DOI: 10.1016/s1097-2765(02)00519-1. The PHD Domain of MEKK1 Acts as an E3 Ubiquitin Ligase and Mediates Ubiquitination and Degradation of ERK1/2

The PHD Domain of MEKK1 Acts as an E3 Ubiquitin Ligase and Mediates Ubiquitination and Degradation of ERK1/2

10.1016/s1097-2765(02)00519-1

Crossref journal-article

Elsevier BV

Molecular Cell (78)

Bibliography

Lu, Z., Xu, S., Joazeiro, C., Cobb, M. H., & Hunter, T. (2002). The PHD Domain of MEKK1 Acts as an E3 Ubiquitin Ligase and Mediates Ubiquitination and Degradation of ERK1/2. Molecular Cell, 9(5), 945â956.

Authors 5

Zhimin Lu (first)
Shuichan Xu (additional)
Claudio Joazeiro (additional)
Melanie H Cobb (additional)
Tony Hunter (additional)

References 59 Referenced 266

10.1006/geno.2000.6168 / Genomics / Isolation and initial characterization of a novel zinc finger gene, DNMT3L, on 21q22.3, related to the cytosine-5-methyltransferase 3 gene family by Aapola (2000)
10.1016/S0968-0004(00)88957-4 / Trends Biochem. Sci. / The PHD finger by Aasland (1995)
10.1016/S0960-9822(00)00398-5 / Curr. Biol. / The U box is a modified RING finger—a common domain in ubiquitination by Aravind (2000)
10.1016/S0959-440X(96)80060-1 / Curr. Opin. Struct. Biol. / The RING finger domain by Borden (1996)
10.1126/science.280.5367.1262 / Science / Catalytic activation of the phosphatase MKP-3 by ERK2 mitogen-activated protein kinase by Camps (1998)
10.1016/S0092-8674(00)80351-7 / Cell / Activation mechanism of the MAP kinase ERK2 by dual phosphorylation by Canagarajah (1997)
10.1093/emboj/20.1.165 / EMBO J. / Solution structure of the PHD domain from the KAP-1 corepressor by Capili (2001)
10.1038/35065000 / Nature / Mammalian MAP kinase signalling cascades by Chang (2001)
10.1016/S0079-6107(98)00056-X / Prog. Biophys. Mol. Biol. / MAP kinase pathways by Cobb (1999)
10.1083/jcb.200111010 / J. Cell Biol. / A novel class of herpesvirus-encoded membrane-bound E3 ubiquitin ligases regulates endocytosis of proteins involved in immune recognition by Coscoy (2001)
10.1006/excr.2000.4836 / Exp. Cell Res. / Serine/threonine protein kinases and apoptosis by Cross (2000)
10.1016/S0092-8674(00)00116-1 / Cell / Signal transduction by the JNK group of MAP kinases by Davis (2000)
10.1042/bj3220185 / Biochem. J. / Regulation of the activity of MEK kinase 1 (MEKK1) by autophosphorylation within the kinase activation domain by Deak (1997)
{'key': '10.1016/S1097-2765(02)00519-1_BIB14', 'first-page': 'L670', 'article-title': 'Osmotic stress induces both secretion and apoptosis in rat alveolar type II cells', 'volume': '275', 'author': 'Edwards', 'year': '1998', 'journal-title': 'Am. J. Physiol.'} / Am. J. Physiol. / Osmotic stress induces both secretion and apoptosis in rat alveolar type II cells by Edwards (1998)
10.1128/MCB.19.8.5308 / Mol. Cell. Biol. / B-Raf inhibits programmed cell death downstream of cytochrome c release from mitochondria by activating the MEK/Erk pathway by Erhardt (1999)
10.1111/j.1749-6632.1993.tb32280.x / Ann. N Y Acad. Sci. / The RING finger. A novel protein sequence motif related to the zinc finger by Freemont (1993)
{'key': '10.1016/S1097-2765(02)00519-1_BIB17', 'first-page': '2649', 'article-title': 'The epidermal growth factor receptor is covalently linked to ubiquitin', 'volume': '11', 'author': 'Galcheva-Gargova', 'year': '1995', 'journal-title': 'Oncogene'} / Oncogene / The epidermal growth factor receptor is covalently linked to ubiquitin by Galcheva-Gargova (1995)
10.1038/ng1097-146 / Nat. Genet. / Mutations in transcriptional regulator ATRX establish the functional significance of a PHD-like domain by Gibbons (1997)
{'key': '10.1016/S1097-2765(02)00519-1_BIB19', 'first-page': '3143', 'article-title': 'Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas', 'volume': '60', 'author': 'Gunduz', 'year': '2000', 'journal-title': 'Cancer Res.'} / Cancer Res. / Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas by Gunduz (2000)
10.1016/S0960-9822(99)80453-9 / Curr. Biol. / Ubiquitin-dependent degradation of active Src by Hakak (1999)
10.1073/pnas.96.24.13738 / Proc. Natl. Acad. Sci. USA / Ubiquitin-mediated degradation of active Src tyrosine kinase by Harris (1999)
10.1074/jbc.M102755200 / J. Biol. Chem. / U box proteins as a new family of ubiquitin-protein ligases by Hatakeyama (2001)
10.55782/ane-2000-1374 / Acta Neurobiol. Exp. / Signaling pathways mediating anti-apoptotic action of neurotrophins by Hetman (2000)
10.1146/annurev.genet.30.1.405 / Annu. Rev. Genet. / Ubiquitin-dependent protein degradation by Hochstrasser (1996)
10.1093/emboj/19.20.5418 / EMBO J. / MAPK/ERK signaling in activated T cells inhibits CD95/Fas-mediated apoptosis downstream of DISC assembly by Holmstrom (2000)
10.1006/prep.1999.1180 / Protein Expr. Purif. / Membrane-bound human 3beta-hydroxysteroid dehydrogenase by Huang (2000)
10.1016/S0962-8924(00)01834-1 / Trends Cell Biol. / The lore of the RINGs by Jackson (2000)
10.1016/S0959-437X(99)80027-6 / Curr. Opin. Genet. Dev. / Modifying chromatin and concepts of cancer by Jacobson (1999)
10.1126/science.289.5487.2061 / Science / Biochemistry. Ubiquitination–more than two to tango by Joazeiro (2000)
10.1126/science.286.5438.309 / Science / The tyrosine kinase negative regulator c-Cbl as a RING-type, E2- dependent ubiquitin-protein ligase by Joazeiro (1999)
10.1074/jbc.270.29.17442 / J. Biol. Chem. / A proteolytic pathway that recognizes ubiquitin as a degradation signal by Johnson (1995)
10.1074/jbc.M005926200 / J. Biol. Chem. / MEKK1 binds raf-1 and the ERK2 cascade components by Karandikar (2000)
10.1074/jbc.272.17.11057 / J. Biol. Chem. / Reconstitution of mitogen-activated protein kinase phosphorylation cascades in bacteria. Efficient synthesis of active protein kinases by Khokhlatchev (1997)
10.1016/S0092-8674(00)80574-7 / Cell / A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly by Koegl (1999)
10.1016/S1286-4579(00)00366-X / Microbes Infect. / Characterization of apoptosis induced by sorbitol by Koyama (2000)
10.1126/science.8385802 / Science / A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf by Lange-Carter (1993)
10.1091/mbc.11.7.2315 / Mol. Biol. Cell / The APC11 RING-H2 finger mediates E2-dependent ubiquitination by Leverson (2000)
10.1006/jmbi.2000.3766 / J. Mol. Biol. / Biochemical analyses of the AF10 protein by Linder (2000)
10.1006/geno.1998.5578 / Genomics / A novel human gene, WSTF, is deleted in Williams syndrome by Lu (1998)
10.1128/MCB.18.2.839 / Mol. Cell. Biol. / Activation of protein kinase C triggers its ubiquitination and degradation by Lu (1998)
10.1074/jbc.C000684200 / J. Biol. Chem. / MEK inhibition enhances paclitaxel-induced tumor apoptosis by MacKeigan (2000)
10.1126/science.7992057 / Science / Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK by Minden (1994)
10.1016/S0021-9258(18)54190-9 / J. Biol. Chem. / Ligand-induced ubiquitination of the platelet-derived growth factor beta-receptor plays a negative regulatory role in its mitogenic signaling by Mori (1993)
10.1006/jmbi.2000.4308 / J. Mol. Biol. / Structure of the PHD zinc finger from human Williams-Beuren syndrome transcription factor by Pascual (2000)
10.1093/hmg/8.2.277 / Hum. Mol. Genet. / AIRE encodes a nuclear protein co-localizing with cytoskeletal filaments by Rinderle (1999)
10.1073/pnas.92.21.9737 / Proc. Natl. Acad. Sci. USA / The leukemia-associated-protein (LAP) domain, a cysteine-rich motif, is present in a wide range of proteins, including MLL, AF10, and MLLT6 proteins by Saha (1995)
10.1530/eje.0.1440347 / Eur J Endocrinol / Identification of a novel mutation in the autoimmune regulator (AIRE-1) gene in a French family with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy by Saugier-Veber (2001)
10.1073/pnas.95.13.7439 / Proc. Natl. Acad. Sci. USA / Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/akt by Scheid (1998)
{'key': '10.1016/S1097-2765(02)00519-1_BIB49', 'first-page': '1533', 'article-title': 'Inhibition of extracellular signal-regulated kinase (ERK) mediates cell cycle phase independent apoptosis in vinblastine-treated ML-1 cells', 'volume': '61', 'author': 'Stadheim', 'year': '2001', 'journal-title': 'Cancer Res.'} / Cancer Res. / Inhibition of extracellular signal-regulated kinase (ERK) mediates cell cycle phase independent apoptosis in vinblastine-treated ML-1 cells by Stadheim (2001)
10.1038/35000065 / Nat. Cell Biol. / A conserved docking motif in MAP kinases common to substrates, activators and regulators by Tanoue (2000)
10.1074/jbc.M010384200 / J. Biol. Chem. / MAPK/ERK overrides the apoptotic signaling from Fas, TNF, and TRAIL receptors by Tran (2001)
10.1073/pnas.97.10.5243 / Proc. Natl. Acad. Sci. USA / MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration by Xia (2000)
10.1126/science.270.5240.1326 / Science / Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis by Xia (1995)
10.1073/pnas.92.15.6808 / Proc. Natl. Acad. Sci. USA / MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase by Xu (1995)
10.1073/pnas.93.11.5291 / Proc. Natl. Acad. Sci. USA / Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane- associated 195-kDa protein with a large regulatory domain by Xu (1996)
10.1074/jbc.275.12.8817 / J. Biol. Chem. / The Ras/phosphatidylinositol 3-kinase and Ras/ERK pathways function as independent survival modules each of which inhibits a distinct apoptotic signaling pathway in sympathetic neurons by Xue (2000)
10.1038/372798a0 / Nature / Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1 by Yan (1994)
10.1016/S0021-9258(18)31793-9 / J. Biol. Chem. / Mechanism of down-regulation of c-kit receptor. Roles of receptor tyrosine kinase, phosphatidylinositol 3′-kinase, and protein kinase C by Yee (1994)
10.1126/science.282.5395.1911 / Science / Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption by Yujiri (1998)

Dates

Type	When
Created	21 years, 4 months ago (April 21, 2004, 2:04 a.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, 11:14 p.m.)
Indexed	1 day, 19 hours ago (Sept. 4, 2025, 10:25 a.m.)
Issued	23 years, 4 months ago (May 1, 2002)
Published	23 years, 4 months ago (May 1, 2002)
Published Print	23 years, 4 months ago (May 1, 2002)

Funders 3

U.S. Public Health Service 10.13039/100007197
Region: Americas
gov (National government)
Labels6
1. United States Public Health Service
2. Commissioned Corps of the U.S. Public Health Service
3. USPHS Commissioned Corps
4. U.S. Public Health Service Commissioned Corps
5. USPHS
6. PHS
Awards4
1. CA14195
2. GM 56498
3. CA82863
4. 6FB-0108
California Breast Cancer Research Program 10.13039/100004802
Region: Americas
gov (Local government)
Labels2
1. The California Breast Cancer Research Program
2. CBCRP
Awards4
1. CA14195
2. GM 56498
3. CA82863
4. 6FB-0108
National Institutes of Health 10.13039/100000002
Region: Americas
gov (National government)
Labels3
1. Institutos Nacionales de la Salud
2. US National Institutes of Health
3. NIH
Awards4
1. CA14195
2. GM 56498
3. CA82863
4. 6FB-0108

BibTeX

@article{Lu_2002, title={The PHD Domain of MEKK1 Acts as an E3 Ubiquitin Ligase and Mediates Ubiquitination and Degradation of ERK1/2}, volume={9}, ISSN={1097-2765}, url={http://dx.doi.org/10.1016/s1097-2765(02)00519-1}, DOI={10.1016/s1097-2765(02)00519-1}, number={5}, journal={Molecular Cell}, publisher={Elsevier BV}, author={Lu, Zhimin and Xu, Shuichan and Joazeiro, Claudio and Cobb, Melanie H and Hunter, Tony}, year={2002}, month=may, pages={945–956} }

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      "year": "2000",
      "journal-title": "Cancer Res."
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    {
      "key": "10.1016/S1097-2765(02)00519-1_BIB20",
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      "first-page": "1039",
      "DOI": "10.1016/S0960-9822(99)80453-9",
      "article-title": "Ubiquitin-dependent degradation of active Src",
      "volume": "9",
      "author": "Hakak",
      "year": "1999",
      "journal-title": "Curr. Biol."
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    {
      "key": "10.1016/S1097-2765(02)00519-1_BIB21",
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      "first-page": "13738",
      "DOI": "10.1073/pnas.96.24.13738",
      "article-title": "Ubiquitin-mediated degradation of active Src tyrosine kinase",
      "volume": "96",
      "author": "Harris",
      "year": "1999",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S1097-2765(02)00519-1_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "33111",
      "DOI": "10.1074/jbc.M102755200",
      "article-title": "U box proteins as a new family of ubiquitin-protein ligases",
      "volume": "276",
      "author": "Hatakeyama",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1097-2765(02)00519-1_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "531",
      "DOI": "10.55782/ane-2000-1374",
      "article-title": "Signaling pathways mediating anti-apoptotic action of neurotrophins",
      "volume": "60",
      "author": "Hetman",
      "year": "2000",
      "journal-title": "Acta Neurobiol. Exp."
    },
    {
      "key": "10.1016/S1097-2765(02)00519-1_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "405",
      "DOI": "10.1146/annurev.genet.30.1.405",
      "article-title": "Ubiquitin-dependent protein degradation",
      "volume": "30",
      "author": "Hochstrasser",
      "year": "1996",
      "journal-title": "Annu. Rev. Genet."
    },
    {
      "key": "10.1016/S1097-2765(02)00519-1_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "5418",
      "DOI": "10.1093/emboj/19.20.5418",
      "article-title": "MAPK/ERK signaling in activated T cells inhibits CD95/Fas-mediated apoptosis downstream of DISC assembly",
      "volume": "19",
      "author": "Holmstrom",
      "year": "2000",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/S1097-2765(02)00519-1_BIB26",
      "doi-asserted-by": "crossref",
      "first-page": "169",
      "DOI": "10.1006/prep.1999.1180",
      "article-title": "Membrane-bound human 3beta-hydroxysteroid dehydrogenase",
      "volume": "18",
      "author": "Huang",
      "year": "2000",
      "journal-title": "Protein Expr. Purif."
    },
    {
      "key": "10.1016/S1097-2765(02)00519-1_BIB27",
      "doi-asserted-by": "crossref",
      "first-page": "429",
      "DOI": "10.1016/S0962-8924(00)01834-1",
      "article-title": "The lore of the RINGs",
      "volume": "10",
      "author": "Jackson",
      "year": "2000",
      "journal-title": "Trends Cell Biol."
    },
    {
      "key": "10.1016/S1097-2765(02)00519-1_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "175",
      "DOI": "10.1016/S0959-437X(99)80027-6",
      "article-title": "Modifying chromatin and concepts of cancer",
      "volume": "9",
      "author": "Jacobson",
      "year": "1999",
      "journal-title": "Curr. Opin. Genet. Dev."
    },
    {
      "key": "10.1016/S1097-2765(02)00519-1_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "2061",
      "DOI": "10.1126/science.289.5487.2061",
      "article-title": "Biochemistry. Ubiquitination\u2013more than two to tango",
      "volume": "289",
      "author": "Joazeiro",
      "year": "2000",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S1097-2765(02)00519-1_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "309",
      "DOI": "10.1126/science.286.5438.309",
      "article-title": "The tyrosine kinase negative regulator c-Cbl as a RING-type, E2- dependent ubiquitin-protein ligase",
      "volume": "286",
      "author": "Joazeiro",
      "year": "1999",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S1097-2765(02)00519-1_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "17442",
      "DOI": "10.1074/jbc.270.29.17442",
      "article-title": "A proteolytic pathway that recognizes ubiquitin as a degradation signal",
      "volume": "270",
      "author": "Johnson",
      "year": "1995",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1097-2765(02)00519-1_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "40120",
      "DOI": "10.1074/jbc.M005926200",
      "article-title": "MEKK1 binds raf-1 and the ERK2 cascade components",
      "volume": "275",
      "author": "Karandikar",
      "year": "2000",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1097-2765(02)00519-1_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "11057",
      "DOI": "10.1074/jbc.272.17.11057",
      "article-title": "Reconstitution of mitogen-activated protein kinase phosphorylation cascades in bacteria. Efficient synthesis of active protein kinases",
      "volume": "272",
      "author": "Khokhlatchev",
      "year": "1997",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1097-2765(02)00519-1_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "635",
      "DOI": "10.1016/S0092-8674(00)80574-7",
      "article-title": "A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly",
      "volume": "96",
      "author": "Koegl",
      "year": "1999",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S1097-2765(02)00519-1_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "599",
      "DOI": "10.1016/S1286-4579(00)00366-X",
      "article-title": "Characterization of apoptosis induced by sorbitol",
      "volume": "2",
      "author": "Koyama",
      "year": "2000",
      "journal-title": "Microbes Infect."
    },
    {
      "key": "10.1016/S1097-2765(02)00519-1_BIB36",
      "doi-asserted-by": "crossref",
      "first-page": "315",
      "DOI": "10.1126/science.8385802",
      "article-title": "A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf",
      "volume": "260",
      "author": "Lange-Carter",
      "year": "1993",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S1097-2765(02)00519-1_BIB37",
      "doi-asserted-by": "crossref",
      "first-page": "2315",
      "DOI": "10.1091/mbc.11.7.2315",
      "article-title": "The APC11 RING-H2 finger mediates E2-dependent ubiquitination",
      "volume": "11",
      "author": "Leverson",
      "year": "2000",
      "journal-title": "Mol. Biol. Cell"
    },
    {
      "key": "10.1016/S1097-2765(02)00519-1_BIB38",
      "doi-asserted-by": "crossref",
      "first-page": "369",
      "DOI": "10.1006/jmbi.2000.3766",
      "article-title": "Biochemical analyses of the AF10 protein",
      "volume": "299",
      "author": "Linder",
      "year": "2000",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/S1097-2765(02)00519-1_BIB39",
      "doi-asserted-by": "crossref",
      "first-page": "241",
      "DOI": "10.1006/geno.1998.5578",
      "article-title": "A novel human gene, WSTF, is deleted in Williams syndrome",
      "volume": "54",
      "author": "Lu",
      "year": "1998",
      "journal-title": "Genomics"
    },
    {
      "key": "10.1016/S1097-2765(02)00519-1_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "839",
      "DOI": "10.1128/MCB.18.2.839",
      "article-title": "Activation of protein kinase C triggers its ubiquitination and degradation",
      "volume": "18",
      "author": "Lu",
      "year": "1998",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/S1097-2765(02)00519-1_BIB41",
      "doi-asserted-by": "crossref",
      "first-page": "38953",
      "DOI": "10.1074/jbc.C000684200",
      "article-title": "MEK inhibition enhances paclitaxel-induced tumor apoptosis",
      "volume": "275",
      "author": "MacKeigan",
      "year": "2000",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1097-2765(02)00519-1_BIB42",
      "doi-asserted-by": "crossref",
      "first-page": "1719",
      "DOI": "10.1126/science.7992057",
      "article-title": "Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK",
      "volume": "266",
      "author": "Minden",
      "year": "1994",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S1097-2765(02)00519-1_BIB43",
      "doi-asserted-by": "crossref",
      "first-page": "577",
      "DOI": "10.1016/S0021-9258(18)54190-9",
      "article-title": "Ligand-induced ubiquitination of the platelet-derived growth factor beta-receptor plays a negative regulatory role in its mitogenic signaling",
      "volume": "268",
      "author": "Mori",
      "year": "1993",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1097-2765(02)00519-1_BIB44",
      "doi-asserted-by": "crossref",
      "first-page": "723",
      "DOI": "10.1006/jmbi.2000.4308",
      "article-title": "Structure of the PHD zinc finger from human Williams-Beuren syndrome transcription factor",
      "volume": "304",
      "author": "Pascual",
      "year": "2000",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/S1097-2765(02)00519-1_BIB45",
      "doi-asserted-by": "crossref",
      "first-page": "277",
      "DOI": "10.1093/hmg/8.2.277",
      "article-title": "AIRE encodes a nuclear protein co-localizing with cytoskeletal filaments",
      "volume": "8",
      "author": "Rinderle",
      "year": "1999",
      "journal-title": "Hum. Mol. Genet."
    },
    {
      "key": "10.1016/S1097-2765(02)00519-1_BIB46",
      "doi-asserted-by": "crossref",
      "first-page": "9737",
      "DOI": "10.1073/pnas.92.21.9737",
      "article-title": "The leukemia-associated-protein (LAP) domain, a cysteine-rich motif, is present in a wide range of proteins, including MLL, AF10, and MLLT6 proteins",
      "volume": "92",
      "author": "Saha",
      "year": "1995",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S1097-2765(02)00519-1_BIB47",
      "doi-asserted-by": "crossref",
      "first-page": "347",
      "DOI": "10.1530/eje.0.1440347",
      "article-title": "Identification of a novel mutation in the autoimmune regulator (AIRE-1) gene in a French family with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy",
      "volume": "144",
      "author": "Saugier-Veber",
      "year": "2001",
      "journal-title": "Eur J Endocrinol"
    },
    {
      "key": "10.1016/S1097-2765(02)00519-1_BIB48",
      "doi-asserted-by": "crossref",
      "first-page": "7439",
      "DOI": "10.1073/pnas.95.13.7439",
      "article-title": "Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/akt",
      "volume": "95",
      "author": "Scheid",
      "year": "1998",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S1097-2765(02)00519-1_BIB49",
      "first-page": "1533",
      "article-title": "Inhibition of extracellular signal-regulated kinase (ERK) mediates cell cycle phase independent apoptosis in vinblastine-treated ML-1 cells",
      "volume": "61",
      "author": "Stadheim",
      "year": "2001",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/S1097-2765(02)00519-1_BIB50",
      "doi-asserted-by": "crossref",
      "first-page": "110",
      "DOI": "10.1038/35000065",
      "article-title": "A conserved docking motif in MAP kinases common to substrates, activators and regulators",
      "volume": "2",
      "author": "Tanoue",
      "year": "2000",
      "journal-title": "Nat. Cell Biol."
    },
    {
      "key": "10.1016/S1097-2765(02)00519-1_BIB51",
      "doi-asserted-by": "crossref",
      "first-page": "16484",
      "DOI": "10.1074/jbc.M010384200",
      "article-title": "MAPK/ERK overrides the apoptotic signaling from Fas, TNF, and TRAIL receptors",
      "volume": "276",
      "author": "Tran",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1097-2765(02)00519-1_BIB52",
      "doi-asserted-by": "crossref",
      "first-page": "5243",
      "DOI": "10.1073/pnas.97.10.5243",
      "article-title": "MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration",
      "volume": "97",
      "author": "Xia",
      "year": "2000",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S1097-2765(02)00519-1_BIB53",
      "doi-asserted-by": "crossref",
      "first-page": "1326",
      "DOI": "10.1126/science.270.5240.1326",
      "article-title": "Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis",
      "volume": "270",
      "author": "Xia",
      "year": "1995",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S1097-2765(02)00519-1_BIB54",
      "doi-asserted-by": "crossref",
      "first-page": "6808",
      "DOI": "10.1073/pnas.92.15.6808",
      "article-title": "MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase",
      "volume": "92",
      "author": "Xu",
      "year": "1995",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S1097-2765(02)00519-1_BIB55",
      "doi-asserted-by": "crossref",
      "first-page": "5291",
      "DOI": "10.1073/pnas.93.11.5291",
      "article-title": "Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane- associated 195-kDa protein with a large regulatory domain",
      "volume": "93",
      "author": "Xu",
      "year": "1996",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S1097-2765(02)00519-1_BIB56",
      "doi-asserted-by": "crossref",
      "first-page": "8817",
      "DOI": "10.1074/jbc.275.12.8817",
      "article-title": "The Ras/phosphatidylinositol 3-kinase and Ras/ERK pathways function as independent survival modules each of which inhibits a distinct apoptotic signaling pathway in sympathetic neurons",
      "volume": "275",
      "author": "Xue",
      "year": "2000",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1097-2765(02)00519-1_BIB57",
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      "first-page": "798",
      "DOI": "10.1038/372798a0",
      "article-title": "Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1",
      "volume": "372",
      "author": "Yan",
      "year": "1994",
      "journal-title": "Nature"
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    {
      "key": "10.1016/S1097-2765(02)00519-1_BIB58",
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      "DOI": "10.1016/S0021-9258(18)31793-9",
      "article-title": "Mechanism of down-regulation of c-kit receptor. Roles of receptor tyrosine kinase, phosphatidylinositol 3\u2032-kinase, and protein kinase C",
      "volume": "269",
      "author": "Yee",
      "year": "1994",
      "journal-title": "J. Biol. Chem."
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    {
      "key": "10.1016/S1097-2765(02)00519-1_BIB59",
      "doi-asserted-by": "crossref",
      "first-page": "1911",
      "DOI": "10.1126/science.282.5395.1911",
      "article-title": "Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption",
      "volume": "282",
      "author": "Yujiri",
      "year": "1998",
      "journal-title": "Science"
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