DOI: 10.1016/s0969-2126(01)00180-0. Two structures of the catalytic domain of phosphorylase kinase: an active protein kinase complexed with substrate analogue and product

Two structures of the catalytic domain of phosphorylase kinase: an active protein kinase complexed with substrate analogue and product

10.1016/s0969-2126(01)00180-0

Crossref journal-article

Elsevier BV

Structure (78)

Bibliography

Owen, D., Noble, M., Garman, E., Papageorigiou, A., & Johnson, L. (1995). Two structures of the catalytic domain of phosphorylase kinase: an active protein kinase complexed with substrate analogue and product. Structure, 3(5), 467â482.

Authors 5

DJ Owen (first)
MEM Noble (additional)
EF Garman (additional)
AC Papageorigiou (additional)
LN Johnson (additional)

References 65 Referenced 131

10.1146/annurev.bb.22.060193.001215 / Annu. Rev. Biophys. Biomol. Struct / The effects of phosphorylation on the structure and function of proteins by Johnson (1993)
10.1016/S0021-9258(19)52289-X / J. Biol. Chem / Conversion of phosphorylase β to phosphorylase α in muscle extracts by Fischer (1955)
10.1016/S0021-9258(18)69910-7 / J. Biol. Chem / Structure of the site phosphorylated in the phosphorylase β to α reaction by Fischer (1959)
10.1016/S0021-9258(19)34204-8 / J. Biol. Chem / An adenosine 3′,5′-monophosphate dependent protein kinase from rabbit muscle by Walsh (1968)
10.1016/S1874-6047(08)60435-7 / The Enzymes / Glycogen phosphorylase kinase by Pickett-Gies (1986)
10.1038/296613a0 / Nature / The role of protein phosphorylation in neuronal and hormonal control of cellular activity by Cohen (1982)
10.1016/S0021-9258(18)45294-5 / J. Biol. Chem / Inhibition of the catalytic subunit of phosphorylase kinase by its α/β subunits by Paudel (1987)
10.1073/pnas.85.24.9381 / Proc. Natl. Acad. Sci. USA / The α and β subunits of phosphorylase kinase are homologous: cDNA cloning and primary structure of the β subunit by Kilimann (1988)
10.1016/0014-5793(78)80772-8 / FEBS Lett / Identification of the Ca2+-dependent modulator protein as the fourth subunit of rabbit skeletal muscle phosphorylase kinase by Cohen (1978)
10.1021/bi00313a027 / Biochemistry / Homology of the γ subunit of phosphorylase kinase with cAMP dependent protein kinase by Reimann (1984)
10.1016/S0021-9258(18)71472-5 / J. Biol. Chem / The γ subunit of skeletal muscle phosphorylase kinase contains two non-contiguous domains that act in concert to bind calmodulin by Dasgupta (1989)
10.1016/0167-4889(91)90027-U / Biochim. Biophys. Acta / Intrasteric regulation of protein kinases and phosphatases by Kemp (1991)
10.1126/science.1439761 / Science / Structural basis of the intrasteric regulation of myosin light chain kinases by Knighton (1992)
10.1093/protein/5.8.811 / Protein Eng / Expression of the phosphorylase kinase γ subunit catalytic domain in E. coli by Cox (1992)
10.1007/BF01076753 / Mol. Cell Biochem / Expression, purification, characterisation, and deletion mutations of phosphorylase kinase γ subunit: identification of an inhibitory domain in the γ subunit by Huang (1993)
10.1006/jmbi.1994.0092 / J. Mol. Biol / Expression, purification and crystallisation of phosphorylase kinase catalytic domain by Owen (1995)
10.1126/science.1862342 / Science / Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase by Knighton (1991)
10.1126/science.1862343 / Science / Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase by Knighton (1991)
10.1002/j.1460-2075.1993.tb05725.x / EMBO J / Phosphotransferase and substrate binding mechanism of the cAMP dependent protein kinase subunit from porcine heart as deduced from the 2.0 å structure of the complex with Mn2+ adenylylimidophosphate and inhibitor peptide PKI(5–24) by Bossmeyer (1993)
10.1107/S0907444993000502 / Acta Crystallogr. D / 2.2 Angstrom refined crystal structure of the catalytic domain of cAMP-dependent protein kinase complexed with MnATP and a peptide inhibitor by Knighton (1993)
10.1038/363595a0 / Nature / Crystal structure of cyclin dependent kinase 2 by De Bondt (1993)
10.1038/367704a0 / Nature / Atomic structure of the MAP kinase ERK2 at 2.3 å resolution by Zhang (1994)
10.1038/369581a0 / Nature / Insights into autoregulation from the crystal structure of twitchin kinase by Hu (1994)
10.1038/372746a0 / Nature / Crystal structure of the tyrosine kinase domain of the human insulin receptor by Hubbard (1994)
10.1107/S0108767390010224 / Acta Crystallogr. A / Improved methods for building protein models in electron density maps and location of errors in these models by Jones (1991)
10.1002/j.1460-2075.1986.tb04288.x / EMBO J / The relation between the divergence of sequence and structure in proteins by Chothia (1986)
10.1016/0076-6879(91)00126-H / Methods Enzymol / Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members by Hanks (1991)
{'key': '10.1016/S0969-2126(01)00180-0_BIB28', 'series-title': 'Principles of Nucleic Acid Structure', 'author': 'Saenger', 'year': '1984'} / Principles of Nucleic Acid Structure by Saenger (1984)
10.1021/bi00158a026 / Biochemistry / Analysis by mutagenesis of the ATP binding site of the γ subunit of skeletal muscle phosphorylase kinase expressed using a baculovirus system by Lee (1992)
10.1016/S0021-9258(19)81501-6 / J. Biol. Chem / The ATP-binding site in the gamma subunit of phosphorylase kinase by Tagaya (1988)
10.1016/S0021-9258(18)55332-1 / J. Biol. Chem / The ATPase activity of phosphorylase kinase is regulated in parallel with its protein kinase activity by Paudel (1991)
10.1016/S0021-9258(18)47954-9 / J. Biol. Chem / Properties of the γ subunit of phosphorylase kinase by Kee (1987)
10.1021/bi00151a019 / Biochemistry / Energetic limits of phosphotransfer in the catalytic subunit of cAMP-dependent protein kinase as measured by viscosity experiments by Adams (1992)
10.1021/bi00574a018 / Biochemistry / Magnetic resonance and kinetic studies of the manganese II ion and substrate complexes of the catalytic subunit of adenosine 3′,5′-monophosphate dependent protein kinase from bovine heart by Armstrong (1979)
10.1002/pro.5560021003 / Protein Sci / Crystal structures of the myristylated catalytic subunit of cAMP-dependent protein kinase reveal open and closed conformations by Zheng (1993)
10.1107/S0907444993000423 / Acta Crystallogr. D / 2.2 å refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MnATP and a peptide inhibitor by Zheng (1993)
10.1146/annurev.bi.49.070180.004305 / Annu. Rev. Biochem / Enzyme catalysed phosphoryl transfer reactions by Knowles (1980)
10.1021/bi00153a017 / Biochemistry / Site directed mutagenesis identifies catalytic residues in the active site of Escherichia coli phosphofructokinase by Berger (1992)
10.1007/BF01076755 / Mol. Cell. Biochem / Preparation and functional characterisation of a catalytically active fragment of phosphorylase kinase by Malencik (1993)
10.1021/bi00060a005 / Biochemistry / Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor by Zheng (1993)
10.1107/S0907444993002306 / Acta Crystallogr. D / Structure of the mammalian catalytic of cAMP-dependent protein kinase and an inhibitor peptide displays an open conformation by Karlson (1993)
10.1021/bi00065a018 / Biochemistry / Solution structure of the cAMP-dependent protein kinase catalytic subunit and its contraction upon binding the protein kinase inhibitor peptide by Olah (1993)
10.1016/S1046-2023(05)80146-X / Methods: a companion to Methods Enzymol / The use of glycerol in crystallisation of T7 RNA polymerase: implications for the use of co-solvents in crystallising flexible proteins by Sousa (1990)
10.1016/S0969-2126(00)00036-8 / Structure / Three protein kinase structures define a common motif by Taylor (1994)
10.1126/science.2832943 / Science / A mutation in the catalytic subunit of cAMP-dependent protein kinase that disrupts regulation by Levin (1988)
10.1016/S0021-9258(18)42904-3 / J. Biol. Chem / Systematic mutational analysis of cAMP dependent protein kinase identifies unregulated catalytic subunits and defines regions important for the recognition of the regulatory subunit by Gibbs (1992)
10.1128/MCB.13.4.2332 / Mol. Cell Biol / Autoactivation of the catalytic subunit of cyclic AMP-dependent protein kinase by phosphorylation of Thr197 by Steinberg (1993)
10.1021/bi00008a007 / Biochemistry / Phosphorylation modulates catalytic function and regulation in the cAMP-dependent protein kinase by Adams (1995)
10.1002/j.1460-2075.1991.tb04894.x / EMBO J / Phosphorylation at Thr167 is required for Schizosaccharomyces pombe p34cdc2 function by Gould (1991)
10.1016/0076-6879(91)00127-I / Methods Enzymol / Protein kinase phosphorylation site sequences and consensus specificity motifs: tabulations by Pearson (1991)
10.1016/S0021-9258(17)38058-4 / J. Biol. Chem / Kinetic mechanism and specificity of the phosphorylase kinase reaction by Tabatabai (1978)
10.1016/0076-6879(83)99062-6 / Methods Enzymol / Use of peptide substrates to study the specificity of phosphorylase kinase phosphorylation by Graves (1983)
{'key': '10.1016/S0969-2126(01)00180-0_BIB53', 'series-title': 'Molecular studies on phosphorylase kinase [D. Phil Thesis]', 'author': 'Owen', 'year': '1994'} / Molecular studies on phosphorylase kinase [D. Phil Thesis] by Owen (1994)
10.1002/pro.5560031011 / Protein Sci / Electrostatic effects in the control of glycogen phosphorylase by phosphorylation by Johnson (1994)
10.1002/jcc.540120405 / J. Comput. Chem / A rapid finite difference algorithm, utilising successive over relaxation to solve the Poisson–Boltzmann equation by Nicholls (1991)
10.1073/pnas.44.2.98 / Proc. Natl. Acad. Sci. USA / Application of a theory of enzyme specificity to protein synthesis by Koshland (1958)
10.1002/j.1460-2075.1990.tb07632.x / EMBO J / Identification of a region in segment 1 of gelsolin critical for actin binding by Way (1990)
{'key': '10.1016/S0969-2126(01)00180-0_BIB58', 'series-title': 'Data Collection and Processing', 'first-page': '56', 'article-title': 'DENZO', 'author': 'Otwinowski', 'year': '1993'} / Data Collection and Processing / DENZO by Otwinowski (1993)
10.1107/S0021889890005568 / J. Appl. Crystallogr / Mounting of crystals for macromolecular crystallography in a free standing thin film by Teng (1990)
{'key': '10.1016/S0969-2126(01)00180-0_BIB60', 'series-title': 'X-PLOR: Version 3.1; A System for Protein Crystallography and NMR', 'author': 'Brünger', 'year': '1992'} / X-PLOR: Version 3.1; A System for Protein Crystallography and NMR by Brünger (1992)
10.1107/S0108767393007597 / Acta Crystallogr. A / AMoRe: an automated package for molecular replacement by Navaza (1990)
10.1107/S0108767386099622 / Acta Crystallogr. A / Improved coefficients for map calculation using partial structures with errors by Read (1986)
10.1002/bip.360221211 / Biopolymers / Dictionary of protein secondary structure: pattern recognition of hydrogen bonded and geometrical features by Kabsch (1983)
10.1093/protein/6.1.37 / Protein Eng / ALSCRIPT: a tool to format multiple sequence alignments by Barton (1993)
10.1107/S0021889892009944 / J. Appl. Crystallogr / PROCHECK: a programme to check the stereochemical quality of protein structures by Laskowski (1993)

Dates

Type	When
Created	21 years, 1 month ago (July 23, 2004, 3:10 p.m.)
Deposited	4 years, 2 months ago (June 24, 2021, 10:39 a.m.)
Indexed	1 month, 3 weeks ago (July 4, 2025, 6:06 a.m.)
Issued	30 years, 3 months ago (May 1, 1995)
Published	30 years, 3 months ago (May 1, 1995)
Published Print	30 years, 3 months ago (May 1, 1995)

Funders 0

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BibTeX

@article{Owen_1995, title={Two structures of the catalytic domain of phosphorylase kinase: an active protein kinase complexed with substrate analogue and product}, volume={3}, ISSN={0969-2126}, url={http://dx.doi.org/10.1016/s0969-2126(01)00180-0}, DOI={10.1016/s0969-2126(01)00180-0}, number={5}, journal={Structure}, publisher={Elsevier BV}, author={Owen, DJ and Noble, MEM and Garman, EF and Papageorigiou, AC and Johnson, LN}, year={1995}, month=may, pages={467–482} }

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      "article-title": "An adenosine 3\u2032,5\u2032-monophosphate dependent protein kinase from rabbit muscle",
      "volume": "243",
      "author": "Walsh",
      "year": "1968",
      "journal-title": "J. Biol. Chem"
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      "author": "Cohen",
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      "author": "Paudel",
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      "author": "Zhang",
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      "author": "Hu",
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    {
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      "article-title": "Crystal structure of the tyrosine kinase domain of the human insulin receptor",
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      "journal-title": "Nature"
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      "article-title": "Improved methods for building protein models in electron density maps and location of errors in these models",
      "volume": "47",
      "author": "Jones",
      "year": "1991",
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      "first-page": "823",
      "DOI": "10.1002/j.1460-2075.1986.tb04288.x",
      "article-title": "The relation between the divergence of sequence and structure in proteins",
      "volume": "5",
      "author": "Chothia",
      "year": "1986",
      "journal-title": "EMBO J"
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      "first-page": "38",
      "DOI": "10.1016/0076-6879(91)00126-H",
      "article-title": "Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members",
      "volume": "200",
      "author": "Hanks",
      "year": "1991",
      "journal-title": "Methods Enzymol"
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    {
      "key": "10.1016/S0969-2126(01)00180-0_BIB28",
      "series-title": "Principles of Nucleic Acid Structure",
      "author": "Saenger",
      "year": "1984"
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      "first-page": "10616",
      "DOI": "10.1021/bi00158a026",
      "article-title": "Analysis by mutagenesis of the ATP binding site of the \u03b3 subunit of skeletal muscle phosphorylase kinase expressed using a baculovirus system",
      "volume": "31",
      "author": "Lee",
      "year": "1992",
      "journal-title": "Biochemistry"
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    {
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      "first-page": "10219",
      "DOI": "10.1016/S0021-9258(19)81501-6",
      "article-title": "The ATP-binding site in the gamma subunit of phosphorylase kinase",
      "volume": "263",
      "author": "Tagaya",
      "year": "1988",
      "journal-title": "J. Biol. Chem"
    },
    {
      "key": "10.1016/S0969-2126(01)00180-0_BIB31",
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      "first-page": "16524",
      "DOI": "10.1016/S0021-9258(18)55332-1",
      "article-title": "The ATPase activity of phosphorylase kinase is regulated in parallel with its protein kinase activity",
      "volume": "266",
      "author": "Paudel",
      "year": "1991",
      "journal-title": "J. Biol. Chem"
    },
    {
      "key": "10.1016/S0969-2126(01)00180-0_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "9448",
      "DOI": "10.1016/S0021-9258(18)47954-9",
      "article-title": "Properties of the \u03b3 subunit of phosphorylase kinase",
      "volume": "262",
      "author": "Kee",
      "year": "1987",
      "journal-title": "J. Biol. Chem"
    },
    {
      "key": "10.1016/S0969-2126(01)00180-0_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "8516",
      "DOI": "10.1021/bi00151a019",
      "article-title": "Energetic limits of phosphotransfer in the catalytic subunit of cAMP-dependent protein kinase as measured by viscosity experiments",
      "volume": "31",
      "author": "Adams",
      "year": "1992",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S0969-2126(01)00180-0_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "1230",
      "DOI": "10.1021/bi00574a018",
      "article-title": "Magnetic resonance and kinetic studies of the manganese II ion and substrate complexes of the catalytic subunit of adenosine 3\u2032,5\u2032-monophosphate dependent protein kinase from bovine heart",
      "volume": "18",
      "author": "Armstrong",
      "year": "1979",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S0969-2126(01)00180-0_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "1559",
      "DOI": "10.1002/pro.5560021003",
      "article-title": "Crystal structures of the myristylated catalytic subunit of cAMP-dependent protein kinase reveal open and closed conformations",
      "volume": "2",
      "author": "Zheng",
      "year": "1993",
      "journal-title": "Protein Sci"
    },
    {
      "key": "10.1016/S0969-2126(01)00180-0_BIB36",
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      "first-page": "362",
      "DOI": "10.1107/S0907444993000423",
      "article-title": "2.2 \u00e5 refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MnATP and a peptide inhibitor",
      "volume": "49",
      "author": "Zheng",
      "year": "1993",
      "journal-title": "Acta Crystallogr. D"
    },
    {
      "key": "10.1016/S0969-2126(01)00180-0_BIB37",
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      "first-page": "877",
      "DOI": "10.1146/annurev.bi.49.070180.004305",
      "article-title": "Enzyme catalysed phosphoryl transfer reactions",
      "volume": "49",
      "author": "Knowles",
      "year": "1980",
      "journal-title": "Annu. Rev. Biochem"
    },
    {
      "key": "10.1016/S0969-2126(01)00180-0_BIB38",
      "doi-asserted-by": "crossref",
      "first-page": "9237",
      "DOI": "10.1021/bi00153a017",
      "article-title": "Site directed mutagenesis identifies catalytic residues in the active site of Escherichia coli phosphofructokinase",
      "volume": "31",
      "author": "Berger",
      "year": "1992",
      "journal-title": "Biochemistry"
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    {
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      "first-page": "31",
      "DOI": "10.1007/BF01076755",
      "article-title": "Preparation and functional characterisation of a catalytically active fragment of phosphorylase kinase",
      "volume": "127/128",
      "author": "Malencik",
      "year": "1993",
      "journal-title": "Mol. Cell. Biochem"
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    {
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      "first-page": "2154",
      "DOI": "10.1021/bi00060a005",
      "article-title": "Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor",
      "volume": "32",
      "author": "Zheng",
      "year": "1993",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S0969-2126(01)00180-0_BIB41",
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      "first-page": "381",
      "DOI": "10.1107/S0907444993002306",
      "article-title": "Structure of the mammalian catalytic of cAMP-dependent protein kinase and an inhibitor peptide displays an open conformation",
      "volume": "49",
      "author": "Karlson",
      "year": "1993",
      "journal-title": "Acta Crystallogr. D"
    },
    {
      "key": "10.1016/S0969-2126(01)00180-0_BIB42",
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      "first-page": "3649",
      "DOI": "10.1021/bi00065a018",
      "article-title": "Solution structure of the cAMP-dependent protein kinase catalytic subunit and its contraction upon binding the protein kinase inhibitor peptide",
      "volume": "32",
      "author": "Olah",
      "year": "1993",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S0969-2126(01)00180-0_BIB43",
      "doi-asserted-by": "crossref",
      "first-page": "50",
      "DOI": "10.1016/S1046-2023(05)80146-X",
      "article-title": "The use of glycerol in crystallisation of T7 RNA polymerase: implications for the use of co-solvents in crystallising flexible proteins",
      "volume": "1",
      "author": "Sousa",
      "year": "1990",
      "journal-title": "Methods: a companion to Methods Enzymol"
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    {
      "key": "10.1016/S0969-2126(01)00180-0_BIB44",
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      "first-page": "345",
      "DOI": "10.1016/S0969-2126(00)00036-8",
      "article-title": "Three protein kinase structures define a common motif",
      "volume": "2",
      "author": "Taylor",
      "year": "1994",
      "journal-title": "Structure"
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    {
      "key": "10.1016/S0969-2126(01)00180-0_BIB45",
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      "first-page": "68",
      "DOI": "10.1126/science.2832943",
      "article-title": "A mutation in the catalytic subunit of cAMP-dependent protein kinase that disrupts regulation",
      "volume": "240",
      "author": "Levin",
      "year": "1988",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0969-2126(01)00180-0_BIB46",
      "doi-asserted-by": "crossref",
      "first-page": "4806",
      "DOI": "10.1016/S0021-9258(18)42904-3",
      "article-title": "Systematic mutational analysis of cAMP dependent protein kinase identifies unregulated catalytic subunits and defines regions important for the recognition of the regulatory subunit",
      "volume": "267",
      "author": "Gibbs",
      "year": "1992",
      "journal-title": "J. Biol. Chem"
    },
    {
      "key": "10.1016/S0969-2126(01)00180-0_BIB47",
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      "first-page": "2332",
      "DOI": "10.1128/MCB.13.4.2332",
      "article-title": "Autoactivation of the catalytic subunit of cyclic AMP-dependent protein kinase by phosphorylation of Thr197",
      "volume": "13",
      "author": "Steinberg",
      "year": "1993",
      "journal-title": "Mol. Cell Biol"
    },
    {
      "key": "10.1016/S0969-2126(01)00180-0_BIB48",
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      "first-page": "2447",
      "DOI": "10.1021/bi00008a007",
      "article-title": "Phosphorylation modulates catalytic function and regulation in the cAMP-dependent protein kinase",
      "volume": "34",
      "author": "Adams",
      "year": "1995",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S0969-2126(01)00180-0_BIB49",
      "doi-asserted-by": "crossref",
      "first-page": "3297",
      "DOI": "10.1002/j.1460-2075.1991.tb04894.x",
      "article-title": "Phosphorylation at Thr167 is required for Schizosaccharomyces pombe p34cdc2 function",
      "volume": "10",
      "author": "Gould",
      "year": "1991",
      "journal-title": "EMBO J"
    },
    {
      "key": "10.1016/S0969-2126(01)00180-0_BIB50",
      "doi-asserted-by": "crossref",
      "first-page": "62",
      "DOI": "10.1016/0076-6879(91)00127-I",
      "article-title": "Protein kinase phosphorylation site sequences and consensus specificity motifs: tabulations",
      "volume": "200",
      "author": "Pearson",
      "year": "1991",
      "journal-title": "Methods Enzymol"
    },
    {
      "key": "10.1016/S0969-2126(01)00180-0_BIB51",
      "doi-asserted-by": "crossref",
      "first-page": "2196",
      "DOI": "10.1016/S0021-9258(17)38058-4",
      "article-title": "Kinetic mechanism and specificity of the phosphorylase kinase reaction",
      "volume": "253",
      "author": "Tabatabai",
      "year": "1978",
      "journal-title": "J. Biol. Chem"
    },
    {
      "key": "10.1016/S0969-2126(01)00180-0_BIB52",
      "doi-asserted-by": "crossref",
      "first-page": "268",
      "DOI": "10.1016/0076-6879(83)99062-6",
      "article-title": "Use of peptide substrates to study the specificity of phosphorylase kinase phosphorylation",
      "volume": "99",
      "author": "Graves",
      "year": "1983",
      "journal-title": "Methods Enzymol"
    },
    {
      "key": "10.1016/S0969-2126(01)00180-0_BIB53",
      "series-title": "Molecular studies on phosphorylase kinase [D. Phil Thesis]",
      "author": "Owen",
      "year": "1994"
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      "first-page": "1726",
      "DOI": "10.1002/pro.5560031011",
      "article-title": "Electrostatic effects in the control of glycogen phosphorylase by phosphorylation",
      "volume": "3",
      "author": "Johnson",
      "year": "1994",
      "journal-title": "Protein Sci"
    },
    {
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      "first-page": "435",
      "DOI": "10.1002/jcc.540120405",
      "article-title": "A rapid finite difference algorithm, utilising successive over relaxation to solve the Poisson\u2013Boltzmann equation",
      "volume": "12",
      "author": "Nicholls",
      "year": "1991",
      "journal-title": "J. Comput. Chem"
    },
    {
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      "first-page": "98",
      "DOI": "10.1073/pnas.44.2.98",
      "article-title": "Application of a theory of enzyme specificity to protein synthesis",
      "volume": "44",
      "author": "Koshland",
      "year": "1958",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
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      "first-page": "4103",
      "DOI": "10.1002/j.1460-2075.1990.tb07632.x",
      "article-title": "Identification of a region in segment 1 of gelsolin critical for actin binding",
      "volume": "9",
      "author": "Way",
      "year": "1990",
      "journal-title": "EMBO J"
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    {
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      "series-title": "Data Collection and Processing",
      "first-page": "56",
      "article-title": "DENZO",
      "author": "Otwinowski",
      "year": "1993"
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      "DOI": "10.1107/S0021889890005568",
      "article-title": "Mounting of crystals for macromolecular crystallography in a free standing thin film",
      "volume": "23",
      "author": "Teng",
      "year": "1990",
      "journal-title": "J. Appl. Crystallogr"
    },
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      "key": "10.1016/S0969-2126(01)00180-0_BIB60",
      "series-title": "X-PLOR: Version 3.1; A System for Protein Crystallography and NMR",
      "author": "Br\u00fcnger",
      "year": "1992"
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      "article-title": "AMoRe: an automated package for molecular replacement",
      "volume": "50",
      "author": "Navaza",
      "year": "1990",
      "journal-title": "Acta Crystallogr. A"
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      "article-title": "Improved coefficients for map calculation using partial structures with errors",
      "volume": "42",
      "author": "Read",
      "year": "1986",
      "journal-title": "Acta Crystallogr. A"
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      "article-title": "Dictionary of protein secondary structure: pattern recognition of hydrogen bonded and geometrical features",
      "volume": "22",
      "author": "Kabsch",
      "year": "1983",
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      "DOI": "10.1093/protein/6.1.37",
      "article-title": "ALSCRIPT: a tool to format multiple sequence alignments",
      "volume": "6",
      "author": "Barton",
      "year": "1993",
      "journal-title": "Protein Eng"
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      "article-title": "PROCHECK: a programme to check the stereochemical quality of protein structures",
      "volume": "26",
      "author": "Laskowski",
      "year": "1993",
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