Crossref journal-article
Elsevier BV
Cell (78)
Bibliography

Rock, K. L., Gramm, C., Rothstein, L., Clark, K., Stein, R., Dick, L., Hwang, D., & Goldberg, A. L. (1994). Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell, 78(5), 761–771.

Authors 8
  1. Kenneth L. Rock (first)
  2. Colette Gramm (additional)
  3. Lisa Rothstein (additional)
  4. Karen Clark (additional)
  5. Ross Stein (additional)
  6. Lawrence Dick (additional)
  7. Daniel Hwang (additional)
  8. Alfred L. Goldberg (additional)
References 45 Referenced 2,026
  1. 10.1038/360171a0 / Nature / Proteasome subunits encoded in the MHC are not generally required for the processing of peptides bound by MHC class I molecules by Arnold (1992)
  2. {'key': '10.1016/S0092-8674(94)90462-6_bib2', 'series-title': 'A hypothesis', 'first-page': '75', 'article-title': 'T cellrecognized antigenic peptides derived from the cellular genome are not protein degradation products but can be generated directly by transcription and translation of short subgenic regions', 'volume': '29', 'author': 'Boon', 'year': '1989'} / A hypothesis / T cellrecognized antigenic peptides derived from the cellular genome are not protein degradation products but can be generated directly by transcription and translation of short subgenic regions by Boon (1989)
  3. 10.1111/j.1600-065X.1987.tb00521.x / Immunol. Rev. / Antigen presentation pathways to class I and class II MHC-restricted T lymphocytes by Braciale (1987)
  4. 10.1007/BF00166829 / Immunogenetics / Efficient expression of tum-antigen P91A by transfected subgenic fragments by Chomez (1992)
  5. 10.1016/0092-8674(84)90300-3 / Cell / Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85 by Ciechanover (1984)
  6. 10.1096/fasebj.1.5.2824267 / FASEB J. / Molecular determinants of protein half-lives in eukaryotic cells by Dice (1987)
  7. 10.1016/S0021-9258(19)34041-4 / J. Biol. Chem. / The proteasome (multicatalytic protease) is a component of the 1500-kDa proteolytic complex which degrades ubiquitin-conjugated proteins by Driscoll (1990)
  8. 10.1038/365262a0 / Nature / MHC-linked LMP gene products specifically alter peptidase activities of the proteasome by Driscoll (1993)
  9. 10.4049/jimmunol.147.8.2697 / J. Immunol. / A frameshift mutation at the NH2 terminus of the nucleoprotein gene does not affect generation of cytotoxic T lymphocyte epitopes by Fetten (1991)
  10. 10.1038/365264a0 / Nature / Gamma-interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes by Gaczynska (1993)
  11. 10.1146/annurev.iy.11.040193.002155 / Annu. Rev. Immunol. / The biochemistry and cell biology of antigen processing and presentation by Germain (1993)
  12. 10.1111/j.1432-1033.1992.tb19822.x / Eur. J. Biochem. / The mechanism and functions of ATP-dependent proteases in bacterial and animal cells by Goldberg (1992)
  13. 10.1038/357375a0 / Nature / Proteolysis, proteosomes and antigen presentation by Goldberg (1992)
  14. 10.1146/annurev.bi.45.070176.003531 / Annu. Rev. Biochem. / Intracellular protein degradation in mammalian and bacterial cells by Goldberg (1976)
  15. 10.1016/S0021-9258(19)83626-8 / J. Biol. Chem. / The ATP dependence of the degradation of short- and long-lived proteins in growing fibroblasts by Gronostajski (1985)
  16. 10.1016/S0021-9258(19)67837-3 / J. Biol. Chem. / The ubiquitin-activating enzyme, E1, is required for stress-induced lysosomal degradation of cellular proteins by Gropper (1991)
  17. {'key': '10.1016/S0092-8674(94)90462-6_bib17', 'series-title': 'Serological characterization and reactivity with B and T lymphocytes', 'first-page': '433', 'article-title': 'Isolation of twelve monoclonal antibodies against Ia and H-2 antigens', 'volume': '8', 'author': 'Hämmerling', 'year': '1979'} / Serological characterization and reactivity with B and T lymphocytes / Isolation of twelve monoclonal antibodies against Ia and H-2 antigens by Hämmerling (1979)
  18. 10.1146/annurev.bi.61.070192.003553 / Annu. Rev. Biochem. / The ubiquitin system for protein degradation by Hershko (1992)
  19. 10.1016/S0021-9258(18)55308-4 / J. Biol. Chem. / Methylated ubiquitin inhibits cyclin degradation in clam embryo extracts by Hershko (1991)
  20. 10.1038/292547a0 / Nature / Cooperative interaction of B lymphocytes with antigen-specific helper T lymphocytes is MHC restricted by Jones (1981)
  21. {'key': '10.1016/S0092-8674(94)90462-6_bib21', 'first-page': '3604', 'article-title': 'Antigen presentation by Ia+ B cell hybridomas to H-2-restricted T cell hybridomas', 'volume': '79', 'author': 'Kappler', 'year': '1982'} / Antigen presentation by Ia+ B cell hybridomas to H-2-restricted T cell hybridomas by Kappler (1982)
  22. 10.1038/319675a0 / Nature / Selective rejection of H-2 deficient lymphoma variants suggests alternative immune defense strategy by Kärre (1986)
  23. 10.1038/363552a0 / Nature / A role for the ubiquitin-dependent proteolytic pathway in MHC class Irestricted antigen presentation by Michalek (1993)
  24. 10.1016/0167-5699(92)90122-N / Immunol. Today / A molecular model of MHC class-I-restricted antigen processing by Monaco (1992)
  25. 10.1016/S0092-8674(88)91043-4 / Cell / Introduction of soluble protein into the class I pathway of antigen processing and presentation by Moore (1988)
  26. 10.1016/0014-5793(91)80686-W / FEBS Lett. / ATP-dependent reversible association of proteasomes with multiple protein components to form 26S complexes that degrade ubiquitinated proteins in human HL-60 cells by Orino (1991)
  27. 10.1021/bi00497a001 / Biochemistry / The multicatalytic proteinase complex, a major extralysosomal proteolytic system by Orlowski (1990)
  28. 10.4049/jimmunol.126.1.317 / J. Immunol. / Monoclonal antibodies to mouse MHC antigens. III. Hybridoma antibodies reacting to antigens of the H-2b haplotype reveal genetic control of isotype expression by Ozato (1980)
  29. 10.1146/annurev.cb.03.110187.000245 / Annu. Rev. Cell Biol. / Ubiquitin-mediated pathways for intracellular proteolysis by Rechsteiner (1987)
  30. 10.1016/S0021-9258(18)53218-X / J. Biol. Chem. / The multicatalytic and 26 S proteases by Rechsteiner (1993)
  31. 10.1042/bj2910001 / Biochem. J. / Proteasomes: multicatalytic proteinase complexes by Rivett (1993)
  32. 10.1084/jem.157.5.1618 / J. Exp. Med. / Inhibition of antigen-specific T lymphocyte activation by structurally related Ir gene controlled polymers: evidence of specific competition for accessory cell antigen-presentation by Rock (1983)
  33. 10.4049/jimmunol.145.3.804 / J. Immunol. / Generation of class I MHC-restricted T-T hybridomas by Rock (1990)
  34. 10.1016/0092-8674(91)90093-E / Cell / Dissociation of β2-microglobulin leads to the accumulation of a substantial pool of inactive class I MHC heavy chains on the cell surface by Rock (1991)
  35. 10.3109/14756369009035837 / J. Enzyme Inhib. / Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins by Sasaki (1990)
  36. 10.1002/j.1460-2075.1990.tb08141.x / EMBO J. / Ubiquitin-conjugating enzymes UBC4 and UBC5 mediate selective degradation of short-lived and abnormal proteins by Seufert (1990)
  37. 10.1002/j.1460-2075.1992.tb05379.x / EMBO J. / In vivo function of the proteasome in the ubiquitin pathway by Seufert (1992)
  38. {'key': '10.1016/S0092-8674(94)90462-6_bib38', 'first-page': '3353', 'article-title': 'In vivo inhibition of cyclin B degradation and induction of cell-cycle arrest in mammalian cells by the neutral cysteine protease inhibitor N-acetylleucylleucylnorleucinal', 'volume': '90', 'author': 'Sherwood', 'year': '1993'} / In vivo inhibition of cyclin B degradation and induction of cell-cycle arrest in mammalian cells by the neutral cysteine protease inhibitor N-acetylleucylleucylnorleucinal by Sherwood (1993)
  39. 10.1016/0161-5890(90)90112-D / Mol. Immunol. / The conformational flexibility of class I H-2 molecules as revealed by anti-peptide antibodies specific for intracytoplasmic determinants: differential reactivity of beta-2 microblobulin “bound” and “free” heavy chains by Smith (1990)
  40. 10.1016/0014-5793(91)80856-X / FEBS Lett. / Improved method for preparation of ubiquitin-ligated lysoszyme as substrate of ATP-dependent proteolysis by Tamura (1991)
  41. {'key': '10.1016/S0092-8674(94)90462-6_bib41', 'first-page': 'E326', 'article-title': 'Dietary protein deficiency reduces lysosomal and nonlysosomal ATP-dependent proteolysis in muscle', 'volume': '263', 'author': 'Tawa', 'year': '1992', 'journal-title': 'Am. J. Physiol.'} / Am. J. Physiol. / Dietary protein deficiency reduces lysosomal and nonlysosomal ATP-dependent proteolysis in muscle by Tawa (1992)
  42. 10.1006/scel.1993.1007 / Semin. Cell Biol. / The transporters associated with antigen presentation by Townsend (1993)
  43. 10.1016/0092-8674(90)90366-M / Cell / Assembly of MHC class I molecules analyzed in vitro by Townsend (1990)
  44. 10.1006/bbrc.1993.2378 / Biochem. Biophys. Res. Commun. / Purification and characterization of a ZLeuLeuLeupMCA degrading protease expected to regulate neurite formation: a novel catalytic activity in proteasome by Tsubuki (1993)
  45. 10.1021/bi00154a014 / Biochemistry / Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex by Vinitsky (1992)
Dates
Type When
Created 20 years, 10 months ago (Oct. 4, 2004, 1:02 p.m.)
Deposited 2 years, 3 months ago (April 29, 2023, 8:31 a.m.)
Indexed 2 weeks, 3 days ago (Aug. 5, 2025, 8:13 a.m.)
Issued 30 years, 11 months ago (Sept. 1, 1994)
Published 30 years, 11 months ago (Sept. 1, 1994)
Published Print 30 years, 11 months ago (Sept. 1, 1994)
Funders 0

None

@article{Rock_1994, title={Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules}, volume={78}, ISSN={0092-8674}, url={http://dx.doi.org/10.1016/s0092-8674(94)90462-6}, DOI={10.1016/s0092-8674(94)90462-6}, number={5}, journal={Cell}, publisher={Elsevier BV}, author={Rock, Kenneth L. and Gramm, Colette and Rothstein, Lisa and Clark, Karen and Stein, Ross and Dick, Lawrence and Hwang, Daniel and Goldberg, Alfred L.}, year={1994}, month=sep, pages={761–771} }