DOI: 10.1016/s0939-6411(99)00075-2. Vitamin A loaded solid lipid nanoparticles for topical use: occlusive properties and drug targeting to the upper skin

Vitamin A loaded solid lipid nanoparticles for topical use: occlusive properties and drug targeting to the upper skin

10.1016/s0939-6411(99)00075-2

Crossref journal-article

Elsevier BV

European Journal of Pharmaceutics and Biopharmaceutics (78)

Bibliography

Jenning, V., Gysler, A., SchÃ¤fer-Korting, M., & Gohla, S. H. (2000). Vitamin A loaded solid lipid nanoparticles for topical use: occlusive properties and drug targeting to the upper skin. European Journal of Pharmaceutics and Biopharmaceutics, 49(3), 211â218.

Authors 4

Volkhard Jenning (first)
Anja Gysler (additional)
Monika Schäfer-Korting (additional)
Sven H Gohla (additional)

References 37 Referenced 394

{'key': '10.1016/S0939-6411(99)00075-2_BIB1', 'first-page': '62', 'article-title': 'Solid lipid nanoparticles (SLN) – an alternative colloidal carrier system for controlled drug delivery', 'volume': '41', 'author': 'Müller', 'year': '1995', 'journal-title': 'Eur. J. Pharm. Biopharm.'} / Eur. J. Pharm. Biopharm. / Solid lipid nanoparticles (SLN) – an alternative colloidal carrier system for controlled drug delivery by Müller (1995)
{'key': '10.1016/S0939-6411(99)00075-2_BIB2', 'first-page': '24S', 'article-title': 'Influence of production parameters of solid lipid nanoparticles (SLN) on the suitability for intravenous injection', 'volume': '40', 'author': 'Schwarz', 'year': '1994', 'journal-title': 'Eur. J. Pharm. Biopharm.'} / Eur. J. Pharm. Biopharm. / Influence of production parameters of solid lipid nanoparticles (SLN) on the suitability for intravenous injection by Schwarz (1994)
10.3109/02652049809006847 / J. Microencapsul. / Drug retention and stability of solid lipid nanoparticles containing azidothymidine palmitate after autoclaving, storage and lyophilization by Heiati (1998)
{'key': '10.1016/S0939-6411(99)00075-2_BIB4', 'first-page': '121', 'article-title': 'Liposphere parenteral delivery systems', 'volume': '20', 'author': 'Domb', 'year': '1993', 'journal-title': 'Proc. Int. Symp. Control. Rel. Bioact. Mater.'} / Proc. Int. Symp. Control. Rel. Bioact. Mater. / Liposphere parenteral delivery systems by Domb (1993)
{'key': '10.1016/S0939-6411(99)00075-2_BIB5', 'first-page': '123', 'article-title': 'Submicron-sized parenteral carrier systems based on solid lipids', 'volume': '1', 'author': 'Siekmann', 'year': '1992', 'journal-title': 'Pharm. Pharmacol. Lett.'} / Pharm. Pharmacol. Lett. / Submicron-sized parenteral carrier systems based on solid lipids by Siekmann (1992)
{'key': '10.1016/S0939-6411(99)00075-2_BIB6', 'first-page': '19', 'article-title': 'The next generation after the liposomes: solid lipid nanoparticles (SLN/Lipopearls) as dermal carrier in cosmetics', 'volume': '7/8', 'author': 'Müller', 'year': '1998', 'journal-title': 'Euro Cosmet.'} / Euro Cosmet. / The next generation after the liposomes: solid lipid nanoparticles (SLN/Lipopearls) as dermal carrier in cosmetics by Müller (1998)
{'key': '10.1016/S0939-6411(99)00075-2_BIB7', 'first-page': '155', 'article-title': 'Peptide-loaded solid lipid nanoparticles (SLN): influence of production parameters', 'volume': '136', 'author': 'Almeida', 'year': '1996', 'journal-title': 'Int. J. Pharm.'} / Int. J. Pharm. / Peptide-loaded solid lipid nanoparticles (SLN): influence of production parameters by Almeida (1996)
S.A. Runge, Feste Lipid Nanopartikel (SLN) als kolloidaler Arzneistoffträger für die orale Applikation von Ciclosporin A, Ph.D. thesis, FU Berlin, 1998.
10.1016/0378-5173(96)04539-5 / Int. J. Pharm. / Cytotoxicity of magnetite loaded polylactide, polylactide/glycolide particles and solid lipid nanoparticles by Müller (1996)
{'key': '10.1016/S0939-6411(99)00075-2_BIB10', 'first-page': '42', 'article-title': 'Controlled release subdued', 'volume': '22', 'author': 'Eury', 'year': '1992', 'journal-title': 'Chemtech'} / Chemtech / Controlled release subdued by Eury (1992)
10.1016/0190-9622(91)70109-F / J. Am. Acad. Dermatol. / Controlled release of benzoyl peroxide from a porous microsphere polymeric system can reduce topical irritancy by Wester (1991)
10.1002/jps.2600820104 / J. Pharm. Sci. / Cutaneous bioavailability in hairless rats of tretinoin in liposomes or gel by Masini (1993)
10.1007/BF00577761 / Clin. Invest. / Liposomal tretinoin for uncomplicated acne vulgaris by Schäfer-Korting (1994)
10.3109/02652049609026042 / J. Microencapsul. / The microsponge delivery system: a topical delivery system with reduced irritancy incorporating multiple triggering mechanisms for the release of actives by Embil (1996)
{'key': '10.1016/S0939-6411(99)00075-2_BIB15', 'series-title': 'New generation of cosmetic products based on solid lipid nanoparticles (lipoperls)', 'first-page': '585', 'author': 'Schütt', 'year': '1998'} / New generation of cosmetic products based on solid lipid nanoparticles (lipoperls) by Schütt (1998)
10.1002/jps.2600840415 / J. Pharm. Sci. / Preparation and structure of a water-in-oil cream containing lipid nanoparticles by De Vringer (1995)
10.1016/S0378-5173(98)00137-9 / Int. J. Pharm. / In vitro measurements of transepidermal water loss: a rapid alternative to tritiated water permeation for assessing skin barrier function by Nangia (1998)
10.1111/1523-1747.ep12335788 / J. Invest. Dermatol. / Unoccluded retinol penetrates human skin in vivo more effectively than unoccluded retinyl palmitate or retinoic acid by Duell (1997)
R.H. Müller, J.S. Lucks, Arzneistoffträger aus festen Lipidteilchen - Feste Lipid Nanosphären (SLN), European patent application EP 0 605 497 B1 (1996).
10.1002/jps.2600800605 / J. Pharm. Sci. / Percutanous penetration and skin retention of topically applied compounds: an in vitro–in vivo study by Reifenrath (1991)
10.1016/S0168-3659(98)00060-1 / J. Control. Rel. / Methods for quantitative determination of drug localized in the skin by Touitou (1998)
10.1159/000401274 / Curr. Probl. Dermatol. / The skin of domestic mammals as a model for human skin with special reference to the domestic pig by Meyer (1978)
{'key': '10.1016/S0939-6411(99)00075-2_BIB23', 'first-page': '197', 'article-title': 'In vitro methods for the biopharmaceutical evaluation of topical formulations', 'volume': '36', 'author': 'Neubert', 'year': '1990', 'journal-title': 'Acta Pharm. Technol.'} / Acta Pharm. Technol. / In vitro methods for the biopharmaceutical evaluation of topical formulations by Neubert (1990)
{'key': '10.1016/S0939-6411(99)00075-2_BIB24', 'series-title': 'Transdermal Drug Delivery', 'first-page': '23', 'article-title': 'Physical characterization of the stratum corneum: the relationship of mechanical and barrier properties of lipid and protein structure', 'author': 'Potts', 'year': '1989'} / Transdermal Drug Delivery / Physical characterization of the stratum corneum: the relationship of mechanical and barrier properties of lipid and protein structure by Potts (1989)
10.1016/S0939-6411(98)00074-5 / Eur. J. Pharm. Biopharm. / Correlation between long-term stability of solid lipid nanoparticles (SLN) and crystallinity of the lipid phase by Freitas (1999)
V. Jenning, M. Schäfer-Korting, S. Gohla, Vitamin A loaded solid lipid nanoparticles for topical use: drug release properties, J. Control. Rel. (2000) in press. (10.1016/S0168-3659(99)00223-0)
10.1111/1523-1747.ep12329576 / J. Invest. Dermatol. / Extraction of human epidermis treated with retinol yields retro-retinoids in addition to free retinol and retinyl esters by Duell (1996)
T. de Vringer, Topical preparation containing a suspension of solid lipid particles, European Patent Application EP 0 506 197 A1 (1992).
{'key': '10.1016/S0939-6411(99)00075-2_BIB29', 'first-page': '175', 'article-title': 'Effect of collagen microparticles on the stability of retinol and its absorbtion into hairless mouse skin in vitro', 'volume': '49', 'author': 'Rössler', 'year': '1994', 'journal-title': 'Pharmazie'} / Pharmazie / Effect of collagen microparticles on the stability of retinol and its absorbtion into hairless mouse skin in vitro by Rössler (1994)
{'key': '10.1016/S0939-6411(99)00075-2_BIB30', 'series-title': 'Topical Drug Delivery Formulations', 'first-page': '1', 'article-title': 'Practical considerations for topical drug formulations with and without enhancers', 'author': 'Cooper', 'year': '1990'} / Topical Drug Delivery Formulations / Practical considerations for topical drug formulations with and without enhancers by Cooper (1990)
{'key': '10.1016/S0939-6411(99)00075-2_BIB31', 'series-title': 'Transdermal Drug Delivery', 'first-page': '150', 'article-title': 'The in vitro evaluation of transdermal delivery', 'author': 'Gummer', 'year': '1989'} / Transdermal Drug Delivery / The in vitro evaluation of transdermal delivery by Gummer (1989)
{'key': '10.1016/S0939-6411(99)00075-2_BIB32', 'series-title': 'Transdermal Drug Delivery', 'first-page': '197', 'article-title': 'Penetration enhancers and their use in transdermal therapeutic systems', 'author': 'Walters', 'year': '1989'} / Transdermal Drug Delivery / Penetration enhancers and their use in transdermal therapeutic systems by Walters (1989)
{'key': '10.1016/S0939-6411(99)00075-2_BIB33', 'series-title': 'The Benefit/ Risk Ratio. A Handbook for Rational Use of Potentially Hazardous Drugs', 'first-page': '333', 'article-title': 'Topical liposome drugs', 'author': 'Korting', 'year': '1998'} / The Benefit/ Risk Ratio. A Handbook for Rational Use of Potentially Hazardous Drugs / Topical liposome drugs by Korting (1998)
{'key': '10.1016/S0939-6411(99)00075-2_BIB34', 'series-title': 'The Benefit/Risk Ratio. A Handbook for Rational Use of Potentially Hazardous Drugs', 'first-page': '361', 'article-title': 'Topical glucocorticoids with improved risk-benefit ratio', 'author': 'Schäfer-Korting', 'year': '1998'} / The Benefit/Risk Ratio. A Handbook for Rational Use of Potentially Hazardous Drugs / Topical glucocorticoids with improved risk-benefit ratio by Schäfer-Korting (1998)
{'key': '10.1016/S0939-6411(99)00075-2_BIB35', 'series-title': 'Characterization of skin penetration of microfine titanium dioxide used in sunscreen formulations', 'first-page': '859', 'author': 'Bennat', 'year': '1998'} / Characterization of skin penetration of microfine titanium dioxide used in sunscreen formulations by Bennat (1998)
10.1002/lipi.19700721116 / Seifen Fette Anstrichmittel / Partikelgröβe und Permeation by Wolter (1970)
10.1111/1523-1747.ep12323445 / J. Invest. Dermatol. / Application of retinol to human skin in vivo induces epidermal hyperplasie and cellular retinoid binding proteins characteristic of retinoic acid but without measurable retinoic acid levels or irritation by Kang (1995)

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 6:32 p.m.)
Deposited	6 years, 4 months ago (April 14, 2019, 5:55 a.m.)
Indexed	16 hours ago (Aug. 30, 2025, 1:15 p.m.)
Issued	25 years, 3 months ago (May 1, 2000)
Published	25 years, 3 months ago (May 1, 2000)
Published Print	25 years, 3 months ago (May 1, 2000)

Funders 0

None

BibTeX

@article{Jenning_2000, title={Vitamin A loaded solid lipid nanoparticles for topical use: occlusive properties and drug targeting to the upper skin}, volume={49}, ISSN={0939-6411}, url={http://dx.doi.org/10.1016/s0939-6411(99)00075-2}, DOI={10.1016/s0939-6411(99)00075-2}, number={3}, journal={European Journal of Pharmaceutics and Biopharmaceutics}, publisher={Elsevier BV}, author={Jenning, Volkhard and Gysler, Anja and Schäfer-Korting, Monika and Gohla, Sven H}, year={2000}, month=may, pages={211–218} }

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