DOI: 10.1016/s1074-7613(00)80059-x. Granzyme A Initiates an Alternative Pathway for Granule-Mediated Apoptosis

Granzyme A Initiates an Alternative Pathway for Granule-Mediated Apoptosis

10.1016/s1074-7613(00)80059-x

Crossref journal-article

Elsevier BV

Immunity (78)

Bibliography

Shresta, S., Graubert, T. A., Thomas, D. A., Raptis, S. Z., & Ley, T. J. (1999). Granzyme A Initiates an Alternative Pathway for Granule-Mediated Apoptosis. Immunity, 10(5), 595â605.

Authors 5

Sujan Shresta (first)
Timothy A Graubert (additional)
Dori A Thomas (additional)
Sofia Z Raptis (additional)
Timothy J Ley (additional)

References 66 Referenced 125

10.1016/S1074-7613(00)80550-6 / Immunity / Granzyme B directly and efficiently cleaves several downstream caspase substrates by Andrade (1998)
10.1073/pnas.94.17.9285 / Proc. Natl. Acad. Sci. USA / Recombinant human granzyme A binds to two putative HLA-associated proteins and cleaves one of them by Beresford (1997)
10.1128/MCB.18.11.6387 / Mol. Cell. Biol / Selective regulation of apoptosis by Bird (1998)
10.1084/jem.183.2.657 / J. Exp. Med / Cytotoxic T cells deficient in both functional fas ligand and perforin show residual cytotolytic activity yet lose their capacity to induce lethal acute graft-versus-host disease by Braun (1996)
10.1038/377446a0 / Nature / Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B by Darmon (1995)
10.1074/jbc.271.36.21709 / J. Biol. Chem / Cleavage of CPP32 by granzyme B represents a critical role for granzyme B in the induction of target cell DNA fragmentation by Darmon (1996)
10.1038/40901 / Nature / X-linked IAP is a direct inhibitor of cell-death proteases by Deveraux (1997)
10.1084/jem.170.4.1451 / J. Exp. Med / Purified perforin induces target cell lysis but not DNA fragmentation by Duke (1989)
10.1002/j.1460-2075.1995.tb00097.x / EMBO J / Granzyme A-deficient mice retain potent cell-mediated cytotoxicity by Ebnet (1995)
10.1038/380723a0 / Nature / Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis by Enari (1996)
10.1038/34112 / Nature / A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD by Enari (1998)
10.1016/S0167-5699(97)01184-5 / Immunol. Today / Lymphocyte granule-mediated apoptosis by Froelich (1998)
10.1182/blood.V87.4.1232.bloodjournal8741232 / Blood / The role of granzyme B in murine models of acute graft-versus-host disease and graft rejection by Graubert (1996)
10.1172/JCI119606 / J. Clin. Invest / Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation by Graubert (1997)
10.1182/blood.V89.1.108 / Blood / Identification of a serpin specifically expressed in multipotent and bipotent hematopoietic progenitor cells and in activated T cells by Hampson (1997)
10.1074/jbc.273.42.27364 / J. Biol. Chem / Definition and redesign of the extended substrate specificity of granzyme B by Harris (1998)
10.1073/pnas.93.24.13786 / Proc. Natl. Acad. Sci. USA / Inhibition of interleukin 1β-converting enzyme-mediated apoptosis of mammalian cells by baculovirus IAP by Hawkins (1996)
10.1016/0092-8674(95)90150-7 / Cell / Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death by Hay (1995)
10.1016/1074-7613(94)90063-9 / Immunity / Lymphocyte-mediated cytotoxicity by Henkart (1994)
10.1016/0092-8674(94)90376-X / Cell / Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells by Heusel (1994)
10.4049/jimmunol.147.4.1360 / J. Immunol / The function of lymphocyte proteases. Inhibition and restoration of granule-mediated lysis with isocoumarin serine protease inhibitors by Hudig (1991)
10.1038/40657 / Nature / Inhibition of death receptor signals by cellular FLIP by Irmler (1997)
10.1074/jbc.271.48.30781 / J. Biol. Chem / Nuclear transport of granzyme B (Fragmentin-2) by Jans (1996)
10.1038/369031a0 / Nature / Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice by Kagi (1994)
10.1126/science.7518614 / Science / Fas involvement in calcium-independent T cell-mediated cytotoxicity by Kagi (1994)
10.1016/1074-7613(94)90066-3 / Immunity / Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes by Kojima (1994)
10.1016/S0092-8674(00)80197-X / Cell / DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis by Liu (1997)
10.1038/370650a0 / Nature / Cytolytic T-cell cytotoxicity is mediated through perforin and fas lytic pathways by Lowin (1994)
10.1002/j.1460-2075.1996.tb00598.x / EMBO J / The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism by Martin (1996)
10.1016/0092-8674(87)90544-7 / Cell / A family of serine esterases in lytic granules of cytolytic T lymphocytes by Masson (1987)
10.1073/pnas.93.12.5783 / Proc. Natl. Acad. Sci. USA / Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia by Mullbacher (1996)
10.1084/jem.181.3.1037 / J. Exp. Med / Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia most cell tumors also expressing cytolysin/perforin by Nakajima (1995)
10.1021/bi00222a027 / Biochemistry / Human and murine cytotoxic T lymphocyte serine proteases by Odake (1991)
10.1038/314743a0 / Nature / A novel serine esterase expressed by cytotoxic T lymphocytes by Pasternak (1985)
10.1073/pnas.93.23.13090 / Proc. Natl. Acad. Sci. USA / Long range disruption of gene expression by a selectable marker cassette by Pham (1996)
10.1074/jbc.273.3.1629 / J. Biol. Chem / Production of fully active recombinant murine granzyme B in yeast by Pham (1998)
10.1182/blood.V92.3.1044 / Blood / Entry and trafficking of granzyme B in target cells during granzyme B-perforin-mediated apoptosis by Pinkoski (1998)
10.1016/S0021-9258(18)52407-8 / J. Biol. Chem / Human cytotoxic lymphocyte granzyme B by Poe (1991)
10.1074/jbc.270.18.10377 / J. Biol. Chem / Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A by Quan (1995)
10.1073/pnas.93.5.1972 / Proc. Natl. Acad. Sci. USA / Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B by Quan (1996)
10.1016/0092-8674(92)90223-Y / Cell / Viral inhibition of inflammation by Ray (1992)
10.1016/0092-8674(95)90149-3 / Cell / The TNFR2-TRAF signaling complex contains two novel proteins related to baculovirual inhibitor of apoptosis proteins by Rothe (1995)
10.1084/jem.177.1.195 / J. Exp. Med / Fas involvement in calcium-independent T cell-mediated cytotoxicity by Rouvier (1993)
10.1016/S1074-7613(00)80427-6 / Immunity / Target cell lysis by CTL granule exocytosis is independent of ICE/Ced-3 family proteases by Sarin (1997)
10.4049/jimmunol.142.6.1847 / J. Immunol / Effector cell expression of NK1.1, a murine natural killer cell-specific molecule, and ability of mice to reject bone marrow allografts by Sentman (1989)
10.1084/jem.175.2.553 / J. Exp. Med / A natural killer cell granule protein that induces DNA fragmentation and apoptosis by Shi (1992)
10.1084/jem.176.6.1521 / J. Exp. Med / Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions by Shi (1992)
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10.1016/0092-8674(92)90359-K / Cell / Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A by Shiver (1992)
10.1073/pnas.92.12.5679 / Proc. Natl. Acad. Sci. USA / Natural killer and lymphokine-activated-killer cells require granzyme B for the rapid induction of DNA fragmentation and apoptosis in susceptible target cells by Shresta (1995)
10.1074/jbc.272.32.20236 / J. Biol Chem / Residual cytotoxicity and granzyme K expression in granzyme A-deficient cytotoxic lymphocytes by Shresta (1997)
10.1182/blood.V89.11.4085 / Blood / Mechanisms responsible for granzyme B-independent cytotoxicity by Shresta (1997)
10.1016/S0952-7915(98)80227-6 / Curr. Opin. Immunol / How do cytotoxic lymphocytes kill their targets? by Shresta (1998)
10.1128/JVI.69.6.3538-3541.1995 / J. Virol / Specific inhibition of granzyme B by parainfluenza virus type 3 by Sieg (1995)
10.1084/jem.186.10.1781 / J. Exp. Med / In vitro- and ex-vivo-derived cytolytic leukocytes from granzyme AxB double knockout mice are defective in granule-mediated apoptosis but not lysis of target cells by Simon (1997)
10.1128/JVI.72.1.1-9.1998 / J. Virol / The relative role of lymphocyte granule exocytosis versus death receptor-mediated cytotoxicity in viral pathophysiology by Smyth (1998)
10.1084/jem.163.4.998 / J. Exp. Med / Properties of purified T cell subsets. II. In vivo responses to class I vs. class II H-2 differences by Sprent (1986)
10.1074/jbc.271.44.27802 / J. Biol. Chem / A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes by Sun (1996)
10.1084/jem.186.8.1323 / J. Exp. Med / Granule-mediated killing by Talanian (1997)
10.1074/jbc.270.39.22705 / J. Biol. Chem / CrmA, a poxvirus-encoded serpin, inhibits cytotoxic T-lymphocyte-mediated apoptosis by Tewari (1995)
10.1074/jbc.272.29.17907 / J. Biol. Chem / A combinatorial approach defines specificities of members of the caspase family and granzyme B by Thornberry (1997)
10.1093/emboj/16.24.7287 / EMBO J / Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain by Uellner (1997)
10.1073/pnas.91.23.10854 / Proc. Natl. Acad. Sci / Immune function in mice lacking the perforin gene by Walsh (1994)
10.1006/bbrc.1998.8102 / Biochem. Biophys. Res. Commun / Expression and purification of enzymatically active recombinant granzyme B in a baculovirus system by Xia (1998)
10.1038/377248a0 / Nature / Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein by Xue (1995)
10.1074/jbc.272.12.7797 / J. Biol. Chem / Target protease specificity of the viral serpin CrmA by Zhou (1997)

Dates

Type	When
Created	21 years, 2 months ago (June 17, 2004, 7:28 a.m.)
Deposited	1 year, 7 months ago (Jan. 13, 2024, 12:27 p.m.)
Indexed	2 months ago (July 2, 2025, 11:58 a.m.)
Issued	26 years, 4 months ago (May 1, 1999)
Published	26 years, 4 months ago (May 1, 1999)
Published Print	26 years, 4 months ago (May 1, 1999)

Funders 0

None

BibTeX

@article{Shresta_1999, title={Granzyme A Initiates an Alternative Pathway for Granule-Mediated Apoptosis}, volume={10}, ISSN={1074-7613}, url={http://dx.doi.org/10.1016/s1074-7613(00)80059-x}, DOI={10.1016/s1074-7613(00)80059-x}, number={5}, journal={Immunity}, publisher={Elsevier BV}, author={Shresta, Sujan and Graubert, Timothy A and Thomas, Dori A and Raptis, Sofia Z and Ley, Timothy J}, year={1999}, month=may, pages={595–605} }

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      "author": "Braun",
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      "article-title": "Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice",
      "volume": "369",
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      "article-title": "Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes",
      "volume": "1",
      "author": "Kojima",
      "year": "1994",
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      "volume": "89",
      "author": "Liu",
      "year": "1997",
      "journal-title": "Cell"
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      "first-page": "650",
      "DOI": "10.1038/370650a0",
      "article-title": "Cytolytic T-cell cytotoxicity is mediated through perforin and fas lytic pathways",
      "volume": "370",
      "author": "Lowin",
      "year": "1994",
      "journal-title": "Nature"
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    {
      "key": "10.1016/S1074-7613(00)80059-X_BIB29",
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      "first-page": "2407",
      "DOI": "10.1002/j.1460-2075.1996.tb00598.x",
      "article-title": "The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism",
      "volume": "15",
      "author": "Martin",
      "year": "1996",
      "journal-title": "EMBO J"
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      "first-page": "679",
      "DOI": "10.1016/0092-8674(87)90544-7",
      "article-title": "A family of serine esterases in lytic granules of cytolytic T lymphocytes",
      "volume": "49",
      "author": "Masson",
      "year": "1987",
      "journal-title": "Cell"
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    {
      "key": "10.1016/S1074-7613(00)80059-X_BIB31",
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      "first-page": "5783",
      "DOI": "10.1073/pnas.93.12.5783",
      "article-title": "Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia",
      "volume": "93",
      "author": "Mullbacher",
      "year": "1996",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S1074-7613(00)80059-X_BIB32",
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      "first-page": "1037",
      "DOI": "10.1084/jem.181.3.1037",
      "article-title": "Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia most cell tumors also expressing cytolysin/perforin",
      "volume": "181",
      "author": "Nakajima",
      "year": "1995",
      "journal-title": "J. Exp. Med"
    },
    {
      "key": "10.1016/S1074-7613(00)80059-X_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "2217",
      "DOI": "10.1021/bi00222a027",
      "article-title": "Human and murine cytotoxic T lymphocyte serine proteases",
      "volume": "30",
      "author": "Odake",
      "year": "1991",
      "journal-title": "Biochemistry"
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    {
      "key": "10.1016/S1074-7613(00)80059-X_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "743",
      "DOI": "10.1038/314743a0",
      "article-title": "A novel serine esterase expressed by cytotoxic T lymphocytes",
      "volume": "314",
      "author": "Pasternak",
      "year": "1985",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S1074-7613(00)80059-X_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "13090",
      "DOI": "10.1073/pnas.93.23.13090",
      "article-title": "Long range disruption of gene expression by a selectable marker cassette",
      "volume": "93",
      "author": "Pham",
      "year": "1996",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S1074-7613(00)80059-X_BIB36",
      "doi-asserted-by": "crossref",
      "first-page": "1629",
      "DOI": "10.1074/jbc.273.3.1629",
      "article-title": "Production of fully active recombinant murine granzyme B in yeast",
      "volume": "273",
      "author": "Pham",
      "year": "1998",
      "journal-title": "J. Biol. Chem"
    },
    {
      "key": "10.1016/S1074-7613(00)80059-X_BIB37",
      "doi-asserted-by": "crossref",
      "first-page": "1044",
      "DOI": "10.1182/blood.V92.3.1044",
      "article-title": "Entry and trafficking of granzyme B in target cells during granzyme B-perforin-mediated apoptosis",
      "volume": "92",
      "author": "Pinkoski",
      "year": "1998",
      "journal-title": "Blood"
    },
    {
      "key": "10.1016/S1074-7613(00)80059-X_BIB38",
      "doi-asserted-by": "crossref",
      "first-page": "98",
      "DOI": "10.1016/S0021-9258(18)52407-8",
      "article-title": "Human cytotoxic lymphocyte granzyme B",
      "volume": "266",
      "author": "Poe",
      "year": "1991",
      "journal-title": "J. Biol. Chem"
    },
    {
      "key": "10.1016/S1074-7613(00)80059-X_BIB39",
      "doi-asserted-by": "crossref",
      "first-page": "10377",
      "DOI": "10.1074/jbc.270.18.10377",
      "article-title": "Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A",
      "volume": "270",
      "author": "Quan",
      "year": "1995",
      "journal-title": "J. Biol. Chem"
    },
    {
      "key": "10.1016/S1074-7613(00)80059-X_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "1972",
      "DOI": "10.1073/pnas.93.5.1972",
      "article-title": "Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B",
      "volume": "93",
      "author": "Quan",
      "year": "1996",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S1074-7613(00)80059-X_BIB41",
      "doi-asserted-by": "crossref",
      "first-page": "597",
      "DOI": "10.1016/0092-8674(92)90223-Y",
      "article-title": "Viral inhibition of inflammation",
      "volume": "69",
      "author": "Ray",
      "year": "1992",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S1074-7613(00)80059-X_BIB42",
      "doi-asserted-by": "crossref",
      "first-page": "1243",
      "DOI": "10.1016/0092-8674(95)90149-3",
      "article-title": "The TNFR2-TRAF signaling complex contains two novel proteins related to baculovirual inhibitor of apoptosis proteins",
      "volume": "83",
      "author": "Rothe",
      "year": "1995",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S1074-7613(00)80059-X_BIB43",
      "doi-asserted-by": "crossref",
      "first-page": "195",
      "DOI": "10.1084/jem.177.1.195",
      "article-title": "Fas involvement in calcium-independent T cell-mediated cytotoxicity",
      "volume": "177",
      "author": "Rouvier",
      "year": "1993",
      "journal-title": "J. Exp. Med"
    },
    {
      "key": "10.1016/S1074-7613(00)80059-X_BIB44",
      "doi-asserted-by": "crossref",
      "first-page": "209",
      "DOI": "10.1016/S1074-7613(00)80427-6",
      "article-title": "Target cell lysis by CTL granule exocytosis is independent of ICE/Ced-3 family proteases",
      "volume": "6",
      "author": "Sarin",
      "year": "1997",
      "journal-title": "Immunity"
    },
    {
      "key": "10.1016/S1074-7613(00)80059-X_BIB45",
      "doi-asserted-by": "crossref",
      "first-page": "1847",
      "DOI": "10.4049/jimmunol.142.6.1847",
      "article-title": "Effector cell expression of NK1.1, a murine natural killer cell-specific molecule, and ability of mice to reject bone marrow allografts",
      "volume": "142",
      "author": "Sentman",
      "year": "1989",
      "journal-title": "J. Immunol"
    },
    {
      "key": "10.1016/S1074-7613(00)80059-X_BIB46",
      "doi-asserted-by": "crossref",
      "first-page": "553",
      "DOI": "10.1084/jem.175.2.553",
      "article-title": "A natural killer cell granule protein that induces DNA fragmentation and apoptosis",
      "volume": "175",
      "author": "Shi",
      "year": "1992",
      "journal-title": "J. Exp. Med"
    },
    {
      "key": "10.1016/S1074-7613(00)80059-X_BIB47",
      "doi-asserted-by": "crossref",
      "first-page": "1521",
      "DOI": "10.1084/jem.176.6.1521",
      "article-title": "Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions",
      "volume": "176",
      "author": "Shi",
      "year": "1992",
      "journal-title": "J. Exp. Med"
    },
    {
      "key": "10.1016/S1074-7613(00)80059-X_BIB48",
      "first-page": "855",
      "article-title": "Granzyme B autonomously crosses the cell membrane and perforin initiates apoptosis and granzyme B nuclear localization",
      "volume": "195",
      "author": "Shi",
      "year": "1996",
      "journal-title": "J. Exp. Med"
    },
    {
      "key": "10.1016/S1074-7613(00)80059-X_BIB49",
      "doi-asserted-by": "crossref",
      "first-page": "315",
      "DOI": "10.1016/0092-8674(92)90359-K",
      "article-title": "Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A",
      "volume": "71",
      "author": "Shiver",
      "year": "1992",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S1074-7613(00)80059-X_BIB50",
      "doi-asserted-by": "crossref",
      "first-page": "5679",
      "DOI": "10.1073/pnas.92.12.5679",
      "article-title": "Natural killer and lymphokine-activated-killer cells require granzyme B for the rapid induction of DNA fragmentation and apoptosis in susceptible target cells",
      "volume": "92",
      "author": "Shresta",
      "year": "1995",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S1074-7613(00)80059-X_BIB51",
      "doi-asserted-by": "crossref",
      "first-page": "20236",
      "DOI": "10.1074/jbc.272.32.20236",
      "article-title": "Residual cytotoxicity and granzyme K expression in granzyme A-deficient cytotoxic lymphocytes",
      "volume": "272",
      "author": "Shresta",
      "year": "1997",
      "journal-title": "J. Biol Chem"
    },
    {
      "key": "10.1016/S1074-7613(00)80059-X_BIB52",
      "doi-asserted-by": "crossref",
      "first-page": "4085",
      "DOI": "10.1182/blood.V89.11.4085",
      "article-title": "Mechanisms responsible for granzyme B-independent cytotoxicity",
      "volume": "89",
      "author": "Shresta",
      "year": "1997",
      "journal-title": "Blood"
    },
    {
      "key": "10.1016/S1074-7613(00)80059-X_BIB53",
      "doi-asserted-by": "crossref",
      "first-page": "581",
      "DOI": "10.1016/S0952-7915(98)80227-6",
      "article-title": "How do cytotoxic lymphocytes kill their targets?",
      "volume": "10",
      "author": "Shresta",
      "year": "1998",
      "journal-title": "Curr. Opin. Immunol"
    },
    {
      "key": "10.1016/S1074-7613(00)80059-X_BIB54",
      "doi-asserted-by": "crossref",
      "first-page": "3538",
      "DOI": "10.1128/JVI.69.6.3538-3541.1995",
      "article-title": "Specific inhibition of granzyme B by parainfluenza virus type 3",
      "volume": "69",
      "author": "Sieg",
      "year": "1995",
      "journal-title": "J. Virol"
    },
    {
      "key": "10.1016/S1074-7613(00)80059-X_BIB55",
      "doi-asserted-by": "crossref",
      "first-page": "1781",
      "DOI": "10.1084/jem.186.10.1781",
      "article-title": "In vitro- and ex-vivo-derived cytolytic leukocytes from granzyme AxB double knockout mice are defective in granule-mediated apoptosis but not lysis of target cells",
      "volume": "186",
      "author": "Simon",
      "year": "1997",
      "journal-title": "J. Exp. Med"
    },
    {
      "key": "10.1016/S1074-7613(00)80059-X_BIB56",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1128/JVI.72.1.1-9.1998",
      "article-title": "The relative role of lymphocyte granule exocytosis versus death receptor-mediated cytotoxicity in viral pathophysiology",
      "volume": "72",
      "author": "Smyth",
      "year": "1998",
      "journal-title": "J. Virol"
    },
    {
      "key": "10.1016/S1074-7613(00)80059-X_BIB57",
      "doi-asserted-by": "crossref",
      "first-page": "998",
      "DOI": "10.1084/jem.163.4.998",
      "article-title": "Properties of purified T cell subsets. II. In vivo responses to class I vs. class II H-2 differences",
      "volume": "163",
      "author": "Sprent",
      "year": "1986",
      "journal-title": "J. Exp. Med"
    },
    {
      "key": "10.1016/S1074-7613(00)80059-X_BIB58",
      "doi-asserted-by": "crossref",
      "first-page": "27802",
      "DOI": "10.1074/jbc.271.44.27802",
      "article-title": "A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes",
      "volume": "271",
      "author": "Sun",
      "year": "1996",
      "journal-title": "J. Biol. Chem"
    },
    {
      "key": "10.1016/S1074-7613(00)80059-X_BIB59",
      "doi-asserted-by": "crossref",
      "first-page": "1323",
      "DOI": "10.1084/jem.186.8.1323",
      "article-title": "Granule-mediated killing",
      "volume": "186",
      "author": "Talanian",
      "year": "1997",
      "journal-title": "J. Exp. Med"
    },
    {
      "key": "10.1016/S1074-7613(00)80059-X_BIB60",
      "doi-asserted-by": "crossref",
      "first-page": "22705",
      "DOI": "10.1074/jbc.270.39.22705",
      "article-title": "CrmA, a poxvirus-encoded serpin, inhibits cytotoxic T-lymphocyte-mediated apoptosis",
      "volume": "270",
      "author": "Tewari",
      "year": "1995",
      "journal-title": "J. Biol. Chem"
    },
    {
      "key": "10.1016/S1074-7613(00)80059-X_BIB61",
      "doi-asserted-by": "crossref",
      "first-page": "17907",
      "DOI": "10.1074/jbc.272.29.17907",
      "article-title": "A combinatorial approach defines specificities of members of the caspase family and granzyme B",
      "volume": "272",
      "author": "Thornberry",
      "year": "1997",
      "journal-title": "J. Biol. Chem"
    },
    {
      "key": "10.1016/S1074-7613(00)80059-X_BIB62",
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      "first-page": "7287",
      "DOI": "10.1093/emboj/16.24.7287",
      "article-title": "Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain",
      "volume": "16",
      "author": "Uellner",
      "year": "1997",
      "journal-title": "EMBO J"
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      "DOI": "10.1073/pnas.91.23.10854",
      "article-title": "Immune function in mice lacking the perforin gene",
      "volume": "91",
      "author": "Walsh",
      "year": "1994",
      "journal-title": "Proc. Natl. Acad. Sci"
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      "first-page": "384",
      "DOI": "10.1006/bbrc.1998.8102",
      "article-title": "Expression and purification of enzymatically active recombinant granzyme B in a baculovirus system",
      "volume": "243",
      "author": "Xia",
      "year": "1998",
      "journal-title": "Biochem. Biophys. Res. Commun"
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      "DOI": "10.1038/377248a0",
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      "volume": "377",
      "author": "Xue",
      "year": "1995",
      "journal-title": "Nature"
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      "article-title": "Target protease specificity of the viral serpin CrmA",
      "volume": "272",
      "author": "Zhou",
      "year": "1997",
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