DOI: 10.1016/s0092-8674(03)00351-9. Structure and Biogenesis of the Capsular F1 Antigen from Yersinia pestis

Structure and Biogenesis of the Capsular F1 Antigen from Yersinia pestis

10.1016/s0092-8674(03)00351-9

Crossref journal-article

Elsevier BV

Cell (78)

Bibliography

Zavialov, A. V., Berglund, J., Pudney, A. F., Fooks, L. J., Ibrahim, T. M., MacIntyre, S., & Knight, S. D. (2003). Structure and Biogenesis of the Capsular F1 Antigen from Yersinia pestis. Cell, 113(5), 587â596.

Authors 7

Anton V Zavialov (first)
Jenny Berglund (additional)
Alexander F Pudney (additional)
Laura J Fooks (additional)
Tara M Ibrahim (additional)
Sheila MacIntyre (additional)
Stefan D Knight (additional)

References 33 Referenced 219

10.1107/S0907444998003254 / Acta Crystallogr. D / Crystallography & NMR system by Brünger (1998)
{'key': '10.1016/S0092-8674(03)00351-9_BIB2', 'first-page': '760', 'article-title': 'The CCP4 (Collaborative Computational Project 4) suite', 'volume': '50', 'author': 'CCP4', 'year': '1994', 'journal-title': 'Acta Crystallogr. D. Biol. Crystallogr.'} / Acta Crystallogr. D. Biol. Crystallogr. / The CCP4 (Collaborative Computational Project 4) suite by CCP4 (1994)
10.1128/JB.181.8.2422-2429.1999 / J. Bacteriol. / Structural and functional significance of the FGL sequence of the periplasmic chaperone Caf1M of Yersinia pestis by Chapman (1999)
10.1126/science.285.5430.1061 / Science / X-ray structure of the FimC-FimH chaperone-adhesin complex from uropathogenic Escherichia coli by Choudhury (1999)
10.1128/IAI.70.3.1453-1460.2002 / Infect. Immun. / Role of fraction 1 antigen of Yersinia pestis in inhibition of phagocytosis by Du (2002)
10.1128/JB.148.1.308-314.1981 / J. Bacteriol. / Dissociation and reassembly of Escherichia coli type 1 pili by Eshdat (1981)
10.1056/NEJM199709043371004 / N. Engl. J. Med. / Multidrug resistance in Yersinia pestis mediated by a transferable plasmid by Galimand (1997)
10.1002/j.1460-2075.1996.tb00753.x / EMBO J. / Molecular basis of two subfamilies of immunoglobulin-like chaperones by Hung (1996)
10.1016/S0021-9258(18)99895-9 / J. Biol. Chem. / Chaperone-assisted self-assembly of pili independent of cellular energy by Jacob-Dubuisson (1994)
10.1107/S0108767390010224 / Acta Crystallogr. / Improved methods for building protein models in electron density maps and the location of errors in these models by Jones (1991)
10.1038/35038073 / Nature / Metapopulation dynamics of bubonic plague by Keeling (2000)
10.1107/S0907444993011333 / Acta Crystallogr. D / Detection, delineation, measurement and display of cavities in macromolecular structures by Kleywegt (1994)
10.1016/S1367-5931(00)00144-7 / Curr. Opin. Chem. Biol. / Bacterial adhesins by Knight (2000)
10.1107/S0021889891004399 / J. Appl. Crystallogr. / Molscript by Kraulis (1991)
10.1016/S0076-6879(97)77016-2 / Methods Enzymol. / Automated refinement for protein crystallography by Lamzin (1997)
10.1006/jmbi.1993.1648 / J. Mol. Biol. / Shape complementarity at protein/protein interfaces by Lawrence (1993)
10.1046/j.1365-2958.2001.02199.x / Mol. Microbiol. / An extended hydrophobic interactive surface of Yersinia pestis Caf1M chaperone is essential for subunit binding and F1 capsule assembly by MacIntyre (2001)
10.1016/0022-2836(87)90038-6 / J. Mol. Biol. / Interior and surface of monomeric proteins by Miller (1987)
10.1107/S0907444996012255 / Acta Crystallogr. D / Refinement of macromolecular structures by the maximum-likelihood method by Murshudov (1997)
10.1107/S0108767393007597 / Acta Crystallogr. A / AMoRe by Navaza (1994)
{'key': '10.1016/S0092-8674(03)00351-9_BIB21', 'series-title': 'GRASP', 'author': 'Nicholls', 'year': '1993'} / GRASP by Nicholls (1993)
10.1016/S0959-440X(00)00074-9 / Curr. Opin. Struct. Biol. / Molecular chaperones by Saibil (2000)
10.1126/science.285.5430.1058 / Science / Structural basis of chaperone function and pilus biogenesis by Sauer (1999)
10.1016/S0092-8674(02)01050-4 / Cell / Chaperone priming of pilus subunits facilitates a topological transition that drives fiber formation by Sauer (2002)
10.1093/emboj/17.21.6155 / EMBO J. / Periplasmic chaperone recognition motif of subunits mediates quaternary interactions in the pilus by Soto (1998)
10.1016/S1369-5274(98)80015-5 / Curr. Opin. Microbiol. / The chaperone/usher pathway by Thanassi (1998)
10.1128/JB.184.22.6260-6269.2002 / J. Bacteriol. / Bacterial outer membrane ushers contain distinct targeting and assembly domains for pilus biogenesis by Thanassi (2002)
10.1016/S0264-410X(01)00163-3 / Vaccine / Vaccination against bubonic and pneumonic plague by Titball (2001)
10.1016/S0022-2836(02)00845-8 / J. Mol. Biol. / Chaperone-independent folding of type 1 pilus domains by Vetsch (2002)
10.1002/pro.5560070117 / Protein Sci. / The response of T4 lysozyme to large-to-small substitutions within the core and its relation to the hydrophobic effect by Xu (1998)
10.1042/bj3240571 / Biochem. J. / Influence of the conserved disulphide bond, exposed to the putative binding pocket, on the structure and function of the immunoglobulin-like molecular chaperone Caf1M of Yersinia pestis by Zav'yalov (1997)
10.1107/S0907444902021054 / Acta Crystallogr. D Biol. Crystallogr. / Overexpression, purification, crystallization and preliminary X-ray diffraction analysis of the F1 antigen Caf1M–Caf1 chaperone–subunit pre-assembly complex from Yersinia pestis by Zavialov (2003)
10.1046/j.1365-2958.2002.03066.x / Mol. Microbiol. / Donor strand complementation mechanism in the biogenesis of non-pilus systems by Zavialov (2002)

Dates

Type	When
Created	21 years, 4 months ago (April 15, 2004, 5:36 a.m.)
Deposited	4 years, 2 months ago (June 15, 2021, 12:27 p.m.)
Indexed	2 months ago (June 26, 2025, 9:29 a.m.)
Issued	22 years, 4 months ago (May 1, 2003)
Published	22 years, 4 months ago (May 1, 2003)
Published Print	22 years, 4 months ago (May 1, 2003)

Funders 0

None

BibTeX

@article{Zavialov_2003, title={Structure and Biogenesis of the Capsular F1 Antigen from Yersinia pestis}, volume={113}, ISSN={0092-8674}, url={http://dx.doi.org/10.1016/s0092-8674(03)00351-9}, DOI={10.1016/s0092-8674(03)00351-9}, number={5}, journal={Cell}, publisher={Elsevier BV}, author={Zavialov, Anton V and Berglund, Jenny and Pudney, Alexander F and Fooks, Laura J and Ibrahim, Tara M and MacIntyre, Sheila and Knight, Stefan D}, year={2003}, month=may, pages={587–596} }

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      "author": "Chapman",
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      "volume": "285",
      "author": "Choudhury",
      "year": "1999",
      "journal-title": "Science"
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      "article-title": "Role of fraction 1 antigen of Yersinia pestis in inhibition of phagocytosis",
      "volume": "70",
      "author": "Du",
      "year": "2002",
      "journal-title": "Infect. Immun."
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      "author": "Eshdat",
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      "journal-title": "J. Bacteriol."
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      "volume": "337",
      "author": "Galimand",
      "year": "1997",
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      "author": "Knight",
      "year": "2000",
      "journal-title": "Curr. Opin. Chem. Biol."
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      "article-title": "Molscript",
      "volume": "24",
      "author": "Kraulis",
      "year": "1991",
      "journal-title": "J. Appl. Crystallogr."
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    {
      "key": "10.1016/S0092-8674(03)00351-9_BIB15",
      "doi-asserted-by": "crossref",
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      "author": "Lawrence",
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      "article-title": "Interior and surface of monomeric proteins",
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      "author": "Miller",
      "year": "1987",
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      "year": "2002",
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      "volume": "322",
      "author": "Vetsch",
      "year": "2002",
      "journal-title": "J. Mol. Biol."
    },
    {
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      "first-page": "158",
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      "article-title": "The response of T4 lysozyme to large-to-small substitutions within the core and its relation to the hydrophobic effect",
      "volume": "7",
      "author": "Xu",
      "year": "1998",
      "journal-title": "Protein Sci."
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      "volume": "324",
      "author": "Zav'yalov",
      "year": "1997",
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