DOI: 10.1016/s0891-5849(99)00102-1. Oxidative damage and protection by antioxidants in the frontal cortex of Alzheimer’s disease is related to the apolipoprotein E genotype

Oxidative damage and protection by antioxidants in the frontal cortex of Alzheimer’s disease is related to the apolipoprotein E genotype

10.1016/s0891-5849(99)00102-1

Crossref journal-article

Elsevier BV

Free Radical Biology and Medicine (78)

Bibliography

Ramassamy, C., Averill, D., Beffert, U., Bastianetto, S., Theroux, L., Lussier-Cacan, S., Cohn, J. S., Christen, Y., Davignon, J., Quirion, R., & Poirier, J. (1999). Oxidative damage and protection by antioxidants in the frontal cortex of Alzheimerâs disease is related to the apolipoprotein E genotype. Free Radical Biology and Medicine, 27(5â6), 544â553.

Authors 11

Charles Ramassamy (first)
Diana Averill (additional)
Uwe Beffert (additional)
Stephane Bastianetto (additional)
Louise Theroux (additional)
Suzanne Lussier-Cacan (additional)
Jeffrey S Cohn (additional)
Yves Christen (additional)
Jean Davignon (additional)
Rémi Quirion (additional)
Judes Poirier (additional)

References 62 Referenced 186

10.1038/353844a0 / Nature / Early-onset Alzheimer’s disease caused by mutations at codon 717 of the β-amyloid precursor protein gene by Chartier-Harlin (1991)
10.1038/360672a0 / Nature / Mutations of the beta-amyloid precursor protein in familial Alzheimer’s disease increases beta-protein production by Citron (1992)
10.1126/science.8346443 / Science / Gene dose of apolipoprotein E. type 4 allele and the risk of Alzheimer’s disease in late onset families by Corder (1993)
10.1016/0140-6736(93)91705-Q / Lancet / Apolipoprotein E polymorphism and Alzheimer’s disease by Poirier (1993)
10.1073/pnas.90.5.1977 / Proc. Natl. Acad. Sci. USA / Apolipoprotein E by Strittmater (1993)
10.1126/science.7638622 / Science / Candidate gene for the chromosome 1 familial Alzheimer’s disease locus by Levy-Lahad (1995)
10.1038/375754a0 / Nature / Cloning of a gene bearing missence mutations in early-onset familial Alzheimer’s disease by Sherrington (1995)
{'key': '10.1016/S0891-5849(99)00102-1_BIB8', 'first-page': '339', 'article-title': 'Genetics of the apolipoprotein E system in man', 'volume': '32', 'author': 'Utterman', 'year': '1980', 'journal-title': 'Am. J. Hum. Genet.'} / Am. J. Hum. Genet. / Genetics of the apolipoprotein E system in man by Utterman (1980)
10.1016/S0021-9258(18)34702-1 / J. Biol. Chem. / Human apolipoprotein E. The complete amino acid sequence by Rall (1982)
10.1016/S0021-9258(18)34954-8 / J. Biol. Chem. / Abnormal lipoprotein receptor-binding activity of the human E apolipoprotein due to cysteine-arginine interchange at a single site by Weisgraber (1982)
10.1073/pnas.91.23.11183 / Proc. Natl. Acad. Sci. USA / Isoform specific interactions of apolipoprotein E with microtubule-associated protein tau by Strittmatter (1994)
10.1046/j.1471-4159.1998.70041458.x / J. Neurochem. / Beta-amyloid peptides increases the binding and internalization of apolipoprotein E to hippocampal neurons by Beffert (1998)
10.1523/JNEUROSCI.18-01-00195.1998 / J. Neurosci. / Isoform effect of apolipoprotein E on cell survival and beta-amyloid-induced toxicity in rat hippocampal pyramidal neuronal cultures by Jordan (1998)
10.1016/0166-2236(94)90156-2 / Trends Neurosci. / Apolipoprotein E in animal model of CNS injury and in Alzheimer’s disease by Poirier (1994)
10.1046/j.1471-4159.1997.69041661.x / J. Neurochem. / Transbilayer distribution of cholesterol is modified in brain synaptic plasma membranes of knockout mice deficient in the low-density lipoprotein receptor, apolipoprotein E, or both proteins by Igbavboa (1997)
10.1038/ng0996-55 / Nature Genet. / Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity insults and β-amyloid peptides by Miyata (1996)
10.1006/bbrc.1994.1883 / Biochem. Biophys. Res. Commun. / Increased plasma and lipoprotein and lipid peroxidation in APOE-deficient mice by Hayek (1994)
10.1016/S0891-5849(96)00629-6 / Free Radic. Biol. Med. / Oxidative stress hypothesis in Alzheimer’s disease by Markesbery (1997)
10.1111/j.1471-4159.1990.tb08858.x / J. Neurochem. / Autopsy samples of Alzheimer’s cortex show increased peroxidation in vitro by Subbarao (1990)
10.1007/BF00965146 / Neurochem. Res. / Evidence of anoxidative challenge in the Alzheimer’s brain by Balazs (1994)
10.1073/pnas.91.16.7787 / Proc. Natl. Acad. Sci. USA / Glycated tau protein in Alzheimer’s disease by Yan (1994)
10.1212/WNL.45.8.1594 / Neurology / Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer’s disease by Lovell (1995)
10.1046/j.1471-4159.1997.68052092.x / J. Neurochem. / 4-HNE-derived advanced lipid peroxidation end products are increased in Alzheimer’s disease by Sayre (1997)
10.1073/pnas.91.12.5710 / Proc. Natl. Acad. Sci. USA / Advanced Maillard reaction end products are associated with Alzheimer’s disease pathology by Smith (1994)
10.1073/pnas.91.11.4766 / Proc. Natl. Acad. Sci. USA / Advanced glycation end products contribute to amyloidosis in Alzheimer’s disease by Vitek (1994)
10.1038/382120b0 / Nature / Oxidative damage in Alzheimer’s disease by Smith (1996)
10.1016/0092-8674(94)90131-7 / Cell / Hydrogen peroxide mediates amyloid β protein toxicity by Behl (1994)
10.1073/pnas.91.8.3270 / Proc. Natl. Acad. Sci. USA / A model for β-amyloid aggregation and neurotoxicity based on free radical generation by the peptide by Hensley (1994)
10.1046/j.1471-4159.1995.65020710.x / J. Neurochem. / Transferrin and iron in normal, Alzheimer’s disease, and Parkinson’s disease brain regions by Loeffler (1995)
10.1016/0304-3940(94)11787-J / Neurosci. Lett. / Free radical formation in autopsy samples of Alzheimer and control cortex by Zhou (1995)
10.1001/archneur.1985.04060100083029 / Arch. Neurol. / Diagnosis of Alzheimer’s disease by Khachaturian (1985)
10.1161/01.ATV.16.1.149 / Arterioscler. Thromb. Vasc. Biol. / Plasma concentration of apolipoprotein E in intermediate-sized remnant-like lipoproteins in normolipidemic and hyperlipidemic subjects by Cohn (1996)
10.1016/0003-2697(79)90738-3 / Anal. Biochem. / Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction by Okhawa (1979)
10.1016/0003-2697(89)90101-2 / Anal. Biochem. / Protein measurement using bicinchoninic acid by Brown (1989)
10.1016/S0076-6879(84)05016-3 / Methods Enzymol. / Catalase in vitro by Aebi (1984)
{'key': '10.1016/S0891-5849(99)00102-1_BIB36', 'first-page': '158', 'article-title': 'Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase', 'volume': '70', 'author': 'Paglia', 'year': '1967', 'journal-title': 'J. Lab. Clin. Med.'} / J. Lab. Clin. Med. / Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase by Paglia (1967)
{'key': '10.1016/S0891-5849(99)00102-1_BIB37', 'series-title': 'Handbook of methods for oxygen radical research', 'first-page': '317', 'author': 'Anderson', 'year': '1989'} / Handbook of methods for oxygen radical research by Anderson (1989)
10.1016/0304-4157(83)90001-1 / Biochim. Biophys. Acta. / Lipoprotein receptors and cholesterol homeostasis by Mahley (1983)
10.1126/science.3283935 / Science / Apolipoprotein E by Mahley (1988)
10.1016/0169-328X(95)00097-C / Brain Res. / Association of apolipoprotein E and apolipoprotein J (clusterin) in Alzheimer’s disease by Bertrand (1995)
10.1046/j.1471-4159.1997.68052061.x / J. Neurochem. / An assessment of oxidative damage to proteins, lipids and DNA in brain from patients with Alzheimer’s disease by Lyras (1997)
10.1006/exnr.1997.6750 / Exp. Neurol. / Increased peroxidation and reduced antioxidant enzyme activity in Alzheimer’s disease by Marcus (1998)
10.1097/00005072-199708000-00004 / J. Neuropath. Exp. Neurol. / 4-hydroxy-2-nonenal pyrrole adducts in human neurodegenerative disease by Montine (1997)
{'key': '10.1016/S0891-5849(99)00102-1_BIB44', 'first-page': '437', 'article-title': 'Immunohistochemical detection of 4-hydroxy-2-nonenal adducts in Alzheimer’s disease is associated with inheritance of APOE4', 'volume': '150', 'author': 'Montine', 'year': '1997', 'journal-title': 'Am. J. Pathol.'} / Am. J. Pathol. / Immunohistochemical detection of 4-hydroxy-2-nonenal adducts in Alzheimer’s disease is associated with inheritance of APOE4 by Montine (1997)
10.1007/s004390050600 / Hum. Genet. / Association of transferrin C2 allele with late-onset Alzheimer’s disease by Namekata (1997)
10.1073/pnas.94.18.9866 / Proc. Natl. Acad. Sci. USA / Iron accumulation in Alzheimer’s disease is a source of redox-generated free radicals by Smith (1997)
{'key': '10.1016/S0891-5849(99)00102-1_BIB47', 'first-page': '3986', 'article-title': 'Genomic instability and catalase gene amplification induced by chronic exposure to oxidative stress', 'volume': '58', 'author': 'Hunt', 'year': '1998', 'journal-title': 'Cancer Res.'} / Cancer Res. / Genomic instability and catalase gene amplification induced by chronic exposure to oxidative stress by Hunt (1998)
10.1046/j.1471-4159.1995.64031216.x / J. Neurochem. / Decreased catalase activity but unchanged superoxide dismutase activity in brains of patients with dementia of Alzheimer’s type by Gsell (1995)
10.1016/0006-8993(94)91670-5 / Brain Res. / Selective increase in lipid peroxidation in the inferior temporal cortex in Alzheimer’s disease by Palmer (1994)
10.1016/0024-3205(96)00334-7 / Life Sci. / Evidence against the involvement of reactive oxygen species in the pathogenesis of neuronal death in Down’s syndrome and Alzheimer’s disease by Hayn (1996)
10.1093/clinchem/38.9.1792 / Clin. Chem. / Simple method for quantifying alpha-tocopherol in low-density lipoproteins and in high-density lipoproteins by Carcelain (1992)
10.1046/j.1471-4159.1996.66062429.x / J. Neurochem. / Brain expression of apolipoproteins E, J, and A-I in Alzheimer’s disease by Harr (1996)
10.1007/BF00225071 / Hum. Genet. / Apolipoprotein E (APOE) polymorphism and its influence on apoE concentrations in the cerebrospinal fluid in Finnish patients with Alzheimer’s disease by Lehtimaki (1995)
10.1016/S0304-3940(97)13477-2 / Neurosci. Lett. / Levels of cerebrospinal fluid apolipoprotein E in patients with Alzheimer’s disease and healthy controls by Hahne (1997)
10.1001/jama.278.16.1327 / JAMA / A placebo-controlled, double blind, randomized trial of an extract of Ginkgo biloba for dementia by LeBars (1997)
10.1016/S0022-3956(97)00022-8 / J. Psychiat. Res. / Clinical efficacy of Ginkgo biloba specila extract EGb 761 in dementia of the Alzheimer type by Maurer (1997)
10.1016/0006-8993(87)90807-9 / Brain Res. / Effects of dehydroepiandrosterone and its sulfate on brain tissue in culture and on memory in mice by Roberts (1987)
{'key': '10.1016/S0891-5849(99)00102-1_BIB58', 'first-page': '1455', 'article-title': 'Preparation and definition of Ginkgo biloba extract', 'volume': '15', 'author': 'Drieu', 'year': '1986', 'journal-title': 'Presse Med.'} / Presse Med. / Preparation and definition of Ginkgo biloba extract by Drieu (1986)
Robel, P.; Beaulieu, E. E. Neurosteroids: biosynthesis and function. Critical Review in Neurobiology 9:383–394; 1995.
{'key': '10.1016/S0891-5849(99)00102-1_BIB60', 'first-page': 'S125', 'article-title': 'Dehydroepiandrosterone metabolism', 'volume': '150', 'author': 'Longcope', 'year': '1996', 'journal-title': 'J. Endocrinol.'} / J. Endocrinol. / Dehydroepiandrosterone metabolism by Longcope (1996)
10.1073/pnas.92.26.12260 / Proc. Natl. Acad. Sci. USA / Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer’s disease by Poirier (1995)
10.1016/S0140-6736(97)80089-X / Lancet / APOE genotyping and response to drug treatment in Alzheimer’s disease by Richard (1997)

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 12:08 p.m.)
Deposited	4 years, 3 months ago (May 8, 2021, 6:22 a.m.)
Indexed	2 months ago (July 2, 2025, 2:45 p.m.)
Issued	26 years ago (Sept. 1, 1999)
Published	26 years ago (Sept. 1, 1999)
Published Print	26 years ago (Sept. 1, 1999)

Funders 0

None

BibTeX

@article{Ramassamy_1999, title={Oxidative damage and protection by antioxidants in the frontal cortex of Alzheimer’s disease is related to the apolipoprotein E genotype}, volume={27}, ISSN={0891-5849}, url={http://dx.doi.org/10.1016/s0891-5849(99)00102-1}, DOI={10.1016/s0891-5849(99)00102-1}, number={5–6}, journal={Free Radical Biology and Medicine}, publisher={Elsevier BV}, author={Ramassamy, Charles and Averill, Diana and Beffert, Uwe and Bastianetto, Stephane and Theroux, Louise and Lussier-Cacan, Suzanne and Cohn, Jeffrey S and Christen, Yves and Davignon, Jean and Quirion, Rémi and Poirier, Judes}, year={1999}, month=sep, pages={544–553} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        2
      ]
    ],
    "date-time": "2025-07-02T18:45:06Z",
    "timestamp": 1751481906320
  },
  "reference-count": 62,
  "publisher": "Elsevier BV",
  "issue": "5-6",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1999,
            9,
            1
          ]
        ],
        "date-time": "1999-09-01T00:00:00Z",
        "timestamp": 936144000000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1999,
        9
      ]
    ]
  },
  "DOI": "10.1016/s0891-5849(99)00102-1",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        7,
        25
      ]
    ],
    "date-time": "2002-07-25T16:08:36Z",
    "timestamp": 1027613316000
  },
  "page": "544-553",
  "source": "Crossref",
  "is-referenced-by-count": 186,
  "title": "Oxidative damage and protection by antioxidants in the frontal cortex of Alzheimer\u2019s disease is related to the apolipoprotein E genotype",
  "prefix": "10.1016",
  "volume": "27",
  "author": [
    {
      "given": "Charles",
      "family": "Ramassamy",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Diana",
      "family": "Averill",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Uwe",
      "family": "Beffert",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Stephane",
      "family": "Bastianetto",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Louise",
      "family": "Theroux",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Suzanne",
      "family": "Lussier-Cacan",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Jeffrey S",
      "family": "Cohn",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Yves",
      "family": "Christen",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Jean",
      "family": "Davignon",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "R\u00e9mi",
      "family": "Quirion",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Judes",
      "family": "Poirier",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB1",
      "doi-asserted-by": "crossref",
      "first-page": "844",
      "DOI": "10.1038/353844a0",
      "article-title": "Early-onset Alzheimer\u2019s disease caused by mutations at codon 717 of the \u03b2-amyloid precursor protein gene",
      "volume": "353",
      "author": "Chartier-Harlin",
      "year": "1991",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "672",
      "DOI": "10.1038/360672a0",
      "article-title": "Mutations of the beta-amyloid precursor protein in familial Alzheimer\u2019s disease increases beta-protein production",
      "volume": "360",
      "author": "Citron",
      "year": "1992",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "921",
      "DOI": "10.1126/science.8346443",
      "article-title": "Gene dose of apolipoprotein E. type 4 allele and the risk of Alzheimer\u2019s disease in late onset families",
      "volume": "261",
      "author": "Corder",
      "year": "1993",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB4",
      "doi-asserted-by": "crossref",
      "first-page": "697",
      "DOI": "10.1016/0140-6736(93)91705-Q",
      "article-title": "Apolipoprotein E polymorphism and Alzheimer\u2019s disease",
      "volume": "342",
      "author": "Poirier",
      "year": "1993",
      "journal-title": "Lancet"
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB5",
      "doi-asserted-by": "crossref",
      "first-page": "1977",
      "DOI": "10.1073/pnas.90.5.1977",
      "article-title": "Apolipoprotein E",
      "volume": "90",
      "author": "Strittmater",
      "year": "1993",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "973",
      "DOI": "10.1126/science.7638622",
      "article-title": "Candidate gene for the chromosome 1 familial Alzheimer\u2019s disease locus",
      "volume": "269",
      "author": "Levy-Lahad",
      "year": "1995",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "754",
      "DOI": "10.1038/375754a0",
      "article-title": "Cloning of a gene bearing missence mutations in early-onset familial Alzheimer\u2019s disease",
      "volume": "375",
      "author": "Sherrington",
      "year": "1995",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB8",
      "first-page": "339",
      "article-title": "Genetics of the apolipoprotein E system in man",
      "volume": "32",
      "author": "Utterman",
      "year": "1980",
      "journal-title": "Am. J. Hum. Genet."
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "4171",
      "DOI": "10.1016/S0021-9258(18)34702-1",
      "article-title": "Human apolipoprotein E. The complete amino acid sequence",
      "volume": "257",
      "author": "Rall",
      "year": "1982",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "2518",
      "DOI": "10.1016/S0021-9258(18)34954-8",
      "article-title": "Abnormal lipoprotein receptor-binding activity of the human E apolipoprotein due to cysteine-arginine interchange at a single site",
      "volume": "257",
      "author": "Weisgraber",
      "year": "1982",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB11",
      "doi-asserted-by": "crossref",
      "first-page": "11183",
      "DOI": "10.1073/pnas.91.23.11183",
      "article-title": "Isoform specific interactions of apolipoprotein E with microtubule-associated protein tau",
      "volume": "91",
      "author": "Strittmatter",
      "year": "1994",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "1458",
      "DOI": "10.1046/j.1471-4159.1998.70041458.x",
      "article-title": "Beta-amyloid peptides increases the binding and internalization of apolipoprotein E to hippocampal neurons",
      "volume": "70",
      "author": "Beffert",
      "year": "1998",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1523/JNEUROSCI.18-01-00195.1998",
      "article-title": "Isoform effect of apolipoprotein E on cell survival and beta-amyloid-induced toxicity in rat hippocampal pyramidal neuronal cultures",
      "volume": "18",
      "author": "Jordan",
      "year": "1998",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "525",
      "DOI": "10.1016/0166-2236(94)90156-2",
      "article-title": "Apolipoprotein E in animal model of CNS injury and in Alzheimer\u2019s disease",
      "volume": "17",
      "author": "Poirier",
      "year": "1994",
      "journal-title": "Trends Neurosci."
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "1661",
      "DOI": "10.1046/j.1471-4159.1997.69041661.x",
      "article-title": "Transbilayer distribution of cholesterol is modified in brain synaptic plasma membranes of knockout mice deficient in the low-density lipoprotein receptor, apolipoprotein E, or both proteins",
      "volume": "69",
      "author": "Igbavboa",
      "year": "1997",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "55",
      "DOI": "10.1038/ng0996-55",
      "article-title": "Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity insults and \u03b2-amyloid peptides",
      "volume": "14",
      "author": "Miyata",
      "year": "1996",
      "journal-title": "Nature Genet."
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "1567",
      "DOI": "10.1006/bbrc.1994.1883",
      "article-title": "Increased plasma and lipoprotein and lipid peroxidation in APOE-deficient mice",
      "volume": "201",
      "author": "Hayek",
      "year": "1994",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "134",
      "DOI": "10.1016/S0891-5849(96)00629-6",
      "article-title": "Oxidative stress hypothesis in Alzheimer\u2019s disease",
      "volume": "23",
      "author": "Markesbery",
      "year": "1997",
      "journal-title": "Free Radic. Biol. Med."
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "342",
      "DOI": "10.1111/j.1471-4159.1990.tb08858.x",
      "article-title": "Autopsy samples of Alzheimer\u2019s cortex show increased peroxidation in vitro",
      "volume": "55",
      "author": "Subbarao",
      "year": "1990",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "1131",
      "DOI": "10.1007/BF00965146",
      "article-title": "Evidence of anoxidative challenge in the Alzheimer\u2019s brain",
      "volume": "19",
      "author": "Balazs",
      "year": "1994",
      "journal-title": "Neurochem. Res."
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB21",
      "doi-asserted-by": "crossref",
      "first-page": "7787",
      "DOI": "10.1073/pnas.91.16.7787",
      "article-title": "Glycated tau protein in Alzheimer\u2019s disease",
      "volume": "91",
      "author": "Yan",
      "year": "1994",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "1594",
      "DOI": "10.1212/WNL.45.8.1594",
      "article-title": "Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer\u2019s disease",
      "volume": "45",
      "author": "Lovell",
      "year": "1995",
      "journal-title": "Neurology"
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "2092",
      "DOI": "10.1046/j.1471-4159.1997.68052092.x",
      "article-title": "4-HNE-derived advanced lipid peroxidation end products are increased in Alzheimer\u2019s disease",
      "volume": "68",
      "author": "Sayre",
      "year": "1997",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "5710",
      "DOI": "10.1073/pnas.91.12.5710",
      "article-title": "Advanced Maillard reaction end products are associated with Alzheimer\u2019s disease pathology",
      "volume": "91",
      "author": "Smith",
      "year": "1994",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "4766",
      "DOI": "10.1073/pnas.91.11.4766",
      "article-title": "Advanced glycation end products contribute to amyloidosis in Alzheimer\u2019s disease",
      "volume": "91",
      "author": "Vitek",
      "year": "1994",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB26",
      "doi-asserted-by": "crossref",
      "first-page": "120",
      "DOI": "10.1038/382120b0",
      "article-title": "Oxidative damage in Alzheimer\u2019s disease",
      "volume": "382",
      "author": "Smith",
      "year": "1996",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB27",
      "doi-asserted-by": "crossref",
      "first-page": "817",
      "DOI": "10.1016/0092-8674(94)90131-7",
      "article-title": "Hydrogen peroxide mediates amyloid \u03b2 protein toxicity",
      "volume": "77",
      "author": "Behl",
      "year": "1994",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "3270",
      "DOI": "10.1073/pnas.91.8.3270",
      "article-title": "A model for \u03b2-amyloid aggregation and neurotoxicity based on free radical generation by the peptide",
      "volume": "91",
      "author": "Hensley",
      "year": "1994",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "710",
      "DOI": "10.1046/j.1471-4159.1995.65020710.x",
      "article-title": "Transferrin and iron in normal, Alzheimer\u2019s disease, and Parkinson\u2019s disease brain regions",
      "volume": "65",
      "author": "Loeffler",
      "year": "1995",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "89",
      "DOI": "10.1016/0304-3940(94)11787-J",
      "article-title": "Free radical formation in autopsy samples of Alzheimer and control cortex",
      "volume": "195",
      "author": "Zhou",
      "year": "1995",
      "journal-title": "Neurosci. Lett."
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "1097",
      "DOI": "10.1001/archneur.1985.04060100083029",
      "article-title": "Diagnosis of Alzheimer\u2019s disease",
      "volume": "42",
      "author": "Khachaturian",
      "year": "1985",
      "journal-title": "Arch. Neurol."
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "149",
      "DOI": "10.1161/01.ATV.16.1.149",
      "article-title": "Plasma concentration of apolipoprotein E in intermediate-sized remnant-like lipoproteins in normolipidemic and hyperlipidemic subjects",
      "volume": "16",
      "author": "Cohn",
      "year": "1996",
      "journal-title": "Arterioscler. Thromb. Vasc. Biol."
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "351",
      "DOI": "10.1016/0003-2697(79)90738-3",
      "article-title": "Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction",
      "volume": "95",
      "author": "Okhawa",
      "year": "1979",
      "journal-title": "Anal. Biochem."
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "136",
      "DOI": "10.1016/0003-2697(89)90101-2",
      "article-title": "Protein measurement using bicinchoninic acid",
      "volume": "189",
      "author": "Brown",
      "year": "1989",
      "journal-title": "Anal. Biochem."
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "121",
      "DOI": "10.1016/S0076-6879(84)05016-3",
      "article-title": "Catalase in vitro",
      "volume": "105",
      "author": "Aebi",
      "year": "1984",
      "journal-title": "Methods Enzymol."
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB36",
      "first-page": "158",
      "article-title": "Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase",
      "volume": "70",
      "author": "Paglia",
      "year": "1967",
      "journal-title": "J. Lab. Clin. Med."
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB37",
      "series-title": "Handbook of methods for oxygen radical research",
      "first-page": "317",
      "author": "Anderson",
      "year": "1989"
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB38",
      "doi-asserted-by": "crossref",
      "first-page": "197",
      "DOI": "10.1016/0304-4157(83)90001-1",
      "article-title": "Lipoprotein receptors and cholesterol homeostasis",
      "volume": "737",
      "author": "Mahley",
      "year": "1983",
      "journal-title": "Biochim. Biophys. Acta."
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB39",
      "doi-asserted-by": "crossref",
      "first-page": "622",
      "DOI": "10.1126/science.3283935",
      "article-title": "Apolipoprotein E",
      "volume": "240",
      "author": "Mahley",
      "year": "1988",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "174",
      "DOI": "10.1016/0169-328X(95)00097-C",
      "article-title": "Association of apolipoprotein E and apolipoprotein J (clusterin) in Alzheimer\u2019s disease",
      "volume": "33",
      "author": "Bertrand",
      "year": "1995",
      "journal-title": "Brain Res."
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB41",
      "doi-asserted-by": "crossref",
      "first-page": "2061",
      "DOI": "10.1046/j.1471-4159.1997.68052061.x",
      "article-title": "An assessment of oxidative damage to proteins, lipids and DNA in brain from patients with Alzheimer\u2019s disease",
      "volume": "68",
      "author": "Lyras",
      "year": "1997",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB42",
      "doi-asserted-by": "crossref",
      "first-page": "40",
      "DOI": "10.1006/exnr.1997.6750",
      "article-title": "Increased peroxidation and reduced antioxidant enzyme activity in Alzheimer\u2019s disease",
      "volume": "150",
      "author": "Marcus",
      "year": "1998",
      "journal-title": "Exp. Neurol."
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB43",
      "doi-asserted-by": "crossref",
      "first-page": "866",
      "DOI": "10.1097/00005072-199708000-00004",
      "article-title": "4-hydroxy-2-nonenal pyrrole adducts in human neurodegenerative disease",
      "volume": "56",
      "author": "Montine",
      "year": "1997",
      "journal-title": "J. Neuropath. Exp. Neurol."
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB44",
      "first-page": "437",
      "article-title": "Immunohistochemical detection of 4-hydroxy-2-nonenal adducts in Alzheimer\u2019s disease is associated with inheritance of APOE4",
      "volume": "150",
      "author": "Montine",
      "year": "1997",
      "journal-title": "Am. J. Pathol."
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB45",
      "doi-asserted-by": "crossref",
      "first-page": "126",
      "DOI": "10.1007/s004390050600",
      "article-title": "Association of transferrin C2 allele with late-onset Alzheimer\u2019s disease",
      "volume": "101",
      "author": "Namekata",
      "year": "1997",
      "journal-title": "Hum. Genet."
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB46",
      "doi-asserted-by": "crossref",
      "first-page": "9866",
      "DOI": "10.1073/pnas.94.18.9866",
      "article-title": "Iron accumulation in Alzheimer\u2019s disease is a source of redox-generated free radicals",
      "volume": "94",
      "author": "Smith",
      "year": "1997",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB47",
      "first-page": "3986",
      "article-title": "Genomic instability and catalase gene amplification induced by chronic exposure to oxidative stress",
      "volume": "58",
      "author": "Hunt",
      "year": "1998",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB48",
      "doi-asserted-by": "crossref",
      "first-page": "1216",
      "DOI": "10.1046/j.1471-4159.1995.64031216.x",
      "article-title": "Decreased catalase activity but unchanged superoxide dismutase activity in brains of patients with dementia of Alzheimer\u2019s type",
      "volume": "64",
      "author": "Gsell",
      "year": "1995",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB49",
      "doi-asserted-by": "crossref",
      "first-page": "338",
      "DOI": "10.1016/0006-8993(94)91670-5",
      "article-title": "Selective increase in lipid peroxidation in the inferior temporal cortex in Alzheimer\u2019s disease",
      "volume": "645",
      "author": "Palmer",
      "year": "1994",
      "journal-title": "Brain Res."
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB50",
      "doi-asserted-by": "crossref",
      "first-page": "537",
      "DOI": "10.1016/0024-3205(96)00334-7",
      "article-title": "Evidence against the involvement of reactive oxygen species in the pathogenesis of neuronal death in Down\u2019s syndrome and Alzheimer\u2019s disease",
      "volume": "59",
      "author": "Hayn",
      "year": "1996",
      "journal-title": "Life Sci."
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB51",
      "doi-asserted-by": "crossref",
      "first-page": "1792",
      "DOI": "10.1093/clinchem/38.9.1792",
      "article-title": "Simple method for quantifying alpha-tocopherol in low-density lipoproteins and in high-density lipoproteins",
      "volume": "38",
      "author": "Carcelain",
      "year": "1992",
      "journal-title": "Clin. Chem."
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB52",
      "doi-asserted-by": "crossref",
      "first-page": "2429",
      "DOI": "10.1046/j.1471-4159.1996.66062429.x",
      "article-title": "Brain expression of apolipoproteins E, J, and A-I in Alzheimer\u2019s disease",
      "volume": "66",
      "author": "Harr",
      "year": "1996",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB53",
      "doi-asserted-by": "crossref",
      "first-page": "39",
      "DOI": "10.1007/BF00225071",
      "article-title": "Apolipoprotein E (APOE) polymorphism and its influence on apoE concentrations in the cerebrospinal fluid in Finnish patients with Alzheimer\u2019s disease",
      "volume": "95",
      "author": "Lehtimaki",
      "year": "1995",
      "journal-title": "Hum. Genet."
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB54",
      "doi-asserted-by": "crossref",
      "first-page": "99",
      "DOI": "10.1016/S0304-3940(97)13477-2",
      "article-title": "Levels of cerebrospinal fluid apolipoprotein E in patients with Alzheimer\u2019s disease and healthy controls",
      "volume": "224",
      "author": "Hahne",
      "year": "1997",
      "journal-title": "Neurosci. Lett."
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB55",
      "doi-asserted-by": "crossref",
      "first-page": "1327",
      "DOI": "10.1001/jama.278.16.1327",
      "article-title": "A placebo-controlled, double blind, randomized trial of an extract of Ginkgo biloba for dementia",
      "volume": "278",
      "author": "LeBars",
      "year": "1997",
      "journal-title": "JAMA"
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB56",
      "doi-asserted-by": "crossref",
      "first-page": "645",
      "DOI": "10.1016/S0022-3956(97)00022-8",
      "article-title": "Clinical efficacy of Ginkgo biloba specila extract EGb 761 in dementia of the Alzheimer type",
      "volume": "31",
      "author": "Maurer",
      "year": "1997",
      "journal-title": "J. Psychiat. Res."
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB57",
      "doi-asserted-by": "crossref",
      "first-page": "357",
      "DOI": "10.1016/0006-8993(87)90807-9",
      "article-title": "Effects of dehydroepiandrosterone and its sulfate on brain tissue in culture and on memory in mice",
      "volume": "406",
      "author": "Roberts",
      "year": "1987",
      "journal-title": "Brain Res."
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB58",
      "first-page": "1455",
      "article-title": "Preparation and definition of Ginkgo biloba extract",
      "volume": "15",
      "author": "Drieu",
      "year": "1986",
      "journal-title": "Presse Med."
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB59",
      "unstructured": "Robel, P.; Beaulieu, E. E. Neurosteroids: biosynthesis and function. Critical Review in Neurobiology 9:383\u2013394; 1995."
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB60",
      "first-page": "S125",
      "article-title": "Dehydroepiandrosterone metabolism",
      "volume": "150",
      "author": "Longcope",
      "year": "1996",
      "journal-title": "J. Endocrinol."
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB61",
      "doi-asserted-by": "crossref",
      "first-page": "12260",
      "DOI": "10.1073/pnas.92.26.12260",
      "article-title": "Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer\u2019s disease",
      "volume": "92",
      "author": "Poirier",
      "year": "1995",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0891-5849(99)00102-1_BIB62",
      "doi-asserted-by": "crossref",
      "first-page": "539",
      "DOI": "10.1016/S0140-6736(97)80089-X",
      "article-title": "APOE genotyping and response to drug treatment in Alzheimer\u2019s disease",
      "volume": "349",
      "author": "Richard",
      "year": "1997",
      "journal-title": "Lancet"
    }
  ],
  "container-title": "Free Radical Biology and Medicine",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0891584999001021?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0891584999001021?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        5,
        8
      ]
    ],
    "date-time": "2021-05-08T10:22:06Z",
    "timestamp": 1620469326000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0891584999001021"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1999,
        9
      ]
    ]
  },
  "references-count": 62,
  "journal-issue": {
    "issue": "5-6",
    "published-print": {
      "date-parts": [
        [
          1999,
          9
        ]
      ]
    }
  },
  "alternative-id": [
    "S0891584999001021"
  ],
  "URL": "http://dx.doi.org/10.1016/S0891-5849(99)00102-1",
  "relation": {},
  "ISSN": [
    "0891-5849"
  ],
  "subject": [],
  "container-title-short": "Free Radical Biology and Medicine",
  "published": {
    "date-parts": [
      [
        1999,
        9
      ]
    ]
  }
}