DOI: 10.1016/s1097-2765(00)80055-6. Cleavage of p21Cip1/Waf1 and p27Kip1 Mediates Apoptosis in Endothelial Cells through Activation of Cdk2: Role of a Caspase Cascade

Cleavage of p21Cip1/Waf1 and p27Kip1 Mediates Apoptosis in Endothelial Cells through Activation of Cdk2: Role of a Caspase Cascade

10.1016/s1097-2765(00)80055-6

Crossref journal-article

Elsevier BV

Molecular Cell (78)

Bibliography

Levkau, B., Koyama, H., Raines, E. W., Clurman, B. E., Herren, B., Orth, K., Roberts, J. M., & Ross, R. (1998). Cleavage of p21Cip1/Waf1 and p27Kip1 Mediates Apoptosis in Endothelial Cells through Activation of Cdk2: Role of a Caspase Cascade. Molecular Cell, 1(4), 553â563.

Authors 8

Bodo Levkau (first)
Hidenori Koyama (additional)
Elaine W Raines (additional)
Bruce E Clurman (additional)
Barbara Herren (additional)
Kim Orth (additional)
James M Roberts (additional)
Russell Ross (additional)

References 51 Referenced 348

10.1002/j.1460-2075.1994.tb06733.x / EMBO J / Study of the cell cycle-dependent assembly of the DNA pre-replication centres in Xenopus egg extracts by Adachi (1994)
10.1128/MCB.16.12.6623 / Mol. Cell. Biol / Identification of a cyclin-cdk2 recognition motif present in substrates and p21-like cyclin-dependent kinase inhibitors by Adams (1996)
10.1084/jem.183.5.1947 / J. Exp. Med / Proteolysis and the biochemistry of life-or-death decisions by Ashkenas (1996)
10.1016/S0960-9822(06)00029-7 / Curr. Biol / Cell-cycle arrest and inhibition of Cdk4 activity by small peptides based on the carboxy-terminal domain of p21WAF1 by Ball (1997)
10.1016/0092-8674(93)90721-2 / Cell / Reversal of terminal differentiation and control of DNA replication by Cardoso (1993)
10.1084/jem.183.5.1957 / J. Exp. Med / Apopain/CPP32 cleaves proteins that are essential for cellular repair by Casciola-Rosen (1996)
10.1038/374386a0 / Nature / Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA by Chen (1995)
10.1084/jem.181.6.2295 / J. Exp. Med / Rescue from granzyme B-induced apoptosis by Wee1 kinase by Chen (1995)
{'key': '10.1016/S1097-2765(00)80055-6_BIB9', 'first-page': '595', 'article-title': 'Characterization of p21Cip1/Waf1 peptide domains required for cyclin E/Cdk2 and PCNA interaction', 'volume': '12', 'author': 'Chen', 'year': '1996', 'journal-title': 'Oncogene'} / Oncogene / Characterization of p21Cip1/Waf1 peptide domains required for cyclin E/Cdk2 and PCNA interaction by Chen (1996)
10.1038/377446a0 / Nature / Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B by Darmon (1995)
{'key': '10.1016/S1097-2765(00)80055-6_BIB11', 'first-page': '2155', 'article-title': 'p21 contains independent binding sites for cyclin and cdk2', 'volume': '12', 'author': 'Fotedar', 'year': '1996', 'journal-title': 'Oncogene'} / Oncogene / p21 contains independent binding sites for cyclin and cdk2 by Fotedar (1996)
10.1016/0092-8674(91)90294-9 / Cell / Specific activation of cdc25 tyrosine phosphatases by B-type cyclins by Galaktionov (1991)
10.1128/MCB.16.12.6654 / Mol. Cell. Biol / Protective role of p21(Waf1/Cip1) against prostaglandin A2-mediated apoptosis of human colorectal carcinoma cells by Gorospe (1996)
10.1038/sj.onc.1200897 / Oncogene / p21(Waf1/Cip1) protects against p53-mediated apoptosis of human melanoma cells by Gorospe (1997)
10.1002/j.1460-2075.1992.tb05493.x / EMBO J / Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15 by Gu (1992)
10.1016/S0092-8674(00)81347-1 / Cell / Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA by Gulbis (1996)
10.1016/0092-8674(94)90543-6 / Cell / Cyclins and cancer II by Hunter (1994)
10.1002/jcb.240580206 / J. Cell. Biochem / Cell cycle and apoptosis by King (1995)
10.1016/S0092-8674(00)81801-2 / Cell / Fibrillar collagen inhibits arterial smooth muscle proliferation through regulation of CDK2 inhibitors by Koyama (1996)
{'key': '10.1016/S1097-2765(00)80055-6_BIB20', 'first-page': '1597', 'article-title': 'Rapid and efficient site-directed mutagenesis without phenotypic selection', 'volume': '154', 'author': 'Kunkel', 'year': '1987', 'journal-title': 'Meth. Enzymol'} / Meth. Enzymol / Rapid and efficient site-directed mutagenesis without phenotypic selection by Kunkel (1987)
10.1038/371534a0 / Nature / Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair by Li (1994)
10.1126/science.7716549 / Science / Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein by Li (1995)
10.1002/(SICI)1097-4644(199701)64:1<19::AID-JCB4>3.0.CO;2-2 / J. Cell. Biochem / In vitro and in vivo studies of ICE inhibitors by Livingston (1997)
10.1038/375159a0 / Nature / Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1 by Luo (1995)
10.1002/jcb.240580205 / J. Cell. Biochem / Apoptosis and the cell cycle by Meikrantz (1995)
10.1074/jbc.271.17.10205 / J. Biol. Chem / Suppression of apoptosis by dominant negative mutants of cyclin-dependent protein kinases by Meikrantz (1996)
10.1073/pnas.91.9.3754 / Proc. Natl. Acad. Sci. USA / Activation of cyclin A-dependent protein kinases during apoptosis by Meikrantz (1994)
10.1038/374131a0 / Nature / Principles of CDK regulation by Morgan (1995)
10.1038/376037a0 / Nature / Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis by Nicholson (1995)
10.1074/jbc.271.35.20977 / J. Biol. Chem / Molecular ordering of apoptotic mammalian CED-3/ICE-like proteases by Orth (1996)
10.1074/jbc.271.14.8161 / J. Biol. Chem / Inhibitors of cyclin-dependent kinases promote survival of post-mitotic neuronally differentiated PC12 cells and sympathetic neurons by Park (1996)
10.1083/jcb.115.1.1 / J. Cell. Biol / Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport by Pines (1991)
10.1128/MCB.16.4.1335 / Mol. Cell. Biol / The cyclin-dependent kinase inhibitor p21 (WAF1) is required for survival of differentiating neuroblastoma cells by Poluha (1996)
10.1101/gad.10.15.1945 / Genes Dev / Genetic determinants of p53-induced apoptosis and growth arrest by Polyak (1996)
{'key': '10.1016/S1097-2765(00)80055-6_BIB34', 'first-page': '73', 'article-title': 'Cdk2 kinase phosphorylates serine 315 of human p53 in vitro', 'volume': '11', 'author': 'Price', 'year': '1995', 'journal-title': 'Oncogene'} / Oncogene / Cdk2 kinase phosphorylates serine 315 of human p53 in vitro by Price (1995)
10.1083/jcb.127.2.537 / J. Cell Biol / Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells by Re (1994)
10.1016/S0092-8674(00)80430-4 / Cell / Caspases by Salvesen (1997)
10.1038/366704a0 / Nature / A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4 by Serrano (1993)
10.1126/science.7809631 / Science / Inhibition of ras-induced proliferation and cellular transformation by p16INK4 by Serrano (1995)
10.1016/0092-8674(93)90636-5 / Cell / Mammalian G1 cyclins by Sherr (1993)
10.1101/gad.9.10.1149 / Genes Dev / Inhibitors of mammalian G1 cyclin-dependent kinases by Sherr (1995)
10.1126/science.8108732 / Science / Premature p34cdc2 activation required for apoptosis by Shi (1994)
10.4049/jimmunol.157.6.2381 / J. Immunol / Granzyme B induces apoptosis and cyclin A-associated cyclin-dependent kinase activity in all stages of the cell cycle by Shi (1996)
10.1074/jbc.272.15.9677 / J. Biol. Chem / Substrate specificities of caspase family proteases by Talanian (1997)
10.1038/356768a0 / Nature / A novel heterodimeric cysteine protease is required for interleukin-1beta processing in monocytes by Thornberry (1992)
10.1074/jbc.272.29.17907 / J. Biol. Chem / A combinatorial approach defines specificities of members of the caspase family and granzyme B by Thornberry (1997)
10.1038/376088a0 / Nature / Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases by Wang (1995)
10.1126/science.273.5273.359 / Science / Resistance to apoptosis conferred by cdk inhibitors during myocyte differentiation by Wang (1996)
{'key': '10.1016/S1097-2765(00)80055-6_BIB48', 'first-page': '927', 'article-title': 'Apoptosis in 7-hydroxystaurosporine-treated T lymphoblasts correlates with activation of cyclin-dependent kinases 1 and 2', 'volume': '6', 'author': 'Wang', 'year': '1995', 'journal-title': 'Cell. Growth. Differ'} / Cell. Growth. Differ / Apoptosis in 7-hydroxystaurosporine-treated T lymphoblasts correlates with activation of cyclin-dependent kinases 1 and 2 by Wang (1995)
10.1016/S0960-9822(95)00058-3 / Curr. Biol / A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen by Warbrick (1995)
10.1101/gad.8.15.1750 / Genes Dev / p21-containing cyclin kinases exist in both active and inactive states by Zhang (1994)

Dates

Type	When
Created	21 years, 3 months ago (May 4, 2004, 8:29 a.m.)
Deposited	1 year, 7 months ago (Jan. 13, 2024, 4:15 a.m.)
Indexed	1 month ago (July 26, 2025, 4:43 a.m.)
Issued	27 years, 5 months ago (March 1, 1998)
Published	27 years, 5 months ago (March 1, 1998)
Published Print	27 years, 5 months ago (March 1, 1998)

Funders 0

None

BibTeX

@article{Levkau_1998, title={Cleavage of p21Cip1/Waf1 and p27Kip1 Mediates Apoptosis in Endothelial Cells through Activation of Cdk2: Role of a Caspase Cascade}, volume={1}, ISSN={1097-2765}, url={http://dx.doi.org/10.1016/s1097-2765(00)80055-6}, DOI={10.1016/s1097-2765(00)80055-6}, number={4}, journal={Molecular Cell}, publisher={Elsevier BV}, author={Levkau, Bodo and Koyama, Hidenori and Raines, Elaine W and Clurman, Bruce E and Herren, Barbara and Orth, Kim and Roberts, James M and Ross, Russell}, year={1998}, month=mar, pages={553–563} }

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      "article-title": "Proteolysis and the biochemistry of life-or-death decisions",
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      "journal-title": "J. Exp. Med"
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      "volume": "7",
      "author": "Ball",
      "year": "1997",
      "journal-title": "Curr. Biol"
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      "article-title": "Apopain/CPP32 cleaves proteins that are essential for cellular repair",
      "volume": "183",
      "author": "Casciola-Rosen",
      "year": "1996",
      "journal-title": "J. Exp. Med"
    },
    {
      "key": "10.1016/S1097-2765(00)80055-6_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "386",
      "DOI": "10.1038/374386a0",
      "article-title": "Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA",
      "volume": "374",
      "author": "Chen",
      "year": "1995",
      "journal-title": "Nature"
    },
    {
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      "volume": "181",
      "author": "Chen",
      "year": "1995",
      "journal-title": "J. Exp. Med"
    },
    {
      "key": "10.1016/S1097-2765(00)80055-6_BIB9",
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      "author": "Chen",
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      "article-title": "Suppression of apoptosis by dominant negative mutants of cyclin-dependent protein kinases",
      "volume": "271",
      "author": "Meikrantz",
      "year": "1996",
      "journal-title": "J. Biol. Chem"
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      "first-page": "3754",
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      "article-title": "Activation of cyclin A-dependent protein kinases during apoptosis",
      "volume": "91",
      "author": "Meikrantz",
      "year": "1994",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
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      "first-page": "131",
      "DOI": "10.1038/374131a0",
      "article-title": "Principles of CDK regulation",
      "volume": "374",
      "author": "Morgan",
      "year": "1995",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S1097-2765(00)80055-6_BIB28",
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      "first-page": "37",
      "DOI": "10.1038/376037a0",
      "article-title": "Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis",
      "volume": "376",
      "author": "Nicholson",
      "year": "1995",
      "journal-title": "Nature"
    },
    {
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      "first-page": "20977",
      "DOI": "10.1074/jbc.271.35.20977",
      "article-title": "Molecular ordering of apoptotic mammalian CED-3/ICE-like proteases",
      "volume": "271",
      "author": "Orth",
      "year": "1996",
      "journal-title": "J. Biol. Chem"
    },
    {
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      "first-page": "8161",
      "DOI": "10.1074/jbc.271.14.8161",
      "article-title": "Inhibitors of cyclin-dependent kinases promote survival of post-mitotic neuronally differentiated PC12 cells and sympathetic neurons",
      "volume": "271",
      "author": "Park",
      "year": "1996",
      "journal-title": "J. Biol. Chem"
    },
    {
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      "first-page": "1",
      "DOI": "10.1083/jcb.115.1.1",
      "article-title": "Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport",
      "volume": "115",
      "author": "Pines",
      "year": "1991",
      "journal-title": "J. Cell. Biol"
    },
    {
      "key": "10.1016/S1097-2765(00)80055-6_BIB32",
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      "first-page": "1335",
      "DOI": "10.1128/MCB.16.4.1335",
      "article-title": "The cyclin-dependent kinase inhibitor p21 (WAF1) is required for survival of differentiating neuroblastoma cells",
      "volume": "16",
      "author": "Poluha",
      "year": "1996",
      "journal-title": "Mol. Cell. Biol"
    },
    {
      "key": "10.1016/S1097-2765(00)80055-6_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "1945",
      "DOI": "10.1101/gad.10.15.1945",
      "article-title": "Genetic determinants of p53-induced apoptosis and growth arrest",
      "volume": "10",
      "author": "Polyak",
      "year": "1996",
      "journal-title": "Genes Dev"
    },
    {
      "key": "10.1016/S1097-2765(00)80055-6_BIB34",
      "first-page": "73",
      "article-title": "Cdk2 kinase phosphorylates serine 315 of human p53 in vitro",
      "volume": "11",
      "author": "Price",
      "year": "1995",
      "journal-title": "Oncogene"
    },
    {
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      "first-page": "537",
      "DOI": "10.1083/jcb.127.2.537",
      "article-title": "Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells",
      "volume": "127",
      "author": "Re",
      "year": "1994",
      "journal-title": "J. Cell Biol"
    },
    {
      "key": "10.1016/S1097-2765(00)80055-6_BIB36",
      "doi-asserted-by": "crossref",
      "first-page": "443",
      "DOI": "10.1016/S0092-8674(00)80430-4",
      "article-title": "Caspases",
      "volume": "91",
      "author": "Salvesen",
      "year": "1997",
      "journal-title": "Cell"
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      "first-page": "704",
      "DOI": "10.1038/366704a0",
      "article-title": "A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4",
      "volume": "366",
      "author": "Serrano",
      "year": "1993",
      "journal-title": "Nature"
    },
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      "first-page": "249",
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      "volume": "267",
      "author": "Serrano",
      "year": "1995",
      "journal-title": "Science"
    },
    {
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      "DOI": "10.1016/0092-8674(93)90636-5",
      "article-title": "Mammalian G1 cyclins",
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      "author": "Sherr",
      "year": "1993",
      "journal-title": "Cell"
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      "first-page": "1149",
      "DOI": "10.1101/gad.9.10.1149",
      "article-title": "Inhibitors of mammalian G1 cyclin-dependent kinases",
      "volume": "9",
      "author": "Sherr",
      "year": "1995",
      "journal-title": "Genes Dev"
    },
    {
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      "DOI": "10.1126/science.8108732",
      "article-title": "Premature p34cdc2 activation required for apoptosis",
      "volume": "263",
      "author": "Shi",
      "year": "1994",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S1097-2765(00)80055-6_BIB42",
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      "first-page": "2381",
      "DOI": "10.4049/jimmunol.157.6.2381",
      "article-title": "Granzyme B induces apoptosis and cyclin A-associated cyclin-dependent kinase activity in all stages of the cell cycle",
      "volume": "157",
      "author": "Shi",
      "year": "1996",
      "journal-title": "J. Immunol"
    },
    {
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      "first-page": "9677",
      "DOI": "10.1074/jbc.272.15.9677",
      "article-title": "Substrate specificities of caspase family proteases",
      "volume": "272",
      "author": "Talanian",
      "year": "1997",
      "journal-title": "J. Biol. Chem"
    },
    {
      "key": "10.1016/S1097-2765(00)80055-6_BIB44",
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      "first-page": "768",
      "DOI": "10.1038/356768a0",
      "article-title": "A novel heterodimeric cysteine protease is required for interleukin-1beta processing in monocytes",
      "volume": "356",
      "author": "Thornberry",
      "year": "1992",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S1097-2765(00)80055-6_BIB45",
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      "DOI": "10.1074/jbc.272.29.17907",
      "article-title": "A combinatorial approach defines specificities of members of the caspase family and granzyme B",
      "volume": "272",
      "author": "Thornberry",
      "year": "1997",
      "journal-title": "J. Biol. Chem"
    },
    {
      "key": "10.1016/S1097-2765(00)80055-6_BIB46",
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      "first-page": "88",
      "DOI": "10.1038/376088a0",
      "article-title": "Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases",
      "volume": "376",
      "author": "Wang",
      "year": "1995",
      "journal-title": "Nature"
    },
    {
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      "first-page": "359",
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      "article-title": "Resistance to apoptosis conferred by cdk inhibitors during myocyte differentiation",
      "volume": "273",
      "author": "Wang",
      "year": "1996",
      "journal-title": "Science"
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      "key": "10.1016/S1097-2765(00)80055-6_BIB48",
      "first-page": "927",
      "article-title": "Apoptosis in 7-hydroxystaurosporine-treated T lymphoblasts correlates with activation of cyclin-dependent kinases 1 and 2",
      "volume": "6",
      "author": "Wang",
      "year": "1995",
      "journal-title": "Cell. Growth. Differ"
    },
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      "DOI": "10.1016/S0960-9822(95)00058-3",
      "article-title": "A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen",
      "volume": "5",
      "author": "Warbrick",
      "year": "1995",
      "journal-title": "Curr. Biol"
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      "DOI": "10.1101/gad.8.15.1750",
      "article-title": "p21-containing cyclin kinases exist in both active and inactive states",
      "volume": "8",
      "author": "Zhang",
      "year": "1994",
      "journal-title": "Genes Dev"
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