DOI: 10.1016/s0962-8924(00)01853-5. Huntington's disease: the challenge for cell biologists

Huntington's disease: the challenge for cell biologists

10.1016/s0962-8924(00)01853-5

Crossref journal-article

Elsevier BV

Trends in Cell Biology (78)

Bibliography

Tobin, A. J., & Signer, E. R. (2000). Huntingtonâs disease: the challenge for cell biologists. Trends in Cell Biology, 10(12), 531â536.

Authors 2

Allan J. Tobin (first)
Ethan R. Signer (additional)

References 34 Referenced 180

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10.1016/S0896-6273(00)80405-5 / Neuron / Intranuclear neuronal inclusions: a common pathogenic mechanism for glutamine-repeat neurodegenerative diseases? by Ross (1997)
10.1002/1531-8249(199912)46:6<842::AID-ANA6>3.0.CO;2-O / Ann. Neurol. / Huntington aggregates may not predict neuronal death in Huntington's disease by Kuemmerle (1999)
10.1016/0092-8674(93)90585-E / Cell / A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes (1993)
10.1006/nbdi.1996.0018 / Neurobiol. Dis. / Differential expression of normal and mutant Huntington's disease gene alleles by Persichetti (1996)
10.1242/dev.125.8.1529 / Development / Mouse mutant embryos lacking huntingtin are rescued from lethality by wild-type extraembryonic tissues by Dragatsis (1998)
10.1034/j.1399-0004.2000.570101.x / Clin. Genet. / Caspases and neurodegeneration: on the cutting edge of new therapeutic approaches by Wellington (2000)
10.1016/S0092-8674(00)80513-9 / Cell / Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation by Davies (1997)
10.1126/science.277.5334.1990 / Science / Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain by DiFiglia (1997)
10.1006/mcne.1999.0773 / Mol. Cell Neurosci. / Nuclear targeting of mutant Huntingtin increases toxicity by Peters (1999)
10.1523/JNEUROSCI.19-03-00964.1999 / J. Neurosci. / Mutant huntingtin expression in clonal striatal cells: dissociation of inclusion formation and neuronal survival by caspase inhibition by Kim (1999)
10.1093/hmg/7.9.1355 / Hum. Mol. Genet. / A cellular model that recapitulates major pathogenic steps of Huntington's disease by Lunkes (1998)
10.1073/pnas.96.8.4604 / Proc. Natl. Acad. Sci. U. S. A. / Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington's disease pathology by Scherzinger (1999)
10.1073/pnas.96.13.7388 / Proc. Natl. Acad. Sci. U. S. A. / Transglutaminase aggregates huntingtin into nonamyloidogenic polymers, and its enzymatic activity increases in Huntington's disease brain nuclei by Karpuj (1999)
{'key': '10.1016/S0962-8924(00)01853-5_BIB15', 'first-page': '681', 'article-title': 'Transglutaminase as the agent of neurodegenerative diseases due to polyglutamine expansion', 'volume': '46', 'author': 'Kahlem', 'year': '1998', 'journal-title': 'Pathol. Biol.'} / Pathol. Biol. / Transglutaminase as the agent of neurodegenerative diseases due to polyglutamine expansion by Kahlem (1998)
10.1016/S0169-328X(99)00097-2 / Brain Res. Mol. Brain Res. / Localization of rabbit huntingtin using a new panel of monoclonal antibodies by Wilkinson (1999)
10.1006/nbdi.1999.0260 / Neurobiol. Dis. / Mutant huntingtin forms in vivo complexes with distinct context-dependent conformations of the polyglutamine segment by Persichetti (1999)
{'key': '10.1016/S0962-8924(00)01853-5_BIB18', 'first-page': '105', 'article-title': "Modeling protein homopolymeric repeats: possible polyglutamine structural motifs for Huntington's disease", 'volume': '6', 'author': 'Lathrop', 'year': '1998', 'journal-title': 'Ismb'} / Ismb / Modeling protein homopolymeric repeats: possible polyglutamine structural motifs for Huntington's disease by Lathrop (1998)
10.1126/science.282.5391.1079 / Science / Genetic neurodegenerative diseases: the human illness and transgenic models by Price (1998)
10.1055/s-2008-1040853 / Semin. Neurol. / Recent insights into the molecular pathogenesis of Huntington disease by Leavitt (1999)
10.1016/S0092-8674(00)81782-1 / Cell / Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions by Saudou (1998)
10.1083/jcb.143.7.1883 / J. Cell Biol. / Aggresomes: a cellular response to misfolded proteins by Johnston (1998)
10.1016/S0896-6273(00)81035-1 / Neuron / Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice by Cummings (1999)
10.1016/S0092-8674(00)80623-6 / Cell / Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease by Yamamoto (2000)
10.1093/hmg/9.4.503 / Hum. Mol. Genet. / Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice by Wheeler (2000)
10.1073/pnas.100110097 / Proc. Natl. Acad. Sci. U. S. A. / The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription by Steffan (2000)
10.1093/hmg/9.9.1259 / Hum. Mol. Genet. / Decreased expression of striatal signaling genes in a mouse model of Huntington's disease by Luthi-Carter (2000)
10.1038/80538 / Nat. Med. / Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of disease by Chen (2000)
10.1523/JNEUROSCI.19-02-00705.1999 / J. Neurosci. / Generation of neuronal intranuclear inclusions by polyglutamine-GFP: analysis of inclusion clearance and toxicity as a function of polyglutamine length by Moulder (1999)
10.1074/jbc.273.44.28873 / J. Biol. Chem. / Expression of polyglutamine-expanded Huntingtin activates the SEK1-JNK pathway and induces apoptosis in a hippocampal neuronal cell line by Liu (1998)
10.1073/pnas.110078997 / Proc. Natl. Acad. Sci. U. S. A. / Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease by Turmaine (2000)
10.1097/00004647-199903000-00001 / J. Cereb. Blood Flow Metab. / Mitochondria in neurodegeneration: bioenergetic function in cell life and death by Murphy (1999)
10.1006/exnr.1999.7327 / Exp. Neurol. / Decrease in striatal enkephalin mRNA in mouse models of Huntington's disease by Menalled (2000)
10.1016/S0166-2236(00)01584-8 / Trends Neurosci. / Energetics in the pathogenesis of neurodegenerative diseases by Beal (2000)

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 4:59 p.m.)
Deposited	4 years, 3 months ago (May 11, 2021, 3:56 p.m.)
Indexed	2 months, 1 week ago (June 21, 2025, 4:01 a.m.)
Issued	24 years, 8 months ago (Dec. 1, 2000)
Published	24 years, 8 months ago (Dec. 1, 2000)
Published Print	24 years, 8 months ago (Dec. 1, 2000)

Funders 0

None

BibTeX

@article{Tobin_2000, title={Huntington’s disease: the challenge for cell biologists}, volume={10}, ISSN={0962-8924}, url={http://dx.doi.org/10.1016/s0962-8924(00)01853-5}, DOI={10.1016/s0962-8924(00)01853-5}, number={12}, journal={Trends in Cell Biology}, publisher={Elsevier BV}, author={Tobin, Allan J. and Signer, Ethan R.}, year={2000}, month=dec, pages={531–536} }

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