DOI: 10.1016/s0378-1119(98)00178-4. Direct binding to nucleic acids by Vpr of human immunodeficiency virus type 1

Direct binding to nucleic acids by Vpr of human immunodeficiency virus type 1

10.1016/s0378-1119(98)00178-4

Crossref journal-article

Elsevier BV

Gene (78)

Bibliography

Zhang, S., Pointer, D., Singer, G., Feng, Y., Kathleen Park, & Zhao, L.-J. (1998). Direct binding to nucleic acids by Vpr of human immunodeficiency virus type 1. Gene, 212(2), 157â166.

Authors 6

Shangao Zhang (first)
Dawn Pointer (additional)
Greg Singer (additional)
Yunfeng Feng (additional)
Kathleen Park (additional)
Ling-Jun Zhao (additional)

References 41 Referenced 48

10.1006/jmbi.1996.0485 / J. Mol. Biol. / The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to TFIIB by Agostini (1996)
10.1038/nm1097-1117 / Nat. Med. / HIV-1 Vpr suppresses immune activation and apoptosis through regulation of nuclear factor kappa B by Ayyavoo (1997)
10.1006/viro.1994.1225 / Virology / Distinct effects in primary macrophages and lymphocytes of the human immunodeficiency virus type 1 accessory genes vpr, vpu, and nef: mutational analysis of a primary HIV-1 isolate by Balliet (1994)
10.1128/JVI.67.7.4409-4414.1993 / J. Virol. / Antisense phosphorothioate oligodeoxynucleotides targeted to the vpr gene inhibit human immunodeficiency virus type 1 replication in primary human macrophages by Balotta (1993)
10.1128/JVI.70.4.2324-2331.1996 / J. Virol. / Human immunodeficiency virus type 1 cell cycle control: Vpr is cytostatic and mediates G2 accumulation by a mechanism which differs from DNA damage checkpoint control by Bartz (1996)
10.1038/365666a0 / Nature / A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells by Bukrinsky (1993)
10.1128/JVI.64.6.3097-3099.1990 / J. Virol. / Human immunodeficiency virus vpr product is a virion-associated regulatory protein by Cohen (1990)
{'key': '10.1016/S0378-1119(98)00178-4_BIB8', 'first-page': '11', 'article-title': 'Identification of HIV-1 vpr product and function', 'volume': '3', 'author': 'Cohen', 'year': '1990', 'journal-title': 'J. AIDS'} / J. AIDS / Identification of HIV-1 vpr product and function by Cohen (1990)
10.1128/JVI.66.12.7517-7521.1992 / J. Virol. / An infectious molecular clone of an unusual macrophage-tropic and highly cytopathic strain of human immunodeficiency virus type 1 by Collman (1992)
10.1128/MR.56.3.375-394.1992 / Microbiol. Rev. / Mechanism of action of regulatory proteins encoded by complex retroviruses by Cullen (1992)
10.1074/jbc.272.49.30753 / J. Biol. Chem. / The zinc fingers of HIV nucleocapsid protein NCp7 direct interactions with the viral regulatory protein Vpr by de Rocquigny (1997)
10.1128/JVI.69.12.7909-7916.1995 / J. Virol. / Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr by Di Marzio (1995)
10.1002/j.1460-2075.1996.tb01003.x / EMBO J. / Nuclear import and cell cycle arrest functions of the HIV-1 Vpr protein are encoded by two separate genes in HIV-2/SIV(SM) by Fletcher (1996)
10.1128/JVI.69.4.2378-2383.1995 / J. Virol. / Progression to AIDS in the absence of a gene for vpr or vpx by Gibbs (1995)
10.1146/annurev.iy.08.040190.002321 / Annu. Rev. Immunol. / Regulation of HIV-1 gene expression by Greene (1990)
10.1073/pnas.87.20.8080 / Proc. Natl. Acad. Sci. USA / The human immunodeficiency virus type 2 vpr gene is essential for productive infection of human macrophages by Hattori (1990)
10.1128/JVI.69.11.6705-6711.1995 / J. Virol. / Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity by He (1995)
10.1073/pnas.91.15.7311 / Proc. Natl. Acad. Sci. USA / The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells by Heinzinger (1994)
10.1126/science.3388031 / Science / Isolation and characterization of a novel protein (X-ORF product) from SIV and HIV-2 by Henderson (1988)
10.1006/viro.1996.0201 / Virology / Protein stability influences human immunodeficiency virus type 2 Vpr virion incorporation and cell cycle effect by Kewalramani (1996)
10.1128/JVI.67.2.902-912.1993 / J. Virol. / Importance of vpr for infection of rhesus monkeys with simian immunodeficiency virus by Lang (1993)
10.1128/JVI.68.3.1926-1934.1994 / J. Virol. / Requirement of the Pr55gag precursor for incorporation of the Vpr product into human immunodeficiency virus type 1 viral particles by Lavallee (1994)
10.1128/JVI.69.2.1243-1252.1995 / J. Virol. / Extracellular Vpr protein increases cellular permissiveness to human immunodeficiency virus replication and reactivates virus from latency by Levy (1995)
10.1128/JVI.67.11.6542-6550.1993 / J. Virol. / Human immunodeficiency virus type 1 viral protein R localization in infected cells and virions by Lu (1993)
10.1128/JVI.71.9.6339-6347.1997 / J. Virol. / Nuclear import, virion incorporation, and cell cycle arrest/differentiation are mediated by distinct functional domains of human immunodeficiency virus type 1 Vpr by Mahalingam (1997)
10.1006/viro.1995.0079 / Virology / The carboxy-terminal domain is essential for stability and not for virion incorporation of HIV-1 Vpr into virus particles by Mahalingam (1995)
10.1128/JVI.67.12.7229-7237.1993 / J. Virol. / Incorporation of Vpr into human immunodeficiency virus type 1 virions, requirement for the p6 region of gag and mutational analysis by Paxton (1993)
10.1128/JVI.70.4.2516-2524.1996 / J. Virol. / Vpr-induced cell cycle arrest is conserved among primate lentiviruses by Planelles (1996)
10.1128/JVI.69.11.6859-6864.1995 / J. Virol. / Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B by Re (1995)
10.1128/JVI.69.2.882-888.1995 / J. Virol. / The human immunodeficiency virus type 1 vpr gene prevents cell proliferation during chronic infection by Rogel (1995)
10.1006/viro.1996.0302 / Virology / Evidence for direct association of Vpr and matrix protein p17 within the HIV-1 virion by Sato (1996)
10.1128/JVI.71.7.5579-5592.1997 / J. Virol. / Human immunodeficiency virus type 1 Vpr induces apoptosis following cell cycle arrest by Stewart (1997)
10.1074/jbc.270.43.25564 / J. Biol. Chem. / Interaction of virion protein Vpr of human immunodeficiency virus type 1 with cellular transcription factor Sp1 and trans-activation of viral long terminal repeat by Wang (1995)
10.1016/0378-1119(96)00312-5 / Gene / Characterization of a leucine-zipper-like domain in Vpr protein of human immunodeficiency virus type 1 by Wang (1996)
10.1089/aid.1987.3.33 / AIDS Res. Hum. Retroviruses / Human immunodeficiency virus: the eighth gene by Wong-Staal (1987)
10.1074/jbc.271.8.4201 / J. Biol. Chem. / Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA by Wu-Baer (1996)
10.1089/aid.1990.6.1265 / AIDS Res. Hum. Retroviruses / Human immunodeficiency virus vpr gene encodes a virion-associated protein by Yuan (1990)
10.1006/viro.1997.8459 / Virology / Cell cycle inhibitory effects of HIV and SIV Vpr and Vpx in the yeast Schizosaccharomyces pombe by Zhang (1997)
10.1016/S0021-9258(17)40719-8 / J. Biol. Chem. / Biochemical mechanism of HIV-I Vpr function. Specific interaction with a cellular protein by Zhao (1994)
10.1016/0378-1119(93)90032-X / Gene / A gene expression vector useful for protein purification and studies of protein–protein interaction by Zhao (1993)
10.1016/S0021-9258(18)31610-7 / J. Biol. Chem. / Biochemical mechanism of HIV-1 Vpr function. Oligomerization mediated by the N-terminal domain by Zhao (1994)

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 2:13 p.m.)
Deposited	4 years, 3 months ago (May 9, 2021, 11:32 a.m.)
Indexed	3 months, 2 weeks ago (May 18, 2025, 12:21 p.m.)
Issued	27 years, 3 months ago (June 1, 1998)
Published	27 years, 3 months ago (June 1, 1998)
Published Print	27 years, 3 months ago (June 1, 1998)

Funders 0

None

BibTeX

@article{Zhang_1998, title={Direct binding to nucleic acids by Vpr of human immunodeficiency virus type 1}, volume={212}, ISSN={0378-1119}, url={http://dx.doi.org/10.1016/s0378-1119(98)00178-4}, DOI={10.1016/s0378-1119(98)00178-4}, number={2}, journal={Gene}, publisher={Elsevier BV}, author={Zhang, Shangao and Pointer, Dawn and Singer, Greg and Feng, Yunfeng and Kathleen Park and Zhao, Ling-Jun}, year={1998}, month=jun, pages={157–166} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        5,
        18
      ]
    ],
    "date-time": "2025-05-18T16:21:58Z",
    "timestamp": 1747585318893
  },
  "reference-count": 41,
  "publisher": "Elsevier BV",
  "issue": "2",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1998,
            6,
            1
          ]
        ],
        "date-time": "1998-06-01T00:00:00Z",
        "timestamp": 896659200000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1998,
        6
      ]
    ]
  },
  "DOI": "10.1016/s0378-1119(98)00178-4",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        7,
        25
      ]
    ],
    "date-time": "2002-07-25T18:13:42Z",
    "timestamp": 1027620822000
  },
  "page": "157-166",
  "source": "Crossref",
  "is-referenced-by-count": 48,
  "title": "Direct binding to nucleic acids by Vpr of human immunodeficiency virus type 1",
  "prefix": "10.1016",
  "volume": "212",
  "author": [
    {
      "given": "Shangao",
      "family": "Zhang",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Dawn",
      "family": "Pointer",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Greg",
      "family": "Singer",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Yunfeng",
      "family": "Feng",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "family": "Kathleen Park",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Ling-Jun",
      "family": "Zhao",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/S0378-1119(98)00178-4_BIB1",
      "doi-asserted-by": "crossref",
      "first-page": "599",
      "DOI": "10.1006/jmbi.1996.0485",
      "article-title": "The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to TFIIB",
      "volume": "261",
      "author": "Agostini",
      "year": "1996",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/S0378-1119(98)00178-4_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "1117",
      "DOI": "10.1038/nm1097-1117",
      "article-title": "HIV-1 Vpr suppresses immune activation and apoptosis through regulation of nuclear factor kappa B",
      "volume": "3",
      "author": "Ayyavoo",
      "year": "1997",
      "journal-title": "Nat. Med."
    },
    {
      "key": "10.1016/S0378-1119(98)00178-4_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "623",
      "DOI": "10.1006/viro.1994.1225",
      "article-title": "Distinct effects in primary macrophages and lymphocytes of the human immunodeficiency virus type 1 accessory genes vpr, vpu, and nef: mutational analysis of a primary HIV-1 isolate",
      "volume": "200",
      "author": "Balliet",
      "year": "1994",
      "journal-title": "Virology"
    },
    {
      "key": "10.1016/S0378-1119(98)00178-4_BIB4",
      "doi-asserted-by": "crossref",
      "first-page": "4409",
      "DOI": "10.1128/JVI.67.7.4409-4414.1993",
      "article-title": "Antisense phosphorothioate oligodeoxynucleotides targeted to the vpr gene inhibit human immunodeficiency virus type 1 replication in primary human macrophages",
      "volume": "67",
      "author": "Balotta",
      "year": "1993",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/S0378-1119(98)00178-4_BIB5",
      "doi-asserted-by": "crossref",
      "first-page": "2324",
      "DOI": "10.1128/JVI.70.4.2324-2331.1996",
      "article-title": "Human immunodeficiency virus type 1 cell cycle control: Vpr is cytostatic and mediates G2 accumulation by a mechanism which differs from DNA damage checkpoint control",
      "volume": "70",
      "author": "Bartz",
      "year": "1996",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/S0378-1119(98)00178-4_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "666",
      "DOI": "10.1038/365666a0",
      "article-title": "A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells",
      "volume": "365",
      "author": "Bukrinsky",
      "year": "1993",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0378-1119(98)00178-4_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "3097",
      "DOI": "10.1128/JVI.64.6.3097-3099.1990",
      "article-title": "Human immunodeficiency virus vpr product is a virion-associated regulatory protein",
      "volume": "64",
      "author": "Cohen",
      "year": "1990",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/S0378-1119(98)00178-4_BIB8",
      "first-page": "11",
      "article-title": "Identification of HIV-1 vpr product and function",
      "volume": "3",
      "author": "Cohen",
      "year": "1990",
      "journal-title": "J. AIDS"
    },
    {
      "key": "10.1016/S0378-1119(98)00178-4_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "7517",
      "DOI": "10.1128/JVI.66.12.7517-7521.1992",
      "article-title": "An infectious molecular clone of an unusual macrophage-tropic and highly cytopathic strain of human immunodeficiency virus type 1",
      "volume": "66",
      "author": "Collman",
      "year": "1992",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/S0378-1119(98)00178-4_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "375",
      "DOI": "10.1128/MR.56.3.375-394.1992",
      "article-title": "Mechanism of action of regulatory proteins encoded by complex retroviruses",
      "volume": "56",
      "author": "Cullen",
      "year": "1992",
      "journal-title": "Microbiol. Rev."
    },
    {
      "key": "10.1016/S0378-1119(98)00178-4_BIB11",
      "doi-asserted-by": "crossref",
      "first-page": "30753",
      "DOI": "10.1074/jbc.272.49.30753",
      "article-title": "The zinc fingers of HIV nucleocapsid protein NCp7 direct interactions with the viral regulatory protein Vpr",
      "volume": "272",
      "author": "de Rocquigny",
      "year": "1997",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0378-1119(98)00178-4_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "7909",
      "DOI": "10.1128/JVI.69.12.7909-7916.1995",
      "article-title": "Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr",
      "volume": "69",
      "author": "Di Marzio",
      "year": "1995",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/S0378-1119(98)00178-4_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "6155",
      "DOI": "10.1002/j.1460-2075.1996.tb01003.x",
      "article-title": "Nuclear import and cell cycle arrest functions of the HIV-1 Vpr protein are encoded by two separate genes in HIV-2/SIV(SM)",
      "volume": "15",
      "author": "Fletcher",
      "year": "1996",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/S0378-1119(98)00178-4_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "2378",
      "DOI": "10.1128/JVI.69.4.2378-2383.1995",
      "article-title": "Progression to AIDS in the absence of a gene for vpr or vpx",
      "volume": "69",
      "author": "Gibbs",
      "year": "1995",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/S0378-1119(98)00178-4_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "453",
      "DOI": "10.1146/annurev.iy.08.040190.002321",
      "article-title": "Regulation of HIV-1 gene expression",
      "volume": "8",
      "author": "Greene",
      "year": "1990",
      "journal-title": "Annu. Rev. Immunol."
    },
    {
      "key": "10.1016/S0378-1119(98)00178-4_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "8080",
      "DOI": "10.1073/pnas.87.20.8080",
      "article-title": "The human immunodeficiency virus type 2 vpr gene is essential for productive infection of human macrophages",
      "volume": "87",
      "author": "Hattori",
      "year": "1990",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0378-1119(98)00178-4_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "6705",
      "DOI": "10.1128/JVI.69.11.6705-6711.1995",
      "article-title": "Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity",
      "volume": "69",
      "author": "He",
      "year": "1995",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/S0378-1119(98)00178-4_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "7311",
      "DOI": "10.1073/pnas.91.15.7311",
      "article-title": "The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells",
      "volume": "91",
      "author": "Heinzinger",
      "year": "1994",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0378-1119(98)00178-4_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "199",
      "DOI": "10.1126/science.3388031",
      "article-title": "Isolation and characterization of a novel protein (X-ORF product) from SIV and HIV-2",
      "volume": "241",
      "author": "Henderson",
      "year": "1988",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0378-1119(98)00178-4_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "326",
      "DOI": "10.1006/viro.1996.0201",
      "article-title": "Protein stability influences human immunodeficiency virus type 2 Vpr virion incorporation and cell cycle effect",
      "volume": "218",
      "author": "Kewalramani",
      "year": "1996",
      "journal-title": "Virology"
    },
    {
      "key": "10.1016/S0378-1119(98)00178-4_BIB21",
      "doi-asserted-by": "crossref",
      "first-page": "902",
      "DOI": "10.1128/JVI.67.2.902-912.1993",
      "article-title": "Importance of vpr for infection of rhesus monkeys with simian immunodeficiency virus",
      "volume": "67",
      "author": "Lang",
      "year": "1993",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/S0378-1119(98)00178-4_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "1926",
      "DOI": "10.1128/JVI.68.3.1926-1934.1994",
      "article-title": "Requirement of the Pr55gag precursor for incorporation of the Vpr product into human immunodeficiency virus type 1 viral particles",
      "volume": "68",
      "author": "Lavallee",
      "year": "1994",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/S0378-1119(98)00178-4_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "1243",
      "DOI": "10.1128/JVI.69.2.1243-1252.1995",
      "article-title": "Extracellular Vpr protein increases cellular permissiveness to human immunodeficiency virus replication and reactivates virus from latency",
      "volume": "69",
      "author": "Levy",
      "year": "1995",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/S0378-1119(98)00178-4_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "6542",
      "DOI": "10.1128/JVI.67.11.6542-6550.1993",
      "article-title": "Human immunodeficiency virus type 1 viral protein R localization in infected cells and virions",
      "volume": "67",
      "author": "Lu",
      "year": "1993",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/S0378-1119(98)00178-4_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "6339",
      "DOI": "10.1128/JVI.71.9.6339-6347.1997",
      "article-title": "Nuclear import, virion incorporation, and cell cycle arrest/differentiation are mediated by distinct functional domains of human immunodeficiency virus type 1 Vpr",
      "volume": "71",
      "author": "Mahalingam",
      "year": "1997",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/S0378-1119(98)00178-4_BIB26",
      "doi-asserted-by": "crossref",
      "first-page": "647",
      "DOI": "10.1006/viro.1995.0079",
      "article-title": "The carboxy-terminal domain is essential for stability and not for virion incorporation of HIV-1 Vpr into virus particles",
      "volume": "214",
      "author": "Mahalingam",
      "year": "1995",
      "journal-title": "Virology"
    },
    {
      "key": "10.1016/S0378-1119(98)00178-4_BIB27",
      "doi-asserted-by": "crossref",
      "first-page": "7229",
      "DOI": "10.1128/JVI.67.12.7229-7237.1993",
      "article-title": "Incorporation of Vpr into human immunodeficiency virus type 1 virions, requirement for the p6 region of gag and mutational analysis",
      "volume": "67",
      "author": "Paxton",
      "year": "1993",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/S0378-1119(98)00178-4_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "2516",
      "DOI": "10.1128/JVI.70.4.2516-2524.1996",
      "article-title": "Vpr-induced cell cycle arrest is conserved among primate lentiviruses",
      "volume": "70",
      "author": "Planelles",
      "year": "1996",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/S0378-1119(98)00178-4_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "6859",
      "DOI": "10.1128/JVI.69.11.6859-6864.1995",
      "article-title": "Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B",
      "volume": "69",
      "author": "Re",
      "year": "1995",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/S0378-1119(98)00178-4_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "882",
      "DOI": "10.1128/JVI.69.2.882-888.1995",
      "article-title": "The human immunodeficiency virus type 1 vpr gene prevents cell proliferation during chronic infection",
      "volume": "69",
      "author": "Rogel",
      "year": "1995",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/S0378-1119(98)00178-4_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "208",
      "DOI": "10.1006/viro.1996.0302",
      "article-title": "Evidence for direct association of Vpr and matrix protein p17 within the HIV-1 virion",
      "volume": "220",
      "author": "Sato",
      "year": "1996",
      "journal-title": "Virology"
    },
    {
      "key": "10.1016/S0378-1119(98)00178-4_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "5579",
      "DOI": "10.1128/JVI.71.7.5579-5592.1997",
      "article-title": "Human immunodeficiency virus type 1 Vpr induces apoptosis following cell cycle arrest",
      "volume": "71",
      "author": "Stewart",
      "year": "1997",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/S0378-1119(98)00178-4_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "25564",
      "DOI": "10.1074/jbc.270.43.25564",
      "article-title": "Interaction of virion protein Vpr of human immunodeficiency virus type 1 with cellular transcription factor Sp1 and trans-activation of viral long terminal repeat",
      "volume": "270",
      "author": "Wang",
      "year": "1995",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0378-1119(98)00178-4_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "7",
      "DOI": "10.1016/0378-1119(96)00312-5",
      "article-title": "Characterization of a leucine-zipper-like domain in Vpr protein of human immunodeficiency virus type 1",
      "volume": "178",
      "author": "Wang",
      "year": "1996",
      "journal-title": "Gene"
    },
    {
      "key": "10.1016/S0378-1119(98)00178-4_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "33",
      "DOI": "10.1089/aid.1987.3.33",
      "article-title": "Human immunodeficiency virus: the eighth gene",
      "volume": "3",
      "author": "Wong-Staal",
      "year": "1987",
      "journal-title": "AIDS Res. Hum. Retroviruses"
    },
    {
      "key": "10.1016/S0378-1119(98)00178-4_BIB36",
      "doi-asserted-by": "crossref",
      "first-page": "4201",
      "DOI": "10.1074/jbc.271.8.4201",
      "article-title": "Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA",
      "volume": "271",
      "author": "Wu-Baer",
      "year": "1996",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0378-1119(98)00178-4_BIB37",
      "doi-asserted-by": "crossref",
      "first-page": "1265",
      "DOI": "10.1089/aid.1990.6.1265",
      "article-title": "Human immunodeficiency virus vpr gene encodes a virion-associated protein",
      "volume": "6",
      "author": "Yuan",
      "year": "1990",
      "journal-title": "AIDS Res. Hum. Retroviruses"
    },
    {
      "key": "10.1016/S0378-1119(98)00178-4_BIB38",
      "doi-asserted-by": "crossref",
      "first-page": "103",
      "DOI": "10.1006/viro.1997.8459",
      "article-title": "Cell cycle inhibitory effects of HIV and SIV Vpr and Vpx in the yeast Schizosaccharomyces pombe",
      "volume": "230",
      "author": "Zhang",
      "year": "1997",
      "journal-title": "Virology"
    },
    {
      "key": "10.1016/S0378-1119(98)00178-4_BIB39",
      "doi-asserted-by": "crossref",
      "first-page": "15577",
      "DOI": "10.1016/S0021-9258(17)40719-8",
      "article-title": "Biochemical mechanism of HIV-I Vpr function. Specific interaction with a cellular protein",
      "volume": "269",
      "author": "Zhao",
      "year": "1994",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0378-1119(98)00178-4_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "345",
      "DOI": "10.1016/0378-1119(93)90032-X",
      "article-title": "A gene expression vector useful for protein purification and studies of protein\u2013protein interaction",
      "volume": "137",
      "author": "Zhao",
      "year": "1993",
      "journal-title": "Gene"
    },
    {
      "key": "10.1016/S0378-1119(98)00178-4_BIB41",
      "doi-asserted-by": "crossref",
      "first-page": "32131",
      "DOI": "10.1016/S0021-9258(18)31610-7",
      "article-title": "Biochemical mechanism of HIV-1 Vpr function. Oligomerization mediated by the N-terminal domain",
      "volume": "269",
      "author": "Zhao",
      "year": "1994",
      "journal-title": "J. Biol. Chem."
    }
  ],
  "container-title": "Gene",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0378111998001784?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0378111998001784?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        5,
        9
      ]
    ],
    "date-time": "2021-05-09T15:32:08Z",
    "timestamp": 1620574328000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0378111998001784"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1998,
        6
      ]
    ]
  },
  "references-count": 41,
  "journal-issue": {
    "issue": "2",
    "published-print": {
      "date-parts": [
        [
          1998,
          6
        ]
      ]
    }
  },
  "alternative-id": [
    "S0378111998001784"
  ],
  "URL": "http://dx.doi.org/10.1016/S0378-1119(98)00178-4",
  "relation": {},
  "ISSN": [
    "0378-1119"
  ],
  "subject": [],
  "container-title-short": "Gene",
  "published": {
    "date-parts": [
      [
        1998,
        6
      ]
    ]
  }
}