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Neurochemistry International (78)
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Klein, W. L. (2002). Aβ toxicity in Alzheimer’s disease: globular oligomers (ADDLs) as new vaccine and drug targets. Neurochemistry International, 41(5), 345–352.

Authors 1
  1. William L Klein (first)
References 49 Referenced 449
  1. 10.1074/jbc.M102223200 / J. Biol. Chem. / Amyloid-beta-protein oligomerization: prenucleation interactions revealed by photo-induced cross-linking of unmodified proteins by Bitan (2001)
  2. 10.1016/0197-4580(92)90065-6 / Neurobiol. Aging / Methodological variables in the assessment of beta amyloid neurotoxicity by Busciglio (1992)
  3. {'issue': '11', 'key': '10.1016/S0197-0186(02)00050-5_BIB3', 'first-page': '322', 'article-title': 'Nonfibrillar Aβ toxins in AD: an immunoassay to characterize ADDL formation and identify ADDL-blocker compounds', 'volume': '27', 'author': 'Chang', 'year': '2001', 'journal-title': 'Soc. Neurosci. Abs.'} / Soc. Neurosci. Abs. / Nonfibrillar Aβ toxins in AD: an immunoassay to characterize ADDL formation and identify ADDL-blocker compounds by Chang (2001)
  4. Chromy, B.A., Nowak, R., Lambert, M.P., Viola, K.L., Chang, L., Stine, W.B., Priebe, G., Krafft, G.A., Klein, W.L., 2001. Self-assembly of Aβ 1–42 into globular neurotoxins (ADDLs). Biochemistry. (10.1021/bi030029q)
  5. Chui, D.H., Tanahashi, H., Ozawa, K., Ikeda, S., Checler, F., Ueda, O., Suzuki, H., Araki, W., Inoue, H., Shirotani, K., Takahashi, K., Gallyas, F., Tabira, T., 1999. Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation. Nat. Med. 5, 560–564. (10.1038/8438)
  6. Czech, C., Masters, C., Beyreuther, K., 1994. Alzheimer’s disease and transgenic mice. J. Neural Transm. Suppl. 44, 219–230. (10.1007/978-3-7091-9350-1_17)
  7. 10.1016/S0165-0173(00)00021-7 / Brain Res. Brain Res. Rev. / Wnt signaling function in Alzheimer’s disease by De Ferrari (2000)
  8. D’Hooge, R., Nagels, G., Westland, C.E., Mucke, L., De Deyn, P.P., 1996. Spatial learning deficit in mice expressing human 751-amino acid beta-amyloid precursor protein. Neuroreport 7, 2807–2811. (10.1097/00001756-199611040-00080)
  9. Dodart, J.C., Mathis, C., Bales, K.R., Paul, S.M., Ungerer, A., 2000. Behavioral deficits in APP(V717F) transgenic mice deficient for the apolipoprotein E gene. Neuroreport 11, 603–607. (10.1097/00001756-200002280-00034)
  10. {'issue': '10', 'key': '10.1016/S0197-0186(02)00050-5_BIB10', 'first-page': '322', 'article-title': 'Nonfibrillar Aβ toxins in Alzheimer’s pathogenesis: presence of ADDLs and ADDL-binding proteins in Alzheimer’s disease brains', 'volume': '27', 'author': 'Gong', 'year': '2001', 'journal-title': 'Soc. for Neurosci. Abs.'} / Soc. for Neurosci. Abs. / Nonfibrillar Aβ toxins in Alzheimer’s pathogenesis: presence of ADDLs and ADDL-binding proteins in Alzheimer’s disease brains by Gong (2001)
  11. 10.1523/JNEUROSCI.19-20-08876.1999 / J. Neurosci. / Protofibrillar intermediates of amyloid-beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons by Hartley (1999)
  12. Holcomb, L., Gordon, M.N., McGowan, E., Yu, X., Benkovic, S., Jantzen, P., Wright, K., Saad, I., Mueller, R., Morgan, D., Sanders, S., Zehr, C., O’Campo, K., Hardy, J., Prada, C.M., Eckman, C., Younkin, S., Hsiao, K., Duff, K., 1998. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat. Med. 4, 97–100. (10.1038/nm0198-097)
  13. Holcomb, L.A., Gordon, M.N., Jantzen, P., Hsiao, K., Duff, K., Morgan, D., 1999. Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits. Behav. Genet. 29, 177–185. (10.1023/A:1021691918517)
  14. Hsia, A.Y., Masliah, E., McConlogue, L., Yu, G.Q., Tatsuno, G., Hu, K., Kholodenko, D., Malenka, R.C., Nicoll, R.A., Mucke, L., 1999. Plaque-independent disruption of neural circuits in Alzheimer’s disease mouse models. Proc. Natl. Acad. Sci. U.S.A. 96, 3228–3233. (10.1073/pnas.96.6.3228)
  15. Klein, W.L., 2000. Aβ toxicity in Alzheimer’s Disease. In: Chesselet, M.F., (Ed.), Contemporary Clinical Neuroscience: Molecular Mechanisms of Neurodegenerative Diseases. Humana Press, Totowa, pp. 1–47. (10.1385/1-59259-006-3:1)
  16. 10.1016/S0166-2236(00)01749-5 / Trends Neurosci. / Targeting small Abeta oligomers: the solution to an Alzheimer’s disease conundrum? by Klein (2001)
  17. Kumar-Singh, S., Dewachter, I., Moechars, D., Lubke, U., De Jonghe, C., Ceuterick, C., Checler, F., Naidu, A., Cordell, B., Cras, P., Van Broeckhoven, C., Van Leuven, F., 2000. Behavioral disturbances without amyloid deposits in mice overexpressing human amyloid precursor protein with Flemish (A692G) or Dutch (E693Q) mutation. Neurobiol. Dis. 7, 9–22. (10.1006/nbdi.1999.0272)
  18. 10.1073/pnas.95.11.6448 / Proc. Natl. Acad. Sci. U.S.A. / Diffusible, nonfibrillar ligands derived from Abeta 1–42 are potent central nervous system neurotoxins by Lambert (1998)
  19. 10.1002/jnr.490390404 / J. Neurosci. Res. / Beta/A4-evoked degeneration of differentiated SH-SY5Y human neuroblastoma cells by Lambert (1994)
  20. 10.1046/j.1471-4159.2001.00592.x / J. Neurochem. / Vaccination with soluble Aβ oligomers generates toxicity-neutralizing antibodies by Lambert (2001)
  21. 10.1016/S0896-6273(00)80406-7 / Neuron / Structural neurology: are seeds at the root of neuronal degeneration? by Lansbury (1997)
  22. Larson, J., Lynch, G., Games, D., Seubert, P., 1999. Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice. Brain Res. 840, 23–35. (10.1016/S0006-8993(99)01698-4)
  23. 10.1046/j.1471-4159.1999.0720576.x / J. Neurochem. / Insulin transiently increases tau phosphorylation: involvement of glycogen synthase kinase-3beta and fyn tyrosine kinase by Lesort (1999)
  24. 10.1046/j.1471-4159.1997.69062285.x / J. Neurochem. / Cytotoxic amyloid peptides inhibit cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction by enhancing MTT formazan exocytosis by Liu (1997)
  25. 10.1046/j.1471-4159.2000.0751977.x / J. Neurochem. / Reversible inactivation of superoxide-sensitive aconitase in Aß 1–42-treated neuronal cell lines by Longo (2000)
  26. 10.1073/pnas.90.17.7951 / Proc. Natl. Acad. Sci. U.S.A. / Apoptosis is induced by beta-amyloid in cultured central nervous system neurons by Loo (1993)
  27. 10.1073/pnas.91.25.12243 / Proc. Natl. Acad. Sci. U.S.A. / Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red by Lorenzo (1994)
  28. 10.1016/S0002-9440(10)65184-X / Am. J. Pathol. / Soluble amyloid-beta peptide concentration as a predictor of synaptic change in Alzheimer’s disease by Lue (1999)
  29. 10.1002/(SICI)1097-4547(19991001)58:1<152::AID-JNR15>3.0.CO;2-V / J. Neurosci. Res. / Apoptotic biochemical cascades in synaptic compartments: roles in adaptive plasticity and neurodegenerative disorders by Mattson (1999)
  30. 10.1002/(SICI)1097-4547(19991001)58:1<42::AID-JNR6>3.0.CO;2-L / J. Neurosci. Res. / The plasticity-pathology continuum: defining a role for the LTP phenomenon by McEachern (1999)
  31. 10.1038/35050116 / Nature / Abeta peptide vaccination prevents memory loss in an animal model of Alzheimer’s disease by Morgan (2000)
  32. 10.1523/JNEUROSCI.20-11-04050.2000 / J. Neurosci. / High-level neuronal expression of Abeta 1–42 in wild-type human amyloid protein precursor transgenic-mice: synaptotoxicity without plaque formation by Mucke (2000)
  33. 10.1006/bbrc.1994.2580 / Biochem. Biophys. Res. Commun. / Purification and characterization of brain clusterin by Oda (1994)
  34. 10.1006/exnr.1995.1080 / Exp. Neurol. / Clusterin (Apoj) alters the aggregation of amyloid-beta-peptide (Abeta 1–42) and forms slowly sedimenting Abeta complexes that cause oxidative stress by Oda (1995)
  35. Pedersen, W.A. Culmsee, C., Ziegler, D., Herman, J.P., Mattson, M.P., 1999. Aberrant stress response associated with severe hypoglycemia in a transgenic mouse model of Alzheimer’s disease. J. Mol. Neurosci. 13, 159–165. (10.1385/JMN:13:1-2:159)
  36. 10.1523/JNEUROSCI.13-04-01676.1993 / J. Neurosci. / Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state by Pike (1993)
  37. 10.1038/22124 / Nature / Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse by Schenk (1999)
  38. 10.1097/00001756-199304000-00024 / Neuroreport / The protein tyrosine kinase, fyn, in Alzheimer’s disease pathology by Shirazi (1993)
  39. 10.1146/annurev.neuro.24.1.299 / Annu. Rev. Neurosci. / Protein synthesis at synaptic sites on dendrites by Steward (2001)
  40. 10.1007/BF01887400 / J. Protein Chem. / The nanometer-scale structure of amyloid-beta visualized by atomic force microscopy by Stine (1996)
  41. Terry, R.D., 1999. The neuropathology of Alzheimer disease and the structural basis of its cognitive alterations. In: Terry, R.D., Katzman, R., Bick, K.L., Sisodia, S.S. (Eds.), Alzheimer Disease. Lippincott Williams, and Wilkins, Philadelphia, PA, pp. 187–206.
  42. 10.1074/jbc.274.36.25945 / J. Biol. Chem. / Amyloid-beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates by Walsh (1999)
  43. 10.1074/jbc.272.35.22364 / J. Biol. Chem. / Amyloid-beta-protein fibrillogenesis: detection of a protofibrillar intermediate by Walsh (1997)
  44. Wang, H.-W., Pasternak, J.F., Kuo, H., Ristic, H., Lambert, M.P., Chromy, B., Viola, K.L., Klein, W.L., Stine, B., Krafft, G.A., Trommer, B.L., 2001. Soluble oligomers of β amyloid (1–42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus. Brain Res. (10.1016/S0006-8993(01)03058-X)
  45. Yamaguchi, F., Richards, S.J., Beyreuther, K., Salbaum, M., Carlson, G.A. Dunnett, S.B., 1991. Transgenic mice for the amyloid precursor protein 695 isoform have impaired spatial memory. Neuroreport 2, 781–784. (10.1097/00001756-199112000-00013)
  46. 10.1016/S0006-8993(00)03131-0 / Brain Res. / The Ginkgo biloba extract EGb 761 rescues the PC12 neuronal cells from beta-amyloid-induced cell death by inhibiting the formation of beta-amyloid-derived diffusible neurotoxic ligands by Yao (2001)
  47. 10.1016/S0928-4257(98)80035-1 / J. Physiol Paris / The role of Abeta 42 in Alzheimer’s disease by Younkin (1998)
  48. 10.1146/annurev.neuro.24.1.1071 / Annu. Rev. Neurosci. / Morphological changes in dendritic spines associated with long-term synaptic plasticity by Yuste (2001)
  49. 10.1016/0304-3940(96)12761-0 / Neurosci. Lett. / Abeta peptide enhances focal adhesion kinase/fyn association in a rat CNS nerve cell line by Zhang (1996)
Dates
Type When
Created 23 years ago (Aug. 26, 2002, 6:48 p.m.)
Deposited 5 years, 7 months ago (Jan. 8, 2020, 2:53 a.m.)
Indexed 1 month, 2 weeks ago (July 16, 2025, 8:44 a.m.)
Issued 22 years, 9 months ago (Nov. 1, 2002)
Published 22 years, 9 months ago (Nov. 1, 2002)
Published Print 22 years, 9 months ago (Nov. 1, 2002)
Funders 0

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@article{Klein_2002, title={Aβ toxicity in Alzheimer’s disease: globular oligomers (ADDLs) as new vaccine and drug targets}, volume={41}, ISSN={0197-0186}, url={http://dx.doi.org/10.1016/s0197-0186(02)00050-5}, DOI={10.1016/s0197-0186(02)00050-5}, number={5}, journal={Neurochemistry International}, publisher={Elsevier BV}, author={Klein, William L}, year={2002}, month=nov, pages={345–352} }