DOI: 10.1016/s0163-7258(96)00140-4. Human P450 metabolism of warfarin

Human P450 metabolism of warfarin

10.1016/s0163-7258(96)00140-4

Crossref journal-article

Elsevier BV

Pharmacology & Therapeutics (78)

Bibliography

Kaminsky, L. S., & Zhang, Z.-Y. (1997). Human P450 metabolism of warfarin. Pharmacology & Therapeutics, 73(1), 67â74.

Authors 2

Laurence S. Kaminsky (first)
Zhi-Yi Zhang (additional)

References 57 Referenced 645

{'key': '10.1016/S0163-7258(96)00140-4_BIB1', 'first-page': '411', 'article-title': 'Selective inhibition of warfarin metabolism by diltiazem in humans', 'volume': '257', 'author': 'Abernethy', 'year': '1991', 'journal-title': 'J. Pharmacol. Exp. Ther.'} / J. Pharmacol. Exp. Ther. / Selective inhibition of warfarin metabolism by diltiazem in humans by Abernethy (1991)
10.1111/j.1365-2125.1983.tb02239.x / Br. J. Clin. Pharmacol. / Phenylbutazone-warfarin interaction in man: further stereochemical and metabolic considerations by Banfield (1985)
10.1111/j.1365-2125.1995.tb04453.x / Br. J. Clin. Pharmacol. / The effect of ciprofloxacin on theophylline pharmacokinetics in healthy subjects by Batty (1995)
10.2165/00003088-199529030-00005 / Clin. Pharmacokinet. / Geographical/interracial differences in polymorphic drug oxidation. Current state ot knowledge of cytochromes P450 (CYP) 2D6 and 2C19 by Bertilsson (1995)
10.1021/bi00503a018 / Biochemistry / Catalytic activities of human liver cytochrome P-450 IIIA4 expressed in Saccharomyces cerevisiae by Brian (1990)
10.1111/j.1365-2125.1995.tb04488.x / Br. J. Clin. Pharmacol. / Interphenotype differences in disposition and effect on gastrin levels of omeprazole-suitability of omeprazole as a probe for CYP2C19 by Chang (1995)
10.1016/S0021-9258(18)48462-1 / J. Biol. Chem. / Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins interred from comparative analyses of amino acid and coding nucleotide sequences by Gotoh (1992)
10.1021/jm00374a027 / J. Med. Chem. / The preferred solution conformation of warfarin at the active site of cytochrome P-450 based on the CD spectra in octanol/water model system by Heimark (1984)
10.1038/clpt.1987.168 / Clin. Pharmacol. Ther. / The mechanism ot the warfarin-rifampin drug interaction in humans by Heimark (1987)
10.1016/0006-2952(89)90635-7 / Biochem. Pharmacol. / The in vitro ketone reduction of warfarin and analogues. Substrate stercoselectivity, product stereoselectivity and species differences by Hermans (1989)
{'key': '10.1016/S0163-7258(96)00140-4_BIB11', 'first-page': '268', 'article-title': 'Stereoselective acetonyl side chain reduction of warfarin and analogs: partial characterization of two cytosolic carbonyl reductases', 'volume': '20', 'author': 'Hermans', 'year': '1992', 'journal-title': 'Drug Metab. Dispos.'} / Drug Metab. Dispos. / Stereoselective acetonyl side chain reduction of warfarin and analogs: partial characterization of two cytosolic carbonyl reductases by Hermans (1992)
10.1111/j.1476-5381.1993.tb13836.x / Br. J. Pharmacol. / Human liver microsomal metabolism of the enantiomers of warfarin and acenocoumarol: P450 isozyme diversity determines the differences in their pharmacokinetics by Hermans (1993)
10.1016/0006-2952(92)90010-G / Biochem. Pharmacol. / Effect of age and gender on the activity ot human hepatic CYP3A by Hunt (1992)
10.1021/ja01234a019 / J. Am. Chem. Soc. / Studies on 4-hydroxycoumarins. V. The condensation of alpha, beta-unsaturated ketones with 4-hydroxycoumarin by Ikawa (1944)
10.1016/0009-9236(95)90193-0 / Clin. Pharmacol. Ther. / Comparison of the interaction potential of a new proton pump inhibitor, E3810, versus omeprazole with diazepam in extensive and poor metabolizers of S-mephenytoin 4′-hydroxylation by Ishizaki (1995)
10.1093/clinids/22.2.251 / Clin. Infect. Dis. / Effect of ciprofloxacin on the pharmacokinetics and pharmacodynamics of warfarin by Israel (1996)
{'key': '10.1016/S0163-7258(96)00140-4_BIB17', 'first-page': '209', 'article-title': 'Phase II metabolism of warfarin in primary culture of adult rat hepatocytes', 'volume': '41', 'author': 'Jansing', 'year': '1992', 'journal-title': 'Mol. Pharmacol.'} / Mol. Pharmacol. / Phase II metabolism of warfarin in primary culture of adult rat hepatocytes by Jansing (1992)
{'key': '10.1016/S0163-7258(96)00140-4_BIB18', 'first-page': '260', 'article-title': 'Putative active site template model for cytochrome P4502C9 (tobutamide hydroxyalse)', 'volume': '24', 'author': 'Jones', 'year': '1996', 'journal-title': 'Drug Metab. Dispos.'} / Drug Metab. Dispos. / Putative active site template model for cytochrome P4502C9 (tobutamide hydroxyalse) by Jones (1996)
10.3109/03602538909103554 / Drug Metab. Rev. / Warfarin as a probe of cytochromes P-450 function by Kaminsky (1989)
{'key': '10.1016/S0163-7258(96)00140-4_BIB20', 'first-page': '470', 'article-title': 'Human hepatic cytochrome P-450 composition as probed by in vitro microsomal metabolism of warfarin', 'volume': '12', 'author': 'Kaminsky', 'year': '1984', 'journal-title': 'Drug Metab. Dispos.'} / Drug Metab. Dispos. / Human hepatic cytochrome P-450 composition as probed by in vitro microsomal metabolism of warfarin by Kaminsky (1984)
{'key': '10.1016/S0163-7258(96)00140-4_BIB21', 'first-page': '234', 'article-title': 'Correlation of human cytochrome P4502C substrate specificities with primary structure: warfarin as a probe', 'volume': '43', 'author': 'Kaminsky', 'year': '1993', 'journal-title': 'Mol. Pharmacol.'} / Mol. Pharmacol. / Correlation of human cytochrome P4502C substrate specificities with primary structure: warfarin as a probe by Kaminsky (1993)
{'key': '10.1016/S0163-7258(96)00140-4_BIB22', 'first-page': '183', 'article-title': 'Cytochrome P450: probes of active site residue', 'author': 'Kaminsky', 'year': '1993'} / Cytochrome P450: probes of active site residue by Kaminsky (1993)
10.1038/clpt.1987.152 / Clin. Pharmacol. Ther. / Interaction between warfarin and propafenone in healthy volunteer subjects by Kates (1987)
10.1002/chir.530030106 / Chirality / Metabolic enantiomeric interactions: the inhibition of human (S)-warfarin-7-hydroxylase by (R)-warfarin by Kunze (1991)
10.1172/JCI107711 / J. Clin. Invest. / Warfarin, stereochemical aspects of metabolism and the interaction with phenylbutazone by Lewis (1974)
{'key': '10.1016/S0163-7258(96)00140-4_BIB26', 'first-page': '673', 'article-title': 'Rifampicin induction of lidocaine metabolism in cultured human hepatocytes', 'volume': '274', 'author': 'Li', 'year': '1995', 'journal-title': 'J. Pharmacol. Exp. Ther.'} / J. Pharmacol. Exp. Ther. / Rifampicin induction of lidocaine metabolism in cultured human hepatocytes by Li (1995)
10.1021/bi00033a007 / Biochemistry / The substrate binding site of human liver cytochrome P4502C9: an approach using designed tienilic acid derivatives and molecular modeling by Mancy (1995)
10.1016/0006-2952(75)90381-0 / Biochem. Pharmacol. / Studies on a ketone reductase in human and rat liver and kidney soluble fraction using warfarin as a substrate by Moreland (1975)
{'key': '10.1016/S0163-7258(96)00140-4_BIB29', 'first-page': '259', 'article-title': 'Role of hydrogen-bonding in substrate structure-activity relationships tor CYP2C9', 'volume': 'Vol. 8', 'author': 'Morsman', 'year': '1995'} / Role of hydrogen-bonding in substrate structure-activity relationships tor CYP2C9 by Morsman (1995)
10.1097/00008571-199602000-00002 / Pharmacogenetics / P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature by Nelson (1996)
10.1016/0003-9861(92)90160-X / Arch. Biochem. Biophys. / Azidowarfarin photoaffinity probes of purified rat liver cytochrome P4501A1 by Obach (1992)
10.7326/0003-4819-83-4-506 / Ann. Intern. Med. / Interaction of chronic daily warfarin therapy and rifampin by O'Reilly (1975)
10.1056/NEJM197608122950702 / N. Engl. J. Med. / The stereoselective interaction of warfarin and metronidazole in man by O'Reilly (1976)
{'key': '10.1016/S0163-7258(96)00140-4_BIB34', 'first-page': '691', 'article-title': 'Comparative interaction of sulfinpyrazone and phenylbutazone with racemic warfarin: alteration in vivo of free fraction of plasma warfarin', 'volume': '219', 'author': "O'Reilly", 'year': '1981', 'journal-title': 'J. Pharmacol. Exp. Ther.'} / J. Pharmacol. Exp. Ther. / Comparative interaction of sulfinpyrazone and phenylbutazone with racemic warfarin: alteration in vivo of free fraction of plasma warfarin by O'Reilly (1981)
10.1038/clpt.1987.149 / Clin. Pharmacol. Ther. / Interaction of amiodarone with racemic warfarin and its separated enantiomorphs in humans by O'Reilly (1987)
10.1111/j.1365-2125.1994.tb04399.x / Br. J. Clin. Pharmacol. / Inhibition of caffeine metabolism by ciprofloxacin in children with cystic fibrosis as measured by the caffeine breath test by Parker (1994)
{'key': '10.1016/S0163-7258(96)00140-4_BIB37', 'series-title': "Casarett and Doull's Toxicology: The Basic Science of Poisons", 'first-page': '113', 'article-title': 'Biotransformation of xenobtotics', 'author': 'Parkinson', 'year': '1996'} / Casarett and Doull's Toxicology: The Basic Science of Poisons / Biotransformation of xenobtotics by Parkinson (1996)
{'key': '10.1016/S0163-7258(96)00140-4_BIB38', 'first-page': '265', 'article-title': 'Characteristics of warfarin hydroxylation catalyzed by human liver microsomes', 'volume': '17', 'author': 'Rettie', 'year': '1989', 'journal-title': 'Drug Metab. Dispos.'} / Drug Metab. Dispos. / Characteristics of warfarin hydroxylation catalyzed by human liver microsomes by Rettie (1989)
10.1021/tx00025a009 / Chem. Res. Toxicol. / Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions by Rettie (1992)
10.1097/00008571-199402000-00005 / Pharmacogenetics / Impaired (S)-warfarin metabolism catalysed by the R144C allelic variant of CYP2C9 by Rettie (1994)
10.1093/carcin/16.7.1549 / Carcinogenesis / Cytochromes P450 in cynomolgus monkeys mutagenically activate 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) but not 2-amino-3,8-dimethyl-imidazo[4,5-f]quinoxaline (MeIQx) by Sadrieh (1995)
10.1177/000331975300400410 / Angiology / Warfarin sodium derivative (coumadin sodium): intravenous hypoprothrombinemia-inducing agent by Shapiro (1953)
{'key': '10.1016/S0163-7258(96)00140-4_BIB43', 'first-page': '414', 'article-title': 'Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians', 'volume': '270', 'author': 'Shimada', 'year': '1994', 'journal-title': 'J. Pharmacol. Exp. Ther.'} / J. Pharmacol. Exp. Ther. / Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians by Shimada (1994)
10.1002/j.1552-4604.1996.tb04182.x / J. Clin. Pharmacol. / Enbancement of anticoagulant action by wartarin-benzbromarone interaction by Shimodaira (1996)
10.1111/j.1365-2125.1994.tb04316.x / Br. J. Clin. Pharmacol. / The effect of enzyme inhibition on the metabolism and activation of tacrine by human liver microsomes by Spaldin (1994)
10.1097/00008571-199608000-00007 / Pharmacogenetics / The role of the CYP2C9-Ile359 allelic variant in the tolbutamide polymorphism by Sullivan (1996)
10.1097/00007691-198903000-00010 / Ther. Drug Monit. / Stereoselective interaction of omeprazole with warfarin in healthy men by Sutfin (1989)
10.1038/clpt.1986.3 / Clin. Pharmacol. Ther. / The warfarin-sulfin-pyrazone interaction: stereochemical considerations by Toon (1986)
10.1038/clpt.1987.104 / Clin. Pharmacol. Ther. / Enoxacin-warfarin interaction: pharmacokinetic and stereochemical aspects by Toon (1987)
10.3109/03602538909103555 / Drug Metab. Rev. / Stereochemistry of cytochrome P-450 reactions by Trager (1989)
10.1021/jm00300a041 / J. Med. Chem. / Mass spectral analysis in the identification of human metabolites of warfarin by Trager (1970)
10.1111/j.1365-2125.1992.tb05656.x / Br. J. Clin. Pharmacol. / A study of the interaction of omeprazole and warfarin in anticoagulated patients by Unge (1992)
10.1021/bi00292a019 / Biochemistry / Purification and characterization of six cytochrome P-450 isozymes from human liver microsomes by Wang (1983)
10.7326/0003-4819-121-9-199411010-00009 / Ann. Intern. Med. / Interactions of warfarin with drugs and food by Wells (1994)
{'key': '10.1016/S0163-7258(96)00140-4_BIB55', 'first-page': '610', 'article-title': 'The formation of (R)-8-hydroxywarfarin in human liver microsomes: a new metabolic marker tor the (S)-mephenytoin hydroxylase, P4502C19', 'volume': '24', 'author': 'Wienkers', 'year': '1996', 'journal-title': 'Drug Metab. Dispos.'} / Drug Metab. Dispos. / The formation of (R)-8-hydroxywarfarin in human liver microsomes: a new metabolic marker tor the (S)-mephenytoin hydroxylase, P4502C19 by Wienkers (1996)
{'key': '10.1016/S0163-7258(96)00140-4_BIB56', 'first-page': '1339', 'article-title': 'Human cytochromes P4501A1 and P4501A2: R-warfarin metabolism as a probe', 'volume': '23', 'author': 'Zbang', 'year': '1995', 'journal-title': 'Drug Metab. Dispos.'} / Drug Metab. Dispos. / Human cytochromes P4501A1 and P4501A2: R-warfarin metabolism as a probe by Zbang (1995)
{'key': '10.1016/S0163-7258(96)00140-4_BIB57', 'first-page': '3926', 'article-title': 'Characterization of purified human recombinant CYP1A1-Ile462 and Val462: assessment of a role for the rare allele in carcinogenesis', 'volume': '56', 'author': 'Zhang', 'year': '1996', 'journal-title': 'Cancer Res.'} / Cancer Res. / Characterization of purified human recombinant CYP1A1-Ile462 and Val462: assessment of a role for the rare allele in carcinogenesis by Zhang (1996)

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 4:05 p.m.)
Deposited	4 years, 3 months ago (May 13, 2021, 1:53 a.m.)
Indexed	6 days, 18 hours ago (Aug. 30, 2025, 1:12 p.m.)
Issued	28 years, 8 months ago (Jan. 1, 1997)
Published	28 years, 8 months ago (Jan. 1, 1997)
Published Print	28 years, 8 months ago (Jan. 1, 1997)

Funders 0

None

BibTeX

@article{Kaminsky_1997, title={Human P450 metabolism of warfarin}, volume={73}, ISSN={0163-7258}, url={http://dx.doi.org/10.1016/s0163-7258(96)00140-4}, DOI={10.1016/s0163-7258(96)00140-4}, number={1}, journal={Pharmacology & Therapeutics}, publisher={Elsevier BV}, author={Kaminsky, Laurence S. and Zhang, Zhi-Yi}, year={1997}, month=jan, pages={67–74} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        30
      ]
    ],
    "date-time": "2025-08-30T17:12:31Z",
    "timestamp": 1756573951787
  },
  "reference-count": 57,
  "publisher": "Elsevier BV",
  "issue": "1",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1997,
            1,
            1
          ]
        ],
        "date-time": "1997-01-01T00:00:00Z",
        "timestamp": 852076800000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1997,
        1
      ]
    ]
  },
  "DOI": "10.1016/s0163-7258(96)00140-4",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        7,
        25
      ]
    ],
    "date-time": "2002-07-25T20:05:40Z",
    "timestamp": 1027627540000
  },
  "page": "67-74",
  "source": "Crossref",
  "is-referenced-by-count": 645,
  "title": "Human P450 metabolism of warfarin",
  "prefix": "10.1016",
  "volume": "73",
  "author": [
    {
      "given": "Laurence S.",
      "family": "Kaminsky",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Zhi-Yi",
      "family": "Zhang",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB1",
      "first-page": "411",
      "article-title": "Selective inhibition of warfarin metabolism by diltiazem in humans",
      "volume": "257",
      "author": "Abernethy",
      "year": "1991",
      "journal-title": "J. Pharmacol. Exp. Ther."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "669",
      "DOI": "10.1111/j.1365-2125.1983.tb02239.x",
      "article-title": "Phenylbutazone-warfarin interaction in man: further stereochemical and metabolic considerations",
      "volume": "16",
      "author": "Banfield",
      "year": "1985",
      "journal-title": "Br. J. Clin. Pharmacol."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "305",
      "DOI": "10.1111/j.1365-2125.1995.tb04453.x",
      "article-title": "The effect of ciprofloxacin on theophylline pharmacokinetics in healthy subjects",
      "volume": "39",
      "author": "Batty",
      "year": "1995",
      "journal-title": "Br. J. Clin. Pharmacol."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB4",
      "doi-asserted-by": "crossref",
      "first-page": "192",
      "DOI": "10.2165/00003088-199529030-00005",
      "article-title": "Geographical/interracial differences in polymorphic drug oxidation. Current state ot knowledge of cytochromes P450 (CYP) 2D6 and 2C19",
      "volume": "29",
      "author": "Bertilsson",
      "year": "1995",
      "journal-title": "Clin. Pharmacokinet."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB5",
      "doi-asserted-by": "crossref",
      "first-page": "11280",
      "DOI": "10.1021/bi00503a018",
      "article-title": "Catalytic activities of human liver cytochrome P-450 IIIA4 expressed in Saccharomyces cerevisiae",
      "volume": "29",
      "author": "Brian",
      "year": "1990",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "511",
      "DOI": "10.1111/j.1365-2125.1995.tb04488.x",
      "article-title": "Interphenotype differences in disposition and effect on gastrin levels of omeprazole-suitability of omeprazole as a probe for CYP2C19",
      "volume": "39",
      "author": "Chang",
      "year": "1995",
      "journal-title": "Br. J. Clin. Pharmacol."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "83",
      "DOI": "10.1016/S0021-9258(18)48462-1",
      "article-title": "Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins interred from comparative analyses of amino acid and coding nucleotide sequences",
      "volume": "267",
      "author": "Gotoh",
      "year": "1992",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB8",
      "doi-asserted-by": "crossref",
      "first-page": "1092",
      "DOI": "10.1021/jm00374a027",
      "article-title": "The preferred solution conformation of warfarin at the active site of cytochrome P-450 based on the CD spectra in octanol/water model system",
      "volume": "27",
      "author": "Heimark",
      "year": "1984",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "388",
      "DOI": "10.1038/clpt.1987.168",
      "article-title": "The mechanism ot the warfarin-rifampin drug interaction in humans",
      "volume": "42",
      "author": "Heimark",
      "year": "1987",
      "journal-title": "Clin. Pharmacol. Ther."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "3365",
      "DOI": "10.1016/0006-2952(89)90635-7",
      "article-title": "The in vitro ketone reduction of warfarin and analogues. Substrate stercoselectivity, product stereoselectivity and species differences",
      "volume": "38",
      "author": "Hermans",
      "year": "1989",
      "journal-title": "Biochem. Pharmacol."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB11",
      "first-page": "268",
      "article-title": "Stereoselective acetonyl side chain reduction of warfarin and analogs: partial characterization of two cytosolic carbonyl reductases",
      "volume": "20",
      "author": "Hermans",
      "year": "1992",
      "journal-title": "Drug Metab. Dispos."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "482",
      "DOI": "10.1111/j.1476-5381.1993.tb13836.x",
      "article-title": "Human liver microsomal metabolism of the enantiomers of warfarin and acenocoumarol: P450 isozyme diversity determines the differences in their pharmacokinetics",
      "volume": "110",
      "author": "Hermans",
      "year": "1993",
      "journal-title": "Br. J. Pharmacol."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "275",
      "DOI": "10.1016/0006-2952(92)90010-G",
      "article-title": "Effect of age and gender on the activity ot human hepatic CYP3A",
      "volume": "44",
      "author": "Hunt",
      "year": "1992",
      "journal-title": "Biochem. Pharmacol."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "902",
      "DOI": "10.1021/ja01234a019",
      "article-title": "Studies on 4-hydroxycoumarins. V. The condensation of alpha, beta-unsaturated ketones with 4-hydroxycoumarin",
      "volume": "66",
      "author": "Ikawa",
      "year": "1944",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "155",
      "DOI": "10.1016/0009-9236(95)90193-0",
      "article-title": "Comparison of the interaction potential of a new proton pump inhibitor, E3810, versus omeprazole with diazepam in extensive and poor metabolizers of S-mephenytoin 4\u2032-hydroxylation",
      "volume": "58",
      "author": "Ishizaki",
      "year": "1995",
      "journal-title": "Clin. Pharmacol. Ther."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "251",
      "DOI": "10.1093/clinids/22.2.251",
      "article-title": "Effect of ciprofloxacin on the pharmacokinetics and pharmacodynamics of warfarin",
      "volume": "22",
      "author": "Israel",
      "year": "1996",
      "journal-title": "Clin. Infect. Dis."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB17",
      "first-page": "209",
      "article-title": "Phase II metabolism of warfarin in primary culture of adult rat hepatocytes",
      "volume": "41",
      "author": "Jansing",
      "year": "1992",
      "journal-title": "Mol. Pharmacol."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB18",
      "first-page": "260",
      "article-title": "Putative active site template model for cytochrome P4502C9 (tobutamide hydroxyalse)",
      "volume": "24",
      "author": "Jones",
      "year": "1996",
      "journal-title": "Drug Metab. Dispos."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "479",
      "DOI": "10.3109/03602538909103554",
      "article-title": "Warfarin as a probe of cytochromes P-450 function",
      "volume": "20",
      "author": "Kaminsky",
      "year": "1989",
      "journal-title": "Drug Metab. Rev."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB20",
      "first-page": "470",
      "article-title": "Human hepatic cytochrome P-450 composition as probed by in vitro microsomal metabolism of warfarin",
      "volume": "12",
      "author": "Kaminsky",
      "year": "1984",
      "journal-title": "Drug Metab. Dispos."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB21",
      "first-page": "234",
      "article-title": "Correlation of human cytochrome P4502C substrate specificities with primary structure: warfarin as a probe",
      "volume": "43",
      "author": "Kaminsky",
      "year": "1993",
      "journal-title": "Mol. Pharmacol."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB22",
      "first-page": "183",
      "article-title": "Cytochrome P450: probes of active site residue",
      "author": "Kaminsky",
      "year": "1993"
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "305",
      "DOI": "10.1038/clpt.1987.152",
      "article-title": "Interaction between warfarin and propafenone in healthy volunteer subjects",
      "volume": "42",
      "author": "Kates",
      "year": "1987",
      "journal-title": "Clin. Pharmacol. Ther."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "24",
      "DOI": "10.1002/chir.530030106",
      "article-title": "Metabolic enantiomeric interactions: the inhibition of human (S)-warfarin-7-hydroxylase by (R)-warfarin",
      "volume": "3",
      "author": "Kunze",
      "year": "1991",
      "journal-title": "Chirality"
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "1607",
      "DOI": "10.1172/JCI107711",
      "article-title": "Warfarin, stereochemical aspects of metabolism and the interaction with phenylbutazone",
      "volume": "53",
      "author": "Lewis",
      "year": "1974",
      "journal-title": "J. Clin. Invest."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB26",
      "first-page": "673",
      "article-title": "Rifampicin induction of lidocaine metabolism in cultured human hepatocytes",
      "volume": "274",
      "author": "Li",
      "year": "1995",
      "journal-title": "J. Pharmacol. Exp. Ther."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB27",
      "doi-asserted-by": "crossref",
      "first-page": "10365",
      "DOI": "10.1021/bi00033a007",
      "article-title": "The substrate binding site of human liver cytochrome P4502C9: an approach using designed tienilic acid derivatives and molecular modeling",
      "volume": "34",
      "author": "Mancy",
      "year": "1995",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "1953",
      "DOI": "10.1016/0006-2952(75)90381-0",
      "article-title": "Studies on a ketone reductase in human and rat liver and kidney soluble fraction using warfarin as a substrate",
      "volume": "24",
      "author": "Moreland",
      "year": "1975",
      "journal-title": "Biochem. Pharmacol."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB29",
      "first-page": "259",
      "article-title": "Role of hydrogen-bonding in substrate structure-activity relationships tor CYP2C9",
      "volume": "Vol. 8",
      "author": "Morsman",
      "year": "1995"
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1097/00008571-199602000-00002",
      "article-title": "P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature",
      "volume": "6",
      "author": "Nelson",
      "year": "1996",
      "journal-title": "Pharmacogenetics"
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "215",
      "DOI": "10.1016/0003-9861(92)90160-X",
      "article-title": "Azidowarfarin photoaffinity probes of purified rat liver cytochrome P4501A1",
      "volume": "294",
      "author": "Obach",
      "year": "1992",
      "journal-title": "Arch. Biochem. Biophys."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "506",
      "DOI": "10.7326/0003-4819-83-4-506",
      "article-title": "Interaction of chronic daily warfarin therapy and rifampin",
      "volume": "83",
      "author": "O'Reilly",
      "year": "1975",
      "journal-title": "Ann. Intern. Med."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "354",
      "DOI": "10.1056/NEJM197608122950702",
      "article-title": "The stereoselective interaction of warfarin and metronidazole in man",
      "volume": "295",
      "author": "O'Reilly",
      "year": "1976",
      "journal-title": "N. Engl. J. Med."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB34",
      "first-page": "691",
      "article-title": "Comparative interaction of sulfinpyrazone and phenylbutazone with racemic warfarin: alteration in vivo of free fraction of plasma warfarin",
      "volume": "219",
      "author": "O'Reilly",
      "year": "1981",
      "journal-title": "J. Pharmacol. Exp. Ther."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "290",
      "DOI": "10.1038/clpt.1987.149",
      "article-title": "Interaction of amiodarone with racemic warfarin and its separated enantiomorphs in humans",
      "volume": "42",
      "author": "O'Reilly",
      "year": "1987",
      "journal-title": "Clin. Pharmacol. Ther."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB36",
      "doi-asserted-by": "crossref",
      "first-page": "573",
      "DOI": "10.1111/j.1365-2125.1994.tb04399.x",
      "article-title": "Inhibition of caffeine metabolism by ciprofloxacin in children with cystic fibrosis as measured by the caffeine breath test",
      "volume": "38",
      "author": "Parker",
      "year": "1994",
      "journal-title": "Br. J. Clin. Pharmacol."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB37",
      "series-title": "Casarett and Doull's Toxicology: The Basic Science of Poisons",
      "first-page": "113",
      "article-title": "Biotransformation of xenobtotics",
      "author": "Parkinson",
      "year": "1996"
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB38",
      "first-page": "265",
      "article-title": "Characteristics of warfarin hydroxylation catalyzed by human liver microsomes",
      "volume": "17",
      "author": "Rettie",
      "year": "1989",
      "journal-title": "Drug Metab. Dispos."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB39",
      "doi-asserted-by": "crossref",
      "first-page": "54",
      "DOI": "10.1021/tx00025a009",
      "article-title": "Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions",
      "volume": "5",
      "author": "Rettie",
      "year": "1992",
      "journal-title": "Chem. Res. Toxicol."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "39",
      "DOI": "10.1097/00008571-199402000-00005",
      "article-title": "Impaired (S)-warfarin metabolism catalysed by the R144C allelic variant of CYP2C9",
      "volume": "4",
      "author": "Rettie",
      "year": "1994",
      "journal-title": "Pharmacogenetics"
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB41",
      "doi-asserted-by": "crossref",
      "first-page": "1549",
      "DOI": "10.1093/carcin/16.7.1549",
      "article-title": "Cytochromes P450 in cynomolgus monkeys mutagenically activate 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) but not 2-amino-3,8-dimethyl-imidazo[4,5-f]quinoxaline (MeIQx)",
      "volume": "16",
      "author": "Sadrieh",
      "year": "1995",
      "journal-title": "Carcinogenesis"
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB42",
      "doi-asserted-by": "crossref",
      "first-page": "380",
      "DOI": "10.1177/000331975300400410",
      "article-title": "Warfarin sodium derivative (coumadin sodium): intravenous hypoprothrombinemia-inducing agent",
      "volume": "4",
      "author": "Shapiro",
      "year": "1953",
      "journal-title": "Angiology"
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB43",
      "first-page": "414",
      "article-title": "Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians",
      "volume": "270",
      "author": "Shimada",
      "year": "1994",
      "journal-title": "J. Pharmacol. Exp. Ther."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB44",
      "doi-asserted-by": "crossref",
      "first-page": "168",
      "DOI": "10.1002/j.1552-4604.1996.tb04182.x",
      "article-title": "Enbancement of anticoagulant action by wartarin-benzbromarone interaction",
      "volume": "36",
      "author": "Shimodaira",
      "year": "1996",
      "journal-title": "J. Clin. Pharmacol."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB45",
      "doi-asserted-by": "crossref",
      "first-page": "15",
      "DOI": "10.1111/j.1365-2125.1994.tb04316.x",
      "article-title": "The effect of enzyme inhibition on the metabolism and activation of tacrine by human liver microsomes",
      "volume": "38",
      "author": "Spaldin",
      "year": "1994",
      "journal-title": "Br. J. Clin. Pharmacol."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB46",
      "doi-asserted-by": "crossref",
      "first-page": "341",
      "DOI": "10.1097/00008571-199608000-00007",
      "article-title": "The role of the CYP2C9-Ile359 allelic variant in the tolbutamide polymorphism",
      "volume": "6",
      "author": "Sullivan",
      "year": "1996",
      "journal-title": "Pharmacogenetics"
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB47",
      "doi-asserted-by": "crossref",
      "first-page": "176",
      "DOI": "10.1097/00007691-198903000-00010",
      "article-title": "Stereoselective interaction of omeprazole with warfarin in healthy men",
      "volume": "11",
      "author": "Sutfin",
      "year": "1989",
      "journal-title": "Ther. Drug Monit."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB48",
      "doi-asserted-by": "crossref",
      "first-page": "15",
      "DOI": "10.1038/clpt.1986.3",
      "article-title": "The warfarin-sulfin-pyrazone interaction: stereochemical considerations",
      "volume": "39",
      "author": "Toon",
      "year": "1986",
      "journal-title": "Clin. Pharmacol. Ther."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB49",
      "doi-asserted-by": "crossref",
      "first-page": "33",
      "DOI": "10.1038/clpt.1987.104",
      "article-title": "Enoxacin-warfarin interaction: pharmacokinetic and stereochemical aspects",
      "volume": "42",
      "author": "Toon",
      "year": "1987",
      "journal-title": "Clin. Pharmacol. Ther."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB50",
      "doi-asserted-by": "crossref",
      "first-page": "489",
      "DOI": "10.3109/03602538909103555",
      "article-title": "Stereochemistry of cytochrome P-450 reactions",
      "volume": "20",
      "author": "Trager",
      "year": "1989",
      "journal-title": "Drug Metab. Rev."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB51",
      "doi-asserted-by": "crossref",
      "first-page": "1196",
      "DOI": "10.1021/jm00300a041",
      "article-title": "Mass spectral analysis in the identification of human metabolites of warfarin",
      "volume": "13",
      "author": "Trager",
      "year": "1970",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB52",
      "doi-asserted-by": "crossref",
      "first-page": "509",
      "DOI": "10.1111/j.1365-2125.1992.tb05656.x",
      "article-title": "A study of the interaction of omeprazole and warfarin in anticoagulated patients",
      "volume": "34",
      "author": "Unge",
      "year": "1992",
      "journal-title": "Br. J. Clin. Pharmacol."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB53",
      "doi-asserted-by": "crossref",
      "first-page": "5375",
      "DOI": "10.1021/bi00292a019",
      "article-title": "Purification and characterization of six cytochrome P-450 isozymes from human liver microsomes",
      "volume": "22",
      "author": "Wang",
      "year": "1983",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB54",
      "doi-asserted-by": "crossref",
      "first-page": "676",
      "DOI": "10.7326/0003-4819-121-9-199411010-00009",
      "article-title": "Interactions of warfarin with drugs and food",
      "volume": "121",
      "author": "Wells",
      "year": "1994",
      "journal-title": "Ann. Intern. Med."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB55",
      "first-page": "610",
      "article-title": "The formation of (R)-8-hydroxywarfarin in human liver microsomes: a new metabolic marker tor the (S)-mephenytoin hydroxylase, P4502C19",
      "volume": "24",
      "author": "Wienkers",
      "year": "1996",
      "journal-title": "Drug Metab. Dispos."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB56",
      "first-page": "1339",
      "article-title": "Human cytochromes P4501A1 and P4501A2: R-warfarin metabolism as a probe",
      "volume": "23",
      "author": "Zbang",
      "year": "1995",
      "journal-title": "Drug Metab. Dispos."
    },
    {
      "key": "10.1016/S0163-7258(96)00140-4_BIB57",
      "first-page": "3926",
      "article-title": "Characterization of purified human recombinant CYP1A1-Ile462 and Val462: assessment of a role for the rare allele in carcinogenesis",
      "volume": "56",
      "author": "Zhang",
      "year": "1996",
      "journal-title": "Cancer Res."
    }
  ],
  "container-title": "Pharmacology &amp; Therapeutics",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0163725896001404?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0163725896001404?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        5,
        13
      ]
    ],
    "date-time": "2021-05-13T05:53:07Z",
    "timestamp": 1620885187000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0163725896001404"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1997,
        1
      ]
    ]
  },
  "references-count": 57,
  "journal-issue": {
    "issue": "1",
    "published-print": {
      "date-parts": [
        [
          1997,
          1
        ]
      ]
    }
  },
  "alternative-id": [
    "S0163725896001404"
  ],
  "URL": "http://dx.doi.org/10.1016/S0163-7258(96)00140-4",
  "relation": {},
  "ISSN": [
    "0163-7258"
  ],
  "subject": [],
  "container-title-short": "Pharmacology &amp; Therapeutics",
  "published": {
    "date-parts": [
      [
        1997,
        1
      ]
    ]
  }
}