DOI: 10.1016/s0167-7799(97)01067-6. Flux analysis of underdetermined metabolic networks: the quest for the missing constraints

Flux analysis of underdetermined metabolic networks: the quest for the missing constraints

10.1016/s0167-7799(97)01067-6

Crossref journal-article

Elsevier BV

Trends in Biotechnology (78)

Bibliography

Bonarius, H. P. J., Schmid, G., & Tramper, J. (1997). Flux analysis of underdetermined metabolic networks: the quest for the missing constraints. Trends in Biotechnology, 15(8), 308â314.

Authors 3

Hendrik P.J. Bonarius (first)
Georg Schmid (additional)
Johannes Tramper (additional)

References 30 Referenced 259

10.1126/science.36664 / Science by Shulman (1979)
10.1038/nbt1094-994 / Biotechnology by Varma (1994)
{'key': '10.1016/S0167-7799(97)01067-6_bib3', 'series-title': 'Frontiers in Bioprocessing', 'first-page': '205', 'author': 'Vallino', 'year': '1990'} / Frontiers in Bioprocessing by Vallino (1990)
{'key': '10.1016/S0167-7799(97)01067-6_bib4', 'series-title': 'Biological Regulation and Development', 'first-page': '99', 'author': 'Blum', 'year': '1982'} / Biological Regulation and Development by Blum (1982)
10.1002/(SICI)1097-0290(19960120)49:2<111::AID-BIT1>3.0.CO;2-T / Biotechnol. Bioeng. by Marx (1996)
10.1021/bp00029a006 / Biotechnol. Prog. by Zupke (1994)
{'key': '10.1016/S0167-7799(97)01067-6_bib7', 'series-title': 'Animal Cell Technology', 'first-page': '633', 'author': 'Bonarius', 'year': '1997'} / Animal Cell Technology by Bonarius (1997)
10.1002/bit.260210605 / Biotechnol. Bioeng. by Wang (1979)
10.1002/bit.260480617 / Biotechnol. Bioeng. by Van Gulik (1995)
10.1002/bit.260431122 / Biotechnol. Bioeng. by Xie (1994)
{'key': '10.1016/S0167-7799(97)01067-6_bib11', 'first-page': '65', 'volume': '27', 'author': 'Kacser', 'year': '1973'} by Kacser (1973)
10.1006/jtbi.1993.1202 / J. Theor. Biol. by Varma (1993)
10.1038/nbt0197-3 / Nat. Biotechnol. by Palsson (1997)
10.1016/S0022-5193(05)80595-8 / J. Theor. Biol. by Savinell (1992)
10.1016/S0022-5193(05)80161-4 / J. Theor. Biol. by Savinell (1992)
10.1002/bit.260380606 / Biotechnol. Bioeng. by Noorman (1991)
10.1002/bit.260410606 / Biotechnol. Bioeng. by Vallino (1993)
10.1128/AEM.62.10.3687-3696.1996 / Appl. Environ. Microbiol. by Sauer (1996)
10.1042/bj2380781 / Biochem. J. by Fell (1986)
10.1002/(SICI)1097-0290(19960505)50:3<299::AID-BIT9>3.0.CO;2-B / Biotechnol. Bioeng. by Bonarius (1996)
10.1002/(SICI)1097-0290(19960720)51:2<177::AID-BIT7>3.0.CO;2-G / Biotechnol Bioeng. by Pons (1996)
{'key': '10.1016/S0167-7799(97)01067-6_bib22', 'first-page': '341', 'volume': '1', 'author': 'Fell', 'year': '1990', 'journal-title': 'Comments Theor. Biol.'} / Comments Theor. Biol. by Fell (1990)
10.1099/00221287-136-3-405 / J. Gen. Microbiol. by Verduyn (1990)
{'key': '10.1016/S0167-7799(97)01067-6_bib24', 'first-page': '79', 'volume': '9', 'author': 'Schuster', 'year': '1993', 'journal-title': 'Comp. Appl. Biosci.'} / Comp. Appl. Biosci. by Schuster (1993)
10.1142/S0218339094000131 / J. Biol. Syst. by Schuster (1994)
10.1002/(SICI)1097-0290(19961005)52:1<129::AID-BIT13>3.0.CO;2-J / Biotechnol. Bioeng. by Liao (1996)
10.1042/bj0321615 / Biochem. J. by Dickens (1938)
10.1016/S0021-9258(18)71559-7 / J. Biol. Chem. by Larrabee (1989)
10.1002/bit.260440504 / Biotechnol. Bioeng. by Mancuso (1994)
10.1006/jtbi.1996.0181 / J. Theor. Biol. by Westerhoff (1996)

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 9:11 p.m.)
Deposited	4 years, 3 months ago (May 13, 2021, 5:36 p.m.)
Indexed	1 day, 9 hours ago (Sept. 4, 2025, 9:24 a.m.)
Issued	28 years, 1 month ago (Aug. 1, 1997)
Published	28 years, 1 month ago (Aug. 1, 1997)
Published Print	28 years, 1 month ago (Aug. 1, 1997)

Funders 0

None

BibTeX

@article{Bonarius_1997, title={Flux analysis of underdetermined metabolic networks: the quest for the missing constraints}, volume={15}, ISSN={0167-7799}, url={http://dx.doi.org/10.1016/s0167-7799(97)01067-6}, DOI={10.1016/s0167-7799(97)01067-6}, number={8}, journal={Trends in Biotechnology}, publisher={Elsevier BV}, author={Bonarius, Hendrik P.J. and Schmid, Georg and Tramper, Johannes}, year={1997}, month=aug, pages={308–314} }

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