DOI: 10.1016/s0960-9822(00)00544-3. Enforced polarisation and locomotion of fibroblasts lacking microtubules

Enforced polarisation and locomotion of fibroblasts lacking microtubules

10.1016/s0960-9822(00)00544-3

Crossref journal-article

Elsevier BV

Current Biology (78)

Bibliography

Kaverina, I., Krylyshkina, O., Gimona, M., Beningo, K., Wang, Y.-L., & Small, J. V. (2000). Enforced polarisation and locomotion of fibroblasts lacking microtubules. Current Biology, 10(12), 739â742.

Authors 6

Irina Kaverina (first)
Olga Krylyshkina (additional)
Mario Gimona (additional)
Karen Beningo (additional)
Yu-Li Wang (additional)
J.Victor Small (additional)

References 19 Referenced 54

{'key': '10.1016/S0960-9822(00)00544-3_BIB1', 'series-title': 'Cell Motility', 'first-page': '279', 'article-title': 'Effects of colcemid on morphogenetic processes and locomotion of fibroblasts', 'author': 'Vasiliev', 'year': '1976'} / Cell Motility / Effects of colcemid on morphogenetic processes and locomotion of fibroblasts by Vasiliev (1976)
10.1038/9018 / Nat Cell Biol / Microtubule growth activates Rac1 to promote lamellipodial protrusion in fibroblasts by Waterman-Storer (1999)
10.1083/jcb.142.1.181 / J Cell Biol / Targeting, capture and stabilisation of microtubules at early focal adhesions by Kaverina (1998)
10.1083/jcb.146.5.1033 / J Cell Biol / Microtubule targeting of substrate contacts promotes their relaxation and dissociation by Kaverina (1999)
10.1242/jcs.42.1.81 / J Cell Sci / Formation of cell-to-substrate contacts during fibroblast motility: an interference reflection study by Izzard (1980)
10.1091/mbc.10.4.935 / Mol Biol Cell / High resolution detection of mechanical forces exerted by locomoting fibroblasts on the substrate by Pelham (1999)
10.1016/0092-8674(86)90259-X / Cell / Arg-Gly-Asp: a versatile cell recognition signal by Ruoslahti (1986)
10.1083/jcb.107.3.1231 / J Cell Biol / Synthetic peptide GRGDS induces dissociation of alpha actinin and vinculin from the sites of focal contact by Stickel (1988)
10.1016/S0960-9822(99)80286-3 / Curr Biol / Interplay between Rac and Rho in the control of substrate contact dynamics by Rottner (1999)
10.1083/jcb.147.5.1009 / J Cell Biol / Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behaviour by Sander (1999)
10.1038/12068 / Nat Cell Biol / Rac regulates phosphorylation of the myosin-II heavy chain, actinomyosin disassembly and cell spreading by Van Leeuwen (1999)
10.1083/jcb.81.3.684 / J Cell Biol / Induction of spreading during fibroblast movement by Chen (1979)
{'key': '10.1016/S0960-9822(00)00544-3_BIB13', 'series-title': 'Cell Adhesion and Motility', 'first-page': '409', 'article-title': 'Mechanisms of fibroblast locomotion', 'author': 'Dunn', 'year': '1980'} / Cell Adhesion and Motility / Mechanisms of fibroblast locomotion by Dunn (1980)
10.1016/S0960-9822(99)80042-6 / Curr Biol / Self polarization and directional motility of cytoplasm by Verkhovsky (1999)
10.1016/S0960-9822(00)00357-2 / Curr Biol / Contact dynamics during keratocyte motility by Anderson (2000)
10.1083/jcb.145.3.589 / J Cell Biol / Separation of propulsive and adhesive traction stresses in locomoting keratocytes by Oliver (1999)
10.1038/310058a0 / Nature / Persistent, directional motility of cells and cytoplasmic fragments in the absence of microtubules by Euteneuer (1984)
10.1083/jcb.133.6.1403 / J Cell Biol / Rho-stimulated contractility drives the formation of stress fibres and focal adhesions by Chrzanowska-Wodnicka (1996)
10.1126/science.286.5442.1172 / Science / Focal adhesion motility revealed in stationary fibroblasts by Smilenov (1999)

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 10:50 p.m.)
Deposited	1 year, 4 months ago (May 6, 2024, 11:20 a.m.)
Indexed	1 month ago (Aug. 3, 2025, 6:59 p.m.)
Issued	25 years, 3 months ago (June 1, 2000)
Published	25 years, 3 months ago (June 1, 2000)
Published Print	25 years, 3 months ago (June 1, 2000)

Funders 0

None

BibTeX

@article{Kaverina_2000, title={Enforced polarisation and locomotion of fibroblasts lacking microtubules}, volume={10}, ISSN={0960-9822}, url={http://dx.doi.org/10.1016/s0960-9822(00)00544-3}, DOI={10.1016/s0960-9822(00)00544-3}, number={12}, journal={Current Biology}, publisher={Elsevier BV}, author={Kaverina, Irina and Krylyshkina, Olga and Gimona, Mario and Beningo, Karen and Wang, Yu-Li and Small, J.Victor}, year={2000}, month=jun, pages={739–742} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        3
      ]
    ],
    "date-time": "2025-08-03T22:59:35Z",
    "timestamp": 1754261975833
  },
  "reference-count": 19,
  "publisher": "Elsevier BV",
  "issue": "12",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2000,
            6,
            1
          ]
        ],
        "date-time": "2000-06-01T00:00:00Z",
        "timestamp": 959817600000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2000,
            6,
            1
          ]
        ],
        "date-time": "2000-06-01T00:00:00Z",
        "timestamp": 959817600000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/legal/tdmrep-license"
    },
    {
      "start": {
        "date-parts": [
          [
            2013,
            7,
            17
          ]
        ],
        "date-time": "2013-07-17T00:00:00Z",
        "timestamp": 1374019200000
      },
      "content-version": "vor",
      "delay-in-days": 4794,
      "URL": "http://www.elsevier.com/open-access/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [
      "cell.com",
      "elsevier.com",
      "sciencedirect.com"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        2000,
        6
      ]
    ]
  },
  "DOI": "10.1016/s0960-9822(00)00544-3",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        7,
        26
      ]
    ],
    "date-time": "2002-07-26T02:50:19Z",
    "timestamp": 1027651819000
  },
  "page": "739-742",
  "update-policy": "http://dx.doi.org/10.1016/elsevier_cm_policy",
  "source": "Crossref",
  "is-referenced-by-count": 54,
  "title": "Enforced polarisation and locomotion of fibroblasts lacking microtubules",
  "prefix": "10.1016",
  "volume": "10",
  "author": [
    {
      "given": "Irina",
      "family": "Kaverina",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Olga",
      "family": "Krylyshkina",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Mario",
      "family": "Gimona",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Karen",
      "family": "Beningo",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Yu-Li",
      "family": "Wang",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "J.Victor",
      "family": "Small",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/S0960-9822(00)00544-3_BIB1",
      "series-title": "Cell Motility",
      "first-page": "279",
      "article-title": "Effects of colcemid on morphogenetic processes and locomotion of fibroblasts",
      "author": "Vasiliev",
      "year": "1976"
    },
    {
      "key": "10.1016/S0960-9822(00)00544-3_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "45",
      "DOI": "10.1038/9018",
      "article-title": "Microtubule growth activates Rac1 to promote lamellipodial protrusion in fibroblasts",
      "volume": "1",
      "author": "Waterman-Storer",
      "year": "1999",
      "journal-title": "Nat Cell Biol"
    },
    {
      "key": "10.1016/S0960-9822(00)00544-3_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "181",
      "DOI": "10.1083/jcb.142.1.181",
      "article-title": "Targeting, capture and stabilisation of microtubules at early focal adhesions",
      "volume": "142",
      "author": "Kaverina",
      "year": "1998",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "10.1016/S0960-9822(00)00544-3_BIB4",
      "doi-asserted-by": "crossref",
      "first-page": "1033",
      "DOI": "10.1083/jcb.146.5.1033",
      "article-title": "Microtubule targeting of substrate contacts promotes their relaxation and dissociation",
      "volume": "146",
      "author": "Kaverina",
      "year": "1999",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "10.1016/S0960-9822(00)00544-3_BIB5",
      "doi-asserted-by": "crossref",
      "first-page": "81",
      "DOI": "10.1242/jcs.42.1.81",
      "article-title": "Formation of cell-to-substrate contacts during fibroblast motility: an interference reflection study",
      "volume": "42",
      "author": "Izzard",
      "year": "1980",
      "journal-title": "J Cell Sci"
    },
    {
      "key": "10.1016/S0960-9822(00)00544-3_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "935",
      "DOI": "10.1091/mbc.10.4.935",
      "article-title": "High resolution detection of mechanical forces exerted by locomoting fibroblasts on the substrate",
      "volume": "10",
      "author": "Pelham",
      "year": "1999",
      "journal-title": "Mol Biol Cell"
    },
    {
      "key": "10.1016/S0960-9822(00)00544-3_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "517",
      "DOI": "10.1016/0092-8674(86)90259-X",
      "article-title": "Arg-Gly-Asp: a versatile cell recognition signal",
      "volume": "44",
      "author": "Ruoslahti",
      "year": "1986",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0960-9822(00)00544-3_BIB8",
      "doi-asserted-by": "crossref",
      "first-page": "1231",
      "DOI": "10.1083/jcb.107.3.1231",
      "article-title": "Synthetic peptide GRGDS induces dissociation of alpha actinin and vinculin from the sites of focal contact",
      "volume": "107",
      "author": "Stickel",
      "year": "1988",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "10.1016/S0960-9822(00)00544-3_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "640",
      "DOI": "10.1016/S0960-9822(99)80286-3",
      "article-title": "Interplay between Rac and Rho in the control of substrate contact dynamics",
      "volume": "9",
      "author": "Rottner",
      "year": "1999",
      "journal-title": "Curr Biol"
    },
    {
      "key": "10.1016/S0960-9822(00)00544-3_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "1009",
      "DOI": "10.1083/jcb.147.5.1009",
      "article-title": "Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behaviour",
      "volume": "147",
      "author": "Sander",
      "year": "1999",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "10.1016/S0960-9822(00)00544-3_BIB11",
      "doi-asserted-by": "crossref",
      "first-page": "242",
      "DOI": "10.1038/12068",
      "article-title": "Rac regulates phosphorylation of the myosin-II heavy chain, actinomyosin disassembly and cell spreading",
      "volume": "1",
      "author": "Van Leeuwen",
      "year": "1999",
      "journal-title": "Nat Cell Biol"
    },
    {
      "key": "10.1016/S0960-9822(00)00544-3_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "684",
      "DOI": "10.1083/jcb.81.3.684",
      "article-title": "Induction of spreading during fibroblast movement",
      "volume": "81",
      "author": "Chen",
      "year": "1979",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "10.1016/S0960-9822(00)00544-3_BIB13",
      "series-title": "Cell Adhesion and Motility",
      "first-page": "409",
      "article-title": "Mechanisms of fibroblast locomotion",
      "author": "Dunn",
      "year": "1980"
    },
    {
      "key": "10.1016/S0960-9822(00)00544-3_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "11",
      "DOI": "10.1016/S0960-9822(99)80042-6",
      "article-title": "Self polarization and directional motility of cytoplasm",
      "volume": "9",
      "author": "Verkhovsky",
      "year": "1999",
      "journal-title": "Curr Biol"
    },
    {
      "key": "10.1016/S0960-9822(00)00544-3_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "253",
      "DOI": "10.1016/S0960-9822(00)00357-2",
      "article-title": "Contact dynamics during keratocyte motility",
      "volume": "10",
      "author": "Anderson",
      "year": "2000",
      "journal-title": "Curr Biol"
    },
    {
      "key": "10.1016/S0960-9822(00)00544-3_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "589",
      "DOI": "10.1083/jcb.145.3.589",
      "article-title": "Separation of propulsive and adhesive traction stresses in locomoting keratocytes",
      "volume": "145",
      "author": "Oliver",
      "year": "1999",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "10.1016/S0960-9822(00)00544-3_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "58",
      "DOI": "10.1038/310058a0",
      "article-title": "Persistent, directional motility of cells and cytoplasmic fragments in the absence of microtubules",
      "volume": "310",
      "author": "Euteneuer",
      "year": "1984",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0960-9822(00)00544-3_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "1403",
      "DOI": "10.1083/jcb.133.6.1403",
      "article-title": "Rho-stimulated contractility drives the formation of stress fibres and focal adhesions",
      "volume": "133",
      "author": "Chrzanowska-Wodnicka",
      "year": "1996",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "10.1016/S0960-9822(00)00544-3_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "1172",
      "DOI": "10.1126/science.286.5442.1172",
      "article-title": "Focal adhesion motility revealed in stationary fibroblasts",
      "volume": "286",
      "author": "Smilenov",
      "year": "1999",
      "journal-title": "Science"
    }
  ],
  "container-title": "Current Biology",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0960982200005443?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0960982200005443?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2024,
        5,
        6
      ]
    ],
    "date-time": "2024-05-06T15:20:04Z",
    "timestamp": 1715008804000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0960982200005443"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2000,
        6
      ]
    ]
  },
  "references-count": 19,
  "journal-issue": {
    "issue": "12",
    "published-print": {
      "date-parts": [
        [
          2000,
          6
        ]
      ]
    }
  },
  "alternative-id": [
    "S0960982200005443"
  ],
  "URL": "http://dx.doi.org/10.1016/S0960-9822(00)00544-3",
  "relation": {},
  "ISSN": [
    "0960-9822"
  ],
  "subject": [],
  "container-title-short": "Current Biology",
  "published": {
    "date-parts": [
      [
        2000,
        6
      ]
    ]
  },
  "assertion": [
    {
      "value": "Elsevier",
      "name": "publisher",
      "label": "This article is maintained by"
    },
    {
      "value": "Enforced polarisation and locomotion of fibroblasts lacking microtubules",
      "name": "articletitle",
      "label": "Article Title"
    },
    {
      "value": "Current Biology",
      "name": "journaltitle",
      "label": "Journal Title"
    },
    {
      "value": "https://doi.org/10.1016/S0960-9822(00)00544-3",
      "name": "articlelink",
      "label": "CrossRef DOI link to publisher maintained version"
    },
    {
      "value": "converted-article",
      "name": "content_type",
      "label": "Content Type"
    },
    {
      "value": "Copyright \u00a9 2000 Elsevier Science Ltd. All rights reserved.",
      "name": "copyright",
      "label": "Copyright"
    }
  ]
}