DOI: 10.1016/s0304-3959(00)00245-1. Lumbar transplant of neurons genetically modified to secrete brain-derived neurotrophic factor attenuates allodynia and hyperalgesia after sciatic nerve constriction

Lumbar transplant of neurons genetically modified to secrete brain-derived neurotrophic factor attenuates allodynia and hyperalgesia after sciatic nerve constriction

10.1016/s0304-3959(00)00245-1

Crossref journal-article

Ovid Technologies (Wolters Kluwer Health)

Pain (276)

Bibliography

Cejas, P. J., Martinez, M., Karmally, S., McKillop, M., McKillop, J., Plunkett, J. A., Oudega, M., & Eaton, M. J. (2000). Lumbar transplant of neurons genetically modified to secrete brain-derived neurotrophic factor attenuates allodynia and hyperalgesia after sciatic nerve constriction. Pain, 86(1), 195â210.

Authors 8

P. J. Cejas (first)
M. Martinez (additional)
S. Karmally (additional)
M. McKillop (additional)
J. McKillop (additional)
J. A. Plunkett (additional)
M. Oudega (additional)
M. J. Eaton (additional)

References 111 Referenced 98

10.1038/374450a0 / Nature / A BDNF autocrine loop in adult sensory neurons prevents cell death. by Acheson (1995)
10.1038/2021222a0 / Nature / Spinal reflexes and monoamine liberation. by Anden (1964)
10.1111/j.1460-9568.1996.tb01314.x / Eur J Neurosci / Effects of BDNF and NT45 on striatonigral neuropeptides or nigral GABA neurons in vivo. by Arenas (1996)
10.1016/0304-3959(88)90209-6 / Pain / A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. by Bennett (1988)
10.1006/exnr.1997.6730 / Exp Neurol / Transplantation of cryopreserved human embryonal carcinoma-derived (NT2N cells) promotes functional recovery in ischemic rats. by Borlongan (1998)
10.1523/JNEUROSCI.18-19-07953.1998 / J Neurosci / Brain-derived neurotrophic factor and basic fibroblast growth factor downregulate NMDA receptor function in cerebellar granule cells. by Brandoli (1998)
10.1016/0006-8993(89)90144-3 / Brain Res / Survival and growth of hippocampal neurons in defined medium at low density: advantages of a sandwich culture technique or low oxygen. by Brewer (1989)
10.1515/BC.1999.078 / Biol Chem / Adeno-associated viral vectors for gene transfer and gene therapy. by Bueler (1999)
{'key': 'R10-24-20210112', 'first-page': '1945', 'article-title': 'A BDNF-synthesizing cell line ameliorates chronic neuropathic pain (abstract).', 'volume': '25', 'author': 'Cejas', 'year': '1999', 'journal-title': 'Soc Neurosci Abstr'} / Soc Neurosci Abstr / A BDNF-synthesizing cell line ameliorates chronic neuropathic pain (abstract). by Cejas (1999)
10.1016/0165-0270(94)90144-9 / J Neurosci Methods / Quantitative assessment of tactile allodynia in the rat paw. by Chaplan (1994)
10.1016/0143-4179(92)90115-D / Neuropeptides / The effects of sandostatin and somatostatin on nociceptive transmission in the dorsal horn of the rat spinal cord. by Chapman (1992)
10.1016/S0006-8993(97)00597-0 / Brain Res / Increased brain-derived neurotrophic factor immunoreactivity in rat dorsal root ganglia and spinal cord following peripheral inflammation. by Cho (1997)
10.1016/S0006-8993(97)00048-6 / Brain Res / Expression of mRNA for brain-derived neurotrophic factor in the dorsal root ganglion following peripheral inflammation. by Cho (1997)
10.1006/exnr.1998.6936 / Exp Neurol / Changes in brain-derived neurotrophic factor immunoreactivity in rat dorsal root ganglia, spinal cord, and gracile nuclei following cut or crush injuries. by Cho (1998)
10.1523/JNEUROSCI.17-07-02295.1997 / J Neurosci / Distribution of brain-derived neurotrophic factor (BDNF) protein and mRNA in the normal adult rat CNS: evidence for anterograde axonal transport. by Conner (1997)
10.1515/REVNEURO.1998.9.2.91 / Rev Neurosci / Anterograde transport of neurotropin proteins in the CNS - a reassessment of the neurotropic hypothesis. by Conner (1998)
10.1111/j.1460-9568.1994.tb00325.x / Eur J Neurosci / Regulation of neuropeptides in adult rat forebrain by the neurotrophins BDNF and NGF. by Croll (1994)
10.1016/0301-0082(95)00011-J / Prog Neurobiol / Update on cellular transplantation into the CNS as a novel therapy for chronic pain. by Czech (1995)
10.1016/0006-8993(81)90018-4 / Brain Res / 5-Hydroxytryptamine reduces substance P responses on dorsal interneurones: a possible interaction of neurotransmitters. by Davies (1981)
10.1016/S0306-3623(96)00359-X / Gen Pharm / The pharmacology of excitatory and inhibitory amino acid-mediated events in the transmission and modulation of pain in the spinal cord. by Dickenson (1997)
10.1016/0306-4522(91)90092-3 / Neuroscience / Microinjection of neuropeptide Y into the superficial dorsal horn reduces stimulus-evoked release of immunoreactive substance P in the anesthetized cat. by Duggan (1991)
10.1006/exnr.1996.0121 / Exp Neurol / Autocrine BDNF secretion enhances the survival and serotonergic differentiation of raphe neuronal precursor cells grafted into the adult rat CNS. by Eaton (1996)
10.1016/S0021-9258(17)46207-7 / J Biol Chem / Immunohistochemical characterization of brain synaptic membrane glutamate-binding proteins. by Eaton (1990)
10.1006/dbio.1995.1205 / Dev Biol / Developmental regulation of early serotonergic neuronal differentiation: the role of brain-derived neurotrophic factor and membrane depolarization. by Eaton (1995)
{'key': 'R26-24-20210112', 'first-page': '1455', 'article-title': 'Autocrine BDNF secretion enhances the survival and serotonergic differentiation of grafted raphe neuronal precursor cells and lumbar transplants alleviate chronic neuropathic pain (abstract).', 'volume': '23', 'author': 'Eaton', 'year': '1996', 'journal-title': 'Soc Neurosci Abstr'} / Soc Neurosci Abstr / Autocrine BDNF secretion enhances the survival and serotonergic differentiation of grafted raphe neuronal precursor cells and lumbar transplants alleviate chronic neuropathic pain (abstract). by Eaton (1996)
10.1016/S0304-3959(97)00015-8 / Pain / Lumbar transplants of immortalized serotonergic neurons alleviates chronic neuropathic pain. by Eaton (1997)
10.1016/S0891-0618(98)00062-3 / J Chem Neuroanat / Changes in GAD and GABA immunoreactivity in the spinal dorsal horn after peripheral nerve injury and promotion of recovery by lumbar transplant of immortalized serotonergic neurons. by Eaton (1998)
10.1016/S0006-8993(99)01564-4 / Brain Res / A single dose of intrathecal GABA permanently reverses neuropathic pain after nerve injury. by Eaton (1999)
10.1177/096368979900800102 / Cell Transplant / Transplants of neuronal cells bio-engineered to synthesize GABA alleviate chronic neuropathic pain. by Eaton (1999)
10.1016/0896-6273(90)90090-3 / Neuron / Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor family. by Enfors (1990)
10.1016/0169-328X(93)90005-A / Brain Res Mol Brain Res / Expression of mRNAs for neurotrophin receptors in the dorsal root ganglion and spinal cord during development and following peripheral or central axotomy. by Enfors (1993)
10.1523/JNEUROSCI.18-08-02808.1998 / J Neurosci / Functional evidence that BDNF is an anterograde neuronal trophic factor in the CNS. by Fawcett (1998)
10.1006/exnr.1997.6440 / Exp Neurol / Effects of BDNF infusion on the regulation of TrkB protein and message in adult rat brain. by Frank (1997)
10.1073/pnas.89.23.11282 / Proc Natl Acad Sci USA / Increased levels of trkB mRNA and trkB protein-like immunoreactivity in the injured rat and cat spinal cord. by Frisen (1992)
10.1016/S0304-3959(98)00111-0 / Pain / Change in mRNAs for neuropeptides and the GABA(A) receptor in dorsal root ganglion neurons in a rat experimental neuropathic pain model. by Fukuoka (1998)
10.1083/jcb.123.2.455 / J Cell Biol / Differential expression of the mRNA for neurotrophins and their receptors after axotomy of the sciatic nerve. by Funakoshi (1993)
10.1177/096368979600500211 / Cell Transplant / Cell-mediated delivery of brain-derived neurotrophic factor enhances dopamine levels in an MPP rat model of substantia nigra degeneration. by Galpern (1996)
10.1002/(SICI)1097-0029(19990515/01)45:4/5<262::AID-JEMT10>3.0.CO;2-K / Microsci Res Tech / Are there differences between secretion characteristics of NGF and BDNF? Implications for the modulatory role of neurotrophins in activity-dependent neuronal plasticity. by Griesbeck (1999)
10.1016/0304-3959(92)90070-R / Pain / Chronic pain related syndrome in rats after ischemic spinal cord lesion: a possible animal model for pain in patients with spinal cord injury. by Hao (1992)
10.1016/0304-3959(88)90026-7 / Pain / A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. by Hargreaves (1988)
10.1016/0306-4522(96)00196-0 / Neuroscience / Upregulation of spinal glutamate receptors in chronic pain. by Harris (1996)
10.1016/0304-3940(95)11345-2 / Neurosci Lett / Inhibition of spinal nociceptive neurons by microinjections of somatostatin into the nucleus raphe magnus and the midbrain periaqueductal gray of the anesthetized cat. by Helmchen (1995)
{'key': 'R45-24-20210112', 'first-page': '319', 'article-title': 'A reversible immortalization procedure to obtain neural cell lines (abstract).', 'volume': '23', 'author': 'Herman', 'year': '1997', 'journal-title': 'Soc Neurosci Abstr'} / Soc Neurosci Abstr / A reversible immortalization procedure to obtain neural cell lines (abstract). by Herman (1997)
{'key': 'R46-24-20210112', 'first-page': '1539', 'article-title': 'Characterization of mesencephalic cell lines created by a reversible immortalization procedure (abstract).', 'volume': '25', 'author': 'Herman', 'year': '1999', 'journal-title': 'Soc Neurosci Abstr'} / Soc Neurosci Abstr / Characterization of mesencephalic cell lines created by a reversible immortalization procedure (abstract). by Herman (1999)
10.1016/0306-4522(88)90076-0 / Neuroscience / Locus coeruleus neurons in the rat containing neuropeptide Y, tyrosine hydroxylase, or galanin and their efferent projections to the spinal cord, cerebral cortex, and hypothalamus. by Holets (1988)
{'key': 'R48-24-20210112', 'first-page': '243', 'article-title': 'The antinociceptive effects of spinally administered neuropeptide Y in the rat: systemic studies on structure-activity relationship.', 'volume': '258', 'author': 'Hua', 'year': '1991', 'journal-title': 'J Pharm Exp Ther'} / J Pharm Exp Ther / The antinociceptive effects of spinally administered neuropeptide Y in the rat: systemic studies on structure-activity relationship. by Hua (1991)
10.1016/S0304-3959(96)03249-6 / Pain / The effect of spinal GABA receptor agonists on tactile allodynia in a surgically-induced neuropathic pain model in the rat. by Hwang (1997)
10.1523/JNEUROSCI.14-01-00335.1994 / J Neurosci / Overlapping and distinct actions of the neurotrophins BDNF, NT-3, and NT-45 on cultured dopaminergic and GABAergic neurons of the ventral mesencephalon. by Hyman (1994)
10.1006/excr.1998.4272 / Exp Cell Res / SV40-mediated immortalization. by Jha (1998)
10.1007/BF00618257 / J Neurol / Staining with monoclonal antibodies to neurofilaments distinguishes between subpopulations of neurofibrillary tangles, between groups of axons and between groups of dendrites. by Kahn (1987)
10.1016/S0304-3959(96)03222-8 / Pain / Involvement of increased excitatory amino acids and intracellular Ca2 concentration in the spinal dorsal horn in an animal model of neuropathic pain. by Kawamata (1996)
10.1016/0006-8993(86)91222-9 / Brain Res / Cryopreservation of primary neurons for tissue culture. by Kawamoto (1986)
10.1523/JNEUROSCI.19-12-05138.1999 / J Neurosci / Brain-derived neurotropic factor modulates nociceptive sensory inputs and NMDA-evoked responses in the rat spinal cord. by Kerr (1999)
10.1016/0304-3959(92)90041-9 / Pain / An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. by Kim (1992)
10.1097/00001756-199609020-00033 / NeuroReport / Treatment with genetically engineered fibroblasts producing NGF or BDNF can accelerate recovery from traumatic spinal cord injury in the adult rat. by Kim (1996)
10.1016/0014-4886(88)90033-7 / Exp Neurol / Diminished dorsal root GABA sensitivity following chronic peripheral nerve injury. by Kingery (1988)
10.1111/j.1365-2125.1983.tb02203.x / Br J Clin Pharm / The analgesic effect of the GABA-agonist THIP in patients with chronic pain of malignant origin. by Kjaer (1983)
{'key': 'R60-24-20210112', 'first-page': '738', 'article-title': 'Role of mouse neurotrophins in mouse neuronal development.', 'volume': '8', 'author': 'Klein', 'year': '1994', 'journal-title': 'Fed Am Soc Exp Biol J'} / Fed Am Soc Exp Biol J / Role of mouse neurotrophins in mouse neuronal development. by Klein (1994)
10.1016/0092-8674(91)90628-C / Cell / The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3. by Klein (1991)
10.1016/0896-6273(93)90326-M / Neuron / Evidence that brain-derived neurotrophic factor is a trophic factor for motor neurons in vivo. by Koliatsos (1993)
10.1046/j.1471-4159.1996.66041362.x / J Neurochem / Characterization of the responses of Purkinje cells to neurotrophin treatment. by Larkfors (1996)
10.1016/S0304-3940(98)00958-6 / Neurosci Lett / Upregulation of brain-derived neurotrophic factor and neuropeptide Y in the dorsal ascending sensory pathway following sciatic nerve injury in rat. by Li (1999)
10.1016/0306-4522(84)90136-2 / Neuroscience / Spinal cord contains neurotrophic activity for spinal sensory neurons. Late developmental appearance of a survival factor distinct from nerve growth factor. by Lindsay (1984)
10.1016/0012-1606(85)90402-6 / Dev Biol / Placode and neural crest-derived sensory neurons responsive at early developmental stages to brain-derived neurotrophic factor. by Lindsay (1985)
10.1523/JNEUROSCI.19-11-04370.1999 / J Neurosci / Transplants of fibroblasts genetically modified to express BDNF promote regeneration of adult rat rubrospinal axons and recovery of forelimb function. by Liu (1999)
10.1016/S0304-3940(99)00040-3 / Neurosci Lett / The neurotrophins NGF and NT-3 reduce sensory neuronal loss in adult rat after peripheral nerve lesion. by Ljunberg (1999)
10.1016/S0304-3959(97)00063-8 / Pain / The inhibition of nitric oxide-activated poly (ADP-ribose) synthetase attenuates transsynaptic alteration of spinal cord dorsal horn neurons and neuropathic pain in the rat. by Mao (1997)
10.1016/S0006-8993(97)00061-9 / Brain Res / The release of immunoreactive neuropeptide Y in the spinal cord of the anaesthetized rat and cat. by Mark (1997)
10.1523/JNEUROSCI.14-03-01262.1994 / J Neurosci / Brain-derived neurotrophic factor and neurotrophin-3 activate striatal dopamine and serotonin metabolism and related behaviors: interactions with amphetamine. by Martin-Iverson (1994)
10.1016/0896-6273(94)90323-9 / Neuron / Expression and coexpression of trk receptors in subpopulations of adult primary sensory neurons projecting to identified peripheral targets. by McMahon (1994)
10.1523/JNEUROSCI.17-21-08476.1997 / J Neurosci / Nerve growth factor treatment increases brain-derived neurotrophic factor selectively in TrkA-expressing dorsal root ganglion cells and in their central terminations within the spinal cord. by Michael (1997)
10.1016/0304-3959(94)90184-8 / Pain / Serotonin and pain: evidence that activation of 5-HT1A receptors does not elicit antinociception against noxious thermal, mechanical and chemical stimuli in mice. by Millan (1994)
10.1016/S0301-0082(98)00048-3 / Prog Neurobiol / The induction of pain: an integrative review. by Millan (1999)
10.1006/dbio.1994.1250 / Dev Biol / Brain-derived neurotrophic factor promotes differentiation of striatal GABAergic neurons. by Mizuno (1994)
10.1097/00000542-199409000-00004 / Anesthesiology / Intrathecal and epidural somatostatin for patients with cancer. Analgesic effects and postmortem neuropathologic investigations of spinal cord and nerve roots. by Mollenholt (1994)
10.1016/S0006-8993(96)01026-8 / Brain Res / Neuropeptide changes persist in spinal cord despite resolving hyperalgesia in a rat model of neuropathy. by Munglani (1996)
10.1111/j.1471-4159.1993.tb03216.x / J Neurochem / Regulation of neuropeptide expression in cultured cerebral cortical neurons by brain-derived neurotrophic factor. by Nawa (1993)
10.1523/JNEUROSCI.14-06-03751.1994 / J Neurosci / Intraventricular administration of BDNF increases neuropeptide expression in newborn rat brain. by Nawa (1994)
10.1111/j.1460-9568.1997.tb01706.x / Eur J Neurosci / Effects of neurotransplants and BDNF on the survival and regeneration of injured adult spinal motorneurons. by Novikova (1997)
10.1016/0306-4522(93)90112-S / Neuroscience / Response of embryonic rat hippocampal neurons in culture to neurotropin-3, brain-derived neurotrophic factor and basic fibroblast factor. by Ohsawa (1993)
10.1152/jn.1997.78.1.31 / J Neurophysiol / Differential effects of NGF and BDNF on axotomy-induced changes in GABA (A)-receptor-mediated conductance and sodium currents in cutaneous afferent neurons. by Oyelese (1997)
{'key': 'R85-24-20210112', 'first-page': '409', 'article-title': 'A method for measurement of analgesic activity on inflamed tissue.', 'volume': '4', 'author': 'Randall', 'year': '1957', 'journal-title': 'Arch Int Pharmacodyn'} / Arch Int Pharmacodyn / A method for measurement of analgesic activity on inflamed tissue. by Randall (1957)
{'key': 'R86-24-20210112', 'first-page': '331', 'article-title': 'Retinal ganglion cell survival and axon elongation in cultures of embryonic rat retina not dependent upon brain-derived neurotrophic factor (abstract).', 'volume': '23', 'author': 'Rosano', 'year': '1997', 'journal-title': 'Soc Neurosci Abstr'} / Soc Neurosci Abstr / Retinal ganglion cell survival and axon elongation in cultures of embryonic rat retina not dependent upon brain-derived neurotrophic factor (abstract). by Rosano (1997)
10.1016/S0896-6273(00)80563-2 / Neuron / BDNF has opposite effects on the quantal amplitude of pyramidal neuron and interneuron excitatory synapses. by Rutherford (1998)
10.1007/BF00248557 / Exp Brain Res / Alterations in nociception following adrenal medullary transplants into the periaqueductal gray. by Sagen (1987)
10.1016/0896-6273(92)90183-E / Neuron / Novel roles for neurotrophins are suggested by BDNF and NT-3 mRNA expression in developing neurons. by Schectersom (1992)
10.1007/BF00242182 / Exp Brain Res / Transplantation of embryonic retinal donor cells labelled with BrdU or carrying a genetic marker to adult retina. by Seiler (1995)
10.1002/(SICI)1097-4695(19990215)38:3<391::AID-NEU8>3.0.CO;2-4 / J Neurobiol / Neurite outgrowth from progeny of epidermal growth factor-responsive hippocampal stem cells is significantly less robust that from fetal hippocampal cells following grafting onto organotypic hippocampal slice cultures: effect of brain-derived neurotrophic factor. by Shetty (1999)
10.1016/0006-8993(94)91556-3 / Brain Res / Antinociceptive effect of brain-derived neurotrophic factor and neurotrophin-3. by Siuciak (1994)
10.1046/j.1471-4159.1998.70051859.x / J Neurochem / Neurotrophins rescue cerebellar granule neurons from oxidative stress-mediated apoptotic death: selective involvement of phosphatidylinositol 3-kinase and the mitogen-activated protein kinase pathway. by Skaper (1998)
10.1023/A:1022434209787 / Neurochem Res / Expression of mRNAs for neurotrophins (NGF, BDNF, and NT-3) and their receptors (p75NGFR, trk, trkB, and trkC) in human peripheral neuropathies. by Sobue (1998)
10.1006/exnr.1995.1007 / Exp Neurol / Effects of BDNF on dopaminergic, serotonergic, and GABA ergic neurons in cultures of human fetal ventral mesencephalon. by Spenger (1995)
10.1016/S0028-3908(98)00189-0 / Neuropharmacology / BDNF and NT-3 but not CNTF counteract the Ca2 ionophore-induced apoptosis of cultured cortical neurons: involvement of dual pathways. by Takei (1999)
10.1073/pnas.96.14.7714 / Proc Natl Acad Sci USA / Brain-derived neurotrophic factor is an endogenous modulator of nociceptive responses in the spinal cord. by Thompson (1999)
10.1046/j.1471-4159.1999.0720102.x / J Neurochem / Evidence that brain-derived neurotrophic factor neuroprotection is linked to its ability to reverse the NMDA-induced inactivation of protein kinase C in cortical neurons. by Trembly (1999)
10.1007/s004410050989 / Cell Tissue Res / A truncated SV40 large T antigen lacking the p53 binding domain overcomes p53-induced growth arrest and immortalizes primary mesencephalic cells. by Truckenmiller (1998)
10.1016/0006-8993(92)90206-O / Brain Res / Effects of peripheral nerve injuries and tissue inflammation on the levels of neuropeptide Y-like immunoreactivity in rat primary sensory afferent neurons. by Wakisaka (1992)
10.1523/JNEUROSCI.14-11-06744.1994 / J Neurosci / Distinct regulatory pathways control neurofilament expression and neurotransmitter synthesis in immortalized serotonergic neurons. by White (1994)
10.1016/0006-8993(93)91111-5 / Brain Res / Target regulation of neuronal differentiation in a temperature-sensitive cell line derived from medullary raphe. by Whittemore (1993)
10.1097/00000542-199310000-00004 / Anesthesiology / Subarachnoid adrenal medullary transplants for terminal cancer pain. by Winnie (1993)
{'key': 'R106-24-20210112', 'first-page': '124', 'article-title': 'A combination of BDNF and NT-3 promotes supraspinal axonal regeneration into Schwann cell grafts in adult rat thoracic spinal cord.', 'volume': '168', 'author': 'Xu', 'year': '1995', 'journal-title': 'Dev Biol'} / Dev Biol / A combination of BDNF and NT-3 promotes supraspinal axonal regeneration into Schwann cell grafts in adult rat thoracic spinal cord. by Xu (1995)
10.1016/0304-3959(89)90160-7 / Pain / Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: effects of modulatory receptor systems and excitatory amino acid antagonists. by Yaksh (1989)
{'key': 'R108-24-20210112', 'first-page': '446', 'article-title': 'Spinal serotonin terminal system mediates antinociception.', 'volume': '208', 'author': 'Yaksh', 'year': '1979', 'journal-title': 'J Pharm Exp Ther'} / J Pharm Exp Ther / Spinal serotonin terminal system mediates antinociception. by Yaksh (1979)
10.1016/0304-3959(93)90102-U / Pain / Effects of intrathecal strychnine and bicuculline on nerve compression-induced thermal hyperalgesia and selective antagonism by MK-801. by Yamamoto (1993)
10.1002/ar.1092410415 / Anat Rec / Distribution of somatostatin mRNA containing neurons in the primary pain relaying nuclei of the rat. by Yin (1995)
10.1016/0165-0270(87)90098-7 / J Neurosci Methods / A new double labelling immunofluorescence technique for the determination of proliferation of human astrocytes in culture. by Yong (1987)
10.1016/0169-328X(95)00281-V / Brain Res Mol Brain Res / Neuronal coexistence of trkB and glutamic acid decarboxylase67 mRNAs in rat hippocampus. by Zachrisson (1996)
10.1016/0006-8993(94)91383-8 / Brain Res / Decreased GABA immunoreactivity in spinal cord dorsal horn neurons after transient spinal cord ischemia in the rat. by Zhang (1994)
10.1016/0167-0115(94)90131-7 / Reg Pep / Changes of spinal substance P, calcitonin gene-related peptides, somatostatin, Met-enkephalin and neurotensin in rats in response to formalin-induced pain. by Zhang (1994)
10.1016/0306-4522(96)00237-0 / Neuroscience / Endogenous brain-derived neurotrophic factor is anterogradely transported in primary sensory neurons. by Zhou (1996)
10.1016/0304-3959(83)90201-4 / Pain / Ethical guidelines for investigations of experimental pain in conscious animals. by Zimmermann (1983)

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 10:26 p.m.)
Deposited	4 years, 2 months ago (June 14, 2021, 5:56 p.m.)
Indexed	3 months, 3 weeks ago (May 6, 2025, 9:51 p.m.)
Issued	25 years, 4 months ago (May 1, 2000)
Published	25 years, 4 months ago (May 1, 2000)
Published Print	25 years, 4 months ago (May 1, 2000)

Funders 0

None

BibTeX

@article{Cejas_2000, title={Lumbar transplant of neurons genetically modified to secrete brain-derived neurotrophic factor attenuates allodynia and hyperalgesia after sciatic nerve constriction}, volume={86}, ISSN={0304-3959}, url={http://dx.doi.org/10.1016/s0304-3959(00)00245-1}, DOI={10.1016/s0304-3959(00)00245-1}, number={1}, journal={Pain}, publisher={Ovid Technologies (Wolters Kluwer Health)}, author={Cejas, P. J. and Martinez, M. and Karmally, S. and McKillop, M. and McKillop, J. and Plunkett, J. A. and Oudega, M. and Eaton, M. J.}, year={2000}, month=may, pages={195–210} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        5,
        7
      ]
    ],
    "date-time": "2025-05-07T01:51:45Z",
    "timestamp": 1746582705303
  },
  "reference-count": 111,
  "publisher": "Ovid Technologies (Wolters Kluwer Health)",
  "issue": "1",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2000,
        5
      ]
    ]
  },
  "DOI": "10.1016/s0304-3959(00)00245-1",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        7,
        26
      ]
    ],
    "date-time": "2002-07-26T02:26:40Z",
    "timestamp": 1027650400000
  },
  "page": "195-210",
  "source": "Crossref",
  "is-referenced-by-count": 98,
  "title": "Lumbar transplant of neurons genetically modified to secrete brain-derived neurotrophic factor attenuates allodynia and hyperalgesia after sciatic nerve constriction",
  "prefix": "10.1097",
  "volume": "86",
  "author": [
    {
      "given": "P. J.",
      "family": "Cejas",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "M.",
      "family": "Martinez",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "S.",
      "family": "Karmally",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "M.",
      "family": "McKillop",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "J.",
      "family": "McKillop",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "J. A.",
      "family": "Plunkett",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "M.",
      "family": "Oudega",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "M. J.",
      "family": "Eaton",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "276",
  "reference": [
    {
      "key": "R1-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "450",
      "DOI": "10.1038/374450a0",
      "article-title": "A BDNF autocrine loop in adult sensory neurons prevents cell death.",
      "volume": "374",
      "author": "Acheson",
      "year": "1995",
      "journal-title": "Nature"
    },
    {
      "key": "R2-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "1222",
      "DOI": "10.1038/2021222a0",
      "article-title": "Spinal reflexes and monoamine liberation.",
      "volume": "202",
      "author": "Anden",
      "year": "1964",
      "journal-title": "Nature"
    },
    {
      "key": "R3-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "1707",
      "DOI": "10.1111/j.1460-9568.1996.tb01314.x",
      "article-title": "Effects of BDNF and NT45 on striatonigral neuropeptides or nigral GABA neurons in vivo.",
      "volume": "8",
      "author": "Arenas",
      "year": "1996",
      "journal-title": "Eur J Neurosci"
    },
    {
      "key": "R4-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "87",
      "DOI": "10.1016/0304-3959(88)90209-6",
      "article-title": "A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man.",
      "volume": "33",
      "author": "Bennett",
      "year": "1988",
      "journal-title": "Pain"
    },
    {
      "key": "R6-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "310",
      "DOI": "10.1006/exnr.1997.6730",
      "article-title": "Transplantation of cryopreserved human embryonal carcinoma-derived (NT2N cells) promotes functional recovery in ischemic rats.",
      "volume": "149",
      "author": "Borlongan",
      "year": "1998",
      "journal-title": "Exp Neurol"
    },
    {
      "key": "R7-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "7953",
      "DOI": "10.1523/JNEUROSCI.18-19-07953.1998",
      "article-title": "Brain-derived neurotrophic factor and basic fibroblast growth factor downregulate NMDA receptor function in cerebellar granule cells.",
      "volume": "18",
      "author": "Brandoli",
      "year": "1998",
      "journal-title": "J Neurosci"
    },
    {
      "key": "R8-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "65",
      "DOI": "10.1016/0006-8993(89)90144-3",
      "article-title": "Survival and growth of hippocampal neurons in defined medium at low density: advantages of a sandwich culture technique or low oxygen.",
      "volume": "494",
      "author": "Brewer",
      "year": "1989",
      "journal-title": "Brain Res"
    },
    {
      "key": "R9-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "613",
      "DOI": "10.1515/BC.1999.078",
      "article-title": "Adeno-associated viral vectors for gene transfer and gene therapy.",
      "volume": "380",
      "author": "Bueler",
      "year": "1999",
      "journal-title": "Biol Chem"
    },
    {
      "key": "R10-24-20210112",
      "first-page": "1945",
      "article-title": "A BDNF-synthesizing cell line ameliorates chronic neuropathic pain (abstract).",
      "volume": "25",
      "author": "Cejas",
      "year": "1999",
      "journal-title": "Soc Neurosci Abstr"
    },
    {
      "key": "R11-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "55",
      "DOI": "10.1016/0165-0270(94)90144-9",
      "article-title": "Quantitative assessment of tactile allodynia in the rat paw.",
      "volume": "53",
      "author": "Chaplan",
      "year": "1994",
      "journal-title": "J Neurosci Methods"
    },
    {
      "key": "R12-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "147",
      "DOI": "10.1016/0143-4179(92)90115-D",
      "article-title": "The effects of sandostatin and somatostatin on nociceptive transmission in the dorsal horn of the rat spinal cord.",
      "volume": "237",
      "author": "Chapman",
      "year": "1992",
      "journal-title": "Neuropeptides"
    },
    {
      "key": "R13-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "269",
      "DOI": "10.1016/S0006-8993(97)00597-0",
      "article-title": "Increased brain-derived neurotrophic factor immunoreactivity in rat dorsal root ganglia and spinal cord following peripheral inflammation.",
      "volume": "764",
      "author": "Cho",
      "year": "1997",
      "journal-title": "Brain Res"
    },
    {
      "key": "R14-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "358",
      "DOI": "10.1016/S0006-8993(97)00048-6",
      "article-title": "Expression of mRNA for brain-derived neurotrophic factor in the dorsal root ganglion following peripheral inflammation.",
      "volume": "749",
      "author": "Cho",
      "year": "1997",
      "journal-title": "Brain Res"
    },
    {
      "key": "R15-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "224",
      "DOI": "10.1006/exnr.1998.6936",
      "article-title": "Changes in brain-derived neurotrophic factor immunoreactivity in rat dorsal root ganglia, spinal cord, and gracile nuclei following cut or crush injuries.",
      "volume": "154",
      "author": "Cho",
      "year": "1998",
      "journal-title": "Exp Neurol"
    },
    {
      "key": "R16-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "2295",
      "DOI": "10.1523/JNEUROSCI.17-07-02295.1997",
      "article-title": "Distribution of brain-derived neurotrophic factor (BDNF) protein and mRNA in the normal adult rat CNS: evidence for anterograde axonal transport.",
      "volume": "17",
      "author": "Conner",
      "year": "1997",
      "journal-title": "J Neurosci"
    },
    {
      "key": "R17-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "91",
      "DOI": "10.1515/REVNEURO.1998.9.2.91",
      "article-title": "Anterograde transport of neurotropin proteins in the CNS - a reassessment of the neurotropic hypothesis.",
      "volume": "9",
      "author": "Conner",
      "year": "1998",
      "journal-title": "Rev Neurosci"
    },
    {
      "key": "R18-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "1343",
      "DOI": "10.1111/j.1460-9568.1994.tb00325.x",
      "article-title": "Regulation of neuropeptides in adult rat forebrain by the neurotrophins BDNF and NGF.",
      "volume": "6",
      "author": "Croll",
      "year": "1994",
      "journal-title": "Eur J Neurosci"
    },
    {
      "key": "R19-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "507",
      "DOI": "10.1016/0301-0082(95)00011-J",
      "article-title": "Update on cellular transplantation into the CNS as a novel therapy for chronic pain.",
      "volume": "46",
      "author": "Czech",
      "year": "1995",
      "journal-title": "Prog Neurobiol"
    },
    {
      "key": "R20-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "399",
      "DOI": "10.1016/0006-8993(81)90018-4",
      "article-title": "5-Hydroxytryptamine reduces substance P responses on dorsal interneurones: a possible interaction of neurotransmitters.",
      "volume": "217",
      "author": "Davies",
      "year": "1981",
      "journal-title": "Brain Res"
    },
    {
      "key": "R21-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "633",
      "DOI": "10.1016/S0306-3623(96)00359-X",
      "article-title": "The pharmacology of excitatory and inhibitory amino acid-mediated events in the transmission and modulation of pain in the spinal cord.",
      "volume": "28",
      "author": "Dickenson",
      "year": "1997",
      "journal-title": "Gen Pharm"
    },
    {
      "key": "R22-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "733",
      "DOI": "10.1016/0306-4522(91)90092-3",
      "article-title": "Microinjection of neuropeptide Y into the superficial dorsal horn reduces stimulus-evoked release of immunoreactive substance P in the anesthetized cat.",
      "volume": "44",
      "author": "Duggan",
      "year": "1991",
      "journal-title": "Neuroscience"
    },
    {
      "key": "R23-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "105",
      "DOI": "10.1006/exnr.1996.0121",
      "article-title": "Autocrine BDNF secretion enhances the survival and serotonergic differentiation of raphe neuronal precursor cells grafted into the adult rat CNS.",
      "volume": "140",
      "author": "Eaton",
      "year": "1996",
      "journal-title": "Exp Neurol"
    },
    {
      "key": "R24-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "16195",
      "DOI": "10.1016/S0021-9258(17)46207-7",
      "article-title": "Immunohistochemical characterization of brain synaptic membrane glutamate-binding proteins.",
      "volume": "265",
      "author": "Eaton",
      "year": "1990",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "R25-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "169",
      "DOI": "10.1006/dbio.1995.1205",
      "article-title": "Developmental regulation of early serotonergic neuronal differentiation: the role of brain-derived neurotrophic factor and membrane depolarization.",
      "volume": "170",
      "author": "Eaton",
      "year": "1995",
      "journal-title": "Dev Biol"
    },
    {
      "key": "R26-24-20210112",
      "first-page": "1455",
      "article-title": "Autocrine BDNF secretion enhances the survival and serotonergic differentiation of grafted raphe neuronal precursor cells and lumbar transplants alleviate chronic neuropathic pain (abstract).",
      "volume": "23",
      "author": "Eaton",
      "year": "1996",
      "journal-title": "Soc Neurosci Abstr"
    },
    {
      "key": "R27-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "59",
      "DOI": "10.1016/S0304-3959(97)00015-8",
      "article-title": "Lumbar transplants of immortalized serotonergic neurons alleviates chronic neuropathic pain.",
      "volume": "72",
      "author": "Eaton",
      "year": "1997",
      "journal-title": "Pain"
    },
    {
      "key": "R28-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "57",
      "DOI": "10.1016/S0891-0618(98)00062-3",
      "article-title": "Changes in GAD and GABA immunoreactivity in the spinal dorsal horn after peripheral nerve injury and promotion of recovery by lumbar transplant of immortalized serotonergic neurons.",
      "volume": "16",
      "author": "Eaton",
      "year": "1998",
      "journal-title": "J Chem Neuroanat"
    },
    {
      "key": "R29-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "334",
      "DOI": "10.1016/S0006-8993(99)01564-4",
      "article-title": "A single dose of intrathecal GABA permanently reverses neuropathic pain after nerve injury.",
      "volume": "835",
      "author": "Eaton",
      "year": "1999",
      "journal-title": "Brain Res"
    },
    {
      "key": "R30-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "87",
      "DOI": "10.1177/096368979900800102",
      "article-title": "Transplants of neuronal cells bio-engineered to synthesize GABA alleviate chronic neuropathic pain.",
      "volume": "8",
      "author": "Eaton",
      "year": "1999",
      "journal-title": "Cell Transplant"
    },
    {
      "key": "R32-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "511",
      "DOI": "10.1016/0896-6273(90)90090-3",
      "article-title": "Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor family.",
      "volume": "5",
      "author": "Enfors",
      "year": "1990",
      "journal-title": "Neuron"
    },
    {
      "key": "R33-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "217",
      "DOI": "10.1016/0169-328X(93)90005-A",
      "article-title": "Expression of mRNAs for neurotrophin receptors in the dorsal root ganglion and spinal cord during development and following peripheral or central axotomy.",
      "volume": "17",
      "author": "Enfors",
      "year": "1993",
      "journal-title": "Brain Res Mol Brain Res"
    },
    {
      "key": "R34-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "2808",
      "DOI": "10.1523/JNEUROSCI.18-08-02808.1998",
      "article-title": "Functional evidence that BDNF is an anterograde neuronal trophic factor in the CNS.",
      "volume": "18",
      "author": "Fawcett",
      "year": "1998",
      "journal-title": "J Neurosci"
    },
    {
      "key": "R35-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "62",
      "DOI": "10.1006/exnr.1997.6440",
      "article-title": "Effects of BDNF infusion on the regulation of TrkB protein and message in adult rat brain.",
      "volume": "145",
      "author": "Frank",
      "year": "1997",
      "journal-title": "Exp Neurol"
    },
    {
      "key": "R36-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "11282",
      "DOI": "10.1073/pnas.89.23.11282",
      "article-title": "Increased levels of trkB mRNA and trkB protein-like immunoreactivity in the injured rat and cat spinal cord.",
      "volume": "89",
      "author": "Frisen",
      "year": "1992",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "R37-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "13",
      "DOI": "10.1016/S0304-3959(98)00111-0",
      "article-title": "Change in mRNAs for neuropeptides and the GABA(A) receptor in dorsal root ganglion neurons in a rat experimental neuropathic pain model.",
      "volume": "78",
      "author": "Fukuoka",
      "year": "1998",
      "journal-title": "Pain"
    },
    {
      "key": "R38-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "455",
      "DOI": "10.1083/jcb.123.2.455",
      "article-title": "Differential expression of the mRNA for neurotrophins and their receptors after axotomy of the sciatic nerve.",
      "volume": "123",
      "author": "Funakoshi",
      "year": "1993",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "R39-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "225",
      "DOI": "10.1177/096368979600500211",
      "article-title": "Cell-mediated delivery of brain-derived neurotrophic factor enhances dopamine levels in an MPP rat model of substantia nigra degeneration.",
      "volume": "5",
      "author": "Galpern",
      "year": "1996",
      "journal-title": "Cell Transplant"
    },
    {
      "key": "R40-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "262",
      "DOI": "10.1002/(SICI)1097-0029(19990515/01)45:4/5<262::AID-JEMT10>3.0.CO;2-K",
      "article-title": "Are there differences between secretion characteristics of NGF and BDNF? Implications for the modulatory role of neurotrophins in activity-dependent neuronal plasticity.",
      "volume": "45",
      "author": "Griesbeck",
      "year": "1999",
      "journal-title": "Microsci Res Tech"
    },
    {
      "key": "R41-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "279",
      "DOI": "10.1016/0304-3959(92)90070-R",
      "article-title": "Chronic pain related syndrome in rats after ischemic spinal cord lesion: a possible animal model for pain in patients with spinal cord injury.",
      "volume": "48",
      "author": "Hao",
      "year": "1992",
      "journal-title": "Pain"
    },
    {
      "key": "R42-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "77",
      "DOI": "10.1016/0304-3959(88)90026-7",
      "article-title": "A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia.",
      "volume": "32",
      "author": "Hargreaves",
      "year": "1988",
      "journal-title": "Pain"
    },
    {
      "key": "R43-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "7",
      "DOI": "10.1016/0306-4522(96)00196-0",
      "article-title": "Upregulation of spinal glutamate receptors in chronic pain.",
      "volume": "74",
      "author": "Harris",
      "year": "1996",
      "journal-title": "Neuroscience"
    },
    {
      "key": "R44-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "137",
      "DOI": "10.1016/0304-3940(95)11345-2",
      "article-title": "Inhibition of spinal nociceptive neurons by microinjections of somatostatin into the nucleus raphe magnus and the midbrain periaqueductal gray of the anesthetized cat.",
      "volume": "187",
      "author": "Helmchen",
      "year": "1995",
      "journal-title": "Neurosci Lett"
    },
    {
      "key": "R45-24-20210112",
      "first-page": "319",
      "article-title": "A reversible immortalization procedure to obtain neural cell lines (abstract).",
      "volume": "23",
      "author": "Herman",
      "year": "1997",
      "journal-title": "Soc Neurosci Abstr"
    },
    {
      "key": "R46-24-20210112",
      "first-page": "1539",
      "article-title": "Characterization of mesencephalic cell lines created by a reversible immortalization procedure (abstract).",
      "volume": "25",
      "author": "Herman",
      "year": "1999",
      "journal-title": "Soc Neurosci Abstr"
    },
    {
      "key": "R47-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "893",
      "DOI": "10.1016/0306-4522(88)90076-0",
      "article-title": "Locus coeruleus neurons in the rat containing neuropeptide Y, tyrosine hydroxylase, or galanin and their efferent projections to the spinal cord, cerebral cortex, and hypothalamus.",
      "volume": "24",
      "author": "Holets",
      "year": "1988",
      "journal-title": "Neuroscience"
    },
    {
      "key": "R48-24-20210112",
      "first-page": "243",
      "article-title": "The antinociceptive effects of spinally administered neuropeptide Y in the rat: systemic studies on structure-activity relationship.",
      "volume": "258",
      "author": "Hua",
      "year": "1991",
      "journal-title": "J Pharm Exp Ther"
    },
    {
      "key": "R49-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "15",
      "DOI": "10.1016/S0304-3959(96)03249-6",
      "article-title": "The effect of spinal GABA receptor agonists on tactile allodynia in a surgically-induced neuropathic pain model in the rat.",
      "volume": "70",
      "author": "Hwang",
      "year": "1997",
      "journal-title": "Pain"
    },
    {
      "key": "R50-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "335",
      "DOI": "10.1523/JNEUROSCI.14-01-00335.1994",
      "article-title": "Overlapping and distinct actions of the neurotrophins BDNF, NT-3, and NT-45 on cultured dopaminergic and GABAergic neurons of the ventral mesencephalon.",
      "volume": "14",
      "author": "Hyman",
      "year": "1994",
      "journal-title": "J Neurosci"
    },
    {
      "key": "R51-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1006/excr.1998.4272",
      "article-title": "SV40-mediated immortalization.",
      "volume": "245",
      "author": "Jha",
      "year": "1998",
      "journal-title": "Exp Cell Res"
    },
    {
      "key": "R52-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "241",
      "DOI": "10.1007/BF00618257",
      "article-title": "Staining with monoclonal antibodies to neurofilaments distinguishes between subpopulations of neurofibrillary tangles, between groups of axons and between groups of dendrites.",
      "volume": "234",
      "author": "Kahn",
      "year": "1987",
      "journal-title": "J Neurol"
    },
    {
      "key": "R53-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "85",
      "DOI": "10.1016/S0304-3959(96)03222-8",
      "article-title": "Involvement of increased excitatory amino acids and intracellular Ca2 concentration in the spinal dorsal horn in an animal model of neuropathic pain.",
      "volume": "68",
      "author": "Kawamata",
      "year": "1996",
      "journal-title": "Pain"
    },
    {
      "key": "R54-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "84",
      "DOI": "10.1016/0006-8993(86)91222-9",
      "article-title": "Cryopreservation of primary neurons for tissue culture.",
      "volume": "384",
      "author": "Kawamoto",
      "year": "1986",
      "journal-title": "Brain Res"
    },
    {
      "key": "R55-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "5138",
      "DOI": "10.1523/JNEUROSCI.19-12-05138.1999",
      "article-title": "Brain-derived neurotropic factor modulates nociceptive sensory inputs and NMDA-evoked responses in the rat spinal cord.",
      "volume": "19",
      "author": "Kerr",
      "year": "1999",
      "journal-title": "J Neurosci"
    },
    {
      "key": "R56-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "355",
      "DOI": "10.1016/0304-3959(92)90041-9",
      "article-title": "An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat.",
      "volume": "50",
      "author": "Kim",
      "year": "1992",
      "journal-title": "Pain"
    },
    {
      "key": "R57-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "2221",
      "DOI": "10.1097/00001756-199609020-00033",
      "article-title": "Treatment with genetically engineered fibroblasts producing NGF or BDNF can accelerate recovery from traumatic spinal cord injury in the adult rat.",
      "volume": "7",
      "author": "Kim",
      "year": "1996",
      "journal-title": "NeuroReport"
    },
    {
      "key": "R58-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "478",
      "DOI": "10.1016/0014-4886(88)90033-7",
      "article-title": "Diminished dorsal root GABA sensitivity following chronic peripheral nerve injury.",
      "volume": "100",
      "author": "Kingery",
      "year": "1988",
      "journal-title": "Exp Neurol"
    },
    {
      "key": "R59-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "477",
      "DOI": "10.1111/j.1365-2125.1983.tb02203.x",
      "article-title": "The analgesic effect of the GABA-agonist THIP in patients with chronic pain of malignant origin.",
      "volume": "16",
      "author": "Kjaer",
      "year": "1983",
      "journal-title": "Br J Clin Pharm"
    },
    {
      "key": "R60-24-20210112",
      "first-page": "738",
      "article-title": "Role of mouse neurotrophins in mouse neuronal development.",
      "volume": "8",
      "author": "Klein",
      "year": "1994",
      "journal-title": "Fed Am Soc Exp Biol J"
    },
    {
      "key": "R61-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "395",
      "DOI": "10.1016/0092-8674(91)90628-C",
      "article-title": "The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3.",
      "volume": "665",
      "author": "Klein",
      "year": "1991",
      "journal-title": "Cell"
    },
    {
      "key": "R63-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "359",
      "DOI": "10.1016/0896-6273(93)90326-M",
      "article-title": "Evidence that brain-derived neurotrophic factor is a trophic factor for motor neurons in vivo.",
      "volume": "10",
      "author": "Koliatsos",
      "year": "1993",
      "journal-title": "Neuron"
    },
    {
      "key": "R64-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "1362",
      "DOI": "10.1046/j.1471-4159.1996.66041362.x",
      "article-title": "Characterization of the responses of Purkinje cells to neurotrophin treatment.",
      "volume": "66",
      "author": "Larkfors",
      "year": "1996",
      "journal-title": "J Neurochem"
    },
    {
      "key": "R65-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "49",
      "DOI": "10.1016/S0304-3940(98)00958-6",
      "article-title": "Upregulation of brain-derived neurotrophic factor and neuropeptide Y in the dorsal ascending sensory pathway following sciatic nerve injury in rat.",
      "volume": "260",
      "author": "Li",
      "year": "1999",
      "journal-title": "Neurosci Lett"
    },
    {
      "key": "R66-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "45",
      "DOI": "10.1016/0306-4522(84)90136-2",
      "article-title": "Spinal cord contains neurotrophic activity for spinal sensory neurons. Late developmental appearance of a survival factor distinct from nerve growth factor.",
      "volume": "12",
      "author": "Lindsay",
      "year": "1984",
      "journal-title": "Neuroscience"
    },
    {
      "key": "R67-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "319",
      "DOI": "10.1016/0012-1606(85)90402-6",
      "article-title": "Placode and neural crest-derived sensory neurons responsive at early developmental stages to brain-derived neurotrophic factor.",
      "volume": "112",
      "author": "Lindsay",
      "year": "1985",
      "journal-title": "Dev Biol"
    },
    {
      "key": "R68-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "4370",
      "DOI": "10.1523/JNEUROSCI.19-11-04370.1999",
      "article-title": "Transplants of fibroblasts genetically modified to express BDNF promote regeneration of adult rat rubrospinal axons and recovery of forelimb function.",
      "volume": "19",
      "author": "Liu",
      "year": "1999",
      "journal-title": "J Neurosci"
    },
    {
      "key": "R69-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "29",
      "DOI": "10.1016/S0304-3940(99)00040-3",
      "article-title": "The neurotrophins NGF and NT-3 reduce sensory neuronal loss in adult rat after peripheral nerve lesion.",
      "volume": "262",
      "author": "Ljunberg",
      "year": "1999",
      "journal-title": "Neurosci Lett"
    },
    {
      "key": "R70-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "355",
      "DOI": "10.1016/S0304-3959(97)00063-8",
      "article-title": "The inhibition of nitric oxide-activated poly (ADP-ribose) synthetase attenuates transsynaptic alteration of spinal cord dorsal horn neurons and neuropathic pain in the rat.",
      "volume": "72",
      "author": "Mao",
      "year": "1997",
      "journal-title": "Pain"
    },
    {
      "key": "R71-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "195",
      "DOI": "10.1016/S0006-8993(97)00061-9",
      "article-title": "The release of immunoreactive neuropeptide Y in the spinal cord of the anaesthetized rat and cat.",
      "volume": "754",
      "author": "Mark",
      "year": "1997",
      "journal-title": "Brain Res"
    },
    {
      "key": "R72-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "1262",
      "DOI": "10.1523/JNEUROSCI.14-03-01262.1994",
      "article-title": "Brain-derived neurotrophic factor and neurotrophin-3 activate striatal dopamine and serotonin metabolism and related behaviors: interactions with amphetamine.",
      "volume": "14",
      "author": "Martin-Iverson",
      "year": "1994",
      "journal-title": "J Neurosci"
    },
    {
      "key": "R73-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "1161",
      "DOI": "10.1016/0896-6273(94)90323-9",
      "article-title": "Expression and coexpression of trk receptors in subpopulations of adult primary sensory neurons projecting to identified peripheral targets.",
      "volume": "12",
      "author": "McMahon",
      "year": "1994",
      "journal-title": "Neuron"
    },
    {
      "key": "R74-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "8476",
      "DOI": "10.1523/JNEUROSCI.17-21-08476.1997",
      "article-title": "Nerve growth factor treatment increases brain-derived neurotrophic factor selectively in TrkA-expressing dorsal root ganglion cells and in their central terminations within the spinal cord.",
      "volume": "17",
      "author": "Michael",
      "year": "1997",
      "journal-title": "J Neurosci"
    },
    {
      "key": "R75-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "45",
      "DOI": "10.1016/0304-3959(94)90184-8",
      "article-title": "Serotonin and pain: evidence that activation of 5-HT1A receptors does not elicit antinociception against noxious thermal, mechanical and chemical stimuli in mice.",
      "volume": "58",
      "author": "Millan",
      "year": "1994",
      "journal-title": "Pain"
    },
    {
      "key": "R76-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1016/S0301-0082(98)00048-3",
      "article-title": "The induction of pain: an integrative review.",
      "volume": "57",
      "author": "Millan",
      "year": "1999",
      "journal-title": "Prog Neurobiol"
    },
    {
      "key": "R77-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "243",
      "DOI": "10.1006/dbio.1994.1250",
      "article-title": "Brain-derived neurotrophic factor promotes differentiation of striatal GABAergic neurons.",
      "volume": "165",
      "author": "Mizuno",
      "year": "1994",
      "journal-title": "Dev Biol"
    },
    {
      "key": "R78-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "531",
      "DOI": "10.1097/00000542-199409000-00004",
      "article-title": "Intrathecal and epidural somatostatin for patients with cancer. Analgesic effects and postmortem neuropathologic investigations of spinal cord and nerve roots.",
      "volume": "81",
      "author": "Mollenholt",
      "year": "1994",
      "journal-title": "Anesthesiology"
    },
    {
      "key": "R79-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "102",
      "DOI": "10.1016/S0006-8993(96)01026-8",
      "article-title": "Neuropeptide changes persist in spinal cord despite resolving hyperalgesia in a rat model of neuropathy.",
      "volume": "743",
      "author": "Munglani",
      "year": "1996",
      "journal-title": "Brain Res"
    },
    {
      "key": "R80-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "772",
      "DOI": "10.1111/j.1471-4159.1993.tb03216.x",
      "article-title": "Regulation of neuropeptide expression in cultured cerebral cortical neurons by brain-derived neurotrophic factor.",
      "volume": "60",
      "author": "Nawa",
      "year": "1993",
      "journal-title": "J Neurochem"
    },
    {
      "key": "R81-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "3751",
      "DOI": "10.1523/JNEUROSCI.14-06-03751.1994",
      "article-title": "Intraventricular administration of BDNF increases neuropeptide expression in newborn rat brain.",
      "volume": "14",
      "author": "Nawa",
      "year": "1994",
      "journal-title": "J Neurosci"
    },
    {
      "key": "R82-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "2774",
      "DOI": "10.1111/j.1460-9568.1997.tb01706.x",
      "article-title": "Effects of neurotransplants and BDNF on the survival and regeneration of injured adult spinal motorneurons.",
      "volume": "9",
      "author": "Novikova",
      "year": "1997",
      "journal-title": "Eur J Neurosci"
    },
    {
      "key": "R83-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "67",
      "DOI": "10.1016/0306-4522(93)90112-S",
      "article-title": "Response of embryonic rat hippocampal neurons in culture to neurotropin-3, brain-derived neurotrophic factor and basic fibroblast factor.",
      "volume": "57",
      "author": "Ohsawa",
      "year": "1993",
      "journal-title": "Neuroscience"
    },
    {
      "key": "R84-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "31",
      "DOI": "10.1152/jn.1997.78.1.31",
      "article-title": "Differential effects of NGF and BDNF on axotomy-induced changes in GABA (A)-receptor-mediated conductance and sodium currents in cutaneous afferent neurons.",
      "volume": "78",
      "author": "Oyelese",
      "year": "1997",
      "journal-title": "J Neurophysiol"
    },
    {
      "key": "R85-24-20210112",
      "first-page": "409",
      "article-title": "A method for measurement of analgesic activity on inflamed tissue.",
      "volume": "4",
      "author": "Randall",
      "year": "1957",
      "journal-title": "Arch Int Pharmacodyn"
    },
    {
      "key": "R86-24-20210112",
      "first-page": "331",
      "article-title": "Retinal ganglion cell survival and axon elongation in cultures of embryonic rat retina not dependent upon brain-derived neurotrophic factor (abstract).",
      "volume": "23",
      "author": "Rosano",
      "year": "1997",
      "journal-title": "Soc Neurosci Abstr"
    },
    {
      "key": "R87-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "521",
      "DOI": "10.1016/S0896-6273(00)80563-2",
      "article-title": "BDNF has opposite effects on the quantal amplitude of pyramidal neuron and interneuron excitatory synapses.",
      "volume": "21",
      "author": "Rutherford",
      "year": "1998",
      "journal-title": "Neuron"
    },
    {
      "key": "R89-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "373",
      "DOI": "10.1007/BF00248557",
      "article-title": "Alterations in nociception following adrenal medullary transplants into the periaqueductal gray.",
      "volume": "67",
      "author": "Sagen",
      "year": "1987",
      "journal-title": "Exp Brain Res"
    },
    {
      "key": "R90-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "449",
      "DOI": "10.1016/0896-6273(92)90183-E",
      "article-title": "Novel roles for neurotrophins are suggested by BDNF and NT-3 mRNA expression in developing neurons.",
      "volume": "9",
      "author": "Schectersom",
      "year": "1992",
      "journal-title": "Neuron"
    },
    {
      "key": "R91-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "59",
      "DOI": "10.1007/BF00242182",
      "article-title": "Transplantation of embryonic retinal donor cells labelled with BrdU or carrying a genetic marker to adult retina.",
      "volume": "105",
      "author": "Seiler",
      "year": "1995",
      "journal-title": "Exp Brain Res"
    },
    {
      "key": "R92-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "391",
      "DOI": "10.1002/(SICI)1097-4695(19990215)38:3<391::AID-NEU8>3.0.CO;2-4",
      "article-title": "Neurite outgrowth from progeny of epidermal growth factor-responsive hippocampal stem cells is significantly less robust that from fetal hippocampal cells following grafting onto organotypic hippocampal slice cultures: effect of brain-derived neurotrophic factor.",
      "volume": "38",
      "author": "Shetty",
      "year": "1999",
      "journal-title": "J Neurobiol"
    },
    {
      "key": "R93-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "326",
      "DOI": "10.1016/0006-8993(94)91556-3",
      "article-title": "Antinociceptive effect of brain-derived neurotrophic factor and neurotrophin-3.",
      "volume": "63",
      "author": "Siuciak",
      "year": "1994",
      "journal-title": "Brain Res"
    },
    {
      "key": "R94-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "1859",
      "DOI": "10.1046/j.1471-4159.1998.70051859.x",
      "article-title": "Neurotrophins rescue cerebellar granule neurons from oxidative stress-mediated apoptotic death: selective involvement of phosphatidylinositol 3-kinase and the mitogen-activated protein kinase pathway.",
      "volume": "70",
      "author": "Skaper",
      "year": "1998",
      "journal-title": "J Neurochem"
    },
    {
      "key": "R95-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "821",
      "DOI": "10.1023/A:1022434209787",
      "article-title": "Expression of mRNAs for neurotrophins (NGF, BDNF, and NT-3) and their receptors (p75NGFR, trk, trkB, and trkC) in human peripheral neuropathies.",
      "volume": "23",
      "author": "Sobue",
      "year": "1998",
      "journal-title": "Neurochem Res"
    },
    {
      "key": "R96-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "50",
      "DOI": "10.1006/exnr.1995.1007",
      "article-title": "Effects of BDNF on dopaminergic, serotonergic, and GABA ergic neurons in cultures of human fetal ventral mesencephalon.",
      "volume": "133",
      "author": "Spenger",
      "year": "1995",
      "journal-title": "Exp Neurol"
    },
    {
      "key": "R98-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "283",
      "DOI": "10.1016/S0028-3908(98)00189-0",
      "article-title": "BDNF and NT-3 but not CNTF counteract the Ca2 ionophore-induced apoptosis of cultured cortical neurons: involvement of dual pathways.",
      "volume": "38",
      "author": "Takei",
      "year": "1999",
      "journal-title": "Neuropharmacology"
    },
    {
      "key": "R99-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "7714",
      "DOI": "10.1073/pnas.96.14.7714",
      "article-title": "Brain-derived neurotrophic factor is an endogenous modulator of nociceptive responses in the spinal cord.",
      "volume": "96",
      "author": "Thompson",
      "year": "1999",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "R100-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "102",
      "DOI": "10.1046/j.1471-4159.1999.0720102.x",
      "article-title": "Evidence that brain-derived neurotrophic factor neuroprotection is linked to its ability to reverse the NMDA-induced inactivation of protein kinase C in cortical neurons.",
      "volume": "72",
      "author": "Trembly",
      "year": "1999",
      "journal-title": "J Neurochem"
    },
    {
      "key": "R101-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "175",
      "DOI": "10.1007/s004410050989",
      "article-title": "A truncated SV40 large T antigen lacking the p53 binding domain overcomes p53-induced growth arrest and immortalizes primary mesencephalic cells.",
      "volume": "291",
      "author": "Truckenmiller",
      "year": "1998",
      "journal-title": "Cell Tissue Res"
    },
    {
      "key": "R102-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "349",
      "DOI": "10.1016/0006-8993(92)90206-O",
      "article-title": "Effects of peripheral nerve injuries and tissue inflammation on the levels of neuropeptide Y-like immunoreactivity in rat primary sensory afferent neurons.",
      "volume": "598",
      "author": "Wakisaka",
      "year": "1992",
      "journal-title": "Brain Res"
    },
    {
      "key": "R103-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "6744",
      "DOI": "10.1523/JNEUROSCI.14-11-06744.1994",
      "article-title": "Distinct regulatory pathways control neurofilament expression and neurotransmitter synthesis in immortalized serotonergic neurons.",
      "volume": "14",
      "author": "White",
      "year": "1994",
      "journal-title": "J Neurosci"
    },
    {
      "key": "R104-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "27",
      "DOI": "10.1016/0006-8993(93)91111-5",
      "article-title": "Target regulation of neuronal differentiation in a temperature-sensitive cell line derived from medullary raphe.",
      "volume": "615",
      "author": "Whittemore",
      "year": "1993",
      "journal-title": "Brain Res"
    },
    {
      "key": "R105-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "644",
      "DOI": "10.1097/00000542-199310000-00004",
      "article-title": "Subarachnoid adrenal medullary transplants for terminal cancer pain.",
      "volume": "79",
      "author": "Winnie",
      "year": "1993",
      "journal-title": "Anesthesiology"
    },
    {
      "key": "R106-24-20210112",
      "first-page": "124",
      "article-title": "A combination of BDNF and NT-3 promotes supraspinal axonal regeneration into Schwann cell grafts in adult rat thoracic spinal cord.",
      "volume": "168",
      "author": "Xu",
      "year": "1995",
      "journal-title": "Dev Biol"
    },
    {
      "key": "R107-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "111",
      "DOI": "10.1016/0304-3959(89)90160-7",
      "article-title": "Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: effects of modulatory receptor systems and excitatory amino acid antagonists.",
      "volume": "37",
      "author": "Yaksh",
      "year": "1989",
      "journal-title": "Pain"
    },
    {
      "key": "R108-24-20210112",
      "first-page": "446",
      "article-title": "Spinal serotonin terminal system mediates antinociception.",
      "volume": "208",
      "author": "Yaksh",
      "year": "1979",
      "journal-title": "J Pharm Exp Ther"
    },
    {
      "key": "R109-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "79",
      "DOI": "10.1016/0304-3959(93)90102-U",
      "article-title": "Effects of intrathecal strychnine and bicuculline on nerve compression-induced thermal hyperalgesia and selective antagonism by MK-801.",
      "volume": "54",
      "author": "Yamamoto",
      "year": "1993",
      "journal-title": "Pain"
    },
    {
      "key": "R110-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "579",
      "DOI": "10.1002/ar.1092410415",
      "article-title": "Distribution of somatostatin mRNA containing neurons in the primary pain relaying nuclei of the rat.",
      "volume": "241",
      "author": "Yin",
      "year": "1995",
      "journal-title": "Anat Rec"
    },
    {
      "key": "R111-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "9",
      "DOI": "10.1016/0165-0270(87)90098-7",
      "article-title": "A new double labelling immunofluorescence technique for the determination of proliferation of human astrocytes in culture.",
      "volume": "21",
      "author": "Yong",
      "year": "1987",
      "journal-title": "J Neurosci Methods"
    },
    {
      "key": "R112-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "169",
      "DOI": "10.1016/0169-328X(95)00281-V",
      "article-title": "Neuronal coexistence of trkB and glutamic acid decarboxylase67 mRNAs in rat hippocampus.",
      "volume": "36",
      "author": "Zachrisson",
      "year": "1996",
      "journal-title": "Brain Res Mol Brain Res"
    },
    {
      "key": "R113-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "187",
      "DOI": "10.1016/0006-8993(94)91383-8",
      "article-title": "Decreased GABA immunoreactivity in spinal cord dorsal horn neurons after transient spinal cord ischemia in the rat.",
      "volume": "656",
      "author": "Zhang",
      "year": "1994",
      "journal-title": "Brain Res"
    },
    {
      "key": "R114-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "25",
      "DOI": "10.1016/0167-0115(94)90131-7",
      "article-title": "Changes of spinal substance P, calcitonin gene-related peptides, somatostatin, Met-enkephalin and neurotensin in rats in response to formalin-induced pain.",
      "volume": "51",
      "author": "Zhang",
      "year": "1994",
      "journal-title": "Reg Pep"
    },
    {
      "key": "R115-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "945",
      "DOI": "10.1016/0306-4522(96)00237-0",
      "article-title": "Endogenous brain-derived neurotrophic factor is anterogradely transported in primary sensory neurons.",
      "volume": "74",
      "author": "Zhou",
      "year": "1996",
      "journal-title": "Neuroscience"
    },
    {
      "key": "R116-24-20210112",
      "doi-asserted-by": "crossref",
      "first-page": "109",
      "DOI": "10.1016/0304-3959(83)90201-4",
      "article-title": "Ethical guidelines for investigations of experimental pain in conscious animals.",
      "volume": "16",
      "author": "Zimmermann",
      "year": "1983",
      "journal-title": "Pain"
    }
  ],
  "container-title": "Pain",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://journals.lww.com/10.1016/S0304-3959(00)00245-1",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        6,
        14
      ]
    ],
    "date-time": "2021-06-14T21:56:36Z",
    "timestamp": 1623707796000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://journals.lww.com/00006396-200005010-00024"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2000,
        5
      ]
    ]
  },
  "references-count": 111,
  "journal-issue": {
    "issue": "1",
    "published-print": {
      "date-parts": [
        [
          2000
        ]
      ]
    }
  },
  "URL": "http://dx.doi.org/10.1016/S0304-3959(00)00245-1",
  "relation": {},
  "ISSN": [
    "0304-3959"
  ],
  "subject": [],
  "published": {
    "date-parts": [
      [
        2000,
        5
      ]
    ]
  }
}