DOI: 10.1016/s0896-6273(00)80909-5. Formation of Temporal Memory Requires NMDA Receptors within CA1 Pyramidal Neurons

Formation of Temporal Memory Requires NMDA Receptors within CA1 Pyramidal Neurons

10.1016/s0896-6273(00)80909-5

Crossref journal-article

Elsevier BV

Neuron (78)

Bibliography

Huerta, P. T., Sun, L. D., Wilson, M. A., & Tonegawa, S. (2000). Formation of Temporal Memory Requires NMDA Receptors within CA1 Pyramidal Neurons. Neuron, 25(2), 473â480.

Authors 4

Patricio T Huerta (first)
Linus D Sun (additional)
Matthew A Wilson (additional)
Susumu Tonegawa (additional)

References 40 Referenced 272

10.1126/science.1257783 / Science / Neuronal substrates of classical conditioning in the hippocampus by Berger (1976)
10.1016/S0163-1047(05)80065-2 / Behav. Neural Biol. / Memory for spatial location as a function of temporal lag in rats by Chiba (1994)
{'year': '1993', 'series-title': 'Memory, Amnesia and the Hippocampal System', 'author': 'Cohen', 'key': '10.1016/S0896-6273(00)80909-5_BIB3'} / Memory, Amnesia and the Hippocampal System by Cohen (1993)
10.1016/0166-2236(94)90106-6 / Trends Neurosci. / Neurotransmission in the rat amygdala related to fear and anxiety by Davis (1994)
10.1016/S0896-6273(00)80773-4 / Neuron / The hippocampus, memory, and place cells by Eichenbaum (1999)
10.3758/BF03205285 / Anim. Learn. Behav. / Factors governing one-trial contextual conditioning by Fanselow (1990)
10.1016/S0149-7634(99)00016-0 / Neurosci. Biobehav. Rev. / The neuroanatomical and neurochemical basis of conditioned fear by Fendt (1999)
10.1006/nlme.1998.3859 / Neurobiol. Learn. Mem. / Memory for duration by Jackson (1998)
10.1016/0163-1047(93)90664-4 / Behav. Neural Biol. / On the role of the hippocampus in learning and memory in the rat by Jarrard (1993)
10.1016/S0166-2236(96)10081-3 / Trends Neurosci. / Cerebellar circuits and synaptic mechanisms involved in classical eyeblink conditioning by Kim (1997)
10.1016/0166-4328(93)90091-4 / Behav. Brain Res. / Emotional memory systems in the brain by LeDoux (1993)
10.1016/0028-3932(93)90034-W / Neuropsychologia / Determinants of non-spatial working memory deficits in rats given intraventricular infusions of the NMDA antagonist AP5 by Lyford (1993)
{'key': '10.1016/S0896-6273(00)80909-5_BIB13', 'first-page': '23', 'article-title': 'Simple memory', 'volume': '262', 'author': 'Marr', 'year': '1971', 'journal-title': 'Proc. R. Soc. Lond. B Biol. Sci.'} / Proc. R. Soc. Lond. B Biol. Sci. / Simple memory by Marr (1971)
10.1152/jn.1997.78.2.1030 / J. Neurophysiol. / Sequence of single neuron changes in CA1 hippocampus of rabbits during acquisition of trace eyeblink conditioned responses by McEchon (1997)
10.1002/(SICI)1098-1063(1998)8:6<638::AID-HIPO6>3.0.CO;2-Q / Hippocampus / Hippocampectomy disrupts auditory trace fear conditioning and contextual fear conditioning in the rat by McEchon (1998)
10.1016/S0092-8674(00)81828-0 / Cell / Impaired hippocampal representation of space in CA1-specific NMDAR1 knockout mice by McHugh (1996)
10.1016/0166-2236(87)90011-7 / Trends Neurosci. / Hippocampal synaptic enhancement and information storage within a distributed memory system by McNaughton (1987)
10.1037/0735-7044.98.1.3 / Behav. Neurosci. / Hippocampus, time, and memory by Meck (1984)
10.1038/297681a0 / Nature / Place navigation impaired in rats with hippocampal lesions by Morris (1982)
10.1038/319774a0 / Nature / Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5 by Morris (1986)
10.1523/JNEUROSCI.07-07-01951.1987 / J. Neurosci. / The effects of changes in the environment on the spatial firing of hippocampal complex-spike cells by Muller (1987)
10.1002/hipo.450010302 / Hippocampus / The hippocampus and space revisited by Nadel (1991)
10.1002/(SICI)1098-1063(1999)9:4<352::AID-HIPO3>3.0.CO;2-1 / Hippocampus / Do hippocampal pyramidal cells signal non-spatial as well as spatial information? by O'Keefe (1999)
{'year': '1978', 'series-title': 'The Hippocampus as a Cognitive Map', 'author': "O'Keefe", 'key': '10.1016/S0896-6273(00)80909-5_BIB24'} / The Hippocampus as a Cognitive Map by O'Keefe (1978)
10.1007/BF00255230 / Exp. Brain Res. / Single unit activity in the rat hippocampus during a spatial memory task by O'Keefe (1987)
{'key': '10.1016/S0896-6273(00)80909-5_BIB26', 'series-title': 'The Hippocampus—New Vistas', 'article-title': 'Mnemonic functions of the hippocampus', 'author': 'Olton', 'year': '1989'} / The Hippocampus—New Vistas / Mnemonic functions of the hippocampus by Olton (1989)
10.1101/lm.1.1.34 / Learn. Mem. / Lesions of the dorsal hippocampal formation interfere with background but not foreground contextual fear conditioning by Phillips (1994)
10.1523/JNEUROSCI.10-06-02008.1990 / J. Neurosci. / The firing of hippocampal place cells in the dark depends on the rat's recent experience by Quirk (1990)
10.1002/(SICI)1098-1063(1996)6:6<735::AID-HIPO15>3.0.CO;2-1 / Hippocampus / Memory for places by Recce (1996)
10.1016/S0166-4328(98)00039-4 / Behav. Brain Res. / Generalization of fear responses in C57BL/6N mice subjected to one-trial foreground contextual fear conditioning by Radulovic (1998)
10.1017/S0140525X00001291 / Behav. Brain Sci. / Associations across time by Rawlins (1985)
10.1038/37601 / Nature / Fear conditioning induces associative long-term potentiation in the amygdala by Rogan (1997)
10.1523/JNEUROSCI.16-08-02809.1996 / J. Neurosci. / Hippocampal and neocortical cell assemblies encode memory processes for different types of stimuli in the rat by Sakurai (1996)
{'year': '1994', 'series-title': 'Memory Systems 1994', 'author': 'Schacter', 'key': '10.1016/S0896-6273(00)80909-5_BIB34'} / Memory Systems 1994 by Schacter (1994)
{'year': '1999', 'series-title': 'Memory', 'author': 'Squire', 'key': '10.1016/S0896-6273(00)80909-5_BIB35'} / Memory by Squire (1999)
10.1101/SQB.1996.061.01.025 / Cold Spring Harbor Symp. Quant. Biol. / Hippocampal CA1-region-restricted knockout of NMDAR1 gene disrupts synaptic plasticity, place fields, and spatial learning by Tonegawa (1996)
10.1016/S0092-8674(00)81827-9 / Cell / The essential role of hippocampal CA1 NMDA receptor–dependent synaptic plasticity in spatial memory by Tsien (1996)
10.1126/science.277.5324.376 / Science / Differential effects of early hippocampal pathology on episodic and semantic memory by Vargha-Khadem (1997)
10.1126/science.8351520 / Science / Dynamics of the hippocampal ensemble code for space by Wilson (1993)
10.1038/17605 / Nature / The global record of memory in hippocampal neuronal activity by Wood (1999)

Dates

Type	When
Created	21 years, 2 months ago (June 22, 2004, 10:26 a.m.)
Deposited	1 year, 4 months ago (April 22, 2024, 12:42 p.m.)
Indexed	3 weeks, 4 days ago (Aug. 7, 2025, 4:46 p.m.)
Issued	25 years, 7 months ago (Feb. 1, 2000)
Published	25 years, 7 months ago (Feb. 1, 2000)
Published Print	25 years, 7 months ago (Feb. 1, 2000)

Funders 1

National Institutes of Health 10.13039/100000002
Region: Americas
gov (National government)
Labels3
1. Institutos Nacionales de la Salud
2. US National Institutes of Health
3. NIH

BibTeX

@article{Huerta_2000, title={Formation of Temporal Memory Requires NMDA Receptors within CA1 Pyramidal Neurons}, volume={25}, ISSN={0896-6273}, url={http://dx.doi.org/10.1016/s0896-6273(00)80909-5}, DOI={10.1016/s0896-6273(00)80909-5}, number={2}, journal={Neuron}, publisher={Elsevier BV}, author={Huerta, Patricio T and Sun, Linus D and Wilson, Matthew A and Tonegawa, Susumu}, year={2000}, month=feb, pages={473–480} }

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      "author": "Rawlins",
      "year": "1985",
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      "author": "Sakurai",
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      "volume": "61",
      "author": "Tonegawa",
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      "volume": "27",
      "author": "Tsien",
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      "author": "Vargha-Khadem",
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      "author": "Wilson",
      "year": "1993",
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