbc.274.27.19403 / J. Biol. Chem. / IRAK-M is a novel member of the pelle/interleukin-1 receptor associated kinase (IRAK) family by Wesche (1999)
10.1126/science.270.5244.2008 / Science / Identification of a member of the MAPKKK family as a potential mediator of TGF-β signal transduction by Yamaguchi (1995)
10.1038/nature01182 / Nature / Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4 by Yamamoto (2002)
10.4049/jimmunol.169.12.6668 / J. Immunol. / Cutting edge by Yamamoto (2002)
10.1074/jbc.272.34.21540 / J. Biol. Chem. / The interleukin-1 receptor-associated kinase is degraded by proteasomes following its phosphorylation by Yamin (1997)
{'key': '10.1016/S1097-2765(03)00053-4_BIB67', 'article-title': 'A novel splice variant of mouse interleukin-1 receptor associated kinase-1 (IRAK-1) activates nuclear factor κB (NF-κB) and c-Jun N-terminal kinase (JNK)', 'volume': 'in press.', 'author': 'Yanagisawa', 'year': '2003', 'journal-title': 'Biochem. J.'} / Biochem. J. / A novel splice variant of mouse interleukin-1 receptor associated kinase-1 (IRAK-1) activates nuclear factor κB (NF-κB) and c-Jun N-terminal kinase (JNK) by Yanagisawa (2003)
10.1038/nature00888 / Nature / Distinct molecular mechanism for initiating TRAF6 signalling by Ye (2002)
10.4049/jimmunol.169.8.4075 / J. Immunol. / Cutting edge by Yu (2002)
10.1073/pnas.130176697 / Proc. Natl. Acad. Sci. USA / MEK kinase 1 gene disruption alters cell migration and c-Jun NH2-terminal kinase regulation but does not cause a measurable defect in NF-κB activation by Yujiri (2000)
10.1074/jbc.275.16.12102 / J. Biol. Chem. / The Drosophila tumor necrosis factor receptor-associated factor-1 (DTRAF1) interacts with Pelle and regulates NF-κB activity by Zapata (2000)
10.1074/jbc.M109537200 / J. Biol. Chem. / Negative regulation of toll-like receptor-mediated signaling by Tollip by Zhang (2002)

Dates

Type	When
Created	21 years, 4 months ago (April 21, 2004, 12:48 a.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, 11:08 p.m.)
Indexed	1 day, 2 hours ago (Aug. 30, 2025, 12:30 p.m.)
Issued	22 years, 6 months ago (Feb. 1, 2003)
Published	22 years, 6 months ago (Feb. 1, 2003)
Published Print	22 years, 6 months ago (Feb. 1, 2003)

Funders 0

None

BibTeX

@article{Janssens_2003, title={Functional Diversity and Regulation of Different Interleukin-1 Receptor-Associated Kinase (IRAK) Family Members}, volume={11}, ISSN={1097-2765}, url={http://dx.doi.org/10.1016/s1097-2765(03)00053-4}, DOI={10.1016/s1097-2765(03)00053-4}, number={2}, journal={Molecular Cell}, publisher={Elsevier BV}, author={Janssens, Sophie and Beyaert, Rudi}, year={2003}, month=feb, pages={293–302} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        30
      ]
    ],
    "date-time": "2025-08-30T16:30:09Z",
    "timestamp": 1756571409395
  },
  "reference-count": 72,
  "publisher": "Elsevier BV",
  "issue": "2",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2003,
            2,
            1
          ]
        ],
        "date-time": "2003-02-01T00:00:00Z",
        "timestamp": 1044057600000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2013,
            7,
            17
          ]
        ],
        "date-time": "2013-07-17T00:00:00Z",
        "timestamp": 1374019200000
      },
      "content-version": "vor",
      "delay-in-days": 3819,
      "URL": "https://www.elsevier.com/open-access/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2003,
        2
      ]
    ]
  },
  "DOI": "10.1016/s1097-2765(03)00053-4",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2004,
        4,
        21
      ]
    ],
    "date-time": "2004-04-21T04:48:34Z",
    "timestamp": 1082522914000
  },
  "page": "293-302",
  "source": "Crossref",
  "is-referenced-by-count": 461,
  "title": "Functional Diversity and Regulation of Different Interleukin-1 Receptor-Associated Kinase (IRAK) Family Members",
  "prefix": "10.1016",
  "volume": "11",
  "author": [
    {
      "given": "Sophie",
      "family": "Janssens",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Rudi",
      "family": "Beyaert",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB1",
      "doi-asserted-by": "crossref",
      "first-page": "1297",
      "DOI": "10.1101/gad.13.10.1297",
      "article-title": "Signaling by pro-inflammatory cytokines",
      "volume": "13",
      "author": "Baud",
      "year": "1999",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "73",
      "DOI": "10.1016/S0014-5793(00)01759-2",
      "article-title": "Translocation of the interleukin-1 receptor-associated kinase-1 (IRAK-1) into the nucleus",
      "volume": "477",
      "author": "B\u00f6l",
      "year": "2000",
      "journal-title": "FEBS Lett."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "346",
      "DOI": "10.1038/35014038",
      "article-title": "Tollip, a new component of the IL-1R pathway, links IRAK to the IL-1 receptor",
      "volume": "2",
      "author": "Burns",
      "year": "2000",
      "journal-title": "Nat. Cell Biol."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB4",
      "doi-asserted-by": "crossref",
      "first-page": "263",
      "DOI": "10.1084/jem.20021790",
      "article-title": "Inhibition of IL-1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4",
      "volume": "197",
      "author": "Burns",
      "year": "2003",
      "journal-title": "J. Exp. Med."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB5",
      "doi-asserted-by": "crossref",
      "first-page": "1128",
      "DOI": "10.1126/science.271.5252.1128",
      "article-title": "Irak",
      "volume": "271",
      "author": "Cao",
      "year": "1996",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "443",
      "DOI": "10.1038/383443a0",
      "article-title": "TRAF6 is a signal transducer for interleukin-1",
      "volume": "383",
      "author": "Cao",
      "year": "1996",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "403",
      "DOI": "10.1042/0264-6021:3590403",
      "article-title": "Functional analysis of the interleukin-1-receptor-associated kinase (IRAK-1) in interleukin-1 beta-stimulated nuclear factor kappa B (NF-\u03baB) pathway activation",
      "volume": "359",
      "author": "Cooke",
      "year": "2001",
      "journal-title": "Biochem. J."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB8",
      "doi-asserted-by": "crossref",
      "first-page": "16514",
      "DOI": "10.1074/jbc.270.28.16514",
      "article-title": "NF-\u03baB activation by interleukin-1 (IL-1) requires an IL-1 receptor-associated protein kinase activity",
      "volume": "270",
      "author": "Croston",
      "year": "1995",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "7724",
      "DOI": "10.1074/jbc.274.12.7724",
      "article-title": "Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif",
      "volume": "274",
      "author": "Darnay",
      "year": "1999",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "351",
      "DOI": "10.1016/S0092-8674(00)00126-4",
      "article-title": "Activation of the I\u03baB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain",
      "volume": "103",
      "author": "Deng",
      "year": "2000",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB11",
      "doi-asserted-by": "crossref",
      "first-page": "78",
      "DOI": "10.1038/35092578",
      "article-title": "Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction",
      "volume": "413",
      "author": "Fitzgerald",
      "year": "2001",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "S81",
      "DOI": "10.1016/S0092-8674(02)00703-1",
      "article-title": "Missing pieces in the NF-\u03baB puzzle",
      "volume": "109",
      "author": "Ghosh",
      "year": "2002",
      "journal-title": "Cell Suppl."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "3559",
      "DOI": "10.1128/MCB.14.6.3559",
      "article-title": "Dorsal, a Drosophila Rel-like protein, is phosphorylated upon activation of the transmembrane protein Toll",
      "volume": "14",
      "author": "Gillespie",
      "year": "1994",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "127",
      "DOI": "10.1016/S0925-4773(98)00236-6",
      "article-title": "Oligomerisation of Tube and Pelle leads to nuclear localisation of dorsal",
      "volume": "81",
      "author": "Grosshans",
      "year": "1999",
      "journal-title": "Mech. Dev."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "835",
      "DOI": "10.1038/ni0901-835",
      "article-title": "Tirap",
      "volume": "2",
      "author": "Horng",
      "year": "2001",
      "journal-title": "Nat. Immunol."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "329",
      "DOI": "10.1038/nature01180",
      "article-title": "The adaptor molecule TIRAP provides signaling specificity for Toll-like receptors",
      "volume": "420",
      "author": "Horng",
      "year": "2002",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "474",
      "DOI": "10.1016/S0968-0004(02)02145-X",
      "article-title": "A universal role for MyD88 in TLR/IL-1R-mediated signaling",
      "volume": "27",
      "author": "Janssens",
      "year": "2002",
      "journal-title": "Trends Biochem. Sci."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "467",
      "DOI": "10.1016/S0960-9822(02)00712-1",
      "article-title": "Regulation of interleukin-1 and lipopolysaccharide-induced NF-\u03baB activation by alternative splicing of MyD88",
      "volume": "12",
      "author": "Janssens",
      "year": "2002",
      "journal-title": "Curr. Biol."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "29037",
      "DOI": "10.1074/jbc.M103815200",
      "article-title": "IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability",
      "volume": "276",
      "author": "Jensen",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "7158",
      "DOI": "10.1128/MCB.22.20.7158-7167.2002",
      "article-title": "Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol",
      "volume": "22",
      "author": "Jiang",
      "year": "2002",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB21",
      "article-title": "Pellino 1 is required for IL-1-mediated signaling through its interaction with IRAK4-IRAK-TRAF6",
      "volume": "in press.",
      "author": "Jiang",
      "year": "2003",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "149",
      "DOI": "10.1016/S0092-8674(00)81092-2",
      "article-title": "Active and inactive protein kinases",
      "volume": "85",
      "author": "Johnson",
      "year": "1996",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "2073",
      "DOI": "10.1084/jem.187.12.2073",
      "article-title": "Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production",
      "volume": "187",
      "author": "Kanakaraj",
      "year": "1998",
      "journal-title": "J. Exp. Med."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "1129",
      "DOI": "10.1084/jem.189.7.1129",
      "article-title": "Defective interleukin (IL)-18-mediated natural killer and T helper cell type 1 responses in IL-1 receptor-associated kinase (IRAK)-deficient mice",
      "volume": "189",
      "author": "Kanakaraj",
      "year": "1999",
      "journal-title": "J. Exp. Med."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "81",
      "DOI": "10.1016/S0014-5793(99)00322-1",
      "article-title": "Effects of IL-1 receptor-associated kinase (IRAK) expression on IL-1 signaling are independent of its kinase activity",
      "volume": "448",
      "author": "Knop",
      "year": "1999",
      "journal-title": "FEBS Lett."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB26",
      "doi-asserted-by": "crossref",
      "first-page": "3100",
      "DOI": "10.1002/(SICI)1521-4141(199810)28:10<3100::AID-IMMU3100>3.0.CO;2-7",
      "article-title": "Effects of overexpression of IL-1 receptor-associated kinase on NF\u03baB activation, IL-2 production and stress-activated protein kinases in the murine T cell line EL4",
      "volume": "28",
      "author": "Knop",
      "year": "1998",
      "journal-title": "Eur. J. Immunol."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB27",
      "doi-asserted-by": "crossref",
      "first-page": "1271",
      "DOI": "10.1093/emboj/20.6.1271",
      "article-title": "Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis",
      "volume": "20",
      "author": "Kobayashi",
      "year": "2001",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "191",
      "DOI": "10.1016/S0092-8674(02)00827-9",
      "article-title": "IRAK-M is a negative regulator of Toll-like receptor signaling",
      "volume": "110",
      "author": "Kobayashi",
      "year": "2002",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "2059",
      "DOI": "10.1101/gad.13.16.2059",
      "article-title": "ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway",
      "volume": "13",
      "author": "Kopp",
      "year": "1999",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "807",
      "DOI": "10.1152/physrev.2001.81.2.807",
      "article-title": "Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation",
      "volume": "81",
      "author": "Kyriakis",
      "year": "2001",
      "journal-title": "Physiol. Rev."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "771",
      "DOI": "10.1016/S1097-2765(01)00361-6",
      "article-title": "Targeted disruption of the \u03b6PKC gene results in the impairment of the NF-\u03baB pathway",
      "volume": "8",
      "author": "Leitges",
      "year": "2001",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "4643",
      "DOI": "10.1128/MCB.19.7.4643",
      "article-title": "Mutant cells that do not respond to interleukin-1 (IL-1) reveal a novel role for IL-1 receptor associated kinase",
      "volume": "19",
      "author": "Li",
      "year": "1999",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "4461",
      "DOI": "10.1073/pnas.071054198",
      "article-title": "IL-1-induced NF-\u03baB and c-Jun N-terminal kinase (JNK) activation diverge at IL-1 receptor-associated kinase (IRAK)",
      "volume": "98",
      "author": "Li",
      "year": "2001",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "5567",
      "DOI": "10.1073/pnas.082100399",
      "article-title": "IRAK-4",
      "volume": "99",
      "author": "Li",
      "year": "2002",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "1015",
      "DOI": "10.1101/gad.13.8.1015",
      "article-title": "TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling",
      "volume": "13",
      "author": "Lomaga",
      "year": "1999",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB36",
      "doi-asserted-by": "crossref",
      "first-page": "28010",
      "DOI": "10.1074/jbc.M109730200",
      "article-title": "Identification of interleukin 1 receptor-associated kinase as a conserved component in the p75-neurotrophin receptor activation of nuclear factor-\u03baB",
      "volume": "277",
      "author": "Mamidipudi",
      "year": "2002",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB37",
      "doi-asserted-by": "crossref",
      "first-page": "37",
      "DOI": "10.1002/1615-4061(200111)1:1/2<37::AID-SITA37>3.0.CO;2-K",
      "article-title": "Interleukin-1 receptor-associated kinase-1 (IRAK-1)",
      "volume": "1\u20132",
      "author": "Martin",
      "year": "2001",
      "journal-title": "Signal Transduction"
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB38",
      "doi-asserted-by": "crossref",
      "first-page": "1566",
      "DOI": "10.1002/eji.1830240717",
      "article-title": "Interleukin-1-induced activation of a protein kinase co-precipitating with the type I interleukin-1 receptor in T cells",
      "volume": "24",
      "author": "Martin",
      "year": "1994",
      "journal-title": "Eur. J. Immunol."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB39",
      "doi-asserted-by": "crossref",
      "first-page": "227",
      "DOI": "10.1042/0264-6021:3390227",
      "article-title": "Overexpression of an enzymatically inactive interleukin-1-receptor-associated kinase activates NF-\u03baB",
      "volume": "339",
      "author": "Maschera",
      "year": "1999",
      "journal-title": "Biochem. J."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "135",
      "DOI": "10.1038/35100529",
      "article-title": "Toll-like receptors and innate immunity",
      "volume": "1",
      "author": "Medzhitov",
      "year": "2001",
      "journal-title": "Nat. Rev. Immunol."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB41",
      "doi-asserted-by": "crossref",
      "first-page": "1612",
      "DOI": "10.1126/science.278.5343.1612",
      "article-title": "IRAK (Pelle) family members IRAK-2 and MyD88 as proximal mediators of IL-1 signaling",
      "volume": "278",
      "author": "Muzio",
      "year": "1997",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB42",
      "doi-asserted-by": "crossref",
      "first-page": "252",
      "DOI": "10.1038/18465",
      "article-title": "The kinase TAK1 can activate the NIK-I\u03baB as well as the MAP kinase cascade in the IL-1 signalling pathway",
      "volume": "398",
      "author": "Ninomiya-Tsuji",
      "year": "1999",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB43",
      "series-title": "The interleukin-1 receptor/Toll-like receptor superfamily",
      "author": "O'Neill",
      "year": "2000"
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB44",
      "doi-asserted-by": "crossref",
      "first-page": "41661",
      "DOI": "10.1074/jbc.M102262200",
      "article-title": "IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NF\u03baB",
      "volume": "276",
      "author": "Qian",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB45",
      "doi-asserted-by": "crossref",
      "first-page": "172",
      "DOI": "10.1159/000056895",
      "article-title": "Assignment of homologous genes, Peli1/PELI1 and Peli2/PELI2, for the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14 and human chromosomes 2p13.3 and 14q21, respectively, by physical and radiation mapping",
      "volume": "92",
      "author": "Resch",
      "year": "2001",
      "journal-title": "Cytogenet. Cell Genet."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB46",
      "doi-asserted-by": "crossref",
      "first-page": "145",
      "DOI": "10.1007/s002510000249",
      "article-title": "Pellino-related sequences from Caenorhabditis elegans and Homo sapiens",
      "volume": "52",
      "author": "Rich",
      "year": "2000",
      "journal-title": "Immunogenetics"
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB47",
      "doi-asserted-by": "crossref",
      "first-page": "1472",
      "DOI": "10.1016/S0006-291X(02)00411-4",
      "article-title": "Identification and characterization of murine IRAK-M",
      "volume": "293",
      "author": "Rosati",
      "year": "2002",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB48",
      "doi-asserted-by": "crossref",
      "first-page": "1576",
      "DOI": "10.1093/emboj/19.7.1576",
      "article-title": "The atypical PKC-interacting protein p62 channels NF-\u03baB activation by the IL-1-TRAF6 pathway",
      "volume": "19",
      "author": "Sanz",
      "year": "2000",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB49",
      "doi-asserted-by": "crossref",
      "first-page": "767",
      "DOI": "10.1002/jlb.67.6.767",
      "article-title": "Toll receptors",
      "volume": "67",
      "author": "Schuster",
      "year": "2000",
      "journal-title": "J. Leukoc. Biol."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB50",
      "doi-asserted-by": "crossref",
      "first-page": "117",
      "DOI": "10.1016/S0952-7915(01)00306-5",
      "article-title": "IL-1 and IL-18 receptors, and their extended family",
      "volume": "14",
      "author": "Sims",
      "year": "2002",
      "journal-title": "Curr. Opin. Immunol."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB51",
      "doi-asserted-by": "crossref",
      "first-page": "750",
      "DOI": "10.1038/nature736",
      "article-title": "Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4",
      "volume": "416",
      "author": "Suzuki",
      "year": "2002",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB52",
      "doi-asserted-by": "crossref",
      "first-page": "4301",
      "DOI": "10.4049/jimmunol.164.8.4301",
      "article-title": "IL-1 receptor-associated kinase modulates host responsiveness to endotoxin",
      "volume": "164",
      "author": "Swantek",
      "year": "2000",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB53",
      "doi-asserted-by": "crossref",
      "first-page": "649",
      "DOI": "10.1016/S1097-2765(00)80244-0",
      "article-title": "TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway",
      "volume": "5",
      "author": "Takaesu",
      "year": "2000",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB54",
      "doi-asserted-by": "crossref",
      "first-page": "2475",
      "DOI": "10.1128/MCB.21.7.2475-2484.2001",
      "article-title": "Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway",
      "volume": "21",
      "author": "Takaesu",
      "year": "2001",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB55",
      "doi-asserted-by": "crossref",
      "first-page": "978",
      "DOI": "10.4049/jimmunol.163.2.978",
      "article-title": "Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase",
      "volume": "163",
      "author": "Thomas",
      "year": "1999",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB56",
      "doi-asserted-by": "crossref",
      "first-page": "17609",
      "DOI": "10.1074/jbc.271.30.17609",
      "article-title": "Developmental and tissue-specific expression of mouse pelle-like protein kinase",
      "volume": "271",
      "author": "Trofimova",
      "year": "1996",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB57",
      "doi-asserted-by": "crossref",
      "first-page": "13077",
      "DOI": "10.1074/jbc.274.19.13077",
      "article-title": "Modulation of tumor necrosis factor and interleukin-1-dependent NF-\u03baB activity by mPLK/IRAK",
      "volume": "274",
      "author": "Vig",
      "year": "1999",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB58",
      "doi-asserted-by": "crossref",
      "first-page": "7859",
      "DOI": "10.1074/jbc.M010399200",
      "article-title": "SIMPL is a tumor necrosis factor-specific regulator of nuclear factor-\u03baB activity",
      "volume": "276",
      "author": "Vig",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB59",
      "doi-asserted-by": "crossref",
      "first-page": "346",
      "DOI": "10.1038/35085597",
      "article-title": "TAK1 is a ubiquitin-dependent kinase of MKK and IKK",
      "volume": "412",
      "author": "Wang",
      "year": "2001",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB60",
      "doi-asserted-by": "crossref",
      "first-page": "475",
      "DOI": "10.1016/S0968-0004(01)01905-3",
      "article-title": "The death domain superfamily",
      "volume": "26",
      "author": "Weber",
      "year": "2001",
      "journal-title": "Trends Biochem. Sci."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB61",
      "doi-asserted-by": "crossref",
      "first-page": "837",
      "DOI": "10.1016/S1074-7613(00)80402-1",
      "article-title": "MyD88",
      "volume": "7",
      "author": "Wesche",
      "year": "1997",
      "journal-title": "Immunity"
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB62",
      "doi-asserted-by": "crossref",
      "first-page": "19403",
      "DOI": "10.1074/jbc.274.27.19403",
      "article-title": "IRAK-M is a novel member of the pelle/interleukin-1 receptor associated kinase (IRAK) family",
      "volume": "274",
      "author": "Wesche",
      "year": "1999",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB63",
      "doi-asserted-by": "crossref",
      "first-page": "2008",
      "DOI": "10.1126/science.270.5244.2008",
      "article-title": "Identification of a member of the MAPKKK family as a potential mediator of TGF-\u03b2 signal transduction",
      "volume": "270",
      "author": "Yamaguchi",
      "year": "1995",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB64",
      "doi-asserted-by": "crossref",
      "first-page": "324",
      "DOI": "10.1038/nature01182",
      "article-title": "Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4",
      "volume": "420",
      "author": "Yamamoto",
      "year": "2002",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB65",
      "doi-asserted-by": "crossref",
      "first-page": "6668",
      "DOI": "10.4049/jimmunol.169.12.6668",
      "article-title": "Cutting edge",
      "volume": "169",
      "author": "Yamamoto",
      "year": "2002",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB66",
      "doi-asserted-by": "crossref",
      "first-page": "21540",
      "DOI": "10.1074/jbc.272.34.21540",
      "article-title": "The interleukin-1 receptor-associated kinase is degraded by proteasomes following its phosphorylation",
      "volume": "272",
      "author": "Yamin",
      "year": "1997",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB67",
      "article-title": "A novel splice variant of mouse interleukin-1 receptor associated kinase-1 (IRAK-1) activates nuclear factor \u03baB (NF-\u03baB) and c-Jun N-terminal kinase (JNK)",
      "volume": "in press.",
      "author": "Yanagisawa",
      "year": "2003",
      "journal-title": "Biochem. J."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB68",
      "doi-asserted-by": "crossref",
      "first-page": "443",
      "DOI": "10.1038/nature00888",
      "article-title": "Distinct molecular mechanism for initiating TRAF6 signalling",
      "volume": "418",
      "author": "Ye",
      "year": "2002",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB69",
      "doi-asserted-by": "crossref",
      "first-page": "4075",
      "DOI": "10.4049/jimmunol.169.8.4075",
      "article-title": "Cutting edge",
      "volume": "169",
      "author": "Yu",
      "year": "2002",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB70",
      "doi-asserted-by": "crossref",
      "first-page": "7272",
      "DOI": "10.1073/pnas.130176697",
      "article-title": "MEK kinase 1 gene disruption alters cell migration and c-Jun NH2-terminal kinase regulation but does not cause a measurable defect in NF-\u03baB activation",
      "volume": "97",
      "author": "Yujiri",
      "year": "2000",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB71",
      "doi-asserted-by": "crossref",
      "first-page": "12102",
      "DOI": "10.1074/jbc.275.16.12102",
      "article-title": "The Drosophila tumor necrosis factor receptor-associated factor-1 (DTRAF1) interacts with Pelle and regulates NF-\u03baB activity",
      "volume": "275",
      "author": "Zapata",
      "year": "2000",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1097-2765(03)00053-4_BIB72",
      "doi-asserted-by": "crossref",
      "first-page": "7059",
      "DOI": "10.1074/jbc.M109537200",
      "article-title": "Negative regulation of toll-like receptor-mediated signaling by Tollip",
      "volume": "277",
      "author": "Zhang",
      "year": "2002",
      "journal-title": "J. Biol. Chem."
    }
  ],
  "container-title": "Molecular Cell",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S1097276503000534?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S1097276503000534?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2024,
        1,
        13
      ]
    ],
    "date-time": "2024-01-13T04:08:00Z",
    "timestamp": 1705118880000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S1097276503000534"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2003,
        2
      ]
    ]
  },
  "references-count": 72,
  "journal-issue": {
    "issue": "2",
    "published-print": {
      "date-parts": [
        [
          2003,
          2
        ]
      ]
    }
  },
  "alternative-id": [
    "S1097276503000534"
  ],
  "URL": "http://dx.doi.org/10.1016/S1097-2765(03)00053-4",
  "relation": {},
  "ISSN": [
    "1097-2765"
  ],
  "subject": [],
  "container-title-short": "Molecular Cell",
  "published": {
    "date-parts": [
      [
        2003,
        2
      ]
    ]
  }
}