DOI: 10.1016/s0166-2236(99)01500-3. Is CREB a key to neuronal survival?

Is CREB a key to neuronal survival?

10.1016/s0166-2236(99)01500-3

Crossref journal-article

Elsevier BV

Trends in Neurosciences (78)

Bibliography

Walton, M. R., & Dragunow, M. (2000). Is CREB a key to neuronal survival? Trends in Neurosciences, 23(2), 48â53.

Authors 2

Marshall R Walton (first)
Mike Dragunow (additional)

References 61 Referenced 426

10.1016/0166-2236(95)94495-Q / Trends Neurosci. / Selective neuronal vulnerability in the hippocampus: a role for gene expression? by Schreiber (1995)
10.1016/S0149-7634(96)00010-3 / Neurosci. Biobehav. Rev. / Neuroprotective signal transduction: relevance to stroke by Mattson (1997)
10.1016/0092-8674(89)90013-5 / Cell / Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133 by Gonzalez (1989)
10.1074/jbc.273.31.19834 / J. Biol. Chem. / Hypoxia induces phosphorylation of the cyclic AMP response element-binding protein by a novel signaling mechanism by Beiter-Johnson (1998)
10.1038/364821a0 / Nature / Protein kinase A dependent activator in transcription factor CREB reveals new roles for CREM repressors by Brindle (1993)
10.1128/MCB.11.3.1306 / Mol. Cell. Biol. / Characterization of motifs which are critical for activity of the cyclic AMP responsive transcription factor CREB by Gonzalez (1991)
10.1038/365855a0 / Nature / Phosphorylated CREB binds specifically to the nuclear protein CBP by Chrivia (1993)
10.1038/370223a0 / Nature / Nuclear protein CBP is a co-activator for the transcription factor CREB by Kwok (1994)
10.1038/370226a0 / Nature / Activation of cyclic AMP and mitogen responsive genes relies on a common nuclear factor by Arias (1994)
10.1073/pnas.87.11.4320 / Proc. Natl. Acad. Sci. U. S. A. / Negative and positive regulation by transcription factor cAMP response element-binding protein is regulated by phosphorylation by Lamph (1990)
10.1016/S0021-9258(18)41694-8 / J. Biol. Chem. / Transcriptional cross-talk: nuclear factors CREM and CREB bind to AP-1 sites and inhibit activation by Jun by Masquilier (1992)
10.1074/jbc.271.24.14214 / J. Biol. Chem. / Neuronal activity increases the phosphorylation of the transcription factor cyclic AMP response element binding protein (CREB) in rat hippocampus and cortex by Moore (1996)
10.1016/0006-8993(94)90706-4 / Brain Res. / A developmental study of cyclic AMP-response element binding protein (CREB) by in situ hybridization histochemistry and immunocytochemistry in the rat neocortex by Imaki (1994)
10.1146/annurev.neuro.21.1.127 / Annu. Rev. Neurosci. / CREB and memory by Silva (1998)
10.1016/0165-0173(95)00003-L / Brain Res. Rev. / The role of inducible transcription factors in apoptotic nerve cell death by Dragunow (1995)
10.1016/0169-328X(94)00217-3 / Mol. Brain Res. / Mechanisms of delayed cell death following hypoxic-ischemic injury in the immature rat: evidence for apoptosis during selective neuronal loss by Beilharz (1995)
10.1016/S0165-0173(98)00053-8 / Brain Res. Rev. / Neuronal death and survival in two models of hypoxic–ischemic brain damage by Walton (1999)
10.1016/0169-328X(93)90101-T / Mol. Brain Res. / Is c-Jun involved in nerve cell death following status epilepticus and hypoxic–ischemic brain injury? by Dragunow (1993)
10.1016/S0169-328X(96)00144-1 / Mol. Brain Res. / The role of the cyclic AMP response element binding protein (CREB) in hypoxic-ischemic brain damage and repair by Walton (1996)
10.1016/S0306-4522(98)00352-2 / Neuroscience / Persistent phosphorylation of cyclic AMP responsive element binding protein and activating transcription factor 2 transcription factors following transient cerebral ischemia in rat brain by Hu (1999)
10.1016/S0006-8993(98)01263-3 / Brain Res. / Immunohistochemical analysis of cyclic AMP response element binding protein phosphorylation in focal cerebral ischemia by Tanaka (1999)
10.1016/S0169-328X(98)00275-7 / Mol. Brain Res. / ATF-2 phosphorylation in apoptotic neuronal death by Walton (1998)
10.1016/S0169-328X(99)00027-3 / Mol. Brain Res. / Inducible transcription factor expression in a cell culture model of apoptosis by Woodgate (1999)
10.1046/j.1471-4159.1999.01836.x / J. Neurochem. / CREB phosphorylation promotes nerve cell survival by Walton (1999)
{'key': '10.1016/S0166-2236(99)01500-3_BIB25', 'first-page': '2223', 'article-title': 'Expression of dominant negative CREB reduces resistance to radiation of human melanoma cells', 'volume': '12', 'author': 'Yang', 'year': '1996', 'journal-title': 'Oncogene'} / Oncogene / Expression of dominant negative CREB reduces resistance to radiation of human melanoma cells by Yang (1996)
10.1074/jbc.273.38.24884 / J. Biol. Chem. / CREB and its associated proteins act as survival factors for human melanoma cells by Jean (1998)
10.1038/379081a0 / Nature / Defective thymocyte proliferation and IL-2 production in transgenic mice expressing a dominant negative form of CREB by Barton (1996)
10.1016/S0171-2985(97)80049-6 / Immunobiology / Expression of transcription factor genes after influenza A virus infection by Bussfeld (1997)
10.1038/7449 / Nat. Med. / Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective by Young (1999)
10.1523/JNEUROSCI.13-06-02351.1993 / J. Neurosci. / Highly polysialylated neural cell adhesion molecule (NCAM-H) is expressed by newly generated granule cells in the dentate gyrus of the adult rat by Seki (1993)
10.1002/(SICI)1097-4695(199903)38:4<542::AID-NEU9>3.0.CO;2-1 / J. Neurobiol. / N-CAM stimulates the RAS-MAPK pathway and CREB phosphorylation in neuronal cells by Schmid (1999)
10.1016/S0006-8993(98)00309-6 / Brain Res. / Cross-linking of N-CAM receptors on neurons induces programmed cell death by Azizeh (1998)
10.1006/mcne.1995.1015 / Mol. Cell. Neurosci. / Serine-133 phosphorylated CREB induces transcription via a cooperative mechanism that may confer specificity to neurotrophin signals by Bonni (1995)
10.1016/S0896-6273(00)80395-5 / Neuron / CREB: a major mediator of neuronal neurotrophin responses by Finkbeiner (1997)
10.1016/S0896-6273(00)81011-9 / Neuron / Identification of a signaling pathway involved in calcium regulation of BDNF expression by Shieh (1998)
10.1016/S0896-6273(00)81010-7 / Neuron / Calcium influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism by Tao (1998)
10.1046/j.1471-4159.1996.66051836.x / J. Neurochem. / Estrogens attentuate and corticosterone exacerbates excitotoxicity, oxidative injury, and amyloid beta peptide toxicity in hippocampal neurons by Goodman (1996)
10.1523/JNEUROSCI.17-02-00511.1997 / J. Neurosci. / 17 beta estradiol exerts neuroprotective effects on SK-N-SH cells by Green (1997)
10.1523/JNEUROSCI.18-17-06672.1998 / J. Neurosci. / Transcriptional effects of estrogen on neurotensin gene expression involve cAMP/protein kinase A-dependent signaling mechanisms by Watters (1998)
10.1210/en.136.5.2320 / Endrocrinology / The effect of ovariectomy and estradiol replacement on brain derived neurotrophic factor messenger ribonucleic acid expression in cortical and hippocampal brain regions of female Sprague-Dawley rats by Singh (1995)
10.1089/dna.1997.16.323 / DNA Cell Biol. / PACAP type I receptor activation promotes cerebellar neuron survival through the cAMP/PKA signaling pathway by Campard (1997)
10.1002/(SICI)1097-4547(19981201)54:5<698::AID-JNR15>3.0.CO;2-5 / J. Neurosci. Res. / Neurotrophic and neuroprotective effects of pituitary adenylate cyclase-activating polypeptide (PACAP) on mesencephalic dopaminergic neurons by Takei (1998)
10.1016/S0167-0115(97)01038-0 / Regul. Pept. / Neuronal protection from apoptosis by pituitary adenylate cyclase-activating polypeptide by Tanaka (1997)
10.1523/JNEUROSCI.17-01-00083.1997 / J. Neurosci. / Pituitary adenylate cyclase-activating polypeptide (PACAP-38) protects cerebellar granule neurons from apoptosis by activating the mitogen-activated protein kinase (MAP kinase) pathway by Villalba (1997)
10.1002/(SICI)1096-9861(19960805)371:4<567::AID-CNE6>3.0.CO;2-2 / J. Comp. Neurol. / Distribution of the mRNA for a pituitary adenylate cyclase-activating polypeptide receptor in the rat brain: an in situ hybridization study by Hashimoto (1996)
10.1126/science.275.5300.661 / Science / Regulation of neuronal survival by the serine-threonine protein kinase Akt by Dudek (1997)
10.1016/S0092-8674(00)81883-8 / Cell / PI3K: Downstream AKTion blocks apoptosis by Franke (1997)
10.1128/MCB.17.3.1595 / Mol. Cell. Biol. / Antiapoptotic signaling by the insulin-like growth factor 1 receptor, phosphatidylinositol-3-kinase and AKT by Kulik (1997)
10.1016/S0092-8674(00)80405-5 / Cell / Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery by Datta (1997)
10.1126/science.278.5338.687 / Science / Interleukin 3-induced phosphorylation of BAD through the protein kinase Akt by del Peso (1997)
10.1126/science.282.5392.1318 / Science / Regulation of cell death protease caspase 9 by phosphorylation by Cardone (1998)
10.1074/jbc.273.49.32377 / J. Biol. Chem. / CREB is a regulatory target for the protein kinase Akt/PKB by Du (1998)
10.1038/25147 / Nature / Calcium promotes cell survival through CaM-K kinase activation of the protein kinase B pathway by Yano (1998)
10.1523/JNEUROSCI.19-11-04337.1999 / J. Neurosci. / The mitogen-activated protein kinase cascade couples PKA and PKC to cAMP response element binding protein phosphorylation in area CA1 of hippocampus by Roberson (1999)
10.1128/MCB.16.10.5546 / Mol. Cell. Biol. / Induction of bcl-2 expression by phosphorylated CREB proteins during B-cell activation and rescue from apoptosis by Wilson (1996)
10.1146/annurev.neuro.20.1.245 / Annu. Rev. Neurosci. / Bcl-2 gene family in the nervous system by Merry (1997)
10.1097/00004647-199701000-00002 / J. Cereb. Blood Flow Metab. / Apoptosis repressor genes bcl-2 and bcl-x-long are expressed in the rat brain following global ischemia by Chen (1997)
10.1128/MCB.19.9.6195 / Mol. Cell. Biol. / The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB by Wand (1999)
10.1074/jbc.274.5.2829 / J. Biol. Chem. / Insulin-like growth factor 1-mediated activation of the transcription factor cAMP response element-binding protein in PC12 cells by Pugazhenthi (1999)
10.1097/00004647-199812000-00007 / J. Cereb. Blood Flow Metab. / Attentuated c-fos mRNA induction after middle cerebral artery occlusion in CREB knock-out mice does not modulate focal ischemic injury by Hata (1998)
10.1126/science.286.5443.1358 / Science / Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms by Bonni (1999)

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 9:14 p.m.)
Deposited	1 year, 7 months ago (Jan. 1, 2024, 8:24 p.m.)
Indexed	1 month ago (July 25, 2025, 6:37 a.m.)
Issued	25 years, 6 months ago (Feb. 1, 2000)
Published	25 years, 6 months ago (Feb. 1, 2000)
Published Print	25 years, 6 months ago (Feb. 1, 2000)

Funders 0

None

BibTeX

@article{Walton_2000, title={Is CREB a key to neuronal survival?}, volume={23}, ISSN={0166-2236}, url={http://dx.doi.org/10.1016/s0166-2236(99)01500-3}, DOI={10.1016/s0166-2236(99)01500-3}, number={2}, journal={Trends in Neurosciences}, publisher={Elsevier BV}, author={Walton, Marshall R and Dragunow, Mike}, year={2000}, month=feb, pages={48–53} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        25
      ]
    ],
    "date-time": "2025-07-25T10:37:34Z",
    "timestamp": 1753439854864
  },
  "reference-count": 61,
  "publisher": "Elsevier BV",
  "issue": "2",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2000,
            2,
            1
          ]
        ],
        "date-time": "2000-02-01T00:00:00Z",
        "timestamp": 949363200000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2000,
        2
      ]
    ]
  },
  "DOI": "10.1016/s0166-2236(99)01500-3",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        7,
        26
      ]
    ],
    "date-time": "2002-07-26T01:14:54Z",
    "timestamp": 1027646094000
  },
  "page": "48-53",
  "source": "Crossref",
  "is-referenced-by-count": 426,
  "title": "Is CREB a key to neuronal survival?",
  "prefix": "10.1016",
  "volume": "23",
  "author": [
    {
      "given": "Marshall R",
      "family": "Walton",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Mike",
      "family": "Dragunow",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB1",
      "doi-asserted-by": "crossref",
      "first-page": "446",
      "DOI": "10.1016/0166-2236(95)94495-Q",
      "article-title": "Selective neuronal vulnerability in the hippocampus: a role for gene expression?",
      "volume": "18",
      "author": "Schreiber",
      "year": "1995",
      "journal-title": "Trends Neurosci."
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "193",
      "DOI": "10.1016/S0149-7634(96)00010-3",
      "article-title": "Neuroprotective signal transduction: relevance to stroke",
      "volume": "21",
      "author": "Mattson",
      "year": "1997",
      "journal-title": "Neurosci. Biobehav. Rev."
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "675",
      "DOI": "10.1016/0092-8674(89)90013-5",
      "article-title": "Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133",
      "volume": "59",
      "author": "Gonzalez",
      "year": "1989",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB4",
      "doi-asserted-by": "crossref",
      "first-page": "19834",
      "DOI": "10.1074/jbc.273.31.19834",
      "article-title": "Hypoxia induces phosphorylation of the cyclic AMP response element-binding protein by a novel signaling mechanism",
      "volume": "273",
      "author": "Beiter-Johnson",
      "year": "1998",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB5",
      "doi-asserted-by": "crossref",
      "first-page": "821",
      "DOI": "10.1038/364821a0",
      "article-title": "Protein kinase A dependent activator in transcription factor CREB reveals new roles for CREM repressors",
      "volume": "364",
      "author": "Brindle",
      "year": "1993",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "1306",
      "DOI": "10.1128/MCB.11.3.1306",
      "article-title": "Characterization of motifs which are critical for activity of the cyclic AMP responsive transcription factor CREB",
      "volume": "11",
      "author": "Gonzalez",
      "year": "1991",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "855",
      "DOI": "10.1038/365855a0",
      "article-title": "Phosphorylated CREB binds specifically to the nuclear protein CBP",
      "volume": "365",
      "author": "Chrivia",
      "year": "1993",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB8",
      "doi-asserted-by": "crossref",
      "first-page": "223",
      "DOI": "10.1038/370223a0",
      "article-title": "Nuclear protein CBP is a co-activator for the transcription factor CREB",
      "volume": "370",
      "author": "Kwok",
      "year": "1994",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "226",
      "DOI": "10.1038/370226a0",
      "article-title": "Activation of cyclic AMP and mitogen responsive genes relies on a common nuclear factor",
      "volume": "370",
      "author": "Arias",
      "year": "1994",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "4320",
      "DOI": "10.1073/pnas.87.11.4320",
      "article-title": "Negative and positive regulation by transcription factor cAMP response element-binding protein is regulated by phosphorylation",
      "volume": "87",
      "author": "Lamph",
      "year": "1990",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB11",
      "doi-asserted-by": "crossref",
      "first-page": "22460",
      "DOI": "10.1016/S0021-9258(18)41694-8",
      "article-title": "Transcriptional cross-talk: nuclear factors CREM and CREB bind to AP-1 sites and inhibit activation by Jun",
      "volume": "267",
      "author": "Masquilier",
      "year": "1992",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "14214",
      "DOI": "10.1074/jbc.271.24.14214",
      "article-title": "Neuronal activity increases the phosphorylation of the transcription factor cyclic AMP response element binding protein (CREB) in rat hippocampus and cortex",
      "volume": "271",
      "author": "Moore",
      "year": "1996",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "269",
      "DOI": "10.1016/0006-8993(94)90706-4",
      "article-title": "A developmental study of cyclic AMP-response element binding protein (CREB) by in situ hybridization histochemistry and immunocytochemistry in the rat neocortex",
      "volume": "651",
      "author": "Imaki",
      "year": "1994",
      "journal-title": "Brain Res."
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "127",
      "DOI": "10.1146/annurev.neuro.21.1.127",
      "article-title": "CREB and memory",
      "volume": "21",
      "author": "Silva",
      "year": "1998",
      "journal-title": "Annu. Rev. Neurosci."
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1016/0165-0173(95)00003-L",
      "article-title": "The role of inducible transcription factors in apoptotic nerve cell death",
      "volume": "21",
      "author": "Dragunow",
      "year": "1995",
      "journal-title": "Brain Res. Rev."
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1016/0169-328X(94)00217-3",
      "article-title": "Mechanisms of delayed cell death following hypoxic-ischemic injury in the immature rat: evidence for apoptosis during selective neuronal loss",
      "volume": "29",
      "author": "Beilharz",
      "year": "1995",
      "journal-title": "Mol. Brain Res."
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "137",
      "DOI": "10.1016/S0165-0173(98)00053-8",
      "article-title": "Neuronal death and survival in two models of hypoxic\u2013ischemic brain damage",
      "volume": "29",
      "author": "Walton",
      "year": "1999",
      "journal-title": "Brain Res. Rev."
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "347",
      "DOI": "10.1016/0169-328X(93)90101-T",
      "article-title": "Is c-Jun involved in nerve cell death following status epilepticus and hypoxic\u2013ischemic brain injury?",
      "volume": "18",
      "author": "Dragunow",
      "year": "1993",
      "journal-title": "Mol. Brain Res."
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "21",
      "DOI": "10.1016/S0169-328X(96)00144-1",
      "article-title": "The role of the cyclic AMP response element binding protein (CREB) in hypoxic-ischemic brain damage and repair",
      "volume": "43",
      "author": "Walton",
      "year": "1996",
      "journal-title": "Mol. Brain Res."
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "437",
      "DOI": "10.1016/S0306-4522(98)00352-2",
      "article-title": "Persistent phosphorylation of cyclic AMP responsive element binding protein and activating transcription factor 2 transcription factors following transient cerebral ischemia in rat brain",
      "volume": "89",
      "author": "Hu",
      "year": "1999",
      "journal-title": "Neuroscience"
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB21",
      "doi-asserted-by": "crossref",
      "first-page": "520",
      "DOI": "10.1016/S0006-8993(98)01263-3",
      "article-title": "Immunohistochemical analysis of cyclic AMP response element binding protein phosphorylation in focal cerebral ischemia",
      "volume": "818",
      "author": "Tanaka",
      "year": "1999",
      "journal-title": "Brain Res."
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "198",
      "DOI": "10.1016/S0169-328X(98)00275-7",
      "article-title": "ATF-2 phosphorylation in apoptotic neuronal death",
      "volume": "63",
      "author": "Walton",
      "year": "1998",
      "journal-title": "Mol. Brain Res."
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "211",
      "DOI": "10.1016/S0169-328X(99)00027-3",
      "article-title": "Inducible transcription factor expression in a cell culture model of apoptosis",
      "volume": "66",
      "author": "Woodgate",
      "year": "1999",
      "journal-title": "Mol. Brain Res."
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "1836",
      "DOI": "10.1046/j.1471-4159.1999.01836.x",
      "article-title": "CREB phosphorylation promotes nerve cell survival",
      "volume": "73",
      "author": "Walton",
      "year": "1999",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB25",
      "first-page": "2223",
      "article-title": "Expression of dominant negative CREB reduces resistance to radiation of human melanoma cells",
      "volume": "12",
      "author": "Yang",
      "year": "1996",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB26",
      "doi-asserted-by": "crossref",
      "first-page": "24884",
      "DOI": "10.1074/jbc.273.38.24884",
      "article-title": "CREB and its associated proteins act as survival factors for human melanoma cells",
      "volume": "273",
      "author": "Jean",
      "year": "1998",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB27",
      "doi-asserted-by": "crossref",
      "first-page": "81",
      "DOI": "10.1038/379081a0",
      "article-title": "Defective thymocyte proliferation and IL-2 production in transgenic mice expressing a dominant negative form of CREB",
      "volume": "379",
      "author": "Barton",
      "year": "1996",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "291",
      "DOI": "10.1016/S0171-2985(97)80049-6",
      "article-title": "Expression of transcription factor genes after influenza A virus infection",
      "volume": "198",
      "author": "Bussfeld",
      "year": "1997",
      "journal-title": "Immunobiology"
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "448",
      "DOI": "10.1038/7449",
      "article-title": "Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective",
      "volume": "5",
      "author": "Young",
      "year": "1999",
      "journal-title": "Nat. Med."
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "2351",
      "DOI": "10.1523/JNEUROSCI.13-06-02351.1993",
      "article-title": "Highly polysialylated neural cell adhesion molecule (NCAM-H) is expressed by newly generated granule cells in the dentate gyrus of the adult rat",
      "volume": "13",
      "author": "Seki",
      "year": "1993",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "542",
      "DOI": "10.1002/(SICI)1097-4695(199903)38:4<542::AID-NEU9>3.0.CO;2-1",
      "article-title": "N-CAM stimulates the RAS-MAPK pathway and CREB phosphorylation in neuronal cells",
      "volume": "38",
      "author": "Schmid",
      "year": "1999",
      "journal-title": "J. Neurobiol."
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "20",
      "DOI": "10.1016/S0006-8993(98)00309-6",
      "article-title": "Cross-linking of N-CAM receptors on neurons induces programmed cell death",
      "volume": "796",
      "author": "Azizeh",
      "year": "1998",
      "journal-title": "Brain Res."
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "168",
      "DOI": "10.1006/mcne.1995.1015",
      "article-title": "Serine-133 phosphorylated CREB induces transcription via a cooperative mechanism that may confer specificity to neurotrophin signals",
      "volume": "6",
      "author": "Bonni",
      "year": "1995",
      "journal-title": "Mol. Cell. Neurosci."
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "1031",
      "DOI": "10.1016/S0896-6273(00)80395-5",
      "article-title": "CREB: a major mediator of neuronal neurotrophin responses",
      "volume": "19",
      "author": "Finkbeiner",
      "year": "1997",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "727",
      "DOI": "10.1016/S0896-6273(00)81011-9",
      "article-title": "Identification of a signaling pathway involved in calcium regulation of BDNF expression",
      "volume": "20",
      "author": "Shieh",
      "year": "1998",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB36",
      "doi-asserted-by": "crossref",
      "first-page": "709",
      "DOI": "10.1016/S0896-6273(00)81010-7",
      "article-title": "Calcium influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism",
      "volume": "20",
      "author": "Tao",
      "year": "1998",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB37",
      "doi-asserted-by": "crossref",
      "first-page": "1836",
      "DOI": "10.1046/j.1471-4159.1996.66051836.x",
      "article-title": "Estrogens attentuate and corticosterone exacerbates excitotoxicity, oxidative injury, and amyloid beta peptide toxicity in hippocampal neurons",
      "volume": "66",
      "author": "Goodman",
      "year": "1996",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB38",
      "doi-asserted-by": "crossref",
      "first-page": "511",
      "DOI": "10.1523/JNEUROSCI.17-02-00511.1997",
      "article-title": "17 beta estradiol exerts neuroprotective effects on SK-N-SH cells",
      "volume": "17",
      "author": "Green",
      "year": "1997",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB39",
      "doi-asserted-by": "crossref",
      "first-page": "6672",
      "DOI": "10.1523/JNEUROSCI.18-17-06672.1998",
      "article-title": "Transcriptional effects of estrogen on neurotensin gene expression involve cAMP/protein kinase A-dependent signaling mechanisms",
      "volume": "18",
      "author": "Watters",
      "year": "1998",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "2320",
      "DOI": "10.1210/en.136.5.2320",
      "article-title": "The effect of ovariectomy and estradiol replacement on brain derived neurotrophic factor messenger ribonucleic acid expression in cortical and hippocampal brain regions of female Sprague-Dawley rats",
      "volume": "136",
      "author": "Singh",
      "year": "1995",
      "journal-title": "Endrocrinology"
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB41",
      "doi-asserted-by": "crossref",
      "first-page": "323",
      "DOI": "10.1089/dna.1997.16.323",
      "article-title": "PACAP type I receptor activation promotes cerebellar neuron survival through the cAMP/PKA signaling pathway",
      "volume": "16",
      "author": "Campard",
      "year": "1997",
      "journal-title": "DNA Cell Biol."
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB42",
      "doi-asserted-by": "crossref",
      "first-page": "698",
      "DOI": "10.1002/(SICI)1097-4547(19981201)54:5<698::AID-JNR15>3.0.CO;2-5",
      "article-title": "Neurotrophic and neuroprotective effects of pituitary adenylate cyclase-activating polypeptide (PACAP) on mesencephalic dopaminergic neurons",
      "volume": "54",
      "author": "Takei",
      "year": "1998",
      "journal-title": "J. Neurosci. Res."
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB43",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1016/S0167-0115(97)01038-0",
      "article-title": "Neuronal protection from apoptosis by pituitary adenylate cyclase-activating polypeptide",
      "volume": "72",
      "author": "Tanaka",
      "year": "1997",
      "journal-title": "Regul. Pept."
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB44",
      "doi-asserted-by": "crossref",
      "first-page": "83",
      "DOI": "10.1523/JNEUROSCI.17-01-00083.1997",
      "article-title": "Pituitary adenylate cyclase-activating polypeptide (PACAP-38) protects cerebellar granule neurons from apoptosis by activating the mitogen-activated protein kinase (MAP kinase) pathway",
      "volume": "17",
      "author": "Villalba",
      "year": "1997",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB45",
      "doi-asserted-by": "crossref",
      "first-page": "567",
      "DOI": "10.1002/(SICI)1096-9861(19960805)371:4<567::AID-CNE6>3.0.CO;2-2",
      "article-title": "Distribution of the mRNA for a pituitary adenylate cyclase-activating polypeptide receptor in the rat brain: an in situ hybridization study",
      "volume": "371",
      "author": "Hashimoto",
      "year": "1996",
      "journal-title": "J. Comp. Neurol."
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB46",
      "doi-asserted-by": "crossref",
      "first-page": "661",
      "DOI": "10.1126/science.275.5300.661",
      "article-title": "Regulation of neuronal survival by the serine-threonine protein kinase Akt",
      "volume": "275",
      "author": "Dudek",
      "year": "1997",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB47",
      "doi-asserted-by": "crossref",
      "first-page": "435",
      "DOI": "10.1016/S0092-8674(00)81883-8",
      "article-title": "PI3K: Downstream AKTion blocks apoptosis",
      "volume": "88",
      "author": "Franke",
      "year": "1997",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB48",
      "doi-asserted-by": "crossref",
      "first-page": "1595",
      "DOI": "10.1128/MCB.17.3.1595",
      "article-title": "Antiapoptotic signaling by the insulin-like growth factor 1 receptor, phosphatidylinositol-3-kinase and AKT",
      "volume": "17",
      "author": "Kulik",
      "year": "1997",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB49",
      "doi-asserted-by": "crossref",
      "first-page": "231",
      "DOI": "10.1016/S0092-8674(00)80405-5",
      "article-title": "Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery",
      "volume": "91",
      "author": "Datta",
      "year": "1997",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB50",
      "doi-asserted-by": "crossref",
      "first-page": "687",
      "DOI": "10.1126/science.278.5338.687",
      "article-title": "Interleukin 3-induced phosphorylation of BAD through the protein kinase Akt",
      "volume": "278",
      "author": "del Peso",
      "year": "1997",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB51",
      "doi-asserted-by": "crossref",
      "first-page": "1318",
      "DOI": "10.1126/science.282.5392.1318",
      "article-title": "Regulation of cell death protease caspase 9 by phosphorylation",
      "volume": "282",
      "author": "Cardone",
      "year": "1998",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB52",
      "doi-asserted-by": "crossref",
      "first-page": "32377",
      "DOI": "10.1074/jbc.273.49.32377",
      "article-title": "CREB is a regulatory target for the protein kinase Akt/PKB",
      "volume": "273",
      "author": "Du",
      "year": "1998",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB53",
      "doi-asserted-by": "crossref",
      "first-page": "584",
      "DOI": "10.1038/25147",
      "article-title": "Calcium promotes cell survival through CaM-K kinase activation of the protein kinase B pathway",
      "volume": "396",
      "author": "Yano",
      "year": "1998",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB54",
      "doi-asserted-by": "crossref",
      "first-page": "4337",
      "DOI": "10.1523/JNEUROSCI.19-11-04337.1999",
      "article-title": "The mitogen-activated protein kinase cascade couples PKA and PKC to cAMP response element binding protein phosphorylation in area CA1 of hippocampus",
      "volume": "19",
      "author": "Roberson",
      "year": "1999",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB55",
      "doi-asserted-by": "crossref",
      "first-page": "5546",
      "DOI": "10.1128/MCB.16.10.5546",
      "article-title": "Induction of bcl-2 expression by phosphorylated CREB proteins during B-cell activation and rescue from apoptosis",
      "volume": "16",
      "author": "Wilson",
      "year": "1996",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB56",
      "doi-asserted-by": "crossref",
      "first-page": "245",
      "DOI": "10.1146/annurev.neuro.20.1.245",
      "article-title": "Bcl-2 gene family in the nervous system",
      "volume": "20",
      "author": "Merry",
      "year": "1997",
      "journal-title": "Annu. Rev. Neurosci."
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB57",
      "doi-asserted-by": "crossref",
      "first-page": "2",
      "DOI": "10.1097/00004647-199701000-00002",
      "article-title": "Apoptosis repressor genes bcl-2 and bcl-x-long are expressed in the rat brain following global ischemia",
      "volume": "17",
      "author": "Chen",
      "year": "1997",
      "journal-title": "J. Cereb. Blood Flow Metab."
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB58",
      "doi-asserted-by": "crossref",
      "first-page": "6195",
      "DOI": "10.1128/MCB.19.9.6195",
      "article-title": "The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB",
      "volume": "19",
      "author": "Wand",
      "year": "1999",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB59",
      "doi-asserted-by": "crossref",
      "first-page": "2829",
      "DOI": "10.1074/jbc.274.5.2829",
      "article-title": "Insulin-like growth factor 1-mediated activation of the transcription factor cAMP response element-binding protein in PC12 cells",
      "volume": "274",
      "author": "Pugazhenthi",
      "year": "1999",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB60",
      "doi-asserted-by": "crossref",
      "first-page": "1325",
      "DOI": "10.1097/00004647-199812000-00007",
      "article-title": "Attentuated c-fos mRNA induction after middle cerebral artery occlusion in CREB knock-out mice does not modulate focal ischemic injury",
      "volume": "18",
      "author": "Hata",
      "year": "1998",
      "journal-title": "J. Cereb. Blood Flow Metab."
    },
    {
      "key": "10.1016/S0166-2236(99)01500-3_BIB61",
      "doi-asserted-by": "crossref",
      "first-page": "1358",
      "DOI": "10.1126/science.286.5443.1358",
      "article-title": "Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms",
      "volume": "286",
      "author": "Bonni",
      "year": "1999",
      "journal-title": "Science"
    }
  ],
  "container-title": "Trends in Neurosciences",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0166223699015003?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0166223699015003?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2024,
        1,
        2
      ]
    ],
    "date-time": "2024-01-02T01:24:21Z",
    "timestamp": 1704158661000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0166223699015003"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2000,
        2
      ]
    ]
  },
  "references-count": 61,
  "journal-issue": {
    "issue": "2",
    "published-print": {
      "date-parts": [
        [
          2000,
          2
        ]
      ]
    }
  },
  "alternative-id": [
    "S0166223699015003"
  ],
  "URL": "http://dx.doi.org/10.1016/S0166-2236(99)01500-3",
  "relation": {},
  "ISSN": [
    "0166-2236"
  ],
  "subject": [],
  "container-title-short": "Trends in Neurosciences",
  "published": {
    "date-parts": [
      [
        2000,
        2
      ]
    ]
  }
}