DOI: 10.1016/s1074-7613(00)00045-5. CD40 Triggering of Heterodimeric IL-12 p70 Production by Dendritic Cells In Vivo Requires a Microbial Priming Signal

CD40 Triggering of Heterodimeric IL-12 p70 Production by Dendritic Cells In Vivo Requires a Microbial Priming Signal

10.1016/s1074-7613(00)00045-5

Crossref journal-article

Elsevier BV

Immunity (78)

Bibliography

Schulz, O., Edwards, A. D., Schito, M., Aliberti, J., Manickasingham, S., Sher, A., & Reis e Sousa, C. (2000). CD40 Triggering of Heterodimeric IL-12 p70 Production by Dendritic Cells In Vivo Requires a Microbial Priming Signal. Immunity, 13(4), 453â462.

Authors 7

Oliver Schulz (first)
Alexander D Edwards (additional)
Marco Schito (additional)
Julio Aliberti (additional)
Shivanthi Manickasingham (additional)
Alan Sher (additional)
Caetano Reis e Sousa (additional)

References 43 Referenced 443

10.1084/jem.189.1.169 / J. Exp. Med. / DNA vaccination by Akbari (1999)
10.1182/blood.V93.2.590 / Blood / Definition of dendritic cell subpopulations present in the spleen, Peyer's patches, lymph nodes, and skin of the mouse by Anjuère (1999)
10.1146/annurev.iy.12.040194.004313 / Annu. Rev. Immunol. / The CD40 antigen and its ligand by Banchereau (1994)
10.1146/annurev.immunol.18.1.767 / Annu. Rev. Immunol. / Immunobiology of dendritic cells by Banchereau (2000)
10.1002/eji.1830241026 / Eur. J. Immunol. / Differential expression of mRNA encoding interleukin-12 p35 and p40 subunits in situ by Bette (1994)
10.1084/jem.184.2.747 / J. Exp. Med. / Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity by Cella (1996)
10.1084/jem.176.5.1387 / J. Exp. Med. / Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells by D'Andrea (1992)
10.1084/jem.184.4.1413 / J. Exp. Med. / Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo by De Smedt (1996)
10.1038/10495 / Nat. Med. / CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy by Diehl (1999)
10.1126/science.272.5258.50 / Science / The instructive role of innate immunity in the acquired immune response by Fearon (1996)
10.1038/5505 / Nat. Med. / CD40 antibody evokes a cytotoxic T-cell response that eradicates lymphoma and bypasses T-cell help by French (1999)
10.1146/annurev.immunol.16.1.495 / Annu. Rev. Immunol. / The interleukin-12/interleukin-12-receptor system by Gately (1998)
10.1146/annurev.immunol.16.1.111 / Annu. Rev. Immunol. / CD40 and CD154 in cell-mediated immunity by Grewal (1998)
10.1016/S1074-7613(00)80614-7 / Immunity / IL-12 acts directly on DC to promote nuclear localization of NF-kappaB and primes DC for IL-12 production by Grohmann (1998)
10.1128/IAI.64.6.2010-2018.1996 / Infect. Immun. / Biochemical characterization and protein kinase C dependency of monokine-inducing activities of Toxoplasma gondii by Grunvald (1996)
10.1002/eji.1830240817 / Eur. J. Immunol. / Properties of mouse CD40 by Hasbold (1994)
10.1182/blood.V90.5.1920 / Blood / Human dendritic cells require exogenous interleukin-12-inducing factors to direct the development of naive T-helper cells toward the Th1 phenotype by Hilkens (1997)
10.1084/jem.180.5.1849 / J. Exp. Med. / The tissue distribution of the B7–2 costimulator in mice by Inaba (1994)
10.1101/SQB.1989.054.01.003 / Cold Spring Harb. Symp. Quant. Biol. / Approaching the asymptote? Evolution and revolution in immunology by Janeway (1989)
10.4049/jimmunol.162.5.2562 / J. Immunol. / TRANCE, a TNF family member, is differentially expressed on T cell subsets and induces cytokine production in dendritic cells by Josien (1999)
10.1016/S0167-5699(99)01547-9 / Immunol. Today / T-cell priming by type-1 and type-2 polarized dendritic cells by Kalinski (1999)
10.4049/jimmunol.156.10.3932 / J. Immunol. / Induction of IL-12 p40 messenger RNA expression and IL-12 production of macrophages via CD40–CD40 ligand interaction by Kato (1996)
10.1084/jem.184.2.741 / J. Exp. Med. / High level IL-12 production by murine dendritic cells by Koch (1996)
10.1038/374546a0 / Nature / CpG motifs in bacterial DNA trigger direct B-cell activation by Krieg (1995)
10.4049/jimmunol.154.10.5071 / J. Immunol. / Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells by Macatonia (1995)
{'key': '10.1016/S1074-7613(00)00045-5_BIB26', 'article-title': 'In vivo regulation of antigen presentation by microbial and T cell-derived stimuli', 'volume': 'in press', 'author': 'Manickasingham', 'year': '2000', 'journal-title': 'J. Immunol.'} / J. Immunol. / In vivo regulation of antigen presentation by microbial and T cell-derived stimuli by Manickasingham (2000)
10.1126/science.2125367 / Science / Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo by Murphy (1990)
10.1084/jem.186.11.1819 / J. Exp. Med. / In vivo microbial stimulation induces rapid CD40L-independent production of IL-12 by dendritic cells and their re-distribution to T cell areas by Reis e Sousa (1997)
10.1016/S1074-7613(00)80138-7 / Immunity / Paralysis of dendritic cell IL-12 production by microbial products prevents infection-induced immunopathology by Reis e Sousa (1999)
10.1016/S0952-7915(99)80066-1 / Curr. Opin. Immunol. / The role of dendritic cells in the induction and regulation of immunity to microbial infection by Reis e Sousa (1999)
10.1016/S1074-7613(00)80258-7 / Immunity / The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching by Rolink (1996)
10.1002/(SICI)1521-4141(199911)29:11<3762::AID-IMMU3762>3.0.CO;2-F / Eur. J. Immunol. / CTL priming by CD8(+) and CD8(-) dendritic cells in vivo by Ruedl (1999)
{'key': '10.1016/S1074-7613(00)00045-5_BIB33', 'first-page': '65', 'article-title': 'Ignition of the type 1 response to intracellular infection by dendritic cell-derived IL-12', 'volume': '9', 'author': 'Sher', 'year': '1998', 'journal-title': 'Eur. Cytokine Netw.'} / Eur. Cytokine Netw. / Ignition of the type 1 response to intracellular infection by dendritic cell-derived IL-12 by Sher (1998)
10.4049/jimmunol.156.3.1207 / J. Immunol. / Regulation of bioactive IL-12 production in lipopolysaccharide- stimulated human monocytes is determined by the expression of the p35 subunit by Snijders (1996)
10.1093/intimm/10.11.1593 / Int. Immunol. / High-level IL-12 production by human dendritic cells requires two signals by Snijders (1998)
10.1038/10503 / Nat. Med. / Conversion of tumor-specific CD4+ T-cell tolerance to T-cell priming through in vivo ligation of CD40 by Sotomayor (1999)
10.1084/jem.188.11.2019 / J. Exp. Med. / Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Th1 immunity by Stumbles (1998)
10.1016/S0065-2776(08)60387-9 / Adv. Immunol. / Interleukin-12 by Trinchieri (1998)
10.1111/j.1365-2567.1996.tb00018.x / Immunology / Properties of mouse CD40 by Van Den Berg (1996)
10.4049/jimmunol.164.9.4507 / J. Immunol. / Development of Th1-inducing capacity in myeloid dendritic cells requires environmental instruction by Vieira (2000)
10.4049/jimmunol.164.6.2978 / J. Immunol. / CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleen by Vremec (2000)
10.1002/eji.1830250307 / Eur. J. Immunol. / Interleukin-12 is required for interferon-γ production and lethality in lipopolysaccharide-induced shock in mice by Wysocka (1995)
10.4049/jimmunol.162.11.6433 / J. Immunol. / Effective stimulation for IL-12 p35 mRNA accumulation and bioactive IL- 12 production of antigen-presenting cells interacted with Th cells by Yamane (1999)

Dates

Type	When
Created	21 years, 4 months ago (April 15, 2004, 5:36 a.m.)
Deposited	2 years, 3 months ago (April 28, 2023, 4:02 a.m.)
Indexed	43 minutes ago (Aug. 26, 2025, 10:54 p.m.)
Issued	24 years, 10 months ago (Oct. 1, 2000)
Published	24 years, 10 months ago (Oct. 1, 2000)
Published Print	24 years, 10 months ago (Oct. 1, 2000)

Funders 0

None

BibTeX

@article{Schulz_2000, title={CD40 Triggering of Heterodimeric IL-12 p70 Production by Dendritic Cells In Vivo Requires a Microbial Priming Signal}, volume={13}, ISSN={1074-7613}, url={http://dx.doi.org/10.1016/s1074-7613(00)00045-5}, DOI={10.1016/s1074-7613(00)00045-5}, number={4}, journal={Immunity}, publisher={Elsevier BV}, author={Schulz, Oliver and Edwards, Alexander D and Schito, Marco and Aliberti, Julio and Manickasingham, Shivanthi and Sher, Alan and Reis e Sousa, Caetano}, year={2000}, month=oct, pages={453–462} }

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      "author": "Banchereau",
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      "author": "Bette",
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      "volume": "184",
      "author": "Cella",
      "year": "1996",
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      "article-title": "Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells",
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      "author": "D'Andrea",
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      "author": "Diehl",
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      "volume": "5",
      "author": "French",
      "year": "1999",
      "journal-title": "Nat. Med."
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      "doi-asserted-by": "crossref",
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      "author": "Grohmann",
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      "volume": "180",
      "author": "Inaba",
      "year": "1994",
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      "author": "Kalinski",
      "year": "1999",
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      "volume": "156",
      "author": "Kato",
      "year": "1996",
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      "author": "Koch",
      "year": "1996",
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      "first-page": "546",
      "DOI": "10.1038/374546a0",
      "article-title": "CpG motifs in bacterial DNA trigger direct B-cell activation",
      "volume": "374",
      "author": "Krieg",
      "year": "1995",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S1074-7613(00)00045-5_BIB25",
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      "volume": "154",
      "author": "Macatonia",
      "year": "1995",
      "journal-title": "J. Immunol."
    },
    {
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      "article-title": "In vivo regulation of antigen presentation by microbial and T cell-derived stimuli",
      "volume": "in press",
      "author": "Manickasingham",
      "year": "2000",
      "journal-title": "J. Immunol."
    },
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      "first-page": "1720",
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      "article-title": "Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo",
      "volume": "250",
      "author": "Murphy",
      "year": "1990",
      "journal-title": "Science"
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      "doi-asserted-by": "crossref",
      "first-page": "1819",
      "DOI": "10.1084/jem.186.11.1819",
      "article-title": "In vivo microbial stimulation induces rapid CD40L-independent production of IL-12 by dendritic cells and their re-distribution to T cell areas",
      "volume": "186",
      "author": "Reis e Sousa",
      "year": "1997",
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      "author": "Reis e Sousa",
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      "journal-title": "Immunity"
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      "article-title": "The role of dendritic cells in the induction and regulation of immunity to microbial infection",
      "volume": "11",
      "author": "Reis e Sousa",
      "year": "1999",
      "journal-title": "Curr. Opin. Immunol."
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      "article-title": "The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching",
      "volume": "5",
      "author": "Rolink",
      "year": "1996",
      "journal-title": "Immunity"
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      "article-title": "CTL priming by CD8(+) and CD8(-) dendritic cells in vivo",
      "volume": "29",
      "author": "Ruedl",
      "year": "1999",
      "journal-title": "Eur. J. Immunol."
    },
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      "first-page": "65",
      "article-title": "Ignition of the type 1 response to intracellular infection by dendritic cell-derived IL-12",
      "volume": "9",
      "author": "Sher",
      "year": "1998",
      "journal-title": "Eur. Cytokine Netw."
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      "DOI": "10.4049/jimmunol.156.3.1207",
      "article-title": "Regulation of bioactive IL-12 production in lipopolysaccharide- stimulated human monocytes is determined by the expression of the p35 subunit",
      "volume": "156",
      "author": "Snijders",
      "year": "1996",
      "journal-title": "J. Immunol."
    },
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      "first-page": "1593",
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      "article-title": "High-level IL-12 production by human dendritic cells requires two signals",
      "volume": "10",
      "author": "Snijders",
      "year": "1998",
      "journal-title": "Int. Immunol."
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      "DOI": "10.1038/10503",
      "article-title": "Conversion of tumor-specific CD4+ T-cell tolerance to T-cell priming through in vivo ligation of CD40",
      "volume": "5",
      "author": "Sotomayor",
      "year": "1999",
      "journal-title": "Nat. Med."
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      "doi-asserted-by": "crossref",
      "first-page": "2019",
      "DOI": "10.1084/jem.188.11.2019",
      "article-title": "Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Th1 immunity",
      "volume": "188",
      "author": "Stumbles",
      "year": "1998",
      "journal-title": "J. Exp. Med."
    },
    {
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      "first-page": "83",
      "DOI": "10.1016/S0065-2776(08)60387-9",
      "article-title": "Interleukin-12",
      "volume": "70",
      "author": "Trinchieri",
      "year": "1998",
      "journal-title": "Adv. Immunol."
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      "first-page": "294",
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      "article-title": "Properties of mouse CD40",
      "volume": "88",
      "author": "Van Den Berg",
      "year": "1996",
      "journal-title": "Immunology"
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      "article-title": "Development of Th1-inducing capacity in myeloid dendritic cells requires environmental instruction",
      "volume": "164",
      "author": "Vieira",
      "year": "2000",
      "journal-title": "J. Immunol."
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      "article-title": "CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleen",
      "volume": "164",
      "author": "Vremec",
      "year": "2000",
      "journal-title": "J. Immunol."
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      "article-title": "Interleukin-12 is required for interferon-\u03b3 production and lethality in lipopolysaccharide-induced shock in mice",
      "volume": "25",
      "author": "Wysocka",
      "year": "1995",
      "journal-title": "Eur. J. Immunol."
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      "article-title": "Effective stimulation for IL-12 p35 mRNA accumulation and bioactive IL- 12 production of antigen-presenting cells interacted with Th cells",
      "volume": "162",
      "author": "Yamane",
      "year": "1999",
      "journal-title": "J. Immunol."
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