DOI: 10.1016/s0896-6273(00)81127-7. Age-Dependent Emergence and Progression of a Tauopathy in Transgenic Mice Overexpressing the Shortest Human Tau Isoform

Age-Dependent Emergence and Progression of a Tauopathy in Transgenic Mice Overexpressing the Shortest Human Tau Isoform

10.1016/s0896-6273(00)81127-7

Crossref journal-article

Elsevier BV

Neuron (78)

Bibliography

Ishihara, T., Hong, M., Zhang, B., Nakagawa, Y., Lee, M. K., Trojanowski, J. Q., & Lee, V. M.-Y. (1999). Age-Dependent Emergence and Progression of a Tauopathy in Transgenic Mice Overexpressing the Shortest Human Tau Isoform. Neuron, 24(3), 751â762.

Authors 7

Takeshi Ishihara (first)
Ming Hong (additional)
Bin Zhang (additional)
Yasushi Nakagawa (additional)
Michael K Lee (additional)
John Q Trojanowski (additional)
Virginia M.-Y Lee (additional)

References 48 Referenced 468

10.1021/bi00158a027 / Biochemistry / Structure and novel exons of the human tau gene by Andreadis (1992)
10.1083/jcb.101.4.1371 / J. Cell Biol. / The distribution of tau in the mammalian central nervous system by Binder (1985)
10.1016/S1050-3862(96)00167-2 / Genet. Anal. / A vector for expressing foreign genes in the brains and hearts of transgenic mice by Borchelt (1996)
{'key': '10.1016/S0896-6273(00)81127-7_BIB4', 'first-page': '212', 'article-title': 'Regions with abundant neurofibrillary pathology in human brain exhibit a selective reduction in levels of binding-competent tau and accumulation of abnormal tau-isoforms (A68 proteins)', 'volume': '66', 'author': 'Bramblett', 'year': '1992', 'journal-title': 'Lab. Invest.'} / Lab. Invest. / Regions with abundant neurofibrillary pathology in human brain exhibit a selective reduction in levels of binding-competent tau and accumulation of abnormal tau-isoforms (A68 proteins) by Bramblett (1992)
10.1016/0896-6273(93)90057-X / Neuron / Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding by Bramblett (1993)
10.1016/S0002-9440(10)65272-8 / Am. J. Pathol. / Transgenic expression of the shortest human tau affects its compartmentalization and its phosphorylation as in the pretangle stage of Alzheimer's disease by Brion (1999)
10.1074/jbc.271.51.32789 / J. Biol. Chem. / The structural basis of monoclonal antibody Alz50's selectivity for Alzheimer's disease pathology by Carmel (1996)
10.1073/pnas.95.22.13103 / Proc. Natl. Acad. Sci. USA / Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related chromosome 17–linked neurodegenerative disorders by Clark (1998)
10.1091/mbc.3.10.1141 / Mol. Biol. Cell / Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau by Drechsel (1992)
10.1073/pnas.96.10.5598 / Proc. Natl. Acad. Sci. USA / Missense and silent tau gene mutations cause frontotemporal dementia with parkinsonism - chromosome 17 type, by affecting multiple alternative RNA splicing regulatory elements by D'Souza (1999)
10.1002/j.1460-2075.1990.tb07870.x / EMBO J. / Expression of separate isoforms of human tau protein by Goedert (1990)
10.1016/0896-6273(89)90210-9 / Neuron / Multiple isoforms of human microtubule–associated protein tau by Goedert (1989)
10.1073/pnas.90.11.5066 / Proc. Natl. Acad. Sci. USA / The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development by Goedert (1993)
10.1042/bj3010871 / Biochem. J. / Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease by Goedert (1994)
Goedert, M., Trojanowski, J.Q., and Lee, V.M.-Y. (1997). The neurofibrillary pathology of Alzheimer's disease. In The Molecular and Genetic Basis of Neurological Diseases. S.B. Prusiner et al., eds. (Boston: Butterworth-Heinemann Press), pp. 613–627. (10.1007/978-1-59259-471-9_12)
10.1002/j.1460-2075.1995.tb07116.x / EMBO J. / Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform by Goetz (1995)
10.1073/pnas.87.15.5827 / Proc. Natl. Acad. Sci. USA / A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis by Greenberg (1990)
10.1093/brain/84.4.642 / Brain / Parkinsonism dementia complex by Hirano (1961)
10.1021/bi970380+ / Biochemistry / Unique Alzheimer's disease paired helical filament specific epitopes involve double phosphorylation at specific sites by Hoffmann (1997)
10.1126/science.282.5395.1914 / Science / Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17 by Hong (1998)
10.1038/31508 / Nature / Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17 by Hutton (1998)
10.1097/00001756-199902250-00010 / Neuroreport / A distinct familial presenile dementia with a novel missense mutation in the tau gene by Iijima (1999)
10.1007/BF00687955 / Acta Neuropathologica / Spinal cord lesions in progressive supranuclear palsy by Kato (1986)
10.1016/0896-6273(88)90129-8 / Neuron / Epitopes that span the tau molecule are shared with paired helical filaments by Kosik (1988)
10.1016/0006-291X(92)91264-Q / Biochem. Biophys. Res. Commun. / Immunological and conformation characterization of a phosphorylated immunodominant epitope on the paired helical filaments found in Alzheimer's disease by Lang (1992)
10.1126/science.1899488 / Science / A68 by Lee (1991)
10.1212/WNL.40.6.975 / Neurology / Spinal cord neurofibrillary tangles of Guamanian amyotrophic lateral sclerosis and parkinsonism–dementia complex by Matsumoto (1990)
10.1016/0896-6273(94)90264-X / Neuron / Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau by Matsuo (1994)
10.1007/BF00695603 / Acta Neuropathologica / Immunohistochemical localization of neurofilament protein in neuronal degenerations by Nakazato (1984)
10.1002/jnr.490390607 / J. Neurosci. Res. / Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404 by Otvos (1994)
10.1073/pnas.82.11.3916 / Proc. Natl. Acad. Sci. USA / Paired helical filaments from Alzhemier's disease patients contain cytoskeletal components by Perry (1985)
10.1002/ana.410430617 / Ann. Neurol. / Tau is a candidate gene for chromosome 17 frontotemporal dementia by Poorkaj (1998)
10.1097/00005072-199806000-00006 / J. Neuropathol. Exp. Neurol. / The neuropathology of a chromosome 17–linked autosomal dominant parkinsonism and dementia (“pallido-ponto-nigral degeneration”) by Reed (1998)
10.1086/302256 / Am. J. Hum. Genet. / High prevalence of mutations in the microtubule-associated protein tau in a popolation study of frontotemporal dementia in the Netherlands by Rizzu (1999)
{'key': '10.1016/S0896-6273(00)81127-7_BIB35', 'first-page': '1069', 'article-title': 'Relative abundance of tau and neurofilament epitopes in hippocampal neurofibrillary tangles', 'volume': '136', 'author': 'Schmidt', 'year': '1990', 'journal-title': 'Am. J. Pathol.'} / Am. J. Pathol. / Relative abundance of tau and neurofilament epitopes in hippocampal neurofibrillary tangles by Schmidt (1990)
{'key': '10.1016/S0896-6273(00)81127-7_BIB36', 'first-page': '352', 'article-title': "Comparative epitope analysis of neuronal cytoskeletal proteins in Alzheimer's disease senile plaque neurites and neuropil threads", 'volume': '64', 'author': 'Schmidt', 'year': '1991', 'journal-title': 'Lab. Invest.'} / Lab. Invest. / Comparative epitope analysis of neuronal cytoskeletal proteins in Alzheimer's disease senile plaque neurites and neuropil threads by Schmidt (1991)
10.1074/jbc.270.32.18917 / J. Biol. Chem. / Detection of phosphorylated Ser262 in fetal tau, adult tau, and paired helical filament tau by Seubert (1995)
10.1002/ana.410250207 / Ann. Neurol. / Immunocytochemical characterization of neurofibrillary tangles in amyotrophic lateral sclerosis and parkinsonism–dementia of Guam by Shankar (1989)
10.1111/j.1750-3639.1998.tb00162.x / Brain Pathol. / Frontotemporal dementia and Parkinsonism linked to chromosome 17 by Spillantini (1998)
10.1073/pnas.95.13.7737 / Proc. Natl. Acad. Sci. USA / Mutation in the tau gene in familial multiple system tauopathy with presenile dementia by Spillantini (1998)
10.1002/jnr.490340212 / J. Neurosci. Res. / Recognition of the minimal epitope of monoclonal antibody Tau-1 depends upon the presence of a phosphate group but not its location by Szendrei (1993)
10.1007/BF00692065 / Acta Neuropathologica / Ultrastructure of neurofibrillary tangles in progressive supranuclear palsy by Tomonaga (1977)
10.1177/37.2.2492045 / J. Histochem. Cytochem. / Distribution of tau proteins in the normal human central and peripheral nervous system by Trojanowski (1989)
10.1083/jcb.129.6.1629 / J. Cell Biol. / Over-expression of the human NFM subunit in transgenic mice modifies the level of endogenous NFL and the phosphorylation state of NFH subunits by Tu (1995)
{'key': '10.1016/S0896-6273(00)81127-7_BIB45', 'first-page': '441', 'article-title': 'Oxidative stress, mutant SOD1, and neurofilament pathology in transgenic mouse models of human motor neuron disease', 'volume': '76', 'author': 'Tu', 'year': '1997', 'journal-title': 'Lab. Invest.'} / Lab. Invest. / Oxidative stress, mutant SOD1, and neurofilament pathology in transgenic mouse models of human motor neuron disease by Tu (1997)
10.1073/pnas.72.5.1858 / Proc. Natl. Acad. Sci. USA / A protein factor essential for microtubule assembly by Weingarten (1975)
10.1111/j.1471-4159.1993.tb03642.x / J. Neurochem. / Tau in paired helical filaments is functionally distinct from fetal tau by Yoshida (1993)
10.1083/jcb.139.5.1307 / J. Cell Biol. / Neurofilaments and orthograde transport are reduced in ventral root axons of transgenic mice that express human SOD1 with a G93A mutation by Zhang (1997)

Dates

Type	When
Created	21 years, 2 months ago (June 22, 2004, 10:26 a.m.)
Deposited	1 year, 4 months ago (April 22, 2024, 12:43 p.m.)
Indexed	3 days, 11 hours ago (Aug. 24, 2025, 6:56 p.m.)
Issued	25 years, 9 months ago (Nov. 1, 1999)
Published	25 years, 9 months ago (Nov. 1, 1999)
Published Print	25 years, 9 months ago (Nov. 1, 1999)

Funders 1

National Institute on Aging 10.13039/100000049
Region: Americas
gov (National government)
Labels4
1. U.S. National Institute on Aging
2. The National Institute on Aging
3. NIH NATIONAL INSTITUTE ON AGING
4. NIA

BibTeX

@article{Ishihara_1999, title={Age-Dependent Emergence and Progression of a Tauopathy in Transgenic Mice Overexpressing the Shortest Human Tau Isoform}, volume={24}, ISSN={0896-6273}, url={http://dx.doi.org/10.1016/s0896-6273(00)81127-7}, DOI={10.1016/s0896-6273(00)81127-7}, number={3}, journal={Neuron}, publisher={Elsevier BV}, author={Ishihara, Takeshi and Hong, Ming and Zhang, Bin and Nakagawa, Yasushi and Lee, Michael K and Trojanowski, John Q and Lee, Virginia M.-Y}, year={1999}, month=nov, pages={751–762} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        24
      ]
    ],
    "date-time": "2025-08-24T22:56:17Z",
    "timestamp": 1756076177223,
    "version": "3.37.3"
  },
  "reference-count": 48,
  "publisher": "Elsevier BV",
  "issue": "3",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1999,
            11,
            1
          ]
        ],
        "date-time": "1999-11-01T00:00:00Z",
        "timestamp": 941414400000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            1999,
            11,
            1
          ]
        ],
        "date-time": "1999-11-01T00:00:00Z",
        "timestamp": 941414400000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/legal/tdmrep-license"
    },
    {
      "start": {
        "date-parts": [
          [
            2013,
            7,
            17
          ]
        ],
        "date-time": "2013-07-17T00:00:00Z",
        "timestamp": 1374019200000
      },
      "content-version": "vor",
      "delay-in-days": 5007,
      "URL": "http://www.elsevier.com/open-access/userlicense/1.0/"
    }
  ],
  "funder": [
    {
      "DOI": "10.13039/100000049",
      "name": "National Institute on Aging",
      "doi-asserted-by": "publisher",
      "id": [
        {
          "id": "10.13039/100000049",
          "id-type": "DOI",
          "asserted-by": "publisher"
        }
      ]
    }
  ],
  "content-domain": {
    "domain": [
      "cell.com",
      "elsevier.com",
      "sciencedirect.com"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        1999,
        11
      ]
    ]
  },
  "DOI": "10.1016/s0896-6273(00)81127-7",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2004,
        6,
        22
      ]
    ],
    "date-time": "2004-06-22T14:26:07Z",
    "timestamp": 1087914367000
  },
  "page": "751-762",
  "update-policy": "https://doi.org/10.1016/elsevier_cm_policy",
  "source": "Crossref",
  "is-referenced-by-count": 468,
  "title": "Age-Dependent Emergence and Progression of a Tauopathy in Transgenic Mice Overexpressing the Shortest Human Tau Isoform",
  "prefix": "10.1016",
  "volume": "24",
  "author": [
    {
      "given": "Takeshi",
      "family": "Ishihara",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Ming",
      "family": "Hong",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Bin",
      "family": "Zhang",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Yasushi",
      "family": "Nakagawa",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Michael K",
      "family": "Lee",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "John Q",
      "family": "Trojanowski",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Virginia M.-Y",
      "family": "Lee",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB1",
      "doi-asserted-by": "crossref",
      "first-page": "10626",
      "DOI": "10.1021/bi00158a027",
      "article-title": "Structure and novel exons of the human tau gene",
      "volume": "31",
      "author": "Andreadis",
      "year": "1992",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "1371",
      "DOI": "10.1083/jcb.101.4.1371",
      "article-title": "The distribution of tau in the mammalian central nervous system",
      "volume": "101",
      "author": "Binder",
      "year": "1985",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "159",
      "DOI": "10.1016/S1050-3862(96)00167-2",
      "article-title": "A vector for expressing foreign genes in the brains and hearts of transgenic mice",
      "volume": "13",
      "author": "Borchelt",
      "year": "1996",
      "journal-title": "Genet. Anal."
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB4",
      "first-page": "212",
      "article-title": "Regions with abundant neurofibrillary pathology in human brain exhibit a selective reduction in levels of binding-competent tau and accumulation of abnormal tau-isoforms (A68 proteins)",
      "volume": "66",
      "author": "Bramblett",
      "year": "1992",
      "journal-title": "Lab. Invest."
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB5",
      "doi-asserted-by": "crossref",
      "first-page": "1089",
      "DOI": "10.1016/0896-6273(93)90057-X",
      "article-title": "Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding",
      "volume": "10",
      "author": "Bramblett",
      "year": "1993",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "255",
      "DOI": "10.1016/S0002-9440(10)65272-8",
      "article-title": "Transgenic expression of the shortest human tau affects its compartmentalization and its phosphorylation as in the pretangle stage of Alzheimer's disease",
      "volume": "154",
      "author": "Brion",
      "year": "1999",
      "journal-title": "Am. J. Pathol."
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "32789",
      "DOI": "10.1074/jbc.271.51.32789",
      "article-title": "The structural basis of monoclonal antibody Alz50's selectivity for Alzheimer's disease pathology",
      "volume": "271",
      "author": "Carmel",
      "year": "1996",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB8",
      "doi-asserted-by": "crossref",
      "first-page": "13103",
      "DOI": "10.1073/pnas.95.22.13103",
      "article-title": "Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related chromosome 17\u2013linked neurodegenerative disorders",
      "volume": "95",
      "author": "Clark",
      "year": "1998",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "1141",
      "DOI": "10.1091/mbc.3.10.1141",
      "article-title": "Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau",
      "volume": "3",
      "author": "Drechsel",
      "year": "1992",
      "journal-title": "Mol. Biol. Cell"
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "5598",
      "DOI": "10.1073/pnas.96.10.5598",
      "article-title": "Missense and silent tau gene mutations cause frontotemporal dementia with parkinsonism - chromosome 17 type, by affecting multiple alternative RNA splicing regulatory elements",
      "volume": "96",
      "author": "D'Souza",
      "year": "1999",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB11",
      "doi-asserted-by": "crossref",
      "first-page": "4225",
      "DOI": "10.1002/j.1460-2075.1990.tb07870.x",
      "article-title": "Expression of separate isoforms of human tau protein",
      "volume": "9",
      "author": "Goedert",
      "year": "1990",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "519",
      "DOI": "10.1016/0896-6273(89)90210-9",
      "article-title": "Multiple isoforms of human microtubule\u2013associated protein tau",
      "volume": "3",
      "author": "Goedert",
      "year": "1989",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "5066",
      "DOI": "10.1073/pnas.90.11.5066",
      "article-title": "The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development",
      "volume": "90",
      "author": "Goedert",
      "year": "1993",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "871",
      "DOI": "10.1042/bj3010871",
      "article-title": "Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease",
      "volume": "301",
      "author": "Goedert",
      "year": "1994",
      "journal-title": "Biochem. J."
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB15",
      "doi-asserted-by": "crossref",
      "unstructured": "Goedert, M., Trojanowski, J.Q., and Lee, V.M.-Y. (1997). The neurofibrillary pathology of Alzheimer's disease. In The Molecular and Genetic Basis of Neurological Diseases. S.B. Prusiner et al., eds. (Boston: Butterworth-Heinemann Press), pp. 613\u2013627.",
      "DOI": "10.1007/978-1-59259-471-9_12"
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "1304",
      "DOI": "10.1002/j.1460-2075.1995.tb07116.x",
      "article-title": "Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform",
      "volume": "14",
      "author": "Goetz",
      "year": "1995",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "5827",
      "DOI": "10.1073/pnas.87.15.5827",
      "article-title": "A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis",
      "volume": "87",
      "author": "Greenberg",
      "year": "1990",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "642",
      "DOI": "10.1093/brain/84.4.642",
      "article-title": "Parkinsonism dementia complex",
      "volume": "84",
      "author": "Hirano",
      "year": "1961",
      "journal-title": "Brain"
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "8114",
      "DOI": "10.1021/bi970380+",
      "article-title": "Unique Alzheimer's disease paired helical filament specific epitopes involve double phosphorylation at specific sites",
      "volume": "36",
      "author": "Hoffmann",
      "year": "1997",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "1914",
      "DOI": "10.1126/science.282.5395.1914",
      "article-title": "Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17",
      "volume": "282",
      "author": "Hong",
      "year": "1998",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB21",
      "doi-asserted-by": "crossref",
      "first-page": "702",
      "DOI": "10.1038/31508",
      "article-title": "Association of missense and 5\u2032-splice-site mutations in tau with the inherited dementia FTDP-17",
      "volume": "393",
      "author": "Hutton",
      "year": "1998",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "497",
      "DOI": "10.1097/00001756-199902250-00010",
      "article-title": "A distinct familial presenile dementia with a novel missense mutation in the tau gene",
      "volume": "10",
      "author": "Iijima",
      "year": "1999",
      "journal-title": "Neuroreport"
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "11",
      "DOI": "10.1007/BF00687955",
      "article-title": "Spinal cord lesions in progressive supranuclear palsy",
      "volume": "71",
      "author": "Kato",
      "year": "1986",
      "journal-title": "Acta Neuropathologica"
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "817",
      "DOI": "10.1016/0896-6273(88)90129-8",
      "article-title": "Epitopes that span the tau molecule are shared with paired helical filaments",
      "volume": "1",
      "author": "Kosik",
      "year": "1988",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "783",
      "DOI": "10.1016/0006-291X(92)91264-Q",
      "article-title": "Immunological and conformation characterization of a phosphorylated immunodominant epitope on the paired helical filaments found in Alzheimer's disease",
      "volume": "187",
      "author": "Lang",
      "year": "1992",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB26",
      "doi-asserted-by": "crossref",
      "first-page": "675",
      "DOI": "10.1126/science.1899488",
      "article-title": "A68",
      "volume": "251",
      "author": "Lee",
      "year": "1991",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB27",
      "doi-asserted-by": "crossref",
      "first-page": "975",
      "DOI": "10.1212/WNL.40.6.975",
      "article-title": "Spinal cord neurofibrillary tangles of Guamanian amyotrophic lateral sclerosis and parkinsonism\u2013dementia complex",
      "volume": "40",
      "author": "Matsumoto",
      "year": "1990",
      "journal-title": "Neurology"
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "989",
      "DOI": "10.1016/0896-6273(94)90264-X",
      "article-title": "Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau",
      "volume": "13",
      "author": "Matsuo",
      "year": "1994",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "30",
      "DOI": "10.1007/BF00695603",
      "article-title": "Immunohistochemical localization of neurofilament protein in neuronal degenerations",
      "volume": "64",
      "author": "Nakazato",
      "year": "1984",
      "journal-title": "Acta Neuropathologica"
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "669",
      "DOI": "10.1002/jnr.490390607",
      "article-title": "Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404",
      "volume": "39",
      "author": "Otvos",
      "year": "1994",
      "journal-title": "J. Neurosci. Res."
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "3916",
      "DOI": "10.1073/pnas.82.11.3916",
      "article-title": "Paired helical filaments from Alzhemier's disease patients contain cytoskeletal components",
      "volume": "82",
      "author": "Perry",
      "year": "1985",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "815",
      "DOI": "10.1002/ana.410430617",
      "article-title": "Tau is a candidate gene for chromosome 17 frontotemporal dementia",
      "volume": "43",
      "author": "Poorkaj",
      "year": "1998",
      "journal-title": "Ann. Neurol."
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "588",
      "DOI": "10.1097/00005072-199806000-00006",
      "article-title": "The neuropathology of a chromosome 17\u2013linked autosomal dominant parkinsonism and dementia (\u201cpallido-ponto-nigral degeneration\u201d)",
      "volume": "57",
      "author": "Reed",
      "year": "1998",
      "journal-title": "J. Neuropathol. Exp. Neurol."
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "414",
      "DOI": "10.1086/302256",
      "article-title": "High prevalence of mutations in the microtubule-associated protein tau in a popolation study of frontotemporal dementia in the Netherlands",
      "volume": "64",
      "author": "Rizzu",
      "year": "1999",
      "journal-title": "Am. J. Hum. Genet."
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB35",
      "first-page": "1069",
      "article-title": "Relative abundance of tau and neurofilament epitopes in hippocampal neurofibrillary tangles",
      "volume": "136",
      "author": "Schmidt",
      "year": "1990",
      "journal-title": "Am. J. Pathol."
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB36",
      "first-page": "352",
      "article-title": "Comparative epitope analysis of neuronal cytoskeletal proteins in Alzheimer's disease senile plaque neurites and neuropil threads",
      "volume": "64",
      "author": "Schmidt",
      "year": "1991",
      "journal-title": "Lab. Invest."
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB37",
      "doi-asserted-by": "crossref",
      "first-page": "18917",
      "DOI": "10.1074/jbc.270.32.18917",
      "article-title": "Detection of phosphorylated Ser262 in fetal tau, adult tau, and paired helical filament tau",
      "volume": "270",
      "author": "Seubert",
      "year": "1995",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB38",
      "doi-asserted-by": "crossref",
      "first-page": "146",
      "DOI": "10.1002/ana.410250207",
      "article-title": "Immunocytochemical characterization of neurofibrillary tangles in amyotrophic lateral sclerosis and parkinsonism\u2013dementia of Guam",
      "volume": "25",
      "author": "Shankar",
      "year": "1989",
      "journal-title": "Ann. Neurol."
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB39",
      "doi-asserted-by": "crossref",
      "first-page": "387",
      "DOI": "10.1111/j.1750-3639.1998.tb00162.x",
      "article-title": "Frontotemporal dementia and Parkinsonism linked to chromosome 17",
      "volume": "8",
      "author": "Spillantini",
      "year": "1998",
      "journal-title": "Brain Pathol."
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "7737",
      "DOI": "10.1073/pnas.95.13.7737",
      "article-title": "Mutation in the tau gene in familial multiple system tauopathy with presenile dementia",
      "volume": "95",
      "author": "Spillantini",
      "year": "1998",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB41",
      "doi-asserted-by": "crossref",
      "first-page": "243",
      "DOI": "10.1002/jnr.490340212",
      "article-title": "Recognition of the minimal epitope of monoclonal antibody Tau-1 depends upon the presence of a phosphate group but not its location",
      "volume": "34",
      "author": "Szendrei",
      "year": "1993",
      "journal-title": "J. Neurosci. Res."
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB42",
      "doi-asserted-by": "crossref",
      "first-page": "177",
      "DOI": "10.1007/BF00692065",
      "article-title": "Ultrastructure of neurofibrillary tangles in progressive supranuclear palsy",
      "volume": "37",
      "author": "Tomonaga",
      "year": "1977",
      "journal-title": "Acta Neuropathologica"
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB43",
      "doi-asserted-by": "crossref",
      "first-page": "209",
      "DOI": "10.1177/37.2.2492045",
      "article-title": "Distribution of tau proteins in the normal human central and peripheral nervous system",
      "volume": "37",
      "author": "Trojanowski",
      "year": "1989",
      "journal-title": "J. Histochem. Cytochem."
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB44",
      "doi-asserted-by": "crossref",
      "first-page": "1629",
      "DOI": "10.1083/jcb.129.6.1629",
      "article-title": "Over-expression of the human NFM subunit in transgenic mice modifies the level of endogenous NFL and the phosphorylation state of NFH subunits",
      "volume": "129",
      "author": "Tu",
      "year": "1995",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB45",
      "first-page": "441",
      "article-title": "Oxidative stress, mutant SOD1, and neurofilament pathology in transgenic mouse models of human motor neuron disease",
      "volume": "76",
      "author": "Tu",
      "year": "1997",
      "journal-title": "Lab. Invest."
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB46",
      "doi-asserted-by": "crossref",
      "first-page": "1858",
      "DOI": "10.1073/pnas.72.5.1858",
      "article-title": "A protein factor essential for microtubule assembly",
      "volume": "72",
      "author": "Weingarten",
      "year": "1975",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB47",
      "doi-asserted-by": "crossref",
      "first-page": "1183",
      "DOI": "10.1111/j.1471-4159.1993.tb03642.x",
      "article-title": "Tau in paired helical filaments is functionally distinct from fetal tau",
      "volume": "61",
      "author": "Yoshida",
      "year": "1993",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "10.1016/S0896-6273(00)81127-7_BIB48",
      "doi-asserted-by": "crossref",
      "first-page": "1307",
      "DOI": "10.1083/jcb.139.5.1307",
      "article-title": "Neurofilaments and orthograde transport are reduced in ventral root axons of transgenic mice that express human SOD1 with a G93A mutation",
      "volume": "139",
      "author": "Zhang",
      "year": "1997",
      "journal-title": "J. Cell Biol."
    }
  ],
  "container-title": "Neuron",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0896627300811277?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0896627300811277?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2024,
        4,
        22
      ]
    ],
    "date-time": "2024-04-22T16:43:27Z",
    "timestamp": 1713804207000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0896627300811277"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1999,
        11
      ]
    ]
  },
  "references-count": 48,
  "journal-issue": {
    "issue": "3",
    "published-print": {
      "date-parts": [
        [
          1999,
          11
        ]
      ]
    }
  },
  "alternative-id": [
    "S0896627300811277"
  ],
  "URL": "http://dx.doi.org/10.1016/S0896-6273(00)81127-7",
  "relation": {},
  "ISSN": [
    "0896-6273"
  ],
  "subject": [],
  "container-title-short": "Neuron",
  "published": {
    "date-parts": [
      [
        1999,
        11
      ]
    ]
  },
  "assertion": [
    {
      "value": "Elsevier",
      "name": "publisher",
      "label": "This article is maintained by"
    },
    {
      "value": "Age-Dependent Emergence and Progression of a Tauopathy in Transgenic Mice Overexpressing the Shortest Human Tau Isoform",
      "name": "articletitle",
      "label": "Article Title"
    },
    {
      "value": "Neuron",
      "name": "journaltitle",
      "label": "Journal Title"
    },
    {
      "value": "https://doi.org/10.1016/S0896-6273(00)81127-7",
      "name": "articlelink",
      "label": "CrossRef DOI link to publisher maintained version"
    },
    {
      "value": "converted-article",
      "name": "content_type",
      "label": "Content Type"
    },
    {
      "value": "Copyright \u00a9 1999 Cell Press. Published by Elsevier Inc. All rights reserved.",
      "name": "copyright",
      "label": "Copyright"
    }
  ]
}