DOI: 10.1016/s0167-4781(98)00274-7. Stabilization of poly-l-lysine/DNA polyplexes for in vivo gene delivery to the liver

Stabilization of poly-l-lysine/DNA polyplexes for in vivo gene delivery to the liver

10.1016/s0167-4781(98)00274-7

Crossref journal-article

Elsevier BV

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression (78)

Bibliography

Kwoh, D. Y., Coffin, C. C., Lollo, C. P., Jovenal, J., Banaszczyk, M. G., Mullen, P., Phillips, A., Amini, A., Fabrycki, J., Bartholomew, R. M., Brostoff, S. W., & Carlo, D. J. (1999). Stabilization of poly-l-lysine/DNA polyplexes for in vivo gene delivery to the liver. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1444(2), 171â190.

Authors 12

Deborah Y. Kwoh (first)
Christopher C. Coffin (additional)
Charles P. Lollo (additional)
Jocelyn Jovenal (additional)
Mariusz G. Banaszczyk (additional)
Patricia Mullen (additional)
Alison Phillips (additional)
Arjang Amini (additional)
Joanne Fabrycki (additional)
Richard M. Bartholomew (additional)
Steven W. Brostoff (additional)
Dennis J. Carlo (additional)

References 63 Referenced 239

{'key': '10.1016/S0167-4781(98)00274-7_BIB1', 'first-page': '542', 'article-title': 'Direct gene transfer to mouse melanoma by intratumor injection of free DNA', 'volume': '3', 'author': 'Yang', 'year': '1996', 'journal-title': 'Gene Ther.'} / Gene Ther. / Direct gene transfer to mouse melanoma by intratumor injection of free DNA by Yang (1996)
10.1146/annurev.mi.49.100195.004111 / Annu. Rev. Microbiol. / Viral vectors in gene therapy by Smith (1995)
10.1016/S0167-7799(97)01036-6 / Trends Biotechnol. / Biomedical applications of nanotechnology – implications for drug targeting and gene therapy by Davis (1997)
10.1126/science.1690918 / Science / Direct gene transfer into mouse muscle in vivo by Wolff (1990)
{'key': '10.1016/S0167-4781(98)00274-7_BIB5', 'first-page': '239', 'article-title': 'Liposomes as carriers of DNA', 'volume': '6', 'author': 'Nicolau', 'year': '1989', 'journal-title': 'Crit. Rev. Ther. Drug Carrier Syst.'} / Crit. Rev. Ther. Drug Carrier Syst. / Liposomes as carriers of DNA by Nicolau (1989)
10.1038/scientificamerican0697-102 / Sci. Am. / Nonviral strategies for gene therapy by Felgner (1997)
10.1089/hum.1997.8.5-511 / Hum. Gene Ther. / Nomenclature for synthetic gene delivery systems by Felgner (1997)
10.1073/pnas.87.9.3410 / Proc. Natl. Acad. Sci. USA / Transferrin–polycation conjugates as carriers for DNA uptake into cells by Wagner (1990)
10.1021/bc00010a006 / Bioconjug. Chem. / DNA-binding transferrin conjugates as functional gene-delivery agents: synthesis by linkage of polylysine or ethidium homodimer to the transferrin carbohydrate moiety by Wagner (1991)
10.1021/bc00023a012 / Bioconjug. Chem. / Polyamidoamine cascade polymers mediate efficient transfection of cells in culture by Haensler (1993)
10.1074/jbc.271.18.10560 / J. Biol. Chem. / Target cell-specific DNA transfer mediated by a chimeric multidomain protein – novel non-viral gene delivery system by Fominaya (1996)
10.1089/hum.1996.7.12-1395 / Hum. Gene Ther. / Gene transfer into mammalian cells using histone-condensed plasmid DNA by Fritz (1996)
{'key': '10.1016/S0167-4781(98)00274-7_BIB13', 'first-page': '448', 'article-title': 'A novel DNA–peptide complex for efficient gene transfer and expression in mammalian cells', 'volume': '3', 'author': 'Gottschalk', 'year': '1996', 'journal-title': 'Gene Ther.'} / Gene Ther. / A novel DNA–peptide complex for efficient gene transfer and expression in mammalian cells by Gottschalk (1996)
10.1074/jbc.271.52.33647 / J. Biol. Chem. / Targeting DNA to cells with basic fibroblast growth factor (FGF2) by Sosnowski (1996)
10.1073/pnas.88.19.8850 / Proc. Natl. Acad. Sci. USA / Adenovirus enhancement of transferrin-polylysine-mediated gene delivery by Curiel (1991)
{'key': '10.1016/S0167-4781(98)00274-7_BIB16', 'first-page': 'S31', 'article-title': 'Nonviral gene delivery: vehicle and delivery characterization', 'volume': '8', 'author': 'Lollo', 'year': '1997', 'journal-title': 'Blood Coagul. Fibrinol.'} / Blood Coagul. Fibrinol. / Nonviral gene delivery: vehicle and delivery characterization by Lollo (1997)
10.1016/S0021-9258(18)68081-0 / J. Biol. Chem. / Receptor-mediated gene delivery and expression in vivo by Wu (1988)
10.1021/bc00018a012 / Bioconjug. Chem. / Gene transfer into hepatocytes using asialoglycoprotein receptor mediated endocytosis of DNA complexed with an artificial tetra-antennary galactose ligand by Plank (1992)
{'key': '10.1016/S0167-4781(98)00274-7_BIB19', 'first-page': '47', 'article-title': 'Uptake of liposomes by rat and mouse heptocytes and Kupffer cells', 'volume': '47', 'author': 'Scherphof', 'year': '1983', 'journal-title': 'Biol. Cell'} / Biol. Cell / Uptake of liposomes by rat and mouse heptocytes and Kupffer cells by Scherphof (1983)
10.1002/hep.1840050427 / Hepatology / The liver sieve: considerations concerning the structure and function of endothelial fenestrae, the sinusoidal wall and the space of Disse by Wisse (1985)
10.1615/CritRevTherDrugCarrierSyst.v14.i2.20 / Crit. Rev. Ther. Drug Carrier Syst. / Nonviral vectors for in vivo gene delivery: physicochemical and pharmacokinetic considerations by Mahato (1997)
10.1089/hum.1995.6.9-1129 / Hum. Gene Ther. / Nonviral gene therapy: the promise of genes as pharmaceutical products by Ledley (1995)
10.1023/A:1016420102549 / Pharm. Res. / Pharmaceutical approach to somatic gene therapy by Ledley (1996)
10.1016/S0169-409X(97)00031-8 / Adv. Drug Deliv. Rev. / Toward development of a non-viral gene therapeutic by Smith (1997)
10.1089/hum.1996.7.12-1437 / Hum. Gene Ther. / Activation of the complement system by synthetic DNA complexes: a potential barrier for intravenous gene delivery by Plank (1996)
{'key': '10.1016/S0167-4781(98)00274-7_BIB26', 'first-page': '269', 'article-title': 'Atomic force microscopic analysis of the influence of the molecular weight of poly(l)lysine on the size of polyelectrolyte complexes formed with DNA', 'volume': '3', 'author': 'Wolfert', 'year': '1996', 'journal-title': 'Gene Ther.'} / Gene Ther. / Atomic force microscopic analysis of the influence of the molecular weight of poly(l)lysine on the size of polyelectrolyte complexes formed with DNA by Wolfert (1996)
10.1016/S0021-9258(18)71447-6 / J. Biol. Chem. / Targeting genes: delivery and persistent expression of a foreign gene driven by mammalian regulatory elements in vivo by Wu (1989)
10.1111/j.1432-1033.1994.tb20049.x / Eur. J. Biochem. / An evaluation of receptor-mediated gene transfer using synthetic DNA–ligand complexes by Perales (1994)
10.1089/hum.1994.5.9-1095 / Hum. Gene Ther. / Overexpression of human methylmalonyl CoA mutase in mice after in vivo gene transfer with asialoglycoprotein/polylysine/DNA complexes by Stankovics (1994)
K.V. Shah, Polyomaviruses, in: B.N. Fields (Ed.), Virology, Raven Press, New York, 1990, pp. 1609–1623.
10.1002/bip.360300514 / Biopolymers / Condensation of DNA by trivalent cations. 1. Effects of DNA length and topology on the size and shape of condensed particles by Arscott (1990)
10.1093/nar/25.11.2221 / Nucleic Acids Res. / AFM analysis of DNA–protamine complexes bound to mica by Allen (1997)
10.1002/bip.360311305 / Biopolymers / Condensation of DNA by multivalent cations: considerations on mechanism by Bloomfield (1991)
10.1016/S0959-440X(96)80052-2 / Curr. Opin. Struct. Biol. / DNA condensation by Bloomfield (1996)
10.1042/bst0190496 / Biochem. Soc. Trans. / Light scattering studies on DNA condensation by Bloomfield (1990)
10.1074/jbc.272.11.7398 / J. Biol. Chem. / Biochemical and functional characterization of DNA complexes capable of targeting genes to hepatocytes via the asialoglycoprotein receptor by Perales (1997)
10.1073/pnas.88.10.4255 / Proc. Natl. Acad. Sci. USA / Transferrin–polycation–DNA complexes: the effect of polycations on the structure of the complex and DNA delivery to cells by Wagner (1991)
10.1016/S0021-9258(18)69851-5 / J. Biol. Chem. / The thiobarbituric acid assay of sialic acids by Warren (1959)
10.1093/oxfordjournals.jbchem.a131830 / J. Biochem. / Distribution of neuraminidase in Arthobacter and its purification by affinity chromatography by Uchida (1977)
10.1021/bc00028a004 / Bioconjug. Chem. / Preparation of asialoorosomucoid-polylysine conjugates by McKee (1994)
10.1021/bc00030a017 / Bioconjug. Chem. / Targeted delivery of DNA using YEE(GalNAcAH)3, a synthetic glycopeptide ligand for the asialoglycoprotein receptor by Merwin (1994)
10.1021/ma00218a005 / Macromolecules / Proton NMR characterization of poly(ethylene glycols) and derivatives by Dust (1990)
J. Sambrook, E.F. Fritsch, T. Maniatis, Molecular Cloning: A Laboratory Manual, 2nd edn., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989.
10.1074/jbc.271.14.8481 / J. Biol. Chem. / Folate-targeted, anionic liposome-entrapped polylysine-condensed DNA for tumor cell-specific gene transfer by Lee (1996)
10.1038/sj.gt.3300454 / Gene Ther. / The influence of polymer structure on the interactions of cationic polymers with DNA and morphology of the resulting complexes by Tang (1997)
10.1016/S0005-2736(96)00171-X / Biochim. Biophys. Acta / Interaction of surfactants with DNA. Role of hydrophobicity and surface charge on intercalation and DNA melting by Bhattacharya (1997)
M.A. Hayat and S.E. MIller, Negative Staining, McGraw-Hill, New York, 1990.
10.1016/S0169-409X(96)00456-5 / Adv. Drug Deliv. Rev. / Stealth® liposomes: from theory to product by Ceh (1997)
10.1089/hum.1995.6.5-553 / Hum. Gene Ther. / Cancer gene therapy using plasmid DNA: pharmacokinetic study of DNA following injection in mice by Lew (1995)
10.1002/bip.360311210 / Biopolymers / DNA interpolyelectrolyte complexes as a tool for efficient cell transformation by Kabanov (1991)
10.1089/hum.1996.7.14-1701 / Hum. Gene Ther. / Detailed analysis of structures and formulations of cationic lipids for efficient gene transfer to the lung by Lee (1996)
10.1073/pnas.89.17.7934 / Proc. Natl. Acad. Sci. USA / Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin–polylysine–DNA complexes: toward a synthetic virus-like gene-transfer vehicle by Wagner (1992)
10.1073/pnas.89.13.6099 / Proc. Natl. Acad. Sci. USA / Coupling of adenovirus to transferrin–polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes by Wagner (1992)
10.1016/S0021-9258(18)99963-1 / J. Biol. Chem. / The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems by Plank (1994)
10.1016/S0021-9258(18)82119-6 / J. Biol. Chem. / Fate of DNA targeted to the liver by asialoglycoprotein receptor-mediated endocytosis in vivo. Prolonged persistence in cytoplasmic vesicles after partial hepatectomy by Chowdhury (1993)
10.1016/S0021-9258(18)98689-8 / J. Biol. Chem. / Receptor-mediated gene delivery in vivo. Partial correction of genetic analbuminemia in Nagase rats by Wu (1991)
{'key': '10.1016/S0167-4781(98)00274-7_BIB57', 'first-page': '847', 'article-title': 'In vivo transfection of hepatitis C virus complementary DNA into rodent liver by asialoglycoprotein receptor mediated gene delivery', 'volume': '22', 'author': 'Yamamoto', 'year': '1995', 'journal-title': 'Hepatology'} / Hepatology / In vivo transfection of hepatitis C virus complementary DNA into rodent liver by asialoglycoprotein receptor mediated gene delivery by Yamamoto (1995)
10.1089/hum.1996.7.17-2123 / Hum. Gene Ther. / Characterization of vectors for gene therapy formed by self-assembly of DNA with synthetic block co-polymers by Wolfert (1996)
10.1016/0005-2736(94)90038-8 / Biochim. Biophys. Acta / Effect of liposome size on the circulation time and intraorgan distribution of amphipathic poly(ethylene glycol)-containing liposomes by Litzinger (1994)
10.1016/S0005-2760(96)00157-9 / Biochim. Biophys. Acta / Serum–liposome interaction is an oxygen-dependent process by Foradada (1997)
P.C. Hiemenz, Principles of Colloid and Surface Chemistry, 2nd edn., Marcel Dekker, New York, NY, 1986.
10.1016/S0304-4165(98)00004-X / Biochim. Biophys. Acta / Novel vectors for gene delivery formed by self-assembly of DNA with poly(l-lysine) grafted with hydrophilic polymers by Toncheva (1998)
10.1016/0005-2736(91)90201-I / Biochim. Biophys. Acta / Pharmacokinetics of stealth versus conventional liposomes: effect of dose by Allen (1991)

Dates

Type	When
Created	23 years ago (July 25, 2002, 7:22 a.m.)
Deposited	4 years, 3 months ago (May 4, 2021, 9:45 p.m.)
Indexed	3 weeks ago (Aug. 2, 2025, 12:12 a.m.)
Issued	26 years, 6 months ago (Feb. 1, 1999)
Published	26 years, 6 months ago (Feb. 1, 1999)
Published Print	26 years, 6 months ago (Feb. 1, 1999)

Funders 0

None

BibTeX

@article{Kwoh_1999, title={Stabilization of poly-l-lysine/DNA polyplexes for in vivo gene delivery to the liver}, volume={1444}, ISSN={0167-4781}, url={http://dx.doi.org/10.1016/s0167-4781(98)00274-7}, DOI={10.1016/s0167-4781(98)00274-7}, number={2}, journal={Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression}, publisher={Elsevier BV}, author={Kwoh, Deborah Y. and Coffin, Christopher C. and Lollo, Charles P. and Jovenal, Jocelyn and Banaszczyk, Mariusz G. and Mullen, Patricia and Phillips, Alison and Amini, Arjang and Fabrycki, Joanne and Bartholomew, Richard M. and Brostoff, Steven W. and Carlo, Dennis J.}, year={1999}, month=feb, pages={171–190} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        2
      ]
    ],
    "date-time": "2025-08-02T04:12:44Z",
    "timestamp": 1754107964685
  },
  "reference-count": 63,
  "publisher": "Elsevier BV",
  "issue": "2",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1999,
            2,
            1
          ]
        ],
        "date-time": "1999-02-01T00:00:00Z",
        "timestamp": 917827200000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1999,
        2
      ]
    ]
  },
  "DOI": "10.1016/s0167-4781(98)00274-7",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        7,
        25
      ]
    ],
    "date-time": "2002-07-25T11:22:33Z",
    "timestamp": 1027596153000
  },
  "page": "171-190",
  "source": "Crossref",
  "is-referenced-by-count": 239,
  "title": "Stabilization of poly-l-lysine/DNA polyplexes for in vivo gene delivery to the liver",
  "prefix": "10.1016",
  "volume": "1444",
  "author": [
    {
      "given": "Deborah Y.",
      "family": "Kwoh",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Christopher C.",
      "family": "Coffin",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Charles P.",
      "family": "Lollo",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Jocelyn",
      "family": "Jovenal",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Mariusz G.",
      "family": "Banaszczyk",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Patricia",
      "family": "Mullen",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Alison",
      "family": "Phillips",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Arjang",
      "family": "Amini",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Joanne",
      "family": "Fabrycki",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Richard M.",
      "family": "Bartholomew",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Steven W.",
      "family": "Brostoff",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Dennis J.",
      "family": "Carlo",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB1",
      "first-page": "542",
      "article-title": "Direct gene transfer to mouse melanoma by intratumor injection of free DNA",
      "volume": "3",
      "author": "Yang",
      "year": "1996",
      "journal-title": "Gene Ther."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "807",
      "DOI": "10.1146/annurev.mi.49.100195.004111",
      "article-title": "Viral vectors in gene therapy",
      "volume": "49",
      "author": "Smith",
      "year": "1995",
      "journal-title": "Annu. Rev. Microbiol."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "217",
      "DOI": "10.1016/S0167-7799(97)01036-6",
      "article-title": "Biomedical applications of nanotechnology \u2013 implications for drug targeting and gene therapy",
      "volume": "15",
      "author": "Davis",
      "year": "1997",
      "journal-title": "Trends Biotechnol."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB4",
      "doi-asserted-by": "crossref",
      "first-page": "1465",
      "DOI": "10.1126/science.1690918",
      "article-title": "Direct gene transfer into mouse muscle in vivo",
      "volume": "247",
      "author": "Wolff",
      "year": "1990",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB5",
      "first-page": "239",
      "article-title": "Liposomes as carriers of DNA",
      "volume": "6",
      "author": "Nicolau",
      "year": "1989",
      "journal-title": "Crit. Rev. Ther. Drug Carrier Syst."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "102",
      "DOI": "10.1038/scientificamerican0697-102",
      "article-title": "Nonviral strategies for gene therapy",
      "volume": "276",
      "author": "Felgner",
      "year": "1997",
      "journal-title": "Sci. Am."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "511",
      "DOI": "10.1089/hum.1997.8.5-511",
      "article-title": "Nomenclature for synthetic gene delivery systems",
      "volume": "8",
      "author": "Felgner",
      "year": "1997",
      "journal-title": "Hum. Gene Ther."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB8",
      "doi-asserted-by": "crossref",
      "first-page": "3410",
      "DOI": "10.1073/pnas.87.9.3410",
      "article-title": "Transferrin\u2013polycation conjugates as carriers for DNA uptake into cells",
      "volume": "87",
      "author": "Wagner",
      "year": "1990",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "226",
      "DOI": "10.1021/bc00010a006",
      "article-title": "DNA-binding transferrin conjugates as functional gene-delivery agents: synthesis by linkage of polylysine or ethidium homodimer to the transferrin carbohydrate moiety",
      "volume": "2",
      "author": "Wagner",
      "year": "1991",
      "journal-title": "Bioconjug. Chem."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "372",
      "DOI": "10.1021/bc00023a012",
      "article-title": "Polyamidoamine cascade polymers mediate efficient transfection of cells in culture",
      "volume": "4",
      "author": "Haensler",
      "year": "1993",
      "journal-title": "Bioconjug. Chem."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB11",
      "doi-asserted-by": "crossref",
      "first-page": "10560",
      "DOI": "10.1074/jbc.271.18.10560",
      "article-title": "Target cell-specific DNA transfer mediated by a chimeric multidomain protein \u2013 novel non-viral gene delivery system",
      "volume": "271",
      "author": "Fominaya",
      "year": "1996",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "1395",
      "DOI": "10.1089/hum.1996.7.12-1395",
      "article-title": "Gene transfer into mammalian cells using histone-condensed plasmid DNA",
      "volume": "7",
      "author": "Fritz",
      "year": "1996",
      "journal-title": "Hum. Gene Ther."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB13",
      "first-page": "448",
      "article-title": "A novel DNA\u2013peptide complex for efficient gene transfer and expression in mammalian cells",
      "volume": "3",
      "author": "Gottschalk",
      "year": "1996",
      "journal-title": "Gene Ther."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "33647",
      "DOI": "10.1074/jbc.271.52.33647",
      "article-title": "Targeting DNA to cells with basic fibroblast growth factor (FGF2)",
      "volume": "271",
      "author": "Sosnowski",
      "year": "1996",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "8850",
      "DOI": "10.1073/pnas.88.19.8850",
      "article-title": "Adenovirus enhancement of transferrin-polylysine-mediated gene delivery",
      "volume": "88",
      "author": "Curiel",
      "year": "1991",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB16",
      "first-page": "S31",
      "article-title": "Nonviral gene delivery: vehicle and delivery characterization",
      "volume": "8",
      "author": "Lollo",
      "year": "1997",
      "journal-title": "Blood Coagul. Fibrinol."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "14621",
      "DOI": "10.1016/S0021-9258(18)68081-0",
      "article-title": "Receptor-mediated gene delivery and expression in vivo",
      "volume": "263",
      "author": "Wu",
      "year": "1988",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "533",
      "DOI": "10.1021/bc00018a012",
      "article-title": "Gene transfer into hepatocytes using asialoglycoprotein receptor mediated endocytosis of DNA complexed with an artificial tetra-antennary galactose ligand",
      "volume": "3",
      "author": "Plank",
      "year": "1992",
      "journal-title": "Bioconjug. Chem."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB19",
      "first-page": "47",
      "article-title": "Uptake of liposomes by rat and mouse heptocytes and Kupffer cells",
      "volume": "47",
      "author": "Scherphof",
      "year": "1983",
      "journal-title": "Biol. Cell"
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "683",
      "DOI": "10.1002/hep.1840050427",
      "article-title": "The liver sieve: considerations concerning the structure and function of endothelial fenestrae, the sinusoidal wall and the space of Disse",
      "volume": "5",
      "author": "Wisse",
      "year": "1985",
      "journal-title": "Hepatology"
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB21",
      "doi-asserted-by": "crossref",
      "first-page": "133",
      "DOI": "10.1615/CritRevTherDrugCarrierSyst.v14.i2.20",
      "article-title": "Nonviral vectors for in vivo gene delivery: physicochemical and pharmacokinetic considerations",
      "volume": "14",
      "author": "Mahato",
      "year": "1997",
      "journal-title": "Crit. Rev. Ther. Drug Carrier Syst."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "1129",
      "DOI": "10.1089/hum.1995.6.9-1129",
      "article-title": "Nonviral gene therapy: the promise of genes as pharmaceutical products",
      "volume": "6",
      "author": "Ledley",
      "year": "1995",
      "journal-title": "Hum. Gene Ther."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "1595",
      "DOI": "10.1023/A:1016420102549",
      "article-title": "Pharmaceutical approach to somatic gene therapy",
      "volume": "13",
      "author": "Ledley",
      "year": "1996",
      "journal-title": "Pharm. Res."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "135",
      "DOI": "10.1016/S0169-409X(97)00031-8",
      "article-title": "Toward development of a non-viral gene therapeutic",
      "volume": "26",
      "author": "Smith",
      "year": "1997",
      "journal-title": "Adv. Drug Deliv. Rev."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "1437",
      "DOI": "10.1089/hum.1996.7.12-1437",
      "article-title": "Activation of the complement system by synthetic DNA complexes: a potential barrier for intravenous gene delivery",
      "volume": "7",
      "author": "Plank",
      "year": "1996",
      "journal-title": "Hum. Gene Ther."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB26",
      "first-page": "269",
      "article-title": "Atomic force microscopic analysis of the influence of the molecular weight of poly(l)lysine on the size of polyelectrolyte complexes formed with DNA",
      "volume": "3",
      "author": "Wolfert",
      "year": "1996",
      "journal-title": "Gene Ther."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB27",
      "doi-asserted-by": "crossref",
      "first-page": "16985",
      "DOI": "10.1016/S0021-9258(18)71447-6",
      "article-title": "Targeting genes: delivery and persistent expression of a foreign gene driven by mammalian regulatory elements in vivo",
      "volume": "264",
      "author": "Wu",
      "year": "1989",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "255",
      "DOI": "10.1111/j.1432-1033.1994.tb20049.x",
      "article-title": "An evaluation of receptor-mediated gene transfer using synthetic DNA\u2013ligand complexes",
      "volume": "226",
      "author": "Perales",
      "year": "1994",
      "journal-title": "Eur. J. Biochem."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "1095",
      "DOI": "10.1089/hum.1994.5.9-1095",
      "article-title": "Overexpression of human methylmalonyl CoA mutase in mice after in vivo gene transfer with asialoglycoprotein/polylysine/DNA complexes",
      "volume": "5",
      "author": "Stankovics",
      "year": "1994",
      "journal-title": "Hum. Gene Ther."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB30",
      "unstructured": "K.V. Shah, Polyomaviruses, in: B.N. Fields (Ed.), Virology, Raven Press, New York, 1990, pp. 1609\u20131623."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "619",
      "DOI": "10.1002/bip.360300514",
      "article-title": "Condensation of DNA by trivalent cations. 1. Effects of DNA length and topology on the size and shape of condensed particles",
      "volume": "30",
      "author": "Arscott",
      "year": "1990",
      "journal-title": "Biopolymers"
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "2221",
      "DOI": "10.1093/nar/25.11.2221",
      "article-title": "AFM analysis of DNA\u2013protamine complexes bound to mica",
      "volume": "25",
      "author": "Allen",
      "year": "1997",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "1471",
      "DOI": "10.1002/bip.360311305",
      "article-title": "Condensation of DNA by multivalent cations: considerations on mechanism",
      "volume": "31",
      "author": "Bloomfield",
      "year": "1991",
      "journal-title": "Biopolymers"
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "334",
      "DOI": "10.1016/S0959-440X(96)80052-2",
      "article-title": "DNA condensation",
      "volume": "6",
      "author": "Bloomfield",
      "year": "1996",
      "journal-title": "Curr. Opin. Struct. Biol."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "496",
      "DOI": "10.1042/bst0190496",
      "article-title": "Light scattering studies on DNA condensation",
      "volume": "19",
      "author": "Bloomfield",
      "year": "1990",
      "journal-title": "Biochem. Soc. Trans."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB36",
      "doi-asserted-by": "crossref",
      "first-page": "7398",
      "DOI": "10.1074/jbc.272.11.7398",
      "article-title": "Biochemical and functional characterization of DNA complexes capable of targeting genes to hepatocytes via the asialoglycoprotein receptor",
      "volume": "272",
      "author": "Perales",
      "year": "1997",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB37",
      "doi-asserted-by": "crossref",
      "first-page": "4255",
      "DOI": "10.1073/pnas.88.10.4255",
      "article-title": "Transferrin\u2013polycation\u2013DNA complexes: the effect of polycations on the structure of the complex and DNA delivery to cells",
      "volume": "88",
      "author": "Wagner",
      "year": "1991",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB38",
      "doi-asserted-by": "crossref",
      "first-page": "1971",
      "DOI": "10.1016/S0021-9258(18)69851-5",
      "article-title": "The thiobarbituric acid assay of sialic acids",
      "volume": "234",
      "author": "Warren",
      "year": "1959",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB39",
      "doi-asserted-by": "crossref",
      "first-page": "1425",
      "DOI": "10.1093/oxfordjournals.jbchem.a131830",
      "article-title": "Distribution of neuraminidase in Arthobacter and its purification by affinity chromatography",
      "volume": "82",
      "author": "Uchida",
      "year": "1977",
      "journal-title": "J. Biochem."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "306",
      "DOI": "10.1021/bc00028a004",
      "article-title": "Preparation of asialoorosomucoid-polylysine conjugates",
      "volume": "5",
      "author": "McKee",
      "year": "1994",
      "journal-title": "Bioconjug. Chem."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB41",
      "doi-asserted-by": "crossref",
      "first-page": "612",
      "DOI": "10.1021/bc00030a017",
      "article-title": "Targeted delivery of DNA using YEE(GalNAcAH)3, a synthetic glycopeptide ligand for the asialoglycoprotein receptor",
      "volume": "5",
      "author": "Merwin",
      "year": "1994",
      "journal-title": "Bioconjug. Chem."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB42",
      "doi-asserted-by": "crossref",
      "first-page": "3742",
      "DOI": "10.1021/ma00218a005",
      "article-title": "Proton NMR characterization of poly(ethylene glycols) and derivatives",
      "volume": "23",
      "author": "Dust",
      "year": "1990",
      "journal-title": "Macromolecules"
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB43",
      "unstructured": "J. Sambrook, E.F. Fritsch, T. Maniatis, Molecular Cloning: A Laboratory Manual, 2nd edn., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB44",
      "doi-asserted-by": "crossref",
      "first-page": "8481",
      "DOI": "10.1074/jbc.271.14.8481",
      "article-title": "Folate-targeted, anionic liposome-entrapped polylysine-condensed DNA for tumor cell-specific gene transfer",
      "volume": "271",
      "author": "Lee",
      "year": "1996",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB45",
      "doi-asserted-by": "crossref",
      "first-page": "823",
      "DOI": "10.1038/sj.gt.3300454",
      "article-title": "The influence of polymer structure on the interactions of cationic polymers with DNA and morphology of the resulting complexes",
      "volume": "4",
      "author": "Tang",
      "year": "1997",
      "journal-title": "Gene Ther."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB46",
      "doi-asserted-by": "crossref",
      "first-page": "29",
      "DOI": "10.1016/S0005-2736(96)00171-X",
      "article-title": "Interaction of surfactants with DNA. Role of hydrophobicity and surface charge on intercalation and DNA melting",
      "volume": "1323",
      "author": "Bhattacharya",
      "year": "1997",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB47",
      "unstructured": "M.A. Hayat and S.E. MIller, Negative Staining, McGraw-Hill, New York, 1990."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB48",
      "doi-asserted-by": "crossref",
      "first-page": "165",
      "DOI": "10.1016/S0169-409X(96)00456-5",
      "article-title": "Stealth\u00ae liposomes: from theory to product",
      "volume": "24",
      "author": "Ceh",
      "year": "1997",
      "journal-title": "Adv. Drug Deliv. Rev."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB49",
      "doi-asserted-by": "crossref",
      "first-page": "553",
      "DOI": "10.1089/hum.1995.6.5-553",
      "article-title": "Cancer gene therapy using plasmid DNA: pharmacokinetic study of DNA following injection in mice",
      "volume": "6",
      "author": "Lew",
      "year": "1995",
      "journal-title": "Hum. Gene Ther."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB50",
      "doi-asserted-by": "crossref",
      "first-page": "1437",
      "DOI": "10.1002/bip.360311210",
      "article-title": "DNA interpolyelectrolyte complexes as a tool for efficient cell transformation",
      "volume": "31",
      "author": "Kabanov",
      "year": "1991",
      "journal-title": "Biopolymers"
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB51",
      "doi-asserted-by": "crossref",
      "first-page": "1701",
      "DOI": "10.1089/hum.1996.7.14-1701",
      "article-title": "Detailed analysis of structures and formulations of cationic lipids for efficient gene transfer to the lung",
      "volume": "7",
      "author": "Lee",
      "year": "1996",
      "journal-title": "Hum. Gene Ther."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB52",
      "doi-asserted-by": "crossref",
      "first-page": "7934",
      "DOI": "10.1073/pnas.89.17.7934",
      "article-title": "Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin\u2013polylysine\u2013DNA complexes: toward a synthetic virus-like gene-transfer vehicle",
      "volume": "89",
      "author": "Wagner",
      "year": "1992",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB53",
      "doi-asserted-by": "crossref",
      "first-page": "6099",
      "DOI": "10.1073/pnas.89.13.6099",
      "article-title": "Coupling of adenovirus to transferrin\u2013polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes",
      "volume": "89",
      "author": "Wagner",
      "year": "1992",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB54",
      "doi-asserted-by": "crossref",
      "first-page": "12918",
      "DOI": "10.1016/S0021-9258(18)99963-1",
      "article-title": "The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems",
      "volume": "269",
      "author": "Plank",
      "year": "1994",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB55",
      "doi-asserted-by": "crossref",
      "first-page": "11265",
      "DOI": "10.1016/S0021-9258(18)82119-6",
      "article-title": "Fate of DNA targeted to the liver by asialoglycoprotein receptor-mediated endocytosis in vivo. Prolonged persistence in cytoplasmic vesicles after partial hepatectomy",
      "volume": "268",
      "author": "Chowdhury",
      "year": "1993",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB56",
      "doi-asserted-by": "crossref",
      "first-page": "14338",
      "DOI": "10.1016/S0021-9258(18)98689-8",
      "article-title": "Receptor-mediated gene delivery in vivo. Partial correction of genetic analbuminemia in Nagase rats",
      "volume": "266",
      "author": "Wu",
      "year": "1991",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB57",
      "first-page": "847",
      "article-title": "In vivo transfection of hepatitis C virus complementary DNA into rodent liver by asialoglycoprotein receptor mediated gene delivery",
      "volume": "22",
      "author": "Yamamoto",
      "year": "1995",
      "journal-title": "Hepatology"
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB58",
      "doi-asserted-by": "crossref",
      "first-page": "2123",
      "DOI": "10.1089/hum.1996.7.17-2123",
      "article-title": "Characterization of vectors for gene therapy formed by self-assembly of DNA with synthetic block co-polymers",
      "volume": "7",
      "author": "Wolfert",
      "year": "1996",
      "journal-title": "Hum. Gene Ther."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB59",
      "doi-asserted-by": "crossref",
      "first-page": "99",
      "DOI": "10.1016/0005-2736(94)90038-8",
      "article-title": "Effect of liposome size on the circulation time and intraorgan distribution of amphipathic poly(ethylene glycol)-containing liposomes",
      "volume": "1190",
      "author": "Litzinger",
      "year": "1994",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB60",
      "doi-asserted-by": "crossref",
      "first-page": "43",
      "DOI": "10.1016/S0005-2760(96)00157-9",
      "article-title": "Serum\u2013liposome interaction is an oxygen-dependent process",
      "volume": "1345",
      "author": "Foradada",
      "year": "1997",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB61",
      "unstructured": "P.C. Hiemenz, Principles of Colloid and Surface Chemistry, 2nd edn., Marcel Dekker, New York, NY, 1986."
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB62",
      "doi-asserted-by": "crossref",
      "first-page": "354",
      "DOI": "10.1016/S0304-4165(98)00004-X",
      "article-title": "Novel vectors for gene delivery formed by self-assembly of DNA with poly(l-lysine) grafted with hydrophilic polymers",
      "volume": "1380",
      "author": "Toncheva",
      "year": "1998",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "10.1016/S0167-4781(98)00274-7_BIB63",
      "doi-asserted-by": "crossref",
      "first-page": "133",
      "DOI": "10.1016/0005-2736(91)90201-I",
      "article-title": "Pharmacokinetics of stealth versus conventional liposomes: effect of dose",
      "volume": "1068",
      "author": "Allen",
      "year": "1991",
      "journal-title": "Biochim. Biophys. Acta"
    }
  ],
  "container-title": "Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0167478198002747?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0167478198002747?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        5,
        5
      ]
    ],
    "date-time": "2021-05-05T01:45:18Z",
    "timestamp": 1620179118000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0167478198002747"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1999,
        2
      ]
    ]
  },
  "references-count": 63,
  "journal-issue": {
    "issue": "2",
    "published-print": {
      "date-parts": [
        [
          1999,
          2
        ]
      ]
    }
  },
  "alternative-id": [
    "S0167478198002747"
  ],
  "URL": "http://dx.doi.org/10.1016/S0167-4781(98)00274-7",
  "relation": {},
  "ISSN": [
    "0167-4781"
  ],
  "subject": [],
  "container-title-short": "Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression",
  "published": {
    "date-parts": [
      [
        1999,
        2
      ]
    ]
  }
}