Crossref
journal-article
Elsevier BV
Cell (78)
References
140
Referenced
4,818
10.1074/jbc.272.44.27678
/ J. Biol. Chem. / TβRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling by Abdollah (1997)10.1038/ncb826
/ Nat. Cell Biol. / Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-β by Abreu (2002)10.1016/S0955-0674(99)00081-2
/ Curr. Opin. Cell Biol. / Smads as transcriptional co-modulators by Attisano (2000)10.1038/ncb753
/ Nat. Cell Biol. / SMIF, a Smad4-interacting protein that functions as a co-activator in TGFβ signalling by Bai (2002)10.1006/dbio.2002.0779
/ Dev. Biol. / Extracellular regulation of BMP signaling in vertebrates by Balemans (2002)10.1091/mbc.12.1.27
/ Mol. Biol. Cell / Transforming growth factor-β1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism by Bhowmick (2001)10.1101/gad.14.2.187
/ Genes Dev. / A mechanism of suppression of TGF-β/SMAD signaling by NF-kappa B/RelA by Bitzer (2000)10.1016/S0969-2126(02)00780-3
/ Structure / The 1.1 Å crystal structure of human TGF-β type II receptor ligand binding domain by Boesen (2002)10.1038/35078562
/ Nat. Cell Biol. / TGF-β induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation by Bonni (2001)10.1126/science.283.5410.2080
/ Science / Requirement of type III TGF-β receptor for endocardial cell transformation in the heart by Brown (1999)10.1074/jbc.274.13.8797
/ J. Biol. Chem. / MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cells by Brown (1999)10.1126/science.280.5368.1455
/ Science / Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton by Brunet (1998)10.1038/84995
/ Nat. Struct. Biol. / The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerization by Chacko (2001){'key': '10.1016/S0092-8674(03)00432-X_BIB14', 'article-title': 'Features of a Smad3 MH1-DNA complex', 'volume': 'in press', 'author': 'Chai', 'year': '2003', 'journal-title': 'J. Biol. Chem.'}
/ J. Biol. Chem. / Features of a Smad3 MH1-DNA complex by Chai (2003)10.1016/S0092-8674(02)00801-2
/ Cell / E2F4/5 and p107 as Smad cofactors linking the TGFβ receptor to c-myc repression by Chen (2002)10.1101/gad.12.14.2144
/ Genes Dev. / Determinants of specificity in the TGF-β signal transduction by Chen (1998)10.1101/gad.1041203
/ Genes Dev. / EGF-CFC proteins are essential coreceptors for the TGF-β signals Vg1 and GDF1 by Cheng (2003)10.1016/S0959-440X(97)80015-2
/ Curr. Opin. Struct. Biol. / Physical basis of a protein-DNA recognition code by Choo (1997)10.1128/MCB.20.9.3157-3167.2000
/ Mol. Cell. Biol. / STRAP and Smad7 synergize in the inhibition of transforming growth factor β signaling by Datta (2000)10.1186/rr57
/ Respir. Res. / Bone morphogenetic proteins, genetics and the pathophysiology of primary pulmonary hypertension by De Caestecker (2001)10.1073/pnas.090099297
/ Proc. Natl. Acad. Sci. USA / Transforming growth factor β-inducible independent binding of SMAD to the Smad7 promoter by Denissova (2000)10.1093/emboj/17.11.3091
/ EMBO J. / Direct binding of Smad3 and Smad4 to critical TGFβ-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene by Dennler (1998)10.1016/S0092-8674(00)81335-5
/ Cell / Nomenclature by Derynck (1996)10.1016/S0092-8674(00)81696-7
/ Cell / Smads by Derynck (1998)10.1038/ncb975
/ Nat. Cell Biol. / Distinct endocytic pathways regulate TGFβ receptor signaling and turnover by Di Guglielmo (2003)10.1074/jbc.C100008200
/ J. Biol. Chem. / Smurf1 interacts with transforming growth factor-β type I receptor through Smad7 and induces receptor degradation by Ebisawa (2001)10.1093/emboj/16.13.3912
/ EMBO J. / A kinase subdomain of transforming growth factor-β (TGF-β) type I receptor determines the TGF-β intracellular signaling specificity by Feng (1997)10.1093/emboj/19.19.5178
/ EMBO J. / Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-β by Feng (2000)10.1091/mbc.12.5.1431
/ Mol. Biol. Cell / Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins by Fukuchi (2001)10.1128/MCB.21.15.5132-5141.2001
/ Mol. Cell. Biol. / Axin facilitates Smad3 activation in the transforming growth factor β signaling pathway by Furuhashi (2001)10.1038/6821
/ Nat. Genet. / Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis by Gong (1999)10.1146/annurev.cellbio.15.1.607
/ Annu. Rev. Cell Dev. Biol. / Transport between the cell nucleus and the cytoplasm by Gorlich (1999)10.1093/emboj/21.7.1743
/ EMBO J. / Balancing the activation state of the endothelium via two distinct TGF-β type I receptors by Goumans (2002)10.1074/jbc.275.5.3206
/ J. Biol. Chem. / Identification of a binding site on the type II activin receptor for activin and inhibin by Gray (2000)10.1038/4887
/ Nat. Struct. Biol. / Three-finger toxin fold for the extracellular ligand-binding domain of the type II activin receptor serine kinase by Greenwald (1999)10.1016/S1097-2765(03)00094-7
/ Mol. Cell / The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly by Greenwald (2003)10.1038/ncb812
/ Nat. Cell Biol. / Nuclear exclusion of Smad2 is a mechanism leading to loss of competence by Grimm (2002)10.1006/jmbi.2000.4486
/ J. Mol. Biol. / MH1 domain of Smad is a degraded homing endonuclease by Grishin (2001)10.1016/S1097-2765(02)00639-1
/ Mol. Cell / Control of Smad7 stability by competition between acetylation and ubiquitination by Gronroos (2002)10.1038/nature01245
/ Nature / Structural basis of BMP signalling inhibition by the cystine knot protein Noggin by Groppe (2002)10.1038/35068657
/ Nature / Developmental biology. A twist on embryonic signalling by Harland (2001){'key': '10.1016/S0092-8674(03)00432-X_BIB42', 'first-page': '203', 'article-title': 'Crystal structure of the human TβR2 ectodomain-TGF-β3 complex', 'volume': '9', 'author': 'Hart', 'year': '2002', 'journal-title': 'Nat. Struct. Biol.'}
/ Nat. Struct. Biol. / Crystal structure of the human TβR2 ectodomain-TGF-β3 complex by Hart (2002)10.1101/gad.12.2.186
/ Genes Dev. / Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumour suppressor by Hata (1998)10.1083/jcb.200204088
/ J. Cell Biol. / TGF-β receptor internalization into EEA1-enriched early endosomes by Hayes (2002)10.1093/emboj/20.11.2789
/ EMBO J. / The adaptor molecule Disabled-2 links the transforming growth factor β receptors to the Smad pathway by Hocevar (2001)10.1006/dbio.1998.9168
/ Dev. Biol. / Dominant-negative Smad2 mutants inhibit activin/Vg1 signaling and disrupt axis formation in Xenopus by Hoodless (1999)10.1016/S0092-8674(00)80555-3
/ Cell / Crystal structure of the cytoplasmic domain of the type I TGF-β receptor in complex with FKBP12 by Huse (1999)10.1016/S1097-2765(01)00332-X
/ Mol. Cell / The TGF-β receptor activation process by Huse (2001)10.1074/jbc.M208532200
/ J. Biol. Chem. / Stoichiometry of active Smad-transcription factor complexes on DNA by Inman (2002)10.1016/S1097-2765(02)00585-3
/ Mol. Cell / Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-β receptor activity by Inman (2002)10.1074/jbc.275.9.6075
/ J. Biol. Chem. / Smad6 is a Smad1/5-induced smad inhibitor. Characterization of bone morphogenetic protein-responsive element in the mouse Smad6 promoter by Ishida (2000)10.1093/emboj/20.15.4132
/ EMBO J. / Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads by Itoh (2001)10.1074/jbc.273.44.29195
/ J. Biol. Chem. / Transforming growth factor β1 induces nuclear export of inhibitory Smad7 by Itoh (1998)10.1074/jbc.M208258200
/ J. Biol. Chem. / Elucidation of Smad requirement in transforming growth factor-β type I receptor-induced responses by Itoh (2003)10.1074/jbc.M005799200
/ J. Biol. Chem. / Distinct oligomeric states of SMAD proteins in the TGF-β pathway by Jayaraman (2000)10.1074/jbc.274.29.20709
/ J. Biol. Chem. / Interaction of Smad complexes with tripartite DNA-binding sites by Johnson (1999)10.1016/S1097-2765(03)00109-6
/ Mol. Cell / A self-enabling TGFβ response coupled to stress signaling by Kang (2003)10.1038/nature00969
/ Nature / A component of the ARC/Mediator complex required for TGFβ/Nodal signalling by Kato (2002)10.1016/S1097-2765(00)00134-9
/ Mol. Cell / Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF-β receptor for degradation by Kavsak (2000)10.1093/emboj/17.14.4056
/ EMBO J. / Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors by Kawabata (1998)10.1038/40906
/ Nature / Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic by Kim (1997)10.1038/75903
/ Nat. Struct. Biol. / Crystal structure of the BMP-2-BRIA ectodomain complex by Kirsch (2000)10.1107/S0021889891004399
/ J. Appl. Crystallogr. / Molscript by Kraulis (1991)10.1101/gad.11.8.984
/ Genes Dev. / The TGF-β family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase by Kretzschmar (1997)10.1101/gad.13.7.804
/ Genes Dev. / A mechanism of repression of TGF-β/Smad signaling by oncogenic Ras by Kretzschmar (1999)10.1091/mbc.12.4.1079
/ Mol. Biol. Cell / Transforming growth factor-β induces nuclear import of Smad3 in an importin-β1 and Ran-dependent manner by Kurisaki (2001)10.1016/S1097-2765(00)80119-7
/ Mol. Cell / Smad2 and Smad3 positively and negatively regulate TGF-β-dependent transcription through the forkhead DNA-binding protein FAST2 by Labbe (1998)10.1038/35057062
/ Nature / Initial sequencing and analysis of the human genome by Lander (2001)10.1038/35006129
/ Nature / Betaglycan binds inhibin and can mediate functional antagonism of activin signalling by Lewis (2000)10.1016/S0896-6273(00)00148-3
/ Neuron / Noggin antagonizes BMP signaling to create a niche for adult neurogenesis by Lim (2000)10.1074/jbc.C000580200
/ J. Biol. Chem. / Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in TGF-β signaling by Lin (2000)10.1101/gad.11.23.3157
/ Genes Dev. / Dual role of the Smad4/DPC4 tumor suppressor in TGF-β-inducible transcriptional complexes by Liu (1997)10.1016/S1359-6101(00)00031-9
/ Cytokine Growth Factor Rev. / Ski/Sno and TGF-β signaling by Liu (2001)10.1038/70258
/ Nat. Cell Biol. / Ubiquitin-dependent degradation of TGF-β-activated Smad2 by Lo (1999)10.1093/emboj/17.4.996
/ EMBO J. / The L3 loop by Lo (1998)10.1093/emboj/20.1.128
/ EMBO J. / Epidermal growth factor signaling via Ras controls the Smad transcriptional co-repressor TGIF by Lo (2001)10.1074/jbc.M203495200
/ J. Biol. Chem. / Transforming growth factor β activates Smad2 in the absence of receptor endocytosis by Lu (2002)10.1101/gad.13.17.2196
/ Genes Dev. / The Ski oncoprotein interacts with the Smad proteins to repress TGF-β signaling by Luo (1999)10.1016/S0092-8674(00)81817-6
/ Cell / MADR2 is a substrate of the TGF-β receptor and its phosphorylation is required for nuclear accumulation and signalling by Macias-Silva (1996)10.1126/science.1075762
/ Science / The protein kinase complement of the human genome by Manning (2002)10.1097/00062752-199809000-00005
/ Curr. Opin. Hematol. / Genetic abnormalities in hereditary hemorrhagic telangiectasia by Marchuk (1998)10.1016/S0022-2836(03)00023-8
/ J. Mol. Biol. / Solution structure of the chick TGF-β type II receptor ligand-binding domain by Marlow (2003)10.1146/annurev.biochem.67.1.753
/ Annu. Rev. Biochem. / TGF-β signal transduction by Massagué (1998)10.1038/35043051
/ Nat. Rev. Mol. Cell Biol. / How cells read TGF-β signals by Massagué (2000)10.1101/gad.14.6.627
/ Genes Dev. / Controlling TGF-β signaling by Massagué (2000)10.1093/emboj/19.8.1745
/ EMBO J. / Transcriptional control by the TGF-β/Smad signaling system by Massagué (2000)10.1016/S0092-8674(00)00121-5
/ Cell / TGF-β Signaling in growth control, cancer, and heritable disorders by Massagué (2000)10.1146/annurev.biochem.67.1.265
/ Annu. Rev. Biochem. / Nucleocytoplasmic transport by Mattaj (1998)10.1128/MCB.20.24.9346-9355.2000
/ Mol. Cell. Biol. / Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA by Mirura (2000)10.1002/pro.5560050705
/ Protein Sci. / The crystal structure of TGF-beta 3 and comparison to TGF-β2 by Mittl (1996)10.1091/mbc.e02-02-0063
/ Mol. Biol. Cell / Functional heterogeneity of bone morphogenetic protein receptor-II mutants found in patients with primary pulmonary hypertension by Nishihara (2002)10.1038/46794
/ Nature / Silencing of TGF-β signalling by the pseudoreceptor BAMBI by Onichtchouk (1999)10.1016/S0168-9525(99)01916-2
/ Trends Genet. / TGF-β-related pathways. Roles in Caenorhabditis elegans development by Patterson (2000)10.1101/gad.854200
/ Genes Dev. / TGF-β inhibits p70 S6 kinase via protein phosphatase 2A to induce G1 arrest by Petritsch (2000)10.1128/MCB.20.23.9041-9054.2000
/ Mol. Biol. Cell / Transforming growth factor β-independent shuttling of Smad4 between the cytoplasm and nucleus by Pierreux (2000)10.1016/S1097-2765(01)00417-8
/ Mol. Cell / Structural basis of Smad1 activation by receptor kinase phosphorylation by Qin (2001)10.1093/emboj/21.1.145
/ EMBO J. / Different Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline-rich motif by Randall (2002)-
Rosa, F.M. (2002). Cripto, a multifunctional partner in signaling: molecular forms and activities. Sci. STKE (158), pe47.
(
10.1126/scisignal.1582002pe47
) 10.1074/jbc.M100069200
/ J. Biol. Chem. / Oncogenic ras represses transforming growth factor-β/Smad signaling by degrading tumor suppressor Smad4 by Saha (2001)10.1093/genetics/139.3.1347
/ Genetics / Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster by Sekelsky (1995)10.1038/35070086
/ Nat. Cell Biol. / TGF-β influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b by Seoane (2001)10.1016/S0168-9525(00)02006-0
/ Trends Genet. / The EGF-CFC gene family in vertebrate development by Shen (2000)10.1002/1521-1878(200103)23:3<223::AID-BIES1032>3.0.CO;2-U
/ Bioessays / Structural insights on Smad function in TGF-β signaling by Shi (2001)10.1016/S0092-8674(00)81600-1
/ Cell / Crystal structure of a Smad MH1 domain bound to DNA by Shi (1998)10.1074/jbc.272.44.28107
/ J. Biol. Chem. / Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling by Souchelnytskyi (1997)10.1038/35070076
/ Nat. Cell Biol. / Repression of p15INK4b expression by Myc through association with Miz-1 by Staller (2001)10.1126/science.286.5440.771
/ Science / Negative feedback regulation of TGF-β signaling by the SnoN oncoprotein by Stroschein (1999)10.1101/gad.912901
/ Genes Dev. / Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN by Stroschein (2001)10.1146/annurev.bb.24.060195.001413
/ Annu. Rev. Biophys. Biomol. Struct. / The cysteine-knot growth-factor superfamily by Sun (1995)10.1074/jbc.M201901200
/ J. Biol. Chem. / Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane by Suzuki (2002)10.1074/jbc.M212663200
/ J. Biol. Chem. / Chromosomal region maitenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-β signaling by Smad7 by Tajima (2003)10.1126/science.1075994
/ Science / Disruption of transforming growth factor-β signaling in ELF β-spectrin–deficient mice by Tang (2003)10.1016/S0968-0004(99)01519-4
/ Trends Biochem. Sci. / Signaling inputs converge on nuclear effectors in TGF-β signaling by ten Dijke (2000)10.1002/jcp.10066
/ J. Cell. Physiol. / Regulation of Cell Proliferation by Smad Proteins by ten Dijke (2002)10.1093/emboj/cdg156
/ EMBO J. / Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-β ligand:receptor interactions by Thompson (2003)10.1016/S0092-8674(00)81701-8
/ Cell / SARA, a FYVE Domain Protein that Recruits Smad2 to the TGF-β Receptor by Tsukazaki (1998)10.1038/17826
/ Nature / Inhibition of transforming growth factor-β/SMAD signalling by the interferon-gamma/STAT pathway by Ulloa (1999)10.1016/S1097-2765(01)00382-3
/ Mol. Cell / The anaphase-promoting complex mediates TGF-β signaling by targeting SnoN for destruction by Wan (2001)10.1073/pnas.97.26.14394
/ Proc. Natl. Acad. Sci. USA / Ski represses bone morphogenetic protein signaling in Xenopus and mammalian cells by Wang (2000)10.1093/embo-reports/kvd029
/ EMBO Rep. / Regulation of intracellular dynamics of Smad4 by its leucine-rich nuclear export signal by Watanabe (2000)10.1128/MCB.20.21.8103-8111.2000
/ Mol. Cell. Biol. / Inactivation of smad-transforming growth factor beta signaling by Ca(2+)-calmodulin-dependent protein kinase II by Wicks (2000)10.1016/S0092-8674(00)80712-6
/ Cell / A Smad transcriptional corepressor by Wotton (1999)10.1074/jbc.274.52.37105
/ J. Biol. Chem. / Multiple modes of repression by the Smad transcriptional corepressor TGIF by Wotton (1999){'key': '10.1016/S0092-8674(03)00432-X_BIB124', 'first-page': '457', 'article-title': 'The Smad transcriptional corepressor TGIF recruits mSin3', 'volume': '12', 'author': 'Wotton', 'year': '2001', 'journal-title': 'Cell Growth Differ.'}
/ Cell Growth Differ. / The Smad transcriptional corepressor TGIF recruits mSin3 by Wotton (2001)10.1126/science.287.5450.92
/ Science / Structural basis of Smad2 recognition by the Smad anchor for receptor activation by Wu (2000)10.1074/jbc.M100174200
/ J. Biol. Chem. / Formation of a stable heterodimer between Smad2 and Smad4 by Wu (2001)10.1016/S1097-2765(01)00421-X
/ Mol. Cell / Crystal structure of a phosphorylated Smad2 by Wu (2001)10.1016/S0092-8674(02)01006-1
/ Cell / Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski by Wu (2002)10.1073/pnas.97.14.7853
/ Proc. Natl. Acad. Sci. USA / A distinct nuclear localization signal in the N terminus of Smad3 determines its ligand-induced nuclear translocation by Xiao (2000)10.1074/jbc.C000345200
/ J. Biol. Chem. / Importin β mediates nuclear translocation of Smad3 by Xiao (2000)10.1074/jbc.M103117200
/ J. Biol. Chem. / Nucleocytoplasmic shuttling of Smad1 conferred by its nuclear localization and nuclear export signal by Xiao (2001)10.1038/sj.onc.1206212
/ Oncogene / An extended bipartite nuclear localization signal in Smad4 is required for its nuclear import and transcriptional activity by Xiao (2003)10.1038/35019649
/ Nat. Cell Biol. / Smad2 nuclear import function masked by SARA and unmasked by TGFβ-dependent phosphorylation by Xu (2000)10.1016/S1097-2765(02)00586-5
/ Mol. Cell / Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGF-β signaling complexes in the cytoplasm and nucleus by Xu (2002)10.1074/jbc.274.2.703
/ J. Biol. Chem. / Alternatively spliced variant of Smad2 lacking exon 3 by Yagi (1999)10.1128/MCB.17.12.7019
/ Mol. Cell. Biol. / Tumor suppressor Smad4 is a transforming growth factor β-inducible DNA binding protein by Yingling (1997)10.1093/emboj/cdf366
/ EMBO J. / TGF-β receptor-activated p38 MAP kinase mediates Smad-independent TGF-β responses by Yu (2002)10.1016/S1097-2765(00)80061-1
/ Mol. Cell / Human Smad3 and Smad4 are sequence-specific transcription activators by Zawel (1998)10.1073/pnas.98.3.974
/ Proc. Natl. Acad. Sci. USA / Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase by Zhang (2001)10.1038/23293
/ Nature / A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation by Zhu (1999)
Dates
Type | When |
---|---|
Created | 21 years, 4 months ago (April 17, 2004, 2:47 p.m.) |
Deposited | 2 years, 6 months ago (Jan. 25, 2023, 6:02 p.m.) |
Indexed | 9 hours, 36 minutes ago (Aug. 23, 2025, 1 a.m.) |
Issued | 22 years, 2 months ago (June 1, 2003) |
Published | 22 years, 2 months ago (June 1, 2003) |
Published Print | 22 years, 2 months ago (June 1, 2003) |
@article{Shi_2003, title={Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus}, volume={113}, ISSN={0092-8674}, url={http://dx.doi.org/10.1016/s0092-8674(03)00432-x}, DOI={10.1016/s0092-8674(03)00432-x}, number={6}, journal={Cell}, publisher={Elsevier BV}, author={Shi, Yigong and Massagué, Joan}, year={2003}, month=jun, pages={685–700} }