Crossref
journal-article
Elsevier BV
Advanced Drug Delivery Reviews (78)
References
79
Referenced
788
- M. Naito, T. Tsuruo, Role of P-glycoprotein in the blood–brain barrier. In: S. Gupta, T. Tsuruo (Eds.), Multidrug Resistance in Cancer Cells, John Wiley and Sons, Ltd., Chichester, 1996, pp. 321–333.
10.1016/S0169-409X(97)00504-8
/ Adv. Drug Deliv. Rev. / Blood–brain barrier function of P-glycoprotein by Tsuji (1997)10.1146/annurev.bi.58.070189.001033
/ Annu. Rev. Biochem. / The biochemistry of P-glycoprotein-mediated multidrug resistance by Endicott (1989)10.1016/0006-2952(92)90666-7
/ Biochem. Pharmacol. / The role of the MDR1 (P-glycoprotein) gene in multidrug resistance in vitro and in vivo by Roninson (1992)10.1146/annurev.bi.62.070193.002125
/ Annu. Rev. Biochem. / Biochemistry of multidrug resistance mediated by the multidrug transporter by Gottesman (1993)10.1016/0165-6147(94)90322-0
/ Trends Pharmacol. Sci. / A mechanism for P-glycoprotein action in multidrug resistance: are we there yet? by Ruetz (1994)10.1016/S0168-9525(97)01112-8
/ Trends Genet. / Genetic dissection of the function of mammalian P-glycoproteins by Borst (1997){'key': '10.1016/S0169-409X(98)00085-4_BIB8', 'first-page': '1', 'article-title': 'Enhanced transepithelial flux of cimetidine by Madin–Darby canine kidney cells overexpressing human P-glycoprotein', 'volume': '270', 'author': 'Pan', 'year': '1994', 'journal-title': 'J. Pharmacol. Exp. Ther.'}
/ J. Pharmacol. Exp. Ther. / Enhanced transepithelial flux of cimetidine by Madin–Darby canine kidney cells overexpressing human P-glycoprotein by Pan (1994)10.1016/S0092-8674(00)81370-7
/ Cell / MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine by Van Helvoort (1996)10.1073/pnas.93.3.1238
/ Proc. Natl. Acad. Sci. USA / P-glycoprotein confers methotrexate resistance in 3T6 cells with deficient carrier-mediated methotrexate uptake by De Graaf (1996)10.1016/0968-0004(92)90419-A
/ Trends Biochem. Sci. / Is the multidrug transporter a flippase? by Higgins (1992){'key': '10.1016/S0169-409X(98)00085-4_BIB12', 'first-page': '1967', 'article-title': 'Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil', 'volume': '41', 'author': 'Tsuruo', 'year': '1981', 'journal-title': 'Cancer Res.'}
/ Cancer Res. / Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil by Tsuruo (1981)10.1016/S0889-8588(18)30099-6
/ Hematol. Oncol. Clin. North Am. / Clinical studies with modulators of multidrug resistance by Fisher (1995){'key': '10.1016/S0169-409X(98)00085-4_BIB14', 'first-page': '67', 'article-title': 'Clinical reversal of drug resistance', 'volume': 'XIX', 'author': 'Goldstein', 'year': '1995', 'journal-title': 'Curr. Probl. Cancer'}
/ Curr. Probl. Cancer / Clinical reversal of drug resistance by Goldstein (1995){'key': '10.1016/S0169-409X(98)00085-4_BIB15', 'first-page': '4595', 'article-title': 'In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative', 'volume': '53', 'author': 'Hyafil', 'year': '1993', 'journal-title': 'Cancer Res.'}
/ Cancer Res. / In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative by Hyafil (1993){'key': '10.1016/S0169-409X(98)00085-4_BIB16', 'first-page': '7', 'article-title': 'Flow cytometric assay of modulation of P-glycoprotein function in whole blood by the multidrug resistance inhibitor GG918', 'volume': '2', 'author': 'Witherspoon', 'year': '1996', 'journal-title': 'Clin. Cancer Res.'}
/ Clin. Cancer Res. / Flow cytometric assay of modulation of P-glycoprotein function in whole blood by the multidrug resistance inhibitor GG918 by Witherspoon (1996){'key': '10.1016/S0169-409X(98)00085-4_BIB17', 'first-page': '4171', 'article-title': 'Reversal of P-glycoprotein-mediated resistance by a potent cyclopropyldibenzosuberane modulator, LY335979', 'volume': '56', 'author': 'Dantzig', 'year': '1996', 'journal-title': 'Cancer Res.'}
/ Cancer Res. / Reversal of P-glycoprotein-mediated resistance by a potent cyclopropyldibenzosuberane modulator, LY335979 by Dantzig (1996)10.1073/pnas.84.21.7735
/ Proc. Natl. Acad. Sci. USA / Cellular localization of the multidrug resistance gene product in normal human tissues by Thiebaut (1987)10.1128/MCB.9.3.1346
/ Mol. Cell. Biol. / The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues by Croop (1989)10.1073/pnas.85.12.4350
/ Proc. Natl. Acad. Sci. USA / The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus by Arceci (1988)10.1016/S0021-9258(18)80173-9
/ J. Biol. Chem. / Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells by Hsu (1989)10.1128/MCB.10.4.1652
/ Mol. Cell. Biol. / Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities by Devault (1990)10.1016/0092-8674(94)90212-7
/ Cell / Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood–brain barrier and to increased sensitivity to drugs by Schinkel (1994)10.1073/pnas.94.8.4028
/ Proc. Natl. Acad. Sci. USA / Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins by Schinkel (1997)10.1073/pnas.94.5.2031
/ Proc. Natl. Acad. Sci. USA / Limited oral bio-availability and active epithelial excretion of paclitaxel (taxol) caused by P-glycoprotein in the intestine by Sparreboom (1997)10.1038/bjc.1997.530
/ Br. J. Cancer / Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833 by Van Asperen (1997)10.1093/jnci/88.14.994
/ J. Natl. Cancer Inst. / Altered pharmacokinetics of vinblastine in mdr1a P-glycoprotein deficient mice by Van Asperen (1996)10.1111/j.1476-5381.1996.tb15775.x
/ Br. J. Pharmacol. / Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr1a P-glycoprotein by Mayer (1996)10.1172/JCI119784
/ J. Clin. Invest. / Full blockade of intestinal P-glycoprotein and extensive inhibition of blood–brain barrier P-glycoprotein by oral treatment of mice with PSC833 by Mayer (1997)10.1002/hep.510270422
/ Hepatology / Contribution of the murine mdr1a P-glycoprotein to hepatobiliary and intestinal elimination of cationic drugs as measured in mice with a mdr1a gene disruption by Smit (1998)10.1038/scientificamerican0986-74
/ Sci. Am. / The blood–brain barrier by Goldstein (1986)10.1146/annurev.pa.28.040188.000325
/ Ann. Rev. Pharmacol. Toxicol. / Recent advances in blood–brain barrier transport by Pardridge (1988)10.1113/expphysiol.1993.sp003698
/ Exp. Phys. / The blood–brain barrier by Bradbury (1993)10.1161/01.RES.57.2.213
/ Circulation Res. / The blood–brain barrier by Bradbury (1985)10.1021/jm00180a022
/ J. Med. Chem. / Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability by Levin (1980)10.1073/pnas.86.2.695
/ Proc. Natl. Acad. Sci. USA / Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood–brain barrier sites by Cordon-Cardo (1989)10.1177/37.2.2463300
/ J. Histochem. Cytochem. / Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: Evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein by Thiebaut (1989)10.1093/oxfordjournals.annonc.a057676
/ Ann. Oncol. / Distribution of multi-drug resistance-associated P-glycoprotein in normal and neoplastic human tissues by Van der Valk (1990)10.1111/j.1349-7006.1990.tb02636.x
/ Jpn. J. Cancer Res. / Specialized localization of P-glycoprotein recognized by MRK16 monoclonal antibody in endothelial cells of the brain and the spinal cord by Sugawara (1990)10.1007/BF00230349
/ Virchows Arch. / Ultrastructural localization of P-glycoprotein on capillary endothelial cells in human gliomas by Tanaka (1994){'key': '10.1016/S0169-409X(98)00085-4_BIB41', 'first-page': '853', 'article-title': 'MDR1 P-glycoprotein is expressed by endothelial cells of newly formed capillaries in human gliomas but is not expressed in the neovasculature of other primary tumors', 'volume': '149', 'author': 'Tóth', 'year': '1996', 'journal-title': 'Am. J. Pathol.'}
/ Am. J. Pathol. / MDR1 P-glycoprotein is expressed by endothelial cells of newly formed capillaries in human gliomas but is not expressed in the neovasculature of other primary tumors by Tóth (1996)-
J.B.M.M. Van Bree, A.G. de Boer, M. Danhof, D.D. Breimer, Drug transport across the blood–brain barrier. In: J.B.M.M. van Bree (Ed.), Drug Transport Across the Blood–Brain Barrier, PhD Thesis, University of Leiden, All In BV, Katwijk, 1990, pp. 8–62.
(
10.1016/0168-3659(90)90008-H
) {'key': '10.1016/S0169-409X(98)00085-4_BIB43', 'first-page': '545', 'article-title': 'Expression and functions of P-glycoprotein (mdr1 gene product) in normal and malignant tissues', 'volume': '40', 'author': 'Sugawara', 'year': '1990', 'journal-title': 'Acta Pathol. Jpn.'}
/ Acta Pathol. Jpn. / Expression and functions of P-glycoprotein (mdr1 gene product) in normal and malignant tissues by Sugawara (1990)10.1016/0024-3205(92)90537-Y
/ Life Sci. / P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells by Tsuji (1992)10.1177/44.7.8675989
/ J. Histochem. Cytochem. / Cellular localization of P-glycoprotein in brain versus gonadal capillaries by Stewart (1996)10.1016/0006-2952(95)02073-X
/ Biochem. Pharmacol. / Interaction of drugs with P-glycoprotein in brain capillaries by Jetté (1995)10.1111/j.1365-2141.1990.tb07876.x
/ Br. J. Haematol. / Expression of the multiple drug resistance gene (mdr-1) and epitope masking in chronic lymphatic leukaemia by Cumber (1990)- J.P. O'Brien, C. Cordon-Cardo, P-glycoprotein expression in normal human tissues. In: S. Gupta, T. Tsuruo (Eds.), Multidrug Resistance in Cancer Cells, John Wiley and Sons, Ltd., Chichester, 1996, pp. 285–291.
10.1177/39.12.1682363
/ J. Histochem. Cytochem. / Some monoclonal antibody reagents (C219 and JSB-1) to P-glycoprotein contain antibodies to blood group A carbohydrate determinants: a problem of quality control for immunohistochemical analysis by Finstad (1991)10.1042/bj3260539
/ Biochem. J. / P-glycoprotein is strongly expressed in the luminal membranes of the endothelium of blood vessels in the brain by Beaulieu (1997)10.1111/j.1528-1157.1995.tb01657.x
/ Epilepsia / MDR1 gene expression in brain of patients with medically intractable epilepsy by Tishler (1995)10.1046/j.1471-4159.1997.68031278.x
/ J. Neurochem. / Brain microvascular and astrocyte localization of P-glycoprotein by Pardridge (1997)10.1016/S0021-9258(19)88713-6
/ J. Biol. Chem. / Functional involvement of P-glycoprotein in blood–brain barrier by Tatsuta (1992)10.1016/0006-2952(93)90677-O
/ Biochem. Pharmacol. / Restricted transport of cyclosporin A across the blood–brain by a multidrug transporter. P-glycoprotein by Tsuji (1993){'key': '10.1016/S0169-409X(98)00085-4_BIB55', 'first-page': '6969', 'article-title': 'Expression and functional activity of P-glycoprotein in cultured cerebral capillary endothelial cells', 'volume': '52', 'author': 'Hegmann', 'year': '1992', 'journal-title': 'Cancer Res.'}
/ Cancer Res. / Expression and functional activity of P-glycoprotein in cultured cerebral capillary endothelial cells by Hegmann (1992)10.1042/bj3050761
/ Biochem. J. / Isoform I (mdr3) is the major form of P-glycoprotein expressed in mouse brain capillaries. Evidence for cross-reactivity of antibody C219 with an unrelated protein by Jetté (1995)10.1016/0014-5793(95)01104-M
/ FEBS Lett. / Comparisons of P-glycoprotein expression in isolated rat brain microvessels and in primary cultures of endothelial cells derived from microvasculature of rat brain, epididymal fat pad and from aorta by Barrand (1995)10.1016/0006-8993(95)00511-N
/ Brain Res. / Isolation and culture of human brain microvessel endothelial cells for the study of blood–brain barrier properties in vitro by Biegel (1995)10.1016/0167-4889(94)90047-7
/ Biochim. Biophys. Acta / Transport of cyclosporin A across the brain capillary endothelial cell monolayer by P-glycoprotein by Shirai (1994)10.1172/JCI118214
/ J. Clin. Invest. / Absence of the mdr1a P-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A by Schinkel (1995)10.1006/taap.1996.8086
/ Toxicol. Appl. Pharmacol. / P-glycoprotein deficiency in a subpopulation of CF-1 mice enhances avermectin-induced neurotoxicity by Lankas (1997)10.1006/taap.1997.8225
/ Toxicol. Appl. Pharmacol. / Identification of a P-glycoprotein-deficient subpopulation in the CF-1 mouse strain using a restriction fragment length polymorphism by Umbenhauer (1997){'key': '10.1016/S0169-409X(98)00085-4_BIB63', 'first-page': '33', 'article-title': 'Investigating ivermectin hypersensitivity in collies', 'volume': '80', 'author': 'Pulliam', 'year': '1985', 'journal-title': 'Vet. Med.'}
/ Vet. Med. / Investigating ivermectin hypersensitivity in collies by Pulliam (1985)10.1172/JCI118699
/ J. Clin. Invest. / P-glycoprotein in the blood–brain barrier of mice influences the brain penetration and pharmacological activity of many drugs by Schinkel (1996)10.1172/JCI1269
/ J. Clin. Invest. / The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors by Kim (1998)10.1172/JCI2575
/ J. Clin. Invest. / HIV-1 protease inhibitors and the MDR1 multidrug transporter by Lee (1998){'key': '10.1016/S0169-409X(98)00085-4_BIB67', 'first-page': '1226', 'article-title': 'Multidrug resistance-reversing agents increase vinblastine distribution in normal tissues expressing the P-glycoprotein but do not enhance drug penetration in brain and testis', 'volume': '281', 'author': 'Arboix', 'year': '1997', 'journal-title': 'J. Pharmacol. Exp. Ther.'}
/ J. Pharmacol. Exp. Ther. / Multidrug resistance-reversing agents increase vinblastine distribution in normal tissues expressing the P-glycoprotein but do not enhance drug penetration in brain and testis by Arboix (1997)10.1016/0006-2952(94)90601-7
/ Biochem. Pharmacol. / In vivo evidence for ATP-dependent and P-glycoprotein-mediated transport of cyclosporin A at the blood–brain barrier by Sakata (1994)10.1006/bbrc.1995.1872
/ Biochem. Biophys. Res. Comm. / Effect of the P-glycoprotein inhibitor, cyclosporin A, on the distribution of rhodamine-123 to the brain: an in vivo microdialysis study in freely moving rats by Wang (1995){'key': '10.1016/S0169-409X(98)00085-4_BIB70', 'first-page': '298', 'article-title': 'The effect of verapamil on the transport of peptides across the blood brain barrier in rats: kinetic evidence for an apically polarized efflux mechanism', 'volume': '273', 'author': 'Chikhale', 'year': '1995', 'journal-title': 'J. Pharmacol. Exp. Ther.'}
/ J. Pharmacol. Exp. Ther. / The effect of verapamil on the transport of peptides across the blood brain barrier in rats: kinetic evidence for an apically polarized efflux mechanism by Chikhale (1995)10.1007/s002800050515
/ Cancer Chemother. Pharmacol. / Dose-dependent brain penetration of SDZ PSC 833, a novel multidrug resistance-reversing cyclosporin, in rats by Lemaire (1996)10.1046/j.1471-4159.1996.67041688.x
/ J. Neurochem. / Role of P-glycoprotein in the blood–brain transport of colchicine and vinblastine by Drion (1996)10.1016/S0024-3205(97)00370-6
/ Life Sci. / Effect of the P-glycoprotein inhibitor, SDZ PSC 833, on the blood and brain pharmacokinetics of colchicine by Desrayaud (1997)10.1002/(SICI)1097-4547(19970701)49:1<80::AID-JNR9>3.0.CO;2-9
/ J. Neurosci. Res. / Role of P-170 P-glycoprotein in colchicine brain uptake by Drion (1997)10.1002/ijc.2910630220
/ Int. J. Cancer / Decreased biotolerability for ivermectin and cyclosporin A in mice exposed to potent P-glycoprotein inhibitors by Didier (1995)10.1073/pnas.91.1.68
/ Proc. Natl. Acad. Sci. USA / A method to determine the ability of drugs to diffuse through the blood–brain barrier by Seelig (1994){'key': '10.1016/S0169-409X(98)00085-4_BIB77', 'first-page': '681', 'article-title': 'Structure-activity relationship studies on modulators of the multidrug transporter P-glycoportein-an overview', 'volume': '107', 'author': 'Ecker', 'year': '1995', 'journal-title': 'Wien. Klin. Wochenschr.'}
/ Wien. Klin. Wochenschr. / Structure-activity relationship studies on modulators of the multidrug transporter P-glycoportein-an overview by Ecker (1995)10.1021/js9701364
/ J. Pharm. Sci. / The functional role of P-glycoprotein in the blood–brain barrier by Van Asperen (1997)10.1006/abbi.1997.0537
/ Arch. Biochem. Biophys. / Human MDR1 and mouse mdr1a P-glycoprotein alter the cellular retention and disposition of erythromycin, but not retinoic acid or benzo(a)pyrene by Schuetz (1998)
Dates
Type | When |
---|---|
Created | 23 years ago (July 25, 2002, 10:54 p.m.) |
Deposited | 4 years, 3 months ago (May 14, 2021, 11:11 a.m.) |
Indexed | 4 days, 19 hours ago (Aug. 19, 2025, 6:08 a.m.) |
Issued | 26 years, 4 months ago (April 1, 1999) |
Published | 26 years, 4 months ago (April 1, 1999) |
Published Print | 26 years, 4 months ago (April 1, 1999) |
@article{Schinkel_1999, title={P-Glycoprotein, a gatekeeper in the blood–brain barrier}, volume={36}, ISSN={0169-409X}, url={http://dx.doi.org/10.1016/s0169-409x(98)00085-4}, DOI={10.1016/s0169-409x(98)00085-4}, number={2–3}, journal={Advanced Drug Delivery Reviews}, publisher={Elsevier BV}, author={Schinkel, Alfred H}, year={1999}, month=apr, pages={179–194} }