DOI: 10.1016/s1074-7613(03)00234-6. The Structure of a Bcl-xL/Bim Fragment Complex

The Structure of a Bcl-xL/Bim Fragment Complex

10.1016/s1074-7613(03)00234-6

Crossref journal-article

Elsevier BV

Immunity (78)

Bibliography

Liu, X., Dai, S., Zhu, Y., Marrack, P., & Kappler, J. W. (2003). The Structure of a Bcl-xL/Bim Fragment Complex. Immunity, 19(3), 341â352.

Authors 5

Xinqi Liu (first)
Shaodong Dai (additional)
Yanan Zhu (additional)
Philippa Marrack (additional)
John W Kappler (additional)

References 63 Referenced 311

10.1126/science.281.5381.1322 / Science / The Bcl-2 protein family by Adams (1998)
10.1016/0167-5699(93)90181-J / Immunol. Today / A possible role for bcl-2 in regulating T-cell memory–a `balancing act' between cell death and survival by Akbar (1993)
10.1126/science.277.5324.370 / Science / Inhibition of Bax channel-forming activity by Bcl-2 by Antonsson (1997)
{'key': '10.1016/S1074-7613(03)00234-6_BIB4', 'first-page': '27886', 'article-title': 'Crystal structure of rat Bcl-xL', 'volume': '2', 'author': 'Aritomi', 'year': '1997', 'journal-title': 'Implications for the function of the Bcl-'} / Implications for the function of the Bcl- / Crystal structure of rat Bcl-xL by Aritomi (1997)
{'key': '10.1016/S1074-7613(03)00234-6_BIB5', 'first-page': '541', 'article-title': 'Bcl-2 and Bax modulate adenine nucleotide translocase activity', 'volume': '63', 'author': 'Belzacq', 'year': '2003', 'journal-title': 'Cancer Res.'} / Cancer Res. / Bcl-2 and Bax modulate adenine nucleotide translocase activity by Belzacq (2003)
10.1038/ni1002-893 / Nat. Immunol. / Bax and Bak by Bouillet (2002)
10.1038/415922a / Nature / BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes by Bouillet (2002)
10.1038/sj.onc.1203298 / Oncogene / Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator by Brenner (2000)
10.1107/S0907444998003254 / Acta Crystallogr. D Biol. Crystallogr. / Crystallography & NMR system by Brunger (1998)
CCP4 (Collaborative Computational Project 4) (1994). The CCP4 suite: programs for protein crystallography. Acta. Crystallogr. D 50, 760–763. (10.1107/S0907444994003112)
10.1093/emboj/16.5.968 / EMBO J. / Identification of a novel regulatory domain in Bcl-X(L) and Bcl-2 by Chang (1997)
10.1084/jem.20020827 / J. Exp. Med. / Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by Bim by Davey (2002)
10.1083/jcb.144.5.891 / J. Cell Biol. / Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis by Desagher (1999)
10.1016/S0006-291X(02)02544-5 / Biochem. Biophys. Res. Commun. / Direct evidence for membrane pore formation by the apoptotic protein Bax by Epand (2002)
10.1128/MCB.20.3.929-935.2000 / Mol. Cell. Biol. / Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane by Eskes (2000)
10.1006/jmbi.2000.4374 / J. Mol. Biol. / Structural basis of diverse sequence-dependent target recognition by the 8 kDa dynein light chain by Fan (2001)
10.1083/jcb.143.1.207 / J. Cell Biol. / Regulated targeting of BAX to mitochondria by Goping (1998)
10.1083/jcb.144.5.903 / J. Cell Biol. / Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis by Griffiths (1999)
10.1101/gad.13.15.1899 / Genes Dev. / BCL-2 family members and the mitochondria in apoptosis by Gross (1999)
10.1002/elps.1150181505 / Electrophoresis / SWISS-MODEL and the Swiss-PdbViewer by Guex (1997)
10.1016/S1074-7613(02)00322-9 / Immunity / Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim by Hildeman (2002)
10.1093/emboj/cdg144 / EMBO J. / The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity by Hinds (2003)
10.1074/jbc.272.21.13829 / J. Biol. Chem. / Nonionic detergents induce dimerization among members of the Bcl-2 family by Hsu (1997)
10.1074/jbc.273.17.10777 / J. Biol. Chem. / Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations by Hsu (1998)
10.1073/pnas.95.9.4997 / Proc. Natl. Acad. Sci. USA / Bax directly induces release of cytochrome c from isolated mitochondria by Jurgensmeier (1998)
10.1038/349245a0 / Nature / Programmed cell death and extrathymic reduction of Vbeta8+ CD4+ T cells in mice tolerant to Staphylococcus aureus enterotoxin B by Kawabe (1991)
10.1016/1074-7613(94)90084-1 / Immunity / Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo by Kearney (1994)
10.1038/sj.cdd.4400783 / Cell Death Differ. / Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c by Korsmeyer (2000)
10.1038/369151a0 / Nature / Production of soluble MHC class II proteins with covalently bound single peptides by Kozono (1994)
10.1016/S0092-8674(02)01036-X / Cell / Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane by Kuwana (2002)
10.1016/S1535-6108(02)00127-7 / Cancer Cell / Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics by Letai (2002)
10.1016/S1097-2765(00)00136-2 / Mol. Cell / The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues by Lindsten (2000)
{'author': 'Martz', 'key': '10.1016/S1074-7613(03)00234-6_BIB33'} by Martz
10.1016/S0092-8674(00)80573-5 / Cell / Solution structure of the proapoptotic molecule BID by McDonnell (1999)
10.1074/jbc.M100655200 / J. Biol. Chem. / Bcl-2 prevents Bax oligomerization in the mitochondrial outer membrane by Mikhailov (2001)
10.1074/jbc.M203392200 / J. Biol. Chem. / Association of Bax and Bak homo-oligomers in mitochondria. Bax requirement for Bak reorganization and cytochrome c release by Mikhailov (2003)
10.1038/381335a0 / Nature / X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death by Muchmore (1996)
10.1073/pnas.95.25.14681 / Proc. Natl. Acad. Sci. USA / Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria by Narita (1998)
10.1107/S0907444901012422 / Acta Crystallogr. D Biol. Crystallogr. / Implementation of molecular replacement in AMoRe by Navaza (2001)
10.1093/emboj/18.9.2330 / EMBO J. / Conformation of the Bax C-terminus regulates subcellular location and cell death by Nechushtan (1999)
10.4049/jimmunol.157.2.636 / J. Immunol. / CD28 costimulation prevents cell death during primary T cell activation by Noel (1996)
10.1093/emboj/17.2.384 / EMBO J. / Bim by O'Connor (1998)
{'key': '10.1016/S1074-7613(03)00234-6_BIB43', 'series-title': 'Macromolecular Crystallography Part A', 'article-title': 'Processing of X-ray diffraction data dollected in oscillation mode', 'author': 'Otwinowski', 'year': '1997'} / Macromolecular Crystallography Part A / Processing of X-ray diffraction data dollected in oscillation mode by Otwinowski (1997)
10.1017/S096183680000331X / Protein Sci. / Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies by Petros (2000)
10.1073/pnas.041619798 / Proc. Natl. Acad. Sci. USA / Solution structure of the antiapoptotic protein bcl-2 by Petros (2001)
10.1002/(SICI)1521-4141(199802)28:02<560::AID-IMMU560>3.0.CO;2-Q / Eur. J. Immunol. / Constitutive expression of Bcl-xL or Bcl-2 prevents peptide antigen-induced T cell deletion but does not influence T cell homeostasis after a viral infection by Petschner (1998)
10.1016/S1097-2765(00)80456-6 / Mol. Cell / The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex by Puthalakath (1999)
10.1038/ni834 / Nat. Immunol. / Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis by Rathmell (2002)
10.1007/978-1-4899-0274-0_10 / Adv. Exp. Med. Biol. / Structure-function analysis of Bcl-2 family proteins. Regulators of programmed cell death by Reed (1996)
10.1042/bj20020972 / Biochem. J. / Bax oligomerization in mitochondrial membranes requires tBid (caspase-8-cleaved Bid) and a mitochondrial protein by Roucou (2002)
10.1038/sj.cdd.4400739 / Cell Death Differ. / BID-dependent and BID-independent pathways for BAX insertion into mitochondria by Ruffolo (2000)
10.1126/science.275.5302.983 / Science / Structure of Bcl-xL-Bak peptide complex by Sattler (1997)
10.1038/20959 / Nature / Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC by Shimizu (1999)
10.1038/sj.onc.1205621 / Oncogene / Activation of mitochondrial voltage-dependent anion channel by a pro-apoptotic BH3-only protein Bim by Sugiyama (2002)
10.1128/JVI.75.16.7506-7516.2001 / J. Virol. / E1B 19K blocks Bax oligomerization and tumor necrosis factor alpha-mediated apoptosis by Sundararajan (2001)
10.1016/S0092-8674(00)00167-7 / Cell / Structure of Bax by Suzuki (2000)
10.1016/1074-7613(95)90050-0 / Immunity / Lipopolysaccharide interferes with the induction of peripheral T cell death by Vella (1995)
10.1101/gad.10.22.2859 / Genes Dev. / Bid by Wang (1996)
{'key': '10.1016/S1074-7613(03)00234-6_BIB59', 'first-page': '329', 'article-title': 'Factors influencing the fate of T cells responding to Mls antigens', 'volume': '4', 'author': 'Webb', 'year': '1992', 'journal-title': 'Semin. Immunol.'} / Semin. Immunol. / Factors influencing the fate of T cells responding to Mls antigens by Webb (1992)
10.1101/gad.14.16.2060 / Genes Dev. / tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c by Wei (2000)
10.1126/science.1059108 / Science / Proapoptotic BAX and BAK by Wei (2001)
10.1074/jbc.271.13.7440 / J. Biol. Chem. / Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2 by Zha (1996)
10.1074/jbc.272.39.24101 / J. Biol. Chem. / BH3 domain of BAD is required for heterodimerization with BCL-XL and pro-apoptotic activity by Zha (1997)

Dates

Type	When
Created	21 years, 4 months ago (April 15, 2004, 5:36 a.m.)
Deposited	2 years, 3 months ago (April 28, 2023, 4:02 a.m.)
Indexed	2 months ago (June 19, 2025, 12:04 p.m.)
Issued	21 years, 11 months ago (Sept. 1, 2003)
Published	21 years, 11 months ago (Sept. 1, 2003)
Published Print	21 years, 11 months ago (Sept. 1, 2003)

Funders 0

None

BibTeX

@article{Liu_2003, title={The Structure of a Bcl-xL/Bim Fragment Complex}, volume={19}, ISSN={1074-7613}, url={http://dx.doi.org/10.1016/s1074-7613(03)00234-6}, DOI={10.1016/s1074-7613(03)00234-6}, number={3}, journal={Immunity}, publisher={Elsevier BV}, author={Liu, Xinqi and Dai, Shaodong and Zhu, Yanan and Marrack, Philippa and Kappler, John W}, year={2003}, month=sep, pages={341–352} }

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      "volume": "95",
      "author": "Jurgensmeier",
      "year": "1998",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
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      "first-page": "245",
      "DOI": "10.1038/349245a0",
      "article-title": "Programmed cell death and extrathymic reduction of Vbeta8+ CD4+ T cells in mice tolerant to Staphylococcus aureus enterotoxin B",
      "volume": "349",
      "author": "Kawabe",
      "year": "1991",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S1074-7613(03)00234-6_BIB27",
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      "first-page": "327",
      "DOI": "10.1016/1074-7613(94)90084-1",
      "article-title": "Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo",
      "volume": "1",
      "author": "Kearney",
      "year": "1994",
      "journal-title": "Immunity"
    },
    {
      "key": "10.1016/S1074-7613(03)00234-6_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "1166",
      "DOI": "10.1038/sj.cdd.4400783",
      "article-title": "Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c",
      "volume": "7",
      "author": "Korsmeyer",
      "year": "2000",
      "journal-title": "Cell Death Differ."
    },
    {
      "key": "10.1016/S1074-7613(03)00234-6_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "151",
      "DOI": "10.1038/369151a0",
      "article-title": "Production of soluble MHC class II proteins with covalently bound single peptides",
      "volume": "369",
      "author": "Kozono",
      "year": "1994",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S1074-7613(03)00234-6_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "331",
      "DOI": "10.1016/S0092-8674(02)01036-X",
      "article-title": "Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane",
      "volume": "111",
      "author": "Kuwana",
      "year": "2002",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S1074-7613(03)00234-6_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "183",
      "DOI": "10.1016/S1535-6108(02)00127-7",
      "article-title": "Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics",
      "volume": "2",
      "author": "Letai",
      "year": "2002",
      "journal-title": "Cancer Cell"
    },
    {
      "key": "10.1016/S1074-7613(03)00234-6_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "1389",
      "DOI": "10.1016/S1097-2765(00)00136-2",
      "article-title": "The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues",
      "volume": "6",
      "author": "Lindsten",
      "year": "2000",
      "journal-title": "Mol. Cell"
    },
    {
      "author": "Martz",
      "key": "10.1016/S1074-7613(03)00234-6_BIB33"
    },
    {
      "key": "10.1016/S1074-7613(03)00234-6_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "625",
      "DOI": "10.1016/S0092-8674(00)80573-5",
      "article-title": "Solution structure of the proapoptotic molecule BID",
      "volume": "96",
      "author": "McDonnell",
      "year": "1999",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S1074-7613(03)00234-6_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "18361",
      "DOI": "10.1074/jbc.M100655200",
      "article-title": "Bcl-2 prevents Bax oligomerization in the mitochondrial outer membrane",
      "volume": "276",
      "author": "Mikhailov",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1074-7613(03)00234-6_BIB36",
      "doi-asserted-by": "crossref",
      "first-page": "5367",
      "DOI": "10.1074/jbc.M203392200",
      "article-title": "Association of Bax and Bak homo-oligomers in mitochondria. Bax requirement for Bak reorganization and cytochrome c release",
      "volume": "278",
      "author": "Mikhailov",
      "year": "2003",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1074-7613(03)00234-6_BIB37",
      "doi-asserted-by": "crossref",
      "first-page": "335",
      "DOI": "10.1038/381335a0",
      "article-title": "X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death",
      "volume": "381",
      "author": "Muchmore",
      "year": "1996",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S1074-7613(03)00234-6_BIB38",
      "doi-asserted-by": "crossref",
      "first-page": "14681",
      "DOI": "10.1073/pnas.95.25.14681",
      "article-title": "Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria",
      "volume": "95",
      "author": "Narita",
      "year": "1998",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S1074-7613(03)00234-6_BIB39",
      "doi-asserted-by": "crossref",
      "first-page": "1367",
      "DOI": "10.1107/S0907444901012422",
      "article-title": "Implementation of molecular replacement in AMoRe",
      "volume": "57",
      "author": "Navaza",
      "year": "2001",
      "journal-title": "Acta Crystallogr. D Biol. Crystallogr."
    },
    {
      "key": "10.1016/S1074-7613(03)00234-6_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "2330",
      "DOI": "10.1093/emboj/18.9.2330",
      "article-title": "Conformation of the Bax C-terminus regulates subcellular location and cell death",
      "volume": "18",
      "author": "Nechushtan",
      "year": "1999",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/S1074-7613(03)00234-6_BIB41",
      "doi-asserted-by": "crossref",
      "first-page": "636",
      "DOI": "10.4049/jimmunol.157.2.636",
      "article-title": "CD28 costimulation prevents cell death during primary T cell activation",
      "volume": "157",
      "author": "Noel",
      "year": "1996",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/S1074-7613(03)00234-6_BIB42",
      "doi-asserted-by": "crossref",
      "first-page": "384",
      "DOI": "10.1093/emboj/17.2.384",
      "article-title": "Bim",
      "volume": "17",
      "author": "O'Connor",
      "year": "1998",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/S1074-7613(03)00234-6_BIB43",
      "series-title": "Macromolecular Crystallography Part A",
      "article-title": "Processing of X-ray diffraction data dollected in oscillation mode",
      "author": "Otwinowski",
      "year": "1997"
    },
    {
      "key": "10.1016/S1074-7613(03)00234-6_BIB44",
      "doi-asserted-by": "crossref",
      "first-page": "2528",
      "DOI": "10.1017/S096183680000331X",
      "article-title": "Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies",
      "volume": "9",
      "author": "Petros",
      "year": "2000",
      "journal-title": "Protein Sci."
    },
    {
      "key": "10.1016/S1074-7613(03)00234-6_BIB45",
      "doi-asserted-by": "crossref",
      "first-page": "3012",
      "DOI": "10.1073/pnas.041619798",
      "article-title": "Solution structure of the antiapoptotic protein bcl-2",
      "volume": "98",
      "author": "Petros",
      "year": "2001",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S1074-7613(03)00234-6_BIB46",
      "doi-asserted-by": "crossref",
      "first-page": "560",
      "DOI": "10.1002/(SICI)1521-4141(199802)28:02<560::AID-IMMU560>3.0.CO;2-Q",
      "article-title": "Constitutive expression of Bcl-xL or Bcl-2 prevents peptide antigen-induced T cell deletion but does not influence T cell homeostasis after a viral infection",
      "volume": "28",
      "author": "Petschner",
      "year": "1998",
      "journal-title": "Eur. J. Immunol."
    },
    {
      "key": "10.1016/S1074-7613(03)00234-6_BIB47",
      "doi-asserted-by": "crossref",
      "first-page": "287",
      "DOI": "10.1016/S1097-2765(00)80456-6",
      "article-title": "The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex",
      "volume": "3",
      "author": "Puthalakath",
      "year": "1999",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/S1074-7613(03)00234-6_BIB48",
      "doi-asserted-by": "crossref",
      "first-page": "932",
      "DOI": "10.1038/ni834",
      "article-title": "Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis",
      "volume": "3",
      "author": "Rathmell",
      "year": "2002",
      "journal-title": "Nat. Immunol."
    },
    {
      "key": "10.1016/S1074-7613(03)00234-6_BIB49",
      "doi-asserted-by": "crossref",
      "first-page": "99",
      "DOI": "10.1007/978-1-4899-0274-0_10",
      "article-title": "Structure-function analysis of Bcl-2 family proteins. Regulators of programmed cell death",
      "volume": "406",
      "author": "Reed",
      "year": "1996",
      "journal-title": "Adv. Exp. Med. Biol."
    },
    {
      "key": "10.1016/S1074-7613(03)00234-6_BIB50",
      "doi-asserted-by": "crossref",
      "first-page": "915",
      "DOI": "10.1042/bj20020972",
      "article-title": "Bax oligomerization in mitochondrial membranes requires tBid (caspase-8-cleaved Bid) and a mitochondrial protein",
      "volume": "368",
      "author": "Roucou",
      "year": "2002",
      "journal-title": "Biochem. J."
    },
    {
      "key": "10.1016/S1074-7613(03)00234-6_BIB51",
      "doi-asserted-by": "crossref",
      "first-page": "1101",
      "DOI": "10.1038/sj.cdd.4400739",
      "article-title": "BID-dependent and BID-independent pathways for BAX insertion into mitochondria",
      "volume": "7",
      "author": "Ruffolo",
      "year": "2000",
      "journal-title": "Cell Death Differ."
    },
    {
      "key": "10.1016/S1074-7613(03)00234-6_BIB52",
      "doi-asserted-by": "crossref",
      "first-page": "983",
      "DOI": "10.1126/science.275.5302.983",
      "article-title": "Structure of Bcl-xL-Bak peptide complex",
      "volume": "275",
      "author": "Sattler",
      "year": "1997",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S1074-7613(03)00234-6_BIB53",
      "doi-asserted-by": "crossref",
      "first-page": "483",
      "DOI": "10.1038/20959",
      "article-title": "Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC",
      "volume": "399",
      "author": "Shimizu",
      "year": "1999",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S1074-7613(03)00234-6_BIB54",
      "doi-asserted-by": "crossref",
      "first-page": "4944",
      "DOI": "10.1038/sj.onc.1205621",
      "article-title": "Activation of mitochondrial voltage-dependent anion channel by a pro-apoptotic BH3-only protein Bim",
      "volume": "21",
      "author": "Sugiyama",
      "year": "2002",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/S1074-7613(03)00234-6_BIB55",
      "doi-asserted-by": "crossref",
      "first-page": "7506",
      "DOI": "10.1128/JVI.75.16.7506-7516.2001",
      "article-title": "E1B 19K blocks Bax oligomerization and tumor necrosis factor alpha-mediated apoptosis",
      "volume": "75",
      "author": "Sundararajan",
      "year": "2001",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/S1074-7613(03)00234-6_BIB56",
      "doi-asserted-by": "crossref",
      "first-page": "645",
      "DOI": "10.1016/S0092-8674(00)00167-7",
      "article-title": "Structure of Bax",
      "volume": "103",
      "author": "Suzuki",
      "year": "2000",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S1074-7613(03)00234-6_BIB57",
      "doi-asserted-by": "crossref",
      "first-page": "261",
      "DOI": "10.1016/1074-7613(95)90050-0",
      "article-title": "Lipopolysaccharide interferes with the induction of peripheral T cell death",
      "volume": "2",
      "author": "Vella",
      "year": "1995",
      "journal-title": "Immunity"
    },
    {
      "key": "10.1016/S1074-7613(03)00234-6_BIB58",
      "doi-asserted-by": "crossref",
      "first-page": "2859",
      "DOI": "10.1101/gad.10.22.2859",
      "article-title": "Bid",
      "volume": "10",
      "author": "Wang",
      "year": "1996",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/S1074-7613(03)00234-6_BIB59",
      "first-page": "329",
      "article-title": "Factors influencing the fate of T cells responding to Mls antigens",
      "volume": "4",
      "author": "Webb",
      "year": "1992",
      "journal-title": "Semin. Immunol."
    },
    {
      "key": "10.1016/S1074-7613(03)00234-6_BIB60",
      "doi-asserted-by": "crossref",
      "first-page": "2060",
      "DOI": "10.1101/gad.14.16.2060",
      "article-title": "tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c",
      "volume": "14",
      "author": "Wei",
      "year": "2000",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/S1074-7613(03)00234-6_BIB61",
      "doi-asserted-by": "crossref",
      "first-page": "727",
      "DOI": "10.1126/science.1059108",
      "article-title": "Proapoptotic BAX and BAK",
      "volume": "292",
      "author": "Wei",
      "year": "2001",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S1074-7613(03)00234-6_BIB62",
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      "first-page": "7440",
      "DOI": "10.1074/jbc.271.13.7440",
      "article-title": "Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2",
      "volume": "271",
      "author": "Zha",
      "year": "1996",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S1074-7613(03)00234-6_BIB63",
      "doi-asserted-by": "crossref",
      "first-page": "24101",
      "DOI": "10.1074/jbc.272.39.24101",
      "article-title": "BH3 domain of BAD is required for heterodimerization with BCL-XL and pro-apoptotic activity",
      "volume": "272",
      "author": "Zha",
      "year": "1997",
      "journal-title": "J. Biol. Chem."
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