DOI: 10.1016/s0960-9822(01)00652-2. Evidence that Set1, a Factor Required for Methylation of Histone H3, Regulates rDNA Silencing in S. cerevisiae by a Sir2-Independent Mechanism

Evidence that Set1, a Factor Required for Methylation of Histone H3, Regulates rDNA Silencing in S. cerevisiae by a Sir2-Independent Mechanism

10.1016/s0960-9822(01)00652-2

Crossref journal-article

Elsevier BV

Current Biology (78)

Bibliography

Bryk, M., Briggs, S. D., Strahl, B. D., Curcio, M. J., Allis, C. D., & Winston, F. (2002). Evidence that Set1, a Factor Required for Methylation of Histone H3, Regulates rDNA Silencing in S. cerevisiae by a Sir2-Independent Mechanism. Current Biology, 12(2), 165â170.

Authors 6

Mary Bryk (first)
Scott D. Briggs (additional)
Brian D. Strahl (additional)
M.Joan Curcio (additional)
C.David Allis (additional)
Fred Winston (additional)

References 33 Referenced 170

10.1093/nar/27.3.711 / Nucleic Acids Res. / Chromatin disruption and modification by Wolffe (1999)
10.1038/sj.onc.1204324 / Oncogene / An embarrassment of niches by Berger (2001)
10.1038/47412 / Nature / The language of covalent histone modifications by Strahl (2000)
10.1126/science.1063127 / Science / Translating the histone code by Jenuwein (2001)
10.1038/sj.onc.1204325 / Oncogene / Role of protein methylation in chromatin remodeling and transcriptional regulation by Stallcup (2001)
10.1007/s000180050127 / Cell. Mol. Life Sci. / SET domain proteins modulate chromatin domains in eu- and heterochromatin by Jenuwein (1998)
10.1016/S0962-8924(01)02001-3 / Trends Cell Biol. / Re-SET-ting heterochromatin by histone methyltransferases by Jenuwein (2001)
10.1038/35020506 / Nature / Regulation of chromatin structure by site-specific histone H3 methyltransferases by Rea (2000)
10.1126/science.1060118 / Science / Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly by Nakayama (2001)
10.1126/science.1064150 / Science / Transitions in distinct histone h3 methylation patterns at the heterochromatin domain boundaries by Noma (2001)
10.1016/S0021-9258(19)47288-8 / J. Biol. Chem. / Distribution of methylated histones and histone methyltransferases in chicken erythrocyte chromatin by Hendzel (1989)
10.1021/bi00009a023 / Biochemistry / Relationship between methylation and acetylation of arginine-rich histones in cycling and arrested HeLa cells by Annunziato (1995)
10.1073/pnas.96.26.14967 / Proc. Natl. Acad. Sci. USA / Methylation of histone H3 at lysine 4 is highly conserved and correlates with transcriptionally active nuclei in Tetrahymena by Strahl (1999)
10.1093/emboj/16.11.3219 / EMBO J. / Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres by Laible (1997)
10.1091/mbc.8.12.2421 / Mol. Biol. Cell / SET1, a yeast member of the trithorax family, functions in transcriptional silencing and diverse cellular processes by Nislow (1997)
10.1073/pnas.231473398 / Proc. Natl. Acad. Sci. USA / Compass by Miller (2001)
10.1101/gad.940201 / Genes Dev. / Histone H3 lysine 4 methylation is mediated by Set1 and required for rDNA silencing in S. cerevisiae by Briggs (2001)
10.1038/5991 / Nat. Genet. / Interaction between Set1p and checkpoint protein Mec3p in DNA repair and telomere functions by Corda (1999)
10.1101/gad.193901 / Genes Dev. / The set1Δ mutation unveils a novel signaling pathway relayed by the Rad53-dependent hyperphosphorylation of replication protein A that leads to transcriptional activation of repair genes by Schramke (2001)
10.1101/gad.11.2.241 / Genes Dev. / An unusual form of transcriptional silencing in the yeast ribosomal DNA by Smith (1997)
10.1016/0092-8674(89)90681-8 / Cell / A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA by Gottlieb (1989)
10.1101/gad.11.2.255 / Genes Dev. / Transcriptional silencing of Ty1 elements in the RDN1 locus of yeast by Bryk (1997)
10.1016/S0960-9822(00)00298-0 / Curr. Biol. / Two paralogs involved in transcriptional silencing that antagonistically control yeast life span by Roy (2000)
10.1073/pnas.011506198 / Proc. Natl. Acad. Sci. USA / The Sir2 protein family by Shore (2000)
10.1093/emboj/16.11.3243 / EMBO J. / Localization of Sir2p by Gotta (1997)
10.1101/gad.11.1.83 / Genes Dev. / SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeast by Strahl-Bolsinger (1997)
10.1016/S0092-8674(00)80733-3 / Cell / Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex by Shou (1999)
10.1016/S0092-8674(00)80734-5 / Cell / Net1, a Sir2-associated nucleolar protein required for rDNA silencing and nucleolar integrity by Straight (1999)
10.1016/S1097-2765(01)00291-X / Mol. Cell / Net1 stimulates RNA Polymerase I transcription and regulates nucleolar structure independently of controlling mitotic exit by Shou (2001)
10.1101/gad.7.4.592 / Genes Dev. / Transcriptional silencing in yeast is associated with reduced nucleosome acetylation by Braunstein (1993)
10.1128/MCB.16.8.4349 / Mol. Cell. Biol. / Efficient transcriptional silencing in Saccharomyces cerevisiae requires a heterochromatin histone acetylation pattern by Braunstein (1996)
10.1128/MCB.19.4.3184 / Mol. Cell. Biol. / A genetic screen for ribosomal DNA silencing defects identifies multiple DNA replication and chromatin-modulating factors by Smith (1999)
10.1093/genetics/152.3.921 / Genetics / A general requirement for the Sin3-Rpd3 histone deacetylase complex in regulating silencing in Saccharomyces cerevisiae by Sun (1999)

Dates

Type	When
Created	23 years ago (July 25, 2002, 5:34 a.m.)
Deposited	4 years, 3 months ago (May 3, 2021, 9:40 p.m.)
Indexed	3 weeks, 4 days ago (July 28, 2025, 2:43 a.m.)
Issued	23 years, 7 months ago (Jan. 1, 2002)
Published	23 years, 7 months ago (Jan. 1, 2002)
Published Print	23 years, 7 months ago (Jan. 1, 2002)

Funders 0

None

BibTeX

@article{Bryk_2002, title={Evidence that Set1, a Factor Required for Methylation of Histone H3, Regulates rDNA Silencing in S. cerevisiae by a Sir2-Independent Mechanism}, volume={12}, ISSN={0960-9822}, url={http://dx.doi.org/10.1016/s0960-9822(01)00652-2}, DOI={10.1016/s0960-9822(01)00652-2}, number={2}, journal={Current Biology}, publisher={Elsevier BV}, author={Bryk, Mary and Briggs, Scott D. and Strahl, Brian D. and Curcio, M.Joan and Allis, C.David and Winston, Fred}, year={2002}, month=jan, pages={165–170} }

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