Amyloid-β: a chameleon walking in two worlds: a review of the trophic and toxic properties of amyloid-β
10.1016/s0165-0173(03)00174-7
Crossref journal-article
Elsevier BV
Brain Research Reviews (78)
Bibliography

Atwood, C. S., Obrenovich, M. E., Liu, T., Chan, H., Perry, G., Smith, M. A., & Martins, R. N. (2003). Amyloid-β: a chameleon walking in two worlds: a review of the trophic and toxic properties of amyloid-β. Brain Research Reviews, 43(1), 1–16.

Authors 7
  1. Craig S. Atwood (first)
  2. Mark E. Obrenovich (additional)
  3. Tianbing Liu (additional)
  4. Hsien Chan (additional)
  5. George Perry (additional)
  6. Mark A. Smith (additional)
  7. Ralph N. Martins (additional)
References 191 Referenced 223
  1. 10.1016/S0006-291X(84)80190-4 / Biochem. Biophys. Res. Commun. / Alzheimer’s disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein by Glenner (1984)
  2. 10.1073/pnas.82.12.4245 / Proc. Natl. Acad. Sci. USA / Amyloid plaque core protein in Alzheimer disease and Down syndrome by Masters (1985)
  3. 10.1016/0006-291X(84)91209-9 / Biochem. Biophys. Res. Commun. / Alzheimer’s disease and Down’s syndrome: sharing of a unique cerebrovascular amyloid fibril protein by Glenner (1984)
  4. 10.1016/0140-6736(91)92724-G / Lancet / BetaA4 amyloid protein deposition in brain after head trauma by Roberts (1991)
  5. 10.1212/WNL.38.11.1688 / Neurology / A4 amyloid protein deposition and the diagnosis of Alzheimer’s disease: prevalence in aged brains determined by immunocytochemistry compared with conventional neuropathologic techniques by Davies (1988)
  6. 10.1016/S0021-9258(19)85462-5 / J. Biol. Chem. / Processing of the beta-amyloid precursor. Multiple proteases generate and degrade potentially amyloidogenic fragments by Siman (1993)
  7. 10.1126/science.3810169 / Science / Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer’s disease by Goldgaber (1987)
  8. 10.1038/325733a0 / Nature / The precursor of Alzheimer’s disease amyloid A4 protein resembles a cell-surface receptor by Kang (1987)
  9. 10.1126/science.2949367 / Science / Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus by Tanzi (1987)
  10. 10.1038/349704a0 / Nature / Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer’s disease by Goate (1991)
  11. 10.1006/mcne.1999.0811 / Mol. Cell. Neurosci. / Identification of a novel aspartic protease (Asp 2) as beta-secretase by Hussain (1999)
  12. 10.1038/990114 / Nature / Purification and cloning of amyloid precursor protein beta-secretase from human brain by Sinha (1999)
  13. 10.1126/science.286.5440.735 / Science / Beta-secretase cleavage of Alzheimer’s amyloid precursor protein by the transmembrane aspartic protease BACE by Vassar (1999)
  14. 10.1038/990107 / Nature / Membrane-anchored aspartyl protease with Alzheimer’s disease beta-secretase activity by Yan (1999)
  15. 10.1038/19077 / Nature / Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity by Wolfe (1999)
  16. 10.1038/35024009 / Nature / Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing by Yu (2000)
  17. 10.1016/S0197-4580(00)00124-X / Neurobiol Aging. / Inflammation and Alzheimer’s disease by Akiyama (2000)
  18. {'key': '10.1016/S0165-0173(03)00174-7_BIB18', 'series-title': 'Alzheimer’s Disease: Advances in Etiology, Pathogenesis and Therapeutics', 'first-page': '341', 'article-title': 'Neuroinflammatory responses in the Alzheimer’s disease brain promote the oxidative post-translational modification of amyloid deposits', 'author': 'Atwood', 'year': '2001'} / Alzheimer’s Disease: Advances in Etiology, Pathogenesis and Therapeutics / Neuroinflammatory responses in the Alzheimer’s disease brain promote the oxidative post-translational modification of amyloid deposits by Atwood (2001)
  19. 10.1089/15230860050192198 / Antioxid. Redox Signal. / Metabolic, metallic, and mitotic sources of oxidative stress in Alzheimer disease by Smith (2000)
  20. 10.1093/jnen/59.11.1011 / J. Neuropathol. Exp. Neurol. / Neuronal oxidative stress precedes amyloid-β deposition in Down syndrome by Nunomura (2000)
  21. 10.1093/jnen/60.8.759 / J. Neuropathol. Exp. Neurol. / Oxidative damage is the earliest event in Alzheimer disease by Nunomura (2001)
  22. 10.1046/j.1471-4159.2000.0740231.x / J. Neurochem. / Mercury induces cell cytotoxicity and oxidative stress and increases beta-amyloid secretion and tau phosphorylation in SHSY5Y neuroblastoma cells by Olivieri (2000)
  23. 10.1073/pnas.94.18.9866 / Proc. Natl. Acad. Sci. USA / Iron accumulation in Alzheimer disease is a source of redox-generated free radicals by Smith (1997)
  24. 10.1111/j.1749-6632.1994.tb21836.x / Ann. N. Y. Acad. Sci. / Advanced Maillard reaction end products, free radicals, and protein oxidation in Alzheimer’s disease by Smith (1994)
  25. {'key': '10.1016/S0165-0173(03)00174-7_BIB25', 'first-page': '309', 'article-title': 'The role of free radicals and metal ions in the pathogenesis of Alzheimer’s disease. Interrelations between free radicals and metal ions in life processes', 'volume': 'Vol. 36', 'author': 'Atwood', 'year': '1999'} / The role of free radicals and metal ions in the pathogenesis of Alzheimer’s disease. Interrelations between free radicals and metal ions in life processes by Atwood (1999)
  26. {'issue': '4', 'key': '10.1016/S0165-0173(03)00174-7_BIB26', 'first-page': '231', 'article-title': 'Metals and trace elements in plasma and cerebrospinal fluid in normal aging and Alzheimer’s disease', 'volume': '3', 'author': 'Basun', 'year': '1991', 'journal-title': 'J. Neural Transm. Park. Dis. Dement. Sect.'} / J. Neural Transm. Park. Dis. Dement. Sect. / Metals and trace elements in plasma and cerebrospinal fluid in normal aging and Alzheimer’s disease by Basun (1991)
  27. 10.1016/S0006-8993(96)00782-2 / Brain Res. / Increased regional brain concentrations of ceruloplasmin in neurodegenerative disorders by Loeffler (1996)
  28. 10.1016/S0891-5849(99)00016-7 / Free Radic. Biol. Med. / Is increased redox-active iron in Alzheimer disease a failure of the copper-binding protein ceruloplasmin? by Castellani (1999)
  29. {'key': '10.1016/S0165-0173(03)00174-7_BIB29', 'first-page': '191', 'article-title': 'Most amyloid plaques contain ferritin-rich cells', 'volume': '1', 'author': 'Robinson', 'year': '1995', 'journal-title': 'Alzheimer’s Res.'} / Alzheimer’s Res. / Most amyloid plaques contain ferritin-rich cells by Robinson (1995)
  30. 10.1089/neu.1997.14.23 / J. Neurotrauma / Mitochondrial dysfunction and calcium perturbation induced by traumatic brain injury by Xiong (1997)
  31. 10.1016/0304-3940(91)90019-P / Neurosci. Lett. / Induction of amyloid precursor protein mRNA after heat shock in cultured human lymphoblastoid cells by Abe (1991)
  32. 10.1006/exnr.1995.1062 / Exp. Neurol. / Increased amyloid protein precursor and apolipoprotein E immunoreactivity in the selectively vulnerable hippocampus following transient forebrain ischemia in gerbils by Hall (1995)
  33. 10.1007/BF00294806 / Acta Neuropathol. (Berl). / Ischemic stress induces deposition of amyloid beta immunoreactivity in human brain by Jendroska (1995)
  34. 10.1089/neu.1998.15.993 / J. Neurotrauma / Experimental brain injury induces expression of amyloid precursor protein, which may be related to neuronal loss in the hippocampus by Murakami (1998)
  35. 10.1016/S0006-8993(97)00827-5 / Brain Res. / Hypoglycemia enhances the expression of mRNA encoding beta-amyloid precursor protein in rat primary cortical astroglial cells by Shi (1997)
  36. 10.1016/S0006-8993(98)00888-9 / Brain Res. / Estrogen attenuates over-expression of beta-amyloid precursor protein messenger RNA in an animal model of focal ischemia by Shi (1998)
  37. 10.1016/S0197-4580(00)00119-6 / Neurobiol. Aging / Vascular abnormalities: the insidious pathogenesis of Alzheimer’s disease by Shi (2000)
  38. 10.1097/00004647-199611000-00016 / J. Cereb. Blood Flow Metab. / Cytotoxic fragment of amyloid precursor protein accumulates in hippocampus after global forebrain ischemia by Yokota (1996)
  39. 10.1016/S0021-9258(17)36875-8 / J. Biol. Chem. / Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative by Gabuzda (1994)
  40. 10.1016/S0736-5748(98)00082-3 / Int. J. Dev. Neurosci. / Effects of amyloid precursor protein derivatives and oxidative stress on basal forebrain cholinergic systems in Alzheimer’s disease by Mattson (1998)
  41. 10.1074/jbc.271.17.10169 / J. Biol. Chem. / Oxidative stress increases production of β-amyloid precursor protein and β-amyloid (Aβ) in mammalian lenses, and Aβ has toxic effects on lens epithelial cells by Frederiske (1996)
  42. 10.1021/bi000169p / Biochemistry / Oxidative stress induces intracellular accumulation of amyloid beta-protein (Abeta) in human neuroblastoma cells by Misonou (2000)
  43. 10.1034/j.1600-079X.2001.310406.x / J. Pineal Res. / Melatonin protects SHSY5Y neuroblastoma cells from cobalt-induced oxidative stress, neurotoxicity and increased beta-amyloid secretion by Olivieri (2001)
  44. 10.1006/bbrc.1997.6698 / Biochem. Biophys. Res. Commun. / Processing of Alzheimer’s amyloid precursor protein during H2O2-induced apoptosis in human neuronal cells by Zhang (1997)
  45. 10.1006/bbrc.2000.2164 / Biochem. Biophys. Res. Commun. / Oxidative stress induces increase in intracellular amyloid beta-protein production and selective activation of betaI and betaII PKCs in NT2 cells by Paola (2000)
  46. 10.1038/nm0795-693 / Nat. Med. / Non-enzymatically glycated tau in Alzheimer’s disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid beta-peptide by Yan (1995)
  47. {'key': '10.1016/S0165-0173(03)00174-7_BIB47', 'first-page': '295', 'article-title': 'Antioxidants mimic the ability of chorionic gonadotropin to suppress apoptosis in the rabbit corpus luteum in vitro: a novel role for superoxide dismutase in regulating bax expression', 'volume': '2', 'author': 'Dharmarajan', 'year': '1999', 'journal-title': 'Endocrinol. J.'} / Endocrinol. J. / Antioxidants mimic the ability of chorionic gonadotropin to suppress apoptosis in the rabbit corpus luteum in vitro: a novel role for superoxide dismutase in regulating bax expression by Dharmarajan (1999)
  48. 10.1530/jrf.0.0950915 / J. Reprod. Fertil. / Superoxide dismutase activity, lipid peroxide production and corpus luteum steroidogenesis during natural luteolysis and regression induced by oestradiol deprivation of the ovary in pseudopregnant rabbits by Hesla (1992)
  49. 10.1523/JNEUROSCI.15-12-07837.1995 / J. Neurosci. / Related articles increased production of 4 kDa amyloid beta peptide in serum deprived human primary neuron cultures: possible involvement of apoptosis by LeBlanc (1995)
  50. 10.1212/WNL.54.12.2212 / Neurology / Ovariectomy and 17beta-estradiol modulate the levels of Alzheimer’s amyloid beta peptides in brain by Petanceska (2000)
  51. 10.1038/nm0498-447 / Nat. Med. / Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides by Xu (1998)
  52. 10.1016/0896-6273(92)90228-6 / Neuron / The amyloid protein precursor of Alzheimer’s disease is a mediator of the effects of nerve growth factor on neurite outgrowth by Milward (1992)
  53. 10.1038/414643a / Nature / Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP by Kamal (2001)
  54. 10.1074/jbc.C000165200 / J. Biol. Chem. / Evidence that the β-amyloid plaques of Alzheimer’s disease represent the redox-silencing and entombment of Aβ by zinc by Cuajungco (2000)
  55. 10.1111/j.1749-6632.1999.tb07855.x / Ann. N. Y. Acad. Sci. / Neuronal RNA oxidation in Alzheimer’s disease and Down’s syndrome by Nunomura (1999)
  56. 10.1111/j.1749-6632.2000.tb05557.x / Ann. N. Y. Acad. Sci. / Arson: tracking the culprit in Alzheimer’s disease by Smith (2000)
  57. 10.1016/S0002-9440(10)65184-X / Am. J. Pathol. / Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer’s disease by Lue (1999)
  58. 10.1073/pnas.91.23.10771 / Proc. Natl. Acad. Sci. USA / Oxidative damage and mitochondrial decay in aging by Shigenaga (1994)
  59. 10.1074/jbc.273.21.12817 / J. Biol. Chem. / Dramatic aggregation of Alzheimer Aβ by Cu(II) is induced by conditions representing physiological acidosis by Atwood (1998)
  60. 10.1080/10715760100301521 / Free Radic. Res. / Resistance of human cerebrospinal fluid to in vitro oxidation is directly related to its amyloid-beta content by Kontush (2001)
  61. 10.1016/0304-3940(93)90398-5 / Neurosci. Lett. / Beta-amyloid precursor protein (beta APP) as a marker for axonal injury after head injury by Gentleman (1993)
  62. 10.1016/S0079-6123(08)63270-7 / Prog. Brain Res. / Molecular pathology of head trauma: altered beta APP metabolism and the aetiology of Alzheimer’s disease by Gentleman (1993)
  63. 10.1046/j.1471-4159.1998.71062505.x / J. Neurochem. / Traumatic brain injury increases beta-amyloid peptide 1–42 in cerebrospinal fluid by Raby (1998)
  64. 10.1097/00001756-199704140-00039 / Neuroreport / A beta 42 is the predominant form of amyloid beta-protein in the brains of short-term survivors of head injury by Gentleman (1997)
  65. 10.1002/jnr.10388 / J. Neurosci. Res. / A vascular sealant that protects against hemorrhage? by Atwood (2002)
  66. 10.1126/science.299.5609.1014a / Science / Cerebral hemorrhage and amyloid-beta by Atwood (2003)
  67. 10.1046/j.1471-4159.2000.0751219.x / J. Neurochem. / Characterization of copper interactions with Alzheimer amyloid beta peptides: identification of an attomolar-affinity copper binding site on amyloid beta1–42 by Atwood (2000)
  68. 10.1021/bi0002479 / Biochemistry / Metal binding modes of Alzheimer’s amyloid beta-peptide in insoluble aggregates and soluble complexes by Miura (2000)
  69. 10.1074/jbc.M100175200 / J. Biol. Chem. / Alzheimer’s disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits by Curtain (2001)
  70. 10.1016/S0022-510X(98)00092-6 / J. Neurol. Sci. / Copper, iron and zinc in Alzheimer’s disease senile plaques by Lovell (1998)
  71. 10.1126/science.274.5284.99 / Science / Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice by Hsiao (1996)
  72. 10.1021/bi0272151 / Biochemistry / Metal binding and oxidation of amyloid-β within isolated senile plaque cores: raman microscopic evidence by Dong (2003)
  73. 10.1016/S0021-9258(17)32694-7 / J. Biol. Chem. / Modulation of A beta adhesiveness and secretase site cleavage by zinc by Bush (1994)
  74. 10.1126/science.8073293 / Science / Rapid induction of Alzheimer A beta amyloid formation by zinc by Bush (1994)
  75. 10.1074/jbc.272.42.26464 / J. Biol. Chem. / Zinc-induced Alzheimer’s Abeta1–40 aggregation is mediated by conformational factors by Huang (1997)
  76. 10.1074/jbc.M010706200 / J. Biol. Chem. / New insights on how metals disrupt amyloid beta-aggregation and their effects on amyloid-beta cytotoxicity by Yoshiike (2001)
  77. 10.1016/0169-328X(91)90088-F / Brain Res. Mol. Brain Res. / Conservation of the sequence of the Alzheimer’s disease amyloid peptide in dog, polar bear and five other mammals by cross-species polymerase chain reaction analysis by Johnstone (1991)
  78. 10.1021/bi990205o / Biochemistry / Histidine-13 is a crucial residue in the zinc ion-induced aggregation of the A beta peptide of Alzheimer’s disease by Liu (1999)
  79. 10.1073/pnas.90.5.2092 / Proc. Natl. Acad. Sci. USA / Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells by Busciglio (1993)
  80. 10.1074/jbc.274.33.23223 / J. Biol. Chem. / Aqueous dissolution of Alzheimer’s disease Aβ amyloid deposits by biometal depletion by Cherny (1999)
  81. 10.1210/endo-115-3-936 / Endocrinology / Evidence that copper–amino acid complexes are potent stimulators of the release of luteinizing hormone-releasing hormone from isolated hypothalamic granules by Barnea (1984)
  82. 10.1038/308734a0 / Nature / Release of endogenous Zn2+ from brain tissue during activity by Assaf (1984)
  83. 10.1038/308736a0 / Nature / Stimulation-induced uptake and release of zinc in hippocampal slices by Howell (1984)
  84. 10.1074/jbc.274.14.9392 / J. Biol. Chem. / Amyloid beta peptides do not form peptide-derived free radicals spontaneously, but can enhance metal-catalyzed oxidation of hydroxylamines to nitroxides by Dikalov (1999)
  85. 10.1021/bi990438f / Biochemisty / The Aβ peptide of Alzheimer’s disease directly produces hydrogen peroxide through metal ion reduction by Huang (1999)
  86. 10.1074/jbc.274.52.37111 / J. Biol. Chem. / Alzheimer Aβ interaction with Cu(II) induces neurotoxicity, radicalization, metal reduction and hydrogen peroxide formation by Huang (1999)
  87. 10.1016/S1568-1637(02)00002-8 / Ageing Res. Rev. / Amyloid peptide enhances nail rusting: novel insight into mechanisms of aging and Alzheimer’s disease by Mattson (2002)
  88. 10.1073/pnas.94.10.5349 / Proc. Natl. Acad. Sci. USA / Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C by Walter (1997)
  89. 10.1006/jsbi.2000.4274 / J. Struct. Biol. / Review: Alzheimer’s amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity by Varadarajan (2000)
  90. {'key': '10.1016/S0165-0173(03)00174-7_BIB90', 'first-page': '125', 'article-title': 'Biological chemistry of copper–zinc superoxide dismutase and its link to amyotrophic lateral sclerosis', 'volume': '36', 'author': 'Lyons', 'year': '1999', 'journal-title': 'Metal Ions Biol. Systems'} / Metal Ions Biol. Systems / Biological chemistry of copper–zinc superoxide dismutase and its link to amyotrophic lateral sclerosis by Lyons (1999)
  91. {'key': '10.1016/S0165-0173(03)00174-7_BIB91', 'first-page': '14', 'article-title': 'Alzheimer Aβ functions as a superoxide antioxidant in vitro and in vivo', 'volume': '25', 'author': 'Bush', 'year': '1999', 'journal-title': 'Soc. Neurosci. Abstr.'} / Soc. Neurosci. Abstr. / Alzheimer Aβ functions as a superoxide antioxidant in vitro and in vivo by Bush (1999)
  92. {'key': '10.1016/S0165-0173(03)00174-7_BIB92', 'first-page': '1', 'article-title': 'Anti-apoptotic action of Alzheimer Aβ', 'volume': '2', 'author': 'Chan', 'year': '1999', 'journal-title': 'Alzheimer’s Reports'} / Alzheimer’s Reports / Anti-apoptotic action of Alzheimer Aβ by Chan (1999)
  93. 10.1074/jbc.271.12.6839 / J. Biol. Chem. / Inhibition of amyloid beta protein aggregation and neurotoxicity by rifampicin. Its possible function as a hydroxyl radical scavenger by Tomiyama (1996)
  94. 10.1006/abbi.1994.1297 / Arch. Biochem. Biophys. / Antioxidant potential of anaerobic human plasma: role of serum albumin and thiols as scavengers of carbon radicals by Soriani (1994)
  95. 10.1016/S0005-2760(96)00182-8 / Biochim. Biophys. Acta / Physiological thiol compounds exert pro- and anti-oxidant effects, respectively, on iron- and copper-dependent oxidation of human low-density lipoprotein by Lynch (1997)
  96. 10.1016/0006-291X(92)90837-B / Biochem. Biophys. Res. Commun. / Vitamin E protects nerve cells from amyloid beta protein toxicity by Behl (1992)
  97. 10.1073/pnas.96.16.9409 / Proc. Natl. Acad. Sci. USA / Inhibition of NF-kappaB potentiates amyloid beta-mediated neuronal apoptosis by Kaltschmidt (1999)
  98. 10.1073/pnas.90.10.4748 / Proc. Natl. Acad. Sci. USA / Amyloid beta-protein as a substrate interacts with extracellular matrix to promote neurite outgrowth by Koo (1993)
  99. 10.1016/0304-3940(96)13087-1 / Neurosci. Lett. / Physiological levels of beta-amyloid peptide promote PC12 cell proliferation by Luo (1996)
  100. 10.1046/j.1471-4159.2000.741122.x / J. Neurochem. / Substrate-bound beta-amyloid peptides inhibit cell adhesion and neurite outgrowth in primary neuronal cultures by Postuma (2000)
  101. 10.1016/0006-8993(94)91313-7 / Brain Res. / Effect of substance P and protein kinase inhibitors on beta-amyloid peptide-induced proliferation of cultured brain cells by Singh (1994)
  102. 10.1016/0006-8993(92)91274-I / Brain Res. / Amyloid precursor protein accumulates in regions of neurodegeneration following focal cerebral ischemia in the rat by Stephenson (1992)
  103. 10.1016/0024-3205(95)00235-X / Life Sci. / Trophic effects of substance P and beta-amyloid peptide on dibutyryl cyclic AMP-differentiated human leukemic (HL-60) cells by Takenouchi (1995)
  104. 10.1126/science.2928783 / Science / Amyloid beta protein enhances the survival of hippocampal neurons in vitro by Whitson (1989)
  105. 10.1016/0304-3940(90)90867-9 / Neurosci. Lett. / Beta-amyloid protein promotes neuritic branching in hippocampal cultures by Whitson (1990)
  106. 10.1126/science.2218531 / Science / Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides by Yankner (1990)
  107. 10.1016/S0891-5849(00)00458-5 / Free Radic. Biol. Med. / Amyloid-beta is an antioxidant for lipoproteins in cerebrospinal fluid and plasma by Kontush (2001)
  108. 10.1523/JNEUROSCI.22-12-04833.2002 / J. Neurosci. / A novel function of monomeric amyloid beta-protein serving as an antioxidant molecule against metal-induced oxidative damage by Zou (2002)
  109. 10.3233/JAD-2000-2201 / J. Alzheimer’s Dis. / Factors affecting pro- and anti-oxidant properties of fragments of the β-protein precursor (βPP): implication for Alzheimer’s disease by Andorn (2000)
  110. 10.1016/S0925-4439(00)00057-0 / Biochim. Biophys. Acta / Differential alterations in antioxidant capacity in cells from Alzheimer patients by Gibson (2000)
  111. 10.1523/JNEUROSCI.18-23-09790.1998 / J. Neurosci. / Overexpression in neurons of human presenilin-1 or a presenilin-1 familial Alzheimer disease mutant does not enhance apoptosis by Bursztajn (1998)
  112. 10.1016/S0304-3940(00)01449-X / Neurosci. Lett. / Reduced antioxidant enzyme activity in brains of mice transgenic for human presenilin-1 with single or multiple mutations by Leutner (2000)
  113. 10.1038/nm0798-827 / Nat. Med. / Aging renders the brain vulnerable to amyloid β-protein neurotoxicity by Geula (1998)
  114. 10.3109/13506129809007283 / Amyloid / The neurotoxicity of amyloid β protein in aged primates by McKee (1998)
  115. 10.1007/s00702-002-0796-2 / J. Neural Transm. / Deposits of fibrillar Aβ do not cause neuronal loss or ferritin expression in adult rat brain by Bishop (2003)
  116. 10.1016/S0197-4580(00)83347-3 / Neurobiol. Aging / β-Amyloid helps to protect neurons from oxidative stress by Bishop (2000)
  117. 10.1038/4789 / Nat. Med. / Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice by Guo (1999)
  118. 10.1046/j.1471-4159.1999.0721019.x / J. Neurochem. / Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation by Guo (1999)
  119. 10.1016/0891-5849(95)02207-4 / Free Radic. Biol. Med. / The effect of ascorbate and ubiquinone supplementation on plasma and CSF total antioxidant capacity by Lonnrot (1996)
  120. {'key': '10.1016/S0165-0173(03)00174-7_BIB120', 'first-page': 'S284', 'article-title': 'Neuronal cell cultures protect low density lipoprotein from oxidation', 'volume': '19', 'author': 'Berndt', 'year': '1998', 'journal-title': 'Neurobiol. Aging'} / Neurobiol. Aging / Neuronal cell cultures protect low density lipoprotein from oxidation by Berndt (1998)
  121. 10.1016/S0014-5793(00)01123-6 / FEBS Lett. / Presence of CuZn superoxide dismutase in human serum lipoproteins by Mondola (2000)
  122. 10.1016/S0968-0004(97)01047-5 / Trends Biochem. Sci. / Peptides in membranes: tipping the balance of membrane stability by Brasseur (1997)
  123. 10.1006/bbrc.1994.2788 / Biochem. Biophys. Res. Commun. / The soluble form of Alzheimer’s amyloid beta protein is complexed to high density lipoprotein 3 and very high density lipoprotein in normal human plasma by Koudinov (1994)
  124. 10.1006/bbrc.1996.0940 / Biochem. Biophys. Res. Commun. / Biochemical characterization of Alzheimer’s soluble amyloid beta protein in human cerebrospinal fluid: association with high density lipoproteins by Koudinov (1996)
  125. 10.1073/pnas.95.11.6460 / Proc. Natl. Acad. Sci. USA / Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons by Simons (1998)
  126. 10.1006/exnr.1994.1044 / Exp. Neurol. / Induction of Alzheimer-like beta-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol by Sparks (1994)
  127. 10.1006/nbdi.2001.0422 / Neurobiol. Dis. / A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer’s disease by Refolo (2001)
  128. 10.1074/jbc.M009598200 / J. Biol. Chem. / Accumulation and aggregation of amyloid beta-protein in late endosomes of Niemann–Pick type C cells by Yamazaki (2001)
  129. 10.1016/0306-4522(94)00610-H / Neuroscience / Differential effects of amyloid peptides β-(1–40) and β-(25–35) injections into the rat nucleus basalis by Giovannelli (1995)
  130. 10.1016/S0306-4522(98)00169-9 / Neuroscience / Long-term changes in the aggregation state and toxic effects of β-amyloid injected into the rat brain by Giovannelli (1998)
  131. {'key': '10.1016/S0165-0173(03)00174-7_BIB131', 'first-page': '307', 'article-title': 'Microglial response to amyloid plaques in APPsw transgenic mice', 'volume': '152', 'author': 'Frautschy', 'year': '1998', 'journal-title': 'Am. J. Pathol.'} / Am. J. Pathol. / Microglial response to amyloid plaques in APPsw transgenic mice by Frautschy (1998)
  132. 10.1016/S0047-6374(99)00086-X / Mech. Ageing Dev. / Aβ and perlecan in rat brain: glial activation, gradual clearance and limited neurotoxicity by Holcomb (2000)
  133. {'key': '10.1016/S0165-0173(03)00174-7_BIB133', 'first-page': '213', 'article-title': 'High levels of microglial iron in the cortices of old primates: implications for the neurotoxicity of β-amyloid', 'volume': '10', 'author': 'Fox', 'year': '1999', 'journal-title': 'Proc. Aust. Neurosci. Soc.'} / Proc. Aust. Neurosci. Soc. / High levels of microglial iron in the cortices of old primates: implications for the neurotoxicity of β-amyloid by Fox (1999)
  134. 10.1016/0197-4580(92)90054-2 / Neurobiol. Aging / Effect of beta amyloid peptides on neurons in hippocampal slice cultures by Malouf (1992)
  135. 10.1016/0922-4106(91)90014-9 / Eur. J. Pharmacol. / Aggregation-related toxicity of synthetic beta-amyloid protein in hippocampal cultures by Pike (1991)
  136. 10.1523/JNEUROSCI.13-04-01676.1993 / J. Neurosci. / Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state by Pike (1993)
  137. {'key': '10.1016/S0165-0173(03)00174-7_BIB137', 'first-page': '373', 'article-title': 'Secondary structure of amyloid beta peptide correlates with neurotoxic activity in vitro', 'volume': '45', 'author': 'Simmons', 'year': '1994', 'journal-title': 'Mol. Pharmacol.'} / Mol. Pharmacol. / Secondary structure of amyloid beta peptide correlates with neurotoxic activity in vitro by Simmons (1994)
  138. 10.1006/bbrc.1994.2816 / Biochem. Biophys. Res. Commun. / Tissue-dependent alternative splicing of mRNA for NACP, the precursor of non-A beta component of Alzheimer’s disease amyloid by Ueda (1994)
  139. 10.1073/pnas.95.11.6448 / Proc. Natl. Acad. Sci. USA / Diffusible, nonfibrillar ligands derived from Abeta1–42 are potent central nervous system neurotoxins by Lambert (1998)
  140. 10.1016/0197-4580(95)02020-9 / Neurobiol. Aging / Deposits of A beta fibrils are not toxic to cortical and hippocampal neurons in vitro by Wujek (1996)
  141. 10.1006/bbrc.1995.2678 / Biochem. Biophys. Res. Commun. / The role of iron in beta amyloid toxicity by Schubert (1995)
  142. 10.1016/S0197-4580(01)00342-6 / Neurobiol. Aging / Amyloid beta as a bioflocculant: implications for the amyloid hypothesis of Alzheimer’s disease by Robinson (2002)
  143. 10.1016/S0891-5849(00)00494-9 / Free Radic. Biol. Med. / Redox-active iron mediates amyloid-β toxicity by Rottkamp (2001)
  144. 10.1016/S0891-5849(01)00510-X / Free Radic. Biol. Med. / New evidence that the Alzheimer β-amyloid peptide does not spontaneously form free radicals: an ESR study using a series of spin-traps by Turnbull (2001)
  145. 10.1006/exnr.1997.6738 / Exp. Neurol. / Astrocytes regulate microglial phagocytosis of senile plaque cores of Alzheimer’s disease by DeWitt (1998)
  146. 10.1097/00005072-199709000-00002 / J. Neuropathol. Exp. Neurol. / APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1 by Irizarry (1997)
  147. 10.1523/JNEUROSCI.17-18-07053.1997 / J. Neurosci. / Aβ deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse by Irizarry (1997)
  148. 10.1073/pnas.092136199 / Proc. Natl. Acad. Sci. USA / Tau is essential to beta-amyloid-induced neurotoxicity by Rapoport (2002)
  149. 10.1385/NMM:1:1:81 / Neuromolecular Med. / The influence of the carboxyl terminus of the Alzheimer Abeta peptide on its confirmation, aggregation, and neurotoxic properties by Soreghan (2002)
  150. 10.1016/0022-2836(92)90106-T / J. Mol. Biol. / Solution conformations and aggregational properties of synthetic amyloid beta-peptides of Alzheimer’s disease. Analysis of circular dichroism spectra by Barrow (1992)
  151. 10.1021/bi00139a028 / Biochemistry / NMR studies of amyloid beta-peptides: proton assignments, secondary structure, and mechanism of an alpha-helix—beta-sheet conversion for a homologous, 28-residue. N-terminal fragment by Zagorski (1992)
  152. 10.1042/bj3110001 / Biochem. J. / The toxicity in vitro of beta-amyloid protein by Iversen (1995)
  153. 10.1126/science.1853202 / Science / Solution structures of beta peptide and its constituent fragments: relation to amyloid deposition by Barrow (1991)
  154. 10.1021/bi982437d / Biochemistry / Differential effects of apolipoprotein E isoforms on metal-induced aggregation of A beta using physiological concentrations by Moir (1999)
  155. 10.1016/S0361-9230(99)00093-3 / Brain Res. Bull. / Methionine residue 35 is important in amyloid beta-peptide-associated free radical oxidative stress by Varadarajan (1999)
  156. 10.1021/ja010452r / J. Am. Chem. Soc. / Different mechanisms of oxidative stress and neurotoxicity for Alzheimer’s A beta(1–42) and A beta(25–35) by Varadarajan (2001)
  157. 10.1016/0024-3205(95)02279-1 / Life Sci. / A beta (25–35) peptide displays H2O2-like reactivity towards aqueous Fe2+, nitroxide spin probes, and synaptosomal membrane proteins by Butterfield (1996)
  158. 10.1016/S0006-8993(98)00461-2 / Brain Res. / Promotion of transition metal-induced reactive oxygen species formation by beta-amyloid by Bondy (1998)
  159. 10.1006/bbrc.1994.1508 / Biochem. Biophys. Res. Commun. / Beta-amyloid peptide free radical fragments initiate synaptosomal lipoperoxidation in a sequence-specific fashion: implications to Alzheimer’s disease by Butterfield (1994)
  160. 10.1080/10715760000300111 / Free Radic. Res. / Time–course of oxidation of lipids in human cerebrospinal fluid in vitro by Arlt (2000)
  161. 10.1046/j.1471-4159.1997.68010255.x / J. Neurochem. / A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide by Mark (1997)
  162. 10.1097/00004647-200106000-00008 / J. Cereb. Blood Flow Metab. / Amyloid beta peptide-induced cerebral endothelial cell death involves mitochondrial dysfunction and caspase activation by Xu (2001)
  163. 10.1073/pnas.91.8.3270 / Proc. Natl. Acad. Sci. USA / A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease by Hensley (1994)
  164. 10.1016/0092-8674(94)90131-7 / Cell / Hydrogen peroxide mediates amyloid beta protein toxicity by Behl (1994)
  165. 10.1046/j.1471-4159.1995.64031216.x / J. Neurochem. / Decreased catalase activity but unchanged superoxide dismutase activity in brains of patients with dementia of Alzheimer type by Gsell (1995)
  166. 10.1046/j.1471-4159.1995.65052146.x / J. Neurochem. / Brain regional correspondence between Alzheimer’s disease histopathology and biomarkers of protein oxidation by Hensley (1995)
  167. 10.1038/380168a0 / Nature / Beta-amyloid-mediated vasoactivity and vascular endothelial damage by Thomas (1996)
  168. 10.1016/0006-8993(95)00148-J / Brain Res. / Different amyloidogenic peptides share a similar mechanism of neurotoxicity involving reactive oxygen species and calcium by Mattson (1995)
  169. 10.1007/BF02755589 / Mol. Neurobiol. / Amyloid beta-peptide and oxidative cellular injury in Alzheimer’s disease by Mark (1996)
  170. 10.1016/S0891-5849(96)00629-6 / Free Radic. Biol. Med. / Oxidative stress hypothesis in Alzheimer’s disease by Markesbery (1997)
  171. 10.1056/NEJM198906013202203 / New Engl. J. Med. / Amyloid A4 protein and its precursor in Down’s syndrome and Alzheimer’s disease by Rumble (1989)
  172. 10.1038/nm0196-93 / Nat. Med. / Presence of soluble amyloid beta-peptide precedes amyloid plaque formation in Down’s syndrome by Teller (1996)
  173. 10.1038/378776a0 / Nature / Apoptosis and increased generation of reactive oxygen species in Down’s syndrome neurons in vitro by Busciglio (1995)
  174. 10.1016/S1367-5931(99)00073-3 / Curr Opin. Chem. Biol. / Metals and neuroscience by Bush (2000)
  175. 10.1021/bi00102a024 / Biochemistry / The balance between Cu,Zn-superoxide dismutase and catalase affects the sensitivity of mouse epidermal cells to oxidative stress by Amstad (1991)
  176. 10.1006/geno.1996.0096 / Genomics / Characterization of the genomic structure of the mouse APLP1 gene by Zhong (1996)
  177. 10.1016/S0021-9258(19)74050-2 / J. Biol. Chem. / Hydroxyl radical production by H2O2 plus Cu,Zn-superoxide dismutase reflects the activity of free copper released from the oxidatively damaged enzyme by Sato (1992)
  178. 10.1126/science.281.5384.1851 / Science / Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1 by Bruijn (1998)
  179. 10.1074/jbc.273.46.30104 / J. Biol. Chem. / Reactions of hydrogen peroxide with familial amyotrophic lateral sclerosis mutant human copper–zinc superoxide dismutases studied by pulse radiolysis by Goto (1998)
  180. 10.1042/bj1390043 / Biochem. J. / Reduction and inactivation of superoxide dismutase by hydrogen peroxide by Bray (1974)
  181. 10.1016/0003-9861(83)90245-X / Arch. Biochem. Biophys. / Hydroperoxide anion, HO-2, is an affinity reagent for the inactivation of yeast Cu. Zn-superoxide dismutase: modification of one histidine per subunit by Blech (1983)
  182. 10.1016/S0021-9258(17)41960-0 / J. Biol. Chem. / Identification of oxidized histidine generated at the active site of Cu,Zn-superoxide dismutase exposed to H2O2 by Uchida (1994)
  183. 10.1074/jbc.272.14.9019 / J. Biol. Chem. / Metal-catalyzed oxidation of histidine in human growth hormone by Zhao (1997)
  184. 10.1016/S0197-4580(00)82237-X / Neurobiol. Aging / Human amyloid-derived Aβ contains tyrosine cross-linked oligomers by Atwood (2000)
  185. 10.1126/science.286.5441.916 / Science / The presenilins in Alzheimer’s disease—proteolysis holds the key by Haass (1999)
  186. 10.1038/22124 / Nature / Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse by Schenk (1999)
  187. 10.1038/78682 / Nat. Med. / Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease by Bard (2000)
  188. 10.1002/1097-0029(20000815)50:4<287::AID-JEMT7>3.0.CO;2-L / Microsc. Res. Tech. / 3rd Link between heart disease, cholesterol, and Alzheimer’s disease: a review by Sparks (2000)
  189. 10.1016/S0896-6273(01)00317-8 / Neuron / Treatment with a copper–zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer’s disease transgenic mice by Cherny (2001)
  190. 10.1016/0197-4580(96)00115-7 / Neurobiol. Aging / Inflammation and Alzheimer’s disease pathogenesis by Rogers (1996)
  191. 10.1021/ja994436u / J. Am. Chem. Soc. / Is oxidative damage by amyloid and prion peptides mediated by hydrogen atom transfer from glycine carbon to methionine sulfur within sheets? by Rauk (2000)
Dates
Type When
Created 22 years ago (July 31, 2003, 6:43 p.m.)
Deposited 4 years, 2 months ago (June 8, 2021, 8:24 p.m.)
Indexed 1 week ago (Aug. 20, 2025, 8:26 a.m.)
Issued 21 years, 11 months ago (Sept. 1, 2003)
Published 21 years, 11 months ago (Sept. 1, 2003)
Published Print 21 years, 11 months ago (Sept. 1, 2003)
Funders 0

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@article{Atwood_2003, title={Amyloid-β: a chameleon walking in two worlds: a review of the trophic and toxic properties of amyloid-β}, volume={43}, ISSN={0165-0173}, url={http://dx.doi.org/10.1016/s0165-0173(03)00174-7}, DOI={10.1016/s0165-0173(03)00174-7}, number={1}, journal={Brain Research Reviews}, publisher={Elsevier BV}, author={Atwood, Craig S. and Obrenovich, Mark E. and Liu, Tianbing and Chan, Hsien and Perry, George and Smith, Mark A. and Martins, Ralph N.}, year={2003}, month=sep, pages={1–16} }