Crossref journal-article
Elsevier BV
Current Opinion in Genetics & Development (78)
Bibliography

Lansbury, P. T., & Brice, A. (2002). Genetics of Parkinson’s disease and biochemical studies of implicated gene products. Current Opinion in Genetics & Development, 12(3), 299–306.

Authors 2
  1. Peter T Lansbury (first)
  2. Alexis Brice (additional)
References 80 Referenced 54
  1. 10.1016/S0092-8674(00)80629-7 / Cell / New animal models for Parkinson's disease by Dawson (2000)
  2. 10.1001/jama.284.15.1931 / J Am Med Assoc / Pramipexole vs levodopa as initial treatment for Parkinson disease: a randomized controlled trial (2000)
  3. 10.1126/science.276.5321.2045 / Science / Mutation in the alpha-synuclein gene identified in families with Parkinson's disease by Polymeropoulos (1997)
  4. 10.1002/mds.1221 / Mov Disord / Clinical features of parkinsonian patients with the alpha-synuclein (G209A) mutation. Mov patients with the alpha-synuclein (G209A) mutation by Bostantjopoulou (2001)
  5. 10.1136/jnnp.70.5.662 / J Neurol Neurosurg Psychiatry / Clinical phenotype in patients with alpha-synuclein Parkinson's disease living in Greece in comparison with patients with sporadic Parkinson's disease by Papapetropoulos (2001)
  6. 10.1002/ana.67 / Ann Neurol / Clinical and pathological features of a Parkinsonian syndrome in a family with an Ala53Thr alpha-synuclein mutation by Spira (2001)
  7. 10.1038/ng0298-106 / Nat Genet / Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease by Kruger (1998)
  8. 10.1002/ana.1027 / Ann Neurol / Parkinson's disease is not associated with the combined alpha-synuclein/apolipoprotein E susceptibility genotype by Khan (2001)
  9. 10.1016/S0304-3940(01)01557-9 / Neurosci Lett / Genetic studies in Parkinson's disease with an alpha-synuclein/NACP gene polymorphism in Japan by Izumi (2001)
  10. 10.1093/hmg/10.17.1847 / Hum Mol Genet / alpha-Synuclein gene haplotypes are associated with Parkinson's disease by Farrer (2001)
  11. 10.1073/pnas.97.2.571 / Proc Natl Acad Sci USA / Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy by Conway (2000)
  12. 10.1074/jbc.C100551200 / J Biol Chem / Stabilization of partially folded conformation during alpha-synuclein oligomerization in both purified and cytosolic preparations by Uversky (2001)
  13. 10.1074/jbc.M010907200 / J Biol Chem / Evidence for a partially folded intermediate in alpha-synuclein fibril formation by Uversky (2001)
  14. 10.1006/jmbi.2001.4538 / J Mol Biol / Conformational properties of alpha-synuclein in its free and lipid-associated states by Eliezer (2001)
  15. 10.1021/bi0102398 / Biochemistry / Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease by Volles (2001)
  16. 10.1074/jbc.M008919200 / J Biol Chem / A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly by Giasson (2001)
  17. 10.1074/jbc.M105343200 / J Biol Chem / Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure by Uversky (2001)
  18. 10.1016/S0014-5793(01)02597-2 / FEBS Lett / Pesticides directly accelerate the rate of alpha-synuclein fibril formation: a possible factor in Parkinson's disease by Uversky (2001)
  19. 10.1073/pnas.171300598 / Proc Natl Acad Sci USA / alpha-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins by Sharon (2001)
  20. 10.1096/fj.00-0334com / FASEB J / Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis by Lee (2001)
  21. 10.1074/jbc.M108414200 / J Biol Chem / Lipid droplet binding and oligomerization properties of the Parkinson's disease protein alpha-synuclein by Cole (2002)
  22. 10.1021/bi002952n / Biochemistry / Membrane binding and self-association of alpha-synucleins by Narayanan (2001)
  23. 10.1074/jbc.M105022200 / J Biol Chem / Exposure to long chain polyunsaturated fatty acids triggers rapid multimerization of synucleins by Perrin (2001)
  24. 10.1126/science.1060627 / Science / Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease by Shimura (2001)
  25. 10.1074/jbc.M103766200 / J Biol Chem / Tetrahydrobiopterin scavenges superoxide in dopaminergic neurons by Nakamura (2001)
  26. 10.1074/jbc.M010316200 / J Biol Chem / alpha-synuclein is phosphorylated by members of the Src family of protein-tyrosine kinases by Ellis (2001)
  27. 10.1046/j.1471-4159.2001.00174.x / J Neurochem / Oxidative post-translational modifications of alpha-synuclein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease by Przedborski (2001)
  28. 10.1126/science.1063522 / Science / Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct by Conway (2001)
  29. 10.1016/S0006-8993(01)02772-X / Brain Res / Altered expression of the synuclein family mRNA in Lewy body and Alzheimer's disease by Rockenstein (2001)
  30. 10.1016/S0896-6273(01)00462-7 / Neuron / beta-Synuclein inhibits alpha-synuclein aggregation: a possible role as an anti-parkinsonian factor by Hashimoto (2001)
  31. 10.1016/S0169-328X(01)00257-1 / Brain Res Mol Brain Res / Protein-protein interactions of alpha-synuclein in brain homogenates and transfected cells by Payton (2001)
  32. 10.1046/j.1471-4159.2001.00301.x / J Neurochem / Interaction of alpha-synuclein and synphilin-1: effect of Parkinson's disease-associated mutations by Kawamata (2001)
  33. 10.1096/fj.00-0334com / FASEB J / Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis by Lee (2001)
  34. 10.1002/1531-8249(20010201)49:2<276::AID-ANA54>3.0.CO;2-2 / Ann Neurol / No evidence of association between a dopamine transporter gene polymorphism (1215A/G) and Parkinson's disease by Kimura (2001)
  35. 10.1006/nbdi.2000.0326 / Neurobiol Dis / Genetic analysis of synphilin-1 in familial Parkinson's disease by Farrer (2001)
  36. 10.1046/j.1471-4159.2001.00655.x / J Neurochem / Cytosolic O-glycosylation is abundant in nerve terminals by Cole (2001)
  37. 10.1523/JNEUROSCI.21-24-09549.2001 / J Neurosci / Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death by Stefanis (2001)
  38. 10.1101/gr.165801 / Genome Res / Human and mouse alpha-synuclein genes: comparative genomic sequence analysis and identification of a novel gene regulatory element by Touchman (2001)
  39. 10.1074/jbc.M105326200 / J Biol Chem / Formation and removal of alpha-synuclein aggregates in cells exposed to mitochondrial inhibitors by Lee (2002)
  40. 10.1046/j.1471-4159.2001.00474.x / J Neurochem / Proteasomal inhibition leads to formation of ubiquitin/alpha-synuclein-immunoreactive inclusions in PC12 cells by Rideout (2001)
  41. 10.1093/hmg/10.9.919 / Hum Mol Genet / Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis by Tanaka (2001)
  42. 10.1016/S0304-3940(00)01701-8 / Neurosci Lett / Proteasomal function is impaired in substantia nigra in Parkinson's disease by McNaught (2001)
  43. 10.1056/NEJM200005253422103 / N Engl J Med / Association between early-onset Parkinson's disease and mutations in the parkin gene. French Parkinson's Disease Genetics Study Group by Lucking (2000)
  44. 10.1002/1531-8249(200007)48:1<65::AID-ANA10>3.0.CO;2-L / Ann Neurol / Parkin deletions in a family with adult-onset, tremor-dominant parkinsonism: expanding the phenotype by Klein (2000)
  45. 10.1212/WNL.57.2.359 / Neurology / The parkin gene is not involved in late-onset Parkinson's disease by Oliveri (2001)
  46. 10.1093/hmg/10.16.1649 / Hum Mol Genet / The importance of gene dosage studies: mutational analysis of the parkin gene in early-onset parkinsonism by Hedrich (2001)
  47. 10.1212/WNL.56.4.463 / Neurology / New mutation (R42P) of the parkin gene in the ubiquitinlike domain associated with parkinsonism by Terreni (2001)
  48. West A, Périquet M, Lincoln S, Lücking CB, Nicholl D, Bonifati V, Rawal N, Gasser T, Lohmann E, Deleuze JF et al.: The complex relationship between parkin mutations and Parkinson's disease, Am J Hum Genet 2002, in press. (10.1002/ajmg.10525)
  49. 10.1086/318791 / Am J Hum Genet / Origin of the mutations in the parkin gene in Europe: exon rearrangements are independent recurrent events, whereas point mutations may result from Founder effects by Periquet (2001)
  50. 10.1212/WNL.56.11.1573 / Neurology / Parkin gene causing benign autosomal recessive juvenile parkinsonism by Nisipeanu (2001)
  51. 10.1136/jnnp.71.2.231 / J Neurol Neurosurg Psychiatry / Homozygous deletion mutation of the parkin gene in patients with atypical parkinsonism by Kuroda (2001)
  52. 10.1212/WNL.56.4.555 / Neurology / Clinical and pathologic abnormalities in a family with parkinsonism and parkin gene mutations by van de Warrenburg (2001)
  53. 10.1212/WNL.56.12.1759 / Neurology / The nigrostriatal dopaminergic system in familial early onset parkinsonism with parkin mutations by Portman (2001)
  54. 10.1002/ana.74 / Ann Neurol / Positron emission tomographic analysis of the nigrostriatal dopaminergic system in familial parkinsonism associated with mutations in the parkin gene by Hilker (2001)
  55. 10.1002/ana.1132 / Ann Neurol / Lewy bodies and parkinsonism in families with parkin mutations by Farrer (2001)
  56. 10.1002/1531-8249(200008)48:2<245::AID-ANA15>3.0.CO;2-2 / Ann Neurol / Novel mutations, pseudo-dominant inheritance, and possible familial affects in patients with autosomal recessive juvenile parkinsonism by Maruyama (2000)
  57. 10.1007/s100720170042 / Neurol Sci / The parkin gene and its phenotype. Italian PD Genetics Study Group, French PD Genetics Study Group and the European Consortium on Genetic Susceptibility in Parkinson's Disease by Bonifati (2001)
  58. 10.1212/WNL.57.5.924 / Neurology / Pseudo-dominant inheritance and exon 2 triplication in a family with parkin gene mutations by Lücking (2001)
  59. 10.1002/ana.1143 / Ann Neurol / Parkin and Parkinson's: more than homonymy? by Corti (2001)
  60. 10.1016/S0092-8674(01)00407-X / Cell / An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin by Imai (2001)
  61. 10.1074/jbc.C000447200 / J Biol Chem / Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity by Imai (2000)
  62. 10.1073/pnas.240347797 / Proc Natl Acad Sci USA / Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1 by Zhang (2000)
  63. 10.1074/jbc.M109806200 / J Biol Chem / Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain by Fallon (2002)
  64. 10.1086/301713 / Am J Hum Genet / Diverse mutations in the gene for cartilage oligomeric matrix protein in the pseudoachondroplasia-multiple epiphyseal dysplasia disease spectrum by Briggs (1998)
  65. 10.1212/WNL.53.8.1858 / Neurology / Case-control study of the ubiquitin carboxy-terminal hydrolase L1 gene in Parkinson's disease by Maraganore (1999)
  66. 10.1016/S0022-510X(01)00555-X / J Neurol Sci / A polymorphic variation of serine to tyrosine at codon 18 in the ubiquitin C-terminal hydrolase-L1 gene is associated with a reduced risk of sporadic Parkinson's disease in a Japanese population by Satoh (2001)
  67. 10.1002/ana.10079 / Ann Neurol / Association studies of multiple candidate genes for Parkinson's disease using single nucleotide polymorphisms by Momose (2002)
  68. 10.1086/319522 / Am J Hum Genet / Localization of a novel locus for autosomal recessive early-onset parkinsonism, PARK6, on human chromosome 1p35-p36 by Valente (2001)
  69. 10.1002/mds.10034 / Mov Disord / Phenotypic characterisation of autosomal recessive PARK6-linked parkinsonism in three unrelated Italian families by Bentivoglio (2001)
  70. 10.1002/ana.10053 / Ann Neurol / PARK6-linked parkinsonism occurs in several European families by Valente (2002)
  71. 10.1086/322996 / Am J Hum Genet / Park7, a novel locus for autosomal recessive early-onset parkinsonism, on chromosome 1p36 by van Duijn (2001)
  72. 10.1002/ana.10106 / Ann Neurol / Localization of autosomal recessive early-onset parkinsonism to chromosome 1p36 (PARK7) in an independent dataset by Bonifati (2002)
  73. 10.1002/ana.10113 / Ann Neurol / A new locus for Parkinson's disease (PARK8) maps to chromosome 12p11.2-q13.1 by Funayama (2002)
  74. 10.1212/WNL.57.6.1124 / Neurology / Genome-wide scan for Parkinson's disease: the GenePD Study by DeStefano (2001)
  75. 10.1001/jama.286.18.2239 / J Am Med Assoc / Complete genomic screen in Parkinson disease: evidence for multiple genes by Scott (2001)
  76. 10.1002/1531-8249(20010201)49:2<263::AID-ANA50>3.0.CO;2-K / Ann Neurol / Familial atypical progressive supranuclear palsy associated with homozigosity for the delN296 mutation in the tau gene by Pastor (2001)
  77. 10.1002/mds.1087 / Mov Disord / The tau A0 allele in Parkinson's disease by Golbe (2001)
  78. 10.1002/ana.1228 / Ann Neurol / Case-Control study of the extended tau gene haplotype in Parkinson's disease by Maraganore (2001)
  79. 10.1001/jama.286.18.2324 / J Am Med Assoc / Tau and Parkinson disease by Spillantini (2001)
  80. {'key': '10.1016/S0959-437X(02)00302-7_BIB80', 'first-page': 'A200', 'article-title': "A susceptibility gene to late-onset idiopathic Parkinson's disease successfully mapped [Abstract 123]", 'volume': '69', 'author': 'Hicks', 'year': '2001', 'journal-title': 'Am J Hum Genet'} / Am J Hum Genet / A susceptibility gene to late-onset idiopathic Parkinson's disease successfully mapped [Abstract 123] by Hicks (2001)
Dates
Type When
Created 22 years, 10 months ago (Oct. 11, 2002, 7:58 a.m.)
Deposited 5 years, 5 months ago (March 5, 2020, 9:34 a.m.)
Indexed 1 month, 1 week ago (July 26, 2025, 5:13 a.m.)
Issued 23 years, 3 months ago (June 1, 2002)
Published 23 years, 3 months ago (June 1, 2002)
Published Print 23 years, 3 months ago (June 1, 2002)
Funders 0

None

@article{Lansbury_2002, title={Genetics of Parkinson’s disease and biochemical studies of implicated gene products}, volume={12}, ISSN={0959-437X}, url={http://dx.doi.org/10.1016/s0959-437x(02)00302-7}, DOI={10.1016/s0959-437x(02)00302-7}, number={3}, journal={Current Opinion in Genetics &amp; Development}, publisher={Elsevier BV}, author={Lansbury, Peter T and Brice, Alexis}, year={2002}, month=jun, pages={299–306} }