DOI: 10.1016/s0959-4388(00)00211-7. Transcription-dependent and -independent control of neuronal survival by the PI3K

Transcription-dependent and -independent control of neuronal survival by the PI3K–Akt signaling pathway

10.1016/s0959-4388(00)00211-7

Crossref journal-article

Elsevier BV

Current Opinion in Neurobiology (78)

Bibliography

Brunet, A., Datta, S. R., & Greenberg, M. E. (2001). Transcription-dependent and -independent control of neuronal survival by the PI3KâAkt signaling pathway. Current Opinion in Neurobiology, 11(3), 297â305.

Authors 3

Anne Brunet (first)
Sandeep Robert Datta (additional)
Michael E Greenberg (additional)

References 84 Referenced 980

10.1016/S0896-6273(00)81004-1 / Neuron / Neuronal cell death by Pettmann (1998)
10.1101/gad.10.22.2849 / Genes Dev / TrkB and TrkC neurotrophin receptors cooperate in promoting survival of hippocampal and cerebellar granule neurons by Minichiello (1996)
10.1016/S0896-6273(00)80938-1 / Neuron / Abnormal cerebellar development and foliation in BDNF−/− mice reveals a role for neurotrophins in CNS patterning by Schwartz (1997)
10.1101/gad.841400 / Genes Dev / Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system by Bibel (2000)
10.1083/jcb.106.3.829 / J Cell Biol / Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation by Martin (1988)
10.1083/jcb.143.6.1691 / J Cell Biol / p53 is essential for developmental neuron death as regulated by the TrkA and p75 neurotrophin receptors by Aloyz (1998)
10.1128/MCB.19.1.751 / Mol Cell Biol / Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to fas ligand induction and cell death by Le-Niculescu (1999)
10.1083/jcb.147.5.1049 / J Cell Biol / Programmed cell death of embryonic motoneurons triggered through the Fas death receptor by Raoul (1999)
10.1101/gad.13.15.1899 / Genes Dev / BCL-2 family members and the mitochondria in apoptosis by Gross (1999)
10.1101/gad.12.11.1551 / Genes Dev / Proteases to die for by Cryns (1998)
10.1101/gad.13.3.239 / Genes Dev / IAP family proteins — suppressors of apoptosis by Deveraux (1999)
10.1016/S0092-8674(00)00008-8 / Cell / Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition by Du (2000)
10.1016/S0092-8674(00)00009-X / Cell / Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins by Verhagen (2000)
10.1016/S0896-6273(00)80587-5 / Neuron / Evidence of a novel event during neuronal death: development of competence-to-die in response to cytoplasmic cytochrome c by Deshmukh (1998)
10.1016/S0092-8674(00)81688-8 / Cell / Signaling — 2000 and beyond by Hunter (2000)
10.1042/0264-6021:3460561 / Biochem J / The PI3K–PDK1 connection: more than just a road to PKB by Vanhaesebroeck (2000)
10.1126/science.7701324 / Science / Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor by Yao (1995)
10.1126/science.275.5300.661 / Science / Regulation of neuronal survival by the serine-threonine protein kinase Akt by Dudek (1997)
10.1074/jbc.272.15.9847 / J Biol Chem / Inhibition of phosphatidylinositol 3-kinase activity blocks depolarization- and insulin-like growth factor I-mediated survival of cerebellar granule cells by Miller (1997)
10.1083/jcb.139.3.809 / J Cell Biol / Activated phosphatidylinositol 3-kinase and Akt kinase promote survival of superior cervical neurons by Philpott (1997)
10.1523/JNEUROSCI.18-08-02933.1998 / J Neurosci / Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons by Crowder (1998)
10.1128/MCB.18.4.2143 / Mol Cell Biol / Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line by Eves (1998)
10.1074/jbc.274.32.22569 / J Biol Chem / Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase by Hetman (1999)
10.1083/jcb.146.5.955 / J Cell Biol / Depolarization and neurotrophins converge on the phosphatidylinositol 3-kinase-Akt pathway to synergistically regulate neuronal survival by Vaillant (1999)
10.1016/S0896-6273(00)00061-1 / Neuron / Spatially and functionally distinct roles of the PI3-K effector pathway during NGF signaling in sympathetic neurons by Kuruvilla (2000)
10.1128/MCB.21.3.952-965.2001 / Mol Cell Biol / The protein kinase SGK mediates survival signals by phosphorylating the Forkhead transcription factor FKHRL1/FOXO3a by Brunet (2001)
10.1016/S0960-9822(00)00733-8 / Curr Biol / Identification of CISK, a new member of the SGK kinase family that promotes IL-3-dependent survival by Liu (2000)
10.1016/S1367-5931(99)80067-2 / Curr Opin Chem Biol / The development and therapeutic potential of protein kinase inhibitors by Cohen (1999)
10.1016/S0014-5793(96)01370-1 / FEBS Lett / Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase by Alessi (1996)
10.1101/gad.12.4.502 / Genes Dev / 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt (PKB) signaling pathway by Gingras (1998)
10.1038/21218 / Nature / Regulation of endothelium-derived nitric oxide production by the protein kinase Akt by Fulton (1999)
10.1074/jbc.274.19.13085 / J Biol Chem / Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit by Kang (1999)
10.1074/jbc.274.45.32274 / J Biol Chem / Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-kinase/AKT in breast cancer cells by Altiok (1999)
10.1126/science.286.5445.1741 / Science / Phosphorylation and regulation of Raf by Akt (protein kinase B) by Zimmermann (1999)
10.1038/43466 / Nature / NF-κB activation by tumour necrosis factor requires the Akt serine- threonine kinase by Ozes (1999)
10.1038/43474 / Nature / NF-κB is a target of AKT in anti-apoptotic PDGF signalling by Romashkova (1999)
10.1038/378785a0 / Nature / Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B by Cross (1995)
10.1126/science.278.5341.1319 / Science / daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans by Lin (1997)
10.1038/40194 / Nature / The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans by Ogg (1997)
10.1016/S0092-8674(00)80595-4 / Cell / Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor by Brunet (1999)
10.1038/19328 / Nature / Direct control of the Forkhead transcription factor AFX by protein kinase B by Kops (1999)
10.1073/pnas.96.13.7421 / Proc Natl Acad Sci USA / Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1 by Biggs (1999)
10.1128/MCB.20.24.9138-9148.2000 / Mol Cell Biol / Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1) by Dijkers (2000)
10.1128/MCB.20.23.8969-8982.2000 / Mol Cell Biol / Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN by Nakamura (2000)
10.1016/S0960-9822(00)00728-4 / Curr Biol / Expression of the pro-apoptotic bcl-2 family member bim is regulated by the forkhead transcription factor FKHR-L1 by Dijkers (2000)
10.1016/S0002-9440(10)64557-9 / Am J Pathol / The proapoptotic BH3-only protein bim is expressed in hematopoietic, epithelial, neuronal, and germ cells by O'Reilly (2000)
10.1038/35008115 / Nature / AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1 by Medema (2000)
10.1038/73144 / Nat Med / p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes by Boussiotis (2000)
Yamaguchi A, Tamatani M, Matsuzaki H, Namikawa K, Kiyama H, Vitek MP, Mitsuda N, Tohyama M: Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53. J Biol Chem 2001, in press.This paper demonstrates that p53 acts downstream of Akt in primary hippocampal neurons. In this system, apoptosis can be induced by hypoxia and nitric oxide, and Akt inhibits such apoptosis by downregulating the transcriptional activity of p53. Akt promotes survival in part by preventing the transcription of p53 target death genes, as expression of Akt blocks the induction of the pro-apoptotic Bcl-2 family member BAX. (10.1074/jbc.M008552200)
10.1016/0092-8674(95)90412-3 / Cell / Tumor suppressor p53 is a direct transcriptional activator of the human bax gene by Miyashita (1995)
10.1016/S0896-6273(00)80173-7 / Neuron / BAX is required for neuronal death after trophic factor deprivation and during development by Deckwerth (1996)
10.1083/jcb.151.3.483 / J Cell Biol / Akt regulates cell survival and apoptosis at a postmitochondrial level by Zhou (2000)
10.1126/science.288.5468.1053 / Science / Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis by Oda (2000)
10.1016/S0092-8674(00)00073-8 / Cell / p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53 by Oda (2000)
10.1074/jbc.273.49.32377 / J Biol Chem / CREB is a regulatory target for the protein kinase Akt/PKB by Du (1998)
10.1126/science.286.5443.1358 / Science / Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms by Bonni (1999)
10.1126/science.286.5448.2358 / Science / Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons by Riccio (1999)
10.1523/JNEUROSCI.18-24-10356.1998 / J Neurosci / Nerve growth factor-dependent activation of NF-κB contributes to survival of sympathetic neurons by Maggirwar (1998)
10.1128/MCB.20.8.2687-2695.2000 / Mol Cell Biol / The Rel/NF-κB family directly activates expression of the apoptosis inhibitor Bcl-xL by Chen (2000)
10.1101/gad.13.4.382 / Genes Dev / The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-κB that blocks TNFα-induced apoptosis by Zong (1999)
10.1073/pnas.94.19.10057 / Proc Natl Acad Sci USA / Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-κB control by Chu (1997)
10.1016/S0896-6273(00)81010-7 / Neuron / Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism by Tao (1998)
10.1016/S0092-8674(00)80405-5 / Cell / Akt phosphorylation of BAD couples survival signals to the cell- intrinsic death machinery by Datta (1997)
10.1126/science.278.5338.687 / Science / Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt by del Peso (1997)
10.1016/S1097-2765(00)00006-X / Mol Cell / 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation by Datta (2000)
10.1126/science.282.5392.1318 / Science / Regulation of cell death protease caspase-9 by phosphorylation by Cardone (1998)
10.1006/bbrc.1999.1387 / Biochem Biophys Res Commun / Akt phosphorylation site found in human caspase-9 is absent in mouse caspase-9 by Fujita (1999)
10.1074/jbc.M006160200 / J Biol Chem / Glycogen synthase kinase-3β activity is critical for neuronal death caused by inhibiting phosphatidylinositol 3-kinase or Akt but not for death caused by nerve growth factor withdrawal by Crowder (2000)
10.1523/JNEUROSCI.20-07-02567.2000 / J Neurosci / Role of glycogen synthase kinase-3β in neuronal apoptosis induced by trophic withdrawal by Hetman (2000)
10.1016/S1097-2765(00)00066-6 / Mol Cell / In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability by Rathmell (2000)
10.1073/pnas.090082297 / Proc Natl Acad Sci USA / Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival by Vander Heiden (2000)
10.1128/MCB.19.8.5800 / Mol Cell Biol / Akt/protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria by Kennedy (1999)
10.1074/jbc.271.49.31372 / J Biol Chem / Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation by Kohn (1996)
10.1074/jbc.273.42.27320 / J Biol Chem / Activation of protein kinase B/Akt is sufficient to repress the glucocorticoid and cAMP induction of phosphoenolpyruvate carboxykinase gene by Liao (1998)
10.1074/jbc.273.32.20144 / J Biol Chem / Central role for phosphatidylinositide 3-kinase in the repression of glucose-6-phosphatase gene transcription by insulin by Dickens (1998)
10.1074/jbc.274.29.20281 / J Biol Chem / Regulation of GLUT1 gene transcription by the serine/threonine kinase Akt1 by Barthel (1999)
10.1016/S1097-2765(00)80469-4 / Mol Cell / Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A by Harada (1999)
10.1016/S0960-9822(00)00310-9 / Curr Biol / Rsk1 mediates a MEK-MAP kinase cell survival signal by Shimamura (2000)
10.1016/0896-6273(95)90172-8 / Neuron / Characterization of the signaling interactions that promote the survival and growth of developing retinal ganglion cells in culture by Meyer-Franke (1995)
10.1523/JNEUROSCI.19-06-01940.1999 / J Neurosci / Akt-dependent potentiation of L channels by insulin-like growth factor- 1 is required for neuronal survival by Blair (1999)
10.1126/science.7716515 / Science / Calcium signaling in neurons: molecular mechanisms and cellular consequences by Ghosh (1995)
10.1074/jbc.273.32.19929 / J Biol Chem / Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway by Pap (1998)
10.1016/S0896-6273(01)00238-0 / Neuron / Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis by Putcha (2001)
10.1016/S0896-6273(01)00239-2 / Neuron / Dominant- negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release by Whitfield (2001)

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 2:14 p.m.)
Deposited	5 years, 7 months ago (Jan. 28, 2020, 10:22 a.m.)
Indexed	6 days, 10 hours ago (Aug. 26, 2025, 2:56 a.m.)
Issued	24 years, 3 months ago (June 1, 2001)
Published	24 years, 3 months ago (June 1, 2001)
Published Print	24 years, 3 months ago (June 1, 2001)

Funders 0

None

BibTeX

@article{Brunet_2001, title={Transcription-dependent and -independent control of neuronal survival by the PI3K–Akt signaling pathway}, volume={11}, ISSN={0959-4388}, url={http://dx.doi.org/10.1016/s0959-4388(00)00211-7}, DOI={10.1016/s0959-4388(00)00211-7}, number={3}, journal={Current Opinion in Neurobiology}, publisher={Elsevier BV}, author={Brunet, Anne and Datta, Sandeep Robert and Greenberg, Michael E}, year={2001}, month=jun, pages={297–305} }

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      "volume": "139",
      "author": "Philpott",
      "year": "1997",
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      "volume": "18",
      "author": "Crowder",
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      "author": "Eves",
      "year": "1998",
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      "volume": "274",
      "author": "Hetman",
      "year": "1999",
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      "volume": "146",
      "author": "Vaillant",
      "year": "1999",
      "journal-title": "J Cell Biol"
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      "volume": "27",
      "author": "Kuruvilla",
      "year": "2000",
      "journal-title": "Neuron"
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      "volume": "21",
      "author": "Brunet",
      "year": "2001",
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      "volume": "10",
      "author": "Liu",
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      "article-title": "The development and therapeutic potential of protein kinase inhibitors",
      "volume": "3",
      "author": "Cohen",
      "year": "1999",
      "journal-title": "Curr Opin Chem Biol"
    },
    {
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      "DOI": "10.1016/S0014-5793(96)01370-1",
      "article-title": "Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase",
      "volume": "399",
      "author": "Alessi",
      "year": "1996",
      "journal-title": "FEBS Lett"
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    {
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      "article-title": "4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt (PKB) signaling pathway",
      "volume": "12",
      "author": "Gingras",
      "year": "1998",
      "journal-title": "Genes Dev"
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      "first-page": "597",
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      "author": "Fulton",
      "year": "1999",
      "journal-title": "Nature"
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      "article-title": "Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit",
      "volume": "274",
      "author": "Kang",
      "year": "1999",
      "journal-title": "J Biol Chem"
    },
    {
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      "volume": "274",
      "author": "Altiok",
      "year": "1999",
      "journal-title": "J Biol Chem"
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    {
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      "first-page": "1741",
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      "article-title": "Phosphorylation and regulation of Raf by Akt (protein kinase B)",
      "volume": "286",
      "author": "Zimmermann",
      "year": "1999",
      "journal-title": "Science"
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      "DOI": "10.1038/43466",
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      "volume": "401",
      "author": "Ozes",
      "year": "1999",
      "journal-title": "Nature"
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      "author": "Romashkova",
      "year": "1999",
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      "DOI": "10.1038/378785a0",
      "article-title": "Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B",
      "volume": "378",
      "author": "Cross",
      "year": "1995",
      "journal-title": "Nature"
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    {
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      "article-title": "daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans",
      "volume": "278",
      "author": "Lin",
      "year": "1997",
      "journal-title": "Science"
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      "DOI": "10.1038/40194",
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      "volume": "389",
      "author": "Ogg",
      "year": "1997",
      "journal-title": "Nature"
    },
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      "article-title": "Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor",
      "volume": "96",
      "author": "Brunet",
      "year": "1999",
      "journal-title": "Cell"
    },
    {
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      "first-page": "630",
      "DOI": "10.1038/19328",
      "article-title": "Direct control of the Forkhead transcription factor AFX by protein kinase B",
      "volume": "398",
      "author": "Kops",
      "year": "1999",
      "journal-title": "Nature"
    },
    {
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      "article-title": "Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1",
      "volume": "96",
      "author": "Biggs",
      "year": "1999",
      "journal-title": "Proc Natl Acad Sci USA"
    },
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      "first-page": "9138",
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      "volume": "20",
      "author": "Dijkers",
      "year": "2000",
      "journal-title": "Mol Cell Biol"
    },
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      "volume": "20",
      "author": "Nakamura",
      "year": "2000",
      "journal-title": "Mol Cell Biol"
    },
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      "article-title": "Expression of the pro-apoptotic bcl-2 family member bim is regulated by the forkhead transcription factor FKHR-L1",
      "volume": "10",
      "author": "Dijkers",
      "year": "2000",
      "journal-title": "Curr Biol"
    },
    {
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      "first-page": "449",
      "DOI": "10.1016/S0002-9440(10)64557-9",
      "article-title": "The proapoptotic BH3-only protein bim is expressed in hematopoietic, epithelial, neuronal, and germ cells",
      "volume": "157",
      "author": "O'Reilly",
      "year": "2000",
      "journal-title": "Am J Pathol"
    },
    {
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      "first-page": "782",
      "DOI": "10.1038/35008115",
      "article-title": "AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1",
      "volume": "404",
      "author": "Medema",
      "year": "2000",
      "journal-title": "Nature"
    },
    {
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      "first-page": "290",
      "DOI": "10.1038/73144",
      "article-title": "p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes",
      "volume": "6",
      "author": "Boussiotis",
      "year": "2000",
      "journal-title": "Nat Med"
    },
    {
      "key": "10.1016/S0959-4388(00)00211-7_BIB49",
      "doi-asserted-by": "crossref",
      "unstructured": "Yamaguchi A, Tamatani M, Matsuzaki H, Namikawa K, Kiyama H, Vitek MP, Mitsuda N, Tohyama M: Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53. J Biol Chem 2001, in press.This paper demonstrates that p53 acts downstream of Akt in primary hippocampal neurons. In this system, apoptosis can be induced by hypoxia and nitric oxide, and Akt inhibits such apoptosis by downregulating the transcriptional activity of p53. Akt promotes survival in part by preventing the transcription of p53 target death genes, as expression of Akt blocks the induction of the pro-apoptotic Bcl-2 family member BAX.",
      "DOI": "10.1074/jbc.M008552200"
    },
    {
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      "first-page": "293",
      "DOI": "10.1016/0092-8674(95)90412-3",
      "article-title": "Tumor suppressor p53 is a direct transcriptional activator of the human bax gene",
      "volume": "80",
      "author": "Miyashita",
      "year": "1995",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0959-4388(00)00211-7_BIB51",
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      "first-page": "401",
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      "article-title": "BAX is required for neuronal death after trophic factor deprivation and during development",
      "volume": "17",
      "author": "Deckwerth",
      "year": "1996",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/S0959-4388(00)00211-7_BIB52",
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      "first-page": "483",
      "DOI": "10.1083/jcb.151.3.483",
      "article-title": "Akt regulates cell survival and apoptosis at a postmitochondrial level",
      "volume": "151",
      "author": "Zhou",
      "year": "2000",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "10.1016/S0959-4388(00)00211-7_BIB53",
      "doi-asserted-by": "crossref",
      "first-page": "1053",
      "DOI": "10.1126/science.288.5468.1053",
      "article-title": "Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis",
      "volume": "288",
      "author": "Oda",
      "year": "2000",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0959-4388(00)00211-7_BIB54",
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      "first-page": "849",
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      "article-title": "p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53",
      "volume": "102",
      "author": "Oda",
      "year": "2000",
      "journal-title": "Cell"
    },
    {
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      "first-page": "32377",
      "DOI": "10.1074/jbc.273.49.32377",
      "article-title": "CREB is a regulatory target for the protein kinase Akt/PKB",
      "volume": "273",
      "author": "Du",
      "year": "1998",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "10.1016/S0959-4388(00)00211-7_BIB56",
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      "first-page": "1358",
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      "article-title": "Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms",
      "volume": "286",
      "author": "Bonni",
      "year": "1999",
      "journal-title": "Science"
    },
    {
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      "first-page": "2358",
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      "article-title": "Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons",
      "volume": "286",
      "author": "Riccio",
      "year": "1999",
      "journal-title": "Science"
    },
    {
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      "doi-asserted-by": "crossref",
      "first-page": "10356",
      "DOI": "10.1523/JNEUROSCI.18-24-10356.1998",
      "article-title": "Nerve growth factor-dependent activation of NF-\u03baB contributes to survival of sympathetic neurons",
      "volume": "18",
      "author": "Maggirwar",
      "year": "1998",
      "journal-title": "J Neurosci"
    },
    {
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      "first-page": "2687",
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      "article-title": "The Rel/NF-\u03baB family directly activates expression of the apoptosis inhibitor Bcl-xL",
      "volume": "20",
      "author": "Chen",
      "year": "2000",
      "journal-title": "Mol Cell Biol"
    },
    {
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      "first-page": "382",
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      "article-title": "The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-\u03baB that blocks TNF\u03b1-induced apoptosis",
      "volume": "13",
      "author": "Zong",
      "year": "1999",
      "journal-title": "Genes Dev"
    },
    {
      "key": "10.1016/S0959-4388(00)00211-7_BIB61",
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      "first-page": "10057",
      "DOI": "10.1073/pnas.94.19.10057",
      "article-title": "Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-\u03baB control",
      "volume": "94",
      "author": "Chu",
      "year": "1997",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "10.1016/S0959-4388(00)00211-7_BIB62",
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      "first-page": "709",
      "DOI": "10.1016/S0896-6273(00)81010-7",
      "article-title": "Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism",
      "volume": "20",
      "author": "Tao",
      "year": "1998",
      "journal-title": "Neuron"
    },
    {
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      "first-page": "231",
      "DOI": "10.1016/S0092-8674(00)80405-5",
      "article-title": "Akt phosphorylation of BAD couples survival signals to the cell- intrinsic death machinery",
      "volume": "91",
      "author": "Datta",
      "year": "1997",
      "journal-title": "Cell"
    },
    {
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      "DOI": "10.1126/science.278.5338.687",
      "article-title": "Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt",
      "volume": "278",
      "author": "del Peso",
      "year": "1997",
      "journal-title": "Science"
    },
    {
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      "DOI": "10.1016/S1097-2765(00)00006-X",
      "article-title": "14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation",
      "volume": "6",
      "author": "Datta",
      "year": "2000",
      "journal-title": "Mol Cell"
    },
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      "first-page": "1318",
      "DOI": "10.1126/science.282.5392.1318",
      "article-title": "Regulation of cell death protease caspase-9 by phosphorylation",
      "volume": "282",
      "author": "Cardone",
      "year": "1998",
      "journal-title": "Science"
    },
    {
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      "DOI": "10.1006/bbrc.1999.1387",
      "article-title": "Akt phosphorylation site found in human caspase-9 is absent in mouse caspase-9",
      "volume": "264",
      "author": "Fujita",
      "year": "1999",
      "journal-title": "Biochem Biophys Res Commun"
    },
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      "first-page": "34266",
      "DOI": "10.1074/jbc.M006160200",
      "article-title": "Glycogen synthase kinase-3\u03b2 activity is critical for neuronal death caused by inhibiting phosphatidylinositol 3-kinase or Akt but not for death caused by nerve growth factor withdrawal",
      "volume": "275",
      "author": "Crowder",
      "year": "2000",
      "journal-title": "J Biol Chem"
    },
    {
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      "article-title": "Role of glycogen synthase kinase-3\u03b2 in neuronal apoptosis induced by trophic withdrawal",
      "volume": "20",
      "author": "Hetman",
      "year": "2000",
      "journal-title": "J Neurosci"
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      "volume": "6",
      "author": "Rathmell",
      "year": "2000",
      "journal-title": "Mol Cell"
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