DOI: 10.1016/s0166-4328(05)80134-2. Hippocampal nerve growth factor levels are related to spatial learning ability in aged rats

Hippocampal nerve growth factor levels are related to spatial learning ability in aged rats

10.1016/s0166-4328(05)80134-2

Crossref journal-article

Elsevier BV

Behavioural Brain Research (78)

Bibliography

Henriksson, B. G., SÃ¶derstrÃ¶m, S., Gower, A. J., Ebendal, T., Winblad, B., & Mohammed, A. H. (1992). Hippocampal nerve growth factor levels are related to spatial learning ability in aged rats. Behavioural Brain Research, 48(1), 15â20.

Authors 6

B.G. Henriksson (first)
S. Söderström (additional)
A.J. Gower (additional)
T. Ebendal (additional)
B. Winblad (additional)
A.H. Mohammed (additional)

References 64 Referenced 77

10.1126/science.2897715 / Science / Expression of the β-nerve growth factor gene in hippocampal neurons by Ayer-LeLievre (1988)
10.1016/0896-6273(89)90040-8 / Neuron / Trophic factors and neuronal survival by Barde (1989)
10.1037/0735-7044.99.6.1040 / Behav. Neurosci. / An age comparison of the rates of acquisition and forgetting of spatial information in relation to long term enhancement of hippocampal synapses by Barnes (1985)
10.1126/science.7046051 / Science / The cholinergic hypothesis of geriatric memory dysfunction by Bartus (1982)
{'key': '10.1016/S0166-4328(05)80134-2_bib5', 'series-title': 'Ergot Compounds and Brain function: Neuroendocrine and Neuropsychiatric Aspects', 'first-page': '295', 'article-title': 'Biogenic amines in human brain in normal aging, senile dementia and chronic alcoholism', 'author': 'Carlsson', 'year': '1980'} / Ergot Compounds and Brain function: Neuroendocrine and Neuropsychiatric Aspects / Biogenic amines in human brain in normal aging, senile dementia and chronic alcoholism by Carlsson (1980)
10.1016/S0197-4580(88)80117-9 / Neurobiol. Aging. / Review: age-dependent alterations in hippocampal synaptic plasticity: relation to memory disorders by de Toledo-Morrell (1988)
10.1016/0955-2235(89)90008-2 / Prog. Growth Factor Res. / NGF in CNS: experimental data and clinical implications by Ebendal (1989)
10.1016/0896-6273(90)90090-3 / Neuron / Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor family by Ernfors (1990)
10.1016/0304-3940(92)90494-R / Neurosci. Lett. / Increased expression of brain derived neurotrophic factor is associated with improved spatial learning and enriched environment by Falkenberg (1992)
{'key': '10.1016/S0166-4328(05)80134-2_bib10', 'article-title': 'Nerve growth factor: amelioration of degenerative changes in cholinergic neurons of the brain', 'author': 'Fischer', 'year': '1991'} / Nerve growth factor: amelioration of degenerative changes in cholinergic neurons of the brain by Fischer (1991)
10.1111/j.1460-9568.1989.tb00772.x / Eur. J. Neurosci. / Degenerative changes in forebrain cholinergic nuclei correlate with cognitive impairments in aged rats by Fischer (1989)
10.1038/329065a0 / Nature / Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor by Fischer (1987)
10.1523/JNEUROSCI.06-10-02837.1986 / J. Neurosci. / Cholinergic septal grafts into the hippocampal formation improve spatial learning and memory in aged rats by an atropine sensitive mechanism by Gage (1986)
10.1016/0197-4580(89)90047-X / Neurobiol. Aging. / Age-related impairments in spatial memory are independent of those of sensorimotor skills by Gage (1989)
10.1523/JNEUROSCI.04-11-02856.1984 / J. Neurosci. / Regional changes in brain glucose metabolism reflect cognitive impairments in aged rats by Gage (1984)
10.1016/0197-4580(90)90111-C / Neurobiol. Aging / Markers for biogenic amines in the aged rat brain: relationship to decline in spatial learning ability by Gallagher (1990)
10.1016/S0197-4580(88)80112-X / Neurobiol. Aging. / Spatial learning deficits in old rats: a model for memory decline in the aged by Gallagher (1988)
10.1016/0006-8993(86)91486-1 / Brain Res. / Aged rats need a preserved complement of perforated axospinous synapses per hippocampal neuron to maintain good spatial memory by Geinisman (1986)
10.1073/pnas.83.9.3027 / Proc. Natl. Acad. Sci. U.S.A. / Loss of perforated synapses in the dentate gyrus: morphological substrate of memory deficit in aged rats by Geinisman (1986)
10.1016/0197-4580(89)90029-8 / Neurobiol. Aging. / Age-related changes in dopaminergic and serotonergic indices in the rats forebrain by Godefroy (1989)
10.1016/0006-8993(89)91626-0 / Brain Res. / NGF receptor immunoreactivity in aged rat brain by Gomez-Pinilla (1989)
10.1016/0024-3205(90)90036-Q / Life Sci. / Regional brain monoamine levels and utilization in middle-aged rats by Hadfield (1989)
{'key': '10.1016/S0166-4328(05)80134-2_bib23', 'series-title': "Growth Factors in Alzheimer's Disease", 'year': '1991'} / Growth Factors in Alzheimer's Disease (1991)
10.1016/0006-8993(90)90348-F / Brain Res. / Nerve growth factor and choline acetyl-transferase activity in the brain of cognitively impaired aged rats by Hellweg (1990)
10.1038/350678a0 / Nature / High affinity NGF binding requires coexpression of the Trk proto-oncogene and the low-affinity NGF receptor by Hempstead (1991)
10.1016/0014-4886(89)90155-6 / Exp. Neurol. / NGF receptor gene expression is decreased in the nucleus basalis in Alzheimer's disease by Higgins (1989)
10.1016/0006-8993(90)91178-J / Brain Res. / Age-related structural changes in the rat hippocampus: correlation with working memory deficiency by Kadar (1990)
10.1016/0006-8993(89)91125-6 / Brain Res. / Loss of NGF receptor immunoreactivity in basal forebrain neurons of aged rats: correlation with spatial memory impairment by Koh (1989)
10.1016/0006-8993(88)91015-3 / Brain Res. / Age-related loss of nerve growth factor sensitivity in rat basal forebrain neurons by Koh (1988)
10.1016/0014-4886(89)90154-4 / Exp. Neurol. / Localization of nerve growth factor receptor messenger RNA and protein in the adult rat brain by Koh (1989)
10.1002/j.1460-2075.1985.tb03791.x / EMBO J. / Levels of nerve growth factor and its mRNA in the central nervous system of the rat correlate with cholinergic innervation by Korsching (1985)
10.1016/0076-6879(87)47108-5 / Meth. Enzymol. / Two-site enzyme immunoassay for nerve growth factor by Korsching (1985)
10.1016/0031-9384(90)90364-A / Physiol. Behav. / Age-related changes in spontaneous behavior and learning in NMRI mice from maturity to middle age by Lamberty (1990)
10.1016/0031-9384(92)90206-H / Physiol. Behav. / Age-related changes in spontaneous behavior and learning in NMRI mice from middle to old age by Lamberty (1992)
10.1016/S0197-4580(88)80116-7 / Neurobiol. Aging. / Review: hippocampal neurobiological mechanisms of age-related memory dysfunction by Landfield (1988)
10.1016/0006-8993(78)90655-8 / Brain Res. / Impaired synaptic potentiation processes in the hippocampus of aged, memory-deficient rats by Landfield (1978)
10.1016/0022-1759(87)90103-7 / J. Immunol. Meth. / Highly sensitive enzyme immunoassay for β-nerve growth factor by Lärkfors (1987)
10.1016/0169-328X(87)90044-1 / Mol. Brain Res. / Decreased levels of nerve growth factor (NGF) and its messenger RNA in the aged rat brain by Lärkfors (1987)
10.1126/science.3306916 / Science / The nerve growth factor 35 years later by Levi-Montalcini (1987)
10.1016/0896-6273(90)90089-X / Neuron / NT-3, BDNF, and NGF in the developing rat nervous system: parallel as well as reciprocal patterns of expression by Maisonpierre (1990)
10.1016/0197-4580(91)90036-J / Neurobiol. Aging. / Postnatal handling attenuates certain neuroendocrine, anatomical, and cognitive dysfunctions associated with aging in female rats by Meaney (1991)
10.1126/science.3340858 / Science / Effect of neonatal handling on age-related impairments associated with the hippocampus by Meany (1988)
10.1093/geronj/32.2.129 / J. Gerontol. / Aging-induced changes in acetylcholine and serotonin content of discrete brain nuclei by Meek (1977)
10.1016/0197-4580(89)90023-7 / Neurobiol. Aging. / Age-related differences in brain choline acetyltransferase, cholinesterase and muscarinic receptor sites in two strains of rats by Michalek (1989)
10.1016/0197-4580(92)90013-N / Neurobiol. Aging / Persistent changes in behaviour and brain serotonin during aging in rats subjected to infant nasal viral infection by Mohammed (1991)
{'key': '10.1016/S0166-4328(05)80134-2_bib46', 'first-page': '285', 'article-title': 'Learning deficits in aged rats pretreated chronically with barbital and tested late in abstinence: alleviation by tetrahydroaminoacridine', 'volume': '2', 'author': 'Mohammed', 'year': '1990', 'journal-title': 'J. Neurotransm.'} / J. Neurotransm. / Learning deficits in aged rats pretreated chronically with barbital and tested late in abstinence: alleviation by tetrahydroaminoacridine by Mohammed (1990)
10.1016/0006-8993(90)90195-H / Brain Res. / Environmental influence on behaviour and nerve growth factor in the brain by Mohammed (1990)
10.1038/297681a0 / Nature / Place navigation impaired in rats with hippocampal lesions by Morris (1978)
{'key': '10.1016/S0166-4328(05)80134-2_bib49', 'series-title': 'The hippocampus as a cognitive map', 'author': "O'Keefe", 'year': '1978'} / The hippocampus as a cognitive map by O'Keefe (1978)
10.1017/S0140525X00062713 / Behav. Brain Sci. / Hippocampus, Space and Memory by Olton (1979)
10.1016/0306-4522(90)90304-M / Neuroscience / Distribution of nerve growth factor receptor-like immunoreactivity in the adult rat central nervous system. Effect of colchicine and correlation with the cholinergic system by Pioro (1990)
10.1038/325593a0 / Nature / Gene transfer and molecular cloning of the rat nerve growth factor receptor by Radeke (1987)
10.1016/0024-3205(88)90349-9 / Life Sci. / Changes in biogenic amines in rat hippocampus during development and aging by Santiago (1988)
10.1016/0006-8993(79)90303-2 / Brain Res. / Nerve growth factor (NGF) in the rat CNS: absence for specific retrograde axonal transport and tyrosine hydroxylase induction in locus coeruleus and substantia nigra by Schwab (1979)
10.1016/0006-8993(84)91338-6 / Brain Res. / Specific retrograde transport of nerve growth factor (NGF) from neocortex to nucleus basalis in the rat by Seiler (1983)
10.1002/jnr.490270427 / J. Neurosci. Res. / Recombinant human β-nerve growth factor (NGF): biological activity and properties in an enzyme immunoassay by Söderström (1990)
10.1126/science.1688664 / Science / Survival of adult basal forebrain cholinergic neurons after loss of target neurons by Sofroniew (1990)
{'key': '10.1016/S0166-4328(05)80134-2_bib58', 'series-title': 'Neurobiology of the Hippocampus', 'first-page': '491', 'article-title': 'The hippocampus and neuropsychology of memory', 'author': 'Squire', 'year': '1985'} / Neurobiology of the Hippocampus / The hippocampus and neuropsychology of memory by Squire (1985)
{'key': '10.1016/S0166-4328(05)80134-2_bib59', 'first-page': '165', 'article-title': 'The changing face of neurotrophic factors', 'volume': '14', 'author': 'Thoenen', 'year': '1991', 'journal-title': 'Trends Pharmacol. Sci.'} / Trends Pharmacol. Sci. / The changing face of neurotrophic factors by Thoenen (1991)
10.1152/physrev.1980.60.4.1284 / Physiol. Rev. / Physiology of nerve growth factor by Thoenen (1980)
{'key': '10.1016/S0166-4328(05)80134-2_bib61', 'first-page': '593', 'article-title': 'Messenger RNAs for trk and the low-affinity NGF receptor in rat basal forebrain', 'volume': '2', 'author': 'Vasquez', 'year': '1991', 'journal-title': 'Neuro-Report'} / Neuro-Report / Messenger RNAs for trk and the low-affinity NGF receptor in rat basal forebrain by Vasquez (1991)
10.1073/pnas.83.3.817 / Proc. Natl. Acad. Sci. U.S.A. / Developmental and regional expression of β-nerve growth factor messenger RNA and protein in the rat central nervous system by Whittemore (1986)
10.1016/0165-0173(87)90008-7 / Brain Res. Rev. / The expression, localization and functional significance of β-nerve growth factor in the central nervous system by Whittemore (1987)
10.1007/BF00266747 / Histochemistry / Local cerebral glucose utilization in the brain of old learning impaired rats by Wree (1991)

Dates

Type	When
Created	18 years, 9 months ago (Nov. 21, 2006, 12:33 p.m.)
Deposited	6 years, 4 months ago (April 22, 2019, 8:18 a.m.)
Indexed	2 months ago (June 25, 2025, 1:25 a.m.)
Issued	33 years, 3 months ago (May 1, 1992)
Published	33 years, 3 months ago (May 1, 1992)
Published Print	33 years, 3 months ago (May 1, 1992)

Funders 0

None

BibTeX

@article{Henriksson_1992, title={Hippocampal nerve growth factor levels are related to spatial learning ability in aged rats}, volume={48}, ISSN={0166-4328}, url={http://dx.doi.org/10.1016/s0166-4328(05)80134-2}, DOI={10.1016/s0166-4328(05)80134-2}, number={1}, journal={Behavioural Brain Research}, publisher={Elsevier BV}, author={Henriksson, B.G. and Söderström, S. and Gower, A.J. and Ebendal, T. and Winblad, B. and Mohammed, A.H.}, year={1992}, month=may, pages={15–20} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        6,
        25
      ]
    ],
    "date-time": "2025-06-25T05:25:07Z",
    "timestamp": 1750829107979
  },
  "reference-count": 64,
  "publisher": "Elsevier BV",
  "issue": "1",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1992,
            5,
            1
          ]
        ],
        "date-time": "1992-05-01T00:00:00Z",
        "timestamp": 704678400000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1992,
        5
      ]
    ]
  },
  "DOI": "10.1016/s0166-4328(05)80134-2",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2006,
        11,
        21
      ]
    ],
    "date-time": "2006-11-21T17:33:35Z",
    "timestamp": 1164130415000
  },
  "page": "15-20",
  "source": "Crossref",
  "is-referenced-by-count": 77,
  "title": "Hippocampal nerve growth factor levels are related to spatial learning ability in aged rats",
  "prefix": "10.1016",
  "volume": "48",
  "author": [
    {
      "given": "B.G.",
      "family": "Henriksson",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "S.",
      "family": "S\u00f6derstr\u00f6m",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "A.J.",
      "family": "Gower",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "T.",
      "family": "Ebendal",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "B.",
      "family": "Winblad",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "A.H.",
      "family": "Mohammed",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib1",
      "doi-asserted-by": "crossref",
      "first-page": "1339",
      "DOI": "10.1126/science.2897715",
      "article-title": "Expression of the \u03b2-nerve growth factor gene in hippocampal neurons",
      "volume": "240",
      "author": "Ayer-LeLievre",
      "year": "1988",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib2",
      "doi-asserted-by": "crossref",
      "first-page": "1525",
      "DOI": "10.1016/0896-6273(89)90040-8",
      "article-title": "Trophic factors and neuronal survival",
      "volume": "2",
      "author": "Barde",
      "year": "1989",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib3",
      "doi-asserted-by": "crossref",
      "first-page": "1040",
      "DOI": "10.1037/0735-7044.99.6.1040",
      "article-title": "An age comparison of the rates of acquisition and forgetting of spatial information in relation to long term enhancement of hippocampal synapses",
      "volume": "99",
      "author": "Barnes",
      "year": "1985",
      "journal-title": "Behav. Neurosci."
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib4",
      "doi-asserted-by": "crossref",
      "first-page": "408",
      "DOI": "10.1126/science.7046051",
      "article-title": "The cholinergic hypothesis of geriatric memory dysfunction",
      "volume": "217",
      "author": "Bartus",
      "year": "1982",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib5",
      "series-title": "Ergot Compounds and Brain function: Neuroendocrine and Neuropsychiatric Aspects",
      "first-page": "295",
      "article-title": "Biogenic amines in human brain in normal aging, senile dementia and chronic alcoholism",
      "author": "Carlsson",
      "year": "1980"
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib6",
      "doi-asserted-by": "crossref",
      "first-page": "581",
      "DOI": "10.1016/S0197-4580(88)80117-9",
      "article-title": "Review: age-dependent alterations in hippocampal synaptic plasticity: relation to memory disorders",
      "volume": "9",
      "author": "de Toledo-Morrell",
      "year": "1988",
      "journal-title": "Neurobiol. Aging."
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib7",
      "doi-asserted-by": "crossref",
      "first-page": "143",
      "DOI": "10.1016/0955-2235(89)90008-2",
      "article-title": "NGF in CNS: experimental data and clinical implications",
      "volume": "1",
      "author": "Ebendal",
      "year": "1989",
      "journal-title": "Prog. Growth Factor Res."
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib8",
      "doi-asserted-by": "crossref",
      "first-page": "511",
      "DOI": "10.1016/0896-6273(90)90090-3",
      "article-title": "Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor family",
      "volume": "5",
      "author": "Ernfors",
      "year": "1990",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib9",
      "doi-asserted-by": "crossref",
      "first-page": "153",
      "DOI": "10.1016/0304-3940(92)90494-R",
      "article-title": "Increased expression of brain derived neurotrophic factor is associated with improved spatial learning and enriched environment",
      "volume": "138",
      "author": "Falkenberg",
      "year": "1992",
      "journal-title": "Neurosci. Lett."
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib10",
      "article-title": "Nerve growth factor: amelioration of degenerative changes in cholinergic neurons of the brain",
      "author": "Fischer",
      "year": "1991"
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib11",
      "doi-asserted-by": "crossref",
      "first-page": "34",
      "DOI": "10.1111/j.1460-9568.1989.tb00772.x",
      "article-title": "Degenerative changes in forebrain cholinergic nuclei correlate with cognitive impairments in aged rats",
      "volume": "1",
      "author": "Fischer",
      "year": "1989",
      "journal-title": "Eur. J. Neurosci."
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib12",
      "doi-asserted-by": "crossref",
      "first-page": "65",
      "DOI": "10.1038/329065a0",
      "article-title": "Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor",
      "volume": "329",
      "author": "Fischer",
      "year": "1987",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib13",
      "doi-asserted-by": "crossref",
      "first-page": "2837",
      "DOI": "10.1523/JNEUROSCI.06-10-02837.1986",
      "article-title": "Cholinergic septal grafts into the hippocampal formation improve spatial learning and memory in aged rats by an atropine sensitive mechanism",
      "volume": "6",
      "author": "Gage",
      "year": "1986",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib14",
      "doi-asserted-by": "crossref",
      "first-page": "347",
      "DOI": "10.1016/0197-4580(89)90047-X",
      "article-title": "Age-related impairments in spatial memory are independent of those of sensorimotor skills",
      "volume": "10",
      "author": "Gage",
      "year": "1989",
      "journal-title": "Neurobiol. Aging."
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib15",
      "doi-asserted-by": "crossref",
      "first-page": "2856",
      "DOI": "10.1523/JNEUROSCI.04-11-02856.1984",
      "article-title": "Regional changes in brain glucose metabolism reflect cognitive impairments in aged rats",
      "volume": "4",
      "author": "Gage",
      "year": "1984",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib16",
      "doi-asserted-by": "crossref",
      "first-page": "507",
      "DOI": "10.1016/0197-4580(90)90111-C",
      "article-title": "Markers for biogenic amines in the aged rat brain: relationship to decline in spatial learning ability",
      "volume": "11",
      "author": "Gallagher",
      "year": "1990",
      "journal-title": "Neurobiol. Aging"
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib17",
      "doi-asserted-by": "crossref",
      "first-page": "549",
      "DOI": "10.1016/S0197-4580(88)80112-X",
      "article-title": "Spatial learning deficits in old rats: a model for memory decline in the aged",
      "volume": "9",
      "author": "Gallagher",
      "year": "1988",
      "journal-title": "Neurobiol. Aging."
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib18",
      "doi-asserted-by": "crossref",
      "first-page": "266",
      "DOI": "10.1016/0006-8993(86)91486-1",
      "article-title": "Aged rats need a preserved complement of perforated axospinous synapses per hippocampal neuron to maintain good spatial memory",
      "volume": "398",
      "author": "Geinisman",
      "year": "1986",
      "journal-title": "Brain Res."
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib19",
      "doi-asserted-by": "crossref",
      "first-page": "3027",
      "DOI": "10.1073/pnas.83.9.3027",
      "article-title": "Loss of perforated synapses in the dentate gyrus: morphological substrate of memory deficit in aged rats",
      "volume": "83",
      "author": "Geinisman",
      "year": "1986",
      "journal-title": "Proc. Natl. Acad. Sci. U.S.A."
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib20",
      "doi-asserted-by": "crossref",
      "first-page": "187",
      "DOI": "10.1016/0197-4580(89)90029-8",
      "article-title": "Age-related changes in dopaminergic and serotonergic indices in the rats forebrain",
      "volume": "10",
      "author": "Godefroy",
      "year": "1989",
      "journal-title": "Neurobiol. Aging."
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "255",
      "DOI": "10.1016/0006-8993(89)91626-0",
      "article-title": "NGF receptor immunoreactivity in aged rat brain",
      "volume": "479",
      "author": "Gomez-Pinilla",
      "year": "1989",
      "journal-title": "Brain Res."
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "295",
      "DOI": "10.1016/0024-3205(90)90036-Q",
      "article-title": "Regional brain monoamine levels and utilization in middle-aged rats",
      "volume": "46",
      "author": "Hadfield",
      "year": "1989",
      "journal-title": "Life Sci."
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib23",
      "series-title": "Growth Factors in Alzheimer's Disease",
      "year": "1991"
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "123",
      "DOI": "10.1016/0006-8993(90)90348-F",
      "article-title": "Nerve growth factor and choline acetyl-transferase activity in the brain of cognitively impaired aged rats",
      "volume": "537",
      "author": "Hellweg",
      "year": "1990",
      "journal-title": "Brain Res."
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "678",
      "DOI": "10.1038/350678a0",
      "article-title": "High affinity NGF binding requires coexpression of the Trk proto-oncogene and the low-affinity NGF receptor",
      "volume": "350",
      "author": "Hempstead",
      "year": "1991",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "222",
      "DOI": "10.1016/0014-4886(89)90155-6",
      "article-title": "NGF receptor gene expression is decreased in the nucleus basalis in Alzheimer's disease",
      "volume": "106",
      "author": "Higgins",
      "year": "1989",
      "journal-title": "Exp. Neurol."
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "113",
      "DOI": "10.1016/0006-8993(90)91178-J",
      "article-title": "Age-related structural changes in the rat hippocampus: correlation with working memory deficiency",
      "volume": "512",
      "author": "Kadar",
      "year": "1990",
      "journal-title": "Brain Res."
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "397",
      "DOI": "10.1016/0006-8993(89)91125-6",
      "article-title": "Loss of NGF receptor immunoreactivity in basal forebrain neurons of aged rats: correlation with spatial memory impairment",
      "volume": "498",
      "author": "Koh",
      "year": "1989",
      "journal-title": "Brain Res."
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "396",
      "DOI": "10.1016/0006-8993(88)91015-3",
      "article-title": "Age-related loss of nerve growth factor sensitivity in rat basal forebrain neurons",
      "volume": "440",
      "author": "Koh",
      "year": "1988",
      "journal-title": "Brain Res."
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "209",
      "DOI": "10.1016/0014-4886(89)90154-4",
      "article-title": "Localization of nerve growth factor receptor messenger RNA and protein in the adult rat brain",
      "volume": "106",
      "author": "Koh",
      "year": "1989",
      "journal-title": "Exp. Neurol."
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "1389",
      "DOI": "10.1002/j.1460-2075.1985.tb03791.x",
      "article-title": "Levels of nerve growth factor and its mRNA in the central nervous system of the rat correlate with cholinergic innervation",
      "volume": "4",
      "author": "Korsching",
      "year": "1985",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib32",
      "doi-asserted-by": "crossref",
      "first-page": "167",
      "DOI": "10.1016/0076-6879(87)47108-5",
      "article-title": "Two-site enzyme immunoassay for nerve growth factor",
      "volume": "147",
      "author": "Korsching",
      "year": "1985",
      "journal-title": "Meth. Enzymol."
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "1137",
      "DOI": "10.1016/0031-9384(90)90364-A",
      "article-title": "Age-related changes in spontaneous behavior and learning in NMRI mice from maturity to middle age",
      "volume": "47",
      "author": "Lamberty",
      "year": "1990",
      "journal-title": "Physiol. Behav."
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "81",
      "DOI": "10.1016/0031-9384(92)90206-H",
      "article-title": "Age-related changes in spontaneous behavior and learning in NMRI mice from middle to old age",
      "volume": "51",
      "author": "Lamberty",
      "year": "1992",
      "journal-title": "Physiol. Behav."
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib35",
      "doi-asserted-by": "crossref",
      "first-page": "571",
      "DOI": "10.1016/S0197-4580(88)80116-7",
      "article-title": "Review: hippocampal neurobiological mechanisms of age-related memory dysfunction",
      "volume": "9",
      "author": "Landfield",
      "year": "1988",
      "journal-title": "Neurobiol. Aging."
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib36",
      "doi-asserted-by": "crossref",
      "first-page": "85",
      "DOI": "10.1016/0006-8993(78)90655-8",
      "article-title": "Impaired synaptic potentiation processes in the hippocampus of aged, memory-deficient rats",
      "volume": "150",
      "author": "Landfield",
      "year": "1978",
      "journal-title": "Brain Res."
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib37",
      "doi-asserted-by": "crossref",
      "first-page": "41",
      "DOI": "10.1016/0022-1759(87)90103-7",
      "article-title": "Highly sensitive enzyme immunoassay for \u03b2-nerve growth factor",
      "volume": "97",
      "author": "L\u00e4rkfors",
      "year": "1987",
      "journal-title": "J. Immunol. Meth."
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib38",
      "doi-asserted-by": "crossref",
      "first-page": "55",
      "DOI": "10.1016/0169-328X(87)90044-1",
      "article-title": "Decreased levels of nerve growth factor (NGF) and its messenger RNA in the aged rat brain",
      "volume": "3",
      "author": "L\u00e4rkfors",
      "year": "1987",
      "journal-title": "Mol. Brain Res."
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib39",
      "doi-asserted-by": "crossref",
      "first-page": "1154",
      "DOI": "10.1126/science.3306916",
      "article-title": "The nerve growth factor 35 years later",
      "volume": "237",
      "author": "Levi-Montalcini",
      "year": "1987",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib40",
      "doi-asserted-by": "crossref",
      "first-page": "501",
      "DOI": "10.1016/0896-6273(90)90089-X",
      "article-title": "NT-3, BDNF, and NGF in the developing rat nervous system: parallel as well as reciprocal patterns of expression",
      "volume": "5",
      "author": "Maisonpierre",
      "year": "1990",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib41",
      "doi-asserted-by": "crossref",
      "first-page": "31",
      "DOI": "10.1016/0197-4580(91)90036-J",
      "article-title": "Postnatal handling attenuates certain neuroendocrine, anatomical, and cognitive dysfunctions associated with aging in female rats",
      "volume": "12",
      "author": "Meaney",
      "year": "1991",
      "journal-title": "Neurobiol. Aging."
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib42",
      "doi-asserted-by": "crossref",
      "first-page": "766",
      "DOI": "10.1126/science.3340858",
      "article-title": "Effect of neonatal handling on age-related impairments associated with the hippocampus",
      "volume": "239",
      "author": "Meany",
      "year": "1988",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib43",
      "doi-asserted-by": "crossref",
      "first-page": "129",
      "DOI": "10.1093/geronj/32.2.129",
      "article-title": "Aging-induced changes in acetylcholine and serotonin content of discrete brain nuclei",
      "volume": "32",
      "author": "Meek",
      "year": "1977",
      "journal-title": "J. Gerontol."
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib44",
      "doi-asserted-by": "crossref",
      "first-page": "143",
      "DOI": "10.1016/0197-4580(89)90023-7",
      "article-title": "Age-related differences in brain choline acetyltransferase, cholinesterase and muscarinic receptor sites in two strains of rats",
      "volume": "10",
      "author": "Michalek",
      "year": "1989",
      "journal-title": "Neurobiol. Aging."
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib45",
      "doi-asserted-by": "crossref",
      "first-page": "83",
      "DOI": "10.1016/0197-4580(92)90013-N",
      "article-title": "Persistent changes in behaviour and brain serotonin during aging in rats subjected to infant nasal viral infection",
      "volume": "13",
      "author": "Mohammed",
      "year": "1991",
      "journal-title": "Neurobiol. Aging"
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib46",
      "first-page": "285",
      "article-title": "Learning deficits in aged rats pretreated chronically with barbital and tested late in abstinence: alleviation by tetrahydroaminoacridine",
      "volume": "2",
      "author": "Mohammed",
      "year": "1990",
      "journal-title": "J. Neurotransm."
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib47",
      "doi-asserted-by": "crossref",
      "first-page": "62",
      "DOI": "10.1016/0006-8993(90)90195-H",
      "article-title": "Environmental influence on behaviour and nerve growth factor in the brain",
      "volume": "528",
      "author": "Mohammed",
      "year": "1990",
      "journal-title": "Brain Res."
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib48",
      "doi-asserted-by": "crossref",
      "first-page": "681",
      "DOI": "10.1038/297681a0",
      "article-title": "Place navigation impaired in rats with hippocampal lesions",
      "volume": "297",
      "author": "Morris",
      "year": "1978",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib49",
      "series-title": "The hippocampus as a cognitive map",
      "author": "O'Keefe",
      "year": "1978"
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib50",
      "doi-asserted-by": "crossref",
      "first-page": "313",
      "DOI": "10.1017/S0140525X00062713",
      "article-title": "Hippocampus, Space and Memory",
      "volume": "2",
      "author": "Olton",
      "year": "1979",
      "journal-title": "Behav. Brain Sci."
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib51",
      "doi-asserted-by": "crossref",
      "first-page": "57",
      "DOI": "10.1016/0306-4522(90)90304-M",
      "article-title": "Distribution of nerve growth factor receptor-like immunoreactivity in the adult rat central nervous system. Effect of colchicine and correlation with the cholinergic system",
      "volume": "34",
      "author": "Pioro",
      "year": "1990",
      "journal-title": "Neuroscience"
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib52",
      "doi-asserted-by": "crossref",
      "first-page": "593",
      "DOI": "10.1038/325593a0",
      "article-title": "Gene transfer and molecular cloning of the rat nerve growth factor receptor",
      "volume": "325",
      "author": "Radeke",
      "year": "1987",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib53",
      "doi-asserted-by": "crossref",
      "first-page": "2503",
      "DOI": "10.1016/0024-3205(88)90349-9",
      "article-title": "Changes in biogenic amines in rat hippocampus during development and aging",
      "volume": "42",
      "author": "Santiago",
      "year": "1988",
      "journal-title": "Life Sci."
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib54",
      "doi-asserted-by": "crossref",
      "first-page": "473",
      "DOI": "10.1016/0006-8993(79)90303-2",
      "article-title": "Nerve growth factor (NGF) in the rat CNS: absence for specific retrograde axonal transport and tyrosine hydroxylase induction in locus coeruleus and substantia nigra",
      "volume": "168",
      "author": "Schwab",
      "year": "1979",
      "journal-title": "Brain Res."
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib55",
      "doi-asserted-by": "crossref",
      "first-page": "33",
      "DOI": "10.1016/0006-8993(84)91338-6",
      "article-title": "Specific retrograde transport of nerve growth factor (NGF) from neocortex to nucleus basalis in the rat",
      "volume": "300",
      "author": "Seiler",
      "year": "1983",
      "journal-title": "Brain Res."
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib56",
      "doi-asserted-by": "crossref",
      "first-page": "665",
      "DOI": "10.1002/jnr.490270427",
      "article-title": "Recombinant human \u03b2-nerve growth factor (NGF): biological activity and properties in an enzyme immunoassay",
      "volume": "27",
      "author": "S\u00f6derstr\u00f6m",
      "year": "1990",
      "journal-title": "J. Neurosci. Res."
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib57",
      "doi-asserted-by": "crossref",
      "first-page": "338",
      "DOI": "10.1126/science.1688664",
      "article-title": "Survival of adult basal forebrain cholinergic neurons after loss of target neurons",
      "volume": "247",
      "author": "Sofroniew",
      "year": "1990",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib58",
      "series-title": "Neurobiology of the Hippocampus",
      "first-page": "491",
      "article-title": "The hippocampus and neuropsychology of memory",
      "author": "Squire",
      "year": "1985"
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib59",
      "first-page": "165",
      "article-title": "The changing face of neurotrophic factors",
      "volume": "14",
      "author": "Thoenen",
      "year": "1991",
      "journal-title": "Trends Pharmacol. Sci."
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib60",
      "doi-asserted-by": "crossref",
      "first-page": "1284",
      "DOI": "10.1152/physrev.1980.60.4.1284",
      "article-title": "Physiology of nerve growth factor",
      "volume": "60",
      "author": "Thoenen",
      "year": "1980",
      "journal-title": "Physiol. Rev."
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib61",
      "first-page": "593",
      "article-title": "Messenger RNAs for trk and the low-affinity NGF receptor in rat basal forebrain",
      "volume": "2",
      "author": "Vasquez",
      "year": "1991",
      "journal-title": "Neuro-Report"
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib62",
      "doi-asserted-by": "crossref",
      "first-page": "817",
      "DOI": "10.1073/pnas.83.3.817",
      "article-title": "Developmental and regional expression of \u03b2-nerve growth factor messenger RNA and protein in the rat central nervous system",
      "volume": "83",
      "author": "Whittemore",
      "year": "1986",
      "journal-title": "Proc. Natl. Acad. Sci. U.S.A."
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib63",
      "doi-asserted-by": "crossref",
      "first-page": "439",
      "DOI": "10.1016/0165-0173(87)90008-7",
      "article-title": "The expression, localization and functional significance of \u03b2-nerve growth factor in the central nervous system",
      "volume": "12",
      "author": "Whittemore",
      "year": "1987",
      "journal-title": "Brain Res. Rev."
    },
    {
      "key": "10.1016/S0166-4328(05)80134-2_bib64",
      "doi-asserted-by": "crossref",
      "first-page": "591",
      "DOI": "10.1007/BF00266747",
      "article-title": "Local cerebral glucose utilization in the brain of old learning impaired rats",
      "volume": "95",
      "author": "Wree",
      "year": "1991",
      "journal-title": "Histochemistry"
    }
  ],
  "container-title": "Behavioural Brain Research",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0166432805801342?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0166432805801342?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2019,
        4,
        22
      ]
    ],
    "date-time": "2019-04-22T12:18:07Z",
    "timestamp": 1555935487000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0166432805801342"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1992,
        5
      ]
    ]
  },
  "references-count": 64,
  "journal-issue": {
    "issue": "1",
    "published-print": {
      "date-parts": [
        [
          1992,
          5
        ]
      ]
    }
  },
  "alternative-id": [
    "S0166432805801342"
  ],
  "URL": "http://dx.doi.org/10.1016/S0166-4328(05)80134-2",
  "relation": {},
  "ISSN": [
    "0166-4328"
  ],
  "subject": [],
  "container-title-short": "Behavioural Brain Research",
  "published": {
    "date-parts": [
      [
        1992,
        5
      ]
    ]
  }
}