DOI: 10.1016/s0193-953x(18)30318-6. The Treatment of Cognitive Impairment in Alzheimer’s Disease: Beyond the Cholinergic Approach

The Treatment of Cognitive Impairment in Alzheimer’s Disease: Beyond the Cholinergic Approach

10.1016/s0193-953x(18)30318-6

Crossref journal-article

Elsevier BV

Psychiatric Clinics of North America (78)

Bibliography

Davidson, M., & Stem, R. G. (1991). The Treatment of Cognitive Impairment in Alzheimerâs Disease: Beyond the Cholinergic Approach. Psychiatric Clinics of North America, 14(2), 461â482.

Authors 2

Michael Davidson (first)
Robert G. Stem (additional)

References 178 Referenced 15

10.1523/JNEUROSCI.08-11-04287.1988 / J Neurosci / Goldman-Rakic PS: The alpha-2 adrenergic agonist guanfa-eine improves memory in aged monkeys without sedative or hypotensive side effects: Evidence for alpha-2 receptor subtypes by Arnstein (1988)
10.1111/j.1471-4159.1982.tb07930.x / J Neurochem / Angiotensin converting enzyme in Alz-heimer's disease: Increased activity in caudate nucleus and cortical areas by Arregui (1982)
{'key': '10.1016/S0193-953X(18)30318-6_bib3', 'series-title': "Treatment Development Strategies for Alzheimer's disease, Madison, Connecticut, Mark Powley Associates", 'first-page': '584', 'article-title': "Alzheimer's disease: Strategies for treatment and research", 'author': 'Bagne', 'year': '1986'} / Treatment Development Strategies for Alzheimer's disease, Madison, Connecticut, Mark Powley Associates / Alzheimer's disease: Strategies for treatment and research by Bagne (1986)
10.1126/science.7046051 / Science / The cholinergic hypothesis of geriatric memory dysfunction by Bartus (1982)
{'key': '10.1016/S0193-953X(18)30318-6_bib5', 'series-title': 'Psychopharmacology: The Third Generation of Progress', 'first-page': '219', 'article-title': 'Cholinergic psychopharmacology: An integration of human and animal research on memory', 'author': 'Bartus', 'year': '1987'} / Psychopharmacology: The Third Generation of Progress / Cholinergic psychopharmacology: An integration of human and animal research on memory by Bartus (1987)
10.1111/j.1749-6632.1985.tb37600.x / Ann NY Acad Sci / The cholinergic hypothesis: A histori-cal overview, current perspective and future directions by Bartus (1985)
10.1111/j.1600-0404.1988.tb07983.x / A comparison of various routes of administration. Acta Neurol Scand Suppl / Potential pharmacotherapy of Alzheimer's disease by Becker (1988)
{'key': '10.1016/S0193-953X(18)30318-6_bib8', 'first-page': '400', 'article-title': 'Long-term outpatient treatment of senile dementia with oral physostigmine', 'volume': '49', 'author': 'Beller', 'year': '1988', 'journal-title': 'J Clin Psychiatry'} / J Clin Psychiatry / Long-term outpatient treatment of senile dementia with oral physostigmine by Beller (1988)
10.1007/BF00436170 / Psychopharm-acology / Alaproclate: A pharmacokinetic and biochemical study in patients with dementia of Alzheimer's type by Bergmann (1983)
10.1212/WNL.39.1.76 / Neurology / Diagnosis of dementia: Clinicopathological correla-tions by Boller (1989)
10.1212/WNL.32.2.164 / Neurology / Loss of neurons of origin of the adrenergic projection to cerebral cortex (nucleus locus coeruleus) in senile dementia by Bondareff (1982)
10.1016/0166-2236(89)90054-4 / Trends Neurosci / The molecular basis of muscarinic receptor diversity by Bonner (1989)
10.1126/science.3037705 / Science / Identification of a family of muscarinic acetylcholine receptor genes by Bonner (1987)
{'key': '10.1016/S0193-953X(18)30318-6_bib14', 'series-title': 'Nimodipine: Pharmacological and Clinical Studies. Stuttgart, Schattauer', 'first-page': '275', 'article-title': 'Nimodipine in cCVD patients, clinical and neuropsychological results of a double-blind crossover study', 'author': 'Bono', 'year': '1985'} / Nimodipine: Pharmacological and Clinical Studies. Stuttgart, Schattauer / Nimodipine in cCVD patients, clinical and neuropsychological results of a double-blind crossover study by Bono (1985)
{'key': '10.1016/S0193-953X(18)30318-6_bib15', 'first-page': '266', 'article-title': "Biochemical assessment of serotonergic and cholinergic dysfunction and cerebral atrophy in Alzheimer's disease", 'volume': '41', 'author': 'Bowen', 'year': '1983', 'journal-title': 'J Neuro-chem'} / J Neuro-chem / Biochemical assessment of serotonergic and cholinergic dysfunction and cerebral atrophy in Alzheimer's disease by Bowen (1983)
{'key': '10.1016/S0193-953X(18)30318-6_bib16', 'first-page': '212', 'article-title': 'The efficacy of the cerebral metabolic enhancers in the treatment of senile dementia', 'volume': '19', 'author': 'Branconnier', 'year': '1983', 'journal-title': 'Psychopharmacol Bull'} / Psychopharmacol Bull / The efficacy of the cerebral metabolic enhancers in the treatment of senile dementia by Branconnier (1983)
{'key': '10.1016/S0193-953X(18)30318-6_bib17', 'first-page': '726', 'article-title': "The therapeutic efficacy of piracetam in Alzheimer's disease: Preliminary observations", 'volume': '19', 'author': 'Branconnier', 'year': '1983', 'journal-title': 'Psychopharmacol Bull'} / Psychopharmacol Bull / The therapeutic efficacy of piracetam in Alzheimer's disease: Preliminary observations by Branconnier (1983)
10.1016/0006-3223(89)91620-X / Biol Psychiatry / Murphy EA: Risk factor intervention in Alz-heimer's disease: Delay of onset by five years will halve morbidity [abstr] by Breitner (1989)
10.1016/S0197-4580(89)80015-6 / Neurobiol Aging / Production and characterization of biologically active recombinant human nerve growth factor by Bruce (1989)
10.1111/j.1432-1033.1986.tb09646.x / Eur J Biochem / Anticholinesterase activity of a new carbamate, heptylphysostigmine, in view of its use in patients with Alzheimer-type dementia by Brufani (1986)
10.1001/archneur.1986.00520070017009 / Arch Neurol / RS-86 therapy of Alzheimer's disease by Bruno (1985)
10.1016/S0026-895X(25)11261-3 / Mol Pharmacol / Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells by Buckley (1989)
10.1073/pnas.87.15.6003 / Proc Natl Acad Sci USA / Processing of Alzheimer ß/1/A4 amyloid precursor protein: Modulation by agents that regulate protein phosphorylation by Buxbaum (1990)
10.1136/bmj.300.6723.495 / BMJ / Tacrine Retrahydroaminoacridine(THA) and lecithin in senile dementia of the Alzheimer type: A multicentre trial by Chatellier (1990)
10.1192/bjp.138.1.46 / Br J Psychiatry / Physostigmine and arecoline: Effects of intravenous infusions in Alzheimer's presenile dementia by Christie (1981)
10.1016/0306-4522(86)90002-3 / Neuroscience / Cholinergic function and intellectual decline in Alzheimer's disease by Collerton (1986)
10.1002/ddr.430190308 / Drug Dev Res / Cognition enhancement by the acetylcholine releaser DuP 996 by Cook (1990)
10.1055/s-2007-1014678 / Pharmacopsychiatry / Herrmann VVM: Psychostimulants, analeptics, nootropics: An attempt to differentiate and assess drugs designed for the treatment of impaired brain functions by Coper (1988)
{'issue': '1', 'key': '10.1016/S0193-953X(18)30318-6_bib29', 'first-page': '47', 'article-title': 'Work performance, absenteeism and antihypertensive medications', 'volume': '5', 'author': 'Croog', 'year': '1987', 'journal-title': 'J Hypertens'} / J Hypertens / Work performance, absenteeism and antihypertensive medications by Croog (1987)
10.1007/BF00426708 / Psychopharmacology / The effect of methylphenidate on test performance in the cognitively impaired aged by Crook (1977)
10.1016/0197-4580(86)90019-9 / Neurobiol Aging / The selectivity of the reduction of serotonin S2 receptors in Alzheimertype dementia by Cross (1986)
10.1001/archneur.1985.04210090008003 / Arch Neurol / Evaluation of zimelidine in Alzheimer's disease: Cognitive and biochemical measures by Cutler (1985)
10.1056/NEJM198503143121113 / New Engl J Med / Evaluation of an analog of somatostatin (L363, 586) in Alzheimer's disease by Cutler (1985)
Dal-Bianco P, et al: AD -Therapie durch Cholinesterasehemmung. Presented at the 19th Central European Neurobiol Symposium -CNS, Vienna, June 29-July 1st, 1989
{'key': '10.1016/S0193-953X(18)30318-6_bib33', 'first-page': '1', 'article-title': 'Combined administration of physostig-mine and clonidine to patients with dementia of the Alzheimer type: A pilot safety study', 'volume': '1', 'author': 'Davidson', 'year': '1989', 'journal-title': 'Alzheimer Dis Assoc Disord'} / Alzheimer Dis Assoc Disord / Combined administration of physostig-mine and clonidine to patients with dementia of the Alzheimer type: A pilot safety study by Davidson (1989)
10.1016/0006-3223(87)90139-9 / Biol Psychiatry / Lecithin and piracetam in patients with Alzheimer's disease by Davidson (1987)
10.1016/0006-3223(88)90020-0 / Biol Psychiatry / 4-Aminopyridine in the treatment of Alzheimer's disease by Davidson (1988)
10.1016/S0140-6736(76)91936-X / Lancet / Selective loss of central cholinergic neurons in Alzheimer's disease by Davies (1976)
10.1176/ajp.144.4.468 / Am J Psychiatry / Induction of depression with oxotre-morine in Alzheimer's disease patients by Davis (1987)
10.1111/j.1600-0447.1985.tb01270.x / Acta Psychiatr Scand / A double-blind comparison of alaproclate and placebo in the treatment of patients with senile dementia by Dehlin (1985)
10.1016/S0166-2236(84)80157-5 / Trends Neurosci / The importance of vasopressin in memory by De Wied (1984)
10.1126/science.2916127 / Science / Nimodipine facilitates associative learning in aging rabbits by Deyo (1989)
10.1001/archneur.1974.00490320001001 / Arch Neurol / Human memory and the cholinergic system by Dracbman (1974)
10.1016/0014-2999(87)90424-9 / Eur j Pharmacol / 9-amino-1,2,3,4-tetrahydroacridine (THA), an alleged drug for the treatment of Alzheimer's disease, inhibits acetyl-cholinesterase activity and slows outward K+ current by Drukarch (1987)
10.1016/0024-3205(88)90431-6 / Life Sci / Stoof JC: Furthr analysis of the neuropharmacological profile of 9-amino-1,2,3,4-tetrahydroacridine (THA), an alleged drug for the treatment of Alzheimer's disease by Drukarch (1988)
10.1111/j.1476-5381.1972.tb07245.x / Br J Pharmacol / Anterograde amnesic effects of pethidine, hyoscine, and diazepam in adults by Dundee (1972)
{'key': '10.1016/S0193-953X(18)30318-6_bib45', 'series-title': "Alzheimer's Disease: A Report of Progress", 'first-page': '475', 'article-title': 'Pharmacologic treatment of senile dementia: Choline, L-DOPA, piracetam and choline plus piracetam', 'author': 'Ferris', 'year': '1982'} / Alzheimer's Disease: A Report of Progress / Pharmacologic treatment of senile dementia: Choline, L-DOPA, piracetam and choline plus piracetam by Ferris (1982)
Fielding S, Cornfeldt ML, Szewczak MR et al HP-029, a new drug for the treatment of Alzheimer's disease: Its pharmacologial profile Presented at the Fourth World Conference on Clinical Pharmacology and Therapeutics, Berlin (West), July 28-30, 1989
10.1016/0920-9964(88)90024-2 / Schizophr Res / Clonidine improves memory func-tion in schizophrenia independently from changes in psychosis by Fields (1988)
{'key': '10.1016/S0193-953X(18)30318-6_bib48', 'first-page': '257', 'article-title': "AF102B: Rational treatment strategy for Alzheimer's disease", 'volume': '51', 'author': 'Fisher', 'year': '1990', 'journal-title': 'Recent advances. Adv Neurol'} / Recent advances. Adv Neurol / AF102B: Rational treatment strategy for Alzheimer's disease by Fisher (1990)
10.1176/ajp.147.2.239 / Am J Psychi-atry / Treatment of Alzheimer's disease with short- and long-term oral THA and lecithin: A double-blind study by Fitten (1990)
10.1111/j.1600-0404.1989.tb04876.x / Acta Neurol Scand / Early stages of late onset Alzheimer's disease. III. Double blind treatment with choline chloride and lecithin with and without L-Dopa and L-tryptophan, alternatively placebo by Forssell (1989)
10.1056/NEJM198106113042413 / N Engl J Med / Clinical response to choline plus piracetam in senile dementia: Relation to red-cell choline levels by Friedman (1981)
{'key': '10.1016/S0193-953X(18)30318-6_bib52', 'first-page': '417', 'article-title': 'Cholinergic effects of nootropics', 'volume': '47', 'author': 'Funk', 'year': '1988', 'journal-title': 'Biomed Biochem Acta'} / Biomed Biochem Acta / Cholinergic effects of nootropics by Funk (1988)
10.1056/NEJM199005033221804 / N Engl j Med / Tetrahydroaminoacridine-lecithin combination treatment in patients with intermediate-stage Alzheimer's disease. Results of a Canadian double-blind, crossover, multicenter study by Gauthier (1990)
{'key': '10.1016/S0193-953X(18)30318-6_bib54', 'first-page': '115', 'article-title': "Vers une pharmacologie de l'activite integrative du cerveaux. Tentative du concept nootrope en psychopharmacologie", 'volume': '25', 'author': 'Giurgea', 'year': '1972', 'journal-title': 'Actual Pharmacol (Paris)'} / Actual Pharmacol (Paris) / Vers une pharmacologie de l'activite integrative du cerveaux. Tentative du concept nootrope en psychopharmacologie by Giurgea (1972)
{'key': '10.1016/S0193-953X(18)30318-6_bib55', 'first-page': '33', 'article-title': "Disturbance of the 5-hydroxytryptamine metabolism in brains from patients with Alzheimer's dementia", 'volume': '30', 'author': 'Gottfries', 'year': '1990', 'journal-title': 'J Neural Transm Suppl'} / J Neural Transm Suppl / Disturbance of the 5-hydroxytryptamine metabolism in brains from patients with Alzheimer's dementia by Gottfries (1990)
10.1016/0197-4580(83)90002-7 / Neurobiol Aging / Biochemical changes in dementia disorders of the Alzheimer type (AD/SDAT) by Gottfries (1983)
10.1016/0278-5846(86)90014-X / Prog Neuropsychopharmacol Biol Psychiatry / Multiple deficits in both gray and white matter in Alzheimer's brains by Gottfries (1986)
10.1016/0197-4580(89)90143-7 / Neurobiol Aging / Review: Excitatory amino acids and Alzheimer's disease by Greenamyre (1989)
10.1016/0197-4580(86)90007-2 / Neurobiol Aging / Piracetam combined with lecithin in the treatment of Alzheimer's disease by Growdon (1986)
10.1016/0028-3908(87)90143-2 / Neuropharmacology / A comparison of the effects of two inhibitors on brain cholinesterase by Hallak (1987)
10.1016/0006-8993(86)90179-4 / Brain Res / Partial reversal of lesion-induced deficits in cortical cholinergic markers by nerve growth factor by Haratounian (1986)
10.1016/0006-8993(90)90280-O / Brain Res / Restoration of cholinomimetic activity by clonidine in cholinergic plus adrenergic lesioned rats by Haratounian (1990)
{'key': '10.1016/S0193-953X(18)30318-6_bib63', 'first-page': '271', 'article-title': "Intracerebroventricular bethanechloride administration in Alzheimer's disease. Preliminary results of a double blind study", 'volume': '24', 'author': 'Harbaugh', 'year': '1987', 'journal-title': 'J Neurotransm'} / J Neurotransm / Intracerebroventricular bethanechloride administration in Alzheimer's disease. Preliminary results of a double blind study by Harbaugh (1987)
10.1111/j.1532-5415.1990.tb03471.x / J Am Geriatr Soc / Biological and neuropharmacological charac-terization of physostigmine responders and nonresponders in Alzheimer's dis-ease by Harrell (1990)
10.1523/JNEUROSCI.06-08-02155.1986 / J Neurosci / Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections by Hefti (1986)
10.1038/jcbfm.1988.104 / J Cereb Blood Flow Metab / Effects of piracetam on cerebral glucose metabolism in Alzheimer's disease as measured by positron emission tomography by Heiss (1988)
10.1002/ana.410250413 / Ann Neurol / Multicenter trial of naloxone in Alzheimer's disease by Henderson (1989)
10.1016/0006-3223(87)90049-7 / Biol Psychiatry / RS 86 in the treatment of Alz-heimer's disease: Cognitive and biological effects by Hollander (1987)
10.7326/0003-4819-100-6-894 / Ann Intern Med / Ergoloid mesylates for senile dementias: Unanswered questions by Hollister (1984)
10.1002/ddr.430020506 / Drug Der Res / The effects of oxiracetam (ISF 2522) in patients with organic brain syndrome (a double-blind controlled study with piracetam) by Itil (1982)
{'issue': '3', 'key': '10.1016/S0193-953X(18)30318-6_bib71', 'first-page': '670', 'article-title': 'CNS pharmacology and clinical therapeutical effects of oxiracetam', 'volume': '9', 'author': 'Itl', 'year': '1986', 'journal-title': 'Clin Neuropharmacol'} / Clin Neuropharmacol / CNS pharmacology and clinical therapeutical effects of oxiracetam by Itl (1986)
10.1016/0047-6374(80)90125-6 / Ageing Dev / Levodopa in the treatment of (pre) senile dementia by Jellinger (1980)
10.1097/00002093-199040400-00004 / Alzheimer's Dis Assoc Disord / Oral physostigmine as treatment for dementia of Alzheimer's type: A long-term outpatient trial by Jenike (1990)
10.1177/089198879000300104 / J Geriatr Psychia-try Neurol / Oral physostigmine for primary degenerative dementia: A double blind placebo-controlled inpatient trial by Jenike (1990)
{'key': '10.1016/S0193-953X(18)30318-6_bib75', 'first-page': '3', 'article-title': "Oral physostigmine treatment for patients with presenile and senile dementia of Alzheimer's type: A double blind pla-cebo-controlled trial", 'volume': '51', 'author': 'Jenike', 'year': '1990', 'journal-title': 'J Clin Psychiatry'} / J Clin Psychiatry / Oral physostigmine treatment for patients with presenile and senile dementia of Alzheimer's type: A double blind pla-cebo-controlled trial by Jenike (1990)
10.1038/341226a0 / Nature / Amyloid flprotein deposition in tissue other than brain in Alzheimer's disease by Joachim (1989)
10.1016/S0079-6123(08)64320-4 / Prog Brain Res / Neuropeptides and the treatment of cognitive deficits in aging and dementia by Jones (1986)
10.3109/00048678609161337 / Austr N Z J Psychiatry / Effects of cholinergic enhancement therapies on memory function in Alzheimer's disease: A metaanalysis of the literature by Jorm (1986)
{'key': '10.1016/S0193-953X(18)30318-6_bib78', 'series-title': 'Diagnosis and Treatment of Senile Dementia', 'first-page': '339', 'article-title': 'Therapeutic efficacy of nootropic drugs-a discussion of clinical phase III studies with nimodipine as a model', 'author': 'Kanowski', 'year': '1989'} / Diagnosis and Treatment of Senile Dementia / Therapeutic efficacy of nootropic drugs-a discussion of clinical phase III studies with nimodipine as a model by Kanowski (1989)
{'key': '10.1016/S0193-953X(18)30318-6_bib79', 'first-page': '275', 'article-title': 'Modest facilitation of memory in dementia with combined lecithin and anticholinesterase treatment', 'volume': '17', 'author': 'Kaye', 'year': '1982', 'journal-title': 'Biol Psychiatry'} / Biol Psychiatry / Modest facilitation of memory in dementia with combined lecithin and anticholinesterase treatment by Kaye (1982)
10.1038/331530a0 / Nature / Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity by Kitaguchi (1988)
10.1093/oxfordjournals.bmb.a072087 / Br Med Bull / Pharmacological treatments of dementia (non-cho-linergic) by Kopeland (1986)
10.1016/S0079-6123(08)60214-9 / Prog Brain Res / Neuropeptides and dementia by Kragh-Sorensen (1987)
10.1111/j.1600-0447.1977.tb00139.x / Acta Psychiatr Scand / Levodopa treatment of presenile dementia by Kristensen (1977)
10.1016/S0140-6736(83)92108-6 / Lancet / Early results from double blind, placebo controlled trial of high-dose phosphatidylcholine in Alzheimer's disease by Levy (1983)
10.1136/jnnp.48.8.736 / J Neurol Neurosurg Psychiatry / A double blind, placebo controlled trial of high-dose lecithin in Alzheimer's disease by Little (1985)
{'key': '10.1016/S0193-953X(18)30318-6_bib86', 'first-page': '1921', 'article-title': 'New analogs of physostigmine', 'volume': '43', 'author': 'Marta', 'year': '1988', 'journal-title': "Alternative drugs for Alzheimer's disease Life Sci"} / Alternative drugs for Alzheimer's disease Life Sci / New analogs of physostigmine by Marta (1988)
10.1055/s-2007-1017117 / Pharmacopsychiatry / Brief information on an early phase II study with deprenyl in demented patients by Martini (1987)
10.1126/science.3992249 / Science / Potter LT: Loss of M2 muscarinic receptors in the cerebral cortex in Alzheimer's disease and experimental cholinergic denervation by Mash (1985)
{'key': '10.1016/S0193-953X(18)30318-6_bib89', 'series-title': 'Psycho-pharmacology of Old Age', 'first-page': '113', 'article-title': 'Drug treatment of senile dementia', 'author': 'McDonald', 'year': '1983'} / Psycho-pharmacology of Old Age / Drug treatment of senile dementia by McDonald (1983)
10.1002/ana.410070513 / Ann Neurol / Memory enhancement in Korsakoff's psychosis by clonidine: Further evidence of a noradrenergic deficit by McEntee (1980)
10.1212/WNL.34.7.939 / Neurology / Clinical diagnosis of Alzheimer’s disease: Report of NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s disease by McKhann (1984)
10.1007/BF00451695 / Psychopharmacology / Acute effects on high-dose thyrotro-pin releasing hormone infusions in Alzheimer’s disease by Mellow (1989)
10.1159/000138571 / Pharmacology / Pharmacokinetics of galanthamine hydrobromide after single subcutaneous and oral dosage in humans by Mihailova (1989)
10.2739/kurumemedj.31.135 / Kurume Med J / Effects of aniracetam, a nootropic drug, in senile dementia-a preliminary report by Mizuki (1984)
10.1001/archneur.1989.00520400030015 / Arch Neurol / Clonidine treatment of Alzheimer’s disease by Mohr (1989)
10.1001/archpsyc.1987.01800170019003 / Arch Gen Psychia-try / Alzheimer’s disease: Morbid risk among first degree-relatives approximates 50% by 90 years by Mohs (1987)
{'key': '10.1016/S0193-953X(18)30318-6_bib97', 'series-title': 'Psychopharmacology: The Third Gen-eration of Progress', 'first-page': '921', 'article-title': 'The experimental pharmacology of Alzheimer’s disease and related dementias', 'author': 'Mohs', 'year': '1987'} / Psychopharmacology: The Third Gen-eration of Progress / The experimental pharmacology of Alzheimer’s disease and related dementias by Mohs (1987)
{'issue': '3', 'key': '10.1016/S0193-953X(18)30318-6_bib98', 'first-page': '573', 'article-title': 'Activity of oxiracetam in patients with organic brain syndrome: A neuropsychological study', 'volume': '9', 'author': 'Moglia', 'year': '1986', 'journal-title': 'Clin Neuropharmacol'} / Clin Neuropharmacol / Activity of oxiracetam in patients with organic brain syndrome: A neuropsychological study by Moglia (1986)
10.1007/BF02245795 / Psychopharmacology / TRH attenuates scopolamine-induced memory impairment in humans by Molchan (1990)
10.1007/BF02244597 / Psychopharmacology / Nootropic effects of ACE inhibitors in mice by Mondadori (1990)
10.1126/science.402696 / Science / Angiotensin injected into the neostriatum after learning disrupts retention performance by Morgan (1977)
10.1002/ana.410240105 / Ann Neurol / Validation of clinical diagnostic criteria in senile dementia of the Alzheimer type by Morris (1988)
10.1212/WNL.38.4.606 / Neurology / No response to high-dose muscarinic agonist therapy in Alzheimer’s disease by Mouradian (1988)
10.1254/jjp.48.502 / Jpn J Pharmacol / Amelioration of experimental amnesia (passive avoidance failure) in rodents by selective M1 agonist AF102B by Nakahara (1988)
10.1007/BF00174504 / Psychopharmacology / Intravenous nicotine in Alz-heimer’s disease: A pilot study by Newhouse (1988)
10.1002/ddr.430190307 / Drug Dev Res / DuP 996 (3,3-bis(4-pyridinylmethyl)-1-phenylindolin-2-one) enhances the stimulus-induced release of acetylcholine from rat brain in vitro and in vivo by Nickolson (1990)
{'key': '10.1016/S0193-953X(18)30318-6_bib107', 'series-title': 'Current Research in Alzheimer therapy', 'first-page': '281', 'article-title': 'Metrifonate: A review', 'author': 'Nordgren', 'year': '1988'} / Current Research in Alzheimer therapy / Metrifonate: A review by Nordgren (1988)
10.1016/S0026-895X(25)14382-4 / Mol Pharmacol / Presynaptic antagonist-postsynaptic agonistat muscarinic cholinergic synapses by Nordstoem (1983)
{'key': '10.1016/S0193-953X(18)30318-6_bib109', 'series-title': 'Current Research in Alzheimer Therapy', 'first-page': '231', 'article-title': 'Preliminary experiences and results with THA for the amelioration of symptoms of Alzheimer’s disease', 'author': 'Nyback', 'year': '1988'} / Current Research in Alzheimer Therapy / Preliminary experiences and results with THA for the amelioration of symptoms of Alzheimer’s disease by Nyback (1988)
{'key': '10.1016/S0193-953X(18)30318-6_bib110', 'series-title': 'Psychopharmacology: The Third Generation of Progress', 'first-page': '941', 'article-title': 'Dementia: Animal models of the cognitive impairments produced by degeneration of the basal forebrain cholinergic system', 'author': 'Olton', 'year': '1987'} / Psychopharmacology: The Third Generation of Progress / Dementia: Animal models of the cognitive impairments produced by degeneration of the basal forebrain cholinergic system by Olton (1987)
10.1016/0014-2999(88)90404-9 / Eur J Pharmacol / Heterogeneity of muscarinic heteroreceptors in the rat brain: Effects of a novel M1 agonist, AF102B by Ono (1988)
{'key': '10.1016/S0193-953X(18)30318-6_bib112', 'first-page': '2745', 'article-title': 'Gershon S', 'volume': '4', 'author': 'Palmer', 'year': '1990', 'journal-title': 'Is the neuronal basis of Alzheimer’s disease cholinergic or glutamatergic FASEB J'} / Is the neuronal basis of Alzheimer’s disease cholinergic or glutamatergic FASEB J / Gershon S by Palmer (1990)
10.1111/j.1365-2044.1970.tb00255.x / Anesthesia / Preoperative amnesia: The incidence following the intra-muscular injection of commonly used premedicants by Panditt (1970)
10.1007/BF02245803 / Psychopharmacology / Oxiracetam and D-pyroglutamic acid antagonize a disruption of passive avoidance behaviour induced by the N-methyl-D-aspartate receptor antagonist 2-amio-5-phosphonovalerate by Paoli (1990)
{'key': '10.1016/S0193-953X(18)30318-6_bib115', 'first-page': '367', 'article-title': 'Mental impairment in aging: Selection of patients, methods of evaluation and therapeutic possibilities of actyl-L-carni-tine', 'volume': '8', 'author': 'Passeri', 'year': '1988', 'journal-title': 'Int J Clin Pharmacol Res'} / Int J Clin Pharmacol Res / Mental impairment in aging: Selection of patients, methods of evaluation and therapeutic possibilities of actyl-L-carni-tine by Passeri (1988)
10.1212/WNL.38.2.219 / Neurology / Intraventricular bethanechol infusion of Alzheimer’s disease: Results of double blind and escalating dose trials by Penn (1988)
10.1055/s-2007-1014630 / Pharmacopsychiatry / The relationship between the behavioral effects of cognition-enhancing drugs and brain acetylcholine by Pepeu (1989)
10.1016/S0140-6736(77)91780-9 / Lancet / Necropsy evidence of central cholinergic deficits in senile dementia by Perry (1977)
10.1136/bmj.2.6150.1457 / BMJ / Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia by Perry (1978)
10.1097/00002826-199004000-00004 / Clin Neuropharmacol / Neuropsychological effects of L-deprenyl in Alzheimer’s type dementia by Piccinin (1990)
{'key': '10.1016/S0193-953X(18)30318-6_bib121', 'first-page': '388', 'article-title': 'Combined piracetam and cholinergic precursor treatment for primary degenerative dementia', 'volume': '12', 'author': 'Pomara', 'year': '1984', 'journal-title': 'IRCS Med Sci'} / IRCS Med Sci / Combined piracetam and cholinergic precursor treatment for primary degenerative dementia by Pomara (1984)
10.1002/j.1552-4604.1989.tb03328.x / J Clin Pharmacol / Single dose safety, tolerance, and pharmacokinetics of HP 029 in healthy young men: A potential Alzheimer’s agent by Puri (1989)
10.1185/03007999009112690 / Curr Med Res Opin / Double-blind, placebo controlled study of acetyl-L-carnitine in patients with Alzheimer’s dementia by Rai (1990)
Rainer M, Mark TH, Haushofer A: Galanthaminum hydrobromicum in treatment of senile dementia (Alzheimer’s disease). Presented at the Fourth World Conference on Clinical Pharmacology and Therapeutics, Berlin (West), July 28–30, 1989
10.1001/archneur.1990.00530090105020 / Arch Neurol / Intracerebroventricular bethanechol for Alz-heimer’s disease. Variable dose-related responses by Read (1990)
10.1016/0024-3205(87)90221-9 / Life Sci / Decreased muscarinic receptor binding in cerebral cortex and hippocampus in Alzheimer’s disease by Reinikainen (1987)
{'key': '10.1016/S0193-953X(18)30318-6_bib127', 'first-page': '45', 'article-title': 'Naloxone effects on primary degenerative dementia (PDD)', 'volume': '19', 'author': 'Reisberg', 'year': '1983', 'journal-title': 'Psychopharmacol Bull'} / Psychopharmacol Bull / Naloxone effects on primary degenerative dementia (PDD) by Reisberg (1983)
10.1056/NEJM198303243081213 / N Engl J Med / Effects of naloxone in senile dementia: A double blind trial by Reisberg (1983)
{'key': '10.1016/S0193-953X(18)30318-6_bib129', 'first-page': '348', 'article-title': 'Clinical experience with a cholinesterase inhibitor (HP 029) in the treatment of Alzheimer’s disease: Can it make a difference Abstracts from the Second International Conference on Alzheimer’s Disease and Related Disorders', 'volume': '11', 'author': 'Richter', 'year': '1990', 'journal-title': 'Neurobiol Aging'} / Neurobiol Aging / Clinical experience with a cholinesterase inhibitor (HP 029) in the treatment of Alzheimer’s disease: Can it make a difference Abstracts from the Second International Conference on Alzheimer’s Disease and Related Disorders by Richter (1990)
{'key': '10.1016/S0193-953X(18)30318-6_bib130', 'first-page': '158', 'article-title': 'Morphological and biochemical changes in the aging brain: Pathophysiological and possible therapeutic consequences', 'volume': '5', 'author': 'Riederer', 'year': '1982', 'journal-title': 'Exp Brain Res'} / Exp Brain Res / Morphological and biochemical changes in the aging brain: Pathophysiological and possible therapeutic consequences by Riederer (1982)
10.1126/science.3201248 / Science / Grafting genetically modified cells to the damaged brain: Restorative effects of NGF expression by Rosenberg (1988)
10.1093/oxfordjournals.bmb.a072101 / Br Med Bull / Non-cholinergic neurotransmitter abnormalities in Alzheimer’s disease by Rossor (1986)
10.1111/j.1365-2125.1989.tb03500.x / Br J Clin Pharmacol / EEG brain mapping in evaluating the time-course of the central action of DUP 996- a new acetylcholine releasing drug by Saletu (1989)
10.1159/000118263 / Neuropsychobiology / Some considerations of different modes of action of nootropic drugs by Sarter (1986)
10.1097/00002826-198904000-00007 / Clin Neuropharmacol / Guanfacine treatment of Alzheimer’s disease by Schlegel (1989)
{'key': '10.1016/S0193-953X(18)30318-6_bib136', 'series-title': 'Alzheimer’s Disease', 'first-page': '362', 'article-title': 'Nootropics', 'author': 'Schneck', 'year': '1983'} / Alzheimer’s Disease / Nootropics by Schneck (1983)
{'key': '10.1016/S0193-953X(18)30318-6_bib137', 'series-title': 'Diagnosis and Treatment of Senile Dementia', 'first-page': '295', 'article-title': 'Old rats as an animal model for senile dementia: Beha-vioural effects of nimodipine', 'author': 'Schuurman', 'year': '1989'} / Diagnosis and Treatment of Senile Dementia / Old rats as an animal model for senile dementia: Beha-vioural effects of nimodipine by Schuurman (1989)
10.1111/j.1532-5415.1974.tb01521.x / J Am Geriatr Soc / A new scale for clinical assessment in geriatric populations: Sandoz Clinical Assessment-Geriatric (SCAG) by Shader (1974)
10.1021/jm00402a002 / J Med Chem / (±)-9-amino-1,2,3,4,-tetrahydroa-cridin-1-ol. A potential Alzheimer’s disease therapeutic of low toxicity by Shutske (1988)
10.1126/science.351808 / Science / Human serial learning: Enhancement with arecoline and impairment with scopolamine correlated with performance on placebo by Sitaram (1978)
{'key': '10.1016/S0193-953X(18)30318-6_bib141', 'first-page': '542', 'article-title': 'Comparison of therapeutic response to long-term treatment with lecithin versus piracetam plus lecithin in patients with Alzheimer’s disease', 'volume': '20', 'author': 'Smith', 'year': '1984', 'journal-title': 'Psychopharmacol Bull'} / Psychopharmacol Bull / Comparison of therapeutic response to long-term treatment with lecithin versus piracetam plus lecithin in patients with Alzheimer’s disease by Smith (1984)
10.1126/science.2111585 / Science / Platelet coagulation factor Ma-inhibitor, a form of Alzheimer amyloid precursor protein by Smith (1990)
10.1007/BF00690933 / Psychopharmacology / Senile dementia of the Alzheimer’s type treated with aniracetam by Sourander (1987)
10.1002/ana.410220305 / Ann Neurol / Effects of oral physostigmine in Alzheimer’s disease by Stern (1987)
10.1056/NEJM198611133152001 / N Engl J Med / Oral tetrahydroaminoacridine in long-term treatment of senile dementia after Alzheimer type by Summers (1986)
10.1159/000116478 / Eur Neurol / Tacrine in the treatment of Alzheimer’s disease. A clinical update and recent pharmacological studies by Summers (1989)
{'key': '10.1016/S0193-953X(18)30318-6_bib147', 'first-page': '145', 'article-title': 'Use of THA in treatment of Alzheimer-like dementia: Pilot study in twelve patients', 'volume': '16', 'author': 'Summers', 'year': '1981', 'journal-title': 'Biol Psychiatry'} / Biol Psychiatry / Use of THA in treatment of Alzheimer-like dementia: Pilot study in twelve patients by Summers (1981)
{'key': '10.1016/S0193-953X(18)30318-6_bib148', 'first-page': '507', 'article-title': 'Effects of huperzine A on learning and retrieval process of discrimination performance in rats', 'volume': '7', 'author': 'Tang', 'year': '1986', 'journal-title': 'Acta Pharmacol Sinica'} / Acta Pharmacol Sinica / Effects of huperzine A on learning and retrieval process of discrimination performance in rats by Tang (1986)
{'key': '10.1016/S0193-953X(18)30318-6_bib149', 'series-title': 'Current Research in Alzheimer Therapy', 'first-page': '289', 'article-title': 'Studies on the nootropic effects of huperzine A and B: Two selective AChE inhibitors', 'author': 'Tang', 'year': '1988'} / Current Research in Alzheimer Therapy / Studies on the nootropic effects of huperzine A and B: Two selective AChE inhibitors by Tang (1988)
10.1001/archpsyc.1987.01800170041007 / Arch Gen Psychiatry / L-deprenyl in Alzheimer’s disease by Tariot (1987)
10.1001/archpsyc.1988.01800340023003 / Arch Gen Psychiatry / Multiple-dose arecoline infusions in Alzheimer’s disease by Tariot (1988)
10.1007/BF00216016 / Psychopharmacology / Cognitive effects of L-deprenyl in Alzheimer’s disease by Tariot (1987)
10.1111/j.1532-5415.1989.tb05682.x / J Am Geriatr Soc / The safety and lack of efficacy of vinpocetine in Alzheimer’s disease by Thal (1989)
10.1056/NEJM199008163230704 / N Engl J Med / Lack of efficacy of hydergine in patients with Alzheimer’s disease by Thompson (1990)
Thomsen T, Kewitz H: Galanthamine treatment in senile dementia of Alzheimer’s type. A case report. Presented at the Fourth World Conference on Clinical Pharmacology and Therapeutics, Berlin (West), July 28–30, 1989
10.1016/0006-3223(90)90050-C / Biol Psychiatry / Short-term effects of the calcium channel blocker nimodipine (Bay-e-9736) in the management of primary degenerative dementia by Tollefson (1990)
10.1001/archneur.1989.00520370040016 / Arch Neurol / A community based study of parental age at the birth of patients with dementia of the Alzheimer’s type by Urakami (1989)
{'issue': '14', 'key': '10.1016/S0193-953X(18)30318-6_bib158', 'first-page': '301', 'article-title': 'Clinical and neuropsychological investigations on oxiracetam in patients with mild to moderate dementia', 'volume': '9', 'author': 'Villardita', 'year': '1986', 'journal-title': 'Clin Neuropharmacol'} / Clin Neuropharmacol / Clinical and neuropsychological investigations on oxiracetam in patients with mild to moderate dementia by Villardita (1986)
Vincent GP, Rummenik L, Cumin R, et al: Effects ofhuperzine A, an acetylcholinesterase inhibitor on the enhancement of memory in mice, rats, and monkeys [abstract no. 237.4]. Presented at the Society for Neuroscience, 1987
{'key': '10.1016/S0193-953X(18)30318-6_bib160', 'first-page': '110', 'article-title': 'Anti-cholinesterase activity of huperzine A', 'volume': '7', 'author': 'Wang', 'year': '1986', 'journal-title': 'Acta Pharmacol Sinica'} / Acta Pharmacol Sinica / Anti-cholinesterase activity of huperzine A by Wang (1986)
10.1017/S0317167100027694 / Can J Neurol Sci / Cognitive enhancing agents: Current status in the treatment of Alz-heimer’s disease by Waters (1988)
10.1126/science.2157282 / Science / The calcium channel blocker nifedipine attenuates slow excitatory amino acid neurotoxicity by Weiss (1990)
10.1056/NEJM198404123101514 / N Engl J Med / Effects of 4-aminopyridine in elderly patients with Alzheimer’s disease by Wesseling (1984)
10.1007/BF00431470 / Psycho-pharmacology / Clinical studies with the cholinergic drug RS-86 in Alz-heimer’s disease (AD) and senile dementia of Alzheimer type (SDAT) by Wettstein (1984)
{'key': '10.1016/S0193-953X(18)30318-6_bib165', 'first-page': '175', 'article-title': 'Nicotinic and muscarinic cholinergic receptors in Alz-heimer’s disease and related disorders', 'volume': '24', 'author': 'Whitehouse', 'year': '1987', 'journal-title': 'J Neural Transm Suppl'} / J Neural Transm Suppl / Nicotinic and muscarinic cholinergic receptors in Alz-heimer’s disease and related disorders by Whitehouse (1987)
10.1126/science.7058341 / Science / Alzheimer’s disease and senile dementia: Loss of neurons in the basal forebrain by Whitehouse (1982)
10.1126/science.2928783 / Science / Amyloid ß protein enhances survival of hippocampal neurons in vitro by Whitson (1989)
{'key': '10.1016/S0193-953X(18)30318-6_bib168', 'first-page': '17', 'article-title': 'Behavioral and neurochemical effects of chronic intraventricular injections of nerve growth factor in adult rats with fimbria lesions', 'volume': '17', 'author': 'Will', 'year': '1985', 'journal-title': 'Brain Res'} / Brain Res / Behavioral and neurochemical effects of chronic intraventricular injections of nerve growth factor in adult rats with fimbria lesions by Will (1985)
10.1111/j.1749-6632.1988.tb31825.x / Ann NY Acad Sci / New intrathecal drugs in Alzheimer’s disease and psycho-metric testing by Wilson (1988)
10.1097/00005053-198103000-00001 / J Nerv Ment Dis / Pharmacotherapy for aged related behavioral deficiencies by Wittenborn (1981)
10.1212/WNL.40.7.1099 / Neurology / DGAVP (Org 5667) in early Alz-heimer’s disease patients: An international double-blind, placebo-controlled, multicenter trial by Wolters (1990)
10.1007/BF00167042 / Naunyn Schmiedebergs Arch Pharmacol / Cholinomimetic activities of minaprine by Worms (1989)
10.1002/ana.410170608 / Ann Neurol / Nucleus raphe dorsalis in Alzheimer’s disease: Neurofibrillary tangles and loss of large neurons by Yamamoto (1985)
10.1126/science.2218531 / Science / Neurotrophic and neurotoxic effects of amyloid fl protein: Reversal by tachykininneuropeptides by Yankner (1990)
{'key': '10.1016/S0193-953X(18)30318-6_bib175', 'first-page': '260', 'article-title': 'Therapeutic effects of huperzine A on the aged with memory impair-ment', 'volume': '5', 'author': 'Zhang', 'year': '1986', 'journal-title': 'New Drugs Clin Remedies'} / New Drugs Clin Remedies / Therapeutic effects of huperzine A on the aged with memory impair-ment by Zhang (1986)

Dates

Type	When
Created	7 years, 2 months ago (June 18, 2018, 6:56 a.m.)
Deposited	2 months ago (July 5, 2025, 12:53 a.m.)
Indexed	2 months ago (July 6, 2025, 12:01 a.m.)
Issued	34 years, 3 months ago (June 1, 1991)
Published	34 years, 3 months ago (June 1, 1991)
Published Print	34 years, 3 months ago (June 1, 1991)

Funders 0

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BibTeX

@article{Davidson_1991, title={The Treatment of Cognitive Impairment in Alzheimer’s Disease: Beyond the Cholinergic Approach}, volume={14}, ISSN={0193-953X}, url={http://dx.doi.org/10.1016/s0193-953x(18)30318-6}, DOI={10.1016/s0193-953x(18)30318-6}, number={2}, journal={Psychiatric Clinics of North America}, publisher={Elsevier BV}, author={Davidson, Michael and Stem, Robert G.}, year={1991}, month=jun, pages={461–482} }

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      "first-page": "4287",
      "DOI": "10.1523/JNEUROSCI.08-11-04287.1988",
      "article-title": "Goldman-Rakic PS: The alpha-2 adrenergic agonist guanfa-eine improves memory in aged monkeys without sedative or hypotensive side effects: Evidence for alpha-2 receptor subtypes",
      "volume": "8",
      "author": "Arnstein",
      "year": "1988",
      "journal-title": "J Neurosci"
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      "first-page": "1490",
      "DOI": "10.1111/j.1471-4159.1982.tb07930.x",
      "article-title": "Angiotensin converting enzyme in Alz-heimer's disease: Increased activity in caudate nucleus and cortical areas",
      "volume": "38",
      "author": "Arregui",
      "year": "1982",
      "journal-title": "J Neurochem"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib3",
      "series-title": "Treatment Development Strategies for Alzheimer's disease, Madison, Connecticut, Mark Powley Associates",
      "first-page": "584",
      "article-title": "Alzheimer's disease: Strategies for treatment and research",
      "author": "Bagne",
      "year": "1986"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib4",
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      "first-page": "408",
      "DOI": "10.1126/science.7046051",
      "article-title": "The cholinergic hypothesis of geriatric memory dysfunction",
      "volume": "217",
      "author": "Bartus",
      "year": "1982",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib5",
      "series-title": "Psychopharmacology: The Third Generation of Progress",
      "first-page": "219",
      "article-title": "Cholinergic psychopharmacology: An integration of human and animal research on memory",
      "author": "Bartus",
      "year": "1987"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib6",
      "doi-asserted-by": "crossref",
      "first-page": "332",
      "DOI": "10.1111/j.1749-6632.1985.tb37600.x",
      "article-title": "The cholinergic hypothesis: A histori-cal overview, current perspective and future directions",
      "volume": "444",
      "author": "Bartus",
      "year": "1985",
      "journal-title": "Ann NY Acad Sci"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib7",
      "doi-asserted-by": "crossref",
      "first-page": "19",
      "DOI": "10.1111/j.1600-0404.1988.tb07983.x",
      "article-title": "Potential pharmacotherapy of Alzheimer's disease",
      "volume": "116",
      "author": "Becker",
      "year": "1988",
      "journal-title": "A comparison of various routes of administration. Acta Neurol Scand Suppl"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib8",
      "first-page": "400",
      "article-title": "Long-term outpatient treatment of senile dementia with oral physostigmine",
      "volume": "49",
      "author": "Beller",
      "year": "1988",
      "journal-title": "J Clin Psychiatry"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib9",
      "doi-asserted-by": "crossref",
      "first-page": "279",
      "DOI": "10.1007/BF00436170",
      "article-title": "Alaproclate: A pharmacokinetic and biochemical study in patients with dementia of Alzheimer's type",
      "volume": "80",
      "author": "Bergmann",
      "year": "1983",
      "journal-title": "Psychopharm-acology"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib10",
      "doi-asserted-by": "crossref",
      "first-page": "76",
      "DOI": "10.1212/WNL.39.1.76",
      "article-title": "Diagnosis of dementia: Clinicopathological correla-tions",
      "volume": "29",
      "author": "Boller",
      "year": "1989",
      "journal-title": "Neurology"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib11",
      "doi-asserted-by": "crossref",
      "first-page": "164",
      "DOI": "10.1212/WNL.32.2.164",
      "article-title": "Loss of neurons of origin of the adrenergic projection to cerebral cortex (nucleus locus coeruleus) in senile dementia",
      "volume": "32",
      "author": "Bondareff",
      "year": "1982",
      "journal-title": "Neurology"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib12",
      "doi-asserted-by": "crossref",
      "first-page": "148",
      "DOI": "10.1016/0166-2236(89)90054-4",
      "article-title": "The molecular basis of muscarinic receptor diversity",
      "volume": "12",
      "author": "Bonner",
      "year": "1989",
      "journal-title": "Trends Neurosci"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib13",
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      "first-page": "527",
      "DOI": "10.1126/science.3037705",
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      "volume": "237",
      "author": "Bonner",
      "year": "1987",
      "journal-title": "Science"
    },
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      "key": "10.1016/S0193-953X(18)30318-6_bib14",
      "series-title": "Nimodipine: Pharmacological and Clinical Studies. Stuttgart, Schattauer",
      "first-page": "275",
      "article-title": "Nimodipine in cCVD patients, clinical and neuropsychological results of a double-blind crossover study",
      "author": "Bono",
      "year": "1985"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib15",
      "first-page": "266",
      "article-title": "Biochemical assessment of serotonergic and cholinergic dysfunction and cerebral atrophy in Alzheimer's disease",
      "volume": "41",
      "author": "Bowen",
      "year": "1983",
      "journal-title": "J Neuro-chem"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib16",
      "first-page": "212",
      "article-title": "The efficacy of the cerebral metabolic enhancers in the treatment of senile dementia",
      "volume": "19",
      "author": "Branconnier",
      "year": "1983",
      "journal-title": "Psychopharmacol Bull"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib17",
      "first-page": "726",
      "article-title": "The therapeutic efficacy of piracetam in Alzheimer's disease: Preliminary observations",
      "volume": "19",
      "author": "Branconnier",
      "year": "1983",
      "journal-title": "Psychopharmacol Bull"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib18",
      "doi-asserted-by": "crossref",
      "first-page": "66A",
      "DOI": "10.1016/0006-3223(89)91620-X",
      "article-title": "Murphy EA: Risk factor intervention in Alz-heimer's disease: Delay of onset by five years will halve morbidity [abstr]",
      "volume": "7A",
      "author": "Breitner",
      "year": "1989",
      "journal-title": "Biol Psychiatry"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib19",
      "doi-asserted-by": "crossref",
      "first-page": "89",
      "DOI": "10.1016/S0197-4580(89)80015-6",
      "article-title": "Production and characterization of biologically active recombinant human nerve growth factor",
      "volume": "10",
      "author": "Bruce",
      "year": "1989",
      "journal-title": "Neurobiol Aging"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib20",
      "doi-asserted-by": "crossref",
      "first-page": "115",
      "DOI": "10.1111/j.1432-1033.1986.tb09646.x",
      "article-title": "Anticholinesterase activity of a new carbamate, heptylphysostigmine, in view of its use in patients with Alzheimer-type dementia",
      "volume": "157",
      "author": "Brufani",
      "year": "1986",
      "journal-title": "Eur J Biochem"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "659",
      "DOI": "10.1001/archneur.1986.00520070017009",
      "article-title": "RS-86 therapy of Alzheimer's disease",
      "volume": "43",
      "author": "Bruno",
      "year": "1985",
      "journal-title": "Arch Neurol"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "469",
      "DOI": "10.1016/S0026-895X(25)11261-3",
      "article-title": "Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells",
      "volume": "35",
      "author": "Buckley",
      "year": "1989",
      "journal-title": "Mol Pharmacol"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib23",
      "doi-asserted-by": "crossref",
      "first-page": "6003",
      "DOI": "10.1073/pnas.87.15.6003",
      "article-title": "Processing of Alzheimer \u00df/1/A4 amyloid precursor protein: Modulation by agents that regulate protein phosphorylation",
      "volume": "87",
      "author": "Buxbaum",
      "year": "1990",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "495",
      "DOI": "10.1136/bmj.300.6723.495",
      "article-title": "Tacrine Retrahydroaminoacridine(THA) and lecithin in senile dementia of the Alzheimer type: A multicentre trial",
      "volume": "300",
      "author": "Chatellier",
      "year": "1990",
      "journal-title": "BMJ"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "46",
      "DOI": "10.1192/bjp.138.1.46",
      "article-title": "Physostigmine and arecoline: Effects of intravenous infusions in Alzheimer's presenile dementia",
      "volume": "138",
      "author": "Christie",
      "year": "1981",
      "journal-title": "Br J Psychiatry"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1016/0306-4522(86)90002-3",
      "article-title": "Cholinergic function and intellectual decline in Alzheimer's disease",
      "volume": "19",
      "author": "Collerton",
      "year": "1986",
      "journal-title": "Neuroscience"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "301",
      "DOI": "10.1002/ddr.430190308",
      "article-title": "Cognition enhancement by the acetylcholine releaser DuP 996",
      "volume": "19",
      "author": "Cook",
      "year": "1990",
      "journal-title": "Drug Dev Res"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "211",
      "DOI": "10.1055/s-2007-1014678",
      "article-title": "Herrmann VVM: Psychostimulants, analeptics, nootropics: An attempt to differentiate and assess drugs designed for the treatment of impaired brain functions",
      "volume": "21",
      "author": "Coper",
      "year": "1988",
      "journal-title": "Pharmacopsychiatry"
    },
    {
      "issue": "1",
      "key": "10.1016/S0193-953X(18)30318-6_bib29",
      "first-page": "47",
      "article-title": "Work performance, absenteeism and antihypertensive medications",
      "volume": "5",
      "author": "Croog",
      "year": "1987",
      "journal-title": "J Hypertens"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "251",
      "DOI": "10.1007/BF00426708",
      "article-title": "The effect of methylphenidate on test performance in the cognitively impaired aged",
      "volume": "52",
      "author": "Crook",
      "year": "1977",
      "journal-title": "Psychopharmacology"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "3",
      "DOI": "10.1016/0197-4580(86)90019-9",
      "article-title": "The selectivity of the reduction of serotonin S2 receptors in Alzheimertype dementia",
      "volume": "7",
      "author": "Cross",
      "year": "1986",
      "journal-title": "Neurobiol Aging"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib31a",
      "doi-asserted-by": "crossref",
      "first-page": "744",
      "DOI": "10.1001/archneur.1985.04210090008003",
      "article-title": "Evaluation of zimelidine in Alzheimer's disease: Cognitive and biochemical measures",
      "volume": "42",
      "author": "Cutler",
      "year": "1985",
      "journal-title": "Arch Neurol"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib31b",
      "doi-asserted-by": "crossref",
      "first-page": "725",
      "DOI": "10.1056/NEJM198503143121113",
      "article-title": "Evaluation of an analog of somatostatin (L363, 586) in Alzheimer's disease",
      "volume": "312",
      "author": "Cutler",
      "year": "1985",
      "journal-title": "New Engl J Med"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib32",
      "unstructured": "Dal-Bianco P, et al: AD -Therapie durch Cholinesterasehemmung. Presented at the 19th Central European Neurobiol Symposium -CNS, Vienna, June 29-July 1st, 1989"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib33",
      "first-page": "1",
      "article-title": "Combined administration of physostig-mine and clonidine to patients with dementia of the Alzheimer type: A pilot safety study",
      "volume": "1",
      "author": "Davidson",
      "year": "1989",
      "journal-title": "Alzheimer Dis Assoc Disord"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "112",
      "DOI": "10.1016/0006-3223(87)90139-9",
      "article-title": "Lecithin and piracetam in patients with Alzheimer's disease",
      "volume": "22",
      "author": "Davidson",
      "year": "1987",
      "journal-title": "Biol Psychiatry"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib35",
      "doi-asserted-by": "crossref",
      "first-page": "485",
      "DOI": "10.1016/0006-3223(88)90020-0",
      "article-title": "4-Aminopyridine in the treatment of Alzheimer's disease",
      "volume": "23",
      "author": "Davidson",
      "year": "1988",
      "journal-title": "Biol Psychiatry"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib36",
      "doi-asserted-by": "crossref",
      "first-page": "1403",
      "DOI": "10.1016/S0140-6736(76)91936-X",
      "article-title": "Selective loss of central cholinergic neurons in Alzheimer's disease",
      "volume": "2",
      "author": "Davies",
      "year": "1976",
      "journal-title": "Lancet"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib37",
      "doi-asserted-by": "crossref",
      "first-page": "468",
      "DOI": "10.1176/ajp.144.4.468",
      "article-title": "Induction of depression with oxotre-morine in Alzheimer's disease patients",
      "volume": "144",
      "author": "Davis",
      "year": "1987",
      "journal-title": "Am J Psychiatry"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib38",
      "doi-asserted-by": "crossref",
      "first-page": "190",
      "DOI": "10.1111/j.1600-0447.1985.tb01270.x",
      "article-title": "A double-blind comparison of alaproclate and placebo in the treatment of patients with senile dementia",
      "volume": "71",
      "author": "Dehlin",
      "year": "1985",
      "journal-title": "Acta Psychiatr Scand"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib39",
      "doi-asserted-by": "crossref",
      "first-page": "62",
      "DOI": "10.1016/S0166-2236(84)80157-5",
      "article-title": "The importance of vasopressin in memory",
      "volume": "7",
      "author": "De Wied",
      "year": "1984",
      "journal-title": "Trends Neurosci"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib40",
      "doi-asserted-by": "crossref",
      "first-page": "809",
      "DOI": "10.1126/science.2916127",
      "article-title": "Nimodipine facilitates associative learning in aging rabbits",
      "volume": "243",
      "author": "Deyo",
      "year": "1989",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib41",
      "doi-asserted-by": "crossref",
      "first-page": "113",
      "DOI": "10.1001/archneur.1974.00490320001001",
      "article-title": "Human memory and the cholinergic system",
      "volume": "30",
      "author": "Dracbman",
      "year": "1974",
      "journal-title": "Arch Neurol"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib42",
      "doi-asserted-by": "crossref",
      "first-page": "153",
      "DOI": "10.1016/0014-2999(87)90424-9",
      "article-title": "9-amino-1,2,3,4-tetrahydroacridine (THA), an alleged drug for the treatment of Alzheimer's disease, inhibits acetyl-cholinesterase activity and slows outward K+ current",
      "volume": "141",
      "author": "Drukarch",
      "year": "1987",
      "journal-title": "Eur j Pharmacol"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib43",
      "doi-asserted-by": "crossref",
      "first-page": "1011",
      "DOI": "10.1016/0024-3205(88)90431-6",
      "article-title": "Stoof JC: Furthr analysis of the neuropharmacological profile of 9-amino-1,2,3,4-tetrahydroacridine (THA), an alleged drug for the treatment of Alzheimer's disease",
      "volume": "42",
      "author": "Drukarch",
      "year": "1988",
      "journal-title": "Life Sci"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib44",
      "doi-asserted-by": "crossref",
      "first-page": "140",
      "DOI": "10.1111/j.1476-5381.1972.tb07245.x",
      "article-title": "Anterograde amnesic effects of pethidine, hyoscine, and diazepam in adults",
      "volume": "44",
      "author": "Dundee",
      "year": "1972",
      "journal-title": "Br J Pharmacol"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib45",
      "series-title": "Alzheimer's Disease: A Report of Progress",
      "first-page": "475",
      "article-title": "Pharmacologic treatment of senile dementia: Choline, L-DOPA, piracetam and choline plus piracetam",
      "author": "Ferris",
      "year": "1982"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib46",
      "unstructured": "Fielding S, Cornfeldt ML, Szewczak MR et al HP-029, a new drug for the treatment of Alzheimer's disease: Its pharmacologial profile Presented at the Fourth World Conference on Clinical Pharmacology and Therapeutics, Berlin (West), July 28-30, 1989"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib47",
      "doi-asserted-by": "crossref",
      "first-page": "417",
      "DOI": "10.1016/0920-9964(88)90024-2",
      "article-title": "Clonidine improves memory func-tion in schizophrenia independently from changes in psychosis",
      "volume": "1",
      "author": "Fields",
      "year": "1988",
      "journal-title": "Schizophr Res"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib48",
      "first-page": "257",
      "article-title": "AF102B: Rational treatment strategy for Alzheimer's disease",
      "volume": "51",
      "author": "Fisher",
      "year": "1990",
      "journal-title": "Recent advances. Adv Neurol"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib49",
      "doi-asserted-by": "crossref",
      "first-page": "239",
      "DOI": "10.1176/ajp.147.2.239",
      "article-title": "Treatment of Alzheimer's disease with short- and long-term oral THA and lecithin: A double-blind study",
      "volume": "147",
      "author": "Fitten",
      "year": "1990",
      "journal-title": "Am J Psychi-atry"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib50",
      "doi-asserted-by": "crossref",
      "first-page": "43",
      "DOI": "10.1111/j.1600-0404.1989.tb04876.x",
      "article-title": "Early stages of late onset Alzheimer's disease. III. Double blind treatment with choline chloride and lecithin with and without L-Dopa and L-tryptophan, alternatively placebo",
      "volume": "121",
      "author": "Forssell",
      "year": "1989",
      "journal-title": "Acta Neurol Scand"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib51",
      "doi-asserted-by": "crossref",
      "first-page": "1490",
      "DOI": "10.1056/NEJM198106113042413",
      "article-title": "Clinical response to choline plus piracetam in senile dementia: Relation to red-cell choline levels",
      "volume": "304",
      "author": "Friedman",
      "year": "1981",
      "journal-title": "N Engl J Med"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib52",
      "first-page": "417",
      "article-title": "Cholinergic effects of nootropics",
      "volume": "47",
      "author": "Funk",
      "year": "1988",
      "journal-title": "Biomed Biochem Acta"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib53",
      "doi-asserted-by": "crossref",
      "first-page": "1272",
      "DOI": "10.1056/NEJM199005033221804",
      "article-title": "Tetrahydroaminoacridine-lecithin combination treatment in patients with intermediate-stage Alzheimer's disease. Results of a Canadian double-blind, crossover, multicenter study",
      "volume": "322",
      "author": "Gauthier",
      "year": "1990",
      "journal-title": "N Engl j Med"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib54",
      "first-page": "115",
      "article-title": "Vers une pharmacologie de l'activite integrative du cerveaux. Tentative du concept nootrope en psychopharmacologie",
      "volume": "25",
      "author": "Giurgea",
      "year": "1972",
      "journal-title": "Actual Pharmacol (Paris)"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib55",
      "first-page": "33",
      "article-title": "Disturbance of the 5-hydroxytryptamine metabolism in brains from patients with Alzheimer's dementia",
      "volume": "30",
      "author": "Gottfries",
      "year": "1990",
      "journal-title": "J Neural Transm Suppl"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib56",
      "doi-asserted-by": "crossref",
      "first-page": "261",
      "DOI": "10.1016/0197-4580(83)90002-7",
      "article-title": "Biochemical changes in dementia disorders of the Alzheimer type (AD/SDAT)",
      "volume": "4",
      "author": "Gottfries",
      "year": "1983",
      "journal-title": "Neurobiol Aging"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib57",
      "doi-asserted-by": "crossref",
      "first-page": "405",
      "DOI": "10.1016/0278-5846(86)90014-X",
      "article-title": "Multiple deficits in both gray and white matter in Alzheimer's brains",
      "volume": "10",
      "author": "Gottfries",
      "year": "1986",
      "journal-title": "Prog Neuropsychopharmacol Biol Psychiatry"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib58",
      "doi-asserted-by": "crossref",
      "first-page": "593",
      "DOI": "10.1016/0197-4580(89)90143-7",
      "article-title": "Review: Excitatory amino acids and Alzheimer's disease",
      "volume": "10",
      "author": "Greenamyre",
      "year": "1989",
      "journal-title": "Neurobiol Aging"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib59",
      "doi-asserted-by": "crossref",
      "first-page": "269",
      "DOI": "10.1016/0197-4580(86)90007-2",
      "article-title": "Piracetam combined with lecithin in the treatment of Alzheimer's disease",
      "volume": "7",
      "author": "Growdon",
      "year": "1986",
      "journal-title": "Neurobiol Aging"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib60",
      "doi-asserted-by": "crossref",
      "first-page": "521",
      "DOI": "10.1016/0028-3908(87)90143-2",
      "article-title": "A comparison of the effects of two inhibitors on brain cholinesterase",
      "volume": "26",
      "author": "Hallak",
      "year": "1987",
      "journal-title": "Neuropharmacology"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib61",
      "doi-asserted-by": "crossref",
      "first-page": "397",
      "DOI": "10.1016/0006-8993(86)90179-4",
      "article-title": "Partial reversal of lesion-induced deficits in cortical cholinergic markers by nerve growth factor",
      "volume": "386",
      "author": "Haratounian",
      "year": "1986",
      "journal-title": "Brain Res"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib62",
      "doi-asserted-by": "crossref",
      "first-page": "261",
      "DOI": "10.1016/0006-8993(90)90280-O",
      "article-title": "Restoration of cholinomimetic activity by clonidine in cholinergic plus adrenergic lesioned rats",
      "volume": "507",
      "author": "Haratounian",
      "year": "1990",
      "journal-title": "Brain Res"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib63",
      "first-page": "271",
      "article-title": "Intracerebroventricular bethanechloride administration in Alzheimer's disease. Preliminary results of a double blind study",
      "volume": "24",
      "author": "Harbaugh",
      "year": "1987",
      "journal-title": "J Neurotransm"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib64",
      "doi-asserted-by": "crossref",
      "first-page": "113",
      "DOI": "10.1111/j.1532-5415.1990.tb03471.x",
      "article-title": "Biological and neuropharmacological charac-terization of physostigmine responders and nonresponders in Alzheimer's dis-ease",
      "volume": "38",
      "author": "Harrell",
      "year": "1990",
      "journal-title": "J Am Geriatr Soc"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib65",
      "doi-asserted-by": "crossref",
      "first-page": "2155",
      "DOI": "10.1523/JNEUROSCI.06-08-02155.1986",
      "article-title": "Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections",
      "volume": "6",
      "author": "Hefti",
      "year": "1986",
      "journal-title": "J Neurosci"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib66",
      "doi-asserted-by": "crossref",
      "first-page": "613",
      "DOI": "10.1038/jcbfm.1988.104",
      "article-title": "Effects of piracetam on cerebral glucose metabolism in Alzheimer's disease as measured by positron emission tomography",
      "volume": "8",
      "author": "Heiss",
      "year": "1988",
      "journal-title": "J Cereb Blood Flow Metab"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib67",
      "doi-asserted-by": "crossref",
      "first-page": "404",
      "DOI": "10.1002/ana.410250413",
      "article-title": "Multicenter trial of naloxone in Alzheimer's disease",
      "volume": "25",
      "author": "Henderson",
      "year": "1989",
      "journal-title": "Ann Neurol"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib68",
      "doi-asserted-by": "crossref",
      "first-page": "1067",
      "DOI": "10.1016/0006-3223(87)90049-7",
      "article-title": "RS 86 in the treatment of Alz-heimer's disease: Cognitive and biological effects",
      "volume": "22",
      "author": "Hollander",
      "year": "1987",
      "journal-title": "Biol Psychiatry"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib69",
      "doi-asserted-by": "crossref",
      "first-page": "894",
      "DOI": "10.7326/0003-4819-100-6-894",
      "article-title": "Ergoloid mesylates for senile dementias: Unanswered questions",
      "volume": "100",
      "author": "Hollister",
      "year": "1984",
      "journal-title": "Ann Intern Med"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib70",
      "doi-asserted-by": "crossref",
      "first-page": "447",
      "DOI": "10.1002/ddr.430020506",
      "article-title": "The effects of oxiracetam (ISF 2522) in patients with organic brain syndrome (a double-blind controlled study with piracetam)",
      "volume": "2",
      "author": "Itil",
      "year": "1982",
      "journal-title": "Drug Der Res"
    },
    {
      "issue": "3",
      "key": "10.1016/S0193-953X(18)30318-6_bib71",
      "first-page": "670",
      "article-title": "CNS pharmacology and clinical therapeutical effects of oxiracetam",
      "volume": "9",
      "author": "Itl",
      "year": "1986",
      "journal-title": "Clin Neuropharmacol"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib72",
      "doi-asserted-by": "crossref",
      "first-page": "253",
      "DOI": "10.1016/0047-6374(80)90125-6",
      "article-title": "Levodopa in the treatment of (pre) senile dementia",
      "volume": "14",
      "author": "Jellinger",
      "year": "1980",
      "journal-title": "Ageing Dev"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib73",
      "doi-asserted-by": "crossref",
      "first-page": "226",
      "DOI": "10.1097/00002093-199040400-00004",
      "article-title": "Oral physostigmine as treatment for dementia of Alzheimer's type: A long-term outpatient trial",
      "volume": "4",
      "author": "Jenike",
      "year": "1990",
      "journal-title": "Alzheimer's Dis Assoc Disord"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib74",
      "doi-asserted-by": "crossref",
      "first-page": "13",
      "DOI": "10.1177/089198879000300104",
      "article-title": "Oral physostigmine for primary degenerative dementia: A double blind placebo-controlled inpatient trial",
      "volume": "3",
      "author": "Jenike",
      "year": "1990",
      "journal-title": "J Geriatr Psychia-try Neurol"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib75",
      "first-page": "3",
      "article-title": "Oral physostigmine treatment for patients with presenile and senile dementia of Alzheimer's type: A double blind pla-cebo-controlled trial",
      "volume": "51",
      "author": "Jenike",
      "year": "1990",
      "journal-title": "J Clin Psychiatry"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib75a",
      "doi-asserted-by": "crossref",
      "first-page": "226",
      "DOI": "10.1038/341226a0",
      "article-title": "Amyloid flprotein deposition in tissue other than brain in Alzheimer's disease",
      "volume": "341",
      "author": "Joachim",
      "year": "1989",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib76",
      "doi-asserted-by": "crossref",
      "first-page": "429",
      "DOI": "10.1016/S0079-6123(08)64320-4",
      "article-title": "Neuropeptides and the treatment of cognitive deficits in aging and dementia",
      "volume": "70",
      "author": "Jones",
      "year": "1986",
      "journal-title": "Prog Brain Res"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib77",
      "doi-asserted-by": "crossref",
      "first-page": "237",
      "DOI": "10.3109/00048678609161337",
      "article-title": "Effects of cholinergic enhancement therapies on memory function in Alzheimer's disease: A metaanalysis of the literature",
      "volume": "20",
      "author": "Jorm",
      "year": "1986",
      "journal-title": "Austr N Z J Psychiatry"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib78",
      "series-title": "Diagnosis and Treatment of Senile Dementia",
      "first-page": "339",
      "article-title": "Therapeutic efficacy of nootropic drugs-a discussion of clinical phase III studies with nimodipine as a model",
      "author": "Kanowski",
      "year": "1989"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib79",
      "first-page": "275",
      "article-title": "Modest facilitation of memory in dementia with combined lecithin and anticholinesterase treatment",
      "volume": "17",
      "author": "Kaye",
      "year": "1982",
      "journal-title": "Biol Psychiatry"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib80",
      "doi-asserted-by": "crossref",
      "first-page": "530",
      "DOI": "10.1038/331530a0",
      "article-title": "Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity",
      "volume": "331",
      "author": "Kitaguchi",
      "year": "1988",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib81",
      "doi-asserted-by": "crossref",
      "first-page": "101",
      "DOI": "10.1093/oxfordjournals.bmb.a072087",
      "article-title": "Pharmacological treatments of dementia (non-cho-linergic)",
      "volume": "42",
      "author": "Kopeland",
      "year": "1986",
      "journal-title": "Br Med Bull"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib82",
      "doi-asserted-by": "crossref",
      "first-page": "269",
      "DOI": "10.1016/S0079-6123(08)60214-9",
      "article-title": "Neuropeptides and dementia",
      "volume": "72",
      "author": "Kragh-Sorensen",
      "year": "1987",
      "journal-title": "Prog Brain Res"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib83",
      "doi-asserted-by": "crossref",
      "first-page": "41",
      "DOI": "10.1111/j.1600-0447.1977.tb00139.x",
      "article-title": "Levodopa treatment of presenile dementia",
      "volume": "55",
      "author": "Kristensen",
      "year": "1977",
      "journal-title": "Acta Psychiatr Scand"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib84",
      "doi-asserted-by": "crossref",
      "first-page": "987",
      "DOI": "10.1016/S0140-6736(83)92108-6",
      "article-title": "Early results from double blind, placebo controlled trial of high-dose phosphatidylcholine in Alzheimer's disease",
      "volume": "1",
      "author": "Levy",
      "year": "1983",
      "journal-title": "Lancet"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib85",
      "doi-asserted-by": "crossref",
      "first-page": "736",
      "DOI": "10.1136/jnnp.48.8.736",
      "article-title": "A double blind, placebo controlled trial of high-dose lecithin in Alzheimer's disease",
      "volume": "48",
      "author": "Little",
      "year": "1985",
      "journal-title": "J Neurol Neurosurg Psychiatry"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib86",
      "first-page": "1921",
      "article-title": "New analogs of physostigmine",
      "volume": "43",
      "author": "Marta",
      "year": "1988",
      "journal-title": "Alternative drugs for Alzheimer's disease Life Sci"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib87",
      "doi-asserted-by": "crossref",
      "first-page": "256",
      "DOI": "10.1055/s-2007-1017117",
      "article-title": "Brief information on an early phase II study with deprenyl in demented patients",
      "volume": "20",
      "author": "Martini",
      "year": "1987",
      "journal-title": "Pharmacopsychiatry"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib88",
      "doi-asserted-by": "crossref",
      "first-page": "1115",
      "DOI": "10.1126/science.3992249",
      "article-title": "Potter LT: Loss of M2 muscarinic receptors in the cerebral cortex in Alzheimer's disease and experimental cholinergic denervation",
      "volume": "228",
      "author": "Mash",
      "year": "1985",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib89",
      "series-title": "Psycho-pharmacology of Old Age",
      "first-page": "113",
      "article-title": "Drug treatment of senile dementia",
      "author": "McDonald",
      "year": "1983"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib90",
      "doi-asserted-by": "crossref",
      "first-page": "466",
      "DOI": "10.1002/ana.410070513",
      "article-title": "Memory enhancement in Korsakoff's psychosis by clonidine: Further evidence of a noradrenergic deficit",
      "volume": "27",
      "author": "McEntee",
      "year": "1980",
      "journal-title": "Ann Neurol"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib91",
      "doi-asserted-by": "crossref",
      "first-page": "939",
      "DOI": "10.1212/WNL.34.7.939",
      "article-title": "Clinical diagnosis of Alzheimer\u2019s disease: Report of NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer\u2019s disease",
      "volume": "34",
      "author": "McKhann",
      "year": "1984",
      "journal-title": "Neurology"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib92",
      "doi-asserted-by": "crossref",
      "first-page": "403",
      "DOI": "10.1007/BF00451695",
      "article-title": "Acute effects on high-dose thyrotro-pin releasing hormone infusions in Alzheimer\u2019s disease",
      "volume": "98",
      "author": "Mellow",
      "year": "1989",
      "journal-title": "Psychopharmacology"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib93",
      "doi-asserted-by": "crossref",
      "first-page": "50",
      "DOI": "10.1159/000138571",
      "article-title": "Pharmacokinetics of galanthamine hydrobromide after single subcutaneous and oral dosage in humans",
      "volume": "39",
      "author": "Mihailova",
      "year": "1989",
      "journal-title": "Pharmacology"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib94",
      "doi-asserted-by": "crossref",
      "first-page": "135",
      "DOI": "10.2739/kurumemedj.31.135",
      "article-title": "Effects of aniracetam, a nootropic drug, in senile dementia-a preliminary report",
      "volume": "31",
      "author": "Mizuki",
      "year": "1984",
      "journal-title": "Kurume Med J"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib95",
      "doi-asserted-by": "crossref",
      "first-page": "376",
      "DOI": "10.1001/archneur.1989.00520400030015",
      "article-title": "Clonidine treatment of Alzheimer\u2019s disease",
      "volume": "46",
      "author": "Mohr",
      "year": "1989",
      "journal-title": "Arch Neurol"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib96",
      "doi-asserted-by": "crossref",
      "first-page": "405",
      "DOI": "10.1001/archpsyc.1987.01800170019003",
      "article-title": "Alzheimer\u2019s disease: Morbid risk among first degree-relatives approximates 50% by 90 years",
      "volume": "44",
      "author": "Mohs",
      "year": "1987",
      "journal-title": "Arch Gen Psychia-try"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib97",
      "series-title": "Psychopharmacology: The Third Gen-eration of Progress",
      "first-page": "921",
      "article-title": "The experimental pharmacology of Alzheimer\u2019s disease and related dementias",
      "author": "Mohs",
      "year": "1987"
    },
    {
      "issue": "3",
      "key": "10.1016/S0193-953X(18)30318-6_bib98",
      "first-page": "573",
      "article-title": "Activity of oxiracetam in patients with organic brain syndrome: A neuropsychological study",
      "volume": "9",
      "author": "Moglia",
      "year": "1986",
      "journal-title": "Clin Neuropharmacol"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib99",
      "doi-asserted-by": "crossref",
      "first-page": "84",
      "DOI": "10.1007/BF02245795",
      "article-title": "TRH attenuates scopolamine-induced memory impairment in humans",
      "volume": "100",
      "author": "Molchan",
      "year": "1990",
      "journal-title": "Psychopharmacology"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib100",
      "doi-asserted-by": "crossref",
      "first-page": "301",
      "DOI": "10.1007/BF02244597",
      "article-title": "Nootropic effects of ACE inhibitors in mice",
      "volume": "100",
      "author": "Mondadori",
      "year": "1990",
      "journal-title": "Psychopharmacology"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib101",
      "doi-asserted-by": "crossref",
      "first-page": "87",
      "DOI": "10.1126/science.402696",
      "article-title": "Angiotensin injected into the neostriatum after learning disrupts retention performance",
      "volume": "196",
      "author": "Morgan",
      "year": "1977",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib102",
      "doi-asserted-by": "crossref",
      "first-page": "17",
      "DOI": "10.1002/ana.410240105",
      "article-title": "Validation of clinical diagnostic criteria in senile dementia of the Alzheimer type",
      "volume": "24",
      "author": "Morris",
      "year": "1988",
      "journal-title": "Ann Neurol"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib103",
      "doi-asserted-by": "crossref",
      "first-page": "606",
      "DOI": "10.1212/WNL.38.4.606",
      "article-title": "No response to high-dose muscarinic agonist therapy in Alzheimer\u2019s disease",
      "volume": "38",
      "author": "Mouradian",
      "year": "1988",
      "journal-title": "Neurology"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib104",
      "doi-asserted-by": "crossref",
      "first-page": "502",
      "DOI": "10.1254/jjp.48.502",
      "article-title": "Amelioration of experimental amnesia (passive avoidance failure) in rodents by selective M1 agonist AF102B",
      "volume": "48",
      "author": "Nakahara",
      "year": "1988",
      "journal-title": "Jpn J Pharmacol"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib105",
      "doi-asserted-by": "crossref",
      "first-page": "171",
      "DOI": "10.1007/BF00174504",
      "article-title": "Intravenous nicotine in Alz-heimer\u2019s disease: A pilot study",
      "volume": "95",
      "author": "Newhouse",
      "year": "1988",
      "journal-title": "Psychopharmacology"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib106",
      "doi-asserted-by": "crossref",
      "first-page": "285",
      "DOI": "10.1002/ddr.430190307",
      "article-title": "DuP 996 (3,3-bis(4-pyridinylmethyl)-1-phenylindolin-2-one) enhances the stimulus-induced release of acetylcholine from rat brain in vitro and in vivo",
      "volume": "19",
      "author": "Nickolson",
      "year": "1990",
      "journal-title": "Drug Dev Res"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib107",
      "series-title": "Current Research in Alzheimer therapy",
      "first-page": "281",
      "article-title": "Metrifonate: A review",
      "author": "Nordgren",
      "year": "1988"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib108",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1016/S0026-895X(25)14382-4",
      "article-title": "Presynaptic antagonist-postsynaptic agonistat muscarinic cholinergic synapses",
      "volume": "24",
      "author": "Nordstoem",
      "year": "1983",
      "journal-title": "Mol Pharmacol"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib109",
      "series-title": "Current Research in Alzheimer Therapy",
      "first-page": "231",
      "article-title": "Preliminary experiences and results with THA for the amelioration of symptoms of Alzheimer\u2019s disease",
      "author": "Nyback",
      "year": "1988"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib110",
      "series-title": "Psychopharmacology: The Third Generation of Progress",
      "first-page": "941",
      "article-title": "Dementia: Animal models of the cognitive impairments produced by degeneration of the basal forebrain cholinergic system",
      "author": "Olton",
      "year": "1987"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib111",
      "doi-asserted-by": "crossref",
      "first-page": "77",
      "DOI": "10.1016/0014-2999(88)90404-9",
      "article-title": "Heterogeneity of muscarinic heteroreceptors in the rat brain: Effects of a novel M1 agonist, AF102B",
      "volume": "155",
      "author": "Ono",
      "year": "1988",
      "journal-title": "Eur J Pharmacol"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib112",
      "first-page": "2745",
      "article-title": "Gershon S",
      "volume": "4",
      "author": "Palmer",
      "year": "1990",
      "journal-title": "Is the neuronal basis of Alzheimer\u2019s disease cholinergic or glutamatergic FASEB J"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib113",
      "doi-asserted-by": "crossref",
      "first-page": "493",
      "DOI": "10.1111/j.1365-2044.1970.tb00255.x",
      "article-title": "Preoperative amnesia: The incidence following the intra-muscular injection of commonly used premedicants",
      "volume": "25",
      "author": "Panditt",
      "year": "1970",
      "journal-title": "Anesthesia"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib114",
      "doi-asserted-by": "crossref",
      "first-page": "130",
      "DOI": "10.1007/BF02245803",
      "article-title": "Oxiracetam and D-pyroglutamic acid antagonize a disruption of passive avoidance behaviour induced by the N-methyl-D-aspartate receptor antagonist 2-amio-5-phosphonovalerate",
      "volume": "100",
      "author": "Paoli",
      "year": "1990",
      "journal-title": "Psychopharmacology"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib115",
      "first-page": "367",
      "article-title": "Mental impairment in aging: Selection of patients, methods of evaluation and therapeutic possibilities of actyl-L-carni-tine",
      "volume": "8",
      "author": "Passeri",
      "year": "1988",
      "journal-title": "Int J Clin Pharmacol Res"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib116",
      "doi-asserted-by": "crossref",
      "first-page": "219",
      "DOI": "10.1212/WNL.38.2.219",
      "article-title": "Intraventricular bethanechol infusion of Alzheimer\u2019s disease: Results of double blind and escalating dose trials",
      "volume": "38",
      "author": "Penn",
      "year": "1988",
      "journal-title": "Neurology"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib117",
      "doi-asserted-by": "crossref",
      "first-page": "116",
      "DOI": "10.1055/s-2007-1014630",
      "article-title": "The relationship between the behavioral effects of cognition-enhancing drugs and brain acetylcholine",
      "volume": "22",
      "author": "Pepeu",
      "year": "1989",
      "journal-title": "Pharmacopsychiatry"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib118",
      "doi-asserted-by": "crossref",
      "first-page": "189",
      "DOI": "10.1016/S0140-6736(77)91780-9",
      "article-title": "Necropsy evidence of central cholinergic deficits in senile dementia",
      "volume": "1",
      "author": "Perry",
      "year": "1977",
      "journal-title": "Lancet"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib119",
      "doi-asserted-by": "crossref",
      "first-page": "1457",
      "DOI": "10.1136/bmj.2.6150.1457",
      "article-title": "Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia",
      "volume": "2",
      "author": "Perry",
      "year": "1978",
      "journal-title": "BMJ"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib120",
      "doi-asserted-by": "crossref",
      "first-page": "147",
      "DOI": "10.1097/00002826-199004000-00004",
      "article-title": "Neuropsychological effects of L-deprenyl in Alzheimer\u2019s type dementia",
      "volume": "13",
      "author": "Piccinin",
      "year": "1990",
      "journal-title": "Clin Neuropharmacol"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib121",
      "first-page": "388",
      "article-title": "Combined piracetam and cholinergic precursor treatment for primary degenerative dementia",
      "volume": "12",
      "author": "Pomara",
      "year": "1984",
      "journal-title": "IRCS Med Sci"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib122",
      "doi-asserted-by": "crossref",
      "first-page": "278",
      "DOI": "10.1002/j.1552-4604.1989.tb03328.x",
      "article-title": "Single dose safety, tolerance, and pharmacokinetics of HP 029 in healthy young men: A potential Alzheimer\u2019s agent",
      "volume": "29",
      "author": "Puri",
      "year": "1989",
      "journal-title": "J Clin Pharmacol"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib123",
      "doi-asserted-by": "crossref",
      "first-page": "638",
      "DOI": "10.1185/03007999009112690",
      "article-title": "Double-blind, placebo controlled study of acetyl-L-carnitine in patients with Alzheimer\u2019s dementia",
      "volume": "11",
      "author": "Rai",
      "year": "1990",
      "journal-title": "Curr Med Res Opin"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib124",
      "unstructured": "Rainer M, Mark TH, Haushofer A: Galanthaminum hydrobromicum in treatment of senile dementia (Alzheimer\u2019s disease). Presented at the Fourth World Conference on Clinical Pharmacology and Therapeutics, Berlin (West), July 28\u201330, 1989"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib125",
      "doi-asserted-by": "crossref",
      "first-page": "1025",
      "DOI": "10.1001/archneur.1990.00530090105020",
      "article-title": "Intracerebroventricular bethanechol for Alz-heimer\u2019s disease. Variable dose-related responses",
      "volume": "47",
      "author": "Read",
      "year": "1990",
      "journal-title": "Arch Neurol"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib126",
      "doi-asserted-by": "crossref",
      "first-page": "453",
      "DOI": "10.1016/0024-3205(87)90221-9",
      "article-title": "Decreased muscarinic receptor binding in cerebral cortex and hippocampus in Alzheimer\u2019s disease",
      "volume": "41",
      "author": "Reinikainen",
      "year": "1987",
      "journal-title": "Life Sci"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib127",
      "first-page": "45",
      "article-title": "Naloxone effects on primary degenerative dementia (PDD)",
      "volume": "19",
      "author": "Reisberg",
      "year": "1983",
      "journal-title": "Psychopharmacol Bull"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib128",
      "doi-asserted-by": "crossref",
      "first-page": "721",
      "DOI": "10.1056/NEJM198303243081213",
      "article-title": "Effects of naloxone in senile dementia: A double blind trial",
      "volume": "308",
      "author": "Reisberg",
      "year": "1983",
      "journal-title": "N Engl J Med"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib129",
      "first-page": "348",
      "article-title": "Clinical experience with a cholinesterase inhibitor (HP 029) in the treatment of Alzheimer\u2019s disease: Can it make a difference Abstracts from the Second International Conference on Alzheimer\u2019s Disease and Related Disorders",
      "volume": "11",
      "author": "Richter",
      "year": "1990",
      "journal-title": "Neurobiol Aging"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib130",
      "first-page": "158",
      "article-title": "Morphological and biochemical changes in the aging brain: Pathophysiological and possible therapeutic consequences",
      "volume": "5",
      "author": "Riederer",
      "year": "1982",
      "journal-title": "Exp Brain Res"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib131",
      "doi-asserted-by": "crossref",
      "first-page": "1575",
      "DOI": "10.1126/science.3201248",
      "article-title": "Grafting genetically modified cells to the damaged brain: Restorative effects of NGF expression",
      "volume": "242",
      "author": "Rosenberg",
      "year": "1988",
      "journal-title": "Science"
    },
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      "DOI": "10.1093/oxfordjournals.bmb.a072101",
      "article-title": "Non-cholinergic neurotransmitter abnormalities in Alzheimer\u2019s disease",
      "volume": "42",
      "author": "Rossor",
      "year": "1986",
      "journal-title": "Br Med Bull"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib133",
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      "first-page": "1",
      "DOI": "10.1111/j.1365-2125.1989.tb03500.x",
      "article-title": "EEG brain mapping in evaluating the time-course of the central action of DUP 996- a new acetylcholine releasing drug",
      "volume": "28",
      "author": "Saletu",
      "year": "1989",
      "journal-title": "Br J Clin Pharmacol"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib134",
      "doi-asserted-by": "crossref",
      "first-page": "192",
      "DOI": "10.1159/000118263",
      "article-title": "Some considerations of different modes of action of nootropic drugs",
      "volume": "15",
      "author": "Sarter",
      "year": "1986",
      "journal-title": "Neuropsychobiology"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib135",
      "doi-asserted-by": "crossref",
      "first-page": "124",
      "DOI": "10.1097/00002826-198904000-00007",
      "article-title": "Guanfacine treatment of Alzheimer\u2019s disease",
      "volume": "12",
      "author": "Schlegel",
      "year": "1989",
      "journal-title": "Clin Neuropharmacol"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib136",
      "series-title": "Alzheimer\u2019s Disease",
      "first-page": "362",
      "article-title": "Nootropics",
      "author": "Schneck",
      "year": "1983"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib137",
      "series-title": "Diagnosis and Treatment of Senile Dementia",
      "first-page": "295",
      "article-title": "Old rats as an animal model for senile dementia: Beha-vioural effects of nimodipine",
      "author": "Schuurman",
      "year": "1989"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib138",
      "doi-asserted-by": "crossref",
      "first-page": "107",
      "DOI": "10.1111/j.1532-5415.1974.tb01521.x",
      "article-title": "A new scale for clinical assessment in geriatric populations: Sandoz Clinical Assessment-Geriatric (SCAG)",
      "volume": "22",
      "author": "Shader",
      "year": "1974",
      "journal-title": "J Am Geriatr Soc"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib139",
      "doi-asserted-by": "crossref",
      "first-page": "1278",
      "DOI": "10.1021/jm00402a002",
      "article-title": "(\u00b1)-9-amino-1,2,3,4,-tetrahydroa-cridin-1-ol. A potential Alzheimer\u2019s disease therapeutic of low toxicity",
      "volume": "31",
      "author": "Shutske",
      "year": "1988",
      "journal-title": "J Med Chem"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib140",
      "doi-asserted-by": "crossref",
      "first-page": "274",
      "DOI": "10.1126/science.351808",
      "article-title": "Human serial learning: Enhancement with arecoline and impairment with scopolamine correlated with performance on placebo",
      "volume": "201",
      "author": "Sitaram",
      "year": "1978",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib141",
      "first-page": "542",
      "article-title": "Comparison of therapeutic response to long-term treatment with lecithin versus piracetam plus lecithin in patients with Alzheimer\u2019s disease",
      "volume": "20",
      "author": "Smith",
      "year": "1984",
      "journal-title": "Psychopharmacol Bull"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib142",
      "doi-asserted-by": "crossref",
      "first-page": "1126",
      "DOI": "10.1126/science.2111585",
      "article-title": "Platelet coagulation factor Ma-inhibitor, a form of Alzheimer amyloid precursor protein",
      "volume": "248",
      "author": "Smith",
      "year": "1990",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib143",
      "doi-asserted-by": "crossref",
      "first-page": "90",
      "DOI": "10.1007/BF00690933",
      "article-title": "Senile dementia of the Alzheimer\u2019s type treated with aniracetam",
      "volume": "91",
      "author": "Sourander",
      "year": "1987",
      "journal-title": "Psychopharmacology"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib144",
      "doi-asserted-by": "crossref",
      "first-page": "306",
      "DOI": "10.1002/ana.410220305",
      "article-title": "Effects of oral physostigmine in Alzheimer\u2019s disease",
      "volume": "22",
      "author": "Stern",
      "year": "1987",
      "journal-title": "Ann Neurol"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib145",
      "doi-asserted-by": "crossref",
      "first-page": "1241",
      "DOI": "10.1056/NEJM198611133152001",
      "article-title": "Oral tetrahydroaminoacridine in long-term treatment of senile dementia after Alzheimer type",
      "volume": "315",
      "author": "Summers",
      "year": "1986",
      "journal-title": "N Engl J Med"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib146",
      "doi-asserted-by": "crossref",
      "first-page": "28",
      "DOI": "10.1159/000116478",
      "article-title": "Tacrine in the treatment of Alzheimer\u2019s disease. A clinical update and recent pharmacological studies",
      "volume": "29",
      "author": "Summers",
      "year": "1989",
      "journal-title": "Eur Neurol"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib147",
      "first-page": "145",
      "article-title": "Use of THA in treatment of Alzheimer-like dementia: Pilot study in twelve patients",
      "volume": "16",
      "author": "Summers",
      "year": "1981",
      "journal-title": "Biol Psychiatry"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib148",
      "first-page": "507",
      "article-title": "Effects of huperzine A on learning and retrieval process of discrimination performance in rats",
      "volume": "7",
      "author": "Tang",
      "year": "1986",
      "journal-title": "Acta Pharmacol Sinica"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib149",
      "series-title": "Current Research in Alzheimer Therapy",
      "first-page": "289",
      "article-title": "Studies on the nootropic effects of huperzine A and B: Two selective AChE inhibitors",
      "author": "Tang",
      "year": "1988"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib150",
      "doi-asserted-by": "crossref",
      "first-page": "427",
      "DOI": "10.1001/archpsyc.1987.01800170041007",
      "article-title": "L-deprenyl in Alzheimer\u2019s disease",
      "volume": "44",
      "author": "Tariot",
      "year": "1987",
      "journal-title": "Arch Gen Psychiatry"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib151",
      "doi-asserted-by": "crossref",
      "first-page": "901",
      "DOI": "10.1001/archpsyc.1988.01800340023003",
      "article-title": "Multiple-dose arecoline infusions in Alzheimer\u2019s disease",
      "volume": "45",
      "author": "Tariot",
      "year": "1988",
      "journal-title": "Arch Gen Psychiatry"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib152",
      "doi-asserted-by": "crossref",
      "first-page": "489",
      "DOI": "10.1007/BF00216016",
      "article-title": "Cognitive effects of L-deprenyl in Alzheimer\u2019s disease",
      "volume": "91",
      "author": "Tariot",
      "year": "1987",
      "journal-title": "Psychopharmacology"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib153",
      "doi-asserted-by": "crossref",
      "first-page": "515",
      "DOI": "10.1111/j.1532-5415.1989.tb05682.x",
      "article-title": "The safety and lack of efficacy of vinpocetine in Alzheimer\u2019s disease",
      "volume": "37",
      "author": "Thal",
      "year": "1989",
      "journal-title": "J Am Geriatr Soc"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib154",
      "doi-asserted-by": "crossref",
      "first-page": "445",
      "DOI": "10.1056/NEJM199008163230704",
      "article-title": "Lack of efficacy of hydergine in patients with Alzheimer\u2019s disease",
      "volume": "323",
      "author": "Thompson",
      "year": "1990",
      "journal-title": "N Engl J Med"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib155",
      "unstructured": "Thomsen T, Kewitz H: Galanthamine treatment in senile dementia of Alzheimer\u2019s type. A case report. Presented at the Fourth World Conference on Clinical Pharmacology and Therapeutics, Berlin (West), July 28\u201330, 1989"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib156",
      "doi-asserted-by": "crossref",
      "first-page": "1133",
      "DOI": "10.1016/0006-3223(90)90050-C",
      "article-title": "Short-term effects of the calcium channel blocker nimodipine (Bay-e-9736) in the management of primary degenerative dementia",
      "volume": "27",
      "author": "Tollefson",
      "year": "1990",
      "journal-title": "Biol Psychiatry"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib157",
      "doi-asserted-by": "crossref",
      "first-page": "38",
      "DOI": "10.1001/archneur.1989.00520370040016",
      "article-title": "A community based study of parental age at the birth of patients with dementia of the Alzheimer\u2019s type",
      "volume": "46",
      "author": "Urakami",
      "year": "1989",
      "journal-title": "Arch Neurol"
    },
    {
      "issue": "14",
      "key": "10.1016/S0193-953X(18)30318-6_bib158",
      "first-page": "301",
      "article-title": "Clinical and neuropsychological investigations on oxiracetam in patients with mild to moderate dementia",
      "volume": "9",
      "author": "Villardita",
      "year": "1986",
      "journal-title": "Clin Neuropharmacol"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib159",
      "unstructured": "Vincent GP, Rummenik L, Cumin R, et al: Effects ofhuperzine A, an acetylcholinesterase inhibitor on the enhancement of memory in mice, rats, and monkeys [abstract no. 237.4]. Presented at the Society for Neuroscience, 1987"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib160",
      "first-page": "110",
      "article-title": "Anti-cholinesterase activity of huperzine A",
      "volume": "7",
      "author": "Wang",
      "year": "1986",
      "journal-title": "Acta Pharmacol Sinica"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib161",
      "doi-asserted-by": "crossref",
      "first-page": "249",
      "DOI": "10.1017/S0317167100027694",
      "article-title": "Cognitive enhancing agents: Current status in the treatment of Alz-heimer\u2019s disease",
      "volume": "15",
      "author": "Waters",
      "year": "1988",
      "journal-title": "Can J Neurol Sci"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib162",
      "doi-asserted-by": "crossref",
      "first-page": "1474",
      "DOI": "10.1126/science.2157282",
      "article-title": "The calcium channel blocker nifedipine attenuates slow excitatory amino acid neurotoxicity",
      "volume": "247",
      "author": "Weiss",
      "year": "1990",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib163",
      "doi-asserted-by": "crossref",
      "first-page": "988",
      "DOI": "10.1056/NEJM198404123101514",
      "article-title": "Effects of 4-aminopyridine in elderly patients with Alzheimer\u2019s disease",
      "volume": "310",
      "author": "Wesseling",
      "year": "1984",
      "journal-title": "N Engl J Med"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib164",
      "doi-asserted-by": "crossref",
      "first-page": "572",
      "DOI": "10.1007/BF00431470",
      "article-title": "Clinical studies with the cholinergic drug RS-86 in Alz-heimer\u2019s disease (AD) and senile dementia of Alzheimer type (SDAT)",
      "volume": "84",
      "author": "Wettstein",
      "year": "1984",
      "journal-title": "Psycho-pharmacology"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib165",
      "first-page": "175",
      "article-title": "Nicotinic and muscarinic cholinergic receptors in Alz-heimer\u2019s disease and related disorders",
      "volume": "24",
      "author": "Whitehouse",
      "year": "1987",
      "journal-title": "J Neural Transm Suppl"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib166",
      "doi-asserted-by": "crossref",
      "first-page": "1237",
      "DOI": "10.1126/science.7058341",
      "article-title": "Alzheimer\u2019s disease and senile dementia: Loss of neurons in the basal forebrain",
      "volume": "215",
      "author": "Whitehouse",
      "year": "1982",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib167",
      "doi-asserted-by": "crossref",
      "first-page": "1488",
      "DOI": "10.1126/science.2928783",
      "article-title": "Amyloid \u00df protein enhances survival of hippocampal neurons in vitro",
      "volume": "243",
      "author": "Whitson",
      "year": "1989",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib168",
      "first-page": "17",
      "article-title": "Behavioral and neurochemical effects of chronic intraventricular injections of nerve growth factor in adult rats with fimbria lesions",
      "volume": "17",
      "author": "Will",
      "year": "1985",
      "journal-title": "Brain Res"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib169",
      "doi-asserted-by": "crossref",
      "first-page": "180",
      "DOI": "10.1111/j.1749-6632.1988.tb31825.x",
      "article-title": "New intrathecal drugs in Alzheimer\u2019s disease and psycho-metric testing",
      "volume": "531",
      "author": "Wilson",
      "year": "1988",
      "journal-title": "Ann NY Acad Sci"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib170",
      "doi-asserted-by": "crossref",
      "first-page": "139",
      "DOI": "10.1097/00005053-198103000-00001",
      "article-title": "Pharmacotherapy for aged related behavioral deficiencies",
      "volume": "169",
      "author": "Wittenborn",
      "year": "1981",
      "journal-title": "J Nerv Ment Dis"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib171",
      "doi-asserted-by": "crossref",
      "first-page": "1099",
      "DOI": "10.1212/WNL.40.7.1099",
      "article-title": "DGAVP (Org 5667) in early Alz-heimer\u2019s disease patients: An international double-blind, placebo-controlled, multicenter trial",
      "volume": "40",
      "author": "Wolters",
      "year": "1990",
      "journal-title": "Neurology"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib172",
      "doi-asserted-by": "crossref",
      "first-page": "411",
      "DOI": "10.1007/BF00167042",
      "article-title": "Cholinomimetic activities of minaprine",
      "volume": "340",
      "author": "Worms",
      "year": "1989",
      "journal-title": "Naunyn Schmiedebergs Arch Pharmacol"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib173",
      "doi-asserted-by": "crossref",
      "first-page": "573",
      "DOI": "10.1002/ana.410170608",
      "article-title": "Nucleus raphe dorsalis in Alzheimer\u2019s disease: Neurofibrillary tangles and loss of large neurons",
      "volume": "17",
      "author": "Yamamoto",
      "year": "1985",
      "journal-title": "Ann Neurol"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib174",
      "doi-asserted-by": "crossref",
      "first-page": "279",
      "DOI": "10.1126/science.2218531",
      "article-title": "Neurotrophic and neurotoxic effects of amyloid fl protein: Reversal by tachykininneuropeptides",
      "volume": "250",
      "author": "Yankner",
      "year": "1990",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0193-953X(18)30318-6_bib175",
      "first-page": "260",
      "article-title": "Therapeutic effects of huperzine A on the aged with memory impair-ment",
      "volume": "5",
      "author": "Zhang",
      "year": "1986",
      "journal-title": "New Drugs Clin Remedies"
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