Crossref journal-article
Elsevier BV
European Journal of Cancer (78)
Bibliography

Vermeulen, P. B., Gasparini, G., Fox, S. B., Toi, M., Martin, L., Mcculloch, P., Pezzella, F., Viale, G., Weidner, N., Harris, A. L., & Dirix, L. Y. (1996). Quantification of angiogenesis in solid human tumours: an international consensus on the methodology and criteria of evaluation. European Journal of Cancer, 32(14), 2474–2484.

Authors 11
  1. P.B. Vermeulen (first)
  2. G. Gasparini (additional)
  3. S.B. Fox (additional)
  4. M. Toi (additional)
  5. L. Martin (additional)
  6. P. Mcculloch (additional)
  7. F. Pezzella (additional)
  8. G. Viale (additional)
  9. N. Weidner (additional)
  10. A.L. Harris (additional)
  11. L.Y. Dirix (additional)
References 78 Referenced 520
  1. 10.1056/NEJM199512283332608 / N Engl J Med / Clinical applications of research on angiogenesis by Folkman (1995)
  2. 10.1093/jnci/82.1.4 / J Natl Cancer Inst / What is the evidence that tumors are angiogenesis dependent? by Folkman (1990)
  3. 10.1093/jnci/86.17.1303 / J Natl Cancer Inst / Altered angiogenesis underlying age-dependent changes in tumor growth by Pili (1994)
  4. 10.1126/science.7521539 / Science / Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1 by Dameron (1994)
  5. {'key': '10.1016/S0959-8049(96)00379-6_BIB5', 'first-page': '963', 'article-title': 'Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression', 'volume': '9', 'author': 'Kieser', 'year': '1994', 'journal-title': 'Oncogene'} / Oncogene / Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression by Kieser (1994)
  6. {'key': '10.1016/S0959-8049(96)00379-6_BIB6', 'first-page': '4575', 'article-title': 'Mutant ras oncogenes upregulate VEGF/NPF expression: implications for induction and inhibition of tumor angiogenesis', 'volume': '55', 'author': 'Rak', 'year': '1995', 'journal-title': 'Cancer Res'} / Cancer Res / Mutant ras oncogenes upregulate VEGF/NPF expression: implications for induction and inhibition of tumor angiogenesis by Rak (1995)
  7. 10.1038/359843a0 / Nature / Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis by Schweiki (1992)
  8. {'key': '10.1016/S0959-8049(96)00379-6_BIB8', 'first-page': '4606', 'article-title': 'Hypoxia-mediated induction of acidic/basic fibroblast growth factor and platelet-derived growth factor in mononuclear phagocytes stimulates growth of hypoxic endothelial cells', 'volume': '92', 'author': 'Kuwabara', 'year': '1995'} / Hypoxia-mediated induction of acidic/basic fibroblast growth factor and platelet-derived growth factor in mononuclear phagocytes stimulates growth of hypoxic endothelial cells by Kuwabara (1995)
  9. 10.1038/nm0296-167 / Nature Med / Tumor angiogenesis and tissue factor by Folkman (1996)
  10. 10.1093/oxfordjournals.annonc.a059043 / Ann Oncol / Microvessel density, endothelial cell proliferation and tumour cell proliferation in human colorectal adenocarcinomas by Vermeulen (1995)
  11. {'key': '10.1016/S0959-8049(96)00379-6_BIB11', 'first-page': '4161', 'article-title': 'Relationship of endothelial cell proliferation to tumor vascularity in human breast cancer', 'volume': '53', 'author': 'Fox', 'year': '1993', 'journal-title': 'Cancer Res'} / Cancer Res / Relationship of endothelial cell proliferation to tumor vascularity in human breast cancer by Fox (1993)
  12. 10.1038/bjc.1996.166 / Br J Cancer / Association of vascular endothelial growth factor expression with intratumoral microvessel density and tumour cell proliferation in human epidermoid lung cancer by Mattern (1996)
  13. 10.1172/JCI118227 / J Clin Invest / Anti-integrin αvβ3 blocks human breast cancer growth and angiogenesis in human skin by Brooks (1995)
  14. {'key': '10.1016/S0959-8049(96)00379-6_BIB14', 'first-page': '997', 'article-title': 'Quantitative relationship of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation', 'volume': '34', 'author': 'Liotta', 'year': '1974', 'journal-title': 'Cancer Res'} / Cancer Res / Quantitative relationship of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation by Liotta (1974)
  15. 10.1016/S0140-6736(95)92345-4 / Lancet / Association between tumour angiogenesis and tumour cell shedding into effluent venous blood during breast cancer surgery by McCulloch (1995)
  16. 10.1038/nm0195-27 / Nature Med / Angiogenesis in cancer, vascular, rheumatoid and other disease by Folkman (1995)
  17. {'key': '10.1016/S0959-8049(96)00379-6_BIB17', 'first-page': '961', 'article-title': 'Vascular endothelial growth factor and platelet-derived endothelial cell growth factor are frequently coexpressed in highly vascularized human breast cancer', 'volume': '1', 'author': 'Toi', 'year': '1995', 'journal-title': 'Clin Cancer Res'} / Clin Cancer Res / Vascular endothelial growth factor and platelet-derived endothelial cell growth factor are frequently coexpressed in highly vascularized human breast cancer by Toi (1995)
  18. 10.1007/BF00666040 / Breast Cancer Res Treat / Tumor angiogenesis in breast cancer: its importance as a prognostic indicator and the association with vascular endothelial growth factor expression by Toi (1995)
  19. 10.1111/j.1349-7006.1994.tb02904.x / Jpn J Cancer Res / Association of vascular endothelial growth factor expression with tumor angiogenesis and with early relapse in primary breast cancer by Toi (1994)
  20. 10.1002/(SICI)1097-0142(19960315)77:6<1101::AID-CNCR15>3.0.CO;2-5 / Cancer / Quantitative analysis of vascular endothelial growth factor in primary breast cancer by Toi (1996)
  21. {'key': '10.1016/S0959-8049(96)00379-6_BIB21', 'first-page': '1189', 'article-title': 'Expression of vascular endothelial growth factor and its possible relation with neo-vascularization in human brain tumors', 'volume': '55', 'author': 'Samoto', 'year': '1995', 'journal-title': 'Cancer Res'} / Cancer Res / Expression of vascular endothelial growth factor and its possible relation with neo-vascularization in human brain tumors by Samoto (1995)
  22. {'key': '10.1016/S0959-8049(96)00379-6_BIB22', 'first-page': '2185', 'article-title': 'Concentration of vascular endothelial growth factor in the serum and tumor tissue of brain tumor patients', 'volume': '56', 'author': 'Takano', 'year': '1996', 'journal-title': 'Cancer Res'} / Cancer Res / Concentration of vascular endothelial growth factor in the serum and tumor tissue of brain tumor patients by Takano (1996)
  23. 10.1016/S0140-6736(94)91280-7 / Lancet / Microvessel count and cerebrospinal fluid basic fibroblast growth factor in children with brain tumours by Li (1994)
  24. 10.1002/(SICI)1097-0142(19960301)77:5<858::AID-CNCR8>3.0.CO;2-A / Cancer / Prognostic value of vascular endothelial growth factor expression in gastric carcinoma by Maeda (1996)
  25. 10.1093/jnci/87.16.1237 / J Natl Cancer Inst / Vascular permeability factor (vascular endothelial growth factor) expression and angiogenesis in cervical neoplasia by Guidi (1995)
  26. 10.1093/oxfordjournals.annonc.a059322 / Ann Oncol / Vascular endothelial growth factor (VEGF) mRNA expression in human tumor models of different histologies by Berger (1995)
  27. 10.1007/BF01833260 / Breast Cancer Res Treat / Urokinase (uPA) and its inhibitor PAI-1 are strong and independent prognostic factors in node negative breast cancer by Jänicke (1993)
  28. 10.3109/02841869009089997 / Acta Oncol / Metastasis and angiogenesis by Mahadevan (1990)
  29. 10.1038/bjc.1995.419 / Br J Cancer / Urokinase and macrophages in tumour angiogenesis by Hildebrand (1995)
  30. 10.1148/radiology.198.3.8628876 / Radiology / Mammary carcinoma model: correlation of macromolecular contrast-enhanced MR imaging characterizations of tumor microvasculature and histologic capillary density by van Dijke (1996)
  31. 10.1016/0140-6736(92)93150-L / Lancet / Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as an indicator of node metastasis and survival in breast cancer by Horak (1992)
  32. {'key': '10.1016/S0959-8049(96)00379-6_BIB32', 'first-page': '9', 'article-title': 'Intratumor microvessel density as a prognostic factor in cancer', 'volume': '147', 'author': 'Weidner', 'year': '1995', 'journal-title': 'Am J Pathol'} / Am J Pathol / Intratumor microvessel density as a prognostic factor in cancer by Weidner (1995)
  33. 10.1136/jcp.43.9.752 / J Clin Pathol / JC70: a new monoclonal antibody that detects vascular endothelium associated antigen on routinely processed tissue sections by Parums (1990)
  34. {'key': '10.1016/S0959-8049(96)00379-6_BIB34', 'first-page': '60', 'article-title': 'Ulex europaeus I Lectin as marker for vascular endothelium in human tissues', 'volume': '47', 'author': 'Holthöffer', 'year': '1982', 'journal-title': 'Lab Invest'} / Lab Invest / Ulex europaeus I Lectin as marker for vascular endothelium in human tissues by Holthöffer (1982)
  35. {'key': '10.1016/S0959-8049(96)00379-6_BIB35', 'first-page': '690', 'article-title': 'Leukocyte antigen CD34 is expressed by a subset of cultured endothelial cells and on endothelial abluminal microprocesses in the tumor stroma', 'volume': '62', 'author': 'Schlingemann', 'year': '1990', 'journal-title': 'Lab Invest'} / Lab Invest / Leukocyte antigen CD34 is expressed by a subset of cultured endothelial cells and on endothelial abluminal microprocesses in the tumor stroma by Schlingemann (1990)
  36. {'key': '10.1016/S0959-8049(96)00379-6_BIB36', 'first-page': '82', 'article-title': 'Endothelial cell markers CD31, CD34 and BNH9 antibody to H- and Y-antigens—evaluation of their specificity and sensitivity in the diagnosis of vascular tumors and comparison with von Willebrand factor', 'volume': '1', 'author': 'Miettinen', 'year': '1994', 'journal-title': 'Mod Pathol'} / Mod Pathol / Endothelial cell markers CD31, CD34 and BNH9 antibody to H- and Y-antigens—evaluation of their specificity and sensitivity in the diagnosis of vascular tumors and comparison with von Willebrand factor by Miettinen (1994)
  37. 10.1177/34.2.2418100 / J Histochem Cytochem / Immunohistochemical and immunochemical characterization of a new endothelial cell-specific antigen by Alles (1986)
  38. 10.1002/bies.950161208 / BioEssays / Differentiation of endothelial cells: analysis of the constitutive and activated endothelial cell phenotypes by Augustin (1994)
  39. 10.1111/1523-1747.ep12580902 / J Invest Dermatol / Monoclonal antibody-defined human endothelial antigens as vascular markers by Ruiter (1989)
  40. {'key': '10.1016/S0959-8049(96)00379-6_BIB40', 'first-page': '920', 'article-title': 'Angiogenesis and tumour growth (correspondence—reply by Folkman J)', 'volume': '334', 'author': 'van Netten', 'year': '1995', 'journal-title': 'N Engl J Med'} / N Engl J Med / Angiogenesis and tumour growth (correspondence—reply by Folkman J) by van Netten (1995)
  41. 10.1016/0960-9776(95)90142-6 / The Breast / Standardising the methodology of vessel density in breast cancer using immuno-histochemistry and tumour microangiography by Martin (1995)
  42. 10.1038/bjc.1995.68 / Br J Cancer / Microvessel quantification in primary colorectal carcinoma: an immuno-histochemical study by Vermeulen (1995)
  43. {'key': '10.1016/S0959-8049(96)00379-6_BIB43', 'first-page': '1623', 'article-title': 'Up-regulation of endoglin on vascular endothelial cells in human solid tumors: implications for diagnosis and therapy', 'volume': '1', 'author': 'Burrows', 'year': '1995', 'journal-title': 'Clin Cancer Res'} / Clin Cancer Res / Up-regulation of endoglin on vascular endothelial cells in human solid tumors: implications for diagnosis and therapy by Burrows (1995)
  44. 10.1084/jem.164.2.661 / J Exp Med / Induction and detection of a human endothelial activation antigen in vivo by Cotran (1986)
  45. 10.1002/ijc.2910540303 / Int J Cancer / A monoclonal antibody detects heterogeneity in vascular endothelium of tumours and normal tissues by Wang (1993)
  46. 10.1002/(SICI)1096-9896(199604)178:4<363::AID-PATH491>3.0.CO;2-8 / J Pathol / CD 105 and angiogenesis by Kumar (1996)
  47. 10.1056/NEJM199101033240101 / N Engl J Med / Tumor angio-genesis and metastasis-correlation in invasive breast carcinoma by Weidner (1991)
  48. {'key': '10.1016/S0959-8049(96)00379-6_BIB48', 'first-page': '992', 'article-title': 'Heterogeneity and reproducibility of microvessel counts in breast cancer', 'volume': '73', 'author': 'de Jong', 'year': '1995', 'journal-title': 'Lab Invest'} / Lab Invest / Heterogeneity and reproducibility of microvessel counts in breast cancer by de Jong (1995)
  49. {'key': '10.1016/S0959-8049(96)00379-6_BIB49', 'first-page': '702', 'article-title': 'Vascular heterogeneity in breast cancer assessed by microangiography and immunohistochemistry', 'volume': '83', 'author': 'Martin', 'year': '1996', 'journal-title': 'Br J Surg'} / Br J Surg / Vascular heterogeneity in breast cancer assessed by microangiography and immunohistochemistry by Martin (1996)
  50. {'key': '10.1016/S0959-8049(96)00379-6_BIB50', 'first-page': '1141', 'article-title': 'Assessment of tumour vascularity as a prognostic factor in lymph node negative invasive breast cancer', 'volume': '29A', 'author': 'Van Hoef', 'year': '1993', 'journal-title': 'Eur J Cancer'} / Eur J Cancer / Assessment of tumour vascularity as a prognostic factor in lymph node negative invasive breast cancer by Van Hoef (1993)
  51. {'key': '10.1016/S0959-8049(96)00379-6_BIB51', 'first-page': '75', 'article-title': 'Microvessel density quantification in breast carcinomas. Assessment by light microscopy vs. a computer-aided image analysis system', 'volume': '3', 'author': 'Barbareschi', 'year': '1995', 'journal-title': 'Appl Immunohistochem'} / Appl Immunohistochem / Microvessel density quantification in breast carcinomas. Assessment by light microscopy vs. a computer-aided image analysis system by Barbareschi (1995)
  52. 10.1093/jnci/87.23.1797 / J Natl Cancer Inst / Tumor angiogenesis as a prognostic assay for invasive ductal breast carcinoma by Vermeulen (1995)
  53. 10.1093/jnci/87.13.997 / J Natl Cancer Inst / Tumor angiogenesis as a prognostic assay for invasive ductal breast carcinoma by Axelsson (1995)
  54. 10.1002/(SICI)1097-0142(19960515)77:10<2077::AID-CNCR17>3.0.CO;2-S / Cancer / Endothelial area as a prognostic indicator for invasive breast carcinoma by Simpson (1996)
  55. Vermeulen PB, Libura M, Libura J, et al. Influence of investigator experience and microscopic field size on microvessel density in node-negative breast carcinoma. Breast Cancer Res Treat, in press. (10.1023/A:1005737524541)
  56. 10.1111/j.1600-0560.1993.tb00661.x / J Cutan Pathol / Expression of platelet-endothelial cell adhesion molecule-1 (PECAM-1) during melanoma-induced angiogenesis in vivo by Berger (1993)
  57. 10.1093/jnci/86.8.614 / J Natl Cancer Inst / Microvessel density and distribution in ductal carcinoma in situ of the breast by Guidi (1994)
  58. 10.1093/jnci/84.24.1875 / J Natl Cancer Inst / Tumor angiogenesis: a new and independent prognostic indicator in early-stage breast carcinoma by Weidner (1992)
  59. 10.1002/path.1711770310 / J Pathol / Quantitation and prognostic value of breast cancer angiogenesis: comparison of microvessel density, Chalkley count, and computer image analysis by Fox (1995)
  60. 10.1111/j.1464-410X.1994.tb07122.x / Br J Urol / Quantification of angiogenesis as an independent predictor of prognosis in invasive bladder carcinomas by Dickinson (1994)
  61. {'key': '10.1016/S0959-8049(96)00379-6_BIB61', 'first-page': '1191', 'article-title': 'Determination of angiogenesis adds information to estrogen receptor status in predicting the efficacy of adjuvant tamoxifen in node-positive breast cancer patients', 'volume': '2', 'author': 'Gasparini', 'year': '1996', 'journal-title': 'Clin Cancer Res'} / Clin Cancer Res / Determination of angiogenesis adds information to estrogen receptor status in predicting the efficacy of adjuvant tamoxifen in node-positive breast cancer patients by Gasparini (1996)
  62. 10.1093/ajcp/103.4.443 / Am J Clin Pathol / CD31 quantitative immunocytochemical assays in breast carcinomas—correlation with current prognostic factors by Charpin (1995)
  63. {'key': '10.1016/S0959-8049(96)00379-6_BIB63', 'series-title': 'Impt Adv Oncol', 'first-page': '167', 'article-title': 'Tumoral vascularity as a prognostic factor in cancer', 'author': 'Weidner', 'year': '1996'} / Impt Adv Oncol / Tumoral vascularity as a prognostic factor in cancer by Weidner (1996)
  64. 10.1038/bjc.1994.192 / Br J Cancer / Statistical aspects of prognostic factor studies in oncology by Simon (1994)
  65. {'key': '10.1016/S0959-8049(96)00379-6_BIB65', 'first-page': '90', 'article-title': 'Serum levels of bFGF and VEGF in patients with metastatic solid tumors', 'volume': '15', 'author': 'Vermeulen', 'year': '1996'} / Serum levels of bFGF and VEGF in patients with metastatic solid tumors by Vermeulen (1996)
  66. {'key': '10.1016/S0959-8049(96)00379-6_BIB66', 'first-page': '821', 'article-title': 'Concentrations of vascular endothelial growth factor in the sera of normal controls and cancer patients', 'volume': '2', 'author': 'Yamamoto', 'year': '1996', 'journal-title': 'Clin Cancer Res'} / Clin Cancer Res / Concentrations of vascular endothelial growth factor in the sera of normal controls and cancer patients by Yamamoto (1996)
  67. 10.1148/radiology.197.1.7568850 / Radiology / Benign and malignant breast lesions: differentiation with echo-planar MR imaging by Hulka (1995)
  68. {'key': '10.1016/S0959-8049(96)00379-6_BIB68', 'first-page': '128', 'article-title': 'The use of breast MRI as an analytic tool to demonstrate anatomic extent, vascularity, and biological diversity in breast cancer', 'volume': '15', 'author': 'Esserman', 'year': '1996'} / The use of breast MRI as an analytic tool to demonstrate anatomic extent, vascularity, and biological diversity in breast cancer by Esserman (1996)
  69. 10.1093/jnci/86.8.635 / J Natl Cancer Inst / Angiogenesis and risk of breast cancer in women with fibrocystic disease by Guinebretière (1994)
  70. {'key': '10.1016/S0959-8049(96)00379-6_BIB70', 'first-page': '1375', 'article-title': 'Predictive and prognostic markers in a series of patients with head and neck squamous cell invasive carcinoma treated with concurrent chemoradiation therapy', 'volume': '1', 'author': 'Gasparini', 'year': '1995', 'journal-title': 'Clin Cancer Res'} / Clin Cancer Res / Predictive and prognostic markers in a series of patients with head and neck squamous cell invasive carcinoma treated with concurrent chemoradiation therapy by Gasparini (1995)
  71. {'key': '10.1016/S0959-8049(96)00379-6_BIB71', 'first-page': '131', 'article-title': 'Tumor angiogenesis predicts clinical outcome of node-positive breast cancer patients treated with adjuvant hormone therapy or chemotherapy', 'volume': '1', 'author': 'Gasparini', 'year': '1995', 'journal-title': 'Cancer J Sci Am'} / Cancer J Sci Am / Tumor angiogenesis predicts clinical outcome of node-positive breast cancer patients treated with adjuvant hormone therapy or chemotherapy by Gasparini (1995)
  72. 10.1002/(SICI)1097-0215(19960621)69:3<205::AID-IJC10>3.0.CO;2-6 / Int J Cancer / Prognostic and predictive value of tumour angiogenesis in ovarian carcinomas by Gasparini (1996)
  73. 10.1097/00001813-199603000-00005 / Anti-Cancer Drugs / Long-term results of continuous treatment with recombinant interferon-α in patients with metastatic carcinoid tumors—an antiangiogenic effect? by Dirix (1996)
  74. 10.1093/jnci/83.8.569 / J Natl Cancer Inst / Computed tomographic density of metastatic lymph nodes as a treatment-related prognostic factor in advanced head and neck cancer by Munck (1991)
  75. 10.1200/JCO.1995.13.3.765 / J Clin Oncol / Clinical importance of the determination of tumor angiogenesis in breast carcinoma: much more than a new prognostic tool by Gasparini (1995)
  76. 10.1093/oxfordjournals.annonc.a010631 / Ann Oncol / Clinical studies with angiogenesis inhibitors: biological rationale and challenges for their evaluation by Gasparini (1996)
  77. 10.1200/JCO.1994.12.3.454 / J Clin Oncol / Tumor micro-vessel density, p53 expression, tumor size, and peritumoral lymphatic vessel invasion are relevant prognostic markers in node-negative breast carcinoma by Gasparini (1994)
  78. 10.1002/path.1711770407 / J Pathol / The increased expression of adhesion molecules ICAM-3, E- and P-selectins on breast cancer endothelium by Fox (1995)
Dates
Type When
Created 23 years, 1 month ago (July 25, 2002, 1:46 p.m.)
Deposited 6 years, 4 months ago (April 24, 2019, 9:56 a.m.)
Indexed 3 days, 12 hours ago (Sept. 3, 2025, 7:03 a.m.)
Issued 28 years, 9 months ago (Dec. 1, 1996)
Published 28 years, 9 months ago (Dec. 1, 1996)
Published Print 28 years, 9 months ago (Dec. 1, 1996)
Funders 0

None

@article{Vermeulen_1996, title={Quantification of angiogenesis in solid human tumours: an international consensus on the methodology and criteria of evaluation}, volume={32}, ISSN={0959-8049}, url={http://dx.doi.org/10.1016/s0959-8049(96)00379-6}, DOI={10.1016/s0959-8049(96)00379-6}, number={14}, journal={European Journal of Cancer}, publisher={Elsevier BV}, author={Vermeulen, P.B. and Gasparini, G. and Fox, S.B. and Toi, M. and Martin, L. and Mcculloch, P. and Pezzella, F. and Viale, G. and Weidner, N. and Harris, A.L. and Dirix, L.Y.}, year={1996}, month=dec, pages={2474–2484} }