10.1016/s0092-8674(02)00699-2
Crossref journal-article
Elsevier BV
Cell (78)
Bibliography

Crabtree, G. R., & Olson, E. N. (2002). NFAT Signaling. Cell, 109(2), S67–S79.

Authors 2
  1. Gerald R Crabtree (first)
  2. Eric N Olson (additional)
References 98 Referenced 1,098
  1. 10.1091/mbc.9.10.2905 / Mol. Biol. Cell / Activation and cellular localization of the cyclosporine A-sensitive transcription factor NF-AT in skeletal muscle cells by Abbott (1998)
  2. 10.1073/pnas.231619298 / Proc. Natl. Acad. Sci. USA / Activated glycogen synthase kinase-3 beta suppresses cardiac hypertrophy in vivo by Antos (2002)
  3. 10.1126/science.285.5436.2129 / Science / Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A by Aramburu (1999)
  4. 10.1097/00007890-199505270-00007 / Transplantation / Calcineurin activity is only partially inhibited in leukocytes of cyclosporine-treated patients by Batiuk (1995)
  5. 10.1101/gad.11.7.824 / Genes Dev. / Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin- sensitive Intramolecular interaction by Beals (1997)
  6. 10.1126/science.275.5308.1930 / Science / Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3 by Beals (1997)
  7. 10.1038/27094 / Nature / Calcium—a life and death signal by Berridge (1998)
  8. 10.1074/jbc.275.1.197 / J. Biol. Chem. / Ca(2+)-dependent gene expression mediated by MEF2 transcription factors by Blaeser (2000)
  9. 10.1128/MCB.19.1.515 / Mol. Cell. Biol. / Fiber-type-specific transcription of the troponin I slow gene is regulated by multiple elements by Calvo (1999)
  10. 10.1038/32100 / Nature / Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA by Chen (1998)
  11. 10.1101/gad.12.16.2499 / Genes Dev. / A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type by Chin (1998)
  12. 10.1016/1074-7613(94)90096-5 / Immunity / Induction of NF-AT in normal B lymphocytes by anti-immunoglobulin or CD40 ligand in conjunction with IL-4 by Choi (1994)
  13. 10.1038/357695a0 / Nature / Identification of calcineurin as a key signalling enzyme in T cell activation by Clipstone (1992)
  14. 10.1126/science.2783497 / Science / Contingent genetic regulatory events in T lymphocyte activation by Crabtree (1989)
  15. 10.1038/32419 / Nature / Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum by de la Pompa (1998)
  16. 10.1046/j.1540-8167.2001.01055.x / J. Cardiovasc. Electrophysiol. / Calcineurin inhibition ameliorates structural, contractile, and electrophysiologic consequences of postinfarction remodeling by Deng (2001)
  17. 10.1073/pnas.031371998 / Proc. Natl. Acad. Sci. USA / Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo by De Windt (2002)
  18. {'key': '10.1016/S0092-8674(02)00699-2_BIB18', 'article-title': 'Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation', 'volume': 'in press', 'author': 'Diehn', 'year': '2002', 'journal-title': 'Proc. Natl. Acad. Sci. USA'} / Proc. Natl. Acad. Sci. USA / Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation by Diehn (2002)
  19. 10.1074/jbc.274.31.21908 / J. Biol. Chem. / Calcineurin is required for skeletal muscle hypertrophy by Dunn (1999)
  20. 10.1126/science.2595372 / Science / Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation by Emmel (1989)
  21. 10.1084/jem.194.10.1449 / J. Exp. Med. / Deletion of calcineurin and myocyte enhancer factor 2 (MEF2) binding domain of Cabin1 results in enhanced cytokine gene expression in T cells by Esau (2001)
  22. 10.1172/JCI11093 / J. Clin. Invest. / An abnormal Ca(2+) response in mutant sarcomere protein-mediated familial hypertrophic cardiomyopathy by Fatkin (2000)
  23. 10.1038/86318 / Nat. Immunol. / Gene regulation mediated by calcium signals in T lymphocytes by Feske (2001)
  24. 10.1038/352803a0 / Nature / Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A by Flanagan (1991)
  25. 10.1038/81321 / Nat. Med. / Decoding calcium signals involved in cardiac growth and function by Frey (2000)
  26. 10.1073/pnas.260501097 / Proc. Natl. Acad. Sci. USA / Calsarcins, a novel family of sarcomeric calcineurin-binding proteins by Frey (2000)
  27. 10.1093/hmg/4.10.1935 / Hum. Mol. Genet. / A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart by Fuentes (1995)
  28. 10.1073/pnas.96.10.5797 / Proc. Natl. Acad. Sci. USA / Calcineurin controls inositol 1,4,5-trisphosphate type 1 receptor expression in neurons by Genazzani (1999)
  29. 10.1038/44378 / Nature / L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons by Graef (1999)
  30. 10.1016/S0092-8674(01)00396-8 / Cell / Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature by Graef (2001)
  31. 10.1073/pnas.101602398 / Proc. Natl. Acad. Sci. USA / Evolutionary relationships among Rel domains indicate functional diversification by recombination by Graef (2001)
  32. 10.1016/0092-8674(95)90439-5 / Cell / X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12–FK506 complex by Griffith (1995)
  33. 10.1074/jbc.272.3.1665 / J. Biol. Chem. / Intronic enhancer activity of the eosinophil-derived neurotoxin (RNS2) and eosinophil cationic protein (RNS3) genes is mediated by an NFAT-1 consensus binding sequence by Handen (1997)
  34. 10.1083/jcb.151.1.117 / J. Cell Biol. / Glycogen synthase kinase-3beta is a negative regulator of cardiomyocyte hypertrophy by Haq (2000)
  35. 10.1084/jem.193.5.607 / J. Exp. Med. / Selective inhibition of vascular endothelial growth factor-mediated angiogenesis by cyclosporin A. Roles of the nuclear factor of activated T cells and cyclooxygenase 2 by Hernandez (2001)
  36. 10.1074/jbc.270.34.19898 / J. Biol. Chem. / NFATc3, a lymphoid-specific NFATc family member that is calcium- regulated and exhibits distinct DNA binding specificity by Ho (1995)
  37. 10.1038/35017574 / Nature / Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation by Hoeflich (2000)
  38. 10.1006/dbio.2001.0179 / Dev. Biol. / Altered primary myogenesis in NFATC3(−/−) mice leads to decreased muscle size in the adult by Kegley (2001)
  39. 10.1016/S0962-8924(00)01866-3 / Trends Cell Biol. / Human diseases by Kelsell (2001)
  40. 10.1016/S1074-7613(00)80326-X / Immunity / The T cell activation factor NF-ATc positively regulates HIV-1 replication and gene expression in T cells by Kinoshita (1997)
  41. 10.1016/S0092-8674(00)81630-X / Cell / Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells by Kinoshita (1998)
  42. 10.1038/378641a0 / Nature / Crystal structures of human calcineurin and the human FKBP12–FK506-calcineurin complex by Kissinger (1995)
  43. 10.1126/science.271.5255.1589 / Science / Coordination of three signaling enzymes by AKAP79, a mammalian scaffold protein by Klauck (1996)
  44. 10.1074/jbc.273.22.13367 / J. Biol. Chem. / Regulation of the calmodulin-stimulated protein phosphatase, calcineurin by Klee (1998)
  45. 10.1016/S0960-9822(06)00290-9 / Curr. Biol. / Rapid targeting of nuclear proteins to the cytoplasm by Klemm (1997)
  46. 10.1242/dev.127.16.3501 / Development / Loss of connexin45 causes a cushion defect in early cardiogenesis by Kumai (2000)
  47. 10.1074/jbc.273.29.18325 / J. Biol. Chem. / Cain, a novel physiologic protein inhibitor of calcineurin by Lai (1998)
  48. 10.1182/blood.V85.4.1053.bloodjournal8541053 / Blood / A primary T-cell immunodeficiency associated with defective transmembrane calcium influx by Le Deist (1995)
  49. 10.1073/pnas.051033698 / Proc. Natl. Acad. Sci. USA / Calcineurin inhibition and cardiac hypertrophy by Leinwand (2001)
  50. 10.1074/jbc.274.51.36125 / J. Biol. Chem. / Inhibition of calcineurin phosphatase activity by a calcineurin B homologous protein by Lin (1999)
  51. 10.1016/0092-8674(91)90124-H / Cell / Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes by Liu (1991)
  52. 10.1093/emboj/16.1.143 / EMBO J. / Cyclosporin A-sensitive induction of the Epstein-Barr virus lytic switch is mediated via a novel pathway involving a MEF2 family member by Liu (1997)
  53. 10.1126/science.281.5376.562 / Science / A viral mechanism for inhibition of the cellular phosphatase calcineurin by Miskin (1998)
  54. 10.1016/S0092-8674(00)81573-1 / Cell / A calcineurin-dependent transcriptional pathway for cardiac hypertrophy by Molkentin (1998)
  55. 10.1038/23060 / Nature / IGF-1 induces skeletal myocyte hypertrophy through calcineurin in association with GATA-2 and NF-ATc1 by Musaro (1999)
  56. 10.1074/jbc.275.7.4545 / J. Biol. Chem. / Stimulation of slow skeletal muscle fiber gene expression by calcineurin in vivo by Naya (2000)
  57. 10.1074/jbc.M004888200 / J. Biol. Chem. / Glycogen synthase kinase-3 inhibits the DNA binding activity of NFATc by Neal (2001)
  58. 10.1038/369497a0 / Nature / NF-AT components define a family of transcription factors targeted in T-cell activation by Northrop (1994)
  59. 10.1084/jem.192.1.99 / J. Exp. Med. / Negative regulation of T cell proliferation and interleukin 2 production by the serine threonine kinase GSK-3 by Ohteki (2000)
  60. 10.1016/S0092-8674(00)80880-6 / Cell / Calcineurin signaling and muscle remodeling by Olson (2000)
  61. 10.1016/S1074-7613(00)80612-3 / Immunity / The transcription factor NFAT4 is involved in the generation and survival of T cells by Oukka (1998)
  62. 10.1073/pnas.97.13.7130 / Proc. Natl. Acad. Sci. USA / A second calcineurin binding site on the NFAT regulatory domain by Park (2000)
  63. 10.1016/S1074-7613(01)00085-1 / Immunity / NFATc1 and NFATc2 together control both T and B cell activation and differentiation by Peng (2001)
  64. 10.1016/0092-8674(93)80061-I / Cell / The signal for capacitative calcium entry by Putney (1993)
  65. 10.1084/jem.191.1.9 / J. Exp. Med. / The nuclear factor of activated T cells (NFAT) transcription factor NFATp (NFATc2) is a repressor of chondrogenesis by Ranger (2000)
  66. 10.1038/32426 / Nature / The transcription factor NF-ATc is essential for cardiac valve formation by Ranger (1998)
  67. 10.1016/S1074-7613(00)80465-3 / Immunity / Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc by Ranger (1998)
  68. 10.1016/S1074-7613(00)80660-3 / Immunity / Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development by Ranger (1998)
  69. 10.1074/jbc.275.12.8719 / J. Biol. Chem. / A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling by Rothermel (2000)
  70. 10.1073/pnas.041614798 / Proc. Natl. Acad. Sci. USA / Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo by Rothermel (2001)
  71. 10.1161/01.CIR.102.18.2269 / Circulation / Calcineurin inhibitor attenuates left ventricular hypertrophy, leading to prevention of heart failure in hypertensive rats by Sakata (2000)
  72. 10.1038/23054 / Nature / Skeletal muscle hypertrophy is mediated by a Ca2+-dependent calcineurin signalling pathway by Semsarian (1999)
  73. 10.1016/1074-7613(95)90093-4 / Immunity / Isolation of mutant T lymphocytes with defects in capacitative calcium entry by Serafini (1995)
  74. 10.1073/pnas.231148598 / Proc. Natl. Acad. Sci. USA / Calcineurin controls nerve activity-dependent specification of slow skeletal muscle fibers but not muscle growth by Serrano (2001)
  75. 10.1126/science.3260404 / Science / Identification of a putative regulator of early T cell activation genes by Shaw (1988)
  76. 10.1161/01.CIR.100.24.2449 / Circulation / Calcineurin plays a critical role in pressure overload-induced cardiac hypertrophy by Shimoyama (1999)
  77. 10.1161/01.CIR.102.16.1996 / Circulation / Calcineurin inhibitor attenuates the development and induces the regression of cardiac hypertrophy in rats with salt-sensitive hypertension by Shimoyama (2000)
  78. 10.1128/MCB.6.9.3042 / Mol. Cell. Biol. / Promoter region of the IL-2 gene undergoes chromatin structure changes and confers inducibility on chloramphenicol acetyltransferase gene during activation of T cells by Siebenlist (1986)
  79. 10.1016/S1074-7613(00)80575-0 / Immunity / Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes by Sun (1998)
  80. 10.1126/science.281.5383.1690 / Science / Prevention of cardiac hypertrophy in mice by calcineurin inhibition by Sussman (1998)
  81. 10.1038/383837a0 / Nature / Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression by Timmerman (1996)
  82. 10.1016/S0021-9258(18)55467-3 / J. Biol. Chem. / Cell type specificity and activation requirements for NFAT-1 (nuclear factor of activated T-cells) transcriptional activity determined by a new method using transgenic mice to assay transcriptional activity of an individual nuclear factor by Verweij (1990)
  83. 10.1034/j.1600-065X.2001.790104.x / Immunol. Rev. / Regulation of IL-4 production in mast cells by Weiss (2001)
  84. 10.1038/385172a0 / Nature / Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc by Wolfe (1997)
  85. 10.1084/jem.178.5.1517 / J. Exp. Med. / p21ras and calcineurin synergize to regulate the nuclear factor of activated T cells by Woodrow (1993)
  86. 10.1093/emboj/19.9.1963 / EMBO J. / MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type by Wu (2000)
  87. 10.1093/emboj/20.22.6414 / EMBO J. / Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway by Wu (2001)
  88. 10.1126/science.272.5263.892 / Science / An enhanced immune response in mice lacking the transcription factor NFAT1 by Xanthoudakis (1996)
  89. 10.1038/35025215 / Nature / Vascular-specific growth factors and blood vessel formation by Yancopoulos (2000)
  90. 10.1161/01.RES.87.12.e61 / Circ. Res. / Independent signals control expression of the calcineurin inhibitory proteins MCIP1 and MCIP2 in striated muscles by Yang (2000)
  91. 10.1016/S1074-7613(00)80464-1 / Immunity / The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production by Yoshida (1998)
  92. 10.1038/35070596 / Nature / CaT1 manifests the pore properties of the calcium-release-activated calcium channel by Yue (2001)
  93. 10.1084/jem.183.2.413 / J. Exp. Med. / T cell responses in calcineurin A alpha-deficient mice by Zhang (1996)
  94. 10.1016/S0092-8674(00)81136-8 / Cell / Solution structure of the core NFATC1/DNA complex by Zhou (1998)
  95. {'key': '10.1016/S0092-8674(02)00699-2_BIB95', 'article-title': 'Regulation of the murine NFATc1 gene by NFATc2', 'volume': 'in press', 'author': 'Zhou', 'year': '2002', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. / Regulation of the murine NFATc1 gene by NFATc2 by Zhou (2002)
  96. 10.1038/18473 / Nature / NF-AT activation requires suppression of Crm1-dependent export by calcineurin by Zhu (1999)
  97. 10.1016/S0092-8674(00)81445-2 / Cell / Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1 by Zhu (1998)
  98. 10.1161/01.CIR.104.1.97 / Circulation / Calcineurin plays a critical role in the development of pressure overload-induced cardiac hypertrophy by Zou (2001)
Dates
Type When
Created 21 years, 4 months ago (April 15, 2004, 5:36 a.m.)
Deposited 4 years, 2 months ago (June 15, 2021, 12:29 p.m.)
Indexed 2 weeks ago (Aug. 19, 2025, 6:19 a.m.)
Issued 23 years, 5 months ago (April 1, 2002)
Published 23 years, 5 months ago (April 1, 2002)
Published Print 23 years, 5 months ago (April 1, 2002)
Funders 0

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@article{Crabtree_2002, title={NFAT Signaling}, volume={109}, ISSN={0092-8674}, url={http://dx.doi.org/10.1016/s0092-8674(02)00699-2}, DOI={10.1016/s0092-8674(02)00699-2}, number={2}, journal={Cell}, publisher={Elsevier BV}, author={Crabtree, Gerald R and Olson, Eric N}, year={2002}, month=apr, pages={S67–S79} }