DOI: 10.1016/s0092-8674(03)00716-5. Homer Binds TRPC Family Channels and Is Required for Gating of TRPC1 by IP3 Receptors

Homer Binds TRPC Family Channels and Is Required for Gating of TRPC1 by IP3 Receptors

10.1016/s0092-8674(03)00716-5

Crossref journal-article

Elsevier BV

Cell (78)

Bibliography

Yuan, J. P., Kiselyov, K., Shin, D. M., Chen, J., Shcheynikov, N., Kang, S. H., Dehoff, M. H., Schwarz, M. K., Seeburg, P. H., Muallem, S., & Worley, P. F. (2003). Homer Binds TRPC Family Channels and Is Required for Gating of TRPC1 by IP3 Receptors. Cell, 114(6), 777â789.

Authors 11

Joseph P Yuan (first)
Kirill Kiselyov (additional)
Dong Ming Shin (additional)
Jin Chen (additional)
Nikolay Shcheynikov (additional)
Shin H Kang (additional)
Marlin H Dehoff (additional)
Martin K Schwarz (additional)
Peter H Seeburg (additional)
Shmuel Muallem (additional)
Paul F Worley (additional)

References 33 Referenced 417

10.1074/jbc.272.15.10151 / J. Biol. Chem. / The P2U purinoceptor obligatorily engages the heterotrimeric G protein G16 to mobilize intracellular Ca2+ in human erythroleukemia cells by Baltensperger (1997)
10.1016/S0896-6273(00)81145-9 / Neuron / Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition by Beneken (2000)
10.1073/pnas.96.26.14955 / Proc. Natl. Acad. Sci. USA / Modulation of Ca(2+) entry by polypeptides of the inositol 1,4, 5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP) by Boulay (1999)
10.1038/386284a0 / Nature / Homer by Brakeman (1997)
{'key': '10.1016/S0092-8674(03)00716-5_BIB5', 'series-title': "Homer as both a scaffold and transduction molecule. Science's STKE", 'author': 'Fagni', 'year': '2002'} / Homer as both a scaffold and transduction molecule. Science's STKE by Fagni (2002)
10.1074/jbc.M207675200 / J. Biol. Chem. / Homer regulates gain of ryanodine receptor type 1 channel complex by Feng (2002)
10.1073/pnas.102596199 / Proc. Natl. Acad. Sci. USA / Subunit composition of mammalian transient receptor potential channels in living cells by Hofmann (2002)
10.1016/S0022-2836(02)00170-5 / J. Mol. Biol. / Crystal structure of the Homer 1 family conserved region reveals the interaction between the EVH1 domain and own proline-rich motif by Irie (2002)
10.1038/24890 / Nature / Functional interaction between InsP3 receptors and store-operated Htrp3 channels by Kiselyov (1998)
10.1016/S1097-2765(00)80344-5 / Mol. Cell / The N-terminal domain of the IP3 receptor gates store-operated hTrp3 channels by Kiselyov (1999)
10.1038/sj.onc.1206245 / Oncogene / Exchange of catenins in cadherin-catenin complex by Klingelhofer (2003)
10.1074/jbc.275.5.3403 / J. Biol. Chem. / Trp1, a candidate protein for the store-operated Ca(2+) influx mechanism in salivary gland cells by Liu (2000)
10.1152/physrev.00001.2002 / Physiol. Rev. / TRP channel proteins and signal transduction by Minke (2002)
{'key': '10.1016/S0092-8674(03)00716-5_BIB14', 'series-title': "Physiology, phylogeny, and functions of the TRP superfamily of cation channels. Science's STKE", 'author': 'Montell', 'year': '2001'} / Physiology, phylogeny, and functions of the TRP superfamily of cation channels. Science's STKE by Montell (2001)
10.1016/S0092-8674(02)00670-0 / Cell / The TRP channels, a remarkably functional family by Montell (2002)
10.1091/mbc.7.6.949 / Mol. Biol. Cell / Inositol 1,4,5-trisphosphate receptors in endocrine cells by Nucifora (1996)
10.1038/35070704 / Nature / Cell biology. Channelling calcium by Putney (2001)
10.1038/75973 / Nat. Genet. / High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP by Rodriguez (2000)
10.1093/nar/23.24.5080 / Nucleic Acids Res. / A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells by Schwenk (1995)
10.1083/jcb.200210109 / J. Cell Biol. / Homer 2 tunes G protein-coupled receptors stimulus intensity by regulating RGS proteins and PLC{beta} GAP activities by Shin (2003)
10.1006/jmbi.1999.3436 / J. Mol. Biol. / Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing by Soloviev (2000)
10.1046/j.1432-1327.2000.01078.x / Eur. J. Biochem. / Mouse brain and muscle tissues constitutively express high levels of Homer proteins by Soloviev (2000)
10.1016/S0896-6273(01)00240-9 / Neuron / TRPC1 and TRPC5 form a novel cation channel in mammalian brain by Strubing (2001)
10.1074/jbc.M102316200 / J. Biol. Chem. / Identification of common binding sites for calmodulin and inositol 1,4,5-trisphosphate receptors on the carboxyl termini of trp channels by Tang (2001)
10.1016/S0896-6273(00)80589-9 / Neuron / Homer binds a novel proline rich motif and links group1 metabotropic glutamate receptors with IP3 receptors by Tu (1998)
10.1016/S0896-6273(00)80810-7 / Neuron / mGluR/Homer and PSD-95 complexes are linked by the shank family of postsynaptic density proteins by Tu (1999)
10.1074/jbc.M204531200 / J. Biol. Chem. / Calmodulin modulates the delay period between release of calcium from internal stores and activation of calcium influx via endogenous TRP1 channels by Vaca (2002)
10.1523/JNEUROSCI.22-23-10067.2002 / J. Neurosci. / Experience-dependent coincident expression of the effector immediate-early genes arc and Homer 1a in hippocampal and neocortical neuronal networks by Vazdarjanova (2002)
10.1074/jbc.C100321200 / J. Biol. Chem. / Expression of functional receptor-coupled TRPC3 channels in DT40 triple receptor InsP3 knockout cells by Venkatachalam (2001)
10.1038/ncb1102-e263 / Nat. Cell Biol. / The cellular and molecular basis of store-operated calcium entry by Venkatachalam (2002)
10.1016/S0143-4160(02)00055-6 / Cell Calcium / Current understanding of mammalian TRP homologues by Vennekens (2002)
10.1016/S0896-6273(00)80588-7 / Neuron / Homer regulates the association of Group 1 metabotropic receptors with multivalent complexes of Homer-related, synaptic proteins by Xiao (1998)
10.1016/S0959-4388(00)00087-8 / Curr. Opin. Neurobiol. / Homer by Xiao (2000)

Dates

Type	When
Created	21 years, 4 months ago (April 17, 2004, 2:47 p.m.)
Deposited	6 years, 6 months ago (Feb. 13, 2019, 6:51 a.m.)
Indexed	1 month, 1 week ago (July 27, 2025, 3:50 a.m.)
Issued	22 years ago (Sept. 1, 2003)
Published	22 years ago (Sept. 1, 2003)
Published Print	22 years ago (Sept. 1, 2003)

Funders 0

None

BibTeX

@article{Yuan_2003, title={Homer Binds TRPC Family Channels and Is Required for Gating of TRPC1 by IP3 Receptors}, volume={114}, ISSN={0092-8674}, url={http://dx.doi.org/10.1016/s0092-8674(03)00716-5}, DOI={10.1016/s0092-8674(03)00716-5}, number={6}, journal={Cell}, publisher={Elsevier BV}, author={Yuan, Joseph P and Kiselyov, Kirill and Shin, Dong Ming and Chen, Jin and Shcheynikov, Nikolay and Kang, Shin H and Dehoff, Marlin H and Schwarz, Martin K and Seeburg, Peter H and Muallem, Shmuel and Worley, Paul F}, year={2003}, month=sep, pages={777–789} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        27
      ]
    ],
    "date-time": "2025-07-27T07:50:25Z",
    "timestamp": 1753602625374
  },
  "reference-count": 33,
  "publisher": "Elsevier BV",
  "issue": "6",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2003,
            9,
            1
          ]
        ],
        "date-time": "2003-09-01T00:00:00Z",
        "timestamp": 1062374400000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2013,
            7,
            17
          ]
        ],
        "date-time": "2013-07-17T00:00:00Z",
        "timestamp": 1374019200000
      },
      "content-version": "vor",
      "delay-in-days": 3607,
      "URL": "https://www.elsevier.com/open-access/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2003,
        9
      ]
    ]
  },
  "DOI": "10.1016/s0092-8674(03)00716-5",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2004,
        4,
        17
      ]
    ],
    "date-time": "2004-04-17T18:47:25Z",
    "timestamp": 1082227645000
  },
  "page": "777-789",
  "source": "Crossref",
  "is-referenced-by-count": 417,
  "title": "Homer Binds TRPC Family Channels and Is Required for Gating of TRPC1 by IP3 Receptors",
  "prefix": "10.1016",
  "volume": "114",
  "author": [
    {
      "given": "Joseph P",
      "family": "Yuan",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Kirill",
      "family": "Kiselyov",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Dong Ming",
      "family": "Shin",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Jin",
      "family": "Chen",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Nikolay",
      "family": "Shcheynikov",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Shin H",
      "family": "Kang",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Marlin H",
      "family": "Dehoff",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Martin K",
      "family": "Schwarz",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Peter H",
      "family": "Seeburg",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Shmuel",
      "family": "Muallem",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Paul F",
      "family": "Worley",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/S0092-8674(03)00716-5_BIB1",
      "doi-asserted-by": "crossref",
      "first-page": "10151",
      "DOI": "10.1074/jbc.272.15.10151",
      "article-title": "The P2U purinoceptor obligatorily engages the heterotrimeric G protein G16 to mobilize intracellular Ca2+ in human erythroleukemia cells",
      "volume": "272",
      "author": "Baltensperger",
      "year": "1997",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(03)00716-5_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "143",
      "DOI": "10.1016/S0896-6273(00)81145-9",
      "article-title": "Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition",
      "volume": "26",
      "author": "Beneken",
      "year": "2000",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/S0092-8674(03)00716-5_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "14955",
      "DOI": "10.1073/pnas.96.26.14955",
      "article-title": "Modulation of Ca(2+) entry by polypeptides of the inositol 1,4, 5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP)",
      "volume": "96",
      "author": "Boulay",
      "year": "1999",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(03)00716-5_BIB4",
      "doi-asserted-by": "crossref",
      "first-page": "284",
      "DOI": "10.1038/386284a0",
      "article-title": "Homer",
      "volume": "386",
      "author": "Brakeman",
      "year": "1997",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(03)00716-5_BIB5",
      "series-title": "Homer as both a scaffold and transduction molecule. Science's STKE",
      "author": "Fagni",
      "year": "2002"
    },
    {
      "key": "10.1016/S0092-8674(03)00716-5_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "44722",
      "DOI": "10.1074/jbc.M207675200",
      "article-title": "Homer regulates gain of ryanodine receptor type 1 channel complex",
      "volume": "277",
      "author": "Feng",
      "year": "2002",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(03)00716-5_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "7461",
      "DOI": "10.1073/pnas.102596199",
      "article-title": "Subunit composition of mammalian transient receptor potential channels in living cells",
      "volume": "99",
      "author": "Hofmann",
      "year": "2002",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(03)00716-5_BIB8",
      "doi-asserted-by": "crossref",
      "first-page": "1117",
      "DOI": "10.1016/S0022-2836(02)00170-5",
      "article-title": "Crystal structure of the Homer 1 family conserved region reveals the interaction between the EVH1 domain and own proline-rich motif",
      "volume": "318",
      "author": "Irie",
      "year": "2002",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/S0092-8674(03)00716-5_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "478",
      "DOI": "10.1038/24890",
      "article-title": "Functional interaction between InsP3 receptors and store-operated Htrp3 channels",
      "volume": "396",
      "author": "Kiselyov",
      "year": "1998",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(03)00716-5_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "423",
      "DOI": "10.1016/S1097-2765(00)80344-5",
      "article-title": "The N-terminal domain of the IP3 receptor gates store-operated hTrp3 channels",
      "volume": "4",
      "author": "Kiselyov",
      "year": "1999",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/S0092-8674(03)00716-5_BIB11",
      "doi-asserted-by": "crossref",
      "first-page": "1181",
      "DOI": "10.1038/sj.onc.1206245",
      "article-title": "Exchange of catenins in cadherin-catenin complex",
      "volume": "22",
      "author": "Klingelhofer",
      "year": "2003",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/S0092-8674(03)00716-5_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "3403",
      "DOI": "10.1074/jbc.275.5.3403",
      "article-title": "Trp1, a candidate protein for the store-operated Ca(2+) influx mechanism in salivary gland cells",
      "volume": "275",
      "author": "Liu",
      "year": "2000",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(03)00716-5_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "429",
      "DOI": "10.1152/physrev.00001.2002",
      "article-title": "TRP channel proteins and signal transduction",
      "volume": "82",
      "author": "Minke",
      "year": "2002",
      "journal-title": "Physiol. Rev."
    },
    {
      "key": "10.1016/S0092-8674(03)00716-5_BIB14",
      "series-title": "Physiology, phylogeny, and functions of the TRP superfamily of cation channels. Science's STKE",
      "author": "Montell",
      "year": "2001"
    },
    {
      "key": "10.1016/S0092-8674(03)00716-5_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "595",
      "DOI": "10.1016/S0092-8674(02)00670-0",
      "article-title": "The TRP channels, a remarkably functional family",
      "volume": "108",
      "author": "Montell",
      "year": "2002",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(03)00716-5_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "949",
      "DOI": "10.1091/mbc.7.6.949",
      "article-title": "Inositol 1,4,5-trisphosphate receptors in endocrine cells",
      "volume": "7",
      "author": "Nucifora",
      "year": "1996",
      "journal-title": "Mol. Biol. Cell"
    },
    {
      "key": "10.1016/S0092-8674(03)00716-5_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "648",
      "DOI": "10.1038/35070704",
      "article-title": "Cell biology. Channelling calcium",
      "volume": "410",
      "author": "Putney",
      "year": "2001",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(03)00716-5_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "139",
      "DOI": "10.1038/75973",
      "article-title": "High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP",
      "volume": "25",
      "author": "Rodriguez",
      "year": "2000",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "10.1016/S0092-8674(03)00716-5_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "5080",
      "DOI": "10.1093/nar/23.24.5080",
      "article-title": "A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells",
      "volume": "23",
      "author": "Schwenk",
      "year": "1995",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "10.1016/S0092-8674(03)00716-5_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "293",
      "DOI": "10.1083/jcb.200210109",
      "article-title": "Homer 2 tunes G protein-coupled receptors stimulus intensity by regulating RGS proteins and PLC{beta} GAP activities",
      "volume": "162",
      "author": "Shin",
      "year": "2003",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/S0092-8674(03)00716-5_BIB21",
      "doi-asserted-by": "crossref",
      "first-page": "1185",
      "DOI": "10.1006/jmbi.1999.3436",
      "article-title": "Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing",
      "volume": "295",
      "author": "Soloviev",
      "year": "2000",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/S0092-8674(03)00716-5_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "634",
      "DOI": "10.1046/j.1432-1327.2000.01078.x",
      "article-title": "Mouse brain and muscle tissues constitutively express high levels of Homer proteins",
      "volume": "267",
      "author": "Soloviev",
      "year": "2000",
      "journal-title": "Eur. J. Biochem."
    },
    {
      "key": "10.1016/S0092-8674(03)00716-5_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "645",
      "DOI": "10.1016/S0896-6273(01)00240-9",
      "article-title": "TRPC1 and TRPC5 form a novel cation channel in mammalian brain",
      "volume": "29",
      "author": "Strubing",
      "year": "2001",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/S0092-8674(03)00716-5_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "21303",
      "DOI": "10.1074/jbc.M102316200",
      "article-title": "Identification of common binding sites for calmodulin and inositol 1,4,5-trisphosphate receptors on the carboxyl termini of trp channels",
      "volume": "276",
      "author": "Tang",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(03)00716-5_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "717",
      "DOI": "10.1016/S0896-6273(00)80589-9",
      "article-title": "Homer binds a novel proline rich motif and links group1 metabotropic glutamate receptors with IP3 receptors",
      "volume": "21",
      "author": "Tu",
      "year": "1998",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/S0092-8674(03)00716-5_BIB26",
      "doi-asserted-by": "crossref",
      "first-page": "583",
      "DOI": "10.1016/S0896-6273(00)80810-7",
      "article-title": "mGluR/Homer and PSD-95 complexes are linked by the shank family of postsynaptic density proteins",
      "volume": "23",
      "author": "Tu",
      "year": "1999",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/S0092-8674(03)00716-5_BIB27",
      "doi-asserted-by": "crossref",
      "first-page": "42178",
      "DOI": "10.1074/jbc.M204531200",
      "article-title": "Calmodulin modulates the delay period between release of calcium from internal stores and activation of calcium influx via endogenous TRP1 channels",
      "volume": "277",
      "author": "Vaca",
      "year": "2002",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(03)00716-5_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "10067",
      "DOI": "10.1523/JNEUROSCI.22-23-10067.2002",
      "article-title": "Experience-dependent coincident expression of the effector immediate-early genes arc and Homer 1a in hippocampal and neocortical neuronal networks",
      "volume": "22",
      "author": "Vazdarjanova",
      "year": "2002",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/S0092-8674(03)00716-5_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "33980",
      "DOI": "10.1074/jbc.C100321200",
      "article-title": "Expression of functional receptor-coupled TRPC3 channels in DT40 triple receptor InsP3 knockout cells",
      "volume": "276",
      "author": "Venkatachalam",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(03)00716-5_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "E263",
      "DOI": "10.1038/ncb1102-e263",
      "article-title": "The cellular and molecular basis of store-operated calcium entry",
      "volume": "4",
      "author": "Venkatachalam",
      "year": "2002",
      "journal-title": "Nat. Cell Biol."
    },
    {
      "key": "10.1016/S0092-8674(03)00716-5_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "253",
      "DOI": "10.1016/S0143-4160(02)00055-6",
      "article-title": "Current understanding of mammalian TRP homologues",
      "volume": "31",
      "author": "Vennekens",
      "year": "2002",
      "journal-title": "Cell Calcium"
    },
    {
      "key": "10.1016/S0092-8674(03)00716-5_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "707",
      "DOI": "10.1016/S0896-6273(00)80588-7",
      "article-title": "Homer regulates the association of Group 1 metabotropic receptors with multivalent complexes of Homer-related, synaptic proteins",
      "volume": "21",
      "author": "Xiao",
      "year": "1998",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/S0092-8674(03)00716-5_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "370",
      "DOI": "10.1016/S0959-4388(00)00087-8",
      "article-title": "Homer",
      "volume": "10",
      "author": "Xiao",
      "year": "2000",
      "journal-title": "Curr. Opin. Neurobiol."
    }
  ],
  "container-title": "Cell",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0092867403007165?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0092867403007165?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2019,
        2,
        13
      ]
    ],
    "date-time": "2019-02-13T11:51:07Z",
    "timestamp": 1550058667000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0092867403007165"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2003,
        9
      ]
    ]
  },
  "references-count": 33,
  "journal-issue": {
    "issue": "6",
    "published-print": {
      "date-parts": [
        [
          2003,
          9
        ]
      ]
    }
  },
  "alternative-id": [
    "S0092867403007165"
  ],
  "URL": "http://dx.doi.org/10.1016/S0092-8674(03)00716-5",
  "relation": {
    "has-review": [
      {
        "id-type": "doi",
        "id": "10.3410/f.1005884.199508",
        "asserted-by": "object"
      }
    ]
  },
  "ISSN": [
    "0092-8674"
  ],
  "subject": [],
  "container-title-short": "Cell",
  "published": {
    "date-parts": [
      [
        2003,
        9
      ]
    ]
  }
}