DOI: 10.1016/s0169-328x(98)00142-9. Methylprednisolone inhibition of TNF-α expression and NF-kB activation after spinal cord injury in rats

Methylprednisolone inhibition of TNF-α expression and NF-kB activation after spinal cord injury in rats

10.1016/s0169-328x(98)00142-9

Crossref journal-article

Elsevier BV

Molecular Brain Research (78)

Bibliography

Xu, J., Fan, G., Chen, S., Wu, Y., Xu, X. M., & Hsu, C. Y. (1998). Methylprednisolone inhibition of TNF-Î± expression and NF-kB activation after spinal cord injury in rats. Molecular Brain Research, 59(2), 135â142.

Authors 6

Jan Xu (first)
Guangshun Fan (additional)
Shawei Chen (additional)
Yingji Wu (additional)
Xiao Ming Xu (additional)
Chung Y. Hsu (additional)

References 58 Referenced 179

10.1002/ana.410330508 / Ann. Neurol. / Expression of c-fos and c-jun family genes after focal cerebral ischemia by An (1993)
10.3171/jns.1988.69.4.0562 / J. Neurosurg. / Effects of treatment with U74006 F on neurological recovery following experimental spinal cord injury by Anderson (1988)
10.1126/science.270.5234.286 / Science / Immunosuppression by glucocorticoids, inhibition of NF-kB activity through induction of IkB synthesis by Auphan (1995)
10.1146/annurev.iy.12.040194.001041 / Am. Rev. Immunol. / Functional activation of NF-kB in immune system by Baeuerle (1994)
{'key': '10.1016/S0169-328X(98)00142-9_BIB5', 'first-page': '236', 'article-title': 'Pathology of experimental spinal cord trauma', 'volume': '39', 'author': 'Balentine', 'year': '1978', 'journal-title': 'Lab. Invest.'} / Lab. Invest. / Pathology of experimental spinal cord trauma by Balentine (1978)
{'key': '10.1016/S0169-328X(98)00142-9_BIB6', 'first-page': '236', 'article-title': 'Pathology of experimental spinal cord trauma. I. The necrotic lesion as a function of vascular injury', 'volume': '39', 'author': 'Balentine', 'year': '1978', 'journal-title': 'Lab. Invest.'} / Lab. Invest. / Pathology of experimental spinal cord trauma. I. The necrotic lesion as a function of vascular injury by Balentine (1978)
10.1111/j.1460-9568.1997.tb01497.x / J. Neurosci. / Expression of pro-inflammatory cytokine and chemokine mRNA upon experimental spinal cord injury in mouse, an in situ hybridization study, Europe by Bartholdi (1997)
10.1016/0006-8993(94)01410-J / Brain Res. / Methylprednisolone inhibits early inflammatory processes but not ischemic cell death after experimental spinal cord lesion in the rat by Bartholdi (1995)
10.1006/exnr.1996.0098 / Exp. Neurol. / Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection by Basso (1996)
10.1093/brain/118.3.735 / Brain / Quinolinic acid accumulation and functional deficits following experimental spinal cord injury by Blight (1995)
{'key': '10.1016/S0169-328X(98)00142-9_BIB11', 'first-page': 'S83', 'article-title': 'Macrophages and inflammatory damage in spinal cord injury', 'volume': '9', 'author': 'Blight', 'year': '1992', 'journal-title': 'J. Neurotrauma'} / J. Neurotrauma / Macrophages and inflammatory damage in spinal cord injury by Blight (1992)
10.1056/NEJM199005173222001 / NEJM / A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal cord injury by Bracken (1990)
10.3171/jns.1982.56.6.0838 / J. Neurosurg. / Correlation of methylprednisolone levels in cat spinal cord with its effects on (Na2+K+)-ATPase, lipid peroxidation, and alpha motor neuron function by Braughler (1982)
10.1016/0306-4522(95)00414-9 / Neuroscience / Expression of tumor necrosis factor alpha after focal ischemia in the rat by Buttini (1996)
10.1210/me.9.4.401 / Mol. Endocrinol. / Negative cross-talk between RelA and the glucocorticoid receptor, a possible mechanism for the antiinflammatory action of glucocorticoids by Caldenhoven (1995)
10.1006/exnr.1996.0065 / Exp. Neurol. / Methylprednisolone administration improves axonal regeneration into Schwann cell grafts in transected adult rat thoracic spinal cord by Chen (1996)
10.1161/01.STR.28.5.1073 / Stroke / Global ischemia activates nuclear factor-kB in forebrain neurons of rats by Clements (1997)
10.3171/jns.1994.80.1.0097 / J. Neurosurg. / The effects of methylprednisolone and the ganglioside GM1 on acute spinal cord injury in rats by Constantini (1994)
10.1073/pnas.82.20.7071 / Proc. Natl. Acad. Sci. / Membrane lipid changes in laminectomized and traumatized cat spinal cord by Demediuk (1985)
10.1111/j.1460-9568.1994.tb00983.x / Eur. J. Neurosci. / Secondary cell death and the inflammatory reaction after dorsal hemisection of the rat spinal cord by Dusart (1994)
10.1002/(SICI)1096-9861(19960729)371:3<469::AID-CNE9>3.0.CO;2-0 / J. Comp. Neurol. / Genetic influences on cellular reactions to spinal cord injury—activation of macrophages/microglia and astrocytes is delayed in mice carrying a mutation (wld(s)) that causes delayed Wallerian degeneration by Fujiki (1996)
L.A. Ghodosh, Mobility shift DNA binding assay using gel electrophoresis, in: F. Ausubel. R. Brent, R.E. Kingston et al. (Eds.), Current Protocols in Molecular Biology, Greene Publishing, New York, 1989, pp. 12.2–12.7.
10.4049/jimmunol.153.5.1963 / J. Immunol. / TNF receptor TR 60 and TR80 can mediate apoptosis via induction of distinct signal pathway by Grell (1994)
10.1007/BF00689554 / Acta Neuropathol. / Early vascular changes in the spinal gray matter following impact injury by Griffiths (1978)
10.1089/neu.1992.9.123 / J. Neurotrauma / A monitored contusion model of spinal cord injury in the rat by Gruner (1992)
10.1016/0090-3019(82)90140-9 / Surg. Neurol. / Glucocorticoid mechanisms in acute spinal cord injury, a review and therapeutic rationale by Hall (1982)
10.1046/j.1471-4159.1996.66041525.x / J. Neurochem. / Involvement of an intercellular adhesion molecule 1-dependent pathway in the pathogenesis of secondary changes after spinal cord injury in rats by Hamada (1996)
10.1016/S0022-5223(95)70027-7 / J. Thorac. Cardiovasc. Surg. / Aprotinin and methylprednisolone equally blunt cardiopulmonary bypass-induced inflammation in humans by Hill (1995)
10.1016/0006-8993(87)90366-0 / Brain Res. / A comparative study of the immunohistochemical localization of a presumptive proctolin-like peptide, thyrotropin-releasing hormone and 5-hydroxytryptamine in the rat central nervous system by Holets (1987)
10.1089/neu.1990.7.115 / J. Neurotrauma / Methylprednisolone in spinal cord injury, the possible mechanism of action by Hsu (1990)
C.Y. Hsu, K. Doster, Z.Y. Hu, Cell-mediated injury, in: K. Narayan, J.E. Wilberger Jr., P.T. Polishock (Eds.), Neurotrauma: A Comprehensive Textbook of Head and Spinal Cord injury, McGraw-Hill, St. Louis, MO, 1996, pp. 1433–1444.
10.1212/WNL.35.7.1003 / Neurology / Alternation of thromboxane and prostacylin levels in experimental spinal cord injury by Hsu (1985)
10.1016/0022-510X(86)90114-0 / J. Neurol. Sci. / Increased thromboxane level in experimental spinal cord injury by Hsu (1986)
10.1016/0022-510X(88)90019-6 / J. Neurol. Sci. / Temporal profile of thromboxane–prostacyclin imbalance in experimental spinal cord injury by Hsu (1988)
10.1016/0022-510X(85)90169-8 / J. Neurol. Sci. / Vascular permeability in experimental spinal cord injury by Hsu (1985)
10.1055/s-0038-1655974 / Thromb. Haemost. / C5a induces tissue factor activity on endothelial cells by Ikeda (1997)
{'key': '10.1016/S0169-328X(98)00142-9_BIB37', 'first-page': '496', 'article-title': 'Modulation of glomerular structure and function in murine lupus nephritis by methylprednisolone and cyclophosphamide', 'volume': '124', 'author': 'Kiberd', 'year': '1994', 'journal-title': 'J. Lab. Clin. Med.'} / J. Lab. Clin. Med. / Modulation of glomerular structure and function in murine lupus nephritis by methylprednisolone and cyclophosphamide by Kiberd (1994)
10.1016/0092-8674(89)90833-7 / Cell / NF-kB, a pleiotropic mediator of inducible and tissue-specific gene control by Lenardo (1989)
10.1159/000211403 / Skin Pharmacol. / Modulation of in vitro cytokine release from human leudemic mast cells by glucocorticoids by Lippert (1996)
10.1161/01.STR.25.7.1481 / Stroke / Tumor necrosis factor alpha expression in ischemic neurons by Liu (1994)
10.1523/JNEUROSCI.17-14-05395.1997 / J. Neurosci. / Neuronal and glial apoptosis after traumatic spinal cord injury by Liu (1997)
10.3171/jns.1981.55.2.0200 / J. Neurosurg. / Effect of methylprednisolone in compression trauma to the feline spinal cord by Means (1981)
10.1016/S0021-9258(17)36831-X / J. Biol. Chem. / Novel mechanism of glucocorticoid-mediated gene repression by Mukaida (1994)
10.1002/(SICI)1097-4547(19960815)45:4<349::AID-JNR4>3.0.CO;2-9 / J. Neurosci. Res. / Concept of autoimmunity following spinal cord injury—possible roles for t lymphocytes in the traumatized central nervous system by Popovich (1996)
10.1002/(SICI)1096-9861(19970120)377:3<443::AID-CNE10>3.0.CO;2-S / J. Comparative Neurol. / Cellular inflammatory response after spinal cord injury in Sprague–Dawley and Lewis rats by Popovich (1997)
10.1016/0163-7258(95)02033-0 / Pharmacology and Therapeutics / Cytokines and their receptors in the central nervous system—physiology, pharmacology, and pathology by Rothwell (1996)
10.1006/bbrc.1995.2060 / Biochem. Biophys. Res. Commun. / Alteration of transcription factor binding activities in the ischemic brain by Salminen (1995)
10.1128/MCB.15.2.943 / Mol. Cell Biol. / Characterization of mechanism involved in transrepression of NF-kB by activated glucocorticoid receptors by Scheinman (1995)
10.3109/10715769209079515 / Free Radical Res. Comm. / Nuclear factor kappa B, an oxidative stress-responsive transcription factor of eukaryotic cells (a review) by Schreck (1992)
10.1002/j.1460-2075.1991.tb07761.x / EMBO J. / Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1 by Schreck (1991)
10.3171/jns.1981.54.6.0802 / J. Neurosurg. / Effect of trauma dose on spinal cord edema by Wagner (1981)
10.1016/0165-5728(96)00080-X / J. Neuroimmunol. / Production of tumor necrosis factor in spinal cord following traumatic injury in rats by Wang (1996)
10.1006/bbrc.1997.6800 / Biochem. Biophys. Res. Commun. / Regulation of cytokine-induced iNOS expression by a hairpin oligonucleotide in murine cerebral endothelial cells by Xu (1997)
10.1111/j.1471-4159.1990.tb04577.x / J. Neurochem. / Leukotriene B4 and polymorphonuclear cell infiltration in spinal cord injury by Xu (1990)
10.1089/neu.1992.9.245 / J. Neurotrauma / Effect of methylprednisolone on vascular permeability on rat spinal cord injury by Xu (1992)
10.1007/BF02815410 / Mol. Chem. Neuropathol. / Sequential expression of c-fos protooncogene, TNF-alpha, and dynorphin gene in spinal cord following experimental traumatic injury by Yakovlev (1994)
10.3171/jns.1982.57.5.0667 / J. Neurosurg. / Effect of high-dose corticosteroid therapy on blood flow, evoked potentials, and extracellular calcium in experimental spinal injury by Young (1982)
10.1002/(SICI)1096-9861(19960729)371:3<485::AID-CNE10>3.0.CO;2-I / J. Comparative Neurol. / Genetic influences on cellular reactions to spinal cord injury—a wound-healing response present in normal mice is impaired in mice carrying a mutation (wld(s)) that causes delayed wallerian degeneration by Zhang (1996)

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 6:50 p.m.)
Deposited	1 year, 8 months ago (Jan. 1, 2024, noon)
Indexed	52 minutes ago (Sept. 3, 2025, 6:52 a.m.)
Issued	27 years, 1 month ago (Aug. 1, 1998)
Published	27 years, 1 month ago (Aug. 1, 1998)
Published Print	27 years, 1 month ago (Aug. 1, 1998)

Funders 0

None

BibTeX

@article{Xu_1998, title={Methylprednisolone inhibition of TNF-α expression and NF-kB activation after spinal cord injury in rats}, volume={59}, ISSN={0169-328X}, url={http://dx.doi.org/10.1016/s0169-328x(98)00142-9}, DOI={10.1016/s0169-328x(98)00142-9}, number={2}, journal={Molecular Brain Research}, publisher={Elsevier BV}, author={Xu, Jan and Fan, Guangshun and Chen, Shawei and Wu, Yingji and Xu, Xiao Ming and Hsu, Chung Y.}, year={1998}, month=aug, pages={135–142} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        9,
        3
      ]
    ],
    "date-time": "2025-09-03T10:52:55Z",
    "timestamp": 1756896775758
  },
  "reference-count": 58,
  "publisher": "Elsevier BV",
  "issue": "2",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1998,
            8,
            1
          ]
        ],
        "date-time": "1998-08-01T00:00:00Z",
        "timestamp": 901929600000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1998,
        8
      ]
    ]
  },
  "DOI": "10.1016/s0169-328x(98)00142-9",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        7,
        25
      ]
    ],
    "date-time": "2002-07-25T22:50:49Z",
    "timestamp": 1027637449000
  },
  "page": "135-142",
  "source": "Crossref",
  "is-referenced-by-count": 179,
  "title": "Methylprednisolone inhibition of TNF-\u03b1 expression and NF-kB activation after spinal cord injury in rats",
  "prefix": "10.1016",
  "volume": "59",
  "author": [
    {
      "given": "Jan",
      "family": "Xu",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Guangshun",
      "family": "Fan",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Shawei",
      "family": "Chen",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Yingji",
      "family": "Wu",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Xiao Ming",
      "family": "Xu",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Chung Y.",
      "family": "Hsu",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB1",
      "doi-asserted-by": "crossref",
      "first-page": "457",
      "DOI": "10.1002/ana.410330508",
      "article-title": "Expression of c-fos and c-jun family genes after focal cerebral ischemia",
      "volume": "33",
      "author": "An",
      "year": "1993",
      "journal-title": "Ann. Neurol."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "562",
      "DOI": "10.3171/jns.1988.69.4.0562",
      "article-title": "Effects of treatment with U74006 F on neurological recovery following experimental spinal cord injury",
      "volume": "69",
      "author": "Anderson",
      "year": "1988",
      "journal-title": "J. Neurosurg."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "286",
      "DOI": "10.1126/science.270.5234.286",
      "article-title": "Immunosuppression by glucocorticoids, inhibition of NF-kB activity through induction of IkB synthesis",
      "volume": "270",
      "author": "Auphan",
      "year": "1995",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB4",
      "doi-asserted-by": "crossref",
      "first-page": "141",
      "DOI": "10.1146/annurev.iy.12.040194.001041",
      "article-title": "Functional activation of NF-kB in immune system",
      "volume": "12",
      "author": "Baeuerle",
      "year": "1994",
      "journal-title": "Am. Rev. Immunol."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB5",
      "first-page": "236",
      "article-title": "Pathology of experimental spinal cord trauma",
      "volume": "39",
      "author": "Balentine",
      "year": "1978",
      "journal-title": "Lab. Invest."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB6",
      "first-page": "236",
      "article-title": "Pathology of experimental spinal cord trauma. I. The necrotic lesion as a function of vascular injury",
      "volume": "39",
      "author": "Balentine",
      "year": "1978",
      "journal-title": "Lab. Invest."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "1422",
      "DOI": "10.1111/j.1460-9568.1997.tb01497.x",
      "article-title": "Expression of pro-inflammatory cytokine and chemokine mRNA upon experimental spinal cord injury in mouse, an in situ hybridization study, Europe",
      "volume": "9",
      "author": "Bartholdi",
      "year": "1997",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB8",
      "doi-asserted-by": "crossref",
      "first-page": "177",
      "DOI": "10.1016/0006-8993(94)01410-J",
      "article-title": "Methylprednisolone inhibits early inflammatory processes but not ischemic cell death after experimental spinal cord lesion in the rat",
      "volume": "672",
      "author": "Bartholdi",
      "year": "1995",
      "journal-title": "Brain Res."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "244",
      "DOI": "10.1006/exnr.1996.0098",
      "article-title": "Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection",
      "volume": "139",
      "author": "Basso",
      "year": "1996",
      "journal-title": "Exp. Neurol."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "735",
      "DOI": "10.1093/brain/118.3.735",
      "article-title": "Quinolinic acid accumulation and functional deficits following experimental spinal cord injury",
      "volume": "118",
      "author": "Blight",
      "year": "1995",
      "journal-title": "Brain"
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB11",
      "first-page": "S83",
      "article-title": "Macrophages and inflammatory damage in spinal cord injury",
      "volume": "9",
      "author": "Blight",
      "year": "1992",
      "journal-title": "J. Neurotrauma"
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "1405",
      "DOI": "10.1056/NEJM199005173222001",
      "article-title": "A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal cord injury",
      "volume": "322",
      "author": "Bracken",
      "year": "1990",
      "journal-title": "NEJM"
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "838",
      "DOI": "10.3171/jns.1982.56.6.0838",
      "article-title": "Correlation of methylprednisolone levels in cat spinal cord with its effects on (Na2+K+)-ATPase, lipid peroxidation, and alpha motor neuron function",
      "volume": "56",
      "author": "Braughler",
      "year": "1982",
      "journal-title": "J. Neurosurg."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1016/0306-4522(95)00414-9",
      "article-title": "Expression of tumor necrosis factor alpha after focal ischemia in the rat",
      "volume": "71",
      "author": "Buttini",
      "year": "1996",
      "journal-title": "Neuroscience"
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "401",
      "DOI": "10.1210/me.9.4.401",
      "article-title": "Negative cross-talk between RelA and the glucocorticoid receptor, a possible mechanism for the antiinflammatory action of glucocorticoids",
      "volume": "9",
      "author": "Caldenhoven",
      "year": "1995",
      "journal-title": "Mol. Endocrinol."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "261",
      "DOI": "10.1006/exnr.1996.0065",
      "article-title": "Methylprednisolone administration improves axonal regeneration into Schwann cell grafts in transected adult rat thoracic spinal cord",
      "volume": "138",
      "author": "Chen",
      "year": "1996",
      "journal-title": "Exp. Neurol."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "1073",
      "DOI": "10.1161/01.STR.28.5.1073",
      "article-title": "Global ischemia activates nuclear factor-kB in forebrain neurons of rats",
      "volume": "28",
      "author": "Clements",
      "year": "1997",
      "journal-title": "Stroke"
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "97",
      "DOI": "10.3171/jns.1994.80.1.0097",
      "article-title": "The effects of methylprednisolone and the ganglioside GM1 on acute spinal cord injury in rats",
      "volume": "80",
      "author": "Constantini",
      "year": "1994",
      "journal-title": "J. Neurosurg."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "7071",
      "DOI": "10.1073/pnas.82.20.7071",
      "article-title": "Membrane lipid changes in laminectomized and traumatized cat spinal cord",
      "volume": "82",
      "author": "Demediuk",
      "year": "1985",
      "journal-title": "Proc. Natl. Acad. Sci."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "712",
      "DOI": "10.1111/j.1460-9568.1994.tb00983.x",
      "article-title": "Secondary cell death and the inflammatory reaction after dorsal hemisection of the rat spinal cord",
      "volume": "6",
      "author": "Dusart",
      "year": "1994",
      "journal-title": "Eur. J. Neurosci."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB21",
      "doi-asserted-by": "crossref",
      "first-page": "469",
      "DOI": "10.1002/(SICI)1096-9861(19960729)371:3<469::AID-CNE9>3.0.CO;2-0",
      "article-title": "Genetic influences on cellular reactions to spinal cord injury\u2014activation of macrophages/microglia and astrocytes is delayed in mice carrying a mutation (wld(s)) that causes delayed Wallerian degeneration",
      "volume": "371",
      "author": "Fujiki",
      "year": "1996",
      "journal-title": "J. Comp. Neurol."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB22",
      "unstructured": "L.A. Ghodosh, Mobility shift DNA binding assay using gel electrophoresis, in: F. Ausubel. R. Brent, R.E. Kingston et al. (Eds.), Current Protocols in Molecular Biology, Greene Publishing, New York, 1989, pp. 12.2\u201312.7."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "1963",
      "DOI": "10.4049/jimmunol.153.5.1963",
      "article-title": "TNF receptor TR 60 and TR80 can mediate apoptosis via induction of distinct signal pathway",
      "volume": "153",
      "author": "Grell",
      "year": "1994",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "33",
      "DOI": "10.1007/BF00689554",
      "article-title": "Early vascular changes in the spinal gray matter following impact injury",
      "volume": "41",
      "author": "Griffiths",
      "year": "1978",
      "journal-title": "Acta Neuropathol."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "123",
      "DOI": "10.1089/neu.1992.9.123",
      "article-title": "A monitored contusion model of spinal cord injury in the rat",
      "volume": "9",
      "author": "Gruner",
      "year": "1992",
      "journal-title": "J. Neurotrauma"
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB26",
      "doi-asserted-by": "crossref",
      "first-page": "320",
      "DOI": "10.1016/0090-3019(82)90140-9",
      "article-title": "Glucocorticoid mechanisms in acute spinal cord injury, a review and therapeutic rationale",
      "volume": "18",
      "author": "Hall",
      "year": "1982",
      "journal-title": "Surg. Neurol."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB27",
      "doi-asserted-by": "crossref",
      "first-page": "1525",
      "DOI": "10.1046/j.1471-4159.1996.66041525.x",
      "article-title": "Involvement of an intercellular adhesion molecule 1-dependent pathway in the pathogenesis of secondary changes after spinal cord injury in rats",
      "volume": "6",
      "author": "Hamada",
      "year": "1996",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "1658",
      "DOI": "10.1016/S0022-5223(95)70027-7",
      "article-title": "Aprotinin and methylprednisolone equally blunt cardiopulmonary bypass-induced inflammation in humans",
      "volume": "110",
      "author": "Hill",
      "year": "1995",
      "journal-title": "J. Thorac. Cardiovasc. Surg."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "141",
      "DOI": "10.1016/0006-8993(87)90366-0",
      "article-title": "A comparative study of the immunohistochemical localization of a presumptive proctolin-like peptide, thyrotropin-releasing hormone and 5-hydroxytryptamine in the rat central nervous system",
      "volume": "408",
      "author": "Holets",
      "year": "1987",
      "journal-title": "Brain Res."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "115",
      "DOI": "10.1089/neu.1990.7.115",
      "article-title": "Methylprednisolone in spinal cord injury, the possible mechanism of action",
      "volume": "7",
      "author": "Hsu",
      "year": "1990",
      "journal-title": "J. Neurotrauma"
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB31",
      "unstructured": "C.Y. Hsu, K. Doster, Z.Y. Hu, Cell-mediated injury, in: K. Narayan, J.E. Wilberger Jr., P.T. Polishock (Eds.), Neurotrauma: A Comprehensive Textbook of Head and Spinal Cord injury, McGraw-Hill, St. Louis, MO, 1996, pp. 1433\u20131444."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "1003",
      "DOI": "10.1212/WNL.35.7.1003",
      "article-title": "Alternation of thromboxane and prostacylin levels in experimental spinal cord injury",
      "volume": "35",
      "author": "Hsu",
      "year": "1985",
      "journal-title": "Neurology"
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "289",
      "DOI": "10.1016/0022-510X(86)90114-0",
      "article-title": "Increased thromboxane level in experimental spinal cord injury",
      "volume": "74",
      "author": "Hsu",
      "year": "1986",
      "journal-title": "J. Neurol. Sci."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "55",
      "DOI": "10.1016/0022-510X(88)90019-6",
      "article-title": "Temporal profile of thromboxane\u2013prostacyclin imbalance in experimental spinal cord injury",
      "volume": "83",
      "author": "Hsu",
      "year": "1988",
      "journal-title": "J. Neurol. Sci."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "275",
      "DOI": "10.1016/0022-510X(85)90169-8",
      "article-title": "Vascular permeability in experimental spinal cord injury",
      "volume": "70",
      "author": "Hsu",
      "year": "1985",
      "journal-title": "J. Neurol. Sci."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB36",
      "doi-asserted-by": "crossref",
      "first-page": "394",
      "DOI": "10.1055/s-0038-1655974",
      "article-title": "C5a induces tissue factor activity on endothelial cells",
      "volume": "77",
      "author": "Ikeda",
      "year": "1997",
      "journal-title": "Thromb. Haemost."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB37",
      "first-page": "496",
      "article-title": "Modulation of glomerular structure and function in murine lupus nephritis by methylprednisolone and cyclophosphamide",
      "volume": "124",
      "author": "Kiberd",
      "year": "1994",
      "journal-title": "J. Lab. Clin. Med."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB38",
      "doi-asserted-by": "crossref",
      "first-page": "227",
      "DOI": "10.1016/0092-8674(89)90833-7",
      "article-title": "NF-kB, a pleiotropic mediator of inducible and tissue-specific gene control",
      "volume": "58",
      "author": "Lenardo",
      "year": "1989",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB39",
      "doi-asserted-by": "crossref",
      "first-page": "93",
      "DOI": "10.1159/000211403",
      "article-title": "Modulation of in vitro cytokine release from human leudemic mast cells by glucocorticoids",
      "volume": "9",
      "author": "Lippert",
      "year": "1996",
      "journal-title": "Skin Pharmacol."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "1481",
      "DOI": "10.1161/01.STR.25.7.1481",
      "article-title": "Tumor necrosis factor alpha expression in ischemic neurons",
      "volume": "25",
      "author": "Liu",
      "year": "1994",
      "journal-title": "Stroke"
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB41",
      "doi-asserted-by": "crossref",
      "first-page": "5395",
      "DOI": "10.1523/JNEUROSCI.17-14-05395.1997",
      "article-title": "Neuronal and glial apoptosis after traumatic spinal cord injury",
      "volume": "17",
      "author": "Liu",
      "year": "1997",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB42",
      "doi-asserted-by": "crossref",
      "first-page": "200",
      "DOI": "10.3171/jns.1981.55.2.0200",
      "article-title": "Effect of methylprednisolone in compression trauma to the feline spinal cord",
      "volume": "55",
      "author": "Means",
      "year": "1981",
      "journal-title": "J. Neurosurg."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB43",
      "doi-asserted-by": "crossref",
      "first-page": "13289",
      "DOI": "10.1016/S0021-9258(17)36831-X",
      "article-title": "Novel mechanism of glucocorticoid-mediated gene repression",
      "volume": "269",
      "author": "Mukaida",
      "year": "1994",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB44",
      "doi-asserted-by": "crossref",
      "first-page": "349",
      "DOI": "10.1002/(SICI)1097-4547(19960815)45:4<349::AID-JNR4>3.0.CO;2-9",
      "article-title": "Concept of autoimmunity following spinal cord injury\u2014possible roles for t lymphocytes in the traumatized central nervous system",
      "volume": "45",
      "author": "Popovich",
      "year": "1996",
      "journal-title": "J. Neurosci. Res."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB45",
      "doi-asserted-by": "crossref",
      "first-page": "443",
      "DOI": "10.1002/(SICI)1096-9861(19970120)377:3<443::AID-CNE10>3.0.CO;2-S",
      "article-title": "Cellular inflammatory response after spinal cord injury in Sprague\u2013Dawley and Lewis rats",
      "volume": "377",
      "author": "Popovich",
      "year": "1997",
      "journal-title": "J. Comparative Neurol."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB46",
      "doi-asserted-by": "crossref",
      "first-page": "85",
      "DOI": "10.1016/0163-7258(95)02033-0",
      "article-title": "Cytokines and their receptors in the central nervous system\u2014physiology, pharmacology, and pathology",
      "volume": "69",
      "author": "Rothwell",
      "year": "1996",
      "journal-title": "Pharmacology and Therapeutics"
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB47",
      "doi-asserted-by": "crossref",
      "first-page": "939",
      "DOI": "10.1006/bbrc.1995.2060",
      "article-title": "Alteration of transcription factor binding activities in the ischemic brain",
      "volume": "212",
      "author": "Salminen",
      "year": "1995",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB48",
      "doi-asserted-by": "crossref",
      "first-page": "943",
      "DOI": "10.1128/MCB.15.2.943",
      "article-title": "Characterization of mechanism involved in transrepression of NF-kB by activated glucocorticoid receptors",
      "volume": "15",
      "author": "Scheinman",
      "year": "1995",
      "journal-title": "Mol. Cell Biol."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB49",
      "doi-asserted-by": "crossref",
      "first-page": "221",
      "DOI": "10.3109/10715769209079515",
      "article-title": "Nuclear factor kappa B, an oxidative stress-responsive transcription factor of eukaryotic cells (a review)",
      "volume": "17",
      "author": "Schreck",
      "year": "1992",
      "journal-title": "Free Radical Res. Comm."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB50",
      "doi-asserted-by": "crossref",
      "first-page": "2247",
      "DOI": "10.1002/j.1460-2075.1991.tb07761.x",
      "article-title": "Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1",
      "volume": "10",
      "author": "Schreck",
      "year": "1991",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB51",
      "doi-asserted-by": "crossref",
      "first-page": "802",
      "DOI": "10.3171/jns.1981.54.6.0802",
      "article-title": "Effect of trauma dose on spinal cord edema",
      "volume": "54",
      "author": "Wagner",
      "year": "1981",
      "journal-title": "J. Neurosurg."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB52",
      "doi-asserted-by": "crossref",
      "first-page": "151",
      "DOI": "10.1016/0165-5728(96)00080-X",
      "article-title": "Production of tumor necrosis factor in spinal cord following traumatic injury in rats",
      "volume": "69",
      "author": "Wang",
      "year": "1996",
      "journal-title": "J. Neuroimmunol."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB53",
      "doi-asserted-by": "crossref",
      "first-page": "394",
      "DOI": "10.1006/bbrc.1997.6800",
      "article-title": "Regulation of cytokine-induced iNOS expression by a hairpin oligonucleotide in murine cerebral endothelial cells",
      "volume": "235",
      "author": "Xu",
      "year": "1997",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB54",
      "doi-asserted-by": "crossref",
      "first-page": "907",
      "DOI": "10.1111/j.1471-4159.1990.tb04577.x",
      "article-title": "Leukotriene B4 and polymorphonuclear cell infiltration in spinal cord injury",
      "volume": "55",
      "author": "Xu",
      "year": "1990",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB55",
      "doi-asserted-by": "crossref",
      "first-page": "245",
      "DOI": "10.1089/neu.1992.9.245",
      "article-title": "Effect of methylprednisolone on vascular permeability on rat spinal cord injury",
      "volume": "9",
      "author": "Xu",
      "year": "1992",
      "journal-title": "J. Neurotrauma"
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB56",
      "doi-asserted-by": "crossref",
      "first-page": "179",
      "DOI": "10.1007/BF02815410",
      "article-title": "Sequential expression of c-fos protooncogene, TNF-alpha, and dynorphin gene in spinal cord following experimental traumatic injury",
      "volume": "23",
      "author": "Yakovlev",
      "year": "1994",
      "journal-title": "Mol. Chem. Neuropathol."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB57",
      "doi-asserted-by": "crossref",
      "first-page": "667",
      "DOI": "10.3171/jns.1982.57.5.0667",
      "article-title": "Effect of high-dose corticosteroid therapy on blood flow, evoked potentials, and extracellular calcium in experimental spinal injury",
      "volume": "57",
      "author": "Young",
      "year": "1982",
      "journal-title": "J. Neurosurg."
    },
    {
      "key": "10.1016/S0169-328X(98)00142-9_BIB58",
      "doi-asserted-by": "crossref",
      "first-page": "485",
      "DOI": "10.1002/(SICI)1096-9861(19960729)371:3<485::AID-CNE10>3.0.CO;2-I",
      "article-title": "Genetic influences on cellular reactions to spinal cord injury\u2014a wound-healing response present in normal mice is impaired in mice carrying a mutation (wld(s)) that causes delayed wallerian degeneration",
      "volume": "371",
      "author": "Zhang",
      "year": "1996",
      "journal-title": "J. Comparative Neurol."
    }
  ],
  "container-title": "Molecular Brain Research",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0169328X98001429?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0169328X98001429?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2024,
        1,
        1
      ]
    ],
    "date-time": "2024-01-01T17:00:56Z",
    "timestamp": 1704128456000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0169328X98001429"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1998,
        8
      ]
    ]
  },
  "references-count": 58,
  "journal-issue": {
    "issue": "2",
    "published-print": {
      "date-parts": [
        [
          1998,
          8
        ]
      ]
    }
  },
  "alternative-id": [
    "S0169328X98001429"
  ],
  "URL": "http://dx.doi.org/10.1016/S0169-328X(98)00142-9",
  "relation": {},
  "ISSN": [
    "0169-328X"
  ],
  "subject": [],
  "container-title-short": "Molecular Brain Research",
  "published": {
    "date-parts": [
      [
        1998,
        8
      ]
    ]
  }
}