DOI: 10.1016/s0378-1119(00)00171-2. The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units

The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units

10.1016/s0378-1119(00)00171-2

Crossref journal-article

Elsevier BV

Gene (78)

Bibliography

Wu, K., Chung, L., Revill, W. P., Katz, L., & Reeves, C. D. (2000). The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units. Gene, 251(1), 81â90.

Authors 5

Kai Wu (first)
Loleta Chung (additional)
W.Peter Revill (additional)
Leonard Katz (additional)
Christopher D. Reeves (additional)

References 29 Referenced 225

10.1046/j.1432-1327.1998.2570395.x / Eur. J. Biochem. / A gene cluster encoding malonyl-CoA decarboxylase (MatA), malonyl-CoA synthetase (MatB) and a putative dicarboxylate carrier protein (MatC) in Rhizobium trifolii — cloning, sequencing and expression of the enzymes in Escherichia coli by An (1998)
10.1016/0378-1119(95)00800-4 / Gene / Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase by Aparicio (1996)
10.1271/bbb.59.582 / Biosci. Biotech. Biochem. / Nucleotide sequence analysis of the carbomycin biosynthetic genes including the 3-O-acyltransferase gene from Streptomyces thermotolerans by Arisawa (1995)
10.1016/S1074-5521(99)80074-X / Chem. Biol. / Impact of thioesterase activity on tylosin biosynthesis in Streptomyces fradiae by Butler (1999)
{'key': '10.1016/S0378-1119(00)00171-2_REF5', 'first-page': '29', 'article-title': 'The biosynthesis and enzymology of an immunosuppressant, immunomycin, produced by Streptomyces hygroscopicus var, ascomyceticus', 'volume': '32', 'author': 'Byrne', 'year': '1993', 'journal-title': 'Dev. Ind. Microbiol.'} / Dev. Ind. Microbiol. / The biosynthesis and enzymology of an immunosuppressant, immunomycin, produced by Streptomyces hygroscopicus var, ascomyceticus by Byrne (1993)
10.1046/j.1432-1327.1999.00244.x / Eur. J. Biochem. / Biosynthesis of ansatrienin (mycotrienin) and naphthomycin. Identification and analysis of two separate biosynthetic gene clusters in Streptomyces collinus Tu 1892 by Chen (1999)
10.1007/BF01570127 / J. Ind. Microbiol. / Genetic relationships among actinomycetes that produce the immunosuppressant macrolides FK506, FK520/FK523 and rapamycin by Garrity (1993)
10.1081/DMR-100101940 / Drug Metab. Rev. / FK506 and the role of the immunophilin FKBP-52 in nerve regeneration by Gold (1999)
10.1021/ja00452a079 / J. Am. Chem. Soc. / Biosynthetic origin of the C2 units of geldanamycin and distribution of label from d-[6-13C]glucose by Haber (1977)
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10.1128/jb.174.15.5141-5144.1992 / J. Bacteriol. / A macrolide 3-O-acyltransferase gene from the midecamycin-producing species Streptomyces mycarofaciens by Hara (1992)
10.1039/a806112b / Chem. Comm. / Investigation of glycerol incorporation into soraphen A by Hill (1998)
{'key': '10.1016/S0378-1119(00)00171-2_REF13', 'series-title': 'Genetic Manipulation of Streptomyces: A Laboratory Manual', 'author': 'Hopwood', 'year': '1985'} / Genetic Manipulation of Streptomyces: A Laboratory Manual by Hopwood (1985)
10.1128/jb.179.23.7515-7522.1997 / J. Bacteriol. / Identification and characterization of the niddamycin polyketide synthase genes from Streptomyces caelestis by Kakavas (1997)
10.1021/cr960025+ / Chem. Rev. / Manipulation of modular polyketide synthases by Katz (1997)
10.1128/JB.181.21.6806-6813.1999 / J. Bacteriol. / Role of crotonyl coenzyme A reductase in determining the ratio of polyketides monensin A and monensin B produced by Streptomyces cinnamonensis by Liu (1999)
10.1007/s002849900437 / Curr. Microbiol. / Accumulation of poly (3-hydroxybutyric acid) by some soil Streptomyces by Manna (1999)
10.1016/0378-1119(95)00799-7 / Gene / Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase by Molnár (1996)
10.1111/j.1432-1033.1997.00074.x / Eur. J. Biochem. / Structural organization of a multifunctional polyketide synthase involved in the biosynthesis of the macrolide immunosuppressant FK506 by Motamedi (1997)
10.1046/j.1432-1327.1998.2560528.x / Eur. J. Biochem. / The biosynthetic gene cluster for the macrolactone ring of the immunosuppressant FK506 by Motamedi (1998)
10.1128/jb.178.17.5243-5248.1996 / J. Bacteriol. / Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520 by Motamedi (1996)
10.7164/antibiotics.51.1019 / J. Antibiot. (Tokyo) / Structures and biosynthesis of aflastatins: novel inhibitors of aflatoxin production by Aspergillus parasiticus by Ono (1998)
10.1139/m93-055 / Can. J. Microbiol. / Accumulation of intracellular carbon reserves in relation to chloramphenicol biosynthesis by Streptomyces venezuelae by Ranade (1993)
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10.7164/antibiotics.50.701 / J. Antibiot. (Tokyo) / Biosynthesis of the shikimate-derived starter unit of the immunosuppressant ascomycin: stereochemistry of the 1,4-conjugate elimination by Reynolds (1997)
{'key': '10.1016/S0378-1119(00)00171-2_REF26', 'first-page': '99', 'article-title': 'Immunophilins, ligands, and the control of signal transduction', 'volume': '91', 'author': 'Schreiber', 'year': '1995', 'journal-title': 'Harvey Lect.'} / Harvey Lect. / Immunophilins, ligands, and the control of signal transduction by Schreiber (1995)
10.1073/pnas.92.17.7839 / Proc. Natl. Acad. Sci. USA / The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin by Schwecke (1995)
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10.1111/j.1432-1033.1995.954_3.x / Eur. J. Biochem. / Purification of crotonyl-CoA reductase from Streptomyces collinus and cloning, sequencing and expression of the corresponding gene in Escherichia coli by Wallace (1995)

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, noon)
Deposited	5 years, 7 months ago (Jan. 10, 2020, 5:40 p.m.)
Indexed	5 days, 1 hour ago (Aug. 29, 2025, 6:06 a.m.)
Issued	25 years, 3 months ago (June 1, 2000)
Published	25 years, 3 months ago (June 1, 2000)
Published Print	25 years, 3 months ago (June 1, 2000)

Funders 0

None

BibTeX

@article{Wu_2000, title={The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units}, volume={251}, ISSN={0378-1119}, url={http://dx.doi.org/10.1016/s0378-1119(00)00171-2}, DOI={10.1016/s0378-1119(00)00171-2}, number={1}, journal={Gene}, publisher={Elsevier BV}, author={Wu, Kai and Chung, Loleta and Revill, W.Peter and Katz, Leonard and Reeves, Christopher D.}, year={2000}, month=jun, pages={81–90} }

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    "published-print": {
      "date-parts": [
        [
          2000,
          6
        ]
      ]
    }
  },
  "alternative-id": [
    "S0378111900001712"
  ],
  "URL": "http://dx.doi.org/10.1016/S0378-1119(00)00171-2",
  "relation": {},
  "ISSN": [
    "0378-1119"
  ],
  "subject": [],
  "container-title-short": "Gene",
  "published": {
    "date-parts": [
      [
        2000,
        6
      ]
    ]
  }
}