DOI: 10.1016/s0969-2126(96)00091-3. Structure of unliganded HIV-1 reverse transcriptase at 2.7 å resolution: implications of conformational changes for polymerization and inhibition mechanisms

Structure of unliganded HIV-1 reverse transcriptase at 2.7 å resolution: implications of conformational changes for polymerization and inhibition mechanisms

10.1016/s0969-2126(96)00091-3

Crossref journal-article

Elsevier BV

Structure (78)

Bibliography

Hsiou, Y., Ding, J., Das, K., Clark, Jr, A., Hughes, S., & Arnold, E. (1996). Structure of unliganded HIV-1 reverse transcriptase at 2.7 Ã¥ resolution: implications of conformational changes for polymerization and inhibition mechanisms. Structure, 4(7), 853â860.

Authors 6

Y Hsiou (first)
J Ding (additional)
K Das (additional)
AD Clark, Jr (additional)
SH Hughes (additional)
E Arnold (additional)

References 32 Referenced 244

{'key': '10.1016/S0969-2126(96)00091-3_BIB1', 'series-title': 'Reverse Transcriptase', 'first-page': '205', 'article-title': 'Inhibitors of HIV reverse transcriptase as antiviral agents and drug resistance', 'author': 'Larder', 'year': '1993'} / Reverse Transcriptase / Inhibitors of HIV reverse transcriptase as antiviral agents and drug resistance by Larder (1993)
10.1006/jmbi.1994.1665 / J. Mol. Biol / Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase: implications for mechanisms of drug inhibition and resistance by Tantillo (1994)
10.1021/jm00014a001 / J. Med. Chem / Toward improved anti-HIV chemotherapy: Therapeutic strategies for intervention with HIV infections by De Clercq (1995)
{'key': '10.1016/S0969-2126(96)00091-3_BIB4', 'first-page': '29', 'article-title': 'Targeting HIV reverse transcriptase for anti-AIDS drug design', 'volume': '13', 'author': 'Arnold', 'year': '1996', 'journal-title': 'Drug Design and Discovery'} / Drug Design and Discovery / Targeting HIV reverse transcriptase for anti-AIDS drug design by Arnold (1996)
10.1126/science.1377403 / Science / Crystal structure at 3.5 å resolution of HIV-1 reverse transcriptase complexed with an inhibitor by Kohlstaedt (1992)
10.1073/pnas.91.9.3911 / Proc. Natl. Acad. Sci. USA / Structure of the binding site for non-nucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1 by Smerdon (1994)
10.1038/nsb0495-293 / Nat. Struct. Biol / High resolution structures of HIV-1 RT from four RT-inhibitor complexes by Ren (1995)
10.1016/S0969-2126(01)00168-X / Structure / Structure of HIV-1 reverse transcriptase in a complex with the non-nucleoside inhibitor α-APA R 95845 at 2.8 å resolution by Ding (1995)
10.1038/nsb0595-407 / Nat. Struct. Biol / Structure of HIV-1 RT/TIBO R 86183 reveals similarity in the binding of diverse non-nucleoside inhibitors by Ding (1995)
10.1016/S0969-2126(01)00226-X / Structure / The structure of HIV-1 reverse transcriptase complexed with 9-chloro-TIBO: lessons for inhibitor design by Ren (1995)
10.1073/pnas.90.13.6320 / Proc. Natl. Acad. Sci. USA / Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 å resolution shows bent DNA by Jacobo-Molina (1993)
10.1073/pnas.92.4.1222 / Proc. Natl. Acad. Sci. USA / The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1 by Rodgers (1995)
10.1038/nsb0495-303 / Nat. Struct. Biol / Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors by Esnouf (1995)
10.1016/S0969-2126(01)00223-4 / Structure / Mechanistic implications from the structure of a catalytic fragment of Moloney murine leukemia virus reverse transcriptase by Georgiadis (1995)
10.1016/S0969-2126(94)00087-5 / Structure / Comparison of three different crystal forms shows HIV-1 reverse transcriptase displays an internal swivel motion by Jäger (1994)
10.1126/science.7532321 / Science / Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors by Spence (1995)
10.1073/pnas.92.17.8046 / Proc. Natl. Acad. Sci. USA / Human immunodeficiency virus reverse transcriptase substrate-induced conformational changes and the mechanism of inhibition by non-nucleoside inhibitors by Rittinger (1995)
10.1073/pnas.88.4.1451 / Proc. Natl. Acad. Sci. USA / An antiviral target on reverse transcriptase of human immunodeficiency virus type 1 revealed by tetrahydroimidazo-[4,5,1-jk][1,4]benzodiazepinone-2(1H)-one and -thione derivatives by Debyser (1991)
10.1074/jbc.270.9.4861 / J. Biol. Chem / Nevirapine alters the cleavage specificity of ribonuclease H of human immunodeficiency virus 1 reverse transcriptase by Palaniappan (1995)
10.1128/JVI.66.2.1031-1039.1992 / J. Virol / Cassette mutagenesis of the reverse transcriptase of human immunodeficiency virus type 1 by Boyer (1992)
10.1128/JVI.66.12.7533-7537.1992 / J. Virol / Mutational analysis of the fingers domain of human immunodeficiency virus type-1 reverse transcriptase by Boyer (1992)
10.1006/jmbi.1994.1673 / J. Mol. Biol / Mutational analysis of the fingers and palm subdomains of human immunodeficiency virus type-1 (HIV-1) reverse transcriptase by Boyer (1994)
10.1073/pnas.93.1.34 / Proc. Natl. Acad. Sci. USA by Kleim (1996)
10.1016/0076-6879(95)62017-6 / Methods in Enzymology / Crystallization of human immunodeficiency virus type-1 reverse transcriptase with and without nucleic acid substrates, inhibitors and an antibody Fab fragment by Clark (1995)
10.1107/S0021889890005568 / J. Appl. Cryst / Mounting of crystals for macromolecular crystallography in a free-standing thin film by Teng (1990)
10.1016/S0969-2126(94)00116-2 / Structure / Cryocrystallography by Rodgers (1994)
{'key': '10.1016/S0969-2126(96)00091-3_BIB27', 'series-title': 'Proceeding of the CCP4 Study Weekend: Data Collection and Processing', 'first-page': '55', 'article-title': 'Oscillation Data Reduction Program', 'author': 'Otwinowski', 'year': '1993'} / Proceeding of the CCP4 Study Weekend: Data Collection and Processing / Oscillation Data Reduction Program by Otwinowski (1993)
{'key': '10.1016/S0969-2126(96)00091-3_BIB28', 'series-title': 'XDISPLAYF Program', 'author': 'Miner', 'year': '1993'} / XDISPLAYF Program by Miner (1993)
10.1107/S0907444994003112 / Acta Cryst. D / The CCP4 Suite: Programs for Protein Crystallography by Collaborative Computational Project No. 4 (1994)
{'key': '10.1016/S0969-2126(96)00091-3_BIB30', 'series-title': 'X-PLOR Manual Version 3.1: A system for X-ray crystallography and NMR', 'author': 'Brünger', 'year': '1993'} / X-PLOR Manual Version 3.1: A system for X-ray crystallography and NMR by Brünger (1993)
10.1107/S0108767390010224 / Acta Cryst. A / Improved methods for building protein models in electron density maps and the location of errors in these models by Jones (1991)
10.1016/0263-7855(87)80010-3 / J. Mol. Graphics / Ribbon models of macromolecules by Carson (1987)

Dates

Type	When
Created	21 years, 2 months ago (June 8, 2004, 2:49 p.m.)
Deposited	5 years, 4 months ago (April 2, 2020, 6:46 a.m.)
Indexed	1 month, 1 week ago (July 25, 2025, 6:47 a.m.)
Issued	29 years, 2 months ago (July 1, 1996)
Published	29 years, 2 months ago (July 1, 1996)
Published Print	29 years, 2 months ago (July 1, 1996)

Funders 0

None

BibTeX

@article{Hsiou_1996, Jr_Hughes_Arnold_1996, title={Structure of unliganded HIV-1 reverse transcriptase at 2.7 å resolution: implications of conformational changes for polymerization and inhibition mechanisms}, volume={4}, ISSN={0969-2126}, url={http://dx.doi.org/10.1016/s0969-2126(96)00091-3}, DOI={10.1016/s0969-2126(96)00091-3}, number={7}, journal={Structure}, publisher={Elsevier BV}, author={Hsiou, Y and Ding, J and Das, K and Clark, Jr, AD and Hughes, SH and Arnold, E}, year={1996}, month=jul, pages={853–860} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        25
      ]
    ],
    "date-time": "2025-07-25T10:47:36Z",
    "timestamp": 1753440456389
  },
  "reference-count": 32,
  "publisher": "Elsevier BV",
  "issue": "7",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1996,
            7,
            1
          ]
        ],
        "date-time": "1996-07-01T00:00:00Z",
        "timestamp": 836179200000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2013,
            7,
            17
          ]
        ],
        "date-time": "2013-07-17T00:00:00Z",
        "timestamp": 1374019200000
      },
      "content-version": "vor",
      "delay-in-days": 6225,
      "URL": "https://www.elsevier.com/open-access/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1996,
        7
      ]
    ]
  },
  "DOI": "10.1016/s0969-2126(96)00091-3",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2004,
        6,
        8
      ]
    ],
    "date-time": "2004-06-08T18:49:43Z",
    "timestamp": 1086720583000
  },
  "page": "853-860",
  "source": "Crossref",
  "is-referenced-by-count": 244,
  "title": "Structure of unliganded HIV-1 reverse transcriptase at 2.7 \u00e5 resolution: implications of conformational changes for polymerization and inhibition mechanisms",
  "prefix": "10.1016",
  "volume": "4",
  "author": [
    {
      "given": "Y",
      "family": "Hsiou",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "J",
      "family": "Ding",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "K",
      "family": "Das",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "AD",
      "family": "Clark, Jr",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "SH",
      "family": "Hughes",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "E",
      "family": "Arnold",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/S0969-2126(96)00091-3_BIB1",
      "series-title": "Reverse Transcriptase",
      "first-page": "205",
      "article-title": "Inhibitors of HIV reverse transcriptase as antiviral agents and drug resistance",
      "author": "Larder",
      "year": "1993"
    },
    {
      "key": "10.1016/S0969-2126(96)00091-3_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "369",
      "DOI": "10.1006/jmbi.1994.1665",
      "article-title": "Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase: implications for mechanisms of drug inhibition and resistance",
      "volume": "243",
      "author": "Tantillo",
      "year": "1994",
      "journal-title": "J. Mol. Biol"
    },
    {
      "key": "10.1016/S0969-2126(96)00091-3_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "2491",
      "DOI": "10.1021/jm00014a001",
      "article-title": "Toward improved anti-HIV chemotherapy: Therapeutic strategies for intervention with HIV infections",
      "volume": "38",
      "author": "De Clercq",
      "year": "1995",
      "journal-title": "J. Med. Chem"
    },
    {
      "key": "10.1016/S0969-2126(96)00091-3_BIB4",
      "first-page": "29",
      "article-title": "Targeting HIV reverse transcriptase for anti-AIDS drug design",
      "volume": "13",
      "author": "Arnold",
      "year": "1996",
      "journal-title": "Drug Design and Discovery"
    },
    {
      "key": "10.1016/S0969-2126(96)00091-3_BIB5",
      "doi-asserted-by": "crossref",
      "first-page": "1783",
      "DOI": "10.1126/science.1377403",
      "article-title": "Crystal structure at 3.5 \u00e5 resolution of HIV-1 reverse transcriptase complexed with an inhibitor",
      "volume": "256",
      "author": "Kohlstaedt",
      "year": "1992",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0969-2126(96)00091-3_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "3911",
      "DOI": "10.1073/pnas.91.9.3911",
      "article-title": "Structure of the binding site for non-nucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1",
      "volume": "91",
      "author": "Smerdon",
      "year": "1994",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0969-2126(96)00091-3_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "293",
      "DOI": "10.1038/nsb0495-293",
      "article-title": "High resolution structures of HIV-1 RT from four RT-inhibitor complexes",
      "volume": "2",
      "author": "Ren",
      "year": "1995",
      "journal-title": "Nat. Struct. Biol"
    },
    {
      "key": "10.1016/S0969-2126(96)00091-3_BIB8",
      "doi-asserted-by": "crossref",
      "first-page": "365",
      "DOI": "10.1016/S0969-2126(01)00168-X",
      "article-title": "Structure of HIV-1 reverse transcriptase in a complex with the non-nucleoside inhibitor \u03b1-APA R 95845 at 2.8 \u00e5 resolution",
      "volume": "3",
      "author": "Ding",
      "year": "1995",
      "journal-title": "Structure"
    },
    {
      "key": "10.1016/S0969-2126(96)00091-3_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "407",
      "DOI": "10.1038/nsb0595-407",
      "article-title": "Structure of HIV-1 RT/TIBO R 86183 reveals similarity in the binding of diverse non-nucleoside inhibitors",
      "volume": "2",
      "author": "Ding",
      "year": "1995",
      "journal-title": "Nat. Struct. Biol"
    },
    {
      "key": "10.1016/S0969-2126(96)00091-3_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "915",
      "DOI": "10.1016/S0969-2126(01)00226-X",
      "article-title": "The structure of HIV-1 reverse transcriptase complexed with 9-chloro-TIBO: lessons for inhibitor design",
      "volume": "3",
      "author": "Ren",
      "year": "1995",
      "journal-title": "Structure"
    },
    {
      "key": "10.1016/S0969-2126(96)00091-3_BIB11",
      "doi-asserted-by": "crossref",
      "first-page": "6320",
      "DOI": "10.1073/pnas.90.13.6320",
      "article-title": "Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 \u00e5 resolution shows bent DNA",
      "volume": "90",
      "author": "Jacobo-Molina",
      "year": "1993",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0969-2126(96)00091-3_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "1222",
      "DOI": "10.1073/pnas.92.4.1222",
      "article-title": "The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1",
      "volume": "92",
      "author": "Rodgers",
      "year": "1995",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0969-2126(96)00091-3_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "303",
      "DOI": "10.1038/nsb0495-303",
      "article-title": "Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors",
      "volume": "2",
      "author": "Esnouf",
      "year": "1995",
      "journal-title": "Nat. Struct. Biol"
    },
    {
      "key": "10.1016/S0969-2126(96)00091-3_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "879",
      "DOI": "10.1016/S0969-2126(01)00223-4",
      "article-title": "Mechanistic implications from the structure of a catalytic fragment of Moloney murine leukemia virus reverse transcriptase",
      "volume": "3",
      "author": "Georgiadis",
      "year": "1995",
      "journal-title": "Structure"
    },
    {
      "key": "10.1016/S0969-2126(96)00091-3_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "869",
      "DOI": "10.1016/S0969-2126(94)00087-5",
      "article-title": "Comparison of three different crystal forms shows HIV-1 reverse transcriptase displays an internal swivel motion",
      "volume": "2",
      "author": "J\u00e4ger",
      "year": "1994",
      "journal-title": "Structure"
    },
    {
      "key": "10.1016/S0969-2126(96)00091-3_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "988",
      "DOI": "10.1126/science.7532321",
      "article-title": "Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors",
      "volume": "267",
      "author": "Spence",
      "year": "1995",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0969-2126(96)00091-3_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "8046",
      "DOI": "10.1073/pnas.92.17.8046",
      "article-title": "Human immunodeficiency virus reverse transcriptase substrate-induced conformational changes and the mechanism of inhibition by non-nucleoside inhibitors",
      "volume": "92",
      "author": "Rittinger",
      "year": "1995",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0969-2126(96)00091-3_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "1451",
      "DOI": "10.1073/pnas.88.4.1451",
      "article-title": "An antiviral target on reverse transcriptase of human immunodeficiency virus type 1 revealed by tetrahydroimidazo-[4,5,1-jk][1,4]benzodiazepinone-2(1H)-one and -thione derivatives",
      "volume": "88",
      "author": "Debyser",
      "year": "1991",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0969-2126(96)00091-3_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "4861",
      "DOI": "10.1074/jbc.270.9.4861",
      "article-title": "Nevirapine alters the cleavage specificity of ribonuclease H of human immunodeficiency virus 1 reverse transcriptase",
      "volume": "270",
      "author": "Palaniappan",
      "year": "1995",
      "journal-title": "J. Biol. Chem"
    },
    {
      "key": "10.1016/S0969-2126(96)00091-3_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "1031",
      "DOI": "10.1128/JVI.66.2.1031-1039.1992",
      "article-title": "Cassette mutagenesis of the reverse transcriptase of human immunodeficiency virus type 1",
      "volume": "66",
      "author": "Boyer",
      "year": "1992",
      "journal-title": "J. Virol"
    },
    {
      "key": "10.1016/S0969-2126(96)00091-3_BIB21",
      "doi-asserted-by": "crossref",
      "first-page": "7533",
      "DOI": "10.1128/JVI.66.12.7533-7537.1992",
      "article-title": "Mutational analysis of the fingers domain of human immunodeficiency virus type-1 reverse transcriptase",
      "volume": "66",
      "author": "Boyer",
      "year": "1992",
      "journal-title": "J. Virol"
    },
    {
      "key": "10.1016/S0969-2126(96)00091-3_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "472",
      "DOI": "10.1006/jmbi.1994.1673",
      "article-title": "Mutational analysis of the fingers and palm subdomains of human immunodeficiency virus type-1 (HIV-1) reverse transcriptase",
      "volume": "243",
      "author": "Boyer",
      "year": "1994",
      "journal-title": "J. Mol. Biol"
    },
    {
      "key": "10.1016/S0969-2126(96)00091-3_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "34",
      "DOI": "10.1073/pnas.93.1.34",
      "volume": "93",
      "author": "Kleim",
      "year": "1996",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0969-2126(96)00091-3_BIB24",
      "series-title": "Methods in Enzymology",
      "doi-asserted-by": "crossref",
      "first-page": "171",
      "DOI": "10.1016/0076-6879(95)62017-6",
      "article-title": "Crystallization of human immunodeficiency virus type-1 reverse transcriptase with and without nucleic acid substrates, inhibitors and an antibody Fab fragment",
      "author": "Clark",
      "year": "1995"
    },
    {
      "key": "10.1016/S0969-2126(96)00091-3_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "387",
      "DOI": "10.1107/S0021889890005568",
      "article-title": "Mounting of crystals for macromolecular crystallography in a free-standing thin film",
      "volume": "24",
      "author": "Teng",
      "year": "1990",
      "journal-title": "J. Appl. Cryst"
    },
    {
      "key": "10.1016/S0969-2126(96)00091-3_BIB26",
      "doi-asserted-by": "crossref",
      "first-page": "1135",
      "DOI": "10.1016/S0969-2126(94)00116-2",
      "article-title": "Cryocrystallography",
      "volume": "2",
      "author": "Rodgers",
      "year": "1994",
      "journal-title": "Structure"
    },
    {
      "key": "10.1016/S0969-2126(96)00091-3_BIB27",
      "series-title": "Proceeding of the CCP4 Study Weekend: Data Collection and Processing",
      "first-page": "55",
      "article-title": "Oscillation Data Reduction Program",
      "author": "Otwinowski",
      "year": "1993"
    },
    {
      "key": "10.1016/S0969-2126(96)00091-3_BIB28",
      "series-title": "XDISPLAYF Program",
      "author": "Miner",
      "year": "1993"
    },
    {
      "key": "10.1016/S0969-2126(96)00091-3_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "760",
      "DOI": "10.1107/S0907444994003112",
      "article-title": "The CCP4 Suite: Programs for Protein Crystallography",
      "volume": "50",
      "author": "Collaborative Computational Project No. 4",
      "year": "1994",
      "journal-title": "Acta Cryst. D"
    },
    {
      "key": "10.1016/S0969-2126(96)00091-3_BIB30",
      "series-title": "X-PLOR Manual Version 3.1: A system for X-ray crystallography and NMR",
      "author": "Br\u00fcnger",
      "year": "1993"
    },
    {
      "key": "10.1016/S0969-2126(96)00091-3_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "110",
      "DOI": "10.1107/S0108767390010224",
      "article-title": "Improved methods for building protein models in electron density maps and the location of errors in these models",
      "volume": "47",
      "author": "Jones",
      "year": "1991",
      "journal-title": "Acta Cryst. A"
    },
    {
      "key": "10.1016/S0969-2126(96)00091-3_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "103",
      "DOI": "10.1016/0263-7855(87)80010-3",
      "article-title": "Ribbon models of macromolecules",
      "volume": "5",
      "author": "Carson",
      "year": "1987",
      "journal-title": "J. Mol. Graphics"
    }
  ],
  "container-title": "Structure",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0969212696000913?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0969212696000913?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2020,
        4,
        2
      ]
    ],
    "date-time": "2020-04-02T10:46:06Z",
    "timestamp": 1585824366000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0969212696000913"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1996,
        7
      ]
    ]
  },
  "references-count": 32,
  "journal-issue": {
    "issue": "7",
    "published-print": {
      "date-parts": [
        [
          1996,
          7
        ]
      ]
    }
  },
  "alternative-id": [
    "S0969212696000913"
  ],
  "URL": "http://dx.doi.org/10.1016/S0969-2126(96)00091-3",
  "relation": {},
  "ISSN": [
    "0969-2126"
  ],
  "subject": [],
  "container-title-short": "Structure",
  "published": {
    "date-parts": [
      [
        1996,
        7
      ]
    ]
  }
}