DOI: 10.1016/s0896-6273(00)80543-7. Point Mutation in trkB Causes Loss of NT4-Dependent Neurons without Major Effects on Diverse BDNF Responses

Point Mutation in trkB Causes Loss of NT4-Dependent Neurons without Major Effects on Diverse BDNF Responses

10.1016/s0896-6273(00)80543-7

Crossref journal-article

Elsevier BV

Neuron (78)

Bibliography

Minichiello, L., Casagranda, F., Tatche, R. S., Stucky, C. L., Postigo, A., Lewin, G. R., Davies, A. M., & Klein, R. (1998). Point Mutation in trkB Causes Loss of NT4-Dependent Neurons without Major Effects on Diverse BDNF Responses. Neuron, 21(2), 335â345.

Authors 8

Liliana Minichiello (first)
Franca Casagranda (additional)
Rosa Soler Tatche (additional)
Cheryl L Stucky (additional)
Antonio Postigo (additional)
Gary R Lewin (additional)
Alun M Davies (additional)
Rüdiger Klein (additional)

References 64 Referenced 158

10.1002/ar.1090940210 / Anat. Rec / Estimation of nuclear populations from microtome sections by Abercrombie (1946)
10.1016/S0896-6273(00)80047-1 / Neuron / Specific subsets of cutaneous mechanoreceptors require neurotrophin-3 after peripheral target innervation by Airaksinen (1996)
10.1523/JNEUROSCI.17-10-03623.1997 / J. Neurosci / TrkB signaling is required for postnatal survival of CNS neurons and protects hippocampal and motor neurons from axotomy-induced cell death by Alcantara (1997)
10.1038/39885 / Nature / Anterograde transport of brain-derived neurotrophic factor and its role in the brain by Altar (1997)
10.1016/0955-0674(95)80022-0 / Curr. Opin. Cell Biol / Neurotrophic factors and their receptors by Barbacid (1995)
10.1111/j.1432-1033.1995.084_c.x / Eur. J. Biochem / Phosphotyrosine residues in the nerve growth factor receptor (Trk-A) by Baxter (1995)
10.1016/S0896-6273(00)80348-7 / Neuron / Blockade of endogenous ligands of TrkB inhibits formation of ocular dominance columns by Cabelli (1997)
10.1038/242 / Nat. Neurosci / A role for BDNF in mechanosensation by Carroll (1998)
10.1016/S0896-6273(00)80259-7 / Neuron / Neurotrophins live or let die by Carter (1997)
10.1038/378192a0 / Nature / Effects of brain-derived neurotrophic factor on optic axon branching and remodeling in vivo by Cohen-Cory (1995)
10.1016/0896-6273(92)90028-C / Neuron / Cellular targets and trophic functions of neurotrophin-3 in the developing rat hippocampus by Collazo (1992)
10.1016/S0959-4388(97)80128-6 / Curr. Opin. Neurobiol / Neurotrophin switching by Davies (1997)
10.1016/S0960-9822(06)00016-9 / Curr. Biol / Neurotrophins by Davies (1997)
10.1523/JNEUROSCI.13-11-04961.1993 / J. Neurosci / NT-4/5 is a mammalian-specific survival factor for distinct populations of sensory neurons by Davies (1993)
10.1016/0896-6273(93)90069-4 / Neuron / p75-deficent trigeminal neurons have an altered response to NGF but not to other neurotrophins by Davies (1993)
10.1002/j.1460-2075.1995.tb00127.x / EMBO J / Developmental changes in NT3 signaling via TrkA and TrkB in embryonic neurons by Davies (1995)
{'key': '10.1016/S0896-6273(00)80543-7_BIB17', 'series-title': 'Cell Biology', 'article-title': 'Culturing hippocampal neurons and astrocytes from fetal rodent brain', 'author': 'de Hoop', 'year': '1998'} / Cell Biology / Culturing hippocampal neurons and astrocytes from fetal rodent brain by de Hoop (1998)
10.1073/pnas.93.12.6191 / Proc. Natl. Acad. Sci. USA / Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice by Dymecki (1996)
{'key': '10.1016/S0896-6273(00)80543-7_BIB19', 'article-title': 'Using Flp-recombinase to characterize expansion of Wnt1-expressing neural progenitors in the mouse', 'volume': 'in press', 'author': 'Dymecki', 'year': '1998', 'journal-title': 'Dev. Biol'} / Dev. Biol / Using Flp-recombinase to characterize expansion of Wnt1-expressing neural progenitors in the mouse by Dymecki (1998)
10.1523/JNEUROSCI.17-22-08667.1997 / J. Neurosci / Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 complement and cooperate with each other sequentially during visceral neuron development by ElShamy (1997)
10.1523/JNEUROSCI.16-17-05361.1996 / J. Neurosci / Mice lacking brain-derived neurotrophic factor exhibit visceral sensory neuron loss distinct from mice lacking NT4 and display a severe developmental deficit in control of breathing by Erickson (1996)
10.1016/S0896-6273(00)80395-5 / Neuron / CREB by Finkbeiner (1997)
10.1073/pnas.91.18.8607 / Proc. Natl. Acad. Sci. USA / Reversal of spatial memory impairments in aged rats by nerve growth factor and neurotrophins 3 and 4/5 but not by brain-derived neurotrophic factor by Fischer (1994)
10.1016/0092-8674(94)90394-8 / Cell / CREB by Frank (1994)
10.1016/S0092-8674(00)81883-8 / Cell / PI3K by Franke (1997)
10.1016/S0166-2236(96)01007-7 / Trends Neurosci / The role of neurotrophic factors in regulating the development of inner ear innervation by Fritzsch (1997)
10.1016/0959-4388(95)80062-X / Curr. Opin. Neurobiol / Early events in neurotrophin signaling via Trk and p75 receptors by Greene (1995)
10.1016/S0021-9258(18)43823-9 / J. Biol. Chem / Identification of in vivo brain-derived neurotrophic factor-stimulated autophosphorylation sites on the TrkB receptor tyrosine kinase by site-directed mutagenesis by Guiton (1994)
10.1016/S0959-4388(96)80010-9 / Curr. Opin. Neurobiol / Role of neurotrophic factors in neuronal development by Henderson (1996)
10.1523/JNEUROSCI.14-01-00335.1994 / J. Neurosci / Overlapping and distinct actions of the neurotrophins BDNF, NT-3, and NT-4/5 on cultured dopaminergic and GABAergic neurons of the ventral mesencephalon by Hyman (1994)
10.1126/science.276.5317.1428 / Science / Lamina-specific connectivity in the brain by Inoue (1997)
10.1016/0092-8674(94)90377-8 / Cell / Targeted disruption of the BDNF gene perturbs brain and sensory neuron develoment but not motor neuron development by Jones (1994)
10.1016/S0955-0674(97)80065-8 / Curr. Opin. Cell Biol / Signal transduction by the neurotrophin receptors by Kaplan (1997)
10.1126/science.7527937 / Science / An alternative to SH2 domains for binding tyrosine-phosphorylated proteins by Kavanaugh (1994)
10.1002/j.1460-2075.1989.tb08545.x / EMBO J / trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development by Klein (1989)
10.1016/S0092-8674(05)80088-1 / Cell / Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death by Klein (1993)
10.1152/jn.1997.78.4.1841 / J. Neurophysiol / Receptive properties of mouse cutaneous sensory neurons by Koltzenburg (1997)
10.1016/S0092-8674(00)80252-4 / Cell / A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway by Kouhara (1997)
10.1146/annurev.ne.19.030196.001445 / Annu. Rev. Neurosci / Physiology of the neurotrophins by Lewin (1996)
10.1016/0166-2236(94)90139-2 / Trends Neurosci / Neurotrophins and brain insults by Lindvall (1994)
10.1016/0092-8674(95)90401-8 / Cell / Specificity of receptor tyrosine kinase signaling by Marshall (1995)
10.1016/S0896-6273(00)80075-6 / Neuron / GABAergic stimulation regulates the phenotype of hippocampal interneurons through the regulation of brain-derived neurotrophic factor by Marty (1996)
10.1101/gad.10.22.2849 / Genes Dev / TrkB and TrkC neurotrophin receptors cooperate in promoting survival of hippocampal and cerebellar granule neurons by Minichiello (1996)
10.1242/dev.121.12.4067 / Development / Differential effects of combined trk receptor mutations on dorsal root ganglion and inner ear sensory neurons by Minichiello (1995)
{'key': '10.1016/S0896-6273(00)80543-7_BIB45', 'first-page': '1111', 'article-title': 'N-Shc', 'volume': '13', 'author': 'Nakamura', 'year': '1996', 'journal-title': 'Oncogene'} / Oncogene / N-Shc by Nakamura (1996)
10.1073/pnas.93.7.2729 / Proc. Natl. Acad. Sci. USA / A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain by O’Bryan (1996)
10.1016/S0021-9258(19)49410-6 / J. Biol. Chem / Identification of Trk binding sites for SHC and phosphatidylinositol 3′-kinase and formation of a multimeric signaling complex by Obermeier (1993)
10.1002/j.1460-2075.1994.tb06421.x / EMBO J / Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLCγ by Obermeier (1994)
10.1016/0092-8674(94)90318-2 / Cell / A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family by Ponzetto (1994)
10.1038/378189a0 / Nature / NT-4-mediated rescue of lateral geniculate neurons from effects of monocular deprivation by Riddle (1995)
10.1038/367170a0 / Nature / Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion by Schnell (1994)
10.1016/S0896-6273(00)80938-1 / Neuron / Abnormal cerebellar development and foliation in BDNF−/− mice reveals a role for neurotrophins in CNS patterning by Schwartz (1997)
10.1146/annurev.ne.19.030196.002335 / Annu. Rev. Neurosci / Intracellular signaling pathways activated by neurotrophic factors by Segal (1996)
10.1016/S0960-9822(06)00319-8 / Curr. Biol / Neurotrophins by Shieh (1997)
10.1038/368246a0 / Nature / Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene by Smeyne (1994)
10.1016/0896-6273(94)90223-2 / Neuron / Trk receptors use redundant signal transduction pathways involving SHC and PLC-γ1 to mediate NGF responses by Stephens (1994)
{'key': '10.1016/S0896-6273(00)80543-7_BIB57', 'article-title': 'Neurotrophin-4 (NT-4) is required for the survival of a subclass of hair follicle receptors', 'volume': 'in press', 'author': 'Stucky', 'year': '1998', 'journal-title': 'J. Neurosci'} / J. Neurosci / Neurotrophin-4 (NT-4) is required for the survival of a subclass of hair follicle receptors by Stucky (1998)
10.1006/mcne.1996.0054 / Mol. Cell. Neurosci / Dissociation of NGF induced signal transduction from neurite elongation by expression of a mutant adaptor protein v-Crk in PC12 cells by Teng (1996)
10.1126/science.270.5236.593 / Science / Neurotrophins and neuronal plasticity by Thoenen (1995)
10.1128/MCB.15.7.3644 / Mol. Cell. Biol / Mitogen-activated protein kinase activation is insufficient for growth factor receptor-mediated PC12 cell differentiation by Vaillancourt (1995)
10.1016/S0960-9822(95)00081-9 / Curr. Biol / A conserved amino-terminal Shc domain binds to phosphotyrosine motifs in activated receptors and phosphopeptides by van der Geer (1995)
10.1016/0896-6273(95)90068-3 / Neuron / Functions of basic fibroblast growth factor and neurotrophins in the differentiation of hippocampal neurons by Vicario-Abejon (1995)
10.1074/jbc.272.48.30334 / J. Biol. Chem / Insulin receptor substrate (IRS)-1 and IRS-2 are tyrosine-phosphorylated and associated with phosphatidylinositol 3-kinase in response to brain-derived neurotrophic factor in cultured cerebral cortical neurons by Yamada (1997)
10.1038/33451 / Nature / Rap1 mediates sustained MAP kinase activation induced by nerve growth factor by York (1998)

Dates

Type	When
Created	21 years, 2 months ago (June 11, 2004, 8:28 a.m.)
Deposited	4 years, 2 months ago (June 23, 2021, 2:49 a.m.)
Indexed	1 month, 4 weeks ago (July 6, 2025, 1:44 p.m.)
Issued	27 years, 1 month ago (Aug. 1, 1998)
Published	27 years, 1 month ago (Aug. 1, 1998)
Published Print	27 years, 1 month ago (Aug. 1, 1998)

Funders 0

None

BibTeX

@article{Minichiello_1998, title={Point Mutation in trkB Causes Loss of NT4-Dependent Neurons without Major Effects on Diverse BDNF Responses}, volume={21}, ISSN={0896-6273}, url={http://dx.doi.org/10.1016/s0896-6273(00)80543-7}, DOI={10.1016/s0896-6273(00)80543-7}, number={2}, journal={Neuron}, publisher={Elsevier BV}, author={Minichiello, Liliana and Casagranda, Franca and Tatche, Rosa Soler and Stucky, Cheryl L and Postigo, Antonio and Lewin, Gary R and Davies, Alun M and Klein, Rüdiger}, year={1998}, month=aug, pages={335–345} }

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      "article-title": "Neurotrophic factors and their receptors",
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      "volume": "234",
      "author": "Baxter",
      "year": "1995",
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      "author": "Fritzsch",
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      "volume": "5",
      "author": "Greene",
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      "volume": "269",
      "author": "Guiton",
      "year": "1994",
      "journal-title": "J. Biol. Chem"
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      "article-title": "Role of neurotrophic factors in neuronal development",
      "volume": "6",
      "author": "Henderson",
      "year": "1996",
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      "DOI": "10.1523/JNEUROSCI.14-01-00335.1994",
      "article-title": "Overlapping and distinct actions of the neurotrophins BDNF, NT-3, and NT-4/5 on cultured dopaminergic and GABAergic neurons of the ventral mesencephalon",
      "volume": "14",
      "author": "Hyman",
      "year": "1994",
      "journal-title": "J. Neurosci"
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    {
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      "first-page": "1428",
      "DOI": "10.1126/science.276.5317.1428",
      "article-title": "Lamina-specific connectivity in the brain",
      "volume": "276",
      "author": "Inoue",
      "year": "1997",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0896-6273(00)80543-7_BIB32",
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      "DOI": "10.1016/0092-8674(94)90377-8",
      "article-title": "Targeted disruption of the BDNF gene perturbs brain and sensory neuron develoment but not motor neuron development",
      "volume": "76",
      "author": "Jones",
      "year": "1994",
      "journal-title": "Cell"
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      "first-page": "213",
      "DOI": "10.1016/S0955-0674(97)80065-8",
      "article-title": "Signal transduction by the neurotrophin receptors",
      "volume": "9",
      "author": "Kaplan",
      "year": "1997",
      "journal-title": "Curr. Opin. Cell Biol"
    },
    {
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      "first-page": "1862",
      "DOI": "10.1126/science.7527937",
      "article-title": "An alternative to SH2 domains for binding tyrosine-phosphorylated proteins",
      "volume": "266",
      "author": "Kavanaugh",
      "year": "1994",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0896-6273(00)80543-7_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "3701",
      "DOI": "10.1002/j.1460-2075.1989.tb08545.x",
      "article-title": "trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development",
      "volume": "8",
      "author": "Klein",
      "year": "1989",
      "journal-title": "EMBO J"
    },
    {
      "key": "10.1016/S0896-6273(00)80543-7_BIB36",
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      "first-page": "113",
      "DOI": "10.1016/S0092-8674(05)80088-1",
      "article-title": "Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death",
      "volume": "75",
      "author": "Klein",
      "year": "1993",
      "journal-title": "Cell"
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      "first-page": "1841",
      "DOI": "10.1152/jn.1997.78.4.1841",
      "article-title": "Receptive properties of mouse cutaneous sensory neurons",
      "volume": "78",
      "author": "Koltzenburg",
      "year": "1997",
      "journal-title": "J. Neurophysiol"
    },
    {
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      "article-title": "A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway",
      "volume": "89",
      "author": "Kouhara",
      "year": "1997",
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      "article-title": "Physiology of the neurotrophins",
      "volume": "19",
      "author": "Lewin",
      "year": "1996",
      "journal-title": "Annu. Rev. Neurosci"
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      "first-page": "490",
      "DOI": "10.1016/0166-2236(94)90139-2",
      "article-title": "Neurotrophins and brain insults",
      "volume": "17",
      "author": "Lindvall",
      "year": "1994",
      "journal-title": "Trends Neurosci"
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    {
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      "DOI": "10.1016/0092-8674(95)90401-8",
      "article-title": "Specificity of receptor tyrosine kinase signaling",
      "volume": "80",
      "author": "Marshall",
      "year": "1995",
      "journal-title": "Cell"
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    {
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      "article-title": "GABAergic stimulation regulates the phenotype of hippocampal interneurons through the regulation of brain-derived neurotrophic factor",
      "volume": "16",
      "author": "Marty",
      "year": "1996",
      "journal-title": "Neuron"
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      "first-page": "2849",
      "DOI": "10.1101/gad.10.22.2849",
      "article-title": "TrkB and TrkC neurotrophin receptors cooperate in promoting survival of hippocampal and cerebellar granule neurons",
      "volume": "10",
      "author": "Minichiello",
      "year": "1996",
      "journal-title": "Genes Dev"
    },
    {
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      "first-page": "4067",
      "DOI": "10.1242/dev.121.12.4067",
      "article-title": "Differential effects of combined trk receptor mutations on dorsal root ganglion and inner ear sensory neurons",
      "volume": "121",
      "author": "Minichiello",
      "year": "1995",
      "journal-title": "Development"
    },
    {
      "key": "10.1016/S0896-6273(00)80543-7_BIB45",
      "first-page": "1111",
      "article-title": "N-Shc",
      "volume": "13",
      "author": "Nakamura",
      "year": "1996",
      "journal-title": "Oncogene"
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    {
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      "first-page": "2729",
      "DOI": "10.1073/pnas.93.7.2729",
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      "volume": "93",
      "author": "O\u2019Bryan",
      "year": "1996",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
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      "first-page": "22963",
      "DOI": "10.1016/S0021-9258(19)49410-6",
      "article-title": "Identification of Trk binding sites for SHC and phosphatidylinositol 3\u2032-kinase and formation of a multimeric signaling complex",
      "volume": "268",
      "author": "Obermeier",
      "year": "1993",
      "journal-title": "J. Biol. Chem"
    },
    {
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      "first-page": "1585",
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      "article-title": "Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLC\u03b3",
      "volume": "13",
      "author": "Obermeier",
      "year": "1994",
      "journal-title": "EMBO J"
    },
    {
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      "first-page": "261",
      "DOI": "10.1016/0092-8674(94)90318-2",
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      "volume": "77",
      "author": "Ponzetto",
      "year": "1994",
      "journal-title": "Cell"
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    {
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      "first-page": "189",
      "DOI": "10.1038/378189a0",
      "article-title": "NT-4-mediated rescue of lateral geniculate neurons from effects of monocular deprivation",
      "volume": "378",
      "author": "Riddle",
      "year": "1995",
      "journal-title": "Nature"
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    {
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      "first-page": "170",
      "DOI": "10.1038/367170a0",
      "article-title": "Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion",
      "volume": "367",
      "author": "Schnell",
      "year": "1994",
      "journal-title": "Nature"
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      "article-title": "Abnormal cerebellar development and foliation in BDNF\u2212/\u2212 mice reveals a role for neurotrophins in CNS patterning",
      "volume": "19",
      "author": "Schwartz",
      "year": "1997",
      "journal-title": "Neuron"
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      "first-page": "463",
      "DOI": "10.1146/annurev.ne.19.030196.002335",
      "article-title": "Intracellular signaling pathways activated by neurotrophic factors",
      "volume": "19",
      "author": "Segal",
      "year": "1996",
      "journal-title": "Annu. Rev. Neurosci"
    },
    {
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      "first-page": "R627",
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      "volume": "7",
      "author": "Shieh",
      "year": "1997",
      "journal-title": "Curr. Biol"
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      "first-page": "246",
      "DOI": "10.1038/368246a0",
      "article-title": "Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene",
      "volume": "368",
      "author": "Smeyne",
      "year": "1994",
      "journal-title": "Nature"
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      "volume": "12",
      "author": "Stephens",
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      "article-title": "Neurotrophin-4 (NT-4) is required for the survival of a subclass of hair follicle receptors",
      "volume": "in press",
      "author": "Stucky",
      "year": "1998",
      "journal-title": "J. Neurosci"
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      "volume": "8",
      "author": "Teng",
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      "author": "Thoenen",
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      "volume": "15",
      "author": "Vaillancourt",
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      "volume": "5",
      "author": "van der Geer",
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      "volume": "272",
      "author": "Yamada",
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