DOI: 10.1016/s0092-8674(05)80066-2. FGF inactivates myogenic helix-loop-helix proteins through phosphorylation of a conserved protein kinase C site in their DNA-binding domains

FGF inactivates myogenic helix-loop-helix proteins through phosphorylation of a conserved protein kinase C site in their DNA-binding domains

10.1016/s0092-8674(05)80066-2

Crossref journal-article

Elsevier BV

Cell (78)

Bibliography

Li, L., Zhou, J., James, G., Heller-Harrison, R., Czech, M. P., & Olson, E. N. (1992). FGF inactivates myogenic helix-loop-helix proteins through phosphorylation of a conserved protein kinase C site in their DNA-binding domains. Cell, 71(7), 1181â1194.

Authors 6

Li Li (first)
Jumin Zhou (additional)
Guy James (additional)
Robin Heller-Harrison (additional)
Michael P. Czech (additional)
Eric N. Olson (additional)

References 66 Referenced 259

{'key': '10.1016/S0092-8674(05)80066-2_bib1', 'first-page': '3377', 'article-title': '12-O-Tetradecanoylphorbol-13-acetate-induced differentiation of a human rhabdomyosarcoma cell line', 'volume': '50', 'author': 'Aguanno', 'year': '1990', 'journal-title': 'Cancer Res.'} / Cancer Res. / 12-O-Tetradecanoylphorbol-13-acetate-induced differentiation of a human rhabdomyosarcoma cell line by Aguanno (1990)
10.1016/S0021-9258(19)67698-2 / J. Biol. Chem. / Lipid activation of protein kinase C. by Bell (1991)
10.1016/0092-8674(90)90214-Y / Cell / The protein Id: a negative regulator of helix-loop-helix DNA binding proteins by Benezra (1990)
10.1016/0092-8674(92)90187-H / Cell. / Functional antagonism between C-Jun and MyoD proteins: a direct physical association by Bengal (1992)
10.1038/351122a0 / Nature / Ha-Ras augments cJun activity and stimulates phosphorylation of its activation domain by Binetruy (1991)
10.1016/0092-8674(91)90241-P / Cell / Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity by Boyle (1991)
10.1002/j.1460-2075.1989.tb03429.x / EMBO J. / A novel human muscle factor related to but distinct from MyoD1 induces myogenic conversion in 10T1/2 fibroblasts by Braun (1989)
10.1101/gad.4.4.582 / Genes Dev. / Myogenin resides in the nucleus and acquires high affinity for a conserved enhancer element on heterodimerization by Brennan (1990)
{'key': '10.1016/S0092-8674(05)80066-2_bib9', 'first-page': '5675', 'article-title': 'Mutagenesis of the myogenin basic region identifies an ancient protein motif cricital for activation of myogenesis', 'volume': '88', 'author': 'Brennan', 'year': '1991'} / Mutagenesis of the myogenin basic region identifies an ancient protein motif cricital for activation of myogenesis by Brennan (1991)
{'key': '10.1016/S0092-8674(05)80066-2_bib10', 'first-page': '3822', 'article-title': 'Transforming growth factor β represses the actions of myogenin through a mechanism independent of DNA binding', 'volume': '88', 'author': 'Brennan', 'year': '1991'} / Transforming growth factor β represses the actions of myogenin through a mechanism independent of DNA binding by Brennan (1991)
10.1128/MCB.9.6.2627 / Mol. Cell. Biol. / Identification of a myocyte nuclear factor that binds to the muscle-specific enhancer of the mouse muscle creatine kinase gene by Buskin (1989)
10.1128/MCB.11.7.3633 / Mol. Cell. Biol. / Inefficient homooligomerization contributes to the dependence of myogenin on E2A products for efficient DNA binding by Chakraborty (1991)
10.1016/S0021-9258(18)49929-2 / J. Biol. Chem. / Differential trans-activation of a muscle-specific enhancer by myogenic helix-loop-helix proteins is separable from DNA binding by Chakraborty (1991)
10.1083/jcb.105.2.949 / J. Cell Biol. / Growth factor control of skeletal muscle differentiation commitment to terminal differentiation occurs in G phase and is repressed by fibroblast growth factor by Clegg (1987)
10.1038/266538a0 / Nature / Effect of a tumour promoter on myogenesis by Cohen (1977)
10.1242/dev.115.4.1087 / Development / MHox: a mesodermally-restricted homeodomain protein that binds an essential site in the muscle creatine kinase enhancer by Cserjesi (1992)
10.1016/0092-8674(90)90088-V / Cell / The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation by Davis (1990)
10.1126/science.1317057 / Science / Acquisition of myogenic specificity by replacement of three amino acid residues from MyoD into E12 by Davis (1992)
10.1016/0092-8674(87)90585-X / Cell / Expression of a single transfected cDNA converts fibroblasts to myoblasts by Davis (1987)
{'key': '10.1016/S0092-8674(05)80066-2_bib20', 'first-page': '1283', 'article-title': 'Myogenic regulatory protein (MyoD1) expression in childhood solid tumors, diagnostic utility in rhabdomyosarcoma', 'volume': '137', 'author': 'Dias', 'year': '1991', 'journal-title': 'Am. J. Pathol.'} / Am. J. Pathol. / Myogenic regulatory protein (MyoD1) expression in childhood solid tumors, diagnostic utility in rhabdomyosarcoma by Dias (1991)
10.1101/gad.3.5.628 / Genes Dev. / A gene with homology to the myc similarity region of MyoD1 is expressed during myogenesis and is sufficient to activate the muscle differentiation program by Edmondson (1989)
10.1016/S0021-9258(18)54640-8 / J. Biol. Chem. / Mitogenic repression of myogenin autoregulation by Edmondson (1991)
{'key': '10.1016/S0092-8674(05)80066-2_bib23', 'article-title': 'High efficiency gene transfer into mammalian cells', 'volume': 'Vol. 2', 'author': 'Gorman', 'year': '1985'} / High efficiency gene transfer into mammalian cells by Gorman (1985)
10.1128/MCB.9.11.5022 / Mol. Cell. Biol. / A new myocyte-specific enhancer-binding factor that recognizes a conserved element associated with multiple muscle-specific genes by Gossett (1989)
10.1128/MCB.9.11.4722 / Mol. Cell. Biol. / Expression of the MyoD1 muscle determination gene defines differentiation capability but not tumorigenicity of human rhabdomyosarcomas by Hiti (1989)
10.1016/S0021-9258(18)52396-6 / J. Biol. Chem. / Selective translocation of βII-protein kinase C to the nucleus of human promyelocytic (HL60) leukemia cells by Hocevar (1991)
10.1002/j.1460-2075.1989.tb08505.x / EMBO J. / MyoD expression in the forming somites is an early response to mesoderm induction in Xenopus by Hopwood (1989)
10.1016/S0092-8674(88)80027-8 / Cell / Overproduction of protein kinase C causes disordered growth control in rat fibroblasts by Housey (1988)
10.1128/MCB.12.3.1031 / Mol. Cell. Biol. / HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors by Hu (1992)
10.1016/0092-8674(92)90162-6 / Cell / The regulation of transcription by phosphorylation by Hunter (1992)
10.1083/jcb.116.4.863 / J. Cell Biol. / Deletion of the regulatory domain of protein kinase C α exposes regions in the hinge and catalytic domains that mediate nuclear targeting by James (1992)
10.1016/S0021-9258(18)80023-0 / J. Biol. Chem. / Molecular genetic analysis of the regulatory and catalytic domains of protein kinase C by Kaibuchi (1989)
10.1016/0968-0004(90)90073-K / Trends Biochem. Sci. / Protein kinase recognition sequence motifs by Kemp (1990)
10.1016/S0021-9258(18)42157-6 / J. Biol. Chem. / Inhibition of protein phosphatases blocks myogenesis by first altering MyoD binding activity by Kim (1992)
{'key': '10.1016/S0092-8674(05)80066-2_bib35', 'first-page': '473', 'article-title': 'Inhibition of myogenic differentiation by the H-ras oncogene is associated with the down regulation of the MyoD1 gene', 'volume': '4', 'author': 'Konieczny', 'year': '1989', 'journal-title': 'Oncogene'} / Oncogene / Inhibition of myogenic differentiation by the H-ras oncogene is associated with the down regulation of the MyoD1 gene by Konieczny (1989)
10.1016/0092-8674(89)90935-5 / Cell / MyoD is a sequence-specific DNA binding protein requiring a region of myc homology to bind to the muscle creatine kinase enhancer by Lassar (1989)
10.1016/0092-8674(89)90101-3 / Cell / Transformation by activated ras or fos prevents myogenesis by inhibiting expression of MyoD1 by Lassar (1989)
10.1016/0092-8674(91)90620-E / Cell / Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo by Lassar (1991)
10.1083/jcb.109.2.685 / J. Cell Biol. / Type 3 protein kinaseC localization to the nuclear envelope of phorbol ester-treated NIH 3T3 cells by Leach (1989)
10.1101/gad.6.4.676 / Genes Dev. / Fos and Jun repress transcriptional activation by myogenin and MyoD: the amino terminus of Jun can mediate repression by Li (1992)
10.1128/MCB.12.10.4478 / Mol. Cell. Biol. / cAMP-dependent protein kinase inhibits the activity of myogenic helix-loop-helix proteins by Li (1992)
10.1016/S0021-9258(19)49859-1 / J. Biol. Chem. / Repression of myogenin function by TGF-β1 is targeted at the basic helix-loop-helix motif and is independent of E2A products by Martin (1992)
10.1126/science.2814500 / Science / In vivo footprinting of a muscle-specific enhancer by ligation-mediated PCR by Mueller (1989)
10.1016/0092-8674(89)90434-0 / Cell / Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence by Murre (1989)
10.1101/gad.4.9.1454 / Genes Dev. / The MyoD family, a paradigm for development? by Olson (1990)
10.1016/0012-1606(92)90066-P / Dev. Biol. / Interplay between proliferation and differentiation within the myogenic lineage by Olson (1992)
10.1128/MCB.7.6.2104 / Mol. Cell Biol. / The oncogenic forms of N-ras or H-ras prevent skeletal myoblast differentiation by Olson (1987)
{'key': '10.1016/S0092-8674(05)80066-2_bib48', 'first-page': '495', 'article-title': 'Role of Raf1 serine-threonine protein kinase in growth factor signal transduction', 'volume': '6', 'author': 'Rapp', 'year': '1991', 'journal-title': 'Oncogene'} / Oncogene / Role of Raf1 serine-threonine protein kinase in growth factor signal transduction by Rapp (1991)
10.1101/gad.3.12b.2050 / Genes Dev. / Identification of MRF4: a new member of the muscle regulatory factor gene family by Rhodes (1989)
10.1038/341303a0 / Nature / Expression of two myogenic regulatory factors myogenin and MyoD1 during mouse embryogenesis by Sassoon (1989)
10.1016/S0021-9258(18)67682-3 / J. Biol. Chem. / Serum and fibroblast growth factor inhibit myogenic differentiation through a mechanism dependent on protein synthesis and independent of cell proliferation by Spizz (1986)
10.1128/MCB.8.7.2896 / Mol. Cell Biol. / Identification of upstream and intragenic regulatory elements that confer cell-type-restricted and differntiation-specific expression on the muscle creatine kinase gene by Sternberg (1988)
10.1126/science.3175662 / Science / MyoD1: a nuclear phosphoprotein requiring a myc homology region to convert fibroblasts to myoblasts by Tapscott (1988)
10.1016/0092-8674(89)90838-6 / Cell / Positive autoregulation of the myogenic determination gene MyoD1 by Thayer (1989)
{'key': '10.1016/S0092-8674(05)80066-2_bib55', 'first-page': '5100', 'article-title': 'Muscle-specific gene expression in rhabdomyosarcomas and stages of human fetal skeletal muscle development', 'volume': '51', 'author': 'Tonin', 'year': '1991', 'journal-title': 'Cancer Res.'} / Cancer Res. / Muscle-specific gene expression in rhabdomyosarcomas and stages of human fetal skeletal muscle development by Tonin (1991)
10.1016/0014-5793(85)80009-0 / FEBS Lett. / Induction of protein kinase C activation and Ca2+ mobilization by fibroblast growth factor in Swiss 3T3 cells by Tsuda (1985)
10.1083/jcb.114.4.809 / J. Cell. Biol. / Inhibition of myogenesis by the H-ras oncogene: implication of a role for protein kinase C by Vaidya (1991)
{'key': '10.1016/S0092-8674(05)80066-2_bib58', 'first-page': '396', 'article-title': 'Molecular model for DNA recognition by the family of basic- helix-loop-helix-zipper proteins', 'volume': '4', 'author': 'Vinson', 'year': '1992', 'journal-title': 'New Biol.'} / New Biol. / Molecular model for DNA recognition by the family of basic- helix-loop-helix-zipper proteins by Vinson (1992)
{'key': '10.1016/S0092-8674(05)80066-2_bib59', 'first-page': '5623', 'article-title': 'MyoD binds cooperatively to two sites in a target enhancer sequence: occupancy of two sites is required for activation', 'volume': '87', 'author': 'Weintraub', 'year': '1990'} / MyoD binds cooperatively to two sites in a target enhancer sequence: occupancy of two sites is required for activation by Weintraub (1990)
10.1126/science.1846704 / Science / The myoD gene family: nodal point during specification of the muscle cell lineage by Weintraub (1991)
10.1101/gad.5.8.1377 / Genes Dev. / Muscle-specific transcriptional activation by myoD by Weintraub (1991)
10.1038/325359a0 / Nature / Elevated levels of diacylglycerol and decreased phorbol ester sensitivity in ras-transformed fibroblasts by Wolfman (1987)
10.1111/j.1432-1033.1986.tb10139.x / Eur. J. Biochem. / Substrate specificity of protein kinase C: Use of synthetic peptides corresponding to physiological sites as probes for substrate recognition requirements by Woodgett (1986)
10.1016/0092-8674(89)90583-7 / Cell / Myogenin, a factor regulating myogenesis, has a domain homologous to MyoD by Wright (1989)
10.1128/MCB.10.8.3934 / Mol. Cell. Biol. / Differential trans activation associated with the muscle regulatory factors MyoD1, myogenin, and MRF4 by Yutzey (1990)
10.1083/jcb.115.3.745 / J. Cell Biol. / Phorbol esters selectively downregulate contractile protein gene expression in terminally differentiated myotubes through transcriptional repression and message destabilization by Zhu (1991)

Dates

Type	When
Created	19 years, 9 months ago (Nov. 11, 2005, 7:14 a.m.)
Deposited	4 years, 1 month ago (July 19, 2021, 11:11 a.m.)
Indexed	2 days, 17 hours ago (Sept. 3, 2025, 6:05 a.m.)
Issued	32 years, 9 months ago (Dec. 1, 1992)
Published	32 years, 9 months ago (Dec. 1, 1992)
Published Print	32 years, 9 months ago (Dec. 1, 1992)

Funders 0

None

BibTeX

@article{Li_1992, title={FGF inactivates myogenic helix-loop-helix proteins through phosphorylation of a conserved protein kinase C site in their DNA-binding domains}, volume={71}, ISSN={0092-8674}, url={http://dx.doi.org/10.1016/s0092-8674(05)80066-2}, DOI={10.1016/s0092-8674(05)80066-2}, number={7}, journal={Cell}, publisher={Elsevier BV}, author={Li, Li and Zhou, Jumin and James, Guy and Heller-Harrison, Robin and Czech, Michael P. and Olson, Eric N.}, year={1992}, month=dec, pages={1181–1194} }

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      "author": "Bengal",
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      "journal-title": "Cell."
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      "author": "Davis",
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      "key": "10.1016/S0092-8674(05)80066-2_bib20",
      "first-page": "1283",
      "article-title": "Myogenic regulatory protein (MyoD1) expression in childhood solid tumors, diagnostic utility in rhabdomyosarcoma",
      "volume": "137",
      "author": "Dias",
      "year": "1991",
      "journal-title": "Am. J. Pathol."
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "628",
      "DOI": "10.1101/gad.3.5.628",
      "article-title": "A gene with homology to the myc similarity region of MyoD1 is expressed during myogenesis and is sufficient to activate the muscle differentiation program",
      "volume": "3",
      "author": "Edmondson",
      "year": "1989",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "21343",
      "DOI": "10.1016/S0021-9258(18)54640-8",
      "article-title": "Mitogenic repression of myogenin autoregulation",
      "volume": "266",
      "author": "Edmondson",
      "year": "1991",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib23",
      "article-title": "High efficiency gene transfer into mammalian cells",
      "volume": "Vol. 2",
      "author": "Gorman",
      "year": "1985"
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "5022",
      "DOI": "10.1128/MCB.9.11.5022",
      "article-title": "A new myocyte-specific enhancer-binding factor that recognizes a conserved element associated with multiple muscle-specific genes",
      "volume": "9",
      "author": "Gossett",
      "year": "1989",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "4722",
      "DOI": "10.1128/MCB.9.11.4722",
      "article-title": "Expression of the MyoD1 muscle determination gene defines differentiation capability but not tumorigenicity of human rhabdomyosarcomas",
      "volume": "9",
      "author": "Hiti",
      "year": "1989",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "28",
      "DOI": "10.1016/S0021-9258(18)52396-6",
      "article-title": "Selective translocation of \u03b2II-protein kinase C to the nucleus of human promyelocytic (HL60) leukemia cells",
      "volume": "266",
      "author": "Hocevar",
      "year": "1991",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "3409",
      "DOI": "10.1002/j.1460-2075.1989.tb08505.x",
      "article-title": "MyoD expression in the forming somites is an early response to mesoderm induction in Xenopus",
      "volume": "8",
      "author": "Hopwood",
      "year": "1989",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "343",
      "DOI": "10.1016/S0092-8674(88)80027-8",
      "article-title": "Overproduction of protein kinase C causes disordered growth control in rat fibroblasts",
      "volume": "52",
      "author": "Housey",
      "year": "1988",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "1031",
      "DOI": "10.1128/MCB.12.3.1031",
      "article-title": "HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors",
      "volume": "12",
      "author": "Hu",
      "year": "1992",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "375",
      "DOI": "10.1016/0092-8674(92)90162-6",
      "article-title": "The regulation of transcription by phosphorylation",
      "volume": "70",
      "author": "Hunter",
      "year": "1992",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "863",
      "DOI": "10.1083/jcb.116.4.863",
      "article-title": "Deletion of the regulatory domain of protein kinase C \u03b1 exposes regions in the hinge and catalytic domains that mediate nuclear targeting",
      "volume": "116",
      "author": "James",
      "year": "1992",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib32",
      "doi-asserted-by": "crossref",
      "first-page": "13489",
      "DOI": "10.1016/S0021-9258(18)80023-0",
      "article-title": "Molecular genetic analysis of the regulatory and catalytic domains of protein kinase C",
      "volume": "264",
      "author": "Kaibuchi",
      "year": "1989",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "342",
      "DOI": "10.1016/0968-0004(90)90073-K",
      "article-title": "Protein kinase recognition sequence motifs",
      "volume": "15",
      "author": "Kemp",
      "year": "1990",
      "journal-title": "Trends Biochem. Sci."
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "15140",
      "DOI": "10.1016/S0021-9258(18)42157-6",
      "article-title": "Inhibition of protein phosphatases blocks myogenesis by first altering MyoD binding activity",
      "volume": "267",
      "author": "Kim",
      "year": "1992",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib35",
      "first-page": "473",
      "article-title": "Inhibition of myogenic differentiation by the H-ras oncogene is associated with the down regulation of the MyoD1 gene",
      "volume": "4",
      "author": "Konieczny",
      "year": "1989",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib36",
      "doi-asserted-by": "crossref",
      "first-page": "823",
      "DOI": "10.1016/0092-8674(89)90935-5",
      "article-title": "MyoD is a sequence-specific DNA binding protein requiring a region of myc homology to bind to the muscle creatine kinase enhancer",
      "volume": "58",
      "author": "Lassar",
      "year": "1989",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib37",
      "doi-asserted-by": "crossref",
      "first-page": "659",
      "DOI": "10.1016/0092-8674(89)90101-3",
      "article-title": "Transformation by activated ras or fos prevents myogenesis by inhibiting expression of MyoD1",
      "volume": "58",
      "author": "Lassar",
      "year": "1989",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib38",
      "doi-asserted-by": "crossref",
      "first-page": "305",
      "DOI": "10.1016/0092-8674(91)90620-E",
      "article-title": "Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo",
      "volume": "66",
      "author": "Lassar",
      "year": "1991",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib39",
      "doi-asserted-by": "crossref",
      "first-page": "685",
      "DOI": "10.1083/jcb.109.2.685",
      "article-title": "Type 3 protein kinaseC localization to the nuclear envelope of phorbol ester-treated NIH 3T3 cells",
      "volume": "109",
      "author": "Leach",
      "year": "1989",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib40",
      "doi-asserted-by": "crossref",
      "first-page": "676",
      "DOI": "10.1101/gad.6.4.676",
      "article-title": "Fos and Jun repress transcriptional activation by myogenin and MyoD: the amino terminus of Jun can mediate repression",
      "volume": "6",
      "author": "Li",
      "year": "1992",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib41",
      "doi-asserted-by": "crossref",
      "first-page": "4478",
      "DOI": "10.1128/MCB.12.10.4478",
      "article-title": "cAMP-dependent protein kinase inhibits the activity of myogenic helix-loop-helix proteins",
      "volume": "12",
      "author": "Li",
      "year": "1992",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib42",
      "doi-asserted-by": "crossref",
      "first-page": "10956",
      "DOI": "10.1016/S0021-9258(19)49859-1",
      "article-title": "Repression of myogenin function by TGF-\u03b21 is targeted at the basic helix-loop-helix motif and is independent of E2A products",
      "volume": "267",
      "author": "Martin",
      "year": "1992",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib43",
      "doi-asserted-by": "crossref",
      "first-page": "780",
      "DOI": "10.1126/science.2814500",
      "article-title": "In vivo footprinting of a muscle-specific enhancer by ligation-mediated PCR",
      "volume": "246",
      "author": "Mueller",
      "year": "1989",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib44",
      "doi-asserted-by": "crossref",
      "first-page": "537",
      "DOI": "10.1016/0092-8674(89)90434-0",
      "article-title": "Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence",
      "volume": "58",
      "author": "Murre",
      "year": "1989",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib45",
      "doi-asserted-by": "crossref",
      "first-page": "1454",
      "DOI": "10.1101/gad.4.9.1454",
      "article-title": "The MyoD family, a paradigm for development?",
      "volume": "4",
      "author": "Olson",
      "year": "1990",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib46",
      "doi-asserted-by": "crossref",
      "DOI": "10.1016/0012-1606(92)90066-P",
      "article-title": "Interplay between proliferation and differentiation within the myogenic lineage",
      "author": "Olson",
      "year": "1992",
      "journal-title": "Dev. Biol."
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib47",
      "doi-asserted-by": "crossref",
      "first-page": "2104",
      "DOI": "10.1128/MCB.7.6.2104",
      "article-title": "The oncogenic forms of N-ras or H-ras prevent skeletal myoblast differentiation",
      "volume": "7",
      "author": "Olson",
      "year": "1987",
      "journal-title": "Mol. Cell Biol."
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib48",
      "first-page": "495",
      "article-title": "Role of Raf1 serine-threonine protein kinase in growth factor signal transduction",
      "volume": "6",
      "author": "Rapp",
      "year": "1991",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib49",
      "doi-asserted-by": "crossref",
      "first-page": "2050",
      "DOI": "10.1101/gad.3.12b.2050",
      "article-title": "Identification of MRF4: a new member of the muscle regulatory factor gene family",
      "volume": "3",
      "author": "Rhodes",
      "year": "1989",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib50",
      "doi-asserted-by": "crossref",
      "first-page": "303",
      "DOI": "10.1038/341303a0",
      "article-title": "Expression of two myogenic regulatory factors myogenin and MyoD1 during mouse embryogenesis",
      "volume": "341",
      "author": "Sassoon",
      "year": "1989",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib51",
      "doi-asserted-by": "crossref",
      "first-page": "9483",
      "DOI": "10.1016/S0021-9258(18)67682-3",
      "article-title": "Serum and fibroblast growth factor inhibit myogenic differentiation through a mechanism dependent on protein synthesis and independent of cell proliferation",
      "volume": "261",
      "author": "Spizz",
      "year": "1986",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib52",
      "doi-asserted-by": "crossref",
      "first-page": "2896",
      "DOI": "10.1128/MCB.8.7.2896",
      "article-title": "Identification of upstream and intragenic regulatory elements that confer cell-type-restricted and differntiation-specific expression on the muscle creatine kinase gene",
      "volume": "8",
      "author": "Sternberg",
      "year": "1988",
      "journal-title": "Mol. Cell Biol."
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib53",
      "doi-asserted-by": "crossref",
      "first-page": "405",
      "DOI": "10.1126/science.3175662",
      "article-title": "MyoD1: a nuclear phosphoprotein requiring a myc homology region to convert fibroblasts to myoblasts",
      "volume": "242",
      "author": "Tapscott",
      "year": "1988",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib54",
      "doi-asserted-by": "crossref",
      "first-page": "241",
      "DOI": "10.1016/0092-8674(89)90838-6",
      "article-title": "Positive autoregulation of the myogenic determination gene MyoD1",
      "volume": "58",
      "author": "Thayer",
      "year": "1989",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib55",
      "first-page": "5100",
      "article-title": "Muscle-specific gene expression in rhabdomyosarcomas and stages of human fetal skeletal muscle development",
      "volume": "51",
      "author": "Tonin",
      "year": "1991",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib56",
      "doi-asserted-by": "crossref",
      "first-page": "205",
      "DOI": "10.1016/0014-5793(85)80009-0",
      "article-title": "Induction of protein kinase C activation and Ca2+ mobilization by fibroblast growth factor in Swiss 3T3 cells",
      "volume": "191",
      "author": "Tsuda",
      "year": "1985",
      "journal-title": "FEBS Lett."
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib57",
      "doi-asserted-by": "crossref",
      "first-page": "809",
      "DOI": "10.1083/jcb.114.4.809",
      "article-title": "Inhibition of myogenesis by the H-ras oncogene: implication of a role for protein kinase C",
      "volume": "114",
      "author": "Vaidya",
      "year": "1991",
      "journal-title": "J. Cell. Biol."
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib58",
      "first-page": "396",
      "article-title": "Molecular model for DNA recognition by the family of basic- helix-loop-helix-zipper proteins",
      "volume": "4",
      "author": "Vinson",
      "year": "1992",
      "journal-title": "New Biol."
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib59",
      "first-page": "5623",
      "article-title": "MyoD binds cooperatively to two sites in a target enhancer sequence: occupancy of two sites is required for activation",
      "volume": "87",
      "author": "Weintraub",
      "year": "1990"
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib60",
      "doi-asserted-by": "crossref",
      "first-page": "761",
      "DOI": "10.1126/science.1846704",
      "article-title": "The myoD gene family: nodal point during specification of the muscle cell lineage",
      "volume": "251",
      "author": "Weintraub",
      "year": "1991",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib61",
      "doi-asserted-by": "crossref",
      "first-page": "1377",
      "DOI": "10.1101/gad.5.8.1377",
      "article-title": "Muscle-specific transcriptional activation by myoD",
      "volume": "5",
      "author": "Weintraub",
      "year": "1991",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib62",
      "doi-asserted-by": "crossref",
      "first-page": "359",
      "DOI": "10.1038/325359a0",
      "article-title": "Elevated levels of diacylglycerol and decreased phorbol ester sensitivity in ras-transformed fibroblasts",
      "volume": "325",
      "author": "Wolfman",
      "year": "1987",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib63",
      "doi-asserted-by": "crossref",
      "first-page": "177",
      "DOI": "10.1111/j.1432-1033.1986.tb10139.x",
      "article-title": "Substrate specificity of protein kinase C: Use of synthetic peptides corresponding to physiological sites as probes for substrate recognition requirements",
      "volume": "161",
      "author": "Woodgett",
      "year": "1986",
      "journal-title": "Eur. J. Biochem."
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib64",
      "doi-asserted-by": "crossref",
      "first-page": "607",
      "DOI": "10.1016/0092-8674(89)90583-7",
      "article-title": "Myogenin, a factor regulating myogenesis, has a domain homologous to MyoD",
      "volume": "56",
      "author": "Wright",
      "year": "1989",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(05)80066-2_bib65",
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      "first-page": "3934",
      "DOI": "10.1128/MCB.10.8.3934",
      "article-title": "Differential trans activation associated with the muscle regulatory factors MyoD1, myogenin, and MRF4",
      "volume": "10",
      "author": "Yutzey",
      "year": "1990",
      "journal-title": "Mol. Cell. Biol."
    },
    {
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      "first-page": "745",
      "DOI": "10.1083/jcb.115.3.745",
      "article-title": "Phorbol esters selectively downregulate contractile protein gene expression in terminally differentiated myotubes through transcriptional repression and message destabilization",
      "volume": "115",
      "author": "Zhu",
      "year": "1991",
      "journal-title": "J. Cell Biol."
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