DOI: 10.1016/s0960-9822(01)00116-6. Transcriptional and posttranscriptional gene silencing are mechanistically related

Transcriptional and posttranscriptional gene silencing are mechanistically related

10.1016/s0960-9822(01)00116-6

Crossref journal-article

Elsevier BV

Current Biology (78)

Bibliography

Sijen, T., Vijn, I., Rebocho, A., van Blokland, R., Roelofs, D., Mol, J. N. M., & Kooter, J. M. (2001). Transcriptional and posttranscriptional gene silencing are mechanistically related. Current Biology, 11(6), 436â440.

Authors 7

Titia Sijen (first)
Irma Vijn (additional)
Alexandra Rebocho (additional)
Rik van Blokland (additional)
Dick Roelofs (additional)
Joseph N.M. Mol (additional)
Jan M. Kooter (additional)

References 23 Referenced 190

10.1073/pnas.95.23.13959 / Proc Natl Acad Sci USA / Virus resistance and gene silencing in plants can be induced by simultaneous expression of sense and antisense RNA by Waterhouse (1998)
10.1073/pnas.060034297 / Proc Natl Acad Sci USA / Specific and heritable genetic interference by double-stranded RNA in Arabidopsis thaliana by Chuang (2000)
10.1038/35036500 / Nature / Total silencing by intron-spliced hairpin RNAs by Smith (2000)
10.1046/j.1365-313x.2000.00941.x / Plant J / Technical advance by Schweizer (2000)
10.1016/S0958-1669(96)80009-7 / Curr Opin Biotechnol / Ectopic pairing of homologous DNA and post-transcriptional silencing in transgenic plants by Baulcombe (1996)
10.1093/emboj/19.19.5194 / EMBO J / Transcriptional silencing and promoter methylation triggered by double-stranded RNA by Mette (2000)
10.1038/35053110 / Nature / Role for a bidentate ribonuclease in the initiation step of RNA interference by Bernstein (2001)
10.1016/S0092-8674(00)80620-0 / Cell / Rnai by Zamore (2000)
10.1101/gad.862301 / Genes Dev / RNA interference is mediated by 21- and 22-nucleotide RNAs by Elbashir (2001)
10.1016/S0960-9822(00)00862-9 / Curr Biol / DNA methylation and chromatin structure affect transcriptional and post-transcriptional transgene silencing in Arabidopsis by Morel (2000)
10.1105/tpc.2.4.291 / Plant Cell / Flavonoid genes in petunia by van der Krol (1990)
10.1105/tpc.2.4.279 / Plant Cell / Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes in trans by Napoli (1990)
10.1046/j.1365-313X.1994.6060861.x / Plant J / Transgene-mediated suppression of chalcone synthase expression in Petunia hybrida results from an increase in RNA turnover by van Blokland (1994)
10.1126/science.286.5441.950 / Science / A species of small antisense RNA in posttranscriptional gene silencing in plants by Hamilton (1999)
10.1038/35005107 / Nature / An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells by Hammond (2000)
10.1016/S0092-8674(00)80864-8 / Cell / An RNA-dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus by Dalmay (2000)
10.1016/S0092-8674(00)80863-6 / Cell / Arabidopsis SGS2 and SGS3 genes are required for posttranscriptional gene silencing and natural virus resistance by Mourrain (2000)
10.1016/S0092-8674(00)00095-7 / Cell / A viral movement protein prevents spread of the gene silencing signal in Nicotiana benthamiana by Voinnet (2000)
10.1016/0092-8674(94)90119-8 / Cell / RNA-directed de novo methylation of genomic sequences in plants by Wassenegger (1994)
10.1126/science.268.5211.686 / Science / Cosuppression, flower color patterns, and metastable gene expression states by Jorgensen (1995)
10.1046/j.1365-313X.1993.04010089.x / Plant J / Differences in DNA-methylation are associated with a paramutation phenomenon in transgenic petunia by Meyer (1993)
Stam M: Post-transcriptional silencing of flower pigmentation genes in Petunia hybrida by (trans)gene repeats. PhD thesis. Vrije Universiteit, Amsterdam, The Netherlands: 1997.
10.1046/j.1365-313X.1997.12010063.x / Plant J / Post-transcriptional silencing of chalcone synthase in Petunia by inverted transgene repeats by Stam (1997)

Dates

Type	When
Created	22 years, 7 months ago (Jan. 30, 2003, 3:45 p.m.)
Deposited	6 years, 4 months ago (April 20, 2019, 7:57 p.m.)
Indexed	1 week, 1 day ago (Aug. 29, 2025, 5:46 a.m.)
Issued	24 years, 6 months ago (March 1, 2001)
Published	24 years, 6 months ago (March 1, 2001)
Published Print	24 years, 6 months ago (March 1, 2001)

Funders 0

None

BibTeX

@article{Sijen_2001, title={Transcriptional and posttranscriptional gene silencing are mechanistically related}, volume={11}, ISSN={0960-9822}, url={http://dx.doi.org/10.1016/s0960-9822(01)00116-6}, DOI={10.1016/s0960-9822(01)00116-6}, number={6}, journal={Current Biology}, publisher={Elsevier BV}, author={Sijen, Titia and Vijn, Irma and Rebocho, Alexandra and van Blokland, Rik and Roelofs, Dick and Mol, Joseph N.M. and Kooter, Jan M.}, year={2001}, month=mar, pages={436–440} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        29
      ]
    ],
    "date-time": "2025-08-29T09:46:04Z",
    "timestamp": 1756460764821
  },
  "reference-count": 23,
  "publisher": "Elsevier BV",
  "issue": "6",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2001,
            3,
            1
          ]
        ],
        "date-time": "2001-03-01T00:00:00Z",
        "timestamp": 983404800000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2013,
            7,
            17
          ]
        ],
        "date-time": "2013-07-17T00:00:00Z",
        "timestamp": 1374019200000
      },
      "content-version": "vor",
      "delay-in-days": 4521,
      "URL": "https://www.elsevier.com/open-access/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2001,
        3
      ]
    ]
  },
  "DOI": "10.1016/s0960-9822(01)00116-6",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2003,
        1,
        30
      ]
    ],
    "date-time": "2003-01-30T20:45:15Z",
    "timestamp": 1043959515000
  },
  "page": "436-440",
  "source": "Crossref",
  "is-referenced-by-count": 190,
  "title": "Transcriptional and posttranscriptional gene silencing are mechanistically related",
  "prefix": "10.1016",
  "volume": "11",
  "author": [
    {
      "given": "Titia",
      "family": "Sijen",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Irma",
      "family": "Vijn",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Alexandra",
      "family": "Rebocho",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Rik",
      "family": "van Blokland",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Dick",
      "family": "Roelofs",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Joseph N.M.",
      "family": "Mol",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Jan M.",
      "family": "Kooter",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/S0960-9822(01)00116-6_BIB1",
      "doi-asserted-by": "crossref",
      "first-page": "13959",
      "DOI": "10.1073/pnas.95.23.13959",
      "article-title": "Virus resistance and gene silencing in plants can be induced by simultaneous expression of sense and antisense RNA",
      "volume": "95",
      "author": "Waterhouse",
      "year": "1998",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "10.1016/S0960-9822(01)00116-6_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "4985",
      "DOI": "10.1073/pnas.060034297",
      "article-title": "Specific and heritable genetic interference by double-stranded RNA in Arabidopsis thaliana",
      "volume": "97",
      "author": "Chuang",
      "year": "2000",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "10.1016/S0960-9822(01)00116-6_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "319",
      "DOI": "10.1038/35036500",
      "article-title": "Total silencing by intron-spliced hairpin RNAs",
      "volume": "407",
      "author": "Smith",
      "year": "2000",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0960-9822(01)00116-6_BIB4",
      "doi-asserted-by": "crossref",
      "first-page": "895",
      "DOI": "10.1046/j.1365-313x.2000.00941.x",
      "article-title": "Technical advance",
      "volume": "24",
      "author": "Schweizer",
      "year": "2000",
      "journal-title": "Plant J"
    },
    {
      "key": "10.1016/S0960-9822(01)00116-6_BIB5",
      "doi-asserted-by": "crossref",
      "first-page": "173",
      "DOI": "10.1016/S0958-1669(96)80009-7",
      "article-title": "Ectopic pairing of homologous DNA and post-transcriptional silencing in transgenic plants",
      "volume": "7",
      "author": "Baulcombe",
      "year": "1996",
      "journal-title": "Curr Opin Biotechnol"
    },
    {
      "key": "10.1016/S0960-9822(01)00116-6_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "5194",
      "DOI": "10.1093/emboj/19.19.5194",
      "article-title": "Transcriptional silencing and promoter methylation triggered by double-stranded RNA",
      "volume": "19",
      "author": "Mette",
      "year": "2000",
      "journal-title": "EMBO J"
    },
    {
      "key": "10.1016/S0960-9822(01)00116-6_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "363",
      "DOI": "10.1038/35053110",
      "article-title": "Role for a bidentate ribonuclease in the initiation step of RNA interference",
      "volume": "409",
      "author": "Bernstein",
      "year": "2001",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0960-9822(01)00116-6_BIB8",
      "doi-asserted-by": "crossref",
      "first-page": "25",
      "DOI": "10.1016/S0092-8674(00)80620-0",
      "article-title": "Rnai",
      "volume": "101",
      "author": "Zamore",
      "year": "2000",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0960-9822(01)00116-6_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "188",
      "DOI": "10.1101/gad.862301",
      "article-title": "RNA interference is mediated by 21- and 22-nucleotide RNAs",
      "volume": "15",
      "author": "Elbashir",
      "year": "2001",
      "journal-title": "Genes Dev"
    },
    {
      "key": "10.1016/S0960-9822(01)00116-6_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "1591",
      "DOI": "10.1016/S0960-9822(00)00862-9",
      "article-title": "DNA methylation and chromatin structure affect transcriptional and post-transcriptional transgene silencing in Arabidopsis",
      "volume": "10",
      "author": "Morel",
      "year": "2000",
      "journal-title": "Curr Biol"
    },
    {
      "key": "10.1016/S0960-9822(01)00116-6_BIB11",
      "doi-asserted-by": "crossref",
      "first-page": "291",
      "DOI": "10.1105/tpc.2.4.291",
      "article-title": "Flavonoid genes in petunia",
      "volume": "2",
      "author": "van der Krol",
      "year": "1990",
      "journal-title": "Plant Cell"
    },
    {
      "key": "10.1016/S0960-9822(01)00116-6_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "279",
      "DOI": "10.1105/tpc.2.4.279",
      "article-title": "Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes in trans",
      "volume": "2",
      "author": "Napoli",
      "year": "1990",
      "journal-title": "Plant Cell"
    },
    {
      "key": "10.1016/S0960-9822(01)00116-6_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "861",
      "DOI": "10.1046/j.1365-313X.1994.6060861.x",
      "article-title": "Transgene-mediated suppression of chalcone synthase expression in Petunia hybrida results from an increase in RNA turnover",
      "volume": "6",
      "author": "van Blokland",
      "year": "1994",
      "journal-title": "Plant J"
    },
    {
      "key": "10.1016/S0960-9822(01)00116-6_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "950",
      "DOI": "10.1126/science.286.5441.950",
      "article-title": "A species of small antisense RNA in posttranscriptional gene silencing in plants",
      "volume": "286",
      "author": "Hamilton",
      "year": "1999",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0960-9822(01)00116-6_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "293",
      "DOI": "10.1038/35005107",
      "article-title": "An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells",
      "volume": "404",
      "author": "Hammond",
      "year": "2000",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0960-9822(01)00116-6_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "543",
      "DOI": "10.1016/S0092-8674(00)80864-8",
      "article-title": "An RNA-dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus",
      "volume": "101",
      "author": "Dalmay",
      "year": "2000",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0960-9822(01)00116-6_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "533",
      "DOI": "10.1016/S0092-8674(00)80863-6",
      "article-title": "Arabidopsis SGS2 and SGS3 genes are required for posttranscriptional gene silencing and natural virus resistance",
      "volume": "101",
      "author": "Mourrain",
      "year": "2000",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0960-9822(01)00116-6_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "157",
      "DOI": "10.1016/S0092-8674(00)00095-7",
      "article-title": "A viral movement protein prevents spread of the gene silencing signal in Nicotiana benthamiana",
      "volume": "103",
      "author": "Voinnet",
      "year": "2000",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0960-9822(01)00116-6_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "567",
      "DOI": "10.1016/0092-8674(94)90119-8",
      "article-title": "RNA-directed de novo methylation of genomic sequences in plants",
      "volume": "76",
      "author": "Wassenegger",
      "year": "1994",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0960-9822(01)00116-6_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "686",
      "DOI": "10.1126/science.268.5211.686",
      "article-title": "Cosuppression, flower color patterns, and metastable gene expression states",
      "volume": "268",
      "author": "Jorgensen",
      "year": "1995",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0960-9822(01)00116-6_BIB21",
      "doi-asserted-by": "crossref",
      "first-page": "89",
      "DOI": "10.1046/j.1365-313X.1993.04010089.x",
      "article-title": "Differences in DNA-methylation are associated with a paramutation phenomenon in transgenic petunia",
      "volume": "4",
      "author": "Meyer",
      "year": "1993",
      "journal-title": "Plant J"
    },
    {
      "key": "10.1016/S0960-9822(01)00116-6_BIB22",
      "unstructured": "Stam M: Post-transcriptional silencing of flower pigmentation genes in Petunia hybrida by (trans)gene repeats. PhD thesis. Vrije Universiteit, Amsterdam, The Netherlands: 1997."
    },
    {
      "key": "10.1016/S0960-9822(01)00116-6_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "63",
      "DOI": "10.1046/j.1365-313X.1997.12010063.x",
      "article-title": "Post-transcriptional silencing of chalcone synthase in Petunia by inverted transgene repeats",
      "volume": "12",
      "author": "Stam",
      "year": "1997",
      "journal-title": "Plant J"
    }
  ],
  "container-title": "Current Biology",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0960982201001166?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0960982201001166?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2019,
        4,
        20
      ]
    ],
    "date-time": "2019-04-20T23:57:25Z",
    "timestamp": 1555804645000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0960982201001166"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2001,
        3
      ]
    ]
  },
  "references-count": 23,
  "journal-issue": {
    "issue": "6",
    "published-print": {
      "date-parts": [
        [
          2001,
          3
        ]
      ]
    }
  },
  "alternative-id": [
    "S0960982201001166"
  ],
  "URL": "http://dx.doi.org/10.1016/S0960-9822(01)00116-6",
  "relation": {},
  "ISSN": [
    "0960-9822"
  ],
  "subject": [],
  "container-title-short": "Current Biology",
  "published": {
    "date-parts": [
      [
        2001,
        3
      ]
    ]
  }
}