DOI: 10.1016/s0960-9822(00)00673-4. INCENP binds the Aurora-related kinase AIRK2 and is required to target it to chromosomes, the central spindle and cleavage furrow

INCENP binds the Aurora-related kinase AIRK2 and is required to target it to chromosomes, the central spindle and cleavage furrow

10.1016/s0960-9822(00)00673-4

Crossref journal-article

Elsevier BV

Current Biology (78)

Bibliography

Adams, R. R., Wheatleya, S. P., Gouldsworthy, A. M., Kandels-Lewis, S. E., Carmena, M., Smythe, C., Gerloff, D. L., & Earnshaw, W. C. (2000). INCENP binds the Aurora-related kinase AIRK2 and is required to target it to chromosomes, the central spindle and cleavage furrow. Current Biology, 10(17), 1075â1078.

Authors 8

R.R. Adams (first)
S.P. Wheatleya (additional)
A.M. Gouldsworthy (additional)
S.E. Kandels-Lewis (additional)
M. Carmena (additional)
C. Smythe (additional)
D.L. Gerloff (additional)
W.C. Earnshaw (additional)

References 21 Referenced 265

10.1007/BF00337241 / Chromosoma / Chromosomal passengers: toward an integrated view of mitosis by Earnshaw (1991)
10.1083/jcb.105.5.2053 / J Cell Biol / The inner centromere protein (INCENP) antigens: movement from inner centromere to midbody during mitosis by Cooke (1987)
10.1093/emboj/17.3.667 / EMBO J / AIM-1: a mammalian midbody-associated protein required for cytokinesis by Terada (1998)
10.1242/jcs.112.21.3591 / J Cell Sci / Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases by Giet (1999)
10.1242/jcs.99.3.523 / J Cell Sci / Telophase disc: a new mammalian mitotic organelle that bisects telophase cells with a possible function in cytokinesis by Andreassen (1991)
10.1083/jcb.140.5.991 / J Cell Biol / A dominant mutant of inner centromere protein (INCENP), a chromosomal protein, disrupts prometaphase congression and cytokinesis by Mackay (1998)
10.1093/hmg/8.7.1145 / Hum Mol Genet / Defective chromosome segregation, microtubule bundling and nuclear bridging in inner centromere protein gene (Incenp)-disrupted mice by Cutts (1999)
10.1083/jcb.143.6.1635 / J Cell Biol / AIR-2: An Aurora/Ipl1-related protein kinase associated with chromosomes and midbody microtubules is required for polar body extrusion and cytokinesis in Caenorhabditis elegans embryos by Schumacher (1998)
10.1016/S0962-8924(99)01658-X / Trends Cell Biol / The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis by Bischoff (1999)
10.1074/jbc.274.21.15005 / J Biol Chem / The Xenopus laevis aurora-related protein kinase pEg2 associates with and phosphorylates the kinesin-related protein XlEg5 by Giet (1999)
10.1038/349132a0 / Nature / Cyclin is degraded by the ubiquitin pathway by Glotzer (1991)
10.1101/gad.14.6.655 / Genes Dev / The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1 by Pfleger (2000)
10.1093/nar/25.17.3389 / Nucleic Acids Res / Gapped BLAST and PSI-BLAST: a new generation of protein database search programs by Altschul (1997)
10.1083/jcb.145.7.1381 / J Cell Biol / Sli15 associates with the ipl1 protein kinase to promote proper chromosome segregation in Saccharomyces cerevisiae by Kim (1999)
10.1101/gad.13.5.532 / Genes Dev / The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast by Biggins (1999)
10.1128/MCB.14.7.4731 / Mol Cell Biol / Type 1 protein phosphatase acts in opposition to IpL1 protein kinase in regulating yeast chromosome segregation by Francisco (1994)
10.1083/jcb.136.6.1169 / J Cell Biol / Chromosomal proteins and cytokinesis: patterns of cleavage furrow formation and inner centromere protein positioning in mitotic heterokaryons and mid-anaphase cells by Eckley (1997)
10.1101/SQB.1993.058.01.077 / Cold Spring Harb Symp Quant Biol / The INCENPs: structural and functional analysis of a family of chromosome passenger proteins by Mackay (1993)
10.1016/0014-4827(91)90427-V / Exp Cell Res / Blasticidin S-resistance gene (bsr): a novel selectable marker for mammalian cells by Izumi (1999)
{'key': '10.1016/S0960-9822(00)00673-4_BIB20', 'first-page': '4811', 'article-title': 'Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells', 'volume': '58', 'author': 'Tatsuka', 'year': '1998', 'journal-title': 'Cancer Res'} / Cancer Res / Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells by Tatsuka (1998)
10.1002/pro.5560060606 / Protein Sci / MultiCoil: a program for predicting two- and three-stranded coiled coils by Wolf (1997)

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 10:19 a.m.)
Deposited	2 years, 4 months ago (April 9, 2023, 1:52 a.m.)
Indexed	1 month ago (Aug. 2, 2025, 12:56 a.m.)
Issued	25 years ago (Sept. 1, 2000)
Published	25 years ago (Sept. 1, 2000)
Published Print	25 years ago (Sept. 1, 2000)

Funders 0

None

BibTeX

@article{Adams_2000, title={INCENP binds the Aurora-related kinase AIRK2 and is required to target it to chromosomes, the central spindle and cleavage furrow}, volume={10}, ISSN={0960-9822}, url={http://dx.doi.org/10.1016/s0960-9822(00)00673-4}, DOI={10.1016/s0960-9822(00)00673-4}, number={17}, journal={Current Biology}, publisher={Elsevier BV}, author={Adams, R.R. and Wheatleya, S.P. and Gouldsworthy, A.M. and Kandels-Lewis, S.E. and Carmena, M. and Smythe, C. and Gerloff, D.L. and Earnshaw, W.C.}, year={2000}, month=sep, pages={1075–1078} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        2
      ]
    ],
    "date-time": "2025-08-02T04:56:29Z",
    "timestamp": 1754110589774
  },
  "reference-count": 21,
  "publisher": "Elsevier BV",
  "issue": "17",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2000,
            9,
            1
          ]
        ],
        "date-time": "2000-09-01T00:00:00Z",
        "timestamp": 967766400000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2013,
            7,
            17
          ]
        ],
        "date-time": "2013-07-17T00:00:00Z",
        "timestamp": 1374019200000
      },
      "content-version": "vor",
      "delay-in-days": 4702,
      "URL": "https://www.elsevier.com/open-access/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2000,
        9
      ]
    ]
  },
  "DOI": "10.1016/s0960-9822(00)00673-4",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        7,
        25
      ]
    ],
    "date-time": "2002-07-25T14:19:09Z",
    "timestamp": 1027606749000
  },
  "page": "1075-1078",
  "source": "Crossref",
  "is-referenced-by-count": 265,
  "title": "INCENP binds the Aurora-related kinase AIRK2 and is required to target it to chromosomes, the central spindle and cleavage furrow",
  "prefix": "10.1016",
  "volume": "10",
  "author": [
    {
      "given": "R.R.",
      "family": "Adams",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "S.P.",
      "family": "Wheatleya",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "A.M.",
      "family": "Gouldsworthy",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "S.E.",
      "family": "Kandels-Lewis",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "M.",
      "family": "Carmena",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "C.",
      "family": "Smythe",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "D.L.",
      "family": "Gerloff",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "W.C.",
      "family": "Earnshaw",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/S0960-9822(00)00673-4_BIB1",
      "doi-asserted-by": "crossref",
      "first-page": "139",
      "DOI": "10.1007/BF00337241",
      "article-title": "Chromosomal passengers: toward an integrated view of mitosis",
      "volume": "100",
      "author": "Earnshaw",
      "year": "1991",
      "journal-title": "Chromosoma"
    },
    {
      "key": "10.1016/S0960-9822(00)00673-4_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "2053",
      "DOI": "10.1083/jcb.105.5.2053",
      "article-title": "The inner centromere protein (INCENP) antigens: movement from inner centromere to midbody during mitosis",
      "volume": "105",
      "author": "Cooke",
      "year": "1987",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "10.1016/S0960-9822(00)00673-4_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "667",
      "DOI": "10.1093/emboj/17.3.667",
      "article-title": "AIM-1: a mammalian midbody-associated protein required for cytokinesis",
      "volume": "17",
      "author": "Terada",
      "year": "1998",
      "journal-title": "EMBO J"
    },
    {
      "key": "10.1016/S0960-9822(00)00673-4_BIB4",
      "doi-asserted-by": "crossref",
      "first-page": "3591",
      "DOI": "10.1242/jcs.112.21.3591",
      "article-title": "Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases",
      "volume": "112",
      "author": "Giet",
      "year": "1999",
      "journal-title": "J Cell Sci"
    },
    {
      "key": "10.1016/S0960-9822(00)00673-4_BIB5",
      "doi-asserted-by": "crossref",
      "first-page": "523",
      "DOI": "10.1242/jcs.99.3.523",
      "article-title": "Telophase disc: a new mammalian mitotic organelle that bisects telophase cells with a possible function in cytokinesis",
      "volume": "99",
      "author": "Andreassen",
      "year": "1991",
      "journal-title": "J Cell Sci"
    },
    {
      "key": "10.1016/S0960-9822(00)00673-4_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "991",
      "DOI": "10.1083/jcb.140.5.991",
      "article-title": "A dominant mutant of inner centromere protein (INCENP), a chromosomal protein, disrupts prometaphase congression and cytokinesis",
      "volume": "140",
      "author": "Mackay",
      "year": "1998",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "10.1016/S0960-9822(00)00673-4_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "1145",
      "DOI": "10.1093/hmg/8.7.1145",
      "article-title": "Defective chromosome segregation, microtubule bundling and nuclear bridging in inner centromere protein gene (Incenp)-disrupted mice",
      "volume": "8",
      "author": "Cutts",
      "year": "1999",
      "journal-title": "Hum Mol Genet"
    },
    {
      "key": "10.1016/S0960-9822(00)00673-4_BIB8",
      "doi-asserted-by": "crossref",
      "first-page": "1635",
      "DOI": "10.1083/jcb.143.6.1635",
      "article-title": "AIR-2: An Aurora/Ipl1-related protein kinase associated with chromosomes and midbody microtubules is required for polar body extrusion and cytokinesis in Caenorhabditis elegans embryos",
      "volume": "143",
      "author": "Schumacher",
      "year": "1998",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "10.1016/S0960-9822(00)00673-4_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "454",
      "DOI": "10.1016/S0962-8924(99)01658-X",
      "article-title": "The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis",
      "volume": "9",
      "author": "Bischoff",
      "year": "1999",
      "journal-title": "Trends Cell Biol"
    },
    {
      "key": "10.1016/S0960-9822(00)00673-4_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "15005",
      "DOI": "10.1074/jbc.274.21.15005",
      "article-title": "The Xenopus laevis aurora-related protein kinase pEg2 associates with and phosphorylates the kinesin-related protein XlEg5",
      "volume": "274",
      "author": "Giet",
      "year": "1999",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "10.1016/S0960-9822(00)00673-4_BIB11",
      "doi-asserted-by": "crossref",
      "first-page": "132",
      "DOI": "10.1038/349132a0",
      "article-title": "Cyclin is degraded by the ubiquitin pathway",
      "volume": "349",
      "author": "Glotzer",
      "year": "1991",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0960-9822(00)00673-4_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "655",
      "DOI": "10.1101/gad.14.6.655",
      "article-title": "The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1",
      "volume": "14",
      "author": "Pfleger",
      "year": "2000",
      "journal-title": "Genes Dev"
    },
    {
      "key": "10.1016/S0960-9822(00)00673-4_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "3389",
      "DOI": "10.1093/nar/25.17.3389",
      "article-title": "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs",
      "volume": "25",
      "author": "Altschul",
      "year": "1997",
      "journal-title": "Nucleic Acids Res"
    },
    {
      "key": "10.1016/S0960-9822(00)00673-4_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "1381",
      "DOI": "10.1083/jcb.145.7.1381",
      "article-title": "Sli15 associates with the ipl1 protein kinase to promote proper chromosome segregation in Saccharomyces cerevisiae",
      "volume": "145",
      "author": "Kim",
      "year": "1999",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "10.1016/S0960-9822(00)00673-4_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "532",
      "DOI": "10.1101/gad.13.5.532",
      "article-title": "The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast",
      "volume": "13",
      "author": "Biggins",
      "year": "1999",
      "journal-title": "Genes Dev"
    },
    {
      "key": "10.1016/S0960-9822(00)00673-4_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "4731",
      "DOI": "10.1128/MCB.14.7.4731",
      "article-title": "Type 1 protein phosphatase acts in opposition to IpL1 protein kinase in regulating yeast chromosome segregation",
      "volume": "14",
      "author": "Francisco",
      "year": "1994",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "10.1016/S0960-9822(00)00673-4_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "1169",
      "DOI": "10.1083/jcb.136.6.1169",
      "article-title": "Chromosomal proteins and cytokinesis: patterns of cleavage furrow formation and inner centromere protein positioning in mitotic heterokaryons and mid-anaphase cells",
      "volume": "136",
      "author": "Eckley",
      "year": "1997",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "10.1016/S0960-9822(00)00673-4_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "697",
      "DOI": "10.1101/SQB.1993.058.01.077",
      "article-title": "The INCENPs: structural and functional analysis of a family of chromosome passenger proteins",
      "volume": "58",
      "author": "Mackay",
      "year": "1993",
      "journal-title": "Cold Spring Harb Symp Quant Biol"
    },
    {
      "key": "10.1016/S0960-9822(00)00673-4_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "229",
      "DOI": "10.1016/0014-4827(91)90427-V",
      "article-title": "Blasticidin S-resistance gene (bsr): a novel selectable marker for mammalian cells",
      "volume": "197",
      "author": "Izumi",
      "year": "1999",
      "journal-title": "Exp Cell Res"
    },
    {
      "key": "10.1016/S0960-9822(00)00673-4_BIB20",
      "first-page": "4811",
      "article-title": "Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells",
      "volume": "58",
      "author": "Tatsuka",
      "year": "1998",
      "journal-title": "Cancer Res"
    },
    {
      "key": "10.1016/S0960-9822(00)00673-4_BIB21",
      "doi-asserted-by": "crossref",
      "first-page": "1179",
      "DOI": "10.1002/pro.5560060606",
      "article-title": "MultiCoil: a program for predicting two- and three-stranded coiled coils",
      "volume": "6",
      "author": "Wolf",
      "year": "1997",
      "journal-title": "Protein Sci"
    }
  ],
  "container-title": "Current Biology",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0960982200006734?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0960982200006734?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        4,
        9
      ]
    ],
    "date-time": "2023-04-09T05:52:31Z",
    "timestamp": 1681019551000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0960982200006734"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2000,
        9
      ]
    ]
  },
  "references-count": 21,
  "journal-issue": {
    "issue": "17",
    "published-print": {
      "date-parts": [
        [
          2000,
          9
        ]
      ]
    }
  },
  "alternative-id": [
    "S0960982200006734"
  ],
  "URL": "http://dx.doi.org/10.1016/S0960-9822(00)00673-4",
  "relation": {},
  "ISSN": [
    "0960-9822"
  ],
  "subject": [],
  "container-title-short": "Current Biology",
  "published": {
    "date-parts": [
      [
        2000,
        9
      ]
    ]
  }
}