DOI: 10.1016/s0167-5699(00)01649-2. Lipids on the move: phosphoinositide 3-kinases in leukocyte function

Lipids on the move: phosphoinositide 3-kinases in leukocyte function

10.1016/s0167-5699(00)01649-2

Crossref journal-article

Elsevier BV

Immunology Today (78)

Bibliography

Wymann, M. P., Sozzani, S., Altruda, F., Mantovani, A., & Hirsch, E. (2000). Lipids on the move: phosphoinositide 3-kinases in leukocyte function. Immunology Today, 21(6), 260â264.

Authors 5

Matthias P Wymann (first)
Silvano Sozzani (additional)
Fiorella Altruda (additional)
Alberto Mantovani (additional)
Emilio Hirsch (additional)

References 48 Referenced 97

10.1016/S1074-7613(00)80165-X / Immunity / Chemokines by Zlotnik (2000)
10.1038/334353a0 / Nature / An inositol tetrakisphosphate-containing phospholipid in activated neutrophils by Traynor-Kaplan (1988)
10.1016/S0021-9258(19)84884-6 / J. Biol. Chem. / Transient increase in phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol trisphosphate during activation of human neutrophils by Traynor-Kaplan (1989)
10.1126/science.7624799 / Science / Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase by Stoyanov (1995)
10.1016/S0092-8674(00)80187-7 / Cell / The G beta gamma sensitivity of a PI 3-K is dependent upon a tightly associated adaptor, p101 by Stephens (1997)
10.1074/jbc.274.24.17152 / J. Biol. Chem. / Characterizing the interactions between the two subunits of the p101/p110gamma phosphoinositide 3-kinase and their role in the activation of this enzyme by G beta gamma subunits by Krugmann (1999)
10.1074/jbc.274.41.29311 / J. Biol. Chem. / Roles of non-catalytic subunits in gbetagamma-induced activation of class I phosphoinositide 3-kinase isoforms beta and gamma by Maier (1999)
10.1016/S0024-3205(98)00106-4 / Life Sci. / Activation of PI 3-kinase by G protein betagamma subunits by Hazeki (1998)
10.1074/jbc.273.40.25987 / J. Biol. Chem. / The CC chemokine monocyte chemotactic peptide-1 activates both the class I p85/p110 phosphatidylinositol 3-kinase and the class II PI 3-K-C2alpha by Turner (1998)
10.1111/j.1749-6632.1997.tb46265.x / Ann. New York Acad. Sci. / G-protein coupled receptor-mediated activation of PI 3-kinase in neutrophils by Thelen (1997)
10.1074/jbc.271.11.6265 / J. Biol. Chem. / The CC chemokine monocyte chemotactic peptide-1 activates both the class I p85/p110 phosphatidylinositol 3-kinase and the class II PI 3-K-C2alpha by Zhang (1996)
10.1016/0167-5699(96)80618-9 / Immunol. Today / PI 3-kinase: a pivotal pathway in T-cell activation? by Ward (1996)
10.1084/jem.180.4.1427 / J. Exp. Med. / Fc receptor stimulation of phosphatidylinositol 3-kinase in natural killer cells is associated with protein kinase C-independent granule release and cell-mediated cytotoxicity by Bonnema (1994)
10.1016/0014-4827(87)90201-1 / Exp. Cell Res. / Inhibition of the phagocytosis-induced respiratory burst by the fungal metabolite wortmannin and some analogues by Baggiolini (1987)
10.1042/bj2960297 / Biochem. J. / Wortmannin is a potent phosphatidylinositol-3-kinase inhibitor by Arcaro (1993)
10.1016/S0021-9258(17)41900-4 / J. Biol. Chem. / Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase by Okada (1994)
10.1073/pnas.94.7.3052 / Proc. Natl. Acad. Sci. U. S. A. / Interleukin 8-stimulated phosphatidylinositol-3-kinase activity regulates the migration of human neutrophils independent of extracellular signal-regulated kinase and p38 mitogen-activated protein kinases by Knall (1997)
10.1016/S0014-2999(97)01169-2 / Eur. J. Pharmacol. / The phosphatidylinositol 3-kinase inhibitor wortmannin markedly reduces chemotactic peptide-induced locomotion and increases in cytoskeletal actin in human neutrophils by Niggli (1997)
10.1006/bbrc.1995.2903 / Biochem. Biophys. Res. Commun. / PI 3-kinase-dependent and independent chemotaxis of human neutrophil leukocytes by Thelen (1995)
10.1042/bj3290121 / Biochem. J. / Comparison of the roles of mitogen-activated protein kinase kinase and phosphatidylinositol 3-kinase signal transduction in neutrophil effector function by Coffer (1998)
10.1242/jcs.111.14.1921 / J. Cell Sci. / Chemotaxis of chinese hamster ovary cells expressing the human neutrophil formyl peptide receptor by Miettinen (1998)
10.4049/jimmunol.163.11.5954 / J. Immunol. / The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes by Sotsios (1999)
10.4049/jimmunol.163.7.4001 / J. Immunol. / Involvement of phosphatidylinositol 3-kinase in stromal cell-derived factor-1 alpha-induced lymphocyte polarization and chemotaxis by Vicente-Manzanares (1999)
10.1182/blood.V94.11.3658 / Blood / Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells by Burger (1999)
10.4049/jimmunol.155.5.2437 / J. Immunol. / RANTES-activated human T lymphocytes. A role for phosphoinositide 3-kinase by Turner (1995)
10.4049/jimmunol.162.6.3249 / J. Immunol. / Recruitment of pleckstrin and phosphoinositide 3-kinase gamma into the cell membranes, and their association with G beta gamma after activation of NK cells with chemokines by al-Aoukaty (1999)
10.1038/9045 / Nat. Cell Biol. / Distinct PI(3)Ks mediate mitogenic signalling and cell migration in macrophages by Vanhaesebroeck (1999)
10.1126/science.287.5455.1049 / Science / Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation by Hirsch (2000)
10.1126/science.287.5455.1046 / Science / Roles of PLC-β2 and-β3 and PI 3-Kgamma in chemoattractant-mediated signal transduction by Li (2000)
10.1126/science.287.5455.1040 / Science / Function of PI 3-Kgamma in thymocyte development, T cell activation, and neutrophil migration by Sasaki (2000)
10.1042/0264-6021:3460561 / Biochem. J. / The PI 3-K-PDK1 connection by Vanhaesebroeck (2000)
{'key': '10.1016/S0167-5699(00)01649-2_BIB32', 'first-page': '447', 'article-title': 'Retinoic acid induces selective expression of phosphoinositide 3-kinase gamma in myelomonocytic U937 cells', 'volume': '10', 'author': 'Baier', 'year': '1999', 'journal-title': 'Cell Growth Differ.'} / Cell Growth Differ. / Retinoic acid induces selective expression of phosphoinositide 3-kinase gamma in myelomonocytic U937 cells by Baier (1999)
10.1182/blood.V94.10.3281.422k37_3281_3288 / Blood / Of man and mouse by Etzioni (1999)
10.4049/jimmunol.151.3.1571 / J. Immunol. / Gene targeting yields a CD18-mutant mouse for study of inflammation by Wilson (1993)
10.1159/000020593 / Exp. Nephrol. / Leukocyte-endothelial cell interactions – lessons from knockout mice by Rosenkranz (1999)
10.1016/S0092-8674(00)81032-6 / Cell / Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins by Frenette (1996)
10.1016/S1074-7613(00)80019-9 / Immunity / Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense by Roberts (1999)
10.1126/science.279.5350.509 / Science / G proteins and small GTPases by Hall (1998)
10.1128/MCB.18.8.4744 / Mol. Cell. Biol. / Cytoskeletal reorganization by G protein-coupled receptors is dependent on hosphoinositide 3-kinase γ, a Rac guanosine exchange factor, and Rac by Ma (1998)
10.1093/emboj/17.18.5374 / EMBO J. / Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast by Isakoff (1998)
10.1126/science.287.5455.1037 / Science / Polarization of chemoattractant receptor signaling during neutrophil chemotaxis by Servant (2000)
10.1093/emboj/18.8.2092 / EMBO J. / Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium by Meili (1999)
10.1074/jbc.271.11.6010 / J. Biol. Chem. / Inhibition of monocyte chemotaxis to C-C chemokines by antisense oligonucleotide for cytosolic phospholipase A2 by Locati (1996)
10.1182/blood.V94.6.1890 / Blood / Macrophage-derived chemokine is localized to thymic medullary epithelial cells and is a chemoattractant for CD3(+), CD4(+), CD8(low) thymocytes by Chantry (1999)
10.1016/S0167-5699(99)01469-3 / Immunol. Today / The chemokine system by Mantovani (1999)
10.1016/S0960-9822(06)00239-9 / Curr. Biol. / Signalling enzymes by Braselmann (1997)
10.1038/46319 / Nature / Structural insights into phosphoinositide 3-kinase catalysis and signalling by Walker (1999)
10.1016/S0005-2760(98)00139-8 / Biochim. Biophys. Acta / Structure and function of phosphoinositide 3-kinases by Wymann (1998)

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 10:42 p.m.)
Deposited	2 years, 4 months ago (April 17, 2023, 5:46 a.m.)
Indexed	2 months, 2 weeks ago (June 10, 2025, 1:47 p.m.)
Issued	25 years, 2 months ago (June 1, 2000)
Published	25 years, 2 months ago (June 1, 2000)
Published Print	25 years, 2 months ago (June 1, 2000)

Funders 0

None

BibTeX

@article{Wymann_2000, title={Lipids on the move: phosphoinositide 3-kinases in leukocyte function}, volume={21}, ISSN={0167-5699}, url={http://dx.doi.org/10.1016/s0167-5699(00)01649-2}, DOI={10.1016/s0167-5699(00)01649-2}, number={6}, journal={Immunology Today}, publisher={Elsevier BV}, author={Wymann, Matthias P and Sozzani, Silvano and Altruda, Fiorella and Mantovani, Alberto and Hirsch, Emilio}, year={2000}, month=jun, pages={260–264} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        6,
        10
      ]
    ],
    "date-time": "2025-06-10T17:47:58Z",
    "timestamp": 1749577678280
  },
  "reference-count": 48,
  "publisher": "Elsevier BV",
  "issue": "6",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2000,
            6,
            1
          ]
        ],
        "date-time": "2000-06-01T00:00:00Z",
        "timestamp": 959817600000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2000,
        6
      ]
    ]
  },
  "DOI": "10.1016/s0167-5699(00)01649-2",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        7,
        26
      ]
    ],
    "date-time": "2002-07-26T02:42:44Z",
    "timestamp": 1027651364000
  },
  "page": "260-264",
  "source": "Crossref",
  "is-referenced-by-count": 97,
  "title": "Lipids on the move: phosphoinositide 3-kinases in leukocyte function",
  "prefix": "10.1016",
  "volume": "21",
  "author": [
    {
      "given": "Matthias P",
      "family": "Wymann",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Silvano",
      "family": "Sozzani",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Fiorella",
      "family": "Altruda",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Alberto",
      "family": "Mantovani",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Emilio",
      "family": "Hirsch",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB1",
      "doi-asserted-by": "crossref",
      "first-page": "121",
      "DOI": "10.1016/S1074-7613(00)80165-X",
      "article-title": "Chemokines",
      "volume": "12",
      "author": "Zlotnik",
      "year": "2000",
      "journal-title": "Immunity"
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "353",
      "DOI": "10.1038/334353a0",
      "article-title": "An inositol tetrakisphosphate-containing phospholipid in activated neutrophils",
      "volume": "334",
      "author": "Traynor-Kaplan",
      "year": "1988",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "15668",
      "DOI": "10.1016/S0021-9258(19)84884-6",
      "article-title": "Transient increase in phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol trisphosphate during activation of human neutrophils",
      "volume": "264",
      "author": "Traynor-Kaplan",
      "year": "1989",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB4",
      "doi-asserted-by": "crossref",
      "first-page": "690",
      "DOI": "10.1126/science.7624799",
      "article-title": "Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase",
      "volume": "269",
      "author": "Stoyanov",
      "year": "1995",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB5",
      "doi-asserted-by": "crossref",
      "first-page": "105",
      "DOI": "10.1016/S0092-8674(00)80187-7",
      "article-title": "The G beta gamma sensitivity of a PI 3-K is dependent upon a tightly associated adaptor, p101",
      "volume": "89",
      "author": "Stephens",
      "year": "1997",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "17152",
      "DOI": "10.1074/jbc.274.24.17152",
      "article-title": "Characterizing the interactions between the two subunits of the p101/p110gamma phosphoinositide 3-kinase and their role in the activation of this enzyme by G beta gamma subunits",
      "volume": "274",
      "author": "Krugmann",
      "year": "1999",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "29311",
      "DOI": "10.1074/jbc.274.41.29311",
      "article-title": "Roles of non-catalytic subunits in gbetagamma-induced activation of class I phosphoinositide 3-kinase isoforms beta and gamma",
      "volume": "274",
      "author": "Maier",
      "year": "1999",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB8",
      "doi-asserted-by": "crossref",
      "first-page": "1555",
      "DOI": "10.1016/S0024-3205(98)00106-4",
      "article-title": "Activation of PI 3-kinase by G protein betagamma subunits",
      "volume": "62",
      "author": "Hazeki",
      "year": "1998",
      "journal-title": "Life Sci."
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "25987",
      "DOI": "10.1074/jbc.273.40.25987",
      "article-title": "The CC chemokine monocyte chemotactic peptide-1 activates both the class I p85/p110 phosphatidylinositol 3-kinase and the class II PI 3-K-C2alpha",
      "volume": "273",
      "author": "Turner",
      "year": "1998",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "368",
      "DOI": "10.1111/j.1749-6632.1997.tb46265.x",
      "article-title": "G-protein coupled receptor-mediated activation of PI 3-kinase in neutrophils",
      "volume": "832",
      "author": "Thelen",
      "year": "1997",
      "journal-title": "Ann. New York Acad. Sci."
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB11",
      "doi-asserted-by": "crossref",
      "first-page": "6265",
      "DOI": "10.1074/jbc.271.11.6265",
      "article-title": "The CC chemokine monocyte chemotactic peptide-1 activates both the class I p85/p110 phosphatidylinositol 3-kinase and the class II PI 3-K-C2alpha",
      "volume": "271",
      "author": "Zhang",
      "year": "1996",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "187",
      "DOI": "10.1016/0167-5699(96)80618-9",
      "article-title": "PI 3-kinase: a pivotal pathway in T-cell activation?",
      "volume": "17",
      "author": "Ward",
      "year": "1996",
      "journal-title": "Immunol. Today"
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "1427",
      "DOI": "10.1084/jem.180.4.1427",
      "article-title": "Fc receptor stimulation of phosphatidylinositol 3-kinase in natural killer cells is associated with protein kinase C-independent granule release and cell-mediated cytotoxicity",
      "volume": "180",
      "author": "Bonnema",
      "year": "1994",
      "journal-title": "J. Exp. Med."
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "408",
      "DOI": "10.1016/0014-4827(87)90201-1",
      "article-title": "Inhibition of the phagocytosis-induced respiratory burst by the fungal metabolite wortmannin and some analogues",
      "volume": "169",
      "author": "Baggiolini",
      "year": "1987",
      "journal-title": "Exp. Cell Res."
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "297",
      "DOI": "10.1042/bj2960297",
      "article-title": "Wortmannin is a potent phosphatidylinositol-3-kinase inhibitor",
      "volume": "296",
      "author": "Arcaro",
      "year": "1993",
      "journal-title": "Biochem. J."
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "3563",
      "DOI": "10.1016/S0021-9258(17)41900-4",
      "article-title": "Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase",
      "volume": "269",
      "author": "Okada",
      "year": "1994",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "3052",
      "DOI": "10.1073/pnas.94.7.3052",
      "article-title": "Interleukin 8-stimulated phosphatidylinositol-3-kinase activity regulates the migration of human neutrophils independent of extracellular signal-regulated kinase and p38 mitogen-activated protein kinases",
      "volume": "94",
      "author": "Knall",
      "year": "1997",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "43",
      "DOI": "10.1016/S0014-2999(97)01169-2",
      "article-title": "The phosphatidylinositol 3-kinase inhibitor wortmannin markedly reduces chemotactic peptide-induced locomotion and increases in cytoskeletal actin in human neutrophils",
      "volume": "335",
      "author": "Niggli",
      "year": "1997",
      "journal-title": "Eur. J. Pharmacol."
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "1255",
      "DOI": "10.1006/bbrc.1995.2903",
      "article-title": "PI 3-kinase-dependent and independent chemotaxis of human neutrophil leukocytes",
      "volume": "217",
      "author": "Thelen",
      "year": "1995",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "121",
      "DOI": "10.1042/bj3290121",
      "article-title": "Comparison of the roles of mitogen-activated protein kinase kinase and phosphatidylinositol 3-kinase signal transduction in neutrophil effector function",
      "volume": "329",
      "author": "Coffer",
      "year": "1998",
      "journal-title": "Biochem. J."
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB21",
      "doi-asserted-by": "crossref",
      "first-page": "1921",
      "DOI": "10.1242/jcs.111.14.1921",
      "article-title": "Chemotaxis of chinese hamster ovary cells expressing the human neutrophil formyl peptide receptor",
      "volume": "111",
      "author": "Miettinen",
      "year": "1998",
      "journal-title": "J. Cell Sci."
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "5954",
      "DOI": "10.4049/jimmunol.163.11.5954",
      "article-title": "The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes",
      "volume": "163",
      "author": "Sotsios",
      "year": "1999",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "4001",
      "DOI": "10.4049/jimmunol.163.7.4001",
      "article-title": "Involvement of phosphatidylinositol 3-kinase in stromal cell-derived factor-1 alpha-induced lymphocyte polarization and chemotaxis",
      "volume": "163",
      "author": "Vicente-Manzanares",
      "year": "1999",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "3658",
      "DOI": "10.1182/blood.V94.11.3658",
      "article-title": "Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells",
      "volume": "94",
      "author": "Burger",
      "year": "1999",
      "journal-title": "Blood"
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "2437",
      "DOI": "10.4049/jimmunol.155.5.2437",
      "article-title": "RANTES-activated human T lymphocytes. A role for phosphoinositide 3-kinase",
      "volume": "155",
      "author": "Turner",
      "year": "1995",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB26",
      "doi-asserted-by": "crossref",
      "first-page": "3249",
      "DOI": "10.4049/jimmunol.162.6.3249",
      "article-title": "Recruitment of pleckstrin and phosphoinositide 3-kinase gamma into the cell membranes, and their association with G beta gamma after activation of NK cells with chemokines",
      "volume": "162",
      "author": "al-Aoukaty",
      "year": "1999",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB27",
      "doi-asserted-by": "crossref",
      "first-page": "69",
      "DOI": "10.1038/9045",
      "article-title": "Distinct PI(3)Ks mediate mitogenic signalling and cell migration in macrophages",
      "volume": "1",
      "author": "Vanhaesebroeck",
      "year": "1999",
      "journal-title": "Nat. Cell Biol."
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "1049",
      "DOI": "10.1126/science.287.5455.1049",
      "article-title": "Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation",
      "volume": "287",
      "author": "Hirsch",
      "year": "2000",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "1046",
      "DOI": "10.1126/science.287.5455.1046",
      "article-title": "Roles of PLC-\u03b22 and-\u03b23 and PI 3-Kgamma in chemoattractant-mediated signal transduction",
      "volume": "287",
      "author": "Li",
      "year": "2000",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "1040",
      "DOI": "10.1126/science.287.5455.1040",
      "article-title": "Function of PI 3-Kgamma in thymocyte development, T cell activation, and neutrophil migration",
      "volume": "287",
      "author": "Sasaki",
      "year": "2000",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "561",
      "DOI": "10.1042/0264-6021:3460561",
      "article-title": "The PI 3-K-PDK1 connection",
      "volume": "346",
      "author": "Vanhaesebroeck",
      "year": "2000",
      "journal-title": "Biochem. J."
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB32",
      "first-page": "447",
      "article-title": "Retinoic acid induces selective expression of phosphoinositide 3-kinase gamma in myelomonocytic U937 cells",
      "volume": "10",
      "author": "Baier",
      "year": "1999",
      "journal-title": "Cell Growth Differ."
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "3281",
      "DOI": "10.1182/blood.V94.10.3281.422k37_3281_3288",
      "article-title": "Of man and mouse",
      "volume": "94",
      "author": "Etzioni",
      "year": "1999",
      "journal-title": "Blood"
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "1571",
      "DOI": "10.4049/jimmunol.151.3.1571",
      "article-title": "Gene targeting yields a CD18-mutant mouse for study of inflammation",
      "volume": "151",
      "author": "Wilson",
      "year": "1993",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "125",
      "DOI": "10.1159/000020593",
      "article-title": "Leukocyte-endothelial cell interactions \u2013 lessons from knockout mice",
      "volume": "7",
      "author": "Rosenkranz",
      "year": "1999",
      "journal-title": "Exp. Nephrol."
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB36",
      "doi-asserted-by": "crossref",
      "first-page": "563",
      "DOI": "10.1016/S0092-8674(00)81032-6",
      "article-title": "Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins",
      "volume": "84",
      "author": "Frenette",
      "year": "1996",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB37",
      "doi-asserted-by": "crossref",
      "first-page": "183",
      "DOI": "10.1016/S1074-7613(00)80019-9",
      "article-title": "Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense",
      "volume": "10",
      "author": "Roberts",
      "year": "1999",
      "journal-title": "Immunity"
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB38",
      "doi-asserted-by": "crossref",
      "first-page": "509",
      "DOI": "10.1126/science.279.5350.509",
      "article-title": "G proteins and small GTPases",
      "volume": "279",
      "author": "Hall",
      "year": "1998",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB39",
      "doi-asserted-by": "crossref",
      "first-page": "4744",
      "DOI": "10.1128/MCB.18.8.4744",
      "article-title": "Cytoskeletal reorganization by G protein-coupled receptors is dependent on hosphoinositide 3-kinase \u03b3, a Rac guanosine exchange factor, and Rac",
      "volume": "18",
      "author": "Ma",
      "year": "1998",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "5374",
      "DOI": "10.1093/emboj/17.18.5374",
      "article-title": "Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast",
      "volume": "17",
      "author": "Isakoff",
      "year": "1998",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB41",
      "doi-asserted-by": "crossref",
      "first-page": "1037",
      "DOI": "10.1126/science.287.5455.1037",
      "article-title": "Polarization of chemoattractant receptor signaling during neutrophil chemotaxis",
      "volume": "287",
      "author": "Servant",
      "year": "2000",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB42",
      "doi-asserted-by": "crossref",
      "first-page": "2092",
      "DOI": "10.1093/emboj/18.8.2092",
      "article-title": "Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium",
      "volume": "18",
      "author": "Meili",
      "year": "1999",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB43",
      "doi-asserted-by": "crossref",
      "first-page": "6010",
      "DOI": "10.1074/jbc.271.11.6010",
      "article-title": "Inhibition of monocyte chemotaxis to C-C chemokines by antisense oligonucleotide for cytosolic phospholipase A2",
      "volume": "271",
      "author": "Locati",
      "year": "1996",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB44",
      "doi-asserted-by": "crossref",
      "first-page": "1890",
      "DOI": "10.1182/blood.V94.6.1890",
      "article-title": "Macrophage-derived chemokine is localized to thymic medullary epithelial cells and is a chemoattractant for CD3(+), CD4(+), CD8(low) thymocytes",
      "volume": "94",
      "author": "Chantry",
      "year": "1999",
      "journal-title": "Blood"
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB45",
      "doi-asserted-by": "crossref",
      "first-page": "254",
      "DOI": "10.1016/S0167-5699(99)01469-3",
      "article-title": "The chemokine system",
      "volume": "20",
      "author": "Mantovani",
      "year": "1999",
      "journal-title": "Immunol. Today"
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB46",
      "doi-asserted-by": "crossref",
      "first-page": "R470",
      "DOI": "10.1016/S0960-9822(06)00239-9",
      "article-title": "Signalling enzymes",
      "volume": "7",
      "author": "Braselmann",
      "year": "1997",
      "journal-title": "Curr. Biol."
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB47",
      "doi-asserted-by": "crossref",
      "first-page": "313",
      "DOI": "10.1038/46319",
      "article-title": "Structural insights into phosphoinositide 3-kinase catalysis and signalling",
      "volume": "402",
      "author": "Walker",
      "year": "1999",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0167-5699(00)01649-2_BIB48",
      "doi-asserted-by": "crossref",
      "first-page": "127",
      "DOI": "10.1016/S0005-2760(98)00139-8",
      "article-title": "Structure and function of phosphoinositide 3-kinases",
      "volume": "1436",
      "author": "Wymann",
      "year": "1998",
      "journal-title": "Biochim. Biophys. Acta"
    }
  ],
  "container-title": "Immunology Today",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0167569900016492?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0167569900016492?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        4,
        17
      ]
    ],
    "date-time": "2023-04-17T09:46:58Z",
    "timestamp": 1681724818000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0167569900016492"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2000,
        6
      ]
    ]
  },
  "references-count": 48,
  "journal-issue": {
    "issue": "6",
    "published-print": {
      "date-parts": [
        [
          2000,
          6
        ]
      ]
    }
  },
  "alternative-id": [
    "S0167569900016492"
  ],
  "URL": "http://dx.doi.org/10.1016/S0167-5699(00)01649-2",
  "relation": {},
  "ISSN": [
    "0167-5699"
  ],
  "subject": [],
  "container-title-short": "Immunology Today",
  "published": {
    "date-parts": [
      [
        2000,
        6
      ]
    ]
  }
}