DOI: 10.1016/s0304-4165(00)00185-9. Novel functions of complex carbohydrates elucidated by the mutant mice of glycosyltransferase genes

Novel functions of complex carbohydrates elucidated by the mutant mice of glycosyltransferase genes

10.1016/s0304-4165(00)00185-9

Crossref journal-article

Elsevier BV

Biochimica et Biophysica Acta (BBA) - General Subjects (78)

Bibliography

Furukawa, K., Takamiya, K., Okada, M., Inoue, M., Fukumoto, S., & Furukawa, K. (2001). Novel functions of complex carbohydrates elucidated by the mutant mice of glycosyltransferase genes. Biochimica et Biophysica Acta (BBA) - General Subjects, 1525(1â2), 1â12.

Authors 6

Koichi Furukawa (first)
Kogo Takamiya (additional)
Masahiko Okada (additional)
Masahiro Inoue (additional)
Satoshi Fukumoto (additional)
Keiko Furukawa (additional)

References 75 Referenced 55

10.1016/S0021-9258(17)30565-3 / J. Biol. Chem. / Bifunctional role of glycosphingolipids. Modulators for transmembrane signaling and mediators for cellular interactions by Hakomori (1990)
10.1093/glycob/3.2.97 / Glycobiology / Biological roles of oligosaccharides: all of the theories are correct by Varki (1993)
10.1007/BF00732424 / Glycoconj. J. / Will the transgenic mouse serve as a Rosetta Stone to glycoconjugate function? by Marth (1994)
10.1016/S0092-8674(00)80093-8 / Cell / Myelination in the absence of galactocerebroside and sulfatide: normal structure with abnormal function and regional instability by Coetzee (1996)
10.1073/pnas.93.23.13280 / Proc. Natl. Acad. Sci. USA / Functional breakdown of the lipid bilayer of the myelin membrane in central and peripheral nervous system by disrupted galactocerebroside synthesis by Bosio (1996)
10.1023/A:1006993501818 / Glycoconj. J. / UDP-galactose:ceramide galactosyltransferase is essential for spermatocyte passage into the first meiotic division in male mice by Fujimoto (1999)
K. Honke, Y. Hirahara, Y. Wada, N. Taniguchi, Physiological function of glycolipid sulfation, in: Abstracts of XXIst Japanese Carbohydrate Symposium, pp. 14–15 (in Japanese).
10.1073/pnas.93.20.10662 / Proc. Natl. Acad. Sci. USA / Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system by Takamiya (1996)
10.1073/pnas.95.21.12147 / Proc. Natl. Acad. Sci. USA / Complex gangliosides are essential in spermatogenesis of mice: possible roles in the transport of testosterone by Takamiya (1998)
10.1074/jbc.274.20.13744 / J. Biol. Chem. / Attenuation of interleukin 2 signal in the spleen cells of complex ganglioside-lacking mice by Zhao (1999)
{'key': '10.1016/S0304-4165(00)00185-9_BIB11', 'first-page': 'S57', 'article-title': 'Roles of glycosphingolipids in the nervous systems: Studies by the remodeling of carbohydrate moiety in cultured cells and in experimental animals', 'volume': '16', 'author': 'Furukawa', 'year': '1999', 'journal-title': 'Glycoconj. J.'} / Glycoconj. J. / Roles of glycosphingolipids in the nervous systems: Studies by the remodeling of carbohydrate moiety in cultured cells and in experimental animals by Furukawa (1999)
10.1073/pnas.96.13.7532 / Proc. Natl. Acad. Sci. USA / Mice lacking complex gangliosides develop Wallerian degeneration and myelination defects by Sheikh (1999)
10.1073/pnas.96.16.9142 / Proc. Natl. Acad. Sci. USA / A vital role for glycosphingolipid synthesis during development and differentiation by Yamashita (1999)
10.1073/pnas.91.2.728 / Proc. Natl. Acad. Sci. USA / Mice lacking N-acetylglucosaminyltransferase I activity die at mid-gestation, revealing an essential role for complex or hybrid N-linked carbohydrates by Ioffe (1994)
10.1002/j.1460-2075.1994.tb06480.x / EMBO J. / Complex asparagine-linked oligosaccharides are required for morphogenic events during post-implantation development by Metzler (1994)
10.1093/glycob/5.5.535 / Glycobiology / Complex asparagine-linked oligosaccharides in Mgat1-null embryos by Campbell (1995)
10.1093/glycob/7.7.913 / Glycobiology / Complex N-glycans in Mgat1 null preimplantation embryos arise from maternal Mgat1 RNA by Ioffe (1997)
10.1016/S0092-8674(00)80322-0 / Cell / Alpha-mannosidase-II deficiency results in dyserythropoiesis and unveils an alternate pathway in oligosaccharide biosynthesis by Chui (1997)
{'key': '10.1016/S0304-4165(00)00185-9_BIB19', 'first-page': '1122', 'article-title': 'Nephritis in α-mannosidase II deficient mice', 'volume': '9', 'author': 'Sellakumar', 'year': '1999', 'journal-title': 'Glycobiology'} / Glycobiology / Nephritis in α-mannosidase II deficient mice by Sellakumar (1999)
{'key': '10.1016/S0304-4165(00)00185-9_BIB20', 'first-page': 'S6', 'article-title': 'Characterization and in vivo role of α-mannosidase IIx, an enzyme encoded by a gene similar to the Golgi α-mannosidase II', 'volume': '16', 'author': 'Fukuda', 'year': '1999', 'journal-title': 'Glycoconj. J.'} / Glycoconj. J. / Characterization and in vivo role of α-mannosidase IIx, an enzyme encoded by a gene similar to the Golgi α-mannosidase II by Fukuda (1999)
M.N. Fukuda, personal communication.
10.1093/glycob/9.11.1263 / Glycobiology / A recessive deletion in the GlcNAc-1-phosphotransferase gene results in peri-implantation embryonic lethality by Marek (1999)
10.1093/emboj/16.8.1850 / EMBO J. / Growth retardation and early death of β-1,4-galactosyltransferase knockout mice with augmented proliferation and abnormal differentiation of epithelial cells by Asano (1997)
10.1006/dbio.1996.8444 / Dev. Biol. / Targeted mutation in β1,4-galactosyltransferase leads to pituitary insufficiency and neonatal lethality by Lu (1997)
10.1006/bbrc.1998.8537 / Biochem. Biophys. Res. Commun. / Presence of polysialic acid and HNK-1 carbohydrate on brain glycoproteins from β-1,4-galactosyltransferase-knockout mice by Kido (1998)
10.1073/pnas.95.2.472 / Proc. Natl. Acad. Sci. USA / Molecular cloning of a human cDNA encoding β-1,4-galactosyltransferase with 37% identity to mammalian UDP-Gal:GlcNAc β-1,4-galactosyltransferase by Sato (1998)
10.1242/dev.124.20.4121 / Development / Sperm from β1,4-galactosyltransferase-null mice are refractory to ZP3-induced acrosome reactions and penetrate the zona pellucida poorly by Lu (1997)
10.1074/jbc.270.37.21437 / J. Biol. Chem. / Oocyte Gal α1,3Gal epitopes implicated in sperm adhesion to the zona pellucida glycoprotein ZP3 are not required for fertilization in the mouse by Thall (1995)
10.1097/00007890-199601150-00004 / Transplantation / The α-1,3-galactosyltransferase knockout mouse. Implications for xenotransplantation by Tearle (1996)
10.1097/00007890-199709270-00016 / Transplantation / Combination of decay-accelerating factor expression and α1,3-galactosyltransferase knockout affords added protection from human complement-mediated injury by van Denderen (1997)
10.1093/glycob/7.1.45 / Glycobiology / Isolation, characterization and inactivation of the mouse Mgat3 gene: the bisecting N-acetylglucosamine in asparagine-linked oligosaccharides appears dispensable for viability and reproduction by Priatel (1997)
{'key': '10.1016/S0304-4165(00)00185-9_BIB32', 'first-page': '1121', 'article-title': 'DEN-induced hepatocarcinogenesis in Mgat3 gene knockout and transgenic mice: Further evidencs of an extra-hepatic role for the bisecting GlcNAc in tumor progression', 'volume': '9', 'author': 'Yang', 'year': '1999', 'journal-title': 'Glycobiology'} / Glycobiology / DEN-induced hepatocarcinogenesis in Mgat3 gene knockout and transgenic mice: Further evidencs of an extra-hepatic role for the bisecting GlcNAc in tumor progression by Yang (1999)
10.1038/73163 / Nature Med. / Suppression of tumor growth and metastasis in Mgat5-deficient mice by Granovsky (2000)
{'key': '10.1016/S0304-4165(00)00185-9_BIB34', 'first-page': 'S6', 'article-title': 'β1,6N-Acetylglucosaminyltransferase V regulates inflammation and breast cancer progression', 'volume': '16', 'author': 'Dennis', 'year': '1999', 'journal-title': 'Glycoconj. J.'} / Glycoconj. J. / β1,6N-Acetylglucosaminyltransferase V regulates inflammation and breast cancer progression by Dennis (1999)
10.1073/pnas.95.8.4504 / Proc. Natl. Acad. Sci. USA / Immune regulation by the ST6Gal sialyltransferase by Hennet (1998)
10.1126/science.274.5288.798 / Science / Hyperresponsive B cells in CD22-deficient mice by O’Keefe (1996)
10.1038/384634a0 / Nature / CD22 regulates thymus-independent responses and the lifespan of B cells by Otipoby (1996)
10.1016/S1074-7613(00)80270-8 / Immunity / CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction altered signaling in CD22-deficient mice by Sato (1996)
{'key': '10.1016/S0304-4165(00)00185-9_BIB39', 'first-page': '1099', 'article-title': 'The ST3Gal-IV sialylyltransferase functions in hematopoiesis and hemostasis in vivo', 'volume': '9', 'author': 'Ellies', 'year': '1999', 'journal-title': 'Glycobiology'} / Glycobiology / The ST3Gal-IV sialylyltransferase functions in hematopoiesis and hemostasis in vivo by Ellies (1999)
10.1016/S0092-8674(00)80137-3 / Cell / The α(1,3)fucosyltransferase Fuc-TVII controls leukocyte trafficking through an essential role in L-, E-, and P-selectin ligand biosynthesis by Maly (1996)
10.4049/jimmunol.161.11.6305 / J. Immunol. / α(1,3)-Fucosyltransferase VII-dependent synthesis of P- and E-selectin ligands on cultured T lymphoblasts by Knibbs (1998)
10.1073/pnas.96.8.4530 / Proc. Natl. Acad. Sci. USA / Reconstitution of functional L-selectin ligands on a cultured human endothelial cell line by cotransfection of α1→3 fucosyltransferase VII and newly cloned GlcNAcβ:6-sulfotransferase cDNA by Kimura (1999)
10.1016/S1074-7613(00)80217-4 / Immunity / Specialized contributions by α(1,3)-fucosyltransferase-IV and FucT-VII during leukocyte rolling in dermal microvessels by Weninger (2000)
M.C. Huang, O. Zollner, T. Moll, P. Maly, A.D. Thall, J.B. Lowe, D. Vestweber, P-selectin glycoprotein ligand-1 and E-selectin ligand-1 are differentially modified by fucosyl-transferases Fuc-TIV and Fuc-TVII in mouse neutrophils, J. Biol. Chem. (2000) in press. (10.1074/jbc.M005449200)
10.1016/S1074-7613(00)80653-6 / Immunity / Core 2 oligosaccharide biosynthesis distinguishes between selectin ligands essential for leukocyte homing and inflammation by Ellies (1998)
10.1016/S1074-7613(00)80180-6 / Immunity / The ST3Gal-I sialyltransferase controls CD8+ T lymphocyte homeostasis by modulating O-glycan biosynthesis by Priatel (2000)
10.1016/S0014-5793(99)01268-5 / FEBS Lett. / A novel human UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, GalNAc-T7, with specificity for partial GalNAc-glycosylated acceptor substrates by Bennett (1999)
10.1073/pnas.92.26.12070 / Proc. Natl. Acad. Sci. USA / T-cell-specific deletion of a polypeptide N-acetylgalactosaminyltransferase gene by site-directed recombination by Hennet (1995)
10.1074/jbc.272.21.13980 / J. Biol. Chem. / Molecular cloning and expression of Chinese hamster ovary cell heparan-sulfate 2-sulfotransferase by Kobayashi (1997)
10.1101/gad.12.12.1894 / Genes Dev. / Renal agenesis in mice homozygous for a gene trap mutation in the gene encoding heparan sulfate 2-sulfotransferase by Bullock (1998)
10.1242/dev.121.11.3687 / Development / The division abnormally delayed (dally) gene: a putative integral membrane proteoglycan required for cell division patterning during postembryonic development of the nervous system in Drosophila by Nakato (1995)
10.1038/22336 / Nature / The cell-surface proteoglycan Dally regulates Wingless signalling in Drosophila by Tsuda (1999)
10.1242/dev.124.16.3055 / Development / Defects in glucuronate biosynthesis disrupt Wingless signaling in Drosophila by Haerry (1997)
{'key': '10.1016/S0304-4165(00)00185-9_BIB54', 'first-page': 'S5', 'article-title': 'Hyaluronan biosynthesis and function in vertebrates', 'volume': '16', 'author': 'Spicer', 'year': '1999', 'journal-title': 'Glycoconj. J.'} / Glycoconj. J. / Hyaluronan biosynthesis and function in vertebrates by Spicer (1999)
10.1182/blood.V90.6.2217 / Blood / CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicity by Schmits (1997)
10.1038/23481 / Nature / Heparin is essential for the storage of specific granule proteases in mast cells by Humphries (1999)
10.1038/23488 / Nature / Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme by Forsberg (1999)
10.1074/jbc.274.33.22915 / J. Biol. Chem. / Human homolog of Caenorhabditis elegans sqv-3 gene is galactosyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans by Okajima (1999)
10.1074/jbc.274.41.28841 / J. Biol. Chem. / Molecular basis for the progeroid variant of Ehlers–Danlos syndrome. Identification and characterization of two mutations in galactosyltransferase I gene by Okajima (1999)
10.1074/jbc.274.37.26165 / J. Biol. Chem. / Cloning and expression of a proteoglycan UDP-galactose:β-xylose β1,4-galactosyltransferase I. A seventh member of the human β4-galactosyltransferase gene family by Almeida (1999)
10.1073/pnas.87.4.1342 / Proc. Natl. Acad. Sci. USA / A genetic defect in the biosynthesis of dermatan sulfate proteoglycan: galactosyltransferase I deficiency in fibroblasts from a patient with a progeroid syndrome by Quentin (1990)
10.1038/15537 / Nature Genet. / Perlecan is essential for cartilage and cephalic development by Arikawa-Hirasawa (1999)
10.1038/77108 / Nature Genet. / Syndecan-1 is required for wnt-1-induced mammary tumorigenesis in mice by Alexander (2000)
10.1074/jbc.275.8.5249 / J. Biol. Chem. / Syndecan-4 deficiency impairs focal adhesion formation only under restricted conditions by Ishiguro (2000)
10.1083/jcb.136.3.729 / J. Cell Biol. / Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility by Danielson (1997)
10.1038/1746 / Nature Genet. / Targeted disruption of the biglycan gene leads to an osteoporosis-like phenotype in mice by Xu (1998)
10.1074/jbc.273.41.26265 / J. Biol. Chem. / The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate by Lind (1998)
10.1038/514 / Nature Genet. / The putative tumour suppressor EXT1 alters the expression of cell-surface heparan sulfate by McCormick (1998)
10.1038/27932 / Nature / Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion by Bellaiche (1998)
10.1016/S1097-2765(00)80214-2 / Mol. Cell / Hedgehog movement is regulated through tout velu-dependent synthesis of a heparan sulfate proteoglycan by The (1999)
10.1006/dbio.2000.9798 / Dev. Biol. / Disruption of gastrulation and heparan sulfate biosynthesis in EXT1-deficient mice by Lin (2000)
10.1073/pnas.100471497 / Proc. Natl. Acad. Sci. USA / The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny by Shafi (2000)
{'key': '10.1016/S0304-4165(00)00185-9_BIB73', 'first-page': 'S12', 'article-title': 'Siat1, the multifaceted ST6Gal I gene: transcriptional complexity a reflection of functional diversity?', 'volume': '16', 'author': 'Lau', 'year': '1999', 'journal-title': 'Glycoconj. J.'} / Glycoconj. J. / Siat1, the multifaceted ST6Gal I gene: transcriptional complexity a reflection of functional diversity? by Lau (1999)
{'key': '10.1016/S0304-4165(00)00185-9_BIB74', 'first-page': '1111', 'article-title': 'The glycoworm C. elegans', 'volume': '9', 'author': 'Culotti', 'year': '1999', 'journal-title': 'Glycobiology'} / Glycobiology / The glycoworm C. elegans by Culotti (1999)
10.1111/j.1471-4159.1963.tb08933.x / J. Neurochem. / Chromatographic separation of human brain gangliosides by Svennerholm (1963)

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 3:45 p.m.)
Deposited	2 years, 4 months ago (April 12, 2023, 3:40 p.m.)
Indexed	1 month, 3 weeks ago (July 7, 2025, 1:44 a.m.)
Issued	24 years, 7 months ago (Feb. 1, 2001)
Published	24 years, 7 months ago (Feb. 1, 2001)
Published Print	24 years, 7 months ago (Feb. 1, 2001)

Funders 0

None

BibTeX

@article{Furukawa_2001, title={Novel functions of complex carbohydrates elucidated by the mutant mice of glycosyltransferase genes}, volume={1525}, ISSN={0304-4165}, url={http://dx.doi.org/10.1016/s0304-4165(00)00185-9}, DOI={10.1016/s0304-4165(00)00185-9}, number={1–2}, journal={Biochimica et Biophysica Acta (BBA) - General Subjects}, publisher={Elsevier BV}, author={Furukawa, Koichi and Takamiya, Kogo and Okada, Masahiko and Inoue, Masahiro and Fukumoto, Satoshi and Furukawa, Keiko}, year={2001}, month=feb, pages={1–12} }

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      "article-title": "Mice lacking N-acetylglucosaminyltransferase I activity die at mid-gestation, revealing an essential role for complex or hybrid N-linked carbohydrates",
      "volume": "91",
      "author": "Ioffe",
      "year": "1994",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "2056",
      "DOI": "10.1002/j.1460-2075.1994.tb06480.x",
      "article-title": "Complex asparagine-linked oligosaccharides are required for morphogenic events during post-implantation development",
      "volume": "13",
      "author": "Metzler",
      "year": "1994",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "535",
      "DOI": "10.1093/glycob/5.5.535",
      "article-title": "Complex asparagine-linked oligosaccharides in Mgat1-null embryos",
      "volume": "5",
      "author": "Campbell",
      "year": "1995",
      "journal-title": "Glycobiology"
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "913",
      "DOI": "10.1093/glycob/7.7.913",
      "article-title": "Complex N-glycans in Mgat1 null preimplantation embryos arise from maternal Mgat1 RNA",
      "volume": "7",
      "author": "Ioffe",
      "year": "1997",
      "journal-title": "Glycobiology"
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "157",
      "DOI": "10.1016/S0092-8674(00)80322-0",
      "article-title": "Alpha-mannosidase-II deficiency results in dyserythropoiesis and unveils an alternate pathway in oligosaccharide biosynthesis",
      "volume": "90",
      "author": "Chui",
      "year": "1997",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB19",
      "first-page": "1122",
      "article-title": "Nephritis in \u03b1-mannosidase II deficient mice",
      "volume": "9",
      "author": "Sellakumar",
      "year": "1999",
      "journal-title": "Glycobiology"
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB20",
      "first-page": "S6",
      "article-title": "Characterization and in vivo role of \u03b1-mannosidase IIx, an enzyme encoded by a gene similar to the Golgi \u03b1-mannosidase II",
      "volume": "16",
      "author": "Fukuda",
      "year": "1999",
      "journal-title": "Glycoconj. J."
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB21",
      "unstructured": "M.N. Fukuda, personal communication."
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "1263",
      "DOI": "10.1093/glycob/9.11.1263",
      "article-title": "A recessive deletion in the GlcNAc-1-phosphotransferase gene results in peri-implantation embryonic lethality",
      "volume": "9",
      "author": "Marek",
      "year": "1999",
      "journal-title": "Glycobiology"
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "1850",
      "DOI": "10.1093/emboj/16.8.1850",
      "article-title": "Growth retardation and early death of \u03b2-1,4-galactosyltransferase knockout mice with augmented proliferation and abnormal differentiation of epithelial cells",
      "volume": "16",
      "author": "Asano",
      "year": "1997",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "257",
      "DOI": "10.1006/dbio.1996.8444",
      "article-title": "Targeted mutation in \u03b21,4-galactosyltransferase leads to pituitary insufficiency and neonatal lethality",
      "volume": "181",
      "author": "Lu",
      "year": "1997",
      "journal-title": "Dev. Biol."
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "860",
      "DOI": "10.1006/bbrc.1998.8537",
      "article-title": "Presence of polysialic acid and HNK-1 carbohydrate on brain glycoproteins from \u03b2-1,4-galactosyltransferase-knockout mice",
      "volume": "245",
      "author": "Kido",
      "year": "1998",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB26",
      "doi-asserted-by": "crossref",
      "first-page": "472",
      "DOI": "10.1073/pnas.95.2.472",
      "article-title": "Molecular cloning of a human cDNA encoding \u03b2-1,4-galactosyltransferase with 37% identity to mammalian UDP-Gal:GlcNAc \u03b2-1,4-galactosyltransferase",
      "volume": "95",
      "author": "Sato",
      "year": "1998",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB27",
      "doi-asserted-by": "crossref",
      "first-page": "4121",
      "DOI": "10.1242/dev.124.20.4121",
      "article-title": "Sperm from \u03b21,4-galactosyltransferase-null mice are refractory to ZP3-induced acrosome reactions and penetrate the zona pellucida poorly",
      "volume": "124",
      "author": "Lu",
      "year": "1997",
      "journal-title": "Development"
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "21437",
      "DOI": "10.1074/jbc.270.37.21437",
      "article-title": "Oocyte Gal \u03b11,3Gal epitopes implicated in sperm adhesion to the zona pellucida glycoprotein ZP3 are not required for fertilization in the mouse",
      "volume": "270",
      "author": "Thall",
      "year": "1995",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "13",
      "DOI": "10.1097/00007890-199601150-00004",
      "article-title": "The \u03b1-1,3-galactosyltransferase knockout mouse. Implications for xenotransplantation",
      "volume": "61",
      "author": "Tearle",
      "year": "1996",
      "journal-title": "Transplantation"
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "882",
      "DOI": "10.1097/00007890-199709270-00016",
      "article-title": "Combination of decay-accelerating factor expression and \u03b11,3-galactosyltransferase knockout affords added protection from human complement-mediated injury",
      "volume": "27",
      "author": "van Denderen",
      "year": "1997",
      "journal-title": "Transplantation"
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "45",
      "DOI": "10.1093/glycob/7.1.45",
      "article-title": "Isolation, characterization and inactivation of the mouse Mgat3 gene: the bisecting N-acetylglucosamine in asparagine-linked oligosaccharides appears dispensable for viability and reproduction",
      "volume": "7",
      "author": "Priatel",
      "year": "1997",
      "journal-title": "Glycobiology"
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB32",
      "first-page": "1121",
      "article-title": "DEN-induced hepatocarcinogenesis in Mgat3 gene knockout and transgenic mice: Further evidencs of an extra-hepatic role for the bisecting GlcNAc in tumor progression",
      "volume": "9",
      "author": "Yang",
      "year": "1999",
      "journal-title": "Glycobiology"
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "306",
      "DOI": "10.1038/73163",
      "article-title": "Suppression of tumor growth and metastasis in Mgat5-deficient mice",
      "volume": "6",
      "author": "Granovsky",
      "year": "2000",
      "journal-title": "Nature Med."
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB34",
      "first-page": "S6",
      "article-title": "\u03b21,6N-Acetylglucosaminyltransferase V regulates inflammation and breast cancer progression",
      "volume": "16",
      "author": "Dennis",
      "year": "1999",
      "journal-title": "Glycoconj. J."
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "4504",
      "DOI": "10.1073/pnas.95.8.4504",
      "article-title": "Immune regulation by the ST6Gal sialyltransferase",
      "volume": "95",
      "author": "Hennet",
      "year": "1998",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB36",
      "doi-asserted-by": "crossref",
      "first-page": "798",
      "DOI": "10.1126/science.274.5288.798",
      "article-title": "Hyperresponsive B cells in CD22-deficient mice",
      "volume": "274",
      "author": "O\u2019Keefe",
      "year": "1996",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB37",
      "doi-asserted-by": "crossref",
      "first-page": "634",
      "DOI": "10.1038/384634a0",
      "article-title": "CD22 regulates thymus-independent responses and the lifespan of B cells",
      "volume": "384",
      "author": "Otipoby",
      "year": "1996",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB38",
      "doi-asserted-by": "crossref",
      "first-page": "551",
      "DOI": "10.1016/S1074-7613(00)80270-8",
      "article-title": "CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction altered signaling in CD22-deficient mice",
      "volume": "5",
      "author": "Sato",
      "year": "1996",
      "journal-title": "Immunity"
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB39",
      "first-page": "1099",
      "article-title": "The ST3Gal-IV sialylyltransferase functions in hematopoiesis and hemostasis in vivo",
      "volume": "9",
      "author": "Ellies",
      "year": "1999",
      "journal-title": "Glycobiology"
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "643",
      "DOI": "10.1016/S0092-8674(00)80137-3",
      "article-title": "The \u03b1(1,3)fucosyltransferase Fuc-TVII controls leukocyte trafficking through an essential role in L-, E-, and P-selectin ligand biosynthesis",
      "volume": "86",
      "author": "Maly",
      "year": "1996",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB41",
      "doi-asserted-by": "crossref",
      "first-page": "6305",
      "DOI": "10.4049/jimmunol.161.11.6305",
      "article-title": "\u03b1(1,3)-Fucosyltransferase VII-dependent synthesis of P- and E-selectin ligands on cultured T lymphoblasts",
      "volume": "161",
      "author": "Knibbs",
      "year": "1998",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB42",
      "doi-asserted-by": "crossref",
      "first-page": "4530",
      "DOI": "10.1073/pnas.96.8.4530",
      "article-title": "Reconstitution of functional L-selectin ligands on a cultured human endothelial cell line by cotransfection of \u03b11\u21923 fucosyltransferase VII and newly cloned GlcNAc\u03b2:6-sulfotransferase cDNA",
      "volume": "96",
      "author": "Kimura",
      "year": "1999",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB43",
      "doi-asserted-by": "crossref",
      "first-page": "665",
      "DOI": "10.1016/S1074-7613(00)80217-4",
      "article-title": "Specialized contributions by \u03b1(1,3)-fucosyltransferase-IV and FucT-VII during leukocyte rolling in dermal microvessels",
      "volume": "12",
      "author": "Weninger",
      "year": "2000",
      "journal-title": "Immunity"
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB44",
      "doi-asserted-by": "crossref",
      "unstructured": "M.C. Huang, O. Zollner, T. Moll, P. Maly, A.D. Thall, J.B. Lowe, D. Vestweber, P-selectin glycoprotein ligand-1 and E-selectin ligand-1 are differentially modified by fucosyl-transferases Fuc-TIV and Fuc-TVII in mouse neutrophils, J. Biol. Chem. (2000) in press.",
      "DOI": "10.1074/jbc.M005449200"
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB45",
      "doi-asserted-by": "crossref",
      "first-page": "881",
      "DOI": "10.1016/S1074-7613(00)80653-6",
      "article-title": "Core 2 oligosaccharide biosynthesis distinguishes between selectin ligands essential for leukocyte homing and inflammation",
      "volume": "9",
      "author": "Ellies",
      "year": "1998",
      "journal-title": "Immunity"
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB46",
      "doi-asserted-by": "crossref",
      "first-page": "273",
      "DOI": "10.1016/S1074-7613(00)80180-6",
      "article-title": "The ST3Gal-I sialyltransferase controls CD8+ T lymphocyte homeostasis by modulating O-glycan biosynthesis",
      "volume": "12",
      "author": "Priatel",
      "year": "2000",
      "journal-title": "Immunity"
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB47",
      "doi-asserted-by": "crossref",
      "first-page": "226",
      "DOI": "10.1016/S0014-5793(99)01268-5",
      "article-title": "A novel human UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, GalNAc-T7, with specificity for partial GalNAc-glycosylated acceptor substrates",
      "volume": "460",
      "author": "Bennett",
      "year": "1999",
      "journal-title": "FEBS Lett."
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB48",
      "doi-asserted-by": "crossref",
      "first-page": "12070",
      "DOI": "10.1073/pnas.92.26.12070",
      "article-title": "T-cell-specific deletion of a polypeptide N-acetylgalactosaminyltransferase gene by site-directed recombination",
      "volume": "92",
      "author": "Hennet",
      "year": "1995",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB49",
      "doi-asserted-by": "crossref",
      "first-page": "13980",
      "DOI": "10.1074/jbc.272.21.13980",
      "article-title": "Molecular cloning and expression of Chinese hamster ovary cell heparan-sulfate 2-sulfotransferase",
      "volume": "272",
      "author": "Kobayashi",
      "year": "1997",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB50",
      "doi-asserted-by": "crossref",
      "first-page": "1894",
      "DOI": "10.1101/gad.12.12.1894",
      "article-title": "Renal agenesis in mice homozygous for a gene trap mutation in the gene encoding heparan sulfate 2-sulfotransferase",
      "volume": "12",
      "author": "Bullock",
      "year": "1998",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB51",
      "doi-asserted-by": "crossref",
      "first-page": "3687",
      "DOI": "10.1242/dev.121.11.3687",
      "article-title": "The division abnormally delayed (dally) gene: a putative integral membrane proteoglycan required for cell division patterning during postembryonic development of the nervous system in Drosophila",
      "volume": "121",
      "author": "Nakato",
      "year": "1995",
      "journal-title": "Development"
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB52",
      "doi-asserted-by": "crossref",
      "first-page": "276",
      "DOI": "10.1038/22336",
      "article-title": "The cell-surface proteoglycan Dally regulates Wingless signalling in Drosophila",
      "volume": "400",
      "author": "Tsuda",
      "year": "1999",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB53",
      "doi-asserted-by": "crossref",
      "first-page": "3055",
      "DOI": "10.1242/dev.124.16.3055",
      "article-title": "Defects in glucuronate biosynthesis disrupt Wingless signaling in Drosophila",
      "volume": "124",
      "author": "Haerry",
      "year": "1997",
      "journal-title": "Development"
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB54",
      "first-page": "S5",
      "article-title": "Hyaluronan biosynthesis and function in vertebrates",
      "volume": "16",
      "author": "Spicer",
      "year": "1999",
      "journal-title": "Glycoconj. J."
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB55",
      "doi-asserted-by": "crossref",
      "first-page": "2217",
      "DOI": "10.1182/blood.V90.6.2217",
      "article-title": "CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicity",
      "volume": "90",
      "author": "Schmits",
      "year": "1997",
      "journal-title": "Blood"
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB56",
      "doi-asserted-by": "crossref",
      "first-page": "769",
      "DOI": "10.1038/23481",
      "article-title": "Heparin is essential for the storage of specific granule proteases in mast cells",
      "volume": "400",
      "author": "Humphries",
      "year": "1999",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB57",
      "doi-asserted-by": "crossref",
      "first-page": "773",
      "DOI": "10.1038/23488",
      "article-title": "Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme",
      "volume": "400",
      "author": "Forsberg",
      "year": "1999",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB58",
      "doi-asserted-by": "crossref",
      "first-page": "22915",
      "DOI": "10.1074/jbc.274.33.22915",
      "article-title": "Human homolog of Caenorhabditis elegans sqv-3 gene is galactosyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans",
      "volume": "274",
      "author": "Okajima",
      "year": "1999",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB59",
      "doi-asserted-by": "crossref",
      "first-page": "28841",
      "DOI": "10.1074/jbc.274.41.28841",
      "article-title": "Molecular basis for the progeroid variant of Ehlers\u2013Danlos syndrome. Identification and characterization of two mutations in galactosyltransferase I gene",
      "volume": "274",
      "author": "Okajima",
      "year": "1999",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB60",
      "doi-asserted-by": "crossref",
      "first-page": "26165",
      "DOI": "10.1074/jbc.274.37.26165",
      "article-title": "Cloning and expression of a proteoglycan UDP-galactose:\u03b2-xylose \u03b21,4-galactosyltransferase I. A seventh member of the human \u03b24-galactosyltransferase gene family",
      "volume": "274",
      "author": "Almeida",
      "year": "1999",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB61",
      "doi-asserted-by": "crossref",
      "first-page": "1342",
      "DOI": "10.1073/pnas.87.4.1342",
      "article-title": "A genetic defect in the biosynthesis of dermatan sulfate proteoglycan: galactosyltransferase I deficiency in fibroblasts from a patient with a progeroid syndrome",
      "volume": "87",
      "author": "Quentin",
      "year": "1990",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB62",
      "doi-asserted-by": "crossref",
      "first-page": "354",
      "DOI": "10.1038/15537",
      "article-title": "Perlecan is essential for cartilage and cephalic development",
      "volume": "23",
      "author": "Arikawa-Hirasawa",
      "year": "1999",
      "journal-title": "Nature Genet."
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB63",
      "doi-asserted-by": "crossref",
      "first-page": "329",
      "DOI": "10.1038/77108",
      "article-title": "Syndecan-1 is required for wnt-1-induced mammary tumorigenesis in mice",
      "volume": "25",
      "author": "Alexander",
      "year": "2000",
      "journal-title": "Nature Genet."
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB64",
      "doi-asserted-by": "crossref",
      "first-page": "5249",
      "DOI": "10.1074/jbc.275.8.5249",
      "article-title": "Syndecan-4 deficiency impairs focal adhesion formation only under restricted conditions",
      "volume": "275",
      "author": "Ishiguro",
      "year": "2000",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0304-4165(00)00185-9_BIB65",
      "doi-asserted-by": "crossref",
      "first-page": "729",
      "DOI": "10.1083/jcb.136.3.729",
      "article-title": "Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility",
      "volume": "136",
      "author": "Danielson",
      "year": "1997",
      "journal-title": "J. Cell Biol."
    },
    {
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      "volume": "273",
      "author": "Lind",
      "year": "1998",
      "journal-title": "J. Biol. Chem."
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      "author": "McCormick",
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      "volume": "394",
      "author": "Bellaiche",
      "year": "1998",
      "journal-title": "Nature"
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      "volume": "4",
      "author": "The",
      "year": "1999",
      "journal-title": "Mol. Cell"
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      "author": "Lin",
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      "volume": "97",
      "author": "Shafi",
      "year": "2000",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
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      "volume": "16",
      "author": "Lau",
      "year": "1999",
      "journal-title": "Glycoconj. J."
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      "article-title": "The glycoworm C. elegans",
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      "article-title": "Chromatographic separation of human brain gangliosides",
      "volume": "10",
      "author": "Svennerholm",
      "year": "1963",
      "journal-title": "J. Neurochem."
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