DOI: 10.1016/s0896-6273(01)00331-2. Sympathetic Innervation of Lymphoreticular Organs Is Rate Limiting for Prion Neuroinvasion

Sympathetic Innervation of Lymphoreticular Organs Is Rate Limiting for Prion Neuroinvasion

10.1016/s0896-6273(01)00331-2

Crossref journal-article

Elsevier BV

Neuron (78)

Bibliography

Glatzel, M., Heppner, F. L., Albers, K. M., & Aguzzi, A. (2001). Sympathetic Innervation of Lymphoreticular Organs Is Rate Limiting for Prion Neuroinvasion. Neuron, 31(1), 25â34.

Authors 4

Markus Glatzel (first)
Frank L. Heppner (additional)
Kathryn M. Albers (additional)
Adriano Aguzzi (additional)

References 38 Referenced 197

10.1038/39758 / Nature / Prion research by Aguzzi (1997)
10.1038/35052063 / Nat. Rev. Mol. Cell. Biol. / Prions by Aguzzi (2001)
10.1099/0022-1317-78-5-1187 / J. Gen. Virol. / Evidence for an alternative direct route of access for the scrapie agent to the brain bypassing the spinal cord by Baldauf (1997)
10.1099/0022-1317-77-8-1925 / J. Gen. Virol. / Sequential appearance and accumulation of pathognomonic markers in the central nervous system of hamsters orally infected with scrapie by Beekes (1996)
10.1099/0022-1317-79-3-601 / J. Gen. Virol. / Cerebral targeting indicates vagal spread of infection in hamsters fed with scrapie by Beekes (1998)
10.1038/37981 / Nature / PrP-expressing tissue required for transfer of scrapie infectivity from spleen to brain by Blättler (1997)
10.1038/379339a0 / Nature / Normal host prion protein necessary for scrapie-induced neurotoxicity by Brandner (1996)
10.1016/0092-8674(93)90360-3 / Cell / Mice devoid of PrP are resistant to scrapie by Büeler (1993)
10.1523/JNEUROSCI.15-09-05892.1995 / J. Neurosci. / NGF modulates sympathetic innervation of lymphoid tissues by Carlson (1995)
10.1006/brbi.1997.0501 / Brain Behav. Immun. / Catecholamine modulation of lymphocyte homing to lymphoid tissues by Carlson (1997)
10.1016/0378-1135(84)90039-7 / Vet. Microbiol. / Pathogenesis of mouse scrapie by Clarke (1984)
10.1111/j.1365-2990.1985.tb00019.x / Neuropathol. Appl. Neurobiol. / Pathogenesis of mouse scrapie by Cole (1985)
10.1093/infdis/117.1.15 / J. Infect. Dis. / Pathogenesis of scrapie virus infection in the mouse by Eklund (1967)
10.1099/0022-1317-77-8-1941 / J. Gen. Virol. / Protease-resistant Prp deposition in brain and non-central nervous system tissues of a murine model of bovine spongiform encephalopathy by Farquhar (1996)
10.1016/0889-1591(88)90031-1 / Brain Behav. Immun. / Sympathetic noradrenergic innervation of immune organs by Felten (1988)
10.1002/j.1460-2075.1996.tb00467.x / EMBO J. / Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie by Fischer (1996)
10.1038/35044100 / Nature / Binding of disease-associated prion protein to plasminogen by Fischer (2000)
10.1016/S1286-4579(00)00364-6 / Microbes Infect. / Peripheral pathogenesis of prion diseases by Glatzel (2000)
10.1099/0022-1317-81-11-2813 / J. Gen. Virol. / PrP(C) expression in the peripheral nervous system is a determinant of prion neuroinvasion by Glatzel (2000)
10.1073/pnas.97.1.442 / Proc. Natl. Acad. Sci. USA / Adenoviral and adeno-associated viral transfer of genes to the peripheral nervous system by Glatzel (2000)
10.1007/s004010051109 / Acta Neuropathol. / Disease associated prion protein may deposit in the peripheral nervous system in human transmissible spongiform encephalopathies by Hainfellner (1999)
10.1016/0168-1702(89)90039-7 / Virus Res. / The role of the spleen in the neuroinvasion of scrapie in mice by Kimberlin (1989)
10.1016/0022-510X(83)90165-X / J. Neurol. Sci. / Pathogenesis of mouse scrapie. Evidence for direct neural spread of infection to the CNS after injection of sciatic nerve by Kimberlin (1983)
10.1128/JVI.65.11.6292-6295.1991 / J. Virol. / Abnormal isoform of prion protein accumulates in follicular dendritic cells in mice with Creutzfeldt-Jakob disease by Kitamoto (1991)
10.1038/37789 / Nature / A crucial role for B cells in neuroinvasive scrapie by Klein (1997)
10.1038/4022 / Nat. Med. / PrP expression in B lymphocytes is not required for prion neuroinvasion by Klein (1998)
10.1038/86567 / Nat. Med. / Complement facilitates early prion pathogenesis by Klein (2001)
10.4049/jimmunol.162.9.5299 / J. Immunol. / Suppression of antigen-specific Th2 cell-dependent IgM and IgG1 production following norepinephrine depletion in vivo by Kohm (1999)
10.4049/jimmunol.155.10.4613 / J. Immunol. / Alterations in cytokine and antibody production following chemical sympathectomy in two strains of mice by Kruszewska (1995)
10.1128/JVI.70.2.1292-1295.1996 / J. Virol. / Immune system-dependent and -independent replication of the scrapie agent by Lasmezas (1996)
10.1016/0165-5728(94)90182-1 / J. Neuroimmunol. / Sympathetic nervous system modulation of the immune system. II. Induction of lymphocyte proliferation and migration in vivo by chemical sympathectomy by Madden (1994)
10.1016/S0304-3940(99)00223-2 / Neurosci. Lett. / Pathological PrP is abundant in sympathetic and sensory ganglia of hamsters fed with scrapie by McBride (1999)
10.1126/science.288.5469.1257 / Science / Impaired prion replication in spleens of mice lacking functional follicular dendritic cells by Montrasio (2000)
10.1016/S0165-1838(96)00121-X / J. Auton. Nerv. Syst. / Methods of sympathetic degeneration and alteration by Picklo (1997)
10.1126/science.6801762 / Science / Novel proteinaceous infectious particles cause scrapie by Prusiner (1982)
10.1002/ana.410110406 / Ann. Neurol. / Measurement of the scrapie agent using an incubation time interval assay by Prusiner (1982)
10.1128/JVI.74.2.828-833.2000 / J. Virol. / Entry versus blockade of brain infection following oral or intraperitoneal scrapie administration by Race (2000)
10.1073/pnas.89.16.7620 / Proc. Natl. Acad. Sci. USA / Regional mapping of prion proteins in brain by Taraboulos (1992)

Dates

Type	When
Created	21 years, 4 months ago (April 21, 2004, 3:12 a.m.)
Deposited	2 years, 4 months ago (April 28, 2023, 7:55 a.m.)
Indexed	1 day, 14 hours ago (Sept. 3, 2025, 7:01 a.m.)
Issued	24 years, 2 months ago (July 1, 2001)
Published	24 years, 2 months ago (July 1, 2001)
Published Print	24 years, 2 months ago (July 1, 2001)

Funders 0

None

BibTeX

@article{Glatzel_2001, title={Sympathetic Innervation of Lymphoreticular Organs Is Rate Limiting for Prion Neuroinvasion}, volume={31}, ISSN={0896-6273}, url={http://dx.doi.org/10.1016/s0896-6273(01)00331-2}, DOI={10.1016/s0896-6273(01)00331-2}, number={1}, journal={Neuron}, publisher={Elsevier BV}, author={Glatzel, Markus and Heppner, Frank L. and Albers, Kathryn M. and Aguzzi, Adriano}, year={2001}, month=jul, pages={25–34} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        9,
        3
      ]
    ],
    "date-time": "2025-09-03T11:01:18Z",
    "timestamp": 1756897278833
  },
  "reference-count": 38,
  "publisher": "Elsevier BV",
  "issue": "1",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2001,
            7,
            1
          ]
        ],
        "date-time": "2001-07-01T00:00:00Z",
        "timestamp": 993945600000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2013,
            7,
            17
          ]
        ],
        "date-time": "2013-07-17T00:00:00Z",
        "timestamp": 1374019200000
      },
      "content-version": "vor",
      "delay-in-days": 4399,
      "URL": "https://www.elsevier.com/open-access/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2001,
        7
      ]
    ]
  },
  "DOI": "10.1016/s0896-6273(01)00331-2",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2004,
        4,
        21
      ]
    ],
    "date-time": "2004-04-21T07:12:17Z",
    "timestamp": 1082531537000
  },
  "page": "25-34",
  "source": "Crossref",
  "is-referenced-by-count": 197,
  "title": "Sympathetic Innervation of Lymphoreticular Organs Is Rate Limiting for Prion Neuroinvasion",
  "prefix": "10.1016",
  "volume": "31",
  "author": [
    {
      "given": "Markus",
      "family": "Glatzel",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Frank L.",
      "family": "Heppner",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Kathryn M.",
      "family": "Albers",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Adriano",
      "family": "Aguzzi",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/S0896-6273(01)00331-2_BIB1",
      "doi-asserted-by": "crossref",
      "first-page": "795",
      "DOI": "10.1038/39758",
      "article-title": "Prion research",
      "volume": "389",
      "author": "Aguzzi",
      "year": "1997",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0896-6273(01)00331-2_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "118",
      "DOI": "10.1038/35052063",
      "article-title": "Prions",
      "volume": "2",
      "author": "Aguzzi",
      "year": "2001",
      "journal-title": "Nat. Rev. Mol. Cell. Biol."
    },
    {
      "key": "10.1016/S0896-6273(01)00331-2_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "1187",
      "DOI": "10.1099/0022-1317-78-5-1187",
      "article-title": "Evidence for an alternative direct route of access for the scrapie agent to the brain bypassing the spinal cord",
      "volume": "78",
      "author": "Baldauf",
      "year": "1997",
      "journal-title": "J. Gen. Virol."
    },
    {
      "key": "10.1016/S0896-6273(01)00331-2_BIB4",
      "doi-asserted-by": "crossref",
      "first-page": "1925",
      "DOI": "10.1099/0022-1317-77-8-1925",
      "article-title": "Sequential appearance and accumulation of pathognomonic markers in the central nervous system of hamsters orally infected with scrapie",
      "volume": "77",
      "author": "Beekes",
      "year": "1996",
      "journal-title": "J. Gen. Virol."
    },
    {
      "key": "10.1016/S0896-6273(01)00331-2_BIB5",
      "doi-asserted-by": "crossref",
      "first-page": "601",
      "DOI": "10.1099/0022-1317-79-3-601",
      "article-title": "Cerebral targeting indicates vagal spread of infection in hamsters fed with scrapie",
      "volume": "79",
      "author": "Beekes",
      "year": "1998",
      "journal-title": "J. Gen. Virol."
    },
    {
      "key": "10.1016/S0896-6273(01)00331-2_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "69",
      "DOI": "10.1038/37981",
      "article-title": "PrP-expressing tissue required for transfer of scrapie infectivity from spleen to brain",
      "volume": "389",
      "author": "Bl\u00e4ttler",
      "year": "1997",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0896-6273(01)00331-2_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "339",
      "DOI": "10.1038/379339a0",
      "article-title": "Normal host prion protein necessary for scrapie-induced neurotoxicity",
      "volume": "379",
      "author": "Brandner",
      "year": "1996",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0896-6273(01)00331-2_BIB8",
      "doi-asserted-by": "crossref",
      "first-page": "1339",
      "DOI": "10.1016/0092-8674(93)90360-3",
      "article-title": "Mice devoid of PrP are resistant to scrapie",
      "volume": "73",
      "author": "B\u00fceler",
      "year": "1993",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0896-6273(01)00331-2_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "5892",
      "DOI": "10.1523/JNEUROSCI.15-09-05892.1995",
      "article-title": "NGF modulates sympathetic innervation of lymphoid tissues",
      "volume": "15",
      "author": "Carlson",
      "year": "1995",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/S0896-6273(01)00331-2_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "307",
      "DOI": "10.1006/brbi.1997.0501",
      "article-title": "Catecholamine modulation of lymphocyte homing to lymphoid tissues",
      "volume": "11",
      "author": "Carlson",
      "year": "1997",
      "journal-title": "Brain Behav. Immun."
    },
    {
      "key": "10.1016/S0896-6273(01)00331-2_BIB11",
      "doi-asserted-by": "crossref",
      "first-page": "215",
      "DOI": "10.1016/0378-1135(84)90039-7",
      "article-title": "Pathogenesis of mouse scrapie",
      "volume": "9",
      "author": "Clarke",
      "year": "1984",
      "journal-title": "Vet. Microbiol."
    },
    {
      "key": "10.1016/S0896-6273(01)00331-2_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "213",
      "DOI": "10.1111/j.1365-2990.1985.tb00019.x",
      "article-title": "Pathogenesis of mouse scrapie",
      "volume": "11",
      "author": "Cole",
      "year": "1985",
      "journal-title": "Neuropathol. Appl. Neurobiol."
    },
    {
      "key": "10.1016/S0896-6273(01)00331-2_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "15",
      "DOI": "10.1093/infdis/117.1.15",
      "article-title": "Pathogenesis of scrapie virus infection in the mouse",
      "volume": "117",
      "author": "Eklund",
      "year": "1967",
      "journal-title": "J. Infect. Dis."
    },
    {
      "key": "10.1016/S0896-6273(01)00331-2_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "1941",
      "DOI": "10.1099/0022-1317-77-8-1941",
      "article-title": "Protease-resistant Prp deposition in brain and non-central nervous system tissues of a murine model of bovine spongiform encephalopathy",
      "volume": "77",
      "author": "Farquhar",
      "year": "1996",
      "journal-title": "J. Gen. Virol."
    },
    {
      "key": "10.1016/S0896-6273(01)00331-2_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "293",
      "DOI": "10.1016/0889-1591(88)90031-1",
      "article-title": "Sympathetic noradrenergic innervation of immune organs",
      "volume": "2",
      "author": "Felten",
      "year": "1988",
      "journal-title": "Brain Behav. Immun."
    },
    {
      "key": "10.1016/S0896-6273(01)00331-2_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "1255",
      "DOI": "10.1002/j.1460-2075.1996.tb00467.x",
      "article-title": "Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie",
      "volume": "15",
      "author": "Fischer",
      "year": "1996",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/S0896-6273(01)00331-2_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "479",
      "DOI": "10.1038/35044100",
      "article-title": "Binding of disease-associated prion protein to plasminogen",
      "volume": "408",
      "author": "Fischer",
      "year": "2000",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0896-6273(01)00331-2_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "613",
      "DOI": "10.1016/S1286-4579(00)00364-6",
      "article-title": "Peripheral pathogenesis of prion diseases",
      "volume": "2",
      "author": "Glatzel",
      "year": "2000",
      "journal-title": "Microbes Infect."
    },
    {
      "key": "10.1016/S0896-6273(01)00331-2_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "2813",
      "DOI": "10.1099/0022-1317-81-11-2813",
      "article-title": "PrP(C) expression in the peripheral nervous system is a determinant of prion neuroinvasion",
      "volume": "81",
      "author": "Glatzel",
      "year": "2000",
      "journal-title": "J. Gen. Virol."
    },
    {
      "key": "10.1016/S0896-6273(01)00331-2_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "442",
      "DOI": "10.1073/pnas.97.1.442",
      "article-title": "Adenoviral and adeno-associated viral transfer of genes to the peripheral nervous system",
      "volume": "97",
      "author": "Glatzel",
      "year": "2000",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0896-6273(01)00331-2_BIB21",
      "doi-asserted-by": "crossref",
      "first-page": "458",
      "DOI": "10.1007/s004010051109",
      "article-title": "Disease associated prion protein may deposit in the peripheral nervous system in human transmissible spongiform encephalopathies",
      "volume": "98",
      "author": "Hainfellner",
      "year": "1999",
      "journal-title": "Acta Neuropathol."
    },
    {
      "key": "10.1016/S0896-6273(01)00331-2_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "201",
      "DOI": "10.1016/0168-1702(89)90039-7",
      "article-title": "The role of the spleen in the neuroinvasion of scrapie in mice",
      "volume": "12",
      "author": "Kimberlin",
      "year": "1989",
      "journal-title": "Virus Res."
    },
    {
      "key": "10.1016/S0896-6273(01)00331-2_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "315",
      "DOI": "10.1016/0022-510X(83)90165-X",
      "article-title": "Pathogenesis of mouse scrapie. Evidence for direct neural spread of infection to the CNS after injection of sciatic nerve",
      "volume": "61",
      "author": "Kimberlin",
      "year": "1983",
      "journal-title": "J. Neurol. Sci."
    },
    {
      "key": "10.1016/S0896-6273(01)00331-2_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "6292",
      "DOI": "10.1128/JVI.65.11.6292-6295.1991",
      "article-title": "Abnormal isoform of prion protein accumulates in follicular dendritic cells in mice with Creutzfeldt-Jakob disease",
      "volume": "65",
      "author": "Kitamoto",
      "year": "1991",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/S0896-6273(01)00331-2_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "687",
      "DOI": "10.1038/37789",
      "article-title": "A crucial role for B cells in neuroinvasive scrapie",
      "volume": "390",
      "author": "Klein",
      "year": "1997",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0896-6273(01)00331-2_BIB26",
      "doi-asserted-by": "crossref",
      "first-page": "1429",
      "DOI": "10.1038/4022",
      "article-title": "PrP expression in B lymphocytes is not required for prion neuroinvasion",
      "volume": "4",
      "author": "Klein",
      "year": "1998",
      "journal-title": "Nat. Med."
    },
    {
      "key": "10.1016/S0896-6273(01)00331-2_BIB27",
      "doi-asserted-by": "crossref",
      "first-page": "488",
      "DOI": "10.1038/86567",
      "article-title": "Complement facilitates early prion pathogenesis",
      "volume": "7",
      "author": "Klein",
      "year": "2001",
      "journal-title": "Nat. Med."
    },
    {
      "key": "10.1016/S0896-6273(01)00331-2_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "5299",
      "DOI": "10.4049/jimmunol.162.9.5299",
      "article-title": "Suppression of antigen-specific Th2 cell-dependent IgM and IgG1 production following norepinephrine depletion in vivo",
      "volume": "162",
      "author": "Kohm",
      "year": "1999",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/S0896-6273(01)00331-2_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "4613",
      "DOI": "10.4049/jimmunol.155.10.4613",
      "article-title": "Alterations in cytokine and antibody production following chemical sympathectomy in two strains of mice",
      "volume": "155",
      "author": "Kruszewska",
      "year": "1995",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/S0896-6273(01)00331-2_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "1292",
      "DOI": "10.1128/JVI.70.2.1292-1295.1996",
      "article-title": "Immune system-dependent and -independent replication of the scrapie agent",
      "volume": "70",
      "author": "Lasmezas",
      "year": "1996",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/S0896-6273(01)00331-2_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "67",
      "DOI": "10.1016/0165-5728(94)90182-1",
      "article-title": "Sympathetic nervous system modulation of the immune system. II. Induction of lymphocyte proliferation and migration in vivo by chemical sympathectomy",
      "volume": "49",
      "author": "Madden",
      "year": "1994",
      "journal-title": "J. Neuroimmunol."
    },
    {
      "key": "10.1016/S0896-6273(01)00331-2_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "135",
      "DOI": "10.1016/S0304-3940(99)00223-2",
      "article-title": "Pathological PrP is abundant in sympathetic and sensory ganglia of hamsters fed with scrapie",
      "volume": "265",
      "author": "McBride",
      "year": "1999",
      "journal-title": "Neurosci. Lett."
    },
    {
      "key": "10.1016/S0896-6273(01)00331-2_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "1257",
      "DOI": "10.1126/science.288.5469.1257",
      "article-title": "Impaired prion replication in spleens of mice lacking functional follicular dendritic cells",
      "volume": "288",
      "author": "Montrasio",
      "year": "2000",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0896-6273(01)00331-2_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "111",
      "DOI": "10.1016/S0165-1838(96)00121-X",
      "article-title": "Methods of sympathetic degeneration and alteration",
      "volume": "62",
      "author": "Picklo",
      "year": "1997",
      "journal-title": "J. Auton. Nerv. Syst."
    },
    {
      "key": "10.1016/S0896-6273(01)00331-2_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "136",
      "DOI": "10.1126/science.6801762",
      "article-title": "Novel proteinaceous infectious particles cause scrapie",
      "volume": "216",
      "author": "Prusiner",
      "year": "1982",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0896-6273(01)00331-2_BIB36",
      "doi-asserted-by": "crossref",
      "first-page": "353",
      "DOI": "10.1002/ana.410110406",
      "article-title": "Measurement of the scrapie agent using an incubation time interval assay",
      "volume": "11",
      "author": "Prusiner",
      "year": "1982",
      "journal-title": "Ann. Neurol."
    },
    {
      "key": "10.1016/S0896-6273(01)00331-2_BIB37",
      "doi-asserted-by": "crossref",
      "first-page": "828",
      "DOI": "10.1128/JVI.74.2.828-833.2000",
      "article-title": "Entry versus blockade of brain infection following oral or intraperitoneal scrapie administration",
      "volume": "74",
      "author": "Race",
      "year": "2000",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/S0896-6273(01)00331-2_BIB38",
      "doi-asserted-by": "crossref",
      "first-page": "7620",
      "DOI": "10.1073/pnas.89.16.7620",
      "article-title": "Regional mapping of prion proteins in brain",
      "volume": "89",
      "author": "Taraboulos",
      "year": "1992",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    }
  ],
  "container-title": "Neuron",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0896627301003312?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0896627301003312?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        4,
        28
      ]
    ],
    "date-time": "2023-04-28T11:55:25Z",
    "timestamp": 1682682925000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0896627301003312"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2001,
        7
      ]
    ]
  },
  "references-count": 38,
  "journal-issue": {
    "issue": "1",
    "published-print": {
      "date-parts": [
        [
          2001,
          7
        ]
      ]
    }
  },
  "alternative-id": [
    "S0896627301003312"
  ],
  "URL": "http://dx.doi.org/10.1016/S0896-6273(01)00331-2",
  "relation": {},
  "ISSN": [
    "0896-6273"
  ],
  "subject": [],
  "container-title-short": "Neuron",
  "published": {
    "date-parts": [
      [
        2001,
        7
      ]
    ]
  }
}