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Trends in Neurosciences (78)
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Gingrich, M. B., & Traynelis, S. F. (2000). Serine proteases and brain damage – is there a link? Trends in Neurosciences, 23(9), 399–407.

Authors 2
  1. Melissa B. Gingrich (first)
  2. Stephen F. Traynelis (additional)
References 85 Referenced 223
  1. 10.1016/0092-8674(91)90261-V / Cell / Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation by Vu (1991)
  2. 10.1073/pnas.91.20.9208 / Proc. Natl. Acad. Sci U. S. A. / Molecular cloning of a potential novel proteinase activated receptor by Nystedt (1994)
  3. 10.1038/386502a0 / Nature / Protease-activated receptor 3 is a second thrombin receptor in humans by Ishihara (1997)
  4. 10.1038/29325 / Nature / A dual thrombin receptor system for platelet activation by Kahn (1998)
  5. 10.1073/pnas.95.12.6642 / Proc. Natl. Acad. Sci U. S. A. / Cloning and characterization of human protease-activated receptor 4 by Xu (1998)
  6. 10.1074/jbc.273.36.23290 / J. Biol. Chem. / Gene and locus structure and chromosomal localization of the protease-activated receptor gene family by Kahn (1998)
  7. 10.1038/353674a0 / Nature / Domains specifying thrombin-receptor interaction by Vu (1991)
  8. 10.1042/bj3130353 / Biochem. J. / Cellular consequences of thrombin-receptor activation by Grand (1996)
  9. 10.1152/ajpcell.1998.274.6.C1429 / Am. J. Physiol. / Proteinase-activated receptors: novel mechanisms of signaling by serine proteases by Dery (1998)
  10. 10.1016/S0021-9258(17)33970-4 / J. Biol. Chem. / Thrombin receptor activation by Chen (1994)
  11. 10.1021/bi9824792 / Biochemistry / Plasmin desensitization of the PAR1 thrombin receptor: kinetics, sites of truncation, and implications for thrombolytic therapy by Kuliopulos (1999)
  12. 10.1139/cjpp-75-7-832 / Can. J. Physiol. Pharmacol. / Proteinase-activated receptors: structural requirements for activity, receptor cross-reactivity, and receptor selectivity of receptor-activating peptides by Hollenberg (1997)
  13. 10.1016/S0006-8993(97)00311-9 / Brain Res. / Thrombin receptor on rat primary hippocampal neurons: coupled calcium and cAMP responses by Yang (1997)
  14. 10.1523/JNEUROSCI.20-12-04582.2000 / J. Neurosci. / Potentiation of NMDA receptor function by the serine protease thrombin by Gingrich (2000)
  15. 10.1055/s-2007-1003563 / Semin. Throm. Hemostasis / Activation of cyclic nucleotide formation in neuroblastoma cells by Snider (1986)
  16. 10.1046/j.1471-4159.1995.64020583.x / J. Neurochem. / Thrombin receptor activation stimulates astrocyte proliferation and reversal of stellation by distinct pathways: involvement of tyrosine phosphorylation by Grabham (1995)
  17. 10.1523/JNEUROSCI.17-14-05316.1997 / J. Neurosci. / Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities by Donovan (1997)
  18. 10.1016/S0021-9258(17)42032-1 / J. Biol. Chem / Changes in the structure and function of the human thrombin receptor during receptor activation, internalization, and recycling by Brass (1994)
  19. 10.1016/S0021-9258(17)42230-7 / J. Biol. Chem. / Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase by Ishii (1994)
  20. 10.1016/S0165-0173(97)00015-5 / Brain Res. Rev. / The role of thrombin-like proteases in the development, plasticity, and pathology of the nervous system by Turgeon (1997)
  21. 10.1046/j.1471-4159.1998.71031034.x / J. Neurochem. / Injury-related factors and conditions down-regulate the thrombin receptor (PAR-1) in a human neuronal cell line by Weinstein (1998)
  22. 10.1021/bi982527i / Biochemistry / Protease-activated receptor-1 can mediate responses to SFLLRN in thrombin-desensitized cells: evidence for a novel mechanism for preventing or terminating signaling by PAR1’s tethered ligand by Hammes (1999)
  23. 10.1523/JNEUROSCI.15-04-02906.1995 / J. Neurosci. / Cellular localization of thrombin receptor mRNA in rat brain: expression by mesencephalic dopaminergic neurons and codistribution with prothrombin mRNA by Weinstein (1995)
  24. 10.1046/j.1460-9568.1998.00183.x / Eur. J. Neurosci. / Changes in the expression of protease-activated receptor 1 and protease nexin-1 mRNA during rat nervous system development and after nerve lesion by Niclou (1998)
  25. 10.1016/0896-6273(91)90060-D / Neuron / Prothrombin mRNA is expressed by cells of the nervous system by Dihanich
  26. 10.1046/j.1471-4159.1997.69051890.x / J. Neurochem. / Protease-activated receptor-2 (PAR-2) is present in the rat hippocampus and is associated with neurodegeneration by Smith-Swintosky (1997)
  27. 10.1046/j.1471-4159.1999.0720980.x / J. Neurochem. / Mechanism of thrombin clearance by human astrocytoma cells by Mentz (1999)
  28. {'key': '10.1016/S0166-2236(00)01617-9_BIB28', 'first-page': '741', 'article-title': 'Protease nexin-1: localization in the human brain suggests a protective role against extravasated serine proteases', 'volume': '137', 'author': 'Choi', 'year': '1990', 'journal-title': 'Am. J. Pathol.'} / Am. J. Pathol. / Protease nexin-1: localization in the human brain suggests a protective role against extravasated serine proteases by Choi (1990)
  29. 10.1002/(SICI)1097-4695(199606)30:2<255::AID-NEU7>3.0.CO;2-4 / J. Neurobiol. / Prevention of activity-dependent neuronal death: vasoactive intestinal polypeptide stimulates astrocytes to secrete the thrombin-inhibiting neurotrophic serpin, protease nexin-1 by Festoff (1996)
  30. 10.1523/JNEUROSCI.15-08-05840.1995 / J. Neurosci. / Protease nexin-1 and thrombin modulate neuronal Ca2+ homeostasis and sensitivity to glucose deprivation-induced injury by Smith-Swintosky (1995)
  31. 10.1016/0306-4522(92)90105-B / Neuroscience / The prolonged presence of glia-derived nexin, an endogenous protease inhibitor, in the hippocampus after ischemia-induced delayed neuronal death by Hoffman (1992)
  32. 10.1161/01.STR.23.8.1181 / Stroke / Thrombin activity in cerebrospinal fluid after subarachnoid hemorrhage by Suzuki (1992)
  33. 10.3171/jns.1996.84.1.0091 / J. Neurosurg. / Edema from intracerebral hemorrhage: the role of thrombin by Lee (1996)
  34. {'key': '10.1016/S0166-2236(00)01617-9_BIB34', 'series-title': 'Goodman & Gilman’s The Pharmacological Basis of Therapeutics', 'first-page': '1341', 'article-title': 'Anticoagulant, thrombolytic, and antiplatelet drugs', 'author': 'Majerus', 'year': '1996'} / Goodman & Gilman’s The Pharmacological Basis of Therapeutics / Anticoagulant, thrombolytic, and antiplatelet drugs by Majerus (1996)
  35. 10.3171/jns.1996.85.2.0335 / J. Neurosurg. / Thrombin-soaked gelatin sponge and brain edema in rats by Colon (1996)
  36. 10.1038/nm0298-228 / Nat. Med. / Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice by Wang (1998)
  37. 10.1038/nm0298-148 / Nat. Med. / tPA: a neuron buster too? by Del Zoppo (1998)
  38. 10.1097/00001721-199809000-00003 / Blood Coag. Fibrinolysis / Perturbation of the integrity of the blood–brain barrier by fibrinolytic enzymes by Nagy (1998)
  39. 10.1073/pnas.85.10.3440 / Proc. Natl. Acad. Sci. U. S. A. / Thrombin modulates and reverses neuroblastoma neurite outgrowth by Gurwitz (1988)
  40. 10.1016/0896-6273(92)90302-T / Neuron / Thrombin causes neurite retraction in neuronal cells through activation of cell surface receptors by Suidan (1992)
  41. 10.1523/JNEUROSCI.18-17-06882.1998 / J. Neurosci. / Thrombin perturbs neurite outgrowth and induces apoptotic cell death in enriched chick spinal motoneuron cultures through caspase activation by Turgeon (1998)
  42. 10.1016/0736-5748(93)90081-N / Int. J. Dev. Neurosci. / Microglia-derived plasminogen enhances neurite outgrowth from explant cultures of rat brain by Nagata (1993)
  43. 10.1016/S0896-6273(00)80597-8 / Neuron / Tissue plasminogen activator contributes to the late phase of LTP and to synaptic growth in the hippocampal mossy fiber pathway by Baranes (1998)
  44. 10.1073/pnas.91.22.10300 / Proc. Natl. Acad. Sci. U. S. A. / Proteolytic action of thrombin is required for electrical activity-dependent synapse reduction by Liu (1994)
  45. 10.1016/S0306-4522(97)00317-5 / Neuroscience / Involvement of protease-activated receptor-1 in the in vitro development of mesencephalic dopaminergic neurons by Debeir (1998)
  46. 10.1111/j.1471-4159.1990.tb01228.x / J. Neurochem. / Reciprocal modulation of astrocyte stellation by thrombin and protease nexin-1 by Cavanaugh (1990)
  47. 10.1046/j.1471-4159.1996.66062320.x / J. Neurochem. / Transduction mechanisms involved in thrombin receptor-induced nerve growth factor secretion and cell division in primary cultures of astrocytes by Debeir (1996)
  48. 10.1523/JNEUROSCI.20-07-02543.2000 / J. Neurosci. / Thrombomodulin as a new marker of lesion-induced astrogliosis: involvement of thrombin through the G-protein-coupled protease-activated receptor-1 by Pindon (2000)
  49. 10.1089/neu.1993.10.167 / J. Neurotrauma / Thrombin may contribute to the pathophysiology of central nervous injury by Nishino (1993)
  50. 10.1089/neu.1997.14.747 / J. Neurotrauma / Hirudin suppresses the invasion of inflammatory cells and the appearence of vimentin-positive astrocytes in the rat cerebral ablation model by Motohashi (1997)
  51. 10.1161/01.STR.29.12.2580 / Stroke / Role of blood clot formation on early edema development after experimental intracerebral hemorrhage by Xi (1998)
  52. 10.1161/01.STR.29.6.1202 / Stroke / Plasminogen activators potentiate thrombin-induced brain injury by Figueroa (1998)
  53. 10.1523/JNEUROSCI.15-07-05389.1995 / J. Neurosci. / Thrombin receptor activation protects neurons and astrocytes from cell death produced by environmental insults by Vaughan (1995)
  54. 10.1073/pnas.040552897 / Proc. Natl. Acad. Sci. U. S. A. / The protease thrombin is an endogenous mediator of hippocampal neuroprotection against ischemia at low concentrations but causes degeneration at high concentrations by Striggow (2000)
  55. 10.1097/00005072-199905000-00009 / J. Neuropathol. Exp. Neurol. / Activation of the protease-activated thrombin receptor (PAR)-1 induces motoneuron degeneration in the developing avian embryo by Turgeon (1999)
  56. 10.1111/j.1528-1157.1990.tb05861.x / Epilepsia / Post-traumatic epilepsy: cellular mechanisms and implications for treatment by Willmore (1990)
  57. 10.3171/jns.1992.76.3.0435 / J. Neurosurg. / Early seizures after mild closed head injury by Lee (1992)
  58. 10.1056/NEJM199801013380104 / N. Engl. J. Med. / A population-based study of seizures after traumatic brain injuries by Annegers (1998)
  59. 10.1212/WNL.38.9.1363 / Neurology / Early seizures following intracerebral hemorrhage by Berger (1988)
  60. 10.1212/WNL.39.8.1089 / Neurology / Seizures after primary intracerebral hemorrhage by Faught (1989)
  61. 10.1111/j.1528-1157.1993.tb02386.x / Epilepsia / Risk factors for developing seizures after a stroke by Lancman (1993)
  62. 10.1161/01.STR.28.8.1590 / Stroke / Predictive factors of early seizures after acute cerebrovascular disease by Arboix (1997)
  63. 10.3171/jns.1997.87.1.0073 / J. Neurosurg. / Seizures induced by intracerebral injection of thrombin: a model of intracerebral hemorrhage by Lee (1997)
  64. 10.1126/science.96527 / Science / Chronic focal epileptiform discharge induced by injection of iron into rat and cat cortex by Willmore (1978)
  65. 10.1038/nm0997-957 / Nat. Med. / Epilepsy and the too-well-connected brain by Prince (1997)
  66. 10.1016/S0006-8993(97)00338-7 / Brain Res. / Postsynaptic blockade of inhibitory postsynaptic currents by plasmin in CA1 pyramidal cells of rat hippocampal slices by Mizutani (1997)
  67. 10.1523/JNEUROSCI.17-12-04688.1997 / J. Neurosci. / Endogenous serine protease inhibitor modulates epileptic activity and hippocampal long term potentiation by Luthi (1997)
  68. 10.1038/361453a0 / Nature / Tissue-plasminogen activator is induced as an immediate-early gene during seizure, kindling, and long term potentiation by Qian (1993)
  69. 10.1523/JNEUROSCI.20-02-00542.2000 / J. Neurosci. / Role of tissue plasminogen activator receptor LRP in hippocampal long-term potentiation by Zhuo (2000)
  70. 10.1007/s001090050119 / J. Mol. Med. / Clinical implications of the involvement of tPA in neuronal cell death by Tsirka (1997)
  71. 10.1038/377340a0 / Nature / Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator by Tsirka (1995)
  72. 10.1016/S0304-3940(98)00562-X / Neurosci. Lett. / Induction of plasminogen in rat hippocampal pyramidal neurons by kainic acid by Matsuoka (1998)
  73. 10.1161/01.CIR.99.18.2440 / Circulation / Role of plasminogen system components in focal cerebral ischemic infarction: a gene targeting and gene transfer study in mice by Nagai (1999)
  74. 10.1073/pnas.94.18.9779 / Proc. Natl. Acad. Sci U. S .A. / Neuronal death in the central nervous system demonstrates a non-fibrin substrate for plasmin by Tsirka (1997)
  75. 10.1126/science.284.5414.647 / Science / Nonproteolytic neuroprotection by human recombinant tissue plasminogen activator by Kim (1999)
  76. 10.1097/00004647-199811000-00001 / J. Cereb. Blood Flow Metab. / Matrix metalloproteinases in cerebrovascular disease by Mun-Bryce (1998)
  77. {'key': '10.1016/S0166-2236(00)01617-9_BIB77', 'first-page': '1979', 'article-title': 'Plasmin and thrombin regulation of NMDA receptor function', 'volume': '25', 'author': 'Junge', 'year': '1999', 'journal-title': 'Soc. Neurosci. Abstr.'} / Soc. Neurosci. Abstr. / Plasmin and thrombin regulation of NMDA receptor function by Junge (1999)
  78. 10.1016/S0092-8674(00)80483-3 / Cell / Neuronal death in the hippocampus is promoted by plasmin-catalysed degradation of laminin by Chen (1997)
  79. 10.1016/S0168-0102(98)00105-9 / Neurosci. Res. / Proteolysis of neuronal cell adhesion molecule by the tissue plasminogen activator-plasmin system after kainate injection in the mouse hippocampus by Endo (1999)
  80. 10.1523/JNEUROSCI.17-02-00543.1997 / J. Neurosci. / An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampus by Tsirka (1997)
  81. 10.1523/JNEUROSCI.19-22-09813.1999 / J. Neurosci. / Neuronal death and blood–brain barrier breakdown after excitotoxic injury are independent processes by Chen (1999)
  82. 10.1161/01.ATV.19.11.2801 / Aterioscler. Thromb. Vasc. Biol. / Tissue plasminogen activator (tPA) deficiency exacerbates cerebrovascular fibrin deposition and brain injury in a murine stroke model by Tabrizi (1999)
  83. 10.1016/S0140-6736(97)03022-5 / Lancet / Systematic review of evidence on thrombolytic therapy for acute stroke by Wardlaw (1997)
  84. 10.1001/jama.274.13.1017 / J. Am. Med. Assoc. / Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke by Hacke (1995)
  85. 10.2165/00003495-199754010-00002 / Drugs / Trends and future developments in the pharmacological treatment of acute stroke by del Zoppo (1997)
Dates
Type When
Created 23 years, 1 month ago (July 25, 2002, 10:14 a.m.)
Deposited 4 years, 3 months ago (May 6, 2021, 7:58 p.m.)
Indexed 2 months, 3 weeks ago (June 10, 2025, 3:03 p.m.)
Issued 25 years ago (Sept. 1, 2000)
Published 25 years ago (Sept. 1, 2000)
Published Print 25 years ago (Sept. 1, 2000)
Funders 0

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@article{Gingrich_2000, title={Serine proteases and brain damage – is there a link?}, volume={23}, ISSN={0166-2236}, url={http://dx.doi.org/10.1016/s0166-2236(00)01617-9}, DOI={10.1016/s0166-2236(00)01617-9}, number={9}, journal={Trends in Neurosciences}, publisher={Elsevier BV}, author={Gingrich, Melissa B. and Traynelis, Stephen F.}, year={2000}, month=sep, pages={399–407} }