DOI: 10.1016/s0959-437x(99)80005-7. pRb and E2f-1 in mouse development and tumorigenesis

pRb and E2f-1 in mouse development and tumorigenesis

10.1016/s0959-437x(99)80005-7

Crossref journal-article

Elsevier BV

Current Opinion in Genetics & Development (78)

Bibliography

Macleod, K. (1999). pRb and E2f-1 in mouse development and tumorigenesis. Current Opinion in Genetics & Development, 9(1), 31â39.

Authors 1

Kay Macleod (first)

References 64 Referenced 55

10.1101/gad.12.15.2245 / Genes Dev / The regulation of E2F by pRB-family members by Dyson (1998)
10.1016/S0168-9525(98)01470-X / Trends Genet / The retinoblastoma gene family: cousins with overlapping interests by Mulligan (1998)
10.1038/36038 / Nature / Structure of the retinoblastoma tumor-suppressor pocket domain bound to a peptide from HPV E7 by Lee (1998)
10.1038/37507 / Nature / An E2F-like repressor of transcription by Morkel (1997)
10.1073/pnas.95.6.2850 / Proc Natl Acad Sci USA / E2F-6, a member of the E2F family that can behave as a transcriptional repressor by Trimarchi (1998)
10.1073/pnas.95.16.9190 / Proc Natl Acad Sci USA / Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6 by Gaubatz (1998)
10.1101/gad.11.15.1987 / Genes Dev / PPARγ induces cell cycle withdrawal: inhibition of E2F/DP DNA-binding activity via down-regulation of PP2A by Altiok (1997)
10.1128/MCB.17.12.7268 / Mol Cell Biol / E2F activity is regulated by cell cycle-dependent changes in subcellular localisation by Verona (1997)
10.1101/gad.10.23.2949 / Genes Dev / The retinoblastoma gene product protects E2F-1 from degradation by the ubiqutin-proteasome pathway by Hofmann (1996)
10.1101/gad.10.23.2960 / Genes Dev / Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins by Hateboer (1996)
10.1038/35404 / Nature / Retinoblastoma protein recruits histone deacetylase to repress transcription by Brehm (1998)
10.1038/35410 / Nature / Retinoblastoma protein represses transcription by recruiting a histone deacetylase by Magnaghi-Jaulin (1998)
10.1016/S0092-8674(00)80940-X / Cell / Rb interacts with histone deacetylase to repress transcription by Luo (1998)
10.1073/pnas.94.14.7245 / Proc Natl Acad Sci USA / Distinct roles for E2F proteins in cell growth control and apoptosis by DeGregori (1997)
{'key': '10.1016/S0959-437X(99)80005-7_BIB15', 'first-page': '113', 'article-title': 'E2F-1 specific induction of apoptosis and p53 accumulation which is blocked by mdm2', 'volume': '9', 'author': 'Kowalik', 'year': '1998', 'journal-title': 'Cell Growth Diff'} / Cell Growth Diff / E2F-1 specific induction of apoptosis and p53 accumulation which is blocked by mdm2 by Kowalik (1998)
10.1101/gad.11.11.1447 / Genes Dev / pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes by Hurford (1997)
10.1038/359295a0 / Nature / Effects of an Rb mutation in the mouse by Jacks (1992)
10.1038/359288a0 / Nature / Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis by Lee (1992)
10.1038/359328a0 / Nature / Requirement for a functional Rb-1 gene in murine development by Clarke (1992)
10.1101/gad.8.17.2008 / Genes Dev / Dual Roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation by Lee (1994)
10.1038/371072a0 / Nature / p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens by Morgenbesser (1994)
10.1002/j.1460-2075.1996.tb01006.x / EMBO J / Loss of Rb activates both p53-dependent and -independent cell death pathways in the developing mouse nervous system by Macleod (1996)
10.1101/gad.10.13.1621 / Genes Dev / Targeted disruption of p107: functional overlap between p107 and Rb by Lee (1996)
10.1101/gad.10.13.1633 / Genes Dev / Shared role of the pRB-related p130 and p107 proteins in limb development by Cobrinik (1996)
10.1038/sj.onc.1201014 / Oncogene / The retinoblastoma gene family is differentially expressed during embryogenesis by Jiang (1997)
10.1101/gad.10.23.3051 / Genes Dev / pRb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis by Zacksenhaus (1996)
10.1016/S0092-8674(00)81254-4 / Cell / Tumor induction and tissue atrophy in mice lacking E2F-1 by Yamasaki (1996)
10.1016/S0092-8674(00)81255-6 / Cell / E2F-1 functions in mice to promote apoptosis and suppress proliferation by Field (1996)
10.1101/gad.10.15.1870 / Genes Dev / Early loss of the retinoblastoma gene is associated with impaired growth inhibitory innervation during melanotroph carcinogenesis in Rb+/– mice by Nikitin (1996)
10.1101/gad.8.11.1285 / Genes Dev / Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development by Pan (1994)
10.1101/gad.9.17.2157 / Genes Dev / Temporally distinct patterns of p53-dependent and p53-independent apoptosis during mouse lens development by Pan (1995)
10.1101/gad.8.11.1300 / Genes Dev / Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53 by Howes (1994)
10.1016/0092-8674(94)90534-7 / Cell / p53-dependent apoptosis suppresses tumor growth and progression in vivo by Symonds (1994)
10.1073/pnas.91.26.12823 / Proc Natl Acad Sci USA / Oncogenic capacity of the E2F-1 gene by Johnson (1994)
10.1128/MCB.16.2.685 / Mol Cell Biol / E2F-1 blocks terminal differentiation and causes proliferation in transgenic megakaryocytes by Guy (1996)
10.1038/sj.onc.1202169 / Oncogene / Flp-mediated tissue specific inactivation of the retinoblastoma tumor suppressor gene in the mouse by Vooijs (1998)
10.1073/pnas.95.15.8858 / Proc Natl Acad Sci USA / Increased E2F-1 activity induces skin tumors in mice heterozygous and nullizygous for p53 by Pierce (1998)
10.1038/sj.onc.1201666 / Oncogene / Deregulated expression of E2F-1 induces hyperplasia and cooperates with ras in skin tumor development by Pierce (1998)
10.1038/ng0498-360 / Nat Genet / Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1+/– mice by Yamasaki (1998)
10.1016/S1097-2765(00)80273-7 / Mol Cell / A key role for E2F-1 in p53-dependent apoptosis and cell division within developing tumors by Pan (1998)
10.1016/S1097-2765(00)80274-9 / Mol Cell / Mutation of E2f-1 suppresses apoptosis and inappropriate S-phase entry and extends survival of Rb-deficient mouse embryos by Tsai (1998)
10.1016/S0168-9525(98)01520-0 / Trends Genet / Traps to catch unwary oncogenes by Hueber (1998)
10.1016/S0092-8674(00)81401-4 / Cell / ARF promotes mdm2 degradation and stabilises p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways by Zhang (1998)
10.1016/S0092-8674(00)81400-2 / Cell / The Ink4a tumor suppressor gene product p19ARF interacts with mdm2 and neutralises mdm2’s inhibition of p53 by Pomerantz (1998)
10.1073/pnas.95.14.8292 / Proc Natl Acad Sci USA / Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2 by Kamijo (1998)
10.1101/gad.12.15.2434 / Genes Dev / E1A signalling to p53 involves the 19ARF tumor suppressor by de Stanchina (1998)
10.1101/gad.12.15.2424 / Genes Dev / Myc signalling via the ARF tumor suppressor regulates p53-dependent apoptosis by Zindy (1998)
10.1038/25870 / Nature / p19ARF links the tumor suppressor p53 to Ras by Palmero (1998)
10.1038/25867 / Nature / p14ARF links the tumor suppressors RB and p53 by Bates (1998)
10.1101/gad.12.14.2120 / Genes Dev / E2F3 activity is regulated during the cell cycle and is required for the induction of S phase by Leone (1998)
10.1101/gad.11.14.1840 / Genes Dev / E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction by Hsieh (1997)
10.1101/gad.11.14.1853 / Genes Dev / Induction of DNA synthesis and apoptosis are separable functions of E2F-1 by Phillips (1997)
10.1101/gad.12.20.3162 / Genes Dev / Cooperation between the cdk inhibitors p27KIP1 and p57KIP2 in the control of tissue growth and development by Zhang (1998)
10.1002/j.1460-2075.1996.tb01089.x / EMBO J / Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis by Janicke (1996)
10.1002/j.1460-2075.1994.tb06746.x / EMBO J / Developmental rescue of an embryonic-lethal mutation in the retinoblastoma gene in chimeric mice by Robanus-Maandag (1994)
10.1002/j.1460-2075.1994.tb06745.x / EMBO J / Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences by Williams (1994)
10.1101/gad.10.21.2794 / Genes Dev / Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interactions with C/EBPs by Chen (1996)
10.1016/0092-8674(93)90110-C / Cell / Interaction of myogenic factors and the retinblastoma protein mediates muscle cell commitment and differentiation by Gu (1993)
10.1126/science.8197461 / Science / Reversal of terminal differentiation mediated by p107 in Rb–/– muscle cells by Schneider (1994)
10.1083/jcb.135.2.441 / J Cell Biol / Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S phase and G2 phases of the cell cycle by Novitch (1996)
10.1101/gad.12.1.95 / Genes Dev / Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation and suppress tumor cell growth by Sellers (1998)
10.1073/pnas.94.22.12094 / Proc Natl Acad Sci USA / Selective induction of p53 and chemosensitivity in RB-deficient cells by E1a mutants unable to bind the RB-related proteins by Samuelson (1997)
10.1101/gad.12.11.1599 / Genes Dev / p107 is a suppressor of retinoblastoma development in Rb-deficient mice by Robanus-Maandag (1998)
10.1016/S0968-0004(96)10067-0 / Trends Biochem Sci / Regulation of RNA polymerases I and III by the retinoblastoma protein: a mechanism for growth control? by White (1997)

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 3:06 p.m.)
Deposited	5 years, 7 months ago (Jan. 14, 2020, 8:26 p.m.)
Indexed	2 weeks, 6 days ago (Aug. 5, 2025, 9:06 a.m.)
Issued	26 years, 6 months ago (Feb. 1, 1999)
Published	26 years, 6 months ago (Feb. 1, 1999)
Published Print	26 years, 6 months ago (Feb. 1, 1999)

Funders 0

None

BibTeX

@article{Macleod_1999, title={pRb and E2f-1 in mouse development and tumorigenesis}, volume={9}, ISSN={0959-437X}, url={http://dx.doi.org/10.1016/s0959-437x(99)80005-7}, DOI={10.1016/s0959-437x(99)80005-7}, number={1}, journal={Current Opinion in Genetics & Development}, publisher={Elsevier BV}, author={Macleod, Kay}, year={1999}, month=feb, pages={31–39} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        5
      ]
    ],
    "date-time": "2025-08-05T13:06:01Z",
    "timestamp": 1754399161720
  },
  "reference-count": 64,
  "publisher": "Elsevier BV",
  "issue": "1",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1999,
            2,
            1
          ]
        ],
        "date-time": "1999-02-01T00:00:00Z",
        "timestamp": 917827200000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1999,
        2
      ]
    ]
  },
  "DOI": "10.1016/s0959-437x(99)80005-7",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        7,
        25
      ]
    ],
    "date-time": "2002-07-25T19:06:41Z",
    "timestamp": 1027624001000
  },
  "page": "31-39",
  "source": "Crossref",
  "is-referenced-by-count": 55,
  "title": "pRb and E2f-1 in mouse development and tumorigenesis",
  "prefix": "10.1016",
  "volume": "9",
  "author": [
    {
      "given": "Kay",
      "family": "Macleod",
      "sequence": "first",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB1",
      "doi-asserted-by": "crossref",
      "first-page": "2245",
      "DOI": "10.1101/gad.12.15.2245",
      "article-title": "The regulation of E2F by pRB-family members",
      "volume": "12",
      "author": "Dyson",
      "year": "1998",
      "journal-title": "Genes Dev"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "223",
      "DOI": "10.1016/S0168-9525(98)01470-X",
      "article-title": "The retinoblastoma gene family: cousins with overlapping interests",
      "volume": "14",
      "author": "Mulligan",
      "year": "1998",
      "journal-title": "Trends Genet"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "859",
      "DOI": "10.1038/36038",
      "article-title": "Structure of the retinoblastoma tumor-suppressor pocket domain bound to a peptide from HPV E7",
      "volume": "391",
      "author": "Lee",
      "year": "1998",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB4",
      "doi-asserted-by": "crossref",
      "first-page": "567",
      "DOI": "10.1038/37507",
      "article-title": "An E2F-like repressor of transcription",
      "volume": "390",
      "author": "Morkel",
      "year": "1997",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB5",
      "doi-asserted-by": "crossref",
      "first-page": "2850",
      "DOI": "10.1073/pnas.95.6.2850",
      "article-title": "E2F-6, a member of the E2F family that can behave as a transcriptional repressor",
      "volume": "95",
      "author": "Trimarchi",
      "year": "1998",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "9190",
      "DOI": "10.1073/pnas.95.16.9190",
      "article-title": "Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6",
      "volume": "95",
      "author": "Gaubatz",
      "year": "1998",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "1987",
      "DOI": "10.1101/gad.11.15.1987",
      "article-title": "PPAR\u03b3 induces cell cycle withdrawal: inhibition of E2F/DP DNA-binding activity via down-regulation of PP2A",
      "volume": "11",
      "author": "Altiok",
      "year": "1997",
      "journal-title": "Genes Dev"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB8",
      "doi-asserted-by": "crossref",
      "first-page": "7268",
      "DOI": "10.1128/MCB.17.12.7268",
      "article-title": "E2F activity is regulated by cell cycle-dependent changes in subcellular localisation",
      "volume": "17",
      "author": "Verona",
      "year": "1997",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "2949",
      "DOI": "10.1101/gad.10.23.2949",
      "article-title": "The retinoblastoma gene product protects E2F-1 from degradation by the ubiqutin-proteasome pathway",
      "volume": "10",
      "author": "Hofmann",
      "year": "1996",
      "journal-title": "Genes Dev"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "2960",
      "DOI": "10.1101/gad.10.23.2960",
      "article-title": "Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins",
      "volume": "10",
      "author": "Hateboer",
      "year": "1996",
      "journal-title": "Genes Dev"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB11",
      "doi-asserted-by": "crossref",
      "first-page": "597",
      "DOI": "10.1038/35404",
      "article-title": "Retinoblastoma protein recruits histone deacetylase to repress transcription",
      "volume": "391",
      "author": "Brehm",
      "year": "1998",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "601",
      "DOI": "10.1038/35410",
      "article-title": "Retinoblastoma protein represses transcription by recruiting a histone deacetylase",
      "volume": "391",
      "author": "Magnaghi-Jaulin",
      "year": "1998",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "463",
      "DOI": "10.1016/S0092-8674(00)80940-X",
      "article-title": "Rb interacts with histone deacetylase to repress transcription",
      "volume": "92",
      "author": "Luo",
      "year": "1998",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "7245",
      "DOI": "10.1073/pnas.94.14.7245",
      "article-title": "Distinct roles for E2F proteins in cell growth control and apoptosis",
      "volume": "94",
      "author": "DeGregori",
      "year": "1997",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB15",
      "first-page": "113",
      "article-title": "E2F-1 specific induction of apoptosis and p53 accumulation which is blocked by mdm2",
      "volume": "9",
      "author": "Kowalik",
      "year": "1998",
      "journal-title": "Cell Growth Diff"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "1447",
      "DOI": "10.1101/gad.11.11.1447",
      "article-title": "pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes",
      "volume": "11",
      "author": "Hurford",
      "year": "1997",
      "journal-title": "Genes Dev"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "295",
      "DOI": "10.1038/359295a0",
      "article-title": "Effects of an Rb mutation in the mouse",
      "volume": "359",
      "author": "Jacks",
      "year": "1992",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "288",
      "DOI": "10.1038/359288a0",
      "article-title": "Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis",
      "volume": "359",
      "author": "Lee",
      "year": "1992",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "328",
      "DOI": "10.1038/359328a0",
      "article-title": "Requirement for a functional Rb-1 gene in murine development",
      "volume": "359",
      "author": "Clarke",
      "year": "1992",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "2008",
      "DOI": "10.1101/gad.8.17.2008",
      "article-title": "Dual Roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation",
      "volume": "8",
      "author": "Lee",
      "year": "1994",
      "journal-title": "Genes Dev"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB21",
      "doi-asserted-by": "crossref",
      "first-page": "72",
      "DOI": "10.1038/371072a0",
      "article-title": "p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens",
      "volume": "371",
      "author": "Morgenbesser",
      "year": "1994",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "6178",
      "DOI": "10.1002/j.1460-2075.1996.tb01006.x",
      "article-title": "Loss of Rb activates both p53-dependent and -independent cell death pathways in the developing mouse nervous system",
      "volume": "15",
      "author": "Macleod",
      "year": "1996",
      "journal-title": "EMBO J"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "1621",
      "DOI": "10.1101/gad.10.13.1621",
      "article-title": "Targeted disruption of p107: functional overlap between p107 and Rb",
      "volume": "10",
      "author": "Lee",
      "year": "1996",
      "journal-title": "Genes Dev"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "1633",
      "DOI": "10.1101/gad.10.13.1633",
      "article-title": "Shared role of the pRB-related p130 and p107 proteins in limb development",
      "volume": "10",
      "author": "Cobrinik",
      "year": "1996",
      "journal-title": "Genes Dev"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "1789",
      "DOI": "10.1038/sj.onc.1201014",
      "article-title": "The retinoblastoma gene family is differentially expressed during embryogenesis",
      "volume": "14",
      "author": "Jiang",
      "year": "1997",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB26",
      "doi-asserted-by": "crossref",
      "first-page": "3051",
      "DOI": "10.1101/gad.10.23.3051",
      "article-title": "pRb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis",
      "volume": "10",
      "author": "Zacksenhaus",
      "year": "1996",
      "journal-title": "Genes Dev"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB27",
      "doi-asserted-by": "crossref",
      "first-page": "537",
      "DOI": "10.1016/S0092-8674(00)81254-4",
      "article-title": "Tumor induction and tissue atrophy in mice lacking E2F-1",
      "volume": "85",
      "author": "Yamasaki",
      "year": "1996",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "549",
      "DOI": "10.1016/S0092-8674(00)81255-6",
      "article-title": "E2F-1 functions in mice to promote apoptosis and suppress proliferation",
      "volume": "85",
      "author": "Field",
      "year": "1996",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "1870",
      "DOI": "10.1101/gad.10.15.1870",
      "article-title": "Early loss of the retinoblastoma gene is associated with impaired growth inhibitory innervation during melanotroph carcinogenesis in Rb+/\u2013 mice",
      "volume": "10",
      "author": "Nikitin",
      "year": "1996",
      "journal-title": "Genes Dev"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "1285",
      "DOI": "10.1101/gad.8.11.1285",
      "article-title": "Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development",
      "volume": "8",
      "author": "Pan",
      "year": "1994",
      "journal-title": "Genes Dev"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "2157",
      "DOI": "10.1101/gad.9.17.2157",
      "article-title": "Temporally distinct patterns of p53-dependent and p53-independent apoptosis during mouse lens development",
      "volume": "9",
      "author": "Pan",
      "year": "1995",
      "journal-title": "Genes Dev"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "1300",
      "DOI": "10.1101/gad.8.11.1300",
      "article-title": "Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53",
      "volume": "8",
      "author": "Howes",
      "year": "1994",
      "journal-title": "Genes Dev"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "703",
      "DOI": "10.1016/0092-8674(94)90534-7",
      "article-title": "p53-dependent apoptosis suppresses tumor growth and progression in vivo",
      "volume": "78",
      "author": "Symonds",
      "year": "1994",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "12823",
      "DOI": "10.1073/pnas.91.26.12823",
      "article-title": "Oncogenic capacity of the E2F-1 gene",
      "volume": "91",
      "author": "Johnson",
      "year": "1994",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "685",
      "DOI": "10.1128/MCB.16.2.685",
      "article-title": "E2F-1 blocks terminal differentiation and causes proliferation in transgenic megakaryocytes",
      "volume": "16",
      "author": "Guy",
      "year": "1996",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB36",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1038/sj.onc.1202169",
      "article-title": "Flp-mediated tissue specific inactivation of the retinoblastoma tumor suppressor gene in the mouse",
      "volume": "17",
      "author": "Vooijs",
      "year": "1998",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB37",
      "doi-asserted-by": "crossref",
      "first-page": "8858",
      "DOI": "10.1073/pnas.95.15.8858",
      "article-title": "Increased E2F-1 activity induces skin tumors in mice heterozygous and nullizygous for p53",
      "volume": "95",
      "author": "Pierce",
      "year": "1998",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB38",
      "doi-asserted-by": "crossref",
      "first-page": "1267",
      "DOI": "10.1038/sj.onc.1201666",
      "article-title": "Deregulated expression of E2F-1 induces hyperplasia and cooperates with ras in skin tumor development",
      "volume": "16",
      "author": "Pierce",
      "year": "1998",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB39",
      "doi-asserted-by": "crossref",
      "first-page": "360",
      "DOI": "10.1038/ng0498-360",
      "article-title": "Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1+/\u2013 mice",
      "volume": "18",
      "author": "Yamasaki",
      "year": "1998",
      "journal-title": "Nat Genet"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "293",
      "DOI": "10.1016/S1097-2765(00)80273-7",
      "article-title": "A key role for E2F-1 in p53-dependent apoptosis and cell division within developing tumors",
      "volume": "2",
      "author": "Pan",
      "year": "1998",
      "journal-title": "Mol Cell"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB41",
      "doi-asserted-by": "crossref",
      "first-page": "283",
      "DOI": "10.1016/S1097-2765(00)80274-9",
      "article-title": "Mutation of E2f-1 suppresses apoptosis and inappropriate S-phase entry and extends survival of Rb-deficient mouse embryos",
      "volume": "2",
      "author": "Tsai",
      "year": "1998",
      "journal-title": "Mol Cell"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB42",
      "doi-asserted-by": "crossref",
      "first-page": "364",
      "DOI": "10.1016/S0168-9525(98)01520-0",
      "article-title": "Traps to catch unwary oncogenes",
      "volume": "14",
      "author": "Hueber",
      "year": "1998",
      "journal-title": "Trends Genet"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB43",
      "doi-asserted-by": "crossref",
      "first-page": "725",
      "DOI": "10.1016/S0092-8674(00)81401-4",
      "article-title": "ARF promotes mdm2 degradation and stabilises p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways",
      "volume": "92",
      "author": "Zhang",
      "year": "1998",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB44",
      "doi-asserted-by": "crossref",
      "first-page": "713",
      "DOI": "10.1016/S0092-8674(00)81400-2",
      "article-title": "The Ink4a tumor suppressor gene product p19ARF interacts with mdm2 and neutralises mdm2\u2019s inhibition of p53",
      "volume": "92",
      "author": "Pomerantz",
      "year": "1998",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB45",
      "doi-asserted-by": "crossref",
      "first-page": "8292",
      "DOI": "10.1073/pnas.95.14.8292",
      "article-title": "Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2",
      "volume": "95",
      "author": "Kamijo",
      "year": "1998",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB46",
      "doi-asserted-by": "crossref",
      "first-page": "2434",
      "DOI": "10.1101/gad.12.15.2434",
      "article-title": "E1A signalling to p53 involves the 19ARF tumor suppressor",
      "volume": "12",
      "author": "de Stanchina",
      "year": "1998",
      "journal-title": "Genes Dev"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB47",
      "doi-asserted-by": "crossref",
      "first-page": "2424",
      "DOI": "10.1101/gad.12.15.2424",
      "article-title": "Myc signalling via the ARF tumor suppressor regulates p53-dependent apoptosis",
      "volume": "12",
      "author": "Zindy",
      "year": "1998",
      "journal-title": "Genes Dev"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB48",
      "doi-asserted-by": "crossref",
      "first-page": "125",
      "DOI": "10.1038/25870",
      "article-title": "p19ARF links the tumor suppressor p53 to Ras",
      "volume": "395",
      "author": "Palmero",
      "year": "1998",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB49",
      "doi-asserted-by": "crossref",
      "first-page": "124",
      "DOI": "10.1038/25867",
      "article-title": "p14ARF links the tumor suppressors RB and p53",
      "volume": "395",
      "author": "Bates",
      "year": "1998",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB50",
      "doi-asserted-by": "crossref",
      "first-page": "2120",
      "DOI": "10.1101/gad.12.14.2120",
      "article-title": "E2F3 activity is regulated during the cell cycle and is required for the induction of S phase",
      "volume": "12",
      "author": "Leone",
      "year": "1998",
      "journal-title": "Genes Dev"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB51",
      "doi-asserted-by": "crossref",
      "first-page": "1840",
      "DOI": "10.1101/gad.11.14.1840",
      "article-title": "E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction",
      "volume": "11",
      "author": "Hsieh",
      "year": "1997",
      "journal-title": "Genes Dev"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB52",
      "doi-asserted-by": "crossref",
      "first-page": "1853",
      "DOI": "10.1101/gad.11.14.1853",
      "article-title": "Induction of DNA synthesis and apoptosis are separable functions of E2F-1",
      "volume": "11",
      "author": "Phillips",
      "year": "1997",
      "journal-title": "Genes Dev"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB53",
      "doi-asserted-by": "crossref",
      "first-page": "3162",
      "DOI": "10.1101/gad.12.20.3162",
      "article-title": "Cooperation between the cdk inhibitors p27KIP1 and p57KIP2 in the control of tissue growth and development",
      "volume": "12",
      "author": "Zhang",
      "year": "1998",
      "journal-title": "Genes Dev"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB54",
      "doi-asserted-by": "crossref",
      "first-page": "6969",
      "DOI": "10.1002/j.1460-2075.1996.tb01089.x",
      "article-title": "Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis",
      "volume": "15",
      "author": "Janicke",
      "year": "1996",
      "journal-title": "EMBO J"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB55",
      "doi-asserted-by": "crossref",
      "first-page": "4260",
      "DOI": "10.1002/j.1460-2075.1994.tb06746.x",
      "article-title": "Developmental rescue of an embryonic-lethal mutation in the retinoblastoma gene in chimeric mice",
      "volume": "13",
      "author": "Robanus-Maandag",
      "year": "1994",
      "journal-title": "EMBO J"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB56",
      "doi-asserted-by": "crossref",
      "first-page": "4251",
      "DOI": "10.1002/j.1460-2075.1994.tb06745.x",
      "article-title": "Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences",
      "volume": "13",
      "author": "Williams",
      "year": "1994",
      "journal-title": "EMBO J"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB57",
      "doi-asserted-by": "crossref",
      "first-page": "2794",
      "DOI": "10.1101/gad.10.21.2794",
      "article-title": "Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interactions with C/EBPs",
      "volume": "10",
      "author": "Chen",
      "year": "1996",
      "journal-title": "Genes Dev"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB58",
      "doi-asserted-by": "crossref",
      "first-page": "309",
      "DOI": "10.1016/0092-8674(93)90110-C",
      "article-title": "Interaction of myogenic factors and the retinblastoma protein mediates muscle cell commitment and differentiation",
      "volume": "72",
      "author": "Gu",
      "year": "1993",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB59",
      "doi-asserted-by": "crossref",
      "first-page": "1467",
      "DOI": "10.1126/science.8197461",
      "article-title": "Reversal of terminal differentiation mediated by p107 in Rb\u2013/\u2013 muscle cells",
      "volume": "264",
      "author": "Schneider",
      "year": "1994",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB60",
      "doi-asserted-by": "crossref",
      "first-page": "441",
      "DOI": "10.1083/jcb.135.2.441",
      "article-title": "Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S phase and G2 phases of the cell cycle",
      "volume": "135",
      "author": "Novitch",
      "year": "1996",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB61",
      "doi-asserted-by": "crossref",
      "first-page": "95",
      "DOI": "10.1101/gad.12.1.95",
      "article-title": "Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation and suppress tumor cell growth",
      "volume": "12",
      "author": "Sellers",
      "year": "1998",
      "journal-title": "Genes Dev"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB62",
      "doi-asserted-by": "crossref",
      "first-page": "12094",
      "DOI": "10.1073/pnas.94.22.12094",
      "article-title": "Selective induction of p53 and chemosensitivity in RB-deficient cells by E1a mutants unable to bind the RB-related proteins",
      "volume": "94",
      "author": "Samuelson",
      "year": "1997",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB63",
      "doi-asserted-by": "crossref",
      "first-page": "1599",
      "DOI": "10.1101/gad.12.11.1599",
      "article-title": "p107 is a suppressor of retinoblastoma development in Rb-deficient mice",
      "volume": "12",
      "author": "Robanus-Maandag",
      "year": "1998",
      "journal-title": "Genes Dev"
    },
    {
      "key": "10.1016/S0959-437X(99)80005-7_BIB64",
      "doi-asserted-by": "crossref",
      "first-page": "77",
      "DOI": "10.1016/S0968-0004(96)10067-0",
      "article-title": "Regulation of RNA polymerases I and III by the retinoblastoma protein: a mechanism for growth control?",
      "volume": "22",
      "author": "White",
      "year": "1997",
      "journal-title": "Trends Biochem Sci"
    }
  ],
  "container-title": "Current Opinion in Genetics &amp; Development",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0959437X99800057?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0959437X99800057?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2020,
        1,
        15
      ]
    ],
    "date-time": "2020-01-15T01:26:11Z",
    "timestamp": 1579051571000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0959437X99800057"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1999,
        2
      ]
    ]
  },
  "references-count": 64,
  "journal-issue": {
    "issue": "1",
    "published-print": {
      "date-parts": [
        [
          1999,
          2
        ]
      ]
    }
  },
  "alternative-id": [
    "S0959437X99800057"
  ],
  "URL": "http://dx.doi.org/10.1016/S0959-437X(99)80005-7",
  "relation": {},
  "ISSN": [
    "0959-437X"
  ],
  "subject": [],
  "container-title-short": "Current Opinion in Genetics &amp; Development",
  "published": {
    "date-parts": [
      [
        1999,
        2
      ]
    ]
  }
}