Crossref journal-article
Elsevier BV
Current Opinion in Genetics & Development (78)
Bibliography

Reik, A., Gregory, P. D., & Urnov, F. D. (2002). Biotechnologies and therapeutics: chromatin as a target. Current Opinion in Genetics & Development, 12(2), 233–242.

Authors 3
  1. Andreas Reik (first)
  2. Philip D Gregory (additional)
  3. Fyodor D Urnov (additional)
References 108 Referenced 19
  1. {'key': '10.1016/S0959-437X(02)00291-5_BIB1', 'series-title': 'Chromatin Structure and Function', 'author': 'Wolffe', 'year': '1998'} / Chromatin Structure and Function by Wolffe (1998)
  2. 10.1038/sj.onc.1204299 / Oncogene / Transcription therapy for cancer by Pandolfi (2001)
  3. {'key': '10.1016/S0959-437X(02)00291-5_BIB3', 'series-title': 'Biology as Ideology: The Doctrine of DNA', 'author': 'Lewontin', 'year': '1991'} / Biology as Ideology: The Doctrine of DNA by Lewontin (1991)
  4. 10.1038/35052073 / Nat Rev Mol Cell Biol / Untangling the ErbB signalling network by Yarden (2001)
  5. 10.1056/NEJM200104053441402 / N Engl J Med / Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome by Druker (2001)
  6. 10.1016/S0168-9525(00)02066-7 / Trends Genet / NuRD and SIN3 histone deacetylase complexes in development by Ahringer (2000)
  7. {'key': '10.1016/S0959-437X(02)00291-5_BIB7', 'first-page': '187', 'article-title': 'The host defence function of genomic methylation patterns', 'volume': '214', 'author': 'Bestor', 'year': '1998', 'journal-title': 'Novartis Found Symp'} / Novartis Found Symp / The host defence function of genomic methylation patterns by Bestor (1998)
  8. 10.1038/sj.onc.1204341 / Oncogene / DNA methylation, methyltransferases, and cancer by Robertson (2001)
  9. 10.1038/sj.onc.1204340 / Oncogene / Methyl CpG binding proteins: coupling chromatin architecture to gene regulation by Wade (2001)
  10. 10.1016/S0092-8674(00)81532-9 / Cell / Methylation-induced repression — belts, braces, and chromatin by Bird (1999)
  11. 10.1016/S1043-2760(01)00438-6 / Trends Endocrinol Metab / Histone deacetylase as a therapeutic target by Kramer (2001)
  12. {'key': '10.1016/S0959-437X(02)00291-5_BIB12', 'first-page': '135', 'article-title': 'DNA methylation inhibitors in the treatment of leukemias, myelodysplastic syndromes and hemoglobinopathies: clinical results and possible mechanisms of action', 'volume': '249', 'author': 'Lubbert', 'year': '2000', 'journal-title': 'Curr Top Microbiol Immunol'} / Curr Top Microbiol Immunol / DNA methylation inhibitors in the treatment of leukemias, myelodysplastic syndromes and hemoglobinopathies: clinical results and possible mechanisms of action by Lubbert (2000)
  13. 10.1038/35049533 / Nat Rev Genet / DNA methylation in health and disease by Robertson (2000)
  14. 10.2174/0929867013372058 / Curr Med Chem / Inhibitors of histone deacetylase as new anticancer agents by Jung (2001)
  15. 10.1097/00001622-200111000-00010 / Curr Opin Oncol / Histone deacetylase inhibitors as new cancer drugs by Marks (2001)
  16. 10.1021/jm00115a017 / J Med Chem / Antitumor properties of 2(1H)-pyrimidinone riboside (zebularine) and its fluorinated analogues by Driscoll (1991)
  17. 10.1038/35099568 / Nature / Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila by Steffan (2001)
  18. {'key': '10.1016/S0959-437X(02)00291-5_BIB18', 'first-page': '1790', 'article-title': 'Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease', 'volume': '93', 'author': 'Atweh', 'year': '1999', 'journal-title': 'Blood'} / Blood / Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease by Atweh (1999)
  19. 10.1182/blood.V63.1.201.201 / Blood / Perturbations in the erythroid marrow progenitor cell pools may play a role in the augmentation of HbF by 5-azacytidine by Torrealba-de Ron (1984)
  20. 10.1016/0092-8674(93)90051-Q / Cell / A positive role for histone acetylation in transcription factor access to nucleosomal DNA by Lee (1993)
  21. 10.1073/pnas.97.26.14494 / Proc Natl Acad Sci USA / Developmentally dynamic histone acetylation pattern of a tissue-specific chromatin domain by Forsberg (2000)
  22. 10.1016/S0092-8674(00)00169-0 / Cell / Ordered recruitment of chromatin modifying and general transcription factors to the IFN-beta promoter by Agalioti (2000)
  23. 10.1093/emboj/18.3.687 / EMBO J / Regulation of embryonic/fetal globin genes by nuclear hormone receptors: a novel perspective on hemoglobin switching by Filipe (1999)
  24. 10.1128/MCB.20.20.7572-7582.2000 / Mol Cell Biol / An ikaros-containing chromatin-remodeling complex in adult-type erythroid cells by O'Neill (2000)
  25. 10.1128/MCB.21.9.3118-3125.2001 / Mol Cell Biol / Unanticipated repression function linked to erythroid kruppel-like factor by Chen (2001)
  26. {'key': '10.1016/S0959-437X(02)00291-5_BIB26', 'first-page': '245', 'article-title': 'The expression of a small fraction of cellular genes is changed in response to histone hyperacetylation', 'volume': '5', 'author': 'Van Lint', 'year': '1996', 'journal-title': 'Gene Expr'} / Gene Expr / The expression of a small fraction of cellular genes is changed in response to histone hyperacetylation by Van Lint (1996)
  27. 10.1182/blood.V84.12.4344.bloodjournal84124344 / Blood / alpha-Amino butyric acid cannot reactivate the silenced gamma gene of the beta locus YAC transgenic mouse by Pace (1994)
  28. 10.1016/S1097-2765(01)00301-X / Mol Cell / Highly specific antibodies determine histone acetylation site usage in yeast heterochromatin and euchromatin by Suka (2001)
  29. 10.1038/47412 / Nature / The language of covalent histone modifications by Strahl (2000)
  30. 10.1101/gad.14.8.940 / Genes Dev / Nuclear localization and histone acetylation: a pathway for chromatin opening and transcriptional activation of the human beta-globin locus by Schubeler (2000)
  31. 10.1128/MCB.19.5.3496 / Mol Cell Biol / CREB-Binding protein acetylates hematopoietic transcription factor GATA-1 at functionally important sites by Hung (1999)
  32. 10.1074/jbc.M007846200 / J Biol Chem / Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation by Hung (2001)
  33. 10.1073/pnas.95.17.9855 / Proc Natl Acad Sci USA / Acetylation and modulation of erythroid Kruppel-like factor (EKLF) activity by interaction with histone acetyltransferases by Zhang (1998)
  34. 10.1038/25166 / Nature / Regulation of activity of the transcription factor GATA-1 by acetylation by Boyes (1998)
  35. 10.1093/nar/27.4.1168 / Nucleic Acids Res / Phosphorylation of GATA-1 increases its DNA-binding affinity and is correlated with induction of human K562 erythroleukaemia cells by Partington (1999)
  36. 10.1073/pnas.041599798 / Proc Natl Acad Sci USA / Mechanism for fetal globin gene expression: role of the soluble guanylate cyclase-cGMP-dependent protein kinase pathway by Ikuta (2001)
  37. 10.1182/blood.V97.10.3259 / Blood / Short-chain fatty acid derivatives stimulate cell proliferation and induce STAT-5 activation by Boosalis (2001)
  38. 10.4049/jimmunol.167.9.5160 / J Immunol / Loss of pu.1 expression following inhibition of histone deacetylases by Laribee (2001)
  39. 10.1073/pnas.94.11.5798 / Proc Natl Acad Sci USA / Reactivation of silenced, virally transduced genes by inhibitors of histone deacetylase by Chen (1997)
  40. 10.1038/5047 / Nat Genet / Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer by Cameron (1999)
  41. 10.1073/pnas.97.1.377 / Proc Natl Acad Sci USA / Molecular mechanism for silencing virally transduced genes involves histone deacetylation and chromatin condensation by Chen (2000)
  42. 10.1016/0092-8674(87)90584-8 / Cell / Position-independent, high-level expression of the human beta-globin gene in transgenic mice by Grosveld (1987)
  43. 10.1002/j.1460-2075.1994.tb06605.x / EMBO J / Mutagenesis of retroviral vectors transducing human beta-globin gene and beta-globin locus control region derivatives results in stable transmission of an active transcriptional structure by Leboulch (1994)
  44. 10.1073/pnas.92.15.6728 / Proc Natl Acad Sci USA / Generation of a high-titer retroviral vector capable of expressing high levels of the human beta-globin gene by Sadelain (1995)
  45. 10.1128/JVI.73.7.5490-5496.1999 / J Virol / Amelioration of retroviral vector silencing in locus control region beta-globin-transgenic mice and transduced F9 embryonic cells by Osborne (1999)
  46. 10.1034/j.1399-0004.2001.590103.x / Clin Genet / The beta-globin locus control region versus gene therapy vectors: a struggle for expression by Ellis (2001)
  47. 10.1093/hmg/9.4.631 / Hum Mol Genet / Beta-globin YAC transgenes exhibit uniform expression levels but position effect variegation in mice by Alami (2000)
  48. 10.1128/MCB.18.10.5992 / Mol Cell Biol / The locus control region is necessary for gene expression in the human beta-globin locus but not the maintenance of an open chromatin structure in erythroid cells by Reik (1998)
  49. 10.1016/S1097-2765(00)80433-5 / Mol Cell / Beta-globin gene switching and DNase I sensitivity of the endogenous beta-globin locus in mice do not require the locus control region by Bender (2000)
  50. 10.1093/emboj/18.14.4035 / EMBO J / An insulator element and condensed chromatin region separate the chicken beta-globin locus from an independently regulated erythroid-specific folate receptor gene by Prioleau (1999)
  51. 10.1126/science.1064413 / Science / Correlation between histone lysine methylation and developmental changes at the chicken beta-globin locus by Litt (2001)
  52. 10.1093/emboj/20.9.2224 / EMBO J / Transitions in histone acetylation reveal boundaries of three separately regulated neighboring loci by Litt (2001)
  53. 10.1016/0092-8674(93)80052-G / Cell / A 5’ element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila by Chung (1993)
  54. 10.1101/gad.12.18.2852 / Genes Dev / Loss of transcriptional activity of a transgene is accompanied by DNA methylation and histone deacetylation and is prevented by insulators by Pikaart (1998)
  55. 10.1016/S0092-8674(00)81967-4 / Cell / The protein CTCF is required for the enhancer blocking activity of vertebrate insulators by Bell (1999)
  56. 10.1128/MCB.13.12.7612 / Mol Cell Biol / CTCF, a conserved nuclear factor required for optimal transcriptional activity of the chicken c-myc gene, is an 11-Zn-finger protein differentially expressed in multiple forms by Klenova (1993)
  57. 10.1038/ng570 / Nat Genet / CTCF-binding sites flank CTG/CAG repeats and form a methylation-sensitive insulator at the DM1 locus by Filippova (2001)
  58. 10.1128/JVI.74.10.4679-4687.2000 / J Virol / The cHS4 insulator increases the probability of retroviral expression at random chromosomal integration sites by Rivella (2000)
  59. 10.1073/pnas.160159597 / Proc Natl Acad Sci USA / A chromatin insulator protects retrovirus vectors from chromosomal position effects by Emery (2000)
  60. 10.1007/s100380050133 / J Hum Genet / Position-independent human beta-globin gene expression mediated by a recombinant adeno-associated virus vector carrying the chicken beta-globin insulator by Inoue (1999)
  61. {'key': '10.1016/S0959-437X(02)00291-5_BIB61', 'first-page': '75', 'article-title': 'Relationship between transcription and DNA methylation', 'volume': '249', 'author': 'Chan', 'year': '2000', 'journal-title': 'Curr Top Microbiol Immunol'} / Curr Top Microbiol Immunol / Relationship between transcription and DNA methylation by Chan (2000)
  62. 10.1128/MCB.21.22.7807-7816.2001 / Mol Cell Biol / Specific double-stranded rna interference in undifferentiated mouse embryonic stem cells by Yang (2001)
  63. 10.1016/S1097-2765(01)00364-1 / Mol Cell / Generation of stable mRNA fragments and translation of N-truncated proteins induced by antisense oligodeoxynucleotides by Thoma (2001)
  64. 10.1146/annurev.biophys.29.1.183 / Annu Rev Biophys Biomol Struct / DNA recognition by Cys2His2 zinc finger proteins by Wolfe (2000)
  65. 10.1038/35057011 / Nature / Expressing the human genome by Tupler (2001)
  66. 10.1124/mol.58.1.1 / Mol Pharmacol / Regulation of the MDR1 gene by transcriptional repressors selected using peptide combinatorial libraries by Bartsevich (2000)
  67. 10.1146/annurev.biochem.70.1.313 / Annu Rev Biochem / Design and selection of novel cys2his2 zinc finger proteins by Pabo (2001)
  68. 10.1074/jbc.M011172200 / J Biol Chem / Regulation of an endogenous locus using a panel of designed zinc finger proteins targeted to accessible chromatin regions. Activation of vascular endothelial growth factor A by Liu (2001)
  69. 10.1074/jbc.M005341200 / J Biol Chem / Synthetic zinc finger transcription factor action at an endogenous chromosomal site. Activation of the human erythropoietin gene by Zhang (2000)
  70. 10.1101/gad.911501 / Genes Dev / The S. cerevisiae SAGA complex functions in vivo as a coactivator for transcriptional activation by Gal4 by Larschan (2001)
  71. 10.1073/pnas.040552697 / Proc Natl Acad Sci USA / Positive and negative regulation of endogenous genes by designed transcription factors by Beerli (2000)
  72. 10.1093/emboj/18.22.6385 / EMBO J / Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family by Nielsen (1999)
  73. 10.1101/gad.869501 / Genes Dev / Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD by Schultz (2001)
  74. {'key': '10.1016/S0959-437X(02)00291-5_BIB74', 'first-page': '169', 'article-title': 'Design of dominant negatives to bHLHZip proteins that inhibit DNA binding', 'volume': '224', 'author': 'Krylov', 'year': '1997', 'journal-title': 'Curr Top Microbiol Immunol'} / Curr Top Microbiol Immunol / Design of dominant negatives to bHLHZip proteins that inhibit DNA binding by Krylov (1997)
  75. 10.1126/science.1063206 / Science / Nuclear cloning and epigenetic reprogramming of the genome by Rideout (2001)
  76. 10.1038/70709 / Nat Biotechnol / Prospects for the use of nuclear transfer in human transplantation by Lanza (1999)
  77. 10.1038/80242 / Nat Biotechnol / Production of cloned pigs from in vitro systems by Betthauser (2000)
  78. 10.1126/science.278.5346.2130 / Science / Human factor IX transgenic sheep produced by transfer of nuclei from transfected fetal fibroblasts by Schnieke (1997)
  79. 10.1038/nbt1001-962 / Nat Biotechnol / Genetic rescue of an endangered mammal by cross-species nuclear transfer using post-mortem somatic cells by Loi (2001)
  80. 10.1126/science.1064020 / Science / Imprinting and the epigenetic asymmetry between parental genomes by Ferguson-Smith (2001)
  81. 10.1038/84769 / Nat Genet / Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture by Young (2001)
  82. 10.1101/gad.11.23.3128 / Genes Dev / Mouse mutant embryos overexpressing IGF-II exhibit phenotypic features of the Beckwith-Wiedemann and Simpson-Golabi-Behmel syndromes by Eggenschwiler (1997)
  83. 10.1126/science.1061402 / Science / Epigenetic instability in ES cells and cloned mice by Humpherys (2001)
  84. 10.1038/72753 / Nat Genet / Generation of mice from wild-type and targeted ES cells by nuclear cloning by Rideout (2000)
  85. 10.1073/pnas.101118898 / Proc Natl Acad Sci USA / Hybrid vigor, fetal overgrowth, and viability of mice derived by nuclear cloning and tetraploid embryo complementation by Eggan (2001)
  86. 10.1073/pnas.111182398 / Proc Natl Acad Sci USA / Factors affecting the developmental potential of cloned mammalian embryos by Cross (2001)
  87. 10.1074/jbc.M106516200 / J Biol Chem / Typical demethylation events in cloned pig embryos. clues on species-specific differences in epigenetic reprogramming of a cloned donor genome by Kang (2001)
  88. 10.1038/88903 / Nat Genet / Aberrant methylation of donor genome in cloned bovine embryos by Kang (2001)
  89. 10.1016/S0960-9822(01)00480-8 / Curr Biol / Delayed and incomplete reprogramming of chromosome methylation patterns in bovine cloned embryos by Bourc'his (2001)
  90. 10.1002/(SICI)1521-1878(199807)20:7<555::AID-BIES6>3.0.CO;2-J / Bioessays / Molecular mechanisms of male germ cell differentiation by Hecht (1998)
  91. 10.1126/science.1063443 / Science / Epigenetic reprogramming in mammalian development by Reik (2001)
  92. 10.1016/S0960-9822(00)00448-6 / Curr Biol / Active demethylation of the paternal genome in the mouse zygote by Oswald (2000)
  93. 10.1126/science.289.5488.2360 / Science / Active remodeling of somatic nuclei in egg cytoplasm by the nucleosomal ATPase ISWI by Kikyo (2000)
  94. 10.1016/S0092-8674(00)00134-3 / Cell / The Isw2 chromatin remodeling complex represses early meiotic genes upon recruitment by Ume6p by Goldmark (2000)
  95. 10.1128/MCB.21.19.6450-6460.2001 / Mol Cell Biol / Widespread collaboration of Isw2 and Sin3-Rpd3 chromatin remodeling complexes in transcriptional repression by Fazzio (2001)
  96. 10.1126/science.1060463 / Science / Developmental biology. Don't clone humans! by Jaenisch (2001)
  97. 10.1126/science.294.5543.870 / Science / The plasticity of dendritic cell responses to pathogens and their components by Huang (2001)
  98. 10.1038/ng724 / Nat Genet / Identifying regulatory networks by combinatorial analysis of promoter elements by Pilpel (2001)
  99. 10.1038/74487 / Nat Biotechnol / Identification of in vivo DNA targets of chromatin proteins using tethered dam methyltransferase by van Steensel (2000)
  100. 10.1038/85871 / Nat Genet / Chromatin profiling using targeted DNA adenine methyltransferase by van Steensel (2001)
  101. 10.1126/science.1065806 / Science / Correction of sickle cell disease in transgenic mouse models by gene therapy by Pawliuk (2001)
  102. 10.1073/pnas.261574398 / Proc Natl Acad Sci USA / Identification of a small molecule inhibitor of Sir2p by Bedalov (2001)
  103. 10.1074/jbc.M106779200 / J Biol Chem / Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening by Grozinger (2001)
  104. 10.1182/blood.V98.9.2865 / Blood / Inhibitor of histone deacetylation, depsipeptide (FR901228), in the treatment of peripheral and cutaneous T-cell lymphoma: a case report by Piekarz (2001)
  105. 10.1101/gad.953802 / Genes Dev / PPARg knockdown by engineered transcription factors: exogenous PPARγ2 but not PPARγ1 reactivates adipogenesis by Ren (2002)
  106. 10.1126/science.1068228 / Science / Production of α-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning by Lai (2002)
  107. 10.1006/dbio.2001.0501 / Dev Biol / Dynamic reprogramming of DNA methylation in the early mouse embryo by Santos (2002)
  108. 10.1093/hmg/10.26.2983 / Hum Mol Genet / Genome-wide methylation patterns in normal and uniparental early mouse embryos by Barton (2001)
Dates
Type When
Created 22 years, 10 months ago (Oct. 8, 2002, 11:17 a.m.)
Deposited 2 years, 4 months ago (April 24, 2023, 4:53 p.m.)
Indexed 2 months ago (July 2, 2025, 2:45 p.m.)
Issued 23 years, 5 months ago (April 1, 2002)
Published 23 years, 5 months ago (April 1, 2002)
Published Print 23 years, 5 months ago (April 1, 2002)
Funders 0

None

@article{Reik_2002, title={Biotechnologies and therapeutics: chromatin as a target}, volume={12}, ISSN={0959-437X}, url={http://dx.doi.org/10.1016/s0959-437x(02)00291-5}, DOI={10.1016/s0959-437x(02)00291-5}, number={2}, journal={Current Opinion in Genetics &amp; Development}, publisher={Elsevier BV}, author={Reik, Andreas and Gregory, Philip D and Urnov, Fyodor D}, year={2002}, month=apr, pages={233–242} }