DOI: 10.1016/s0092-8674(03)00034-5. Structural Basis for Phosphodependent Substrate Selection and Orientation by the SCFCdc4 Ubiquitin Ligase

Structural Basis for Phosphodependent Substrate Selection and Orientation by the SCFCdc4 Ubiquitin Ligase

10.1016/s0092-8674(03)00034-5

Crossref journal-article

Elsevier BV

Cell (78)

Bibliography

Orlicky, S., Tang, X., Willems, A., Tyers, M., & Sicheri, F. (2003). Structural Basis for Phosphodependent Substrate Selection and Orientation by the SCFCdc4 Ubiquitin Ligase. Cell, 112(2), 243â256.

Authors 5

Stephen Orlicky (first)
Xiaojing Tang (additional)
Andrew Willems (additional)
Mike Tyers (additional)
Frank Sicheri (additional)

References 48 Referenced 429

10.1016/S0092-8674(00)80098-7 / Cell / SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box by Bai (1996)
{'key': '10.1016/S0092-8674(03)00034-5_BIB2', 'first-page': '905', 'article-title': 'Crystallography and NMR system', 'volume': '54', 'author': 'Brunger', 'year': '1998', 'journal-title': 'Acta Crystallogr. D Biol. Crystallogr.'} / Acta Crystallogr. D Biol. Crystallogr. / Crystallography and NMR system by Brunger (1998)
10.1107/S0021889891007240 / J. Appl. Crystallgr. / Ribbons 2.0 by Carson (1991)
10.1101/gad.867501 / Genes Dev. / Negative regulation of Gcn4 and Msn2 transcription factors by Srb10 cyclin-dependent kinase by Chi (2001)
10.1016/S0968-0004(00)01712-6 / Trends Biochem. Sci. / The regulation of protein function by multisite phosphorylation by Cohen (2000)
10.1016/S0076-6879(97)76073-7 / Methods Enzymol. / Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods by de La Fortelle (1997)
10.1038/379277a0 / Nature / Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2 by Eck (1996)
10.1016/S0959-440X(99)00038-X / Curr. Opin. Struct. Biol. / Cyclin-dependent kinases by Endicott (1999)
10.1016/S0092-8674(00)80404-3 / Cell / A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p by Feldman (1997)
10.1016/S0968-0004(96)20026-X / Trends Biochem. Sci. / Tripping the switch fantastic by Ferrell (1996)
{'key': '10.1016/S0092-8674(03)00034-5_BIB11', 'first-page': '715', 'article-title': 'Beta propellers', 'volume': '9', 'author': 'Fulop', 'year': '1999', 'journal-title': 'Curr. Opin. Struct. Biol.'} / Curr. Opin. Struct. Biol. / Beta propellers by Fulop (1999)
10.1016/S0969-2126(01)00657-8 / Structure / Structure of a conjugating enzyme-ubiquitin thiolester intermediate reveals a novel role for the ubiquitin tail by Hamilton (2001)
10.1016/S0960-9822(01)00253-6 / Curr. Biol. / Protein destruction by Harper (2001)
10.1101/gad.1013102 / Genes Dev. / The anaphase-promoting complex by Harper (2002)
10.1146/annurev.biochem.67.1.425 / Annu. Rev. Biochem. / The ubiquitin system by Hershko (1998)
10.1128/MCB.21.7.2506-2520.2001 / Mol. Cell. Biol. / F-box protein Grr1 interacts with phosphorylated targets via the cationic surface of its leucine-rich repeat by Hsiung (2001)
10.1126/science.286.5443.1321 / Science / Structure of an E6AP-UbcH7 complex by Huang (1999)
10.1107/S0108767390010224 / Acta Crystallogr. A / Improved methods for binding protein models in electron density maps and the localization of errors in these models by Jones (1991)
10.1038/nrc885 / Nat. Rev. Cancer / Molecular basis of the VHL hereditary cancer syndrome by Kaelin (2002)
10.1056/NEJMoa021153 / N. Engl. J. Med. / Cyclin E and survival in patients with breast cancer by Keyomarsi (2002)
10.1126/science.1065203 / Science / Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase by Koepp (2001)
10.1016/S0960-9822(01)00679-0 / Curr. Biol. / Protein degradation by Lai (2002)
10.1016/S1097-2765(02)00513-0 / Mol. Cell / The yeast CDK inhibitor Sic1 prevents genomic instability by promoting replication origin licensing in late G1 by Lengronne (2002)
10.1002/(SICI)1521-3773(19981102)37:20<2754::AID-ANIE2754>3.0.CO;2-3 / Angew. Chem. / Polyvalent interactions in biological systems by Mammen (1998)
10.1091/mbc.11.3.915 / Mol. Biol. Cell / Degradation of the transcription factor Gcn4 requires the kinase Pho85 and the SCFCDC4 ubiquitin-ligase complex by Meimoun (2000)
10.1107/S0021889894000191 / J. Appl. Crystallgr. / SnB by Miller (1994)
10.1038/35095068 / Nature / Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines by Moberg (2001)
10.1038/35107009 / Nature / Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication by Nash (2001)
10.1002/prot.340110407 / Proteins / Protein folding and association by Nicholls (1991)
10.1016/S0076-6879(97)76066-X / Methods Enzymol. / Processing of X-ray diffraction data collected in oscillation mode by Otwinowski (1997)
10.1016/S0168-9525(98)01473-5 / Trends Genet. / Combinatorial control in ubiquitin-dependent proteolysis by Patton (1998)
10.1146/annurev.biochem.70.1.503 / Annu. Rev. Biochem. / Mechanisms underlying ubiquitination by Pickart (2001)
10.1038/35042620 / Nature / Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex by Schulman (2000)
10.1016/0092-8674(94)90193-7 / Cell / The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae by Schwob (1994)
10.1073/pnas.211352598 / Proc. Natl. Acad. Sci. USA / Presenilin, Notch, and the genesis and treatment of Alzheimer's disease by Selkoe (2001)
10.1016/S0092-8674(00)80403-1 / Cell / F box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex by Skowyra (1997)
10.1038/45836 / Nature / Deregulated cyclin E induces chromosome instability by Spruck (1999)
{'key': '10.1016/S0092-8674(03)00034-5_BIB38', 'first-page': '4535', 'article-title': 'hCDC4 gene mutations in endometrial cancer', 'volume': '62', 'author': 'Spruck', 'year': '2002', 'journal-title': 'Cancer Res.'} / Cancer Res. / hCDC4 gene mutations in endometrial cancer by Spruck (2002)
10.1038/35095076 / Nature / Human F box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line by Strohmaier (2001)
10.1073/pnas.97.3.1096 / Proc. Natl. Acad. Sci. USA / Peptide-in-groove interactions link target proteins to the beta-propeller of clathrin by ter Haar (2000)
10.1016/0092-8674(91)90202-A / Cell / Naming a targeting signal by Varshavsky (1991)
10.1038/77929 / Nat. Struct. Biol. / Structural basis for phosphoserine-proline recognition by group IV WW domains by Verdecia (2000)
10.1126/science.278.5337.455 / Science / Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase by Verma (1997)
10.1016/S0960-9822(99)80165-1 / Curr. Biol. / F box/WD-repeat proteins Pop1p and Sud1p/Pop2p form complexes that bind and direct the proteolysis of Cdc18p by Wolf (1999)
10.1016/S0955-0674(00)00189-7 / Curr. Opin. Cell Biol. / Phosphoserine/threonine-binding domains by Yaffe (2001)
10.1016/S0092-8674(00)80487-0 / Cell / The structural basis for 14-3-3:phosphopeptide binding specificity by Yaffe (1997)
10.1016/S0092-8674(00)00057-X / Cell / Structure of a c-Cbl-UbcH7 complex by Zheng (2000)
10.1038/416703a / Nature / Structure of the Cul1-Rbx1-Skp1-Fbox-Skp2 SCF ubiquitin ligase complex by Zheng (2002)

Dates

Type	When
Created	21 years, 4 months ago (April 17, 2004, 2:47 p.m.)
Deposited	2 years, 7 months ago (Jan. 25, 2023, 5:54 p.m.)
Indexed	1 month, 1 week ago (July 19, 2025, 11:42 p.m.)
Issued	22 years, 7 months ago (Jan. 1, 2003)
Published	22 years, 7 months ago (Jan. 1, 2003)
Published Print	22 years, 7 months ago (Jan. 1, 2003)

Funders 0

None

BibTeX

@article{Orlicky_2003, title={Structural Basis for Phosphodependent Substrate Selection and Orientation by the SCFCdc4 Ubiquitin Ligase}, volume={112}, ISSN={0092-8674}, url={http://dx.doi.org/10.1016/s0092-8674(03)00034-5}, DOI={10.1016/s0092-8674(03)00034-5}, number={2}, journal={Cell}, publisher={Elsevier BV}, author={Orlicky, Stephen and Tang, Xiaojing and Willems, Andrew and Tyers, Mike and Sicheri, Frank}, year={2003}, month=jan, pages={243–256} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        20
      ]
    ],
    "date-time": "2025-07-20T03:42:17Z",
    "timestamp": 1752982937468
  },
  "reference-count": 48,
  "publisher": "Elsevier BV",
  "issue": "2",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2003,
            1,
            1
          ]
        ],
        "date-time": "2003-01-01T00:00:00Z",
        "timestamp": 1041379200000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2013,
            7,
            17
          ]
        ],
        "date-time": "2013-07-17T00:00:00Z",
        "timestamp": 1374019200000
      },
      "content-version": "vor",
      "delay-in-days": 3850,
      "URL": "http://www.elsevier.com/open-access/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2003,
            1,
            1
          ]
        ],
        "date-time": "2003-01-01T00:00:00Z",
        "timestamp": 1041379200000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-017"
    },
    {
      "start": {
        "date-parts": [
          [
            2003,
            1,
            1
          ]
        ],
        "date-time": "2003-01-01T00:00:00Z",
        "timestamp": 1041379200000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-037"
    },
    {
      "start": {
        "date-parts": [
          [
            2003,
            1,
            1
          ]
        ],
        "date-time": "2003-01-01T00:00:00Z",
        "timestamp": 1041379200000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-012"
    },
    {
      "start": {
        "date-parts": [
          [
            2003,
            1,
            1
          ]
        ],
        "date-time": "2003-01-01T00:00:00Z",
        "timestamp": 1041379200000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-029"
    },
    {
      "start": {
        "date-parts": [
          [
            2003,
            1,
            1
          ]
        ],
        "date-time": "2003-01-01T00:00:00Z",
        "timestamp": 1041379200000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-004"
    }
  ],
  "content-domain": {
    "domain": [
      "cell.com",
      "elsevier.com",
      "sciencedirect.com"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        2003,
        1
      ]
    ]
  },
  "DOI": "10.1016/s0092-8674(03)00034-5",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2004,
        4,
        17
      ]
    ],
    "date-time": "2004-04-17T18:47:25Z",
    "timestamp": 1082227645000
  },
  "page": "243-256",
  "update-policy": "http://dx.doi.org/10.1016/elsevier_cm_policy",
  "source": "Crossref",
  "is-referenced-by-count": 429,
  "title": "Structural Basis for Phosphodependent Substrate Selection and Orientation by the SCFCdc4 Ubiquitin Ligase",
  "prefix": "10.1016",
  "volume": "112",
  "author": [
    {
      "given": "Stephen",
      "family": "Orlicky",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Xiaojing",
      "family": "Tang",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Andrew",
      "family": "Willems",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Mike",
      "family": "Tyers",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Frank",
      "family": "Sicheri",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB1",
      "doi-asserted-by": "crossref",
      "first-page": "263",
      "DOI": "10.1016/S0092-8674(00)80098-7",
      "article-title": "SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box",
      "volume": "86",
      "author": "Bai",
      "year": "1996",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB2",
      "first-page": "905",
      "article-title": "Crystallography and NMR system",
      "volume": "54",
      "author": "Brunger",
      "year": "1998",
      "journal-title": "Acta Crystallogr. D Biol. Crystallogr."
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "958",
      "DOI": "10.1107/S0021889891007240",
      "article-title": "Ribbons 2.0",
      "volume": "24",
      "author": "Carson",
      "year": "1991",
      "journal-title": "J. Appl. Crystallgr."
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB4",
      "doi-asserted-by": "crossref",
      "first-page": "1078",
      "DOI": "10.1101/gad.867501",
      "article-title": "Negative regulation of Gcn4 and Msn2 transcription factors by Srb10 cyclin-dependent kinase",
      "volume": "15",
      "author": "Chi",
      "year": "2001",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB5",
      "doi-asserted-by": "crossref",
      "first-page": "596",
      "DOI": "10.1016/S0968-0004(00)01712-6",
      "article-title": "The regulation of protein function by multisite phosphorylation",
      "volume": "25",
      "author": "Cohen",
      "year": "2000",
      "journal-title": "Trends Biochem. Sci."
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "472",
      "DOI": "10.1016/S0076-6879(97)76073-7",
      "article-title": "Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods",
      "volume": "276",
      "author": "de La Fortelle",
      "year": "1997",
      "journal-title": "Methods Enzymol."
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "277",
      "DOI": "10.1038/379277a0",
      "article-title": "Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2",
      "volume": "379",
      "author": "Eck",
      "year": "1996",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB8",
      "doi-asserted-by": "crossref",
      "first-page": "738",
      "DOI": "10.1016/S0959-440X(99)00038-X",
      "article-title": "Cyclin-dependent kinases",
      "volume": "9",
      "author": "Endicott",
      "year": "1999",
      "journal-title": "Curr. Opin. Struct. Biol."
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "221",
      "DOI": "10.1016/S0092-8674(00)80404-3",
      "article-title": "A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p",
      "volume": "91",
      "author": "Feldman",
      "year": "1997",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "460",
      "DOI": "10.1016/S0968-0004(96)20026-X",
      "article-title": "Tripping the switch fantastic",
      "volume": "21",
      "author": "Ferrell",
      "year": "1996",
      "journal-title": "Trends Biochem. Sci."
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB11",
      "first-page": "715",
      "article-title": "Beta propellers",
      "volume": "9",
      "author": "Fulop",
      "year": "1999",
      "journal-title": "Curr. Opin. Struct. Biol."
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "897",
      "DOI": "10.1016/S0969-2126(01)00657-8",
      "article-title": "Structure of a conjugating enzyme-ubiquitin thiolester intermediate reveals a novel role for the ubiquitin tail",
      "volume": "9",
      "author": "Hamilton",
      "year": "2001",
      "journal-title": "Structure"
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "R431",
      "DOI": "10.1016/S0960-9822(01)00253-6",
      "article-title": "Protein destruction",
      "volume": "11",
      "author": "Harper",
      "year": "2001",
      "journal-title": "Curr. Biol."
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "2179",
      "DOI": "10.1101/gad.1013102",
      "article-title": "The anaphase-promoting complex",
      "volume": "16",
      "author": "Harper",
      "year": "2002",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "425",
      "DOI": "10.1146/annurev.biochem.67.1.425",
      "article-title": "The ubiquitin system",
      "volume": "67",
      "author": "Hershko",
      "year": "1998",
      "journal-title": "Annu. Rev. Biochem."
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "2506",
      "DOI": "10.1128/MCB.21.7.2506-2520.2001",
      "article-title": "F-box protein Grr1 interacts with phosphorylated targets via the cationic surface of its leucine-rich repeat",
      "volume": "21",
      "author": "Hsiung",
      "year": "2001",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "1321",
      "DOI": "10.1126/science.286.5443.1321",
      "article-title": "Structure of an E6AP-UbcH7 complex",
      "volume": "286",
      "author": "Huang",
      "year": "1999",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "110",
      "DOI": "10.1107/S0108767390010224",
      "article-title": "Improved methods for binding protein models in electron density maps and the localization of errors in these models",
      "volume": "47",
      "author": "Jones",
      "year": "1991",
      "journal-title": "Acta Crystallogr. A"
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "673",
      "DOI": "10.1038/nrc885",
      "article-title": "Molecular basis of the VHL hereditary cancer syndrome",
      "volume": "2",
      "author": "Kaelin",
      "year": "2002",
      "journal-title": "Nat. Rev. Cancer"
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "1566",
      "DOI": "10.1056/NEJMoa021153",
      "article-title": "Cyclin E and survival in patients with breast cancer",
      "volume": "347",
      "author": "Keyomarsi",
      "year": "2002",
      "journal-title": "N. Engl. J. Med."
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB21",
      "doi-asserted-by": "crossref",
      "first-page": "173",
      "DOI": "10.1126/science.1065203",
      "article-title": "Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase",
      "volume": "294",
      "author": "Koepp",
      "year": "2001",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "R74",
      "DOI": "10.1016/S0960-9822(01)00679-0",
      "article-title": "Protein degradation",
      "volume": "12",
      "author": "Lai",
      "year": "2002",
      "journal-title": "Curr. Biol."
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "1067",
      "DOI": "10.1016/S1097-2765(02)00513-0",
      "article-title": "The yeast CDK inhibitor Sic1 prevents genomic instability by promoting replication origin licensing in late G1",
      "volume": "9",
      "author": "Lengronne",
      "year": "2002",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "2754",
      "DOI": "10.1002/(SICI)1521-3773(19981102)37:20<2754::AID-ANIE2754>3.0.CO;2-3",
      "article-title": "Polyvalent interactions in biological systems",
      "volume": "37",
      "author": "Mammen",
      "year": "1998",
      "journal-title": "Angew. Chem."
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "915",
      "DOI": "10.1091/mbc.11.3.915",
      "article-title": "Degradation of the transcription factor Gcn4 requires the kinase Pho85 and the SCFCDC4 ubiquitin-ligase complex",
      "volume": "11",
      "author": "Meimoun",
      "year": "2000",
      "journal-title": "Mol. Biol. Cell"
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB26",
      "doi-asserted-by": "crossref",
      "first-page": "613",
      "DOI": "10.1107/S0021889894000191",
      "article-title": "SnB",
      "volume": "27",
      "author": "Miller",
      "year": "1994",
      "journal-title": "J. Appl. Crystallgr."
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB27",
      "doi-asserted-by": "crossref",
      "first-page": "311",
      "DOI": "10.1038/35095068",
      "article-title": "Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines",
      "volume": "413",
      "author": "Moberg",
      "year": "2001",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "514",
      "DOI": "10.1038/35107009",
      "article-title": "Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication",
      "volume": "414",
      "author": "Nash",
      "year": "2001",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "281",
      "DOI": "10.1002/prot.340110407",
      "article-title": "Protein folding and association",
      "volume": "11",
      "author": "Nicholls",
      "year": "1991",
      "journal-title": "Proteins"
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "307",
      "DOI": "10.1016/S0076-6879(97)76066-X",
      "article-title": "Processing of X-ray diffraction data collected in oscillation mode",
      "volume": "276",
      "author": "Otwinowski",
      "year": "1997",
      "journal-title": "Methods Enzymol."
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "236",
      "DOI": "10.1016/S0168-9525(98)01473-5",
      "article-title": "Combinatorial control in ubiquitin-dependent proteolysis",
      "volume": "14",
      "author": "Patton",
      "year": "1998",
      "journal-title": "Trends Genet."
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "503",
      "DOI": "10.1146/annurev.biochem.70.1.503",
      "article-title": "Mechanisms underlying ubiquitination",
      "volume": "70",
      "author": "Pickart",
      "year": "2001",
      "journal-title": "Annu. Rev. Biochem."
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "381",
      "DOI": "10.1038/35042620",
      "article-title": "Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex",
      "volume": "408",
      "author": "Schulman",
      "year": "2000",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "233",
      "DOI": "10.1016/0092-8674(94)90193-7",
      "article-title": "The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae",
      "volume": "79",
      "author": "Schwob",
      "year": "1994",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "11039",
      "DOI": "10.1073/pnas.211352598",
      "article-title": "Presenilin, Notch, and the genesis and treatment of Alzheimer's disease",
      "volume": "98",
      "author": "Selkoe",
      "year": "2001",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB36",
      "doi-asserted-by": "crossref",
      "first-page": "209",
      "DOI": "10.1016/S0092-8674(00)80403-1",
      "article-title": "F box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex",
      "volume": "91",
      "author": "Skowyra",
      "year": "1997",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB37",
      "doi-asserted-by": "crossref",
      "first-page": "297",
      "DOI": "10.1038/45836",
      "article-title": "Deregulated cyclin E induces chromosome instability",
      "volume": "401",
      "author": "Spruck",
      "year": "1999",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB38",
      "first-page": "4535",
      "article-title": "hCDC4 gene mutations in endometrial cancer",
      "volume": "62",
      "author": "Spruck",
      "year": "2002",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB39",
      "doi-asserted-by": "crossref",
      "first-page": "316",
      "DOI": "10.1038/35095076",
      "article-title": "Human F box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line",
      "volume": "413",
      "author": "Strohmaier",
      "year": "2001",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "1096",
      "DOI": "10.1073/pnas.97.3.1096",
      "article-title": "Peptide-in-groove interactions link target proteins to the beta-propeller of clathrin",
      "volume": "97",
      "author": "ter Haar",
      "year": "2000",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB41",
      "doi-asserted-by": "crossref",
      "first-page": "13",
      "DOI": "10.1016/0092-8674(91)90202-A",
      "article-title": "Naming a targeting signal",
      "volume": "64",
      "author": "Varshavsky",
      "year": "1991",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB42",
      "doi-asserted-by": "crossref",
      "first-page": "639",
      "DOI": "10.1038/77929",
      "article-title": "Structural basis for phosphoserine-proline recognition by group IV WW domains",
      "volume": "7",
      "author": "Verdecia",
      "year": "2000",
      "journal-title": "Nat. Struct. Biol."
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB43",
      "doi-asserted-by": "crossref",
      "first-page": "455",
      "DOI": "10.1126/science.278.5337.455",
      "article-title": "Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase",
      "volume": "278",
      "author": "Verma",
      "year": "1997",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB44",
      "doi-asserted-by": "crossref",
      "first-page": "373",
      "DOI": "10.1016/S0960-9822(99)80165-1",
      "article-title": "F box/WD-repeat proteins Pop1p and Sud1p/Pop2p form complexes that bind and direct the proteolysis of Cdc18p",
      "volume": "9",
      "author": "Wolf",
      "year": "1999",
      "journal-title": "Curr. Biol."
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB45",
      "doi-asserted-by": "crossref",
      "first-page": "131",
      "DOI": "10.1016/S0955-0674(00)00189-7",
      "article-title": "Phosphoserine/threonine-binding domains",
      "volume": "13",
      "author": "Yaffe",
      "year": "2001",
      "journal-title": "Curr. Opin. Cell Biol."
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB46",
      "doi-asserted-by": "crossref",
      "first-page": "961",
      "DOI": "10.1016/S0092-8674(00)80487-0",
      "article-title": "The structural basis for 14-3-3:phosphopeptide binding specificity",
      "volume": "91",
      "author": "Yaffe",
      "year": "1997",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB47",
      "doi-asserted-by": "crossref",
      "first-page": "533",
      "DOI": "10.1016/S0092-8674(00)00057-X",
      "article-title": "Structure of a c-Cbl-UbcH7 complex",
      "volume": "102",
      "author": "Zheng",
      "year": "2000",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(03)00034-5_BIB48",
      "doi-asserted-by": "crossref",
      "first-page": "703",
      "DOI": "10.1038/416703a",
      "article-title": "Structure of the Cul1-Rbx1-Skp1-Fbox-Skp2 SCF ubiquitin ligase complex",
      "volume": "416",
      "author": "Zheng",
      "year": "2002",
      "journal-title": "Nature"
    }
  ],
  "container-title": "Cell",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0092867403000345?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0092867403000345?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        1,
        25
      ]
    ],
    "date-time": "2023-01-25T22:54:33Z",
    "timestamp": 1674687273000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0092867403000345"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2003,
        1
      ]
    ]
  },
  "references-count": 48,
  "journal-issue": {
    "issue": "2",
    "published-print": {
      "date-parts": [
        [
          2003,
          1
        ]
      ]
    }
  },
  "alternative-id": [
    "S0092867403000345"
  ],
  "URL": "http://dx.doi.org/10.1016/S0092-8674(03)00034-5",
  "relation": {
    "has-review": [
      {
        "id-type": "doi",
        "id": "10.3410/f.1011776.182468",
        "asserted-by": "object"
      },
      {
        "id-type": "doi",
        "id": "10.3410/f.1011776.184268",
        "asserted-by": "object"
      },
      {
        "id-type": "doi",
        "id": "10.3410/f.1011776.183477",
        "asserted-by": "object"
      }
    ]
  },
  "ISSN": [
    "0092-8674"
  ],
  "subject": [],
  "container-title-short": "Cell",
  "published": {
    "date-parts": [
      [
        2003,
        1
      ]
    ]
  },
  "assertion": [
    {
      "value": "Elsevier",
      "name": "publisher",
      "label": "This article is maintained by"
    },
    {
      "value": "Structural Basis for Phosphodependent Substrate Selection and Orientation by the SCFCdc4 Ubiquitin Ligase",
      "name": "articletitle",
      "label": "Article Title"
    },
    {
      "value": "Cell",
      "name": "journaltitle",
      "label": "Journal Title"
    },
    {
      "value": "https://doi.org/10.1016/S0092-8674(03)00034-5",
      "name": "articlelink",
      "label": "CrossRef DOI link to publisher maintained version"
    },
    {
      "value": "converted-article",
      "name": "content_type",
      "label": "Content Type"
    },
    {
      "value": "Copyright \u00a9 2003 Cell Press. Published by Elsevier Inc. All rights reserved.",
      "name": "copyright",
      "label": "Copyright"
    }
  ]
}