DOI: 10.1016/s0092-8674(03)00149-1. Structural Evidence for Feedback Activation by Ras·GTP of the Ras-Specific Nucleotide Exchange Factor SOS

Structural Evidence for Feedback Activation by Ras·GTP of the Ras-Specific Nucleotide Exchange Factor SOS

10.1016/s0092-8674(03)00149-1

Crossref journal-article

Elsevier BV

Cell (78)

Bibliography

Margarit, S. M., Sondermann, H., Hall, B. E., Nagar, B., Hoelz, A., Pirruccello, M., Bar-Sagi, D., & Kuriyan, J. (2003). Structural Evidence for Feedback Activation by RasÂ·GTP of the Ras-Specific Nucleotide Exchange Factor SOS. Cell, 112(5), 685â695.

Authors 8

S.Mariana Margarit (first)
Holger Sondermann (additional)
Brian E. Hall (additional)
Bhushan Nagar (additional)
Andre Hoelz (additional)
Michelle Pirruccello (additional)
Dafna Bar-Sagi (additional)
John Kuriyan (additional)

References 32 Referenced 392

{'key': '10.1016/S0092-8674(03)00149-1_BIB1', 'first-page': '45', 'article-title': 'Fluorescence methods in the study of small GTP-binding proteins', 'volume': '189', 'author': 'Ahmadian', 'year': '2002', 'journal-title': 'Methods Mol. Biol.'} / Methods Mol. Biol. / Fluorescence methods in the study of small GTP-binding proteins by Ahmadian (2002)
10.1016/1043-2760(94)90014-0 / Trends Endocrinol. Metab. / The SOS (son of sevenless) protein by Bar-Sagi (1994)
10.1038/366643a0 / Nature / Proteins regulating ras and its relatives by Boguski (1993)
10.1126/science.1736363 / Science / The Son of sevenless gene product by Bonfini (1992)
10.1038/28548 / Nature / The structural basis of the activation of Ras by Sos by Boriack-Sjodin (1998)
10.1016/0092-8674(87)90076-6 / Cell / The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway by Broek (1987)
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{'key': '10.1016/S0092-8674(03)00149-1_BIB10', 'first-page': '760', 'article-title': 'Collaborative Computational Project 4) The CCP4 suite', 'volume': '50', 'author': 'CCP4', 'year': '1994', 'journal-title': 'Acta Crystallogr. D'} / Acta Crystallogr. D / Collaborative Computational Project 4) The CCP4 suite by CCP4 (1994)
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10.1128/MCB.18.2.880 / Mol. Cell. Biol. / Regulation of Sos activity by intramolecular interactions by Corbalan-Garcia (1998)
10.1074/jbc.M907269199 / J. Biol. Chem. / Control of intramolecular interactions between the pleckstrin homology and Dbl homology domains of Vav and Sos1 regulates Rac binding by Das (2000)
10.1016/S0955-0674(02)00314-9 / Curr. Opin. Cell Biol. / Self-perpetuating states in signal transduction by Ferrell (2002)
10.1074/jbc.M101727200 / J. Biol. Chem. / Structure-based mutagenesis reveals distinct functions for Ras switch 1 and switch 2 in Sos-catalyzed guanine nucleotide exchange by Hall (2001)
10.1002/prot.340170108 / Proteins / Performance evaluation of amnio acid substitution matrices by Henikoff (1993)
10.1107/S0907444996001783 / Acta Crystallogr. D / Efficient rebuilding of protein structures by Kleywegt (1996)
10.1021/ja002723o / J. Am. Chem. Soc. / Synthesis of functional Ras lipoproteins and fluorescent derivatives by Kuhn (2001)
10.1128/MCB.13.3.1345 / Mol. Cell. Biol. / Influence of guanine nucleotides on complex formation between Ras and CDC25 protein by Lai (1993)
Margarit, S.M. (2002). A feedback mechanism for Ras activation: structural studies of the Ras/Sos complex. PhD thesis, State University of New York, Stony Brook, New York.
10.1126/science.2406906 / Science / Molecular switch for signal transduction by Milburn (1990)
10.1107/S0108767393007597 / Acta Crystallogr. A / AMoRe by Navazza (1994)
10.1126/science.279.5350.560 / Science / Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos by Nimnual (1998)
10.1016/S0076-6879(97)76066-X / Methods Enzymol. / Processing of X-ray diffraction data collected in oscillation mode by Otwinowski (1997)
10.1016/S0092-8674(00)00196-3 / Cell / Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma by Pacold (2000)
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10.1016/S0079-6603(02)71047-7 / Prog. Nucleic Acid Res. Mol. Biol. / A growing family of guanine nucleotide exchange factors is responsible for activation of Ras-family GTPases by Quilliam (2002)
10.1074/jbc.M005327200 / J. Biol. Chem. / Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction by Rebhun (2000)
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10.1016/S0014-5793(99)00555-4 / FEBS Lett. / Structural and biochemical analysis of Ras-effector signaling via RalGDS by Vetter (1999)
10.1080/10739149709351443 / Instrumentation Science & Technology / Multiangle light scattering by Wyatt (1997)

Dates

Type	When
Created	21 years, 4 months ago (April 15, 2004, 5:36 a.m.)
Deposited	6 years, 6 months ago (Feb. 13, 2019, 9:21 p.m.)
Indexed	17 hours, 40 minutes ago (Aug. 21, 2025, 12:55 p.m.)
Issued	22 years, 5 months ago (March 1, 2003)
Published	22 years, 5 months ago (March 1, 2003)
Published Print	22 years, 5 months ago (March 1, 2003)

Funders 0

None

BibTeX

@article{Margarit_2003, title={Structural Evidence for Feedback Activation by Ras·GTP of the Ras-Specific Nucleotide Exchange Factor SOS}, volume={112}, ISSN={0092-8674}, url={http://dx.doi.org/10.1016/s0092-8674(03)00149-1}, DOI={10.1016/s0092-8674(03)00149-1}, number={5}, journal={Cell}, publisher={Elsevier BV}, author={Margarit, S.Mariana and Sondermann, Holger and Hall, Brian E. and Nagar, Bhushan and Hoelz, Andre and Pirruccello, Michelle and Bar-Sagi, Dafna and Kuriyan, John}, year={2003}, month=mar, pages={685–695} }

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