DOI: 10.1016/s1097-2765(00)80063-5. Selective Inhibition of NFAT Activation by a Peptide Spanning the Calcineurin Targeting Site of NFAT

Selective Inhibition of NFAT Activation by a Peptide Spanning the Calcineurin Targeting Site of NFAT

10.1016/s1097-2765(00)80063-5

Crossref journal-article

Elsevier BV

Molecular Cell (78)

Bibliography

Aramburu, J., GarcÃa-CÃ³zar, F., Raghavan, A., Okamura, H., Rao, A., & Hogan, P. G. (1998). Selective Inhibition of NFAT Activation by a Peptide Spanning the Calcineurin Targeting Site of NFAT. Molecular Cell, 1(5), 627â637.

Authors 6

José Aramburu (first)
Francisco García-Cózar (additional)
Anuradha Raghavan (additional)
Heidi Okamura (additional)
Anjana Rao (additional)
Patrick G Hogan (additional)

References 55 Referenced 253

10.1111/j.1432-1033.1992.tb17508.x / Eur. J. Biochem / The control of protein phosphatase-1 by targeting subunits by Alessi (1992)
10.1084/jem.182.3.801 / J. Exp. Med / Activation and expression of the nuclear factors of activated T cells, NFATp and NFATc, in human natural killer cells by Aramburu (1995)
10.1101/gad.11.7.824 / Genes Dev / Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction by Beals (1997)
10.1016/0952-7915(93)90135-F / Curr. Opin. Immunol / Cyclosporin A and FK506 by Bierer (1993)
10.1016/S0021-9258(19)83888-7 / J. Biol. Chem / Dephosphorylation of cAMP-dependent protein kinase regulatory subunit (type II) by calmodulin-dependent protein phosphatase. Determinants of substrate specificity by Blumenthal (1986)
10.1074/jbc.272.44.27582 / J. Biol. Chem / FKBP12 binds the inositol 1,4,5-triphosphate receptor at leucine-proline (1400–1401) and anchors calcineurin to this FK506-like domain by Cameron (1997)
10.1016/0092-8674(95)90124-8 / Cell / Calcineurin associated with the inositol 1,4,5-triphosphate receptor–FKBP12 complex modulates Ca2+ flux by Cameron (1995)
10.1016/1074-7613(94)90096-5 / Immunity / Induction of NF-AT in normal B lymphocytes by anti-immunoglobulin or CD40 ligand in conjunction with IL-4 by Choi (1994)
10.1126/science.7528941 / Science / Association of protein kinase A and protein phosphatase 2B with a common anchoring protein by Coghlan (1995)
10.1146/annurev.bi.63.070194.005145 / Annu. Rev. Biochem / Signal transmission between the plasma membrane and nucleus of T-lymphocytes by Crabtree (1994)
10.1016/0014-5793(95)01184-G / FEBS Lett / Amino acid sequence and expression of the hepatic glycogen-binding GL-subunit of PP1 by Doherty (1995)
10.1016/0014-5793(93)80850-T / FEBS Lett / Dephosphorylation of tau protein and Alzheimer paired helical filaments by calcineurin and phosphatase-2A by Drewes (1993)
10.1093/emboj/16.8.1876 / EMBO J / Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1 by Egloff (1997)
10.1021/bi952940f / Biochemistry / Multiple structural elements define the specificity of recombinant human inhibitor-1 as a protein phosphatase-1 inhibitor by Endo (1996)
10.1074/jbc.272.27.17038 / J. Biol. Chem / Regulation of the AKAP79-protein kinase C interaction by Ca2+/calmodulin by Faux (1997)
10.1016/0092-8674(95)90439-5 / Cell / X-ray structure of calcineurin inhibited by the immunophilin–immunosuppressant FKBP12–FK506 complex by Griffith (1995)
10.1016/S0021-9258(19)39919-3 / J. Biol. Chem / Identification of an autoinhibitory domain in calcineurin by Hashimoto (1990)
10.4049/jimmunol.159.11.5431 / J. Immunol / δ-opioid receptors expressed by Jurkat T cells enhance IL-2 secretion by increasing AP-1 complexes and activity of the NFAT/AP-1-binding promoter element by Hedin (1997)
10.1006/abio.1996.9952 / Anal. Biochem / Recombinant strategies for rapid purification of catalytic subunits of cAMP-dependent protein kinase by Hemmer (1997)
10.1016/1074-7613(95)90027-6 / Immunity / Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins by Hoey (1995)
10.1016/0968-0004(93)90109-Z / Trends Biochem. Sci / On target with a new mechanism for the regulation of protein phosphorylation by Hubbard (1993)
10.1074/jbc.270.27.16333 / J. Biol. Chem / FcεRI-mediated induction of nuclear factor of activated T-cells by Hutchinson (1995)
10.1038/378641a0 / Nature / Crystal structures of human calcineurin and the human FKBP12–FK506–calcineurin complex by Kissinger (1995)
10.1126/science.271.5255.1589 / Science / Coordination of three signaling enzymes by AKAP79, a mammalian scaffold protein by Klauck (1996)
10.1073/pnas.94.8.3536 / Proc. Natl. Acad. Sci. USA / Characterization of the interaction between DARPP-32 and protein phosphatase 1 (PP-1) by Kwon (1997)
10.1016/0896-6273(89)90050-0 / Neuron / The microtubule binding domain of tau protein by Lee (1989)
10.1016/0167-5699(93)90048-P / Immunol. Today / FK506 and cyclosporin, molecular probes for studying intracellular signal transduction by Liu (1993)
10.1016/0092-8674(91)90124-H / Cell / Calcineurin is a common target of cyclophilin–cyclosporin A and FKBP–FK506 complexes by Liu (1991)
10.1128/MCB.16.7.3945 / Mol. Cell. Biol / T-cell receptor stimulation elicits an early phase of activation and a later phase of deactivation of the transcription factor NFAT1 by Loh (1996)
10.1074/jbc.271.18.10884 / J. Biol. Chem / Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity by Loh (1996)
10.1128/MCB.16.7.3955 / Mol. Cell. Biol / Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes by Luo (1996)
10.1084/jem.184.1.141 / J. Exp. Med / Mechanisms of transactivation by nuclear factor of activated T cells-1 by Luo (1996)
10.1073/pnas.93.17.8907 / Proc. Natl. Acad. Sci. USA / Interaction of calcineurin with a domain of the transcription factor NFAT1 that controls nuclear import by Luo (1996)
10.1128/MCB.17.5.2475 / Mol. Cell. Biol / Expression of NFAT-family proteins in normal human T cells by Lyakh (1997)
10.1128/MCB.15.5.2697 / Mol. Cell. Biol / NFATx, a novel member of the NFAT family that is expressed predominantly in the thymus by Masuda (1995)
10.1128/MCB.17.4.2066 / Mol. Cell. Biol / Control of NFATx1 nuclear translocation by a calcineurin-regulated inhibitory domain by Masuda (1997)
10.1002/j.1460-2075.1990.tb07893.x / EMBO J / The actions of cyclosporin A and FK506 suggest a novel step in the activation of T lymphocytes by Mattila (1990)
10.1126/science.8235597 / Science / Isolation of the cyclosporin-sensitive T cell transcription factor NFATp by McCaffrey (1993)
10.1038/369497a0 / Nature / NF-AT components define a family of transcription factors targeted in T-cell activation by Northrop (1994)
10.1016/0167-5699(94)90007-8 / Immunol. Today / NF-ATp by Rao (1994)
10.1146/annurev.immunol.15.1.707 / Annu. Rev. Immunol / Transcription factors of the NFAT family by Rao (1997)
10.1016/0167-5699(92)90111-J / Immunol. Today / The mechanism of action of cyclosporin A and FK506 by Schreiber (1992)
10.1073/pnas.92.24.11205 / Proc. Natl. Acad. Sci. USA / Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells by Shaw (1995)
10.1038/382370a0 / Nature / Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4 by Shibasaki (1996)
10.1128/MCB.14.8.5076 / Mol. Cell. Biol / One exon of the human LSF gene includes conserved regions involved in novel DNA-binding and dimerization by Shirra (1994)
10.1084/jem.173.3.619 / J. Exp. Med / Is cyclophilin involved in the immunosuppressive and nephrotoxic mechanism of action of cyclosporin A? by Sigal (1991)
10.1038/372231a0 / Nature / Signal transduction and regulation in smooth muscle by Somlyo (1994)
10.1016/S0021-9258(18)98477-2 / J. Biol. Chem / Molecular cloning and expression of the regulatory (RGL) subunit of glycogen-associated protein phosphatase by Tang (1991)
10.1074/jbc.270.6.2451 / J. Biol. Chem / Characterization of an exchange reaction between soluble FKBP-12 and the FKBP·ryanodine receptor complex by Timerman (1995)
10.1038/383837a0 / Nature / Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression by Timmerman (1996)
10.4049/jimmunol.145.12.4355 / J. Immunol / Transformation of T lymphocytes by the v-fos oncogene by Valge-Archer (1990)
10.1016/1074-7613(94)90097-3 / Immunity / Cyclosporin-A sensitive induction of NF-AT in murine B cells by Venkataraman (1994)
10.1111/j.1749-6632.1995.tb26661.x / Ann. NY Acad. Sci / The cyclosporin-sensitive transcription factor NFATp is expressed in several classes of cells in the immune system by Wang (1995)
10.1016/S0092-8674(00)80116-6 / Cell / The immunophilin FKBP12 functions as a common inhibitor of the TGFβ family type I receptors by Wang (1996)
10.1074/jbc.271.3.1274 / J. Biol. Chem / Identification of a physical interaction between calcineurin and nuclear factor of activated T cells (NFATp) by Wesselborg (1996)

Dates

Type	When
Created	21 years, 2 months ago (June 11, 2004, 8:29 a.m.)
Deposited	1 year, 7 months ago (Jan. 13, 2024, 11:44 a.m.)
Indexed	2 months ago (June 27, 2025, 9:45 a.m.)
Issued	27 years, 4 months ago (April 1, 1998)
Published	27 years, 4 months ago (April 1, 1998)
Published Print	27 years, 4 months ago (April 1, 1998)

Funders 0

None

BibTeX

@article{Aramburu_1998, title={Selective Inhibition of NFAT Activation by a Peptide Spanning the Calcineurin Targeting Site of NFAT}, volume={1}, ISSN={1097-2765}, url={http://dx.doi.org/10.1016/s1097-2765(00)80063-5}, DOI={10.1016/s1097-2765(00)80063-5}, number={5}, journal={Molecular Cell}, publisher={Elsevier BV}, author={Aramburu, José and García-Cózar, Francisco and Raghavan, Anuradha and Okamura, Heidi and Rao, Anjana and Hogan, Patrick G}, year={1998}, month=apr, pages={627–637} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        6,
        27
      ]
    ],
    "date-time": "2025-06-27T13:45:13Z",
    "timestamp": 1751031913423
  },
  "reference-count": 55,
  "publisher": "Elsevier BV",
  "issue": "5",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1998,
            4,
            1
          ]
        ],
        "date-time": "1998-04-01T00:00:00Z",
        "timestamp": 891388800000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2013,
            7,
            17
          ]
        ],
        "date-time": "2013-07-17T00:00:00Z",
        "timestamp": 1374019200000
      },
      "content-version": "vor",
      "delay-in-days": 5586,
      "URL": "https://www.elsevier.com/open-access/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1998,
        4
      ]
    ]
  },
  "DOI": "10.1016/s1097-2765(00)80063-5",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2004,
        6,
        11
      ]
    ],
    "date-time": "2004-06-11T12:29:10Z",
    "timestamp": 1086956950000
  },
  "page": "627-637",
  "source": "Crossref",
  "is-referenced-by-count": 253,
  "title": "Selective Inhibition of NFAT Activation by a Peptide Spanning the Calcineurin Targeting Site of NFAT",
  "prefix": "10.1016",
  "volume": "1",
  "author": [
    {
      "given": "Jos\u00e9",
      "family": "Aramburu",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Francisco",
      "family": "Garc\u00eda-C\u00f3zar",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Anuradha",
      "family": "Raghavan",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Heidi",
      "family": "Okamura",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Anjana",
      "family": "Rao",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Patrick G",
      "family": "Hogan",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB1",
      "doi-asserted-by": "crossref",
      "first-page": "1023",
      "DOI": "10.1111/j.1432-1033.1992.tb17508.x",
      "article-title": "The control of protein phosphatase-1 by targeting subunits",
      "volume": "210",
      "author": "Alessi",
      "year": "1992",
      "journal-title": "Eur. J. Biochem"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "801",
      "DOI": "10.1084/jem.182.3.801",
      "article-title": "Activation and expression of the nuclear factors of activated T cells, NFATp and NFATc, in human natural killer cells",
      "volume": "182",
      "author": "Aramburu",
      "year": "1995",
      "journal-title": "J. Exp. Med"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "824",
      "DOI": "10.1101/gad.11.7.824",
      "article-title": "Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction",
      "volume": "11",
      "author": "Beals",
      "year": "1997",
      "journal-title": "Genes Dev"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB4",
      "doi-asserted-by": "crossref",
      "first-page": "763",
      "DOI": "10.1016/0952-7915(93)90135-F",
      "article-title": "Cyclosporin A and FK506",
      "volume": "5",
      "author": "Bierer",
      "year": "1993",
      "journal-title": "Curr. Opin. Immunol"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB5",
      "doi-asserted-by": "crossref",
      "first-page": "8140",
      "DOI": "10.1016/S0021-9258(19)83888-7",
      "article-title": "Dephosphorylation of cAMP-dependent protein kinase regulatory subunit (type II) by calmodulin-dependent protein phosphatase. Determinants of substrate specificity",
      "volume": "261",
      "author": "Blumenthal",
      "year": "1986",
      "journal-title": "J. Biol. Chem"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "27582",
      "DOI": "10.1074/jbc.272.44.27582",
      "article-title": "FKBP12 binds the inositol 1,4,5-triphosphate receptor at leucine-proline (1400\u20131401) and anchors calcineurin to this FK506-like domain",
      "volume": "272",
      "author": "Cameron",
      "year": "1997",
      "journal-title": "J. Biol. Chem"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "463",
      "DOI": "10.1016/0092-8674(95)90124-8",
      "article-title": "Calcineurin associated with the inositol 1,4,5-triphosphate receptor\u2013FKBP12 complex modulates Ca2+ flux",
      "volume": "83",
      "author": "Cameron",
      "year": "1995",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB8",
      "doi-asserted-by": "crossref",
      "first-page": "179",
      "DOI": "10.1016/1074-7613(94)90096-5",
      "article-title": "Induction of NF-AT in normal B lymphocytes by anti-immunoglobulin or CD40 ligand in conjunction with IL-4",
      "volume": "1",
      "author": "Choi",
      "year": "1994",
      "journal-title": "Immunity"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "108",
      "DOI": "10.1126/science.7528941",
      "article-title": "Association of protein kinase A and protein phosphatase 2B with a common anchoring protein",
      "volume": "267",
      "author": "Coghlan",
      "year": "1995",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "1045",
      "DOI": "10.1146/annurev.bi.63.070194.005145",
      "article-title": "Signal transmission between the plasma membrane and nucleus of T-lymphocytes",
      "volume": "63",
      "author": "Crabtree",
      "year": "1994",
      "journal-title": "Annu. Rev. Biochem"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB11",
      "doi-asserted-by": "crossref",
      "first-page": "294",
      "DOI": "10.1016/0014-5793(95)01184-G",
      "article-title": "Amino acid sequence and expression of the hepatic glycogen-binding GL-subunit of PP1",
      "volume": "375",
      "author": "Doherty",
      "year": "1995",
      "journal-title": "FEBS Lett"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "425",
      "DOI": "10.1016/0014-5793(93)80850-T",
      "article-title": "Dephosphorylation of tau protein and Alzheimer paired helical filaments by calcineurin and phosphatase-2A",
      "volume": "336",
      "author": "Drewes",
      "year": "1993",
      "journal-title": "FEBS Lett"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "1876",
      "DOI": "10.1093/emboj/16.8.1876",
      "article-title": "Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1",
      "volume": "16",
      "author": "Egloff",
      "year": "1997",
      "journal-title": "EMBO J"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "5220",
      "DOI": "10.1021/bi952940f",
      "article-title": "Multiple structural elements define the specificity of recombinant human inhibitor-1 as a protein phosphatase-1 inhibitor",
      "volume": "35",
      "author": "Endo",
      "year": "1996",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "17038",
      "DOI": "10.1074/jbc.272.27.17038",
      "article-title": "Regulation of the AKAP79-protein kinase C interaction by Ca2+/calmodulin",
      "volume": "272",
      "author": "Faux",
      "year": "1997",
      "journal-title": "J. Biol. Chem"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "507",
      "DOI": "10.1016/0092-8674(95)90439-5",
      "article-title": "X-ray structure of calcineurin inhibited by the immunophilin\u2013immunosuppressant FKBP12\u2013FK506 complex",
      "volume": "82",
      "author": "Griffith",
      "year": "1995",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "1924",
      "DOI": "10.1016/S0021-9258(19)39919-3",
      "article-title": "Identification of an autoinhibitory domain in calcineurin",
      "volume": "265",
      "author": "Hashimoto",
      "year": "1990",
      "journal-title": "J. Biol. Chem"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "5431",
      "DOI": "10.4049/jimmunol.159.11.5431",
      "article-title": "\u03b4-opioid receptors expressed by Jurkat T cells enhance IL-2 secretion by increasing AP-1 complexes and activity of the NFAT/AP-1-binding promoter element",
      "volume": "159",
      "author": "Hedin",
      "year": "1997",
      "journal-title": "J. Immunol"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "115",
      "DOI": "10.1006/abio.1996.9952",
      "article-title": "Recombinant strategies for rapid purification of catalytic subunits of cAMP-dependent protein kinase",
      "volume": "245",
      "author": "Hemmer",
      "year": "1997",
      "journal-title": "Anal. Biochem"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "461",
      "DOI": "10.1016/1074-7613(95)90027-6",
      "article-title": "Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins",
      "volume": "2",
      "author": "Hoey",
      "year": "1995",
      "journal-title": "Immunity"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB21",
      "doi-asserted-by": "crossref",
      "first-page": "172",
      "DOI": "10.1016/0968-0004(93)90109-Z",
      "article-title": "On target with a new mechanism for the regulation of protein phosphorylation",
      "volume": "18",
      "author": "Hubbard",
      "year": "1993",
      "journal-title": "Trends Biochem. Sci"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "16333",
      "DOI": "10.1074/jbc.270.27.16333",
      "article-title": "Fc\u03b5RI-mediated induction of nuclear factor of activated T-cells",
      "volume": "270",
      "author": "Hutchinson",
      "year": "1995",
      "journal-title": "J. Biol. Chem"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "641",
      "DOI": "10.1038/378641a0",
      "article-title": "Crystal structures of human calcineurin and the human FKBP12\u2013FK506\u2013calcineurin complex",
      "volume": "378",
      "author": "Kissinger",
      "year": "1995",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "1589",
      "DOI": "10.1126/science.271.5255.1589",
      "article-title": "Coordination of three signaling enzymes by AKAP79, a mammalian scaffold protein",
      "volume": "271",
      "author": "Klauck",
      "year": "1996",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "3536",
      "DOI": "10.1073/pnas.94.8.3536",
      "article-title": "Characterization of the interaction between DARPP-32 and protein phosphatase 1 (PP-1)",
      "volume": "94",
      "author": "Kwon",
      "year": "1997",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB26",
      "doi-asserted-by": "crossref",
      "first-page": "1615",
      "DOI": "10.1016/0896-6273(89)90050-0",
      "article-title": "The microtubule binding domain of tau protein",
      "volume": "2",
      "author": "Lee",
      "year": "1989",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB27",
      "doi-asserted-by": "crossref",
      "first-page": "290",
      "DOI": "10.1016/0167-5699(93)90048-P",
      "article-title": "FK506 and cyclosporin, molecular probes for studying intracellular signal transduction",
      "volume": "14",
      "author": "Liu",
      "year": "1993",
      "journal-title": "Immunol. Today"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "807",
      "DOI": "10.1016/0092-8674(91)90124-H",
      "article-title": "Calcineurin is a common target of cyclophilin\u2013cyclosporin A and FKBP\u2013FK506 complexes",
      "volume": "66",
      "author": "Liu",
      "year": "1991",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "3945",
      "DOI": "10.1128/MCB.16.7.3945",
      "article-title": "T-cell receptor stimulation elicits an early phase of activation and a later phase of deactivation of the transcription factor NFAT1",
      "volume": "16",
      "author": "Loh",
      "year": "1996",
      "journal-title": "Mol. Cell. Biol"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "10884",
      "DOI": "10.1074/jbc.271.18.10884",
      "article-title": "Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity",
      "volume": "271",
      "author": "Loh",
      "year": "1996",
      "journal-title": "J. Biol. Chem"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "3955",
      "DOI": "10.1128/MCB.16.7.3955",
      "article-title": "Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes",
      "volume": "16",
      "author": "Luo",
      "year": "1996",
      "journal-title": "Mol. Cell. Biol"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "141",
      "DOI": "10.1084/jem.184.1.141",
      "article-title": "Mechanisms of transactivation by nuclear factor of activated T cells-1",
      "volume": "184",
      "author": "Luo",
      "year": "1996",
      "journal-title": "J. Exp. Med"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "8907",
      "DOI": "10.1073/pnas.93.17.8907",
      "article-title": "Interaction of calcineurin with a domain of the transcription factor NFAT1 that controls nuclear import",
      "volume": "93",
      "author": "Luo",
      "year": "1996",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "2475",
      "DOI": "10.1128/MCB.17.5.2475",
      "article-title": "Expression of NFAT-family proteins in normal human T cells",
      "volume": "17",
      "author": "Lyakh",
      "year": "1997",
      "journal-title": "Mol. Cell. Biol"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "2697",
      "DOI": "10.1128/MCB.15.5.2697",
      "article-title": "NFATx, a novel member of the NFAT family that is expressed predominantly in the thymus",
      "volume": "15",
      "author": "Masuda",
      "year": "1995",
      "journal-title": "Mol. Cell. Biol"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB36",
      "doi-asserted-by": "crossref",
      "first-page": "2066",
      "DOI": "10.1128/MCB.17.4.2066",
      "article-title": "Control of NFATx1 nuclear translocation by a calcineurin-regulated inhibitory domain",
      "volume": "17",
      "author": "Masuda",
      "year": "1997",
      "journal-title": "Mol. Cell. Biol"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB37",
      "doi-asserted-by": "crossref",
      "first-page": "4425",
      "DOI": "10.1002/j.1460-2075.1990.tb07893.x",
      "article-title": "The actions of cyclosporin A and FK506 suggest a novel step in the activation of T lymphocytes",
      "volume": "9",
      "author": "Mattila",
      "year": "1990",
      "journal-title": "EMBO J"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB38",
      "doi-asserted-by": "crossref",
      "first-page": "750",
      "DOI": "10.1126/science.8235597",
      "article-title": "Isolation of the cyclosporin-sensitive T cell transcription factor NFATp",
      "volume": "262",
      "author": "McCaffrey",
      "year": "1993",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB39",
      "doi-asserted-by": "crossref",
      "first-page": "497",
      "DOI": "10.1038/369497a0",
      "article-title": "NF-AT components define a family of transcription factors targeted in T-cell activation",
      "volume": "369",
      "author": "Northrop",
      "year": "1994",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "274",
      "DOI": "10.1016/0167-5699(94)90007-8",
      "article-title": "NF-ATp",
      "volume": "15",
      "author": "Rao",
      "year": "1994",
      "journal-title": "Immunol. Today"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB41",
      "doi-asserted-by": "crossref",
      "first-page": "707",
      "DOI": "10.1146/annurev.immunol.15.1.707",
      "article-title": "Transcription factors of the NFAT family",
      "volume": "15",
      "author": "Rao",
      "year": "1997",
      "journal-title": "Annu. Rev. Immunol"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB42",
      "doi-asserted-by": "crossref",
      "first-page": "136",
      "DOI": "10.1016/0167-5699(92)90111-J",
      "article-title": "The mechanism of action of cyclosporin A and FK506",
      "volume": "13",
      "author": "Schreiber",
      "year": "1992",
      "journal-title": "Immunol. Today"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB43",
      "doi-asserted-by": "crossref",
      "first-page": "11205",
      "DOI": "10.1073/pnas.92.24.11205",
      "article-title": "Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells",
      "volume": "92",
      "author": "Shaw",
      "year": "1995",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB44",
      "doi-asserted-by": "crossref",
      "first-page": "370",
      "DOI": "10.1038/382370a0",
      "article-title": "Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4",
      "volume": "382",
      "author": "Shibasaki",
      "year": "1996",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB45",
      "doi-asserted-by": "crossref",
      "first-page": "5076",
      "DOI": "10.1128/MCB.14.8.5076",
      "article-title": "One exon of the human LSF gene includes conserved regions involved in novel DNA-binding and dimerization",
      "volume": "14",
      "author": "Shirra",
      "year": "1994",
      "journal-title": "Mol. Cell. Biol"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB46",
      "doi-asserted-by": "crossref",
      "first-page": "619",
      "DOI": "10.1084/jem.173.3.619",
      "article-title": "Is cyclophilin involved in the immunosuppressive and nephrotoxic mechanism of action of cyclosporin A?",
      "volume": "173",
      "author": "Sigal",
      "year": "1991",
      "journal-title": "J. Exp. Med"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB47",
      "doi-asserted-by": "crossref",
      "first-page": "231",
      "DOI": "10.1038/372231a0",
      "article-title": "Signal transduction and regulation in smooth muscle",
      "volume": "372",
      "author": "Somlyo",
      "year": "1994",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB48",
      "doi-asserted-by": "crossref",
      "first-page": "15782",
      "DOI": "10.1016/S0021-9258(18)98477-2",
      "article-title": "Molecular cloning and expression of the regulatory (RGL) subunit of glycogen-associated protein phosphatase",
      "volume": "266",
      "author": "Tang",
      "year": "1991",
      "journal-title": "J. Biol. Chem"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB49",
      "doi-asserted-by": "crossref",
      "first-page": "2451",
      "DOI": "10.1074/jbc.270.6.2451",
      "article-title": "Characterization of an exchange reaction between soluble FKBP-12 and the FKBP\u00b7ryanodine receptor complex",
      "volume": "270",
      "author": "Timerman",
      "year": "1995",
      "journal-title": "J. Biol. Chem"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB50",
      "doi-asserted-by": "crossref",
      "first-page": "837",
      "DOI": "10.1038/383837a0",
      "article-title": "Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression",
      "volume": "383",
      "author": "Timmerman",
      "year": "1996",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB51",
      "doi-asserted-by": "crossref",
      "first-page": "4355",
      "DOI": "10.4049/jimmunol.145.12.4355",
      "article-title": "Transformation of T lymphocytes by the v-fos oncogene",
      "volume": "145",
      "author": "Valge-Archer",
      "year": "1990",
      "journal-title": "J. Immunol"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB52",
      "doi-asserted-by": "crossref",
      "first-page": "189",
      "DOI": "10.1016/1074-7613(94)90097-3",
      "article-title": "Cyclosporin-A sensitive induction of NF-AT in murine B cells",
      "volume": "1",
      "author": "Venkataraman",
      "year": "1994",
      "journal-title": "Immunity"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB53",
      "doi-asserted-by": "crossref",
      "first-page": "182",
      "DOI": "10.1111/j.1749-6632.1995.tb26661.x",
      "article-title": "The cyclosporin-sensitive transcription factor NFATp is expressed in several classes of cells in the immune system",
      "volume": "766",
      "author": "Wang",
      "year": "1995",
      "journal-title": "Ann. NY Acad. Sci"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB54",
      "doi-asserted-by": "crossref",
      "first-page": "435",
      "DOI": "10.1016/S0092-8674(00)80116-6",
      "article-title": "The immunophilin FKBP12 functions as a common inhibitor of the TGF\u03b2 family type I receptors",
      "volume": "86",
      "author": "Wang",
      "year": "1996",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S1097-2765(00)80063-5_BIB55",
      "doi-asserted-by": "crossref",
      "first-page": "1274",
      "DOI": "10.1074/jbc.271.3.1274",
      "article-title": "Identification of a physical interaction between calcineurin and nuclear factor of activated T cells (NFATp)",
      "volume": "271",
      "author": "Wesselborg",
      "year": "1996",
      "journal-title": "J. Biol. Chem"
    }
  ],
  "container-title": "Molecular Cell",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S1097276500800635?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S1097276500800635?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2024,
        1,
        13
      ]
    ],
    "date-time": "2024-01-13T16:44:18Z",
    "timestamp": 1705164258000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S1097276500800635"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1998,
        4
      ]
    ]
  },
  "references-count": 55,
  "journal-issue": {
    "issue": "5",
    "published-print": {
      "date-parts": [
        [
          1998,
          4
        ]
      ]
    }
  },
  "alternative-id": [
    "S1097276500800635"
  ],
  "URL": "http://dx.doi.org/10.1016/S1097-2765(00)80063-5",
  "relation": {},
  "ISSN": [
    "1097-2765"
  ],
  "subject": [],
  "container-title-short": "Molecular Cell",
  "published": {
    "date-parts": [
      [
        1998,
        4
      ]
    ]
  }
}