DOI: 10.1016/s0092-8674(03)00598-1. Architecture of the RNA Polymerase II-TFIIS Complex and Implications for mRNA Cleavage

Architecture of the RNA Polymerase II-TFIIS Complex and Implications for mRNA Cleavage

10.1016/s0092-8674(03)00598-1

Crossref journal-article

Elsevier BV

Cell (78)

Bibliography

Kettenberger, H., Armache, K.-J., & Cramer, P. (2003). Architecture of the RNA Polymerase II-TFIIS Complex and Implications for mRNA Cleavage. Cell, 114(3), 347â357.

Authors 3

Hubert Kettenberger (first)
Karim-Jean Armache (additional)
Patrick Cramer (additional)

References 63 Referenced 289

10.1073/pnas.1030608100 / Proc Natl Acad Sci USA / Architecture of initiation-competent 12-subunit RNA polymerase II by Armache (2003)
10.1074/jbc.272.23.14747 / J. Biol. Chem. / Transcription elongation through DNA arrest sites. A multistep process involving both RNA polymerase II subunit RPB9 and TFIIS by Awrey (1997)
10.1074/jbc.273.35.22595 / J. Biol. Chem. / Yeast transcript elongation factor (TFIIS), structure and function. II by Awrey (1998)
10.1002/j.1460-2075.1991.tb07917.x / EMBO J. / Structural basis for the 3′-5′ exonuclease activity of Escherichia coli DNA polymerase I by Beese (1991)
10.1074/jbc.M002595200 / J. Biol. Chem. / Structure of a conserved domain common to the transcription factors TFIIS, elongin A, and CRSP70 by Booth (2000)
10.1107/S0907444998003254 / Acta Crystallogr D / Crystallography & NMR system by Brunger (1998)
10.1111/j.1432-1033.1995.tb20622.x / Eur. J. Biochem. / High-level biosynthetic substitution of methionine in proteins by its analogs 2-aminohexanoic acid, selenomethionine, telluromethionine and ethionine in Escherichia coli by Budisa (1995)
10.1073/pnas.1130601100 / Proc. Natl. Acad. Sci. USA / Complete, 12-subunit RNA polymerase II at 4.1 Å resolution by Bushnell (2003)
10.1073/pnas.251664698 / Proc. Natl. Acad. Sci. USA / Structural basis of transcription by Bushnell (2002)
10.1016/S0076-6879(97)77027-7 / Meth. Enzymol. / Ribbons by Carson (1997)
10.1101/gad.12.24.3857 / Genes Dev. / The RNA cleavage activity of RNA polymerase III is mediated by an essential TFIIS-like subunit and is important for transcription termination by Chedin (1998)
10.1073/pnas.91.17.8087 / Proc. Natl. Acad. Sci. USA / Cleavage of the nascent transcript induced by TFIIS is insufficient to promote read-through of intrinsic blocks to elongation by RNA polymerase II by Cipres-Palacin (1994)
10.1016/S0959-440X(02)00294-4 / Curr Opin Struct Biol / Multisubunit RNA polymerases by Cramer (2002)
10.1002/bies.10127 / Bioessays / Common structural features of nucleic acid polymerases by Cramer (2002)
10.1126/science.288.5466.640 / Science / Architecture of RNA polymerase II and implications for the transcription mechanism by Cramer (2000)
10.1126/science.1059493 / Science / Structural basis of transcription by Cramer (2001)
10.1128/MCB.20.16.5960-5973.2000 / Mol. Cell. Biol. / Genetic interactions between TFIIS and the Swi-Snf chromatin-remodeling complex by Davie (2000)
10.1074/jbc.M207038200 / J. Biol. Chem. / The downstream DNA jaw of bacterial RNA polymerase facilitates both transcriptional initiation and pausing by Ederth (2002)
10.1016/S0167-4781(02)00454-2 / Biochim. Biophys. Acta / The many conformational states of RNA polymerase elongation complexes and their roles in the regulation of transcription by Erie (2002)
10.1016/S0167-4781(02)00459-1 / Biochim. Biophys. Acta / Promoting elongation with transcript cleavage stimulatory factors by Fish (2002)
10.1126/science.1059495 / Science / Structural basis of transcription by Gnatt (2001)
10.1074/jbc.270.51.30441 / J. Biol. Chem. / Variation in the size of nascent RNA cleavage products as a function of transcript length and elongation competence by Gu (1995)
10.1074/jbc.275.17.12393 / J. Biol. Chem. / Transcription factor S, a cleavage induction factor of the archaeal RNA polymerase by Hausner (2000)
10.1074/jbc.M004721200 / J. Biol. Chem. / RNA polymerase II subunit rpb9 regulates transcription elongation in vivo by Hemming (2000)
10.1016/S0021-9258(17)43705-7 / J. Biol. Chem. / Analysis of the stimulatory factor of RNA polymerase II in the initiation and elongation complex by Horikoshi (1984)
10.1101/gad.6.7.1342 / Genes Dev. / The RNA polymerase II ternary complex cleaves the nascent transcript in a 3′-5′ direction in the presence of elongation factor SII by Izban (1992)
10.1016/S0021-9258(18)31468-6 / J. Biol. Chem. / The increment of SII-facilitated transcript cleavage varies dramatically between elongation competent and incompletent RNA polymerase II ternary complexes by Izban (1993)
10.1016/S0021-9258(18)31467-4 / J. Biol. Chem. / SII-facilitated transcript cleavage in RNA polymerase II complexes stalled early after initiation occurs in primarily dinucleotide increments by Izban (1993)
10.1073/pnas.93.24.13677 / Proc. Natl. Acad. Sci. USA / Fidelity of RNA polymerase II transcription controlled by elongation factor TFIIS by Jeon (1996)
10.1073/pnas.91.19.9106 / Proc. Natl. Acad. Sci. USA / The transcription factor TFIIS zinc ribbon dipeptide Asp-Glu is critical for stimulation of elongation and RNA cleavage by RNA polymerase II by Jeon (1994)
10.1016/0092-8674(94)90314-X / Cell / Complexes of yeast RNA polymerase II and RNA are substrates for TFIIS-induced RNA cleavage by Johnson (1994)
10.1107/S0108767390010224 / Acta Crystallogr. / Improved methods for building protein models in electron density maps and the location of errors in these models by Jones (1991)
10.1146/annurev.bi.63.070194.004021 / Annu. Rev. Biochem. / Function and structure relationships in DNA polymerases by Joyce (1994)
10.1126/science.289.5479.619 / Science / A structural model of transcription elongation by Korzheva (2000)
10.1074/jbc.272.11.7201 / J. Biol. Chem. / Domain organization of Escherichia coli transcript cleavage factors GreA and GreB by Koulich (1997)
10.1073/pnas.93.8.3221 / Proc. Natl. Acad. Sci. USA / Protein-RNA interactions in the active center of transcription elongation complex by Markovtsov (1996)
10.1073/pnas.93.20.10604 / Proc. Natl. Acad. Sci. USA / Elongation factor TFIIS contains three structural domains by Morin (1996)
10.1107/S0108767393007597 / Acta Crystallogr. / AMoRe by Navaza (1994)
10.1074/jbc.M301103200 / J. Biol. Chem. / NTP-driven translocation by human RNA polymerase II by Nedialkov (2003)
10.1016/S0092-8674(00)80180-4 / Cell / The RNA-DNA hybrid maintains the register of transcription by preventing backtracking of RNA polymerase by Nudler (1997)
10.1074/jbc.273.35.22589 / J. Biol. Chem. / Yeast transcript elongation factor TFIIS, structure and function. I by Olmsted (1998)
10.1016/S0092-8674(03)00600-7 / Cell / Structure and function of the transcription elongation factor GreB bound to bacterial RNA polymerase by Opalka (2003)
10.1006/jmbi.2001.4842 / J. Mol. Biol. / Roles of RNA:DNA hybrid stability, RNA structure, and active site conformation in pausing by human RNA polymerase II by Palangat (2001)
10.1016/S1097-2765(02)00502-6 / Mol. Cell / Exchange of RNA polymerase II initiation and elongation factors during gene expression in vivo by Pokholok (2002)
10.1074/jbc.271.37.22301 / J. Biol. Chem. / Elongation factor SII contacts the 3′-end of RNA in the RNA polymerase II elongation complex by Powell (1996)
10.1021/bi00089a010 / Biochemistry / Novel zinc finger motif in the basal transcriptional machinery by Qian (1993)
10.1016/S0021-9258(19)50596-8 / J. Biol. Chem. / Elongation factor-dependent transcript shortening by template-engaged RNA polymerase II by Reines (1992)
10.1074/jbc.271.35.21549 / J. Biol. Chem. / Amanitin greatly reduces the rate of transcription by RNA polymerase II ternary complexes but fails to inhibit some transcript cleavage modes by Rudd (1996)
10.1073/pnas.91.17.8057 / Proc. Natl. Acad. Sci. USA / The active site of RNA polymerase II participates in transcript cleavage within arrested ternary complexes by Rudd (1994)
10.1126/science.277.5324.333 / Science / The Ras-RasGAP complex by Scheffzek (1997)
10.1021/bi00668a018 / Biochemistry / Purification of a factor from Ehrlich ascites tumor cells specifically stimulating RNA polymerase II by Sekimizu (1976)
10.1074/jbc.M202059200 / J. Biol. Chem. / Use of an in vivo reporter assay to test for transcriptional and translational fidelity in yeast by Shaw (2002)
10.1146/annurev.biochem.72.121801.161551 / Annu. Rev. Biochem. / The RNA polymerase II elongation complex by Shilatifard (2003)
10.1074/jbc.M005834200 / J. Biol. Chem. / Structural basis for the species-specific activity of TFIIS by Shimasaki (2000)
10.1093/emboj/cdg193 / EMBO J. / Unified two-metal mechanism of RNA synthesis and degradation by RNA polymerase by Sosunov (2003)
10.1038/373636a0 / Nature / Crystal structure of the GreA transcript cleavage factor from Escherichia coli by Stebbins (1995)
10.1016/S0092-8674(00)81191-5 / Cell / Transcriptional fidelity and proofreading by RNA polymerase II by Thomas (1998)
10.1038/nature752 / Nature / Crystal structure of a bacterial RNA polymerase holoenzyme at 2.6 A resolution by Vassylyev (2002)
10.1073/pnas.90.3.843 / Proc. Natl. Acad. Sci. USA / Identification of a 3′-5′ exonuclease activity associated with human RNA polymerase II by Wang (1993)
10.1074/jbc.M211197200 / J. Biol. Chem. / Intrinsic transcript cleavage in yeast RNA polymerase II elongation complexes by Weilbaecher (2003)
10.1002/(SICI)1521-1878(200004)22:4<327::AID-BIES3>3.0.CO;2-4 / Bioessays / Transcription elongation factor SII by Wind (2000)
10.1016/S0092-8674(02)00646-3 / Cell / The RNA polymerase II machinery by Woychik (2002)
10.1073/pnas.93.21.11552 / Proc. Natl. Acad. Sci. USA / In vitro characterization of mutant yeast RNA polymerase II with reduced binding for elongation factor TFIIS by Wu (1996)

Dates

Type	When
Created	21 years, 4 months ago (April 17, 2004, 2:47 p.m.)
Deposited	4 years, 2 months ago (June 15, 2021, 5:20 p.m.)
Indexed	4 days, 22 hours ago (Aug. 19, 2025, 6:27 a.m.)
Issued	22 years ago (Aug. 1, 2003)
Published	22 years ago (Aug. 1, 2003)
Published Print	22 years ago (Aug. 1, 2003)

Funders 0

None

BibTeX

@article{Kettenberger_2003, title={Architecture of the RNA Polymerase II-TFIIS Complex and Implications for mRNA Cleavage}, volume={114}, ISSN={0092-8674}, url={http://dx.doi.org/10.1016/s0092-8674(03)00598-1}, DOI={10.1016/s0092-8674(03)00598-1}, number={3}, journal={Cell}, publisher={Elsevier BV}, author={Kettenberger, Hubert and Armache, Karim-Jean and Cramer, Patrick}, year={2003}, month=aug, pages={347–357} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        19
      ]
    ],
    "date-time": "2025-08-19T10:27:29Z",
    "timestamp": 1755599249677
  },
  "reference-count": 63,
  "publisher": "Elsevier BV",
  "issue": "3",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2003,
            8,
            1
          ]
        ],
        "date-time": "2003-08-01T00:00:00Z",
        "timestamp": 1059696000000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2013,
            7,
            17
          ]
        ],
        "date-time": "2013-07-17T00:00:00Z",
        "timestamp": 1374019200000
      },
      "content-version": "vor",
      "delay-in-days": 3638,
      "URL": "https://www.elsevier.com/open-access/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2003,
        8
      ]
    ]
  },
  "DOI": "10.1016/s0092-8674(03)00598-1",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2004,
        4,
        17
      ]
    ],
    "date-time": "2004-04-17T18:47:25Z",
    "timestamp": 1082227645000
  },
  "page": "347-357",
  "source": "Crossref",
  "is-referenced-by-count": 289,
  "title": "Architecture of the RNA Polymerase II-TFIIS Complex and Implications for mRNA Cleavage",
  "prefix": "10.1016",
  "volume": "114",
  "author": [
    {
      "given": "Hubert",
      "family": "Kettenberger",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Karim-Jean",
      "family": "Armache",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Patrick",
      "family": "Cramer",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB1",
      "doi-asserted-by": "crossref",
      "first-page": "6964",
      "DOI": "10.1073/pnas.1030608100",
      "article-title": "Architecture of initiation-competent 12-subunit RNA polymerase II",
      "volume": "100",
      "author": "Armache",
      "year": "2003",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "14747",
      "DOI": "10.1074/jbc.272.23.14747",
      "article-title": "Transcription elongation through DNA arrest sites. A multistep process involving both RNA polymerase II subunit RPB9 and TFIIS",
      "volume": "272",
      "author": "Awrey",
      "year": "1997",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "22595",
      "DOI": "10.1074/jbc.273.35.22595",
      "article-title": "Yeast transcript elongation factor (TFIIS), structure and function. II",
      "volume": "273",
      "author": "Awrey",
      "year": "1998",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB4",
      "doi-asserted-by": "crossref",
      "first-page": "25",
      "DOI": "10.1002/j.1460-2075.1991.tb07917.x",
      "article-title": "Structural basis for the 3\u2032-5\u2032 exonuclease activity of Escherichia coli DNA polymerase I",
      "volume": "10",
      "author": "Beese",
      "year": "1991",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB5",
      "doi-asserted-by": "crossref",
      "first-page": "31266",
      "DOI": "10.1074/jbc.M002595200",
      "article-title": "Structure of a conserved domain common to the transcription factors TFIIS, elongin A, and CRSP70",
      "volume": "275",
      "author": "Booth",
      "year": "2000",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "905",
      "DOI": "10.1107/S0907444998003254",
      "article-title": "Crystallography & NMR system",
      "volume": "54",
      "author": "Brunger",
      "year": "1998",
      "journal-title": "Acta Crystallogr D"
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "788",
      "DOI": "10.1111/j.1432-1033.1995.tb20622.x",
      "article-title": "High-level biosynthetic substitution of methionine in proteins by its analogs 2-aminohexanoic acid, selenomethionine, telluromethionine and ethionine in Escherichia coli",
      "volume": "230",
      "author": "Budisa",
      "year": "1995",
      "journal-title": "Eur. J. Biochem."
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB8",
      "doi-asserted-by": "crossref",
      "first-page": "6969",
      "DOI": "10.1073/pnas.1130601100",
      "article-title": "Complete, 12-subunit RNA polymerase II at 4.1 \u00c5 resolution",
      "volume": "100",
      "author": "Bushnell",
      "year": "2003",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "1218",
      "DOI": "10.1073/pnas.251664698",
      "article-title": "Structural basis of transcription",
      "volume": "99",
      "author": "Bushnell",
      "year": "2002",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "493",
      "DOI": "10.1016/S0076-6879(97)77027-7",
      "article-title": "Ribbons",
      "volume": "277",
      "author": "Carson",
      "year": "1997",
      "journal-title": "Meth. Enzymol."
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB11",
      "doi-asserted-by": "crossref",
      "first-page": "3857",
      "DOI": "10.1101/gad.12.24.3857",
      "article-title": "The RNA cleavage activity of RNA polymerase III is mediated by an essential TFIIS-like subunit and is important for transcription termination",
      "volume": "12",
      "author": "Chedin",
      "year": "1998",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "8087",
      "DOI": "10.1073/pnas.91.17.8087",
      "article-title": "Cleavage of the nascent transcript induced by TFIIS is insufficient to promote read-through of intrinsic blocks to elongation by RNA polymerase II",
      "volume": "91",
      "author": "Cipres-Palacin",
      "year": "1994",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "89",
      "DOI": "10.1016/S0959-440X(02)00294-4",
      "article-title": "Multisubunit RNA polymerases",
      "volume": "12",
      "author": "Cramer",
      "year": "2002",
      "journal-title": "Curr Opin Struct Biol"
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "724",
      "DOI": "10.1002/bies.10127",
      "article-title": "Common structural features of nucleic acid polymerases",
      "volume": "24",
      "author": "Cramer",
      "year": "2002",
      "journal-title": "Bioessays"
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "640",
      "DOI": "10.1126/science.288.5466.640",
      "article-title": "Architecture of RNA polymerase II and implications for the transcription mechanism",
      "volume": "288",
      "author": "Cramer",
      "year": "2000",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "1863",
      "DOI": "10.1126/science.1059493",
      "article-title": "Structural basis of transcription",
      "volume": "292",
      "author": "Cramer",
      "year": "2001",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "5960",
      "DOI": "10.1128/MCB.20.16.5960-5973.2000",
      "article-title": "Genetic interactions between TFIIS and the Swi-Snf chromatin-remodeling complex",
      "volume": "20",
      "author": "Davie",
      "year": "2000",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "37456",
      "DOI": "10.1074/jbc.M207038200",
      "article-title": "The downstream DNA jaw of bacterial RNA polymerase facilitates both transcriptional initiation and pausing",
      "volume": "277",
      "author": "Ederth",
      "year": "2002",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "224",
      "DOI": "10.1016/S0167-4781(02)00454-2",
      "article-title": "The many conformational states of RNA polymerase elongation complexes and their roles in the regulation of transcription",
      "volume": "1577",
      "author": "Erie",
      "year": "2002",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "287",
      "DOI": "10.1016/S0167-4781(02)00459-1",
      "article-title": "Promoting elongation with transcript cleavage stimulatory factors",
      "volume": "1577",
      "author": "Fish",
      "year": "2002",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB21",
      "doi-asserted-by": "crossref",
      "first-page": "1876",
      "DOI": "10.1126/science.1059495",
      "article-title": "Structural basis of transcription",
      "volume": "292",
      "author": "Gnatt",
      "year": "2001",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "30441",
      "DOI": "10.1074/jbc.270.51.30441",
      "article-title": "Variation in the size of nascent RNA cleavage products as a function of transcript length and elongation competence",
      "volume": "270",
      "author": "Gu",
      "year": "1995",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "12393",
      "DOI": "10.1074/jbc.275.17.12393",
      "article-title": "Transcription factor S, a cleavage induction factor of the archaeal RNA polymerase",
      "volume": "275",
      "author": "Hausner",
      "year": "2000",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "35506",
      "DOI": "10.1074/jbc.M004721200",
      "article-title": "RNA polymerase II subunit rpb9 regulates transcription elongation in vivo",
      "volume": "275",
      "author": "Hemming",
      "year": "2000",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "608",
      "DOI": "10.1016/S0021-9258(17)43705-7",
      "article-title": "Analysis of the stimulatory factor of RNA polymerase II in the initiation and elongation complex",
      "volume": "259",
      "author": "Horikoshi",
      "year": "1984",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB26",
      "doi-asserted-by": "crossref",
      "first-page": "1342",
      "DOI": "10.1101/gad.6.7.1342",
      "article-title": "The RNA polymerase II ternary complex cleaves the nascent transcript in a 3\u2032-5\u2032 direction in the presence of elongation factor SII",
      "volume": "6",
      "author": "Izban",
      "year": "1992",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB27",
      "doi-asserted-by": "crossref",
      "first-page": "12874",
      "DOI": "10.1016/S0021-9258(18)31468-6",
      "article-title": "The increment of SII-facilitated transcript cleavage varies dramatically between elongation competent and incompletent RNA polymerase II ternary complexes",
      "volume": "268",
      "author": "Izban",
      "year": "1993",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "12864",
      "DOI": "10.1016/S0021-9258(18)31467-4",
      "article-title": "SII-facilitated transcript cleavage in RNA polymerase II complexes stalled early after initiation occurs in primarily dinucleotide increments",
      "volume": "268",
      "author": "Izban",
      "year": "1993",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "13677",
      "DOI": "10.1073/pnas.93.24.13677",
      "article-title": "Fidelity of RNA polymerase II transcription controlled by elongation factor TFIIS",
      "volume": "93",
      "author": "Jeon",
      "year": "1996",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "9106",
      "DOI": "10.1073/pnas.91.19.9106",
      "article-title": "The transcription factor TFIIS zinc ribbon dipeptide Asp-Glu is critical for stimulation of elongation and RNA cleavage by RNA polymerase II",
      "volume": "91",
      "author": "Jeon",
      "year": "1994",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "217",
      "DOI": "10.1016/0092-8674(94)90314-X",
      "article-title": "Complexes of yeast RNA polymerase II and RNA are substrates for TFIIS-induced RNA cleavage",
      "volume": "77",
      "author": "Johnson",
      "year": "1994",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "110",
      "DOI": "10.1107/S0108767390010224",
      "article-title": "Improved methods for building protein models in electron density maps and the location of errors in these models",
      "volume": "A47",
      "author": "Jones",
      "year": "1991",
      "journal-title": "Acta Crystallogr."
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "777",
      "DOI": "10.1146/annurev.bi.63.070194.004021",
      "article-title": "Function and structure relationships in DNA polymerases",
      "volume": "63",
      "author": "Joyce",
      "year": "1994",
      "journal-title": "Annu. Rev. Biochem."
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "619",
      "DOI": "10.1126/science.289.5479.619",
      "article-title": "A structural model of transcription elongation",
      "volume": "289",
      "author": "Korzheva",
      "year": "2000",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "7201",
      "DOI": "10.1074/jbc.272.11.7201",
      "article-title": "Domain organization of Escherichia coli transcript cleavage factors GreA and GreB",
      "volume": "272",
      "author": "Koulich",
      "year": "1997",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB36",
      "doi-asserted-by": "crossref",
      "first-page": "3221",
      "DOI": "10.1073/pnas.93.8.3221",
      "article-title": "Protein-RNA interactions in the active center of transcription elongation complex",
      "volume": "93",
      "author": "Markovtsov",
      "year": "1996",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB37",
      "doi-asserted-by": "crossref",
      "first-page": "10604",
      "DOI": "10.1073/pnas.93.20.10604",
      "article-title": "Elongation factor TFIIS contains three structural domains",
      "volume": "93",
      "author": "Morin",
      "year": "1996",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB38",
      "doi-asserted-by": "crossref",
      "first-page": "157",
      "DOI": "10.1107/S0108767393007597",
      "article-title": "AMoRe",
      "volume": "A50",
      "author": "Navaza",
      "year": "1994",
      "journal-title": "Acta Crystallogr."
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB39",
      "doi-asserted-by": "crossref",
      "first-page": "18303",
      "DOI": "10.1074/jbc.M301103200",
      "article-title": "NTP-driven translocation by human RNA polymerase II",
      "volume": "278",
      "author": "Nedialkov",
      "year": "2003",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "38",
      "DOI": "10.1016/S0092-8674(00)80180-4",
      "article-title": "The RNA-DNA hybrid maintains the register of transcription by preventing backtracking of RNA polymerase",
      "volume": "89",
      "author": "Nudler",
      "year": "1997",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB41",
      "doi-asserted-by": "crossref",
      "first-page": "22589",
      "DOI": "10.1074/jbc.273.35.22589",
      "article-title": "Yeast transcript elongation factor TFIIS, structure and function. I",
      "volume": "273",
      "author": "Olmsted",
      "year": "1998",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB42",
      "doi-asserted-by": "crossref",
      "first-page": "335",
      "DOI": "10.1016/S0092-8674(03)00600-7",
      "article-title": "Structure and function of the transcription elongation factor GreB bound to bacterial RNA polymerase",
      "volume": "114",
      "author": "Opalka",
      "year": "2003",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB43",
      "doi-asserted-by": "crossref",
      "first-page": "265",
      "DOI": "10.1006/jmbi.2001.4842",
      "article-title": "Roles of RNA:DNA hybrid stability, RNA structure, and active site conformation in pausing by human RNA polymerase II",
      "volume": "311",
      "author": "Palangat",
      "year": "2001",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB44",
      "doi-asserted-by": "crossref",
      "first-page": "799",
      "DOI": "10.1016/S1097-2765(02)00502-6",
      "article-title": "Exchange of RNA polymerase II initiation and elongation factors during gene expression in vivo",
      "volume": "9",
      "author": "Pokholok",
      "year": "2002",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB45",
      "doi-asserted-by": "crossref",
      "first-page": "22301",
      "DOI": "10.1074/jbc.271.37.22301",
      "article-title": "Elongation factor SII contacts the 3\u2032-end of RNA in the RNA polymerase II elongation complex",
      "volume": "271",
      "author": "Powell",
      "year": "1996",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB46",
      "doi-asserted-by": "crossref",
      "first-page": "9944",
      "DOI": "10.1021/bi00089a010",
      "article-title": "Novel zinc finger motif in the basal transcriptional machinery",
      "volume": "32",
      "author": "Qian",
      "year": "1993",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB47",
      "doi-asserted-by": "crossref",
      "first-page": "3795",
      "DOI": "10.1016/S0021-9258(19)50596-8",
      "article-title": "Elongation factor-dependent transcript shortening by template-engaged RNA polymerase II",
      "volume": "267",
      "author": "Reines",
      "year": "1992",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB48",
      "doi-asserted-by": "crossref",
      "first-page": "21549",
      "DOI": "10.1074/jbc.271.35.21549",
      "article-title": "Amanitin greatly reduces the rate of transcription by RNA polymerase II ternary complexes but fails to inhibit some transcript cleavage modes",
      "volume": "271",
      "author": "Rudd",
      "year": "1996",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB49",
      "doi-asserted-by": "crossref",
      "first-page": "8057",
      "DOI": "10.1073/pnas.91.17.8057",
      "article-title": "The active site of RNA polymerase II participates in transcript cleavage within arrested ternary complexes",
      "volume": "91",
      "author": "Rudd",
      "year": "1994",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB50",
      "doi-asserted-by": "crossref",
      "first-page": "333",
      "DOI": "10.1126/science.277.5324.333",
      "article-title": "The Ras-RasGAP complex",
      "volume": "277",
      "author": "Scheffzek",
      "year": "1997",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB51",
      "doi-asserted-by": "crossref",
      "first-page": "5064",
      "DOI": "10.1021/bi00668a018",
      "article-title": "Purification of a factor from Ehrlich ascites tumor cells specifically stimulating RNA polymerase II",
      "volume": "15",
      "author": "Sekimizu",
      "year": "1976",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB52",
      "doi-asserted-by": "crossref",
      "first-page": "24420",
      "DOI": "10.1074/jbc.M202059200",
      "article-title": "Use of an in vivo reporter assay to test for transcriptional and translational fidelity in yeast",
      "volume": "277",
      "author": "Shaw",
      "year": "2002",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB53",
      "doi-asserted-by": "crossref",
      "first-page": "693",
      "DOI": "10.1146/annurev.biochem.72.121801.161551",
      "article-title": "The RNA polymerase II elongation complex",
      "volume": "72",
      "author": "Shilatifard",
      "year": "2003",
      "journal-title": "Annu. Rev. Biochem."
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB54",
      "doi-asserted-by": "crossref",
      "first-page": "36541",
      "DOI": "10.1074/jbc.M005834200",
      "article-title": "Structural basis for the species-specific activity of TFIIS",
      "volume": "275",
      "author": "Shimasaki",
      "year": "2000",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB55",
      "doi-asserted-by": "crossref",
      "first-page": "2234",
      "DOI": "10.1093/emboj/cdg193",
      "article-title": "Unified two-metal mechanism of RNA synthesis and degradation by RNA polymerase",
      "volume": "22",
      "author": "Sosunov",
      "year": "2003",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB56",
      "doi-asserted-by": "crossref",
      "first-page": "636",
      "DOI": "10.1038/373636a0",
      "article-title": "Crystal structure of the GreA transcript cleavage factor from Escherichia coli",
      "volume": "373",
      "author": "Stebbins",
      "year": "1995",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB57",
      "doi-asserted-by": "crossref",
      "first-page": "627",
      "DOI": "10.1016/S0092-8674(00)81191-5",
      "article-title": "Transcriptional fidelity and proofreading by RNA polymerase II",
      "volume": "93",
      "author": "Thomas",
      "year": "1998",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB58",
      "doi-asserted-by": "crossref",
      "first-page": "712",
      "DOI": "10.1038/nature752",
      "article-title": "Crystal structure of a bacterial RNA polymerase holoenzyme at 2.6 A resolution",
      "volume": "417",
      "author": "Vassylyev",
      "year": "2002",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB59",
      "doi-asserted-by": "crossref",
      "first-page": "843",
      "DOI": "10.1073/pnas.90.3.843",
      "article-title": "Identification of a 3\u2032-5\u2032 exonuclease activity associated with human RNA polymerase II",
      "volume": "90",
      "author": "Wang",
      "year": "1993",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB60",
      "doi-asserted-by": "crossref",
      "first-page": "24189",
      "DOI": "10.1074/jbc.M211197200",
      "article-title": "Intrinsic transcript cleavage in yeast RNA polymerase II elongation complexes",
      "volume": "26",
      "author": "Weilbaecher",
      "year": "2003",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB61",
      "doi-asserted-by": "crossref",
      "first-page": "327",
      "DOI": "10.1002/(SICI)1521-1878(200004)22:4<327::AID-BIES3>3.0.CO;2-4",
      "article-title": "Transcription elongation factor SII",
      "volume": "22",
      "author": "Wind",
      "year": "2000",
      "journal-title": "Bioessays"
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB62",
      "doi-asserted-by": "crossref",
      "first-page": "453",
      "DOI": "10.1016/S0092-8674(02)00646-3",
      "article-title": "The RNA polymerase II machinery",
      "volume": "108",
      "author": "Woychik",
      "year": "2002",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(03)00598-1_BIB63",
      "doi-asserted-by": "crossref",
      "first-page": "11552",
      "DOI": "10.1073/pnas.93.21.11552",
      "article-title": "In vitro characterization of mutant yeast RNA polymerase II with reduced binding for elongation factor TFIIS",
      "volume": "93",
      "author": "Wu",
      "year": "1996",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    }
  ],
  "container-title": "Cell",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0092867403005981?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0092867403005981?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        6,
        15
      ]
    ],
    "date-time": "2021-06-15T21:20:08Z",
    "timestamp": 1623792008000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0092867403005981"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2003,
        8
      ]
    ]
  },
  "references-count": 63,
  "journal-issue": {
    "issue": "3",
    "published-print": {
      "date-parts": [
        [
          2003,
          8
        ]
      ]
    }
  },
  "alternative-id": [
    "S0092867403005981"
  ],
  "URL": "http://dx.doi.org/10.1016/S0092-8674(03)00598-1",
  "relation": {
    "has-review": [
      {
        "id-type": "doi",
        "id": "10.3410/f.1014907.198501",
        "asserted-by": "object"
      },
      {
        "id-type": "doi",
        "id": "10.3410/f.1014907.195516",
        "asserted-by": "object"
      },
      {
        "id-type": "doi",
        "id": "10.3410/f.1014907.199210",
        "asserted-by": "object"
      },
      {
        "id-type": "doi",
        "id": "10.3410/f.1014907.195166",
        "asserted-by": "object"
      }
    ]
  },
  "ISSN": [
    "0092-8674"
  ],
  "subject": [],
  "container-title-short": "Cell",
  "published": {
    "date-parts": [
      [
        2003,
        8
      ]
    ]
  }
}